-- dump date 20140620_005205 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1114970000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1114970000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970000003 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1114970000004 Walker A motif; other site 1114970000005 ATP binding site [chemical binding]; other site 1114970000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1114970000007 Walker B motif; other site 1114970000008 arginine finger; other site 1114970000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1114970000010 DnaA box-binding interface [nucleotide binding]; other site 1114970000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 1114970000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1114970000013 putative DNA binding surface [nucleotide binding]; other site 1114970000014 dimer interface [polypeptide binding]; other site 1114970000015 beta-clamp/clamp loader binding surface; other site 1114970000016 beta-clamp/translesion DNA polymerase binding surface; other site 1114970000017 recombination protein F; Reviewed; Region: recF; PRK00064 1114970000018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114970000019 Walker A/P-loop; other site 1114970000020 ATP binding site [chemical binding]; other site 1114970000021 Q-loop/lid; other site 1114970000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114970000023 ABC transporter signature motif; other site 1114970000024 Walker B; other site 1114970000025 D-loop; other site 1114970000026 H-loop/switch region; other site 1114970000027 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1114970000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970000029 Mg2+ binding site [ion binding]; other site 1114970000030 G-X-G motif; other site 1114970000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1114970000032 anchoring element; other site 1114970000033 dimer interface [polypeptide binding]; other site 1114970000034 ATP binding site [chemical binding]; other site 1114970000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1114970000036 active site 1114970000037 putative metal-binding site [ion binding]; other site 1114970000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1114970000039 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1114970000040 Spore germination protein; Region: Spore_permease; cl17796 1114970000041 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114970000042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970000043 active site 1114970000044 phosphorylation site [posttranslational modification] 1114970000045 intermolecular recognition site; other site 1114970000046 dimerization interface [polypeptide binding]; other site 1114970000047 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970000048 DNA binding site [nucleotide binding] 1114970000049 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1114970000050 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970000051 dimer interface [polypeptide binding]; other site 1114970000052 phosphorylation site [posttranslational modification] 1114970000053 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970000054 ATP binding site [chemical binding]; other site 1114970000055 Mg2+ binding site [ion binding]; other site 1114970000056 G-X-G motif; other site 1114970000057 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1114970000058 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1114970000059 putative acyl-acceptor binding pocket; other site 1114970000060 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 1114970000061 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114970000062 active site 1114970000063 motif I; other site 1114970000064 motif II; other site 1114970000065 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1114970000066 HD domain; Region: HD; pfam01966 1114970000067 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1114970000068 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1114970000069 dimer interface [polypeptide binding]; other site 1114970000070 motif 1; other site 1114970000071 active site 1114970000072 motif 2; other site 1114970000073 motif 3; other site 1114970000074 DNA-3-methyladenine glycosylase I; Region: tag; TIGR00624 1114970000075 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1114970000076 putative acyl-acceptor binding pocket; other site 1114970000077 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1114970000078 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1114970000079 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1114970000080 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114970000081 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1114970000082 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1114970000083 classical (c) SDRs; Region: SDR_c; cd05233 1114970000084 NAD(P) binding site [chemical binding]; other site 1114970000085 active site 1114970000086 NIPSNAP; Region: NIPSNAP; pfam07978 1114970000087 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114970000088 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970000089 metal binding site [ion binding]; metal-binding site 1114970000090 active site 1114970000091 I-site; other site 1114970000092 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970000093 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114970000094 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1114970000095 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 1114970000096 putative C-terminal domain interface [polypeptide binding]; other site 1114970000097 putative GSH binding site (G-site) [chemical binding]; other site 1114970000098 putative dimer interface [polypeptide binding]; other site 1114970000099 C-terminal, alpha helical domain of GTT2-like Glutathione S-transferases; Region: GST_C_GTT2_like; cd03182 1114970000100 putative N-terminal domain interface [polypeptide binding]; other site 1114970000101 putative dimer interface [polypeptide binding]; other site 1114970000102 putative substrate binding pocket (H-site) [chemical binding]; other site 1114970000103 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 1114970000104 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1114970000105 Transposase; Region: HTH_Tnp_1; pfam01527 1114970000106 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1114970000107 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1114970000108 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1114970000109 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1114970000110 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1114970000111 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1114970000112 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1114970000113 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1114970000114 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1114970000115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970000116 dimer interface [polypeptide binding]; other site 1114970000117 conserved gate region; other site 1114970000118 ABC-ATPase subunit interface; other site 1114970000119 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1114970000120 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1114970000121 Walker A/P-loop; other site 1114970000122 ATP binding site [chemical binding]; other site 1114970000123 Q-loop/lid; other site 1114970000124 ABC transporter signature motif; other site 1114970000125 Walker B; other site 1114970000126 D-loop; other site 1114970000127 H-loop/switch region; other site 1114970000128 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1114970000129 hydroperoxidase II; Provisional; Region: katE; PRK11249 1114970000130 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1114970000131 tetramer interface [polypeptide binding]; other site 1114970000132 heme binding pocket [chemical binding]; other site 1114970000133 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1114970000134 domain interactions; other site 1114970000135 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 1114970000136 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1114970000137 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1114970000138 ABC-ATPase subunit interface; other site 1114970000139 dimer interface [polypeptide binding]; other site 1114970000140 putative PBP binding regions; other site 1114970000141 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 1114970000142 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1114970000143 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1114970000144 metal binding site 2 [ion binding]; metal-binding site 1114970000145 putative DNA binding helix; other site 1114970000146 metal binding site 1 [ion binding]; metal-binding site 1114970000147 dimer interface [polypeptide binding]; other site 1114970000148 structural Zn2+ binding site [ion binding]; other site 1114970000149 ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531 1114970000150 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1114970000151 metal binding site [ion binding]; metal-binding site 1114970000152 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1114970000153 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 1114970000154 putative active site [active] 1114970000155 putative substrate binding site [chemical binding]; other site 1114970000156 ATP binding site [chemical binding]; other site 1114970000157 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 1114970000158 DNA polymerase I; Provisional; Region: PRK05755 1114970000159 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1114970000160 active site 1114970000161 metal binding site 1 [ion binding]; metal-binding site 1114970000162 putative 5' ssDNA interaction site; other site 1114970000163 metal binding site 3; metal-binding site 1114970000164 metal binding site 2 [ion binding]; metal-binding site 1114970000165 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1114970000166 putative DNA binding site [nucleotide binding]; other site 1114970000167 putative metal binding site [ion binding]; other site 1114970000168 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1114970000169 active site 1114970000170 catalytic site [active] 1114970000171 substrate binding site [chemical binding]; other site 1114970000172 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1114970000173 active site 1114970000174 DNA binding site [nucleotide binding] 1114970000175 catalytic site [active] 1114970000176 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1114970000177 G1 box; other site 1114970000178 GTP/Mg2+ binding site [chemical binding]; other site 1114970000179 Switch I region; other site 1114970000180 G2 box; other site 1114970000181 G3 box; other site 1114970000182 Switch II region; other site 1114970000183 G4 box; other site 1114970000184 G5 box; other site 1114970000185 Cytochrome c; Region: Cytochrom_C; cl11414 1114970000186 Cytochrome c553 [Energy production and conversion]; Region: COG2863 1114970000187 Cytochrome c; Region: Cytochrom_C; cl11414 1114970000188 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1114970000189 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1114970000190 catalytic residues [active] 1114970000191 hinge region; other site 1114970000192 alpha helical domain; other site 1114970000193 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1114970000194 putative catalytic site [active] 1114970000195 putative metal binding site [ion binding]; other site 1114970000196 putative phosphate binding site [ion binding]; other site 1114970000197 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114970000198 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970000199 metal binding site [ion binding]; metal-binding site 1114970000200 active site 1114970000201 I-site; other site 1114970000202 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1114970000203 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1114970000204 amidase catalytic site [active] 1114970000205 Zn binding residues [ion binding]; other site 1114970000206 substrate binding site [chemical binding]; other site 1114970000207 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1114970000208 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1114970000209 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1114970000210 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970000211 HAMP domain; Region: HAMP; pfam00672 1114970000212 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1114970000213 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970000214 putative active site [active] 1114970000215 heme pocket [chemical binding]; other site 1114970000216 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970000217 dimer interface [polypeptide binding]; other site 1114970000218 phosphorylation site [posttranslational modification] 1114970000219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970000220 ATP binding site [chemical binding]; other site 1114970000221 Mg2+ binding site [ion binding]; other site 1114970000222 G-X-G motif; other site 1114970000223 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1114970000224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970000225 active site 1114970000226 phosphorylation site [posttranslational modification] 1114970000227 intermolecular recognition site; other site 1114970000228 dimerization interface [polypeptide binding]; other site 1114970000229 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970000230 Walker A motif; other site 1114970000231 ATP binding site [chemical binding]; other site 1114970000232 Walker B motif; other site 1114970000233 arginine finger; other site 1114970000234 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1114970000235 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816 1114970000236 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 1114970000237 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1114970000238 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 1114970000239 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 1114970000240 Protein of unknown function (DUF330); Region: DUF330; cl01135 1114970000241 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1114970000242 mce related protein; Region: MCE; pfam02470 1114970000243 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1114970000244 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114970000245 Walker A/P-loop; other site 1114970000246 ATP binding site [chemical binding]; other site 1114970000247 Q-loop/lid; other site 1114970000248 ABC transporter signature motif; other site 1114970000249 Walker B; other site 1114970000250 D-loop; other site 1114970000251 H-loop/switch region; other site 1114970000252 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1114970000253 Permease; Region: Permease; pfam02405 1114970000254 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 1114970000255 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1114970000256 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1114970000257 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1114970000258 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1114970000259 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1114970000260 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1114970000261 PhoU domain; Region: PhoU; pfam01895 1114970000262 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1114970000263 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1114970000264 Citrate transporter; Region: CitMHS; pfam03600 1114970000265 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883 1114970000266 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970000267 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1114970000268 NAD(P) binding site [chemical binding]; other site 1114970000269 active site 1114970000270 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 1114970000271 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970000272 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1114970000273 dimerization interface [polypeptide binding]; other site 1114970000274 substrate binding pocket [chemical binding]; other site 1114970000275 Sulfatase; Region: Sulfatase; cl17466 1114970000276 choline-sulfatase; Region: chol_sulfatase; TIGR03417 1114970000277 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 1114970000278 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1114970000279 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 1114970000280 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1114970000281 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1114970000282 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1114970000283 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1114970000284 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1114970000285 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1114970000286 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1114970000287 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1114970000288 shikimate binding site; other site 1114970000289 NAD(P) binding site [chemical binding]; other site 1114970000290 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1114970000291 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1114970000292 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1114970000293 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1114970000294 NADP binding site [chemical binding]; other site 1114970000295 dimer interface [polypeptide binding]; other site 1114970000296 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1114970000297 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1114970000298 DNA protecting protein DprA; Region: dprA; TIGR00732 1114970000299 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114970000300 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1114970000301 active site 1114970000302 catalytic residues [active] 1114970000303 metal binding site [ion binding]; metal-binding site 1114970000304 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1114970000305 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1114970000306 putative active site [active] 1114970000307 substrate binding site [chemical binding]; other site 1114970000308 putative cosubstrate binding site; other site 1114970000309 catalytic site [active] 1114970000310 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1114970000311 substrate binding site [chemical binding]; other site 1114970000312 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1114970000313 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1114970000314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970000315 S-adenosylmethionine binding site [chemical binding]; other site 1114970000316 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1114970000317 TrkA-N domain; Region: TrkA_N; pfam02254 1114970000318 TrkA-C domain; Region: TrkA_C; pfam02080 1114970000319 TrkA-N domain; Region: TrkA_N; pfam02254 1114970000320 TrkA-C domain; Region: TrkA_C; pfam02080 1114970000321 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114970000322 TPR motif; other site 1114970000323 TPR repeat; Region: TPR_11; pfam13414 1114970000324 binding surface 1114970000325 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1114970000326 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1114970000327 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1114970000328 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1114970000329 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1114970000330 Protein of unknown function (DUF2459); Region: DUF2459; pfam09601 1114970000331 Restriction endonuclease; Region: Mrr_cat; pfam04471 1114970000332 Protein of unknown function (DUF867); Region: DUF867; pfam05908 1114970000333 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1114970000334 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1114970000335 Cu(I) binding site [ion binding]; other site 1114970000336 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1114970000337 UbiA prenyltransferase family; Region: UbiA; pfam01040 1114970000338 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1114970000339 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1114970000340 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1114970000341 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 1114970000342 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 1114970000343 Subunit III/VIIa interface [polypeptide binding]; other site 1114970000344 Phospholipid binding site [chemical binding]; other site 1114970000345 Subunit I/III interface [polypeptide binding]; other site 1114970000346 Subunit III/VIb interface [polypeptide binding]; other site 1114970000347 Subunit III/VIa interface; other site 1114970000348 Subunit III/Vb interface [polypeptide binding]; other site 1114970000349 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 1114970000350 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1114970000351 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 1114970000352 Subunit I/III interface [polypeptide binding]; other site 1114970000353 D-pathway; other site 1114970000354 Subunit I/VIIc interface [polypeptide binding]; other site 1114970000355 Subunit I/IV interface [polypeptide binding]; other site 1114970000356 Subunit I/II interface [polypeptide binding]; other site 1114970000357 Low-spin heme (heme a) binding site [chemical binding]; other site 1114970000358 Subunit I/VIIa interface [polypeptide binding]; other site 1114970000359 Subunit I/VIa interface [polypeptide binding]; other site 1114970000360 Dimer interface; other site 1114970000361 Putative water exit pathway; other site 1114970000362 Binuclear center (heme a3/CuB) [ion binding]; other site 1114970000363 K-pathway; other site 1114970000364 Subunit I/Vb interface [polypeptide binding]; other site 1114970000365 Putative proton exit pathway; other site 1114970000366 Subunit I/VIb interface; other site 1114970000367 Subunit I/VIc interface [polypeptide binding]; other site 1114970000368 Electron transfer pathway; other site 1114970000369 Subunit I/VIIIb interface [polypeptide binding]; other site 1114970000370 Subunit I/VIIb interface [polypeptide binding]; other site 1114970000371 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1114970000372 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 1114970000373 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1114970000374 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1114970000375 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1114970000376 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1114970000377 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1114970000378 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1114970000379 active site clefts [active] 1114970000380 zinc binding site [ion binding]; other site 1114970000381 dimer interface [polypeptide binding]; other site 1114970000382 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1114970000383 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114970000384 FeS/SAM binding site; other site 1114970000385 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1114970000386 active site 1114970000387 catalytic residues [active] 1114970000388 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1114970000389 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1114970000390 Zn binding site [ion binding]; other site 1114970000391 Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526 1114970000392 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1114970000393 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1114970000394 active site 1114970000395 Zn binding site [ion binding]; other site 1114970000396 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1114970000397 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1114970000398 trimer interface [polypeptide binding]; other site 1114970000399 putative metal binding site [ion binding]; other site 1114970000400 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1114970000401 Eukaryotic phosphomannomutase; Region: PMM; cl17107 1114970000402 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114970000403 motif II; other site 1114970000404 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1114970000405 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114970000406 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1114970000407 active site 1114970000408 homodimer interface [polypeptide binding]; other site 1114970000409 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1114970000410 amino acid carrier protein; Region: agcS; TIGR00835 1114970000411 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1114970000412 Aspartase; Region: Aspartase; cd01357 1114970000413 active sites [active] 1114970000414 tetramer interface [polypeptide binding]; other site 1114970000415 cell density-dependent motility repressor; Provisional; Region: PRK10082 1114970000416 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970000417 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1114970000418 dimerization interface [polypeptide binding]; other site 1114970000419 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1114970000420 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1114970000421 ATP-grasp domain; Region: ATP-grasp; pfam02222 1114970000422 Predicted membrane protein [Function unknown]; Region: COG2261 1114970000423 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 1114970000424 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1114970000425 active site 1114970000426 phosphate binding residues; other site 1114970000427 catalytic residues [active] 1114970000428 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1114970000429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970000430 metabolite-proton symporter; Region: 2A0106; TIGR00883 1114970000431 putative substrate translocation pore; other site 1114970000432 PBP superfamily domain; Region: PBP_like_2; cl17296 1114970000433 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 1114970000434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970000435 dimer interface [polypeptide binding]; other site 1114970000436 conserved gate region; other site 1114970000437 putative PBP binding loops; other site 1114970000438 ABC-ATPase subunit interface; other site 1114970000439 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 1114970000440 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1114970000441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970000442 dimer interface [polypeptide binding]; other site 1114970000443 conserved gate region; other site 1114970000444 putative PBP binding loops; other site 1114970000445 ABC-ATPase subunit interface; other site 1114970000446 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 1114970000447 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1114970000448 Walker A/P-loop; other site 1114970000449 ATP binding site [chemical binding]; other site 1114970000450 Q-loop/lid; other site 1114970000451 ABC transporter signature motif; other site 1114970000452 Walker B; other site 1114970000453 D-loop; other site 1114970000454 H-loop/switch region; other site 1114970000455 transcriptional regulator PhoU; Provisional; Region: PRK11115 1114970000456 PhoU domain; Region: PhoU; pfam01895 1114970000457 PhoU domain; Region: PhoU; pfam01895 1114970000458 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1114970000459 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970000460 active site 1114970000461 phosphorylation site [posttranslational modification] 1114970000462 intermolecular recognition site; other site 1114970000463 dimerization interface [polypeptide binding]; other site 1114970000464 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1114970000465 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1114970000466 Peptidase family M23; Region: Peptidase_M23; pfam01551 1114970000467 Domain of unknown function DUF21; Region: DUF21; pfam01595 1114970000468 gliding motility-associated protein GldE; Region: GldE; TIGR03520 1114970000469 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1114970000470 Transporter associated domain; Region: CorC_HlyC; pfam03471 1114970000471 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 1114970000472 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1114970000473 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970000474 putative active site [active] 1114970000475 heme pocket [chemical binding]; other site 1114970000476 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970000477 dimer interface [polypeptide binding]; other site 1114970000478 phosphorylation site [posttranslational modification] 1114970000479 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970000480 ATP binding site [chemical binding]; other site 1114970000481 Mg2+ binding site [ion binding]; other site 1114970000482 G-X-G motif; other site 1114970000483 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 1114970000484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970000485 active site 1114970000486 phosphorylation site [posttranslational modification] 1114970000487 intermolecular recognition site; other site 1114970000488 dimerization interface [polypeptide binding]; other site 1114970000489 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970000490 DNA binding site [nucleotide binding] 1114970000491 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1114970000492 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1114970000493 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 1114970000494 UbiA prenyltransferase family; Region: UbiA; pfam01040 1114970000495 Chorismate lyase; Region: Chor_lyase; cl01230 1114970000496 Rubredoxin [Energy production and conversion]; Region: COG1773 1114970000497 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1114970000498 iron binding site [ion binding]; other site 1114970000499 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 1114970000500 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114970000501 hypothetical protein; Provisional; Region: PRK07236 1114970000502 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1114970000503 IHF dimer interface [polypeptide binding]; other site 1114970000504 IHF - DNA interface [nucleotide binding]; other site 1114970000505 Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023 1114970000506 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 1114970000507 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 1114970000508 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1114970000509 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1114970000510 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 1114970000511 Dodecin; Region: Dodecin; pfam07311 1114970000512 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 1114970000513 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1114970000514 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970000515 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970000516 dimerization interface [polypeptide binding]; other site 1114970000517 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1114970000518 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1114970000519 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970000520 catalytic residue [active] 1114970000521 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1114970000522 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1114970000523 substrate binding site [chemical binding]; other site 1114970000524 active site 1114970000525 catalytic residues [active] 1114970000526 heterodimer interface [polypeptide binding]; other site 1114970000527 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 1114970000528 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 1114970000529 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 1114970000530 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 1114970000531 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1114970000532 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1114970000533 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1114970000534 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1114970000535 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1114970000536 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1114970000537 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1114970000538 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1114970000539 ligand binding site [chemical binding]; other site 1114970000540 homodimer interface [polypeptide binding]; other site 1114970000541 NAD(P) binding site [chemical binding]; other site 1114970000542 trimer interface B [polypeptide binding]; other site 1114970000543 trimer interface A [polypeptide binding]; other site 1114970000544 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1114970000545 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970000546 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 1114970000547 dimerization interface [polypeptide binding]; other site 1114970000548 substrate binding pocket [chemical binding]; other site 1114970000549 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 1114970000550 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1114970000551 FAD binding site [chemical binding]; other site 1114970000552 substrate binding pocket [chemical binding]; other site 1114970000553 catalytic base [active] 1114970000554 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1114970000555 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1114970000556 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 1114970000557 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 1114970000558 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 1114970000559 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114970000560 binding surface 1114970000561 TPR motif; other site 1114970000562 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 1114970000563 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 1114970000564 putative active site [active] 1114970000565 putative metal binding site [ion binding]; other site 1114970000566 N-glycosyltransferase; Provisional; Region: PRK11204 1114970000567 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1114970000568 DXD motif; other site 1114970000569 PgaD-like protein; Region: PgaD; pfam13994 1114970000570 AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The...; Region: Rieske_AIFL_N; cd03478 1114970000571 [2Fe-2S] cluster binding site [ion binding]; other site 1114970000572 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1114970000573 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114970000574 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1114970000575 substrate binding site [chemical binding]; other site 1114970000576 metabolite-proton symporter; Region: 2A0106; TIGR00883 1114970000577 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970000578 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970000579 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970000580 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1114970000581 putative effector binding pocket; other site 1114970000582 dimerization interface [polypeptide binding]; other site 1114970000583 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 1114970000584 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1114970000585 putative NAD(P) binding site [chemical binding]; other site 1114970000586 von Willebrand factor; Region: vWF_A; pfam12450 1114970000587 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1114970000588 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 1114970000589 metal ion-dependent adhesion site (MIDAS); other site 1114970000590 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 1114970000591 RNA polymerase sigma factor; Provisional; Region: PRK12513 1114970000592 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970000593 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114970000594 DNA binding residues [nucleotide binding] 1114970000595 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 1114970000596 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1114970000597 tetramerization interface [polypeptide binding]; other site 1114970000598 NAD(P) binding site [chemical binding]; other site 1114970000599 catalytic residues [active] 1114970000600 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 1114970000601 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114970000602 inhibitor-cofactor binding pocket; inhibition site 1114970000603 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970000604 catalytic residue [active] 1114970000605 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970000606 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970000607 active site 1114970000608 phosphorylation site [posttranslational modification] 1114970000609 intermolecular recognition site; other site 1114970000610 dimerization interface [polypeptide binding]; other site 1114970000611 HDOD domain; Region: HDOD; pfam08668 1114970000612 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970000613 PAS fold; Region: PAS_3; pfam08447 1114970000614 putative active site [active] 1114970000615 heme pocket [chemical binding]; other site 1114970000616 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114970000617 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970000618 metal binding site [ion binding]; metal-binding site 1114970000619 active site 1114970000620 I-site; other site 1114970000621 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1114970000622 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1114970000623 Di-iron ligands [ion binding]; other site 1114970000624 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1114970000625 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1114970000626 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970000627 PAS domain; Region: PAS_9; pfam13426 1114970000628 putative active site [active] 1114970000629 heme pocket [chemical binding]; other site 1114970000630 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114970000631 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970000632 metal binding site [ion binding]; metal-binding site 1114970000633 active site 1114970000634 I-site; other site 1114970000635 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970000636 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1114970000637 MULE transposase domain; Region: MULE; pfam10551 1114970000638 Uncharacterized small protein [Function unknown]; Region: COG5583 1114970000639 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1114970000640 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1114970000641 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1114970000642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970000643 dimer interface [polypeptide binding]; other site 1114970000644 conserved gate region; other site 1114970000645 putative PBP binding loops; other site 1114970000646 ABC-ATPase subunit interface; other site 1114970000647 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1114970000648 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970000649 dimer interface [polypeptide binding]; other site 1114970000650 conserved gate region; other site 1114970000651 putative PBP binding loops; other site 1114970000652 ABC-ATPase subunit interface; other site 1114970000653 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1114970000654 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1114970000655 Walker A/P-loop; other site 1114970000656 ATP binding site [chemical binding]; other site 1114970000657 Q-loop/lid; other site 1114970000658 ABC transporter signature motif; other site 1114970000659 Walker B; other site 1114970000660 D-loop; other site 1114970000661 H-loop/switch region; other site 1114970000662 TOBE-like domain; Region: TOBE_3; pfam12857 1114970000663 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1114970000664 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1114970000665 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1114970000666 Predicted membrane protein [Function unknown]; Region: COG4539 1114970000667 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1114970000668 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1114970000669 ligand binding site [chemical binding]; other site 1114970000670 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1114970000671 putative switch regulator; other site 1114970000672 non-specific DNA interactions [nucleotide binding]; other site 1114970000673 DNA binding site [nucleotide binding] 1114970000674 sequence specific DNA binding site [nucleotide binding]; other site 1114970000675 putative cAMP binding site [chemical binding]; other site 1114970000676 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1114970000677 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114970000678 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970000679 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1114970000680 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1114970000681 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970000682 N-terminal plug; other site 1114970000683 ligand-binding site [chemical binding]; other site 1114970000684 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1114970000685 FecR protein; Region: FecR; pfam04773 1114970000686 RNA polymerase sigma factor; Provisional; Region: PRK12528 1114970000687 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970000688 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114970000689 DNA binding residues [nucleotide binding] 1114970000690 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1114970000691 Cache domain; Region: Cache_1; pfam02743 1114970000692 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970000693 dimerization interface [polypeptide binding]; other site 1114970000694 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970000695 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970000696 dimer interface [polypeptide binding]; other site 1114970000697 putative CheW interface [polypeptide binding]; other site 1114970000698 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1114970000699 putative hydrophobic ligand binding site [chemical binding]; other site 1114970000700 protein interface [polypeptide binding]; other site 1114970000701 gate; other site 1114970000702 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1114970000703 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1114970000704 acyl-activating enzyme (AAE) consensus motif; other site 1114970000705 AMP binding site [chemical binding]; other site 1114970000706 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114970000707 thioester reductase domain; Region: Thioester-redct; TIGR01746 1114970000708 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1114970000709 putative NAD(P) binding site [chemical binding]; other site 1114970000710 active site 1114970000711 putative substrate binding site [chemical binding]; other site 1114970000712 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1114970000713 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 1114970000714 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1114970000715 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970000716 DNA-binding site [nucleotide binding]; DNA binding site 1114970000717 FCD domain; Region: FCD; pfam07729 1114970000718 Predicted transglutaminase-like cysteine proteinase [General function prediction only]; Region: COG3672 1114970000719 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970000720 dimerization interface [polypeptide binding]; other site 1114970000721 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114970000722 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970000723 metal binding site [ion binding]; metal-binding site 1114970000724 active site 1114970000725 I-site; other site 1114970000726 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970000727 Calx-beta domain; Region: Calx-beta; cl02522 1114970000728 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1114970000729 metal ion-dependent adhesion site (MIDAS); other site 1114970000730 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1114970000731 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 1114970000732 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1114970000733 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 1114970000734 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 1114970000735 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1114970000736 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114970000737 Walker A/P-loop; other site 1114970000738 ATP binding site [chemical binding]; other site 1114970000739 Q-loop/lid; other site 1114970000740 ABC transporter signature motif; other site 1114970000741 Walker B; other site 1114970000742 D-loop; other site 1114970000743 H-loop/switch region; other site 1114970000744 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1114970000745 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1114970000746 HlyD family secretion protein; Region: HlyD_3; pfam13437 1114970000747 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1114970000748 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1114970000749 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1114970000750 NMT1-like family; Region: NMT1_2; pfam13379 1114970000751 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1114970000752 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1114970000753 Walker A/P-loop; other site 1114970000754 ATP binding site [chemical binding]; other site 1114970000755 Q-loop/lid; other site 1114970000756 ABC transporter signature motif; other site 1114970000757 Walker B; other site 1114970000758 D-loop; other site 1114970000759 H-loop/switch region; other site 1114970000760 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1114970000761 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970000762 dimer interface [polypeptide binding]; other site 1114970000763 conserved gate region; other site 1114970000764 putative PBP binding loops; other site 1114970000765 ABC-ATPase subunit interface; other site 1114970000766 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1114970000767 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970000768 TIGR01777 family protein; Region: yfcH 1114970000769 NAD(P) binding site [chemical binding]; other site 1114970000770 active site 1114970000771 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114970000772 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1114970000773 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1114970000774 HlyD family secretion protein; Region: HlyD_3; pfam13437 1114970000775 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1114970000776 HlyD family secretion protein; Region: HlyD_3; pfam13437 1114970000777 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1114970000778 active site 1114970000779 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1114970000780 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1114970000781 HlyD family secretion protein; Region: HlyD_3; pfam13437 1114970000782 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970000783 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1114970000784 Coenzyme A binding pocket [chemical binding]; other site 1114970000785 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 1114970000786 Phage Tail Collar Domain; Region: Collar; pfam07484 1114970000787 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1114970000788 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 1114970000789 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1114970000790 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1114970000791 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1114970000792 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1114970000793 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1114970000794 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1114970000795 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 1114970000796 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1114970000797 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1114970000798 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 1114970000799 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 1114970000800 Serine hydrolase; Region: Ser_hydrolase; pfam06821 1114970000801 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114970000802 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970000803 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1114970000804 Walker A motif; other site 1114970000805 ATP binding site [chemical binding]; other site 1114970000806 Walker B motif; other site 1114970000807 arginine finger; other site 1114970000808 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1114970000809 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1114970000810 Predicted ATPase [General function prediction only]; Region: COG4637 1114970000811 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114970000812 Walker A/P-loop; other site 1114970000813 ATP binding site [chemical binding]; other site 1114970000814 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1114970000815 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1114970000816 HlyD family secretion protein; Region: HlyD_3; pfam13437 1114970000817 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1114970000818 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1114970000819 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1114970000820 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1114970000821 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1114970000822 metal-binding site [ion binding] 1114970000823 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1114970000824 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1114970000825 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 1114970000826 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 1114970000827 DNA binding residues [nucleotide binding] 1114970000828 dimer interface [polypeptide binding]; other site 1114970000829 putative metal binding site [ion binding]; other site 1114970000830 thymidylate synthase; Provisional; Region: thyA; PRK13821 1114970000831 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1114970000832 dimerization interface [polypeptide binding]; other site 1114970000833 active site 1114970000834 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1114970000835 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1114970000836 NRDE protein; Region: NRDE; cl01315 1114970000837 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 1114970000838 GAF domain; Region: GAF; pfam01590 1114970000839 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1114970000840 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1114970000841 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1114970000842 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1114970000843 putative active site [active] 1114970000844 Ap4A binding site [chemical binding]; other site 1114970000845 nudix motif; other site 1114970000846 putative metal binding site [ion binding]; other site 1114970000847 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1114970000848 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114970000849 motif II; other site 1114970000850 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 1114970000851 threonine dehydratase; Reviewed; Region: PRK09224 1114970000852 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1114970000853 tetramer interface [polypeptide binding]; other site 1114970000854 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970000855 catalytic residue [active] 1114970000856 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1114970000857 putative Ile/Val binding site [chemical binding]; other site 1114970000858 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1114970000859 putative Ile/Val binding site [chemical binding]; other site 1114970000860 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1114970000861 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1114970000862 active site 1114970000863 dimer interface [polypeptide binding]; other site 1114970000864 SdiA-regulated; Region: SdiA-regulated; pfam06977 1114970000865 SdiA-regulated; Region: SdiA-regulated; cd09971 1114970000866 putative active site [active] 1114970000867 SdiA-regulated; Region: SdiA-regulated; pfam06977 1114970000868 SdiA-regulated; Region: SdiA-regulated; cd09971 1114970000869 putative active site [active] 1114970000870 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1114970000871 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1114970000872 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1114970000873 FAD binding domain; Region: FAD_binding_4; pfam01565 1114970000874 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1114970000875 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1114970000876 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1114970000877 ligand binding site [chemical binding]; other site 1114970000878 NAD binding site [chemical binding]; other site 1114970000879 tetramer interface [polypeptide binding]; other site 1114970000880 catalytic site [active] 1114970000881 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1114970000882 L-serine binding site [chemical binding]; other site 1114970000883 ACT domain interface; other site 1114970000884 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 1114970000885 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1114970000886 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970000887 substrate binding pocket [chemical binding]; other site 1114970000888 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970000889 hinge residues; other site 1114970000890 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1114970000891 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970000892 S-adenosylmethionine binding site [chemical binding]; other site 1114970000893 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970000894 dimer interface [polypeptide binding]; other site 1114970000895 conserved gate region; other site 1114970000896 ABC-ATPase subunit interface; other site 1114970000897 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1114970000898 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1114970000899 Walker A/P-loop; other site 1114970000900 ATP binding site [chemical binding]; other site 1114970000901 Q-loop/lid; other site 1114970000902 ABC transporter signature motif; other site 1114970000903 Walker B; other site 1114970000904 D-loop; other site 1114970000905 H-loop/switch region; other site 1114970000906 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1114970000907 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1114970000908 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1114970000909 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1114970000910 active site 1114970000911 non-prolyl cis peptide bond; other site 1114970000912 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1114970000913 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 1114970000914 Flavin binding site [chemical binding]; other site 1114970000915 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1114970000916 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1114970000917 active site 1114970000918 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 1114970000919 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1114970000920 Walker A/P-loop; other site 1114970000921 ATP binding site [chemical binding]; other site 1114970000922 Q-loop/lid; other site 1114970000923 ABC transporter signature motif; other site 1114970000924 Walker B; other site 1114970000925 D-loop; other site 1114970000926 H-loop/switch region; other site 1114970000927 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970000928 dimer interface [polypeptide binding]; other site 1114970000929 conserved gate region; other site 1114970000930 putative PBP binding loops; other site 1114970000931 ABC-ATPase subunit interface; other site 1114970000932 cystine transporter subunit; Provisional; Region: PRK11260 1114970000933 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970000934 substrate binding pocket [chemical binding]; other site 1114970000935 membrane-bound complex binding site; other site 1114970000936 hinge residues; other site 1114970000937 D-cysteine desulfhydrase; Validated; Region: PRK03910 1114970000938 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1114970000939 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114970000940 catalytic residue [active] 1114970000941 BCCT family transporter; Region: BCCT; cl00569 1114970000942 short chain dehydrogenase; Provisional; Region: PRK12937 1114970000943 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1114970000944 NADP binding site [chemical binding]; other site 1114970000945 homodimer interface [polypeptide binding]; other site 1114970000946 active site 1114970000947 substrate binding site [chemical binding]; other site 1114970000948 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970000949 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970000950 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1114970000951 putative effector binding pocket; other site 1114970000952 putative dimerization interface [polypeptide binding]; other site 1114970000953 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114970000954 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1114970000955 active site 1114970000956 catalytic tetrad [active] 1114970000957 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 1114970000958 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1114970000959 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1114970000960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970000961 dimer interface [polypeptide binding]; other site 1114970000962 conserved gate region; other site 1114970000963 putative PBP binding loops; other site 1114970000964 ABC-ATPase subunit interface; other site 1114970000965 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 1114970000966 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1114970000967 Walker A/P-loop; other site 1114970000968 ATP binding site [chemical binding]; other site 1114970000969 Q-loop/lid; other site 1114970000970 ABC transporter signature motif; other site 1114970000971 Walker B; other site 1114970000972 D-loop; other site 1114970000973 H-loop/switch region; other site 1114970000974 taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729 1114970000975 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970000976 substrate binding pocket [chemical binding]; other site 1114970000977 membrane-bound complex binding site; other site 1114970000978 hinge residues; other site 1114970000979 glutamate--cysteine ligase; Provisional; Region: PRK02107 1114970000980 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1114970000981 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1114970000982 CoenzymeA binding site [chemical binding]; other site 1114970000983 subunit interaction site [polypeptide binding]; other site 1114970000984 PHB binding site; other site 1114970000985 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1114970000986 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1114970000987 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1114970000988 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1114970000989 RNA binding site [nucleotide binding]; other site 1114970000990 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1114970000991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970000992 active site 1114970000993 phosphorylation site [posttranslational modification] 1114970000994 intermolecular recognition site; other site 1114970000995 dimerization interface [polypeptide binding]; other site 1114970000996 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970000997 DNA binding site [nucleotide binding] 1114970000998 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 1114970000999 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970001000 dimerization interface [polypeptide binding]; other site 1114970001001 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970001002 ATP binding site [chemical binding]; other site 1114970001003 Mg2+ binding site [ion binding]; other site 1114970001004 G-X-G motif; other site 1114970001005 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1114970001006 RimK-like ATP-grasp domain; Region: RimK; pfam08443 1114970001007 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 1114970001008 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1114970001009 RNA binding surface [nucleotide binding]; other site 1114970001010 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1114970001011 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1114970001012 dimerization interface [polypeptide binding]; other site 1114970001013 domain crossover interface; other site 1114970001014 redox-dependent activation switch; other site 1114970001015 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1114970001016 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1114970001017 active site 1114970001018 substrate-binding site [chemical binding]; other site 1114970001019 metal-binding site [ion binding] 1114970001020 ATP binding site [chemical binding]; other site 1114970001021 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1114970001022 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1114970001023 Helix-turn-helix domain; Region: HTH_31; pfam13560 1114970001024 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1114970001025 S-type Pyocin; Region: Pyocin_S; pfam06958 1114970001026 Cytotoxic; Region: Cytotoxic; pfam09000 1114970001027 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1114970001028 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114970001029 ATP binding site [chemical binding]; other site 1114970001030 putative Mg++ binding site [ion binding]; other site 1114970001031 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114970001032 nucleotide binding region [chemical binding]; other site 1114970001033 ATP-binding site [chemical binding]; other site 1114970001034 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1114970001035 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1114970001036 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1114970001037 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1114970001038 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1114970001039 active site 1114970001040 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1114970001041 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1114970001042 putative molybdopterin cofactor binding site [chemical binding]; other site 1114970001043 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1114970001044 putative molybdopterin cofactor binding site; other site 1114970001045 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 1114970001046 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970001047 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970001048 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1114970001049 dimerization interface [polypeptide binding]; other site 1114970001050 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1114970001051 BON domain; Region: BON; pfam04972 1114970001052 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114970001053 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1114970001054 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114970001055 motif II; other site 1114970001056 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 1114970001057 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1114970001058 dimer interface [polypeptide binding]; other site 1114970001059 ADP-ribose binding site [chemical binding]; other site 1114970001060 active site 1114970001061 nudix motif; other site 1114970001062 metal binding site [ion binding]; metal-binding site 1114970001063 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1114970001064 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1114970001065 active site 1114970001066 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 1114970001067 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1114970001068 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970001069 active site 1114970001070 phosphorylation site [posttranslational modification] 1114970001071 intermolecular recognition site; other site 1114970001072 dimerization interface [polypeptide binding]; other site 1114970001073 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970001074 Walker A motif; other site 1114970001075 ATP binding site [chemical binding]; other site 1114970001076 Walker B motif; other site 1114970001077 arginine finger; other site 1114970001078 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1114970001079 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1114970001080 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970001081 dimer interface [polypeptide binding]; other site 1114970001082 phosphorylation site [posttranslational modification] 1114970001083 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970001084 ATP binding site [chemical binding]; other site 1114970001085 G-X-G motif; other site 1114970001086 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1114970001087 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1114970001088 NADP binding site [chemical binding]; other site 1114970001089 active site 1114970001090 putative substrate binding site [chemical binding]; other site 1114970001091 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 1114970001092 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1114970001093 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1114970001094 substrate binding site; other site 1114970001095 tetramer interface; other site 1114970001096 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 1114970001097 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1114970001098 NAD binding site [chemical binding]; other site 1114970001099 substrate binding site [chemical binding]; other site 1114970001100 homodimer interface [polypeptide binding]; other site 1114970001101 active site 1114970001102 hypothetical protein; Provisional; Region: PRK06149 1114970001103 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1114970001104 active site 1114970001105 ATP binding site [chemical binding]; other site 1114970001106 substrate binding site [chemical binding]; other site 1114970001107 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114970001108 inhibitor-cofactor binding pocket; inhibition site 1114970001109 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970001110 catalytic residue [active] 1114970001111 agmatine deiminase; Provisional; Region: PRK13551 1114970001112 agmatine deiminase; Region: agmatine_aguA; TIGR03380 1114970001113 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 1114970001114 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1114970001115 catalytic residues [active] 1114970001116 outer membrane porin, OprD family; Region: OprD; pfam03573 1114970001117 Biofilm formation and stress response factor; Region: BsmA; pfam10014 1114970001118 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970001119 Coenzyme A binding pocket [chemical binding]; other site 1114970001120 AzlC protein; Region: AzlC; cl00570 1114970001121 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970001122 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970001123 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970001124 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 1114970001125 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 1114970001126 RES domain; Region: RES; smart00953 1114970001127 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1114970001128 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970001129 dimerization interface [polypeptide binding]; other site 1114970001130 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970001131 dimer interface [polypeptide binding]; other site 1114970001132 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1114970001133 putative CheW interface [polypeptide binding]; other site 1114970001134 Protein of unknown function (DUF3077); Region: DUF3077; pfam11275 1114970001135 TIGR04255 family protein; Region: sporadTIGR04255 1114970001136 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1114970001137 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1114970001138 active site 1114970001139 Int/Topo IB signature motif; other site 1114970001140 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1114970001141 Methyltransferase domain; Region: Methyltransf_32; pfam13679 1114970001142 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114970001143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970001144 dimer interface [polypeptide binding]; other site 1114970001145 conserved gate region; other site 1114970001146 putative PBP binding loops; other site 1114970001147 ABC-ATPase subunit interface; other site 1114970001148 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114970001149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970001150 dimer interface [polypeptide binding]; other site 1114970001151 conserved gate region; other site 1114970001152 putative PBP binding loops; other site 1114970001153 ABC-ATPase subunit interface; other site 1114970001154 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970001155 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970001156 substrate binding pocket [chemical binding]; other site 1114970001157 membrane-bound complex binding site; other site 1114970001158 hinge residues; other site 1114970001159 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1114970001160 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1114970001161 Walker A/P-loop; other site 1114970001162 ATP binding site [chemical binding]; other site 1114970001163 Q-loop/lid; other site 1114970001164 ABC transporter signature motif; other site 1114970001165 Walker B; other site 1114970001166 D-loop; other site 1114970001167 H-loop/switch region; other site 1114970001168 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 1114970001169 oxidative damage protection protein; Provisional; Region: PRK05408 1114970001170 adenine DNA glycosylase; Provisional; Region: PRK10880 1114970001171 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1114970001172 minor groove reading motif; other site 1114970001173 helix-hairpin-helix signature motif; other site 1114970001174 substrate binding pocket [chemical binding]; other site 1114970001175 active site 1114970001176 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1114970001177 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1114970001178 DNA binding and oxoG recognition site [nucleotide binding] 1114970001179 AsmA family; Region: AsmA; pfam05170 1114970001180 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1114970001181 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 1114970001182 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970001183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970001184 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1114970001185 putative active site pocket [active] 1114970001186 4-fold oligomerization interface [polypeptide binding]; other site 1114970001187 metal binding residues [ion binding]; metal-binding site 1114970001188 3-fold/trimer interface [polypeptide binding]; other site 1114970001189 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1114970001190 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1114970001191 putative active site [active] 1114970001192 oxyanion strand; other site 1114970001193 catalytic triad [active] 1114970001194 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 1114970001195 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1114970001196 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1114970001197 catalytic residues [active] 1114970001198 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1114970001199 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1114970001200 substrate binding site [chemical binding]; other site 1114970001201 glutamase interaction surface [polypeptide binding]; other site 1114970001202 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970001203 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970001204 substrate binding pocket [chemical binding]; other site 1114970001205 membrane-bound complex binding site; other site 1114970001206 hinge residues; other site 1114970001207 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1114970001208 NodB motif; other site 1114970001209 putative active site [active] 1114970001210 putative catalytic site [active] 1114970001211 Zn binding site [ion binding]; other site 1114970001212 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1114970001213 C-terminal peptidase (prc); Region: prc; TIGR00225 1114970001214 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1114970001215 protein binding site [polypeptide binding]; other site 1114970001216 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1114970001217 Catalytic dyad [active] 1114970001218 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 1114970001219 Peptidase family M23; Region: Peptidase_M23; pfam01551 1114970001220 phosphoglyceromutase; Provisional; Region: PRK05434 1114970001221 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1114970001222 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1114970001223 active site residue [active] 1114970001224 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1114970001225 GSH binding site [chemical binding]; other site 1114970001226 catalytic residues [active] 1114970001227 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 1114970001228 SecA binding site; other site 1114970001229 Preprotein binding site; other site 1114970001230 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1114970001231 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 1114970001232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970001233 active site 1114970001234 phosphorylation site [posttranslational modification] 1114970001235 intermolecular recognition site; other site 1114970001236 dimerization interface [polypeptide binding]; other site 1114970001237 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970001238 Walker A motif; other site 1114970001239 ATP binding site [chemical binding]; other site 1114970001240 Walker B motif; other site 1114970001241 arginine finger; other site 1114970001242 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1114970001243 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1114970001244 PAS domain; Region: PAS; smart00091 1114970001245 putative active site [active] 1114970001246 heme pocket [chemical binding]; other site 1114970001247 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970001248 dimer interface [polypeptide binding]; other site 1114970001249 phosphorylation site [posttranslational modification] 1114970001250 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970001251 ATP binding site [chemical binding]; other site 1114970001252 Mg2+ binding site [ion binding]; other site 1114970001253 G-X-G motif; other site 1114970001254 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1114970001255 chorismate mutase; Provisional; Region: PRK09269 1114970001256 Chorismate mutase type II; Region: CM_2; cl00693 1114970001257 glutamine synthetase; Provisional; Region: glnA; PRK09469 1114970001258 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1114970001259 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1114970001260 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 1114970001261 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1114970001262 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1114970001263 Ligand Binding Site [chemical binding]; other site 1114970001264 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1114970001265 active site residue [active] 1114970001266 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1114970001267 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1114970001268 G1 box; other site 1114970001269 putative GEF interaction site [polypeptide binding]; other site 1114970001270 GTP/Mg2+ binding site [chemical binding]; other site 1114970001271 Switch I region; other site 1114970001272 G2 box; other site 1114970001273 G3 box; other site 1114970001274 Switch II region; other site 1114970001275 G4 box; other site 1114970001276 G5 box; other site 1114970001277 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1114970001278 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1114970001279 Flagellin N-methylase; Region: FliB; pfam03692 1114970001280 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1114970001281 homodimer interface [polypeptide binding]; other site 1114970001282 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1114970001283 active site pocket [active] 1114970001284 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 1114970001285 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 1114970001286 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 1114970001287 fructose-1,6-bisphosphatase family protein; Region: PLN02628 1114970001288 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1114970001289 AMP binding site [chemical binding]; other site 1114970001290 metal binding site [ion binding]; metal-binding site 1114970001291 active site 1114970001292 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 1114970001293 Cache domain; Region: Cache_1; pfam02743 1114970001294 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970001295 dimerization interface [polypeptide binding]; other site 1114970001296 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970001297 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970001298 dimer interface [polypeptide binding]; other site 1114970001299 putative CheW interface [polypeptide binding]; other site 1114970001300 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 1114970001301 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1114970001302 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 1114970001303 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 1114970001304 active site 1114970001305 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 1114970001306 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970001307 DNA-binding site [nucleotide binding]; DNA binding site 1114970001308 UTRA domain; Region: UTRA; pfam07702 1114970001309 HutD; Region: HutD; pfam05962 1114970001310 urocanate hydratase; Provisional; Region: PRK05414 1114970001311 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 1114970001312 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1114970001313 Na binding site [ion binding]; other site 1114970001314 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1114970001315 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1114970001316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970001317 dimer interface [polypeptide binding]; other site 1114970001318 conserved gate region; other site 1114970001319 putative PBP binding loops; other site 1114970001320 ABC-ATPase subunit interface; other site 1114970001321 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1114970001322 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1114970001323 Walker A/P-loop; other site 1114970001324 ATP binding site [chemical binding]; other site 1114970001325 Q-loop/lid; other site 1114970001326 ABC transporter signature motif; other site 1114970001327 Walker B; other site 1114970001328 D-loop; other site 1114970001329 H-loop/switch region; other site 1114970001330 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1114970001331 active sites [active] 1114970001332 tetramer interface [polypeptide binding]; other site 1114970001333 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1114970001334 active sites [active] 1114970001335 tetramer interface [polypeptide binding]; other site 1114970001336 imidazolonepropionase; Validated; Region: PRK09356 1114970001337 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1114970001338 active site 1114970001339 N-formylglutamate amidohydrolase; Region: FGase; cl01522 1114970001340 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1114970001341 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 1114970001342 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1114970001343 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1114970001344 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1114970001345 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1114970001346 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1114970001347 putative active site [active] 1114970001348 dimerization interface [polypeptide binding]; other site 1114970001349 putative tRNAtyr binding site [nucleotide binding]; other site 1114970001350 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 1114970001351 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 1114970001352 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1114970001353 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 1114970001354 Ligand binding site; other site 1114970001355 DXD motif; other site 1114970001356 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970001357 dimerization interface [polypeptide binding]; other site 1114970001358 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970001359 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970001360 dimer interface [polypeptide binding]; other site 1114970001361 putative CheW interface [polypeptide binding]; other site 1114970001362 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1114970001363 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1114970001364 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970001365 dimerization interface [polypeptide binding]; other site 1114970001366 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970001367 dimer interface [polypeptide binding]; other site 1114970001368 putative CheW interface [polypeptide binding]; other site 1114970001369 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1114970001370 RNA methyltransferase, RsmE family; Region: TIGR00046 1114970001371 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 1114970001372 sec-independent translocase; Provisional; Region: tatB; PRK00404 1114970001373 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 1114970001374 twin arginine translocase protein A; Provisional; Region: tatA; PRK00442 1114970001375 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1114970001376 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1114970001377 metal binding site [ion binding]; metal-binding site 1114970001378 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1114970001379 ABC1 family; Region: ABC1; cl17513 1114970001380 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1114970001381 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 1114970001382 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1114970001383 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1114970001384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970001385 S-adenosylmethionine binding site [chemical binding]; other site 1114970001386 putative polyhydroxyalkanoic acid system protein; Region: PHA_gran_rgn; TIGR02610 1114970001387 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597 1114970001388 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597 1114970001389 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970001390 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114970001391 Bacterial transcriptional repressor; Region: TetR; pfam13972 1114970001392 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 1114970001393 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1114970001394 poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240 1114970001395 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1114970001396 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 1114970001397 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1114970001398 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 1114970001399 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1114970001400 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970001401 Walker A motif; other site 1114970001402 ATP binding site [chemical binding]; other site 1114970001403 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1114970001404 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1114970001405 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1114970001406 active site 1114970001407 HslU subunit interaction site [polypeptide binding]; other site 1114970001408 Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087 1114970001409 Sporulation related domain; Region: SPOR; pfam05036 1114970001410 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1114970001411 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1114970001412 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1114970001413 active site 1114970001414 HIGH motif; other site 1114970001415 KMSK motif region; other site 1114970001416 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1114970001417 tRNA binding surface [nucleotide binding]; other site 1114970001418 anticodon binding site; other site 1114970001419 primosome assembly protein PriA; Validated; Region: PRK05580 1114970001420 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114970001421 ATP binding site [chemical binding]; other site 1114970001422 putative Mg++ binding site [ion binding]; other site 1114970001423 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1114970001424 ATP-binding site [chemical binding]; other site 1114970001425 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1114970001426 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1114970001427 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1114970001428 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1114970001429 putative NAD(P) binding site [chemical binding]; other site 1114970001430 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 1114970001431 Transglycosylase; Region: Transgly; pfam00912 1114970001432 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1114970001433 Competence protein A; Region: Competence_A; pfam11104 1114970001434 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1114970001435 nucleotide binding site [chemical binding]; other site 1114970001436 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 1114970001437 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1114970001438 Tfp pilus assembly protein PilO [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilO; COG3167 1114970001439 Pilus assembly protein, PilP; Region: PilP; pfam04351 1114970001440 AMIN domain; Region: AMIN; pfam11741 1114970001441 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 1114970001442 Secretin and TonB N terminus short domain; Region: STN; smart00965 1114970001443 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1114970001444 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1114970001445 shikimate kinase; Reviewed; Region: aroK; PRK00131 1114970001446 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1114970001447 ADP binding site [chemical binding]; other site 1114970001448 magnesium binding site [ion binding]; other site 1114970001449 putative shikimate binding site; other site 1114970001450 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1114970001451 active site 1114970001452 dimer interface [polypeptide binding]; other site 1114970001453 metal binding site [ion binding]; metal-binding site 1114970001454 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 1114970001455 Sporulation related domain; Region: SPOR; pfam05036 1114970001456 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1114970001457 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1114970001458 active site 1114970001459 dimer interface [polypeptide binding]; other site 1114970001460 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1114970001461 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1114970001462 active site 1114970001463 FMN binding site [chemical binding]; other site 1114970001464 substrate binding site [chemical binding]; other site 1114970001465 3Fe-4S cluster binding site [ion binding]; other site 1114970001466 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1114970001467 domain interface; other site 1114970001468 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 1114970001469 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1114970001470 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1114970001471 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1114970001472 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1114970001473 substrate binding site [chemical binding]; other site 1114970001474 active site 1114970001475 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 1114970001476 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1114970001477 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1114970001478 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 1114970001479 type II secretion system protein D; Region: type_II_gspD; TIGR02517 1114970001480 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1114970001481 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1114970001482 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1114970001483 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1114970001484 type II secretion system protein E; Region: type_II_gspE; TIGR02533 1114970001485 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1114970001486 Walker A motif; other site 1114970001487 ATP binding site [chemical binding]; other site 1114970001488 Walker B motif; other site 1114970001489 type II secretion system protein F; Region: GspF; TIGR02120 1114970001490 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1114970001491 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1114970001492 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1114970001493 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1114970001494 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1114970001495 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 1114970001496 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 1114970001497 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1114970001498 type II secretion system protein J; Region: gspJ; TIGR01711 1114970001499 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 1114970001500 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 1114970001501 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 1114970001502 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 1114970001503 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 1114970001504 GspL periplasmic domain; Region: GspL_C; pfam12693 1114970001505 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 1114970001506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970001507 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970001508 putative substrate translocation pore; other site 1114970001509 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1114970001510 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970001511 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1114970001512 dimerization interface [polypeptide binding]; other site 1114970001513 substrate binding pocket [chemical binding]; other site 1114970001514 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1114970001515 PGAP1-like protein; Region: PGAP1; pfam07819 1114970001516 PAAR motif; Region: PAAR_motif; pfam05488 1114970001517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970001518 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970001519 putative substrate translocation pore; other site 1114970001520 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1114970001521 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1114970001522 substrate binding pocket [chemical binding]; other site 1114970001523 active site 1114970001524 iron coordination sites [ion binding]; other site 1114970001525 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1114970001526 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114970001527 non-specific DNA binding site [nucleotide binding]; other site 1114970001528 salt bridge; other site 1114970001529 sequence-specific DNA binding site [nucleotide binding]; other site 1114970001530 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 1114970001531 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1114970001532 Ligand Binding Site [chemical binding]; other site 1114970001533 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 1114970001534 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1114970001535 dimer interface [polypeptide binding]; other site 1114970001536 active site 1114970001537 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1114970001538 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 1114970001539 NAD(P) binding site [chemical binding]; other site 1114970001540 homotetramer interface [polypeptide binding]; other site 1114970001541 homodimer interface [polypeptide binding]; other site 1114970001542 active site 1114970001543 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 1114970001544 putative active site 1 [active] 1114970001545 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 1114970001546 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1114970001547 dimer interface [polypeptide binding]; other site 1114970001548 active site 1114970001549 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1114970001550 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970001551 S-adenosylmethionine binding site [chemical binding]; other site 1114970001552 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1114970001553 Predicted exporter [General function prediction only]; Region: COG4258 1114970001554 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 1114970001555 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1114970001556 active site 1114970001557 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1114970001558 active sites [active] 1114970001559 tetramer interface [polypeptide binding]; other site 1114970001560 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1114970001561 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1114970001562 putative acyl-acceptor binding pocket; other site 1114970001563 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1114970001564 Ligand binding site; other site 1114970001565 Putative Catalytic site; other site 1114970001566 DXD motif; other site 1114970001567 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1114970001568 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1114970001569 active site 1114970001570 AMP binding site [chemical binding]; other site 1114970001571 acyl-activating enzyme (AAE) consensus motif; other site 1114970001572 CoA binding site [chemical binding]; other site 1114970001573 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 1114970001574 active site 2 [active] 1114970001575 dimer interface [polypeptide binding]; other site 1114970001576 active site 1 [active] 1114970001577 Predicted membrane protein [Function unknown]; Region: COG4648 1114970001578 acyl carrier protein; Provisional; Region: PRK05350 1114970001579 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114970001580 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1114970001581 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1114970001582 putative acyl-acceptor binding pocket; other site 1114970001583 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 1114970001584 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1114970001585 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1114970001586 P-loop; other site 1114970001587 Magnesium ion binding site [ion binding]; other site 1114970001588 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1114970001589 Magnesium ion binding site [ion binding]; other site 1114970001590 thioredoxin 2; Provisional; Region: PRK10996 1114970001591 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1114970001592 catalytic residues [active] 1114970001593 Isochorismatase family; Region: Isochorismatase; pfam00857 1114970001594 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1114970001595 catalytic triad [active] 1114970001596 dimer interface [polypeptide binding]; other site 1114970001597 conserved cis-peptide bond; other site 1114970001598 LysR family transcriptional regulator; Provisional; Region: PRK14997 1114970001599 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970001600 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 1114970001601 putative effector binding pocket; other site 1114970001602 putative dimerization interface [polypeptide binding]; other site 1114970001603 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 1114970001604 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114970001605 non-specific DNA binding site [nucleotide binding]; other site 1114970001606 salt bridge; other site 1114970001607 sequence-specific DNA binding site [nucleotide binding]; other site 1114970001608 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1114970001609 hypothetical protein; Validated; Region: PRK00029 1114970001610 hypothetical protein; Provisional; Region: PRK11281 1114970001611 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1114970001612 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1114970001613 potassium/proton antiporter; Reviewed; Region: PRK05326 1114970001614 TrkA-C domain; Region: TrkA_C; pfam02080 1114970001615 Transporter associated domain; Region: CorC_HlyC; smart01091 1114970001616 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1114970001617 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970001618 dimerization interface [polypeptide binding]; other site 1114970001619 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970001620 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970001621 dimer interface [polypeptide binding]; other site 1114970001622 putative CheW interface [polypeptide binding]; other site 1114970001623 Cell division protein ZapA; Region: ZapA; pfam05164 1114970001624 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1114970001625 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1114970001626 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1114970001627 active site 1114970001628 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1114970001629 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 1114970001630 Predicted transcriptional regulator [Transcription]; Region: COG3905 1114970001631 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1114970001632 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1114970001633 Glutamate binding site [chemical binding]; other site 1114970001634 NAD binding site [chemical binding]; other site 1114970001635 catalytic residues [active] 1114970001636 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1114970001637 Na binding site [ion binding]; other site 1114970001638 Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933 1114970001639 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1114970001640 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1114970001641 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1114970001642 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 1114970001643 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1114970001644 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1114970001645 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1114970001646 GAF domain; Region: GAF; pfam01590 1114970001647 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970001648 PAS domain; Region: PAS_9; pfam13426 1114970001649 putative active site [active] 1114970001650 heme pocket [chemical binding]; other site 1114970001651 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114970001652 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970001653 metal binding site [ion binding]; metal-binding site 1114970001654 active site 1114970001655 I-site; other site 1114970001656 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970001657 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1114970001658 putative active site [active] 1114970001659 putative metal binding site [ion binding]; other site 1114970001660 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 1114970001661 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1114970001662 E3 interaction surface; other site 1114970001663 lipoyl attachment site [posttranslational modification]; other site 1114970001664 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1114970001665 E3 interaction surface; other site 1114970001666 lipoyl attachment site [posttranslational modification]; other site 1114970001667 e3 binding domain; Region: E3_binding; pfam02817 1114970001668 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1114970001669 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1114970001670 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1114970001671 dimer interface [polypeptide binding]; other site 1114970001672 TPP-binding site [chemical binding]; other site 1114970001673 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1114970001674 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1114970001675 metal binding triad; other site 1114970001676 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1114970001677 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1114970001678 metal binding triad; other site 1114970001679 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1114970001680 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1114970001681 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1114970001682 putative active site [active] 1114970001683 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1114970001684 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1114970001685 putative active site [active] 1114970001686 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114970001687 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1114970001688 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 1114970001689 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 1114970001690 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 1114970001691 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 1114970001692 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 1114970001693 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1114970001694 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1114970001695 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114970001696 putative ADP-binding pocket [chemical binding]; other site 1114970001697 Mig-14; Region: Mig-14; pfam07395 1114970001698 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1114970001699 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 1114970001700 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114970001701 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1114970001702 Sm and related proteins; Region: Sm_like; cl00259 1114970001703 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1114970001704 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114970001705 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1114970001706 active site 1114970001707 substrate binding site [chemical binding]; other site 1114970001708 ATP binding site [chemical binding]; other site 1114970001709 O-Antigen ligase; Region: Wzy_C; pfam04932 1114970001710 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 1114970001711 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1114970001712 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1114970001713 Walker A/P-loop; other site 1114970001714 ATP binding site [chemical binding]; other site 1114970001715 Q-loop/lid; other site 1114970001716 ABC transporter signature motif; other site 1114970001717 Walker B; other site 1114970001718 D-loop; other site 1114970001719 H-loop/switch region; other site 1114970001720 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 1114970001721 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1114970001722 ligand-binding site [chemical binding]; other site 1114970001723 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 1114970001724 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1114970001725 putative ribose interaction site [chemical binding]; other site 1114970001726 putative ADP binding site [chemical binding]; other site 1114970001727 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1114970001728 active site 1114970001729 nucleotide binding site [chemical binding]; other site 1114970001730 HIGH motif; other site 1114970001731 KMSKS motif; other site 1114970001732 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114970001733 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1114970001734 active site 1114970001735 catalytic tetrad [active] 1114970001736 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1114970001737 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1114970001738 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1114970001739 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970001740 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970001741 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1114970001742 dimerization interface [polypeptide binding]; other site 1114970001743 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1114970001744 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1114970001745 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1114970001746 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1114970001747 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1114970001748 ThiC-associated domain; Region: ThiC-associated; pfam13667 1114970001749 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1114970001750 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1114970001751 Na binding site [ion binding]; other site 1114970001752 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1114970001753 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 1114970001754 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1114970001755 dimer interface [polypeptide binding]; other site 1114970001756 ADP-ribose binding site [chemical binding]; other site 1114970001757 active site 1114970001758 nudix motif; other site 1114970001759 metal binding site [ion binding]; metal-binding site 1114970001760 Protein of unknown function (DUF1249); Region: DUF1249; pfam06853 1114970001761 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1114970001762 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1114970001763 active site 1114970001764 metal binding site [ion binding]; metal-binding site 1114970001765 hexamer interface [polypeptide binding]; other site 1114970001766 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 1114970001767 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114970001768 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1114970001769 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970001770 ATP binding site [chemical binding]; other site 1114970001771 Mg2+ binding site [ion binding]; other site 1114970001772 G-X-G motif; other site 1114970001773 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1114970001774 anchoring element; other site 1114970001775 dimer interface [polypeptide binding]; other site 1114970001776 ATP binding site [chemical binding]; other site 1114970001777 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1114970001778 active site 1114970001779 metal binding site [ion binding]; metal-binding site 1114970001780 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1114970001781 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 1114970001782 catalytic motif [active] 1114970001783 Catalytic residue [active] 1114970001784 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1114970001785 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1114970001786 CAP-like domain; other site 1114970001787 active site 1114970001788 primary dimer interface [polypeptide binding]; other site 1114970001789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 1114970001790 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1114970001791 Bacterial virulence factor haemolysin; Region: SMP_2; cl11479 1114970001792 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1114970001793 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1114970001794 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1114970001795 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114970001796 motif II; other site 1114970001797 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1114970001798 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1114970001799 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1114970001800 active site residue [active] 1114970001801 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1114970001802 active site residue [active] 1114970001803 HDOD domain; Region: HDOD; pfam08668 1114970001804 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1114970001805 flagellar motor protein MotA; Validated; Region: PRK09110 1114970001806 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1114970001807 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1114970001808 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1114970001809 ligand binding site [chemical binding]; other site 1114970001810 GTPase RsgA; Reviewed; Region: PRK12288 1114970001811 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1114970001812 RNA binding site [nucleotide binding]; other site 1114970001813 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1114970001814 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1114970001815 GTP/Mg2+ binding site [chemical binding]; other site 1114970001816 G4 box; other site 1114970001817 G5 box; other site 1114970001818 G1 box; other site 1114970001819 Switch I region; other site 1114970001820 G2 box; other site 1114970001821 G3 box; other site 1114970001822 Switch II region; other site 1114970001823 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1114970001824 catalytic site [active] 1114970001825 putative active site [active] 1114970001826 putative substrate binding site [chemical binding]; other site 1114970001827 dimer interface [polypeptide binding]; other site 1114970001828 Predicted membrane protein [Function unknown]; Region: COG2860 1114970001829 UPF0126 domain; Region: UPF0126; pfam03458 1114970001830 UPF0126 domain; Region: UPF0126; pfam03458 1114970001831 epoxyqueuosine reductase; Region: TIGR00276 1114970001832 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1114970001833 putative carbohydrate kinase; Provisional; Region: PRK10565 1114970001834 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1114970001835 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1114970001836 putative substrate binding site [chemical binding]; other site 1114970001837 putative ATP binding site [chemical binding]; other site 1114970001838 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 1114970001839 AMIN domain; Region: AMIN; pfam11741 1114970001840 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1114970001841 active site 1114970001842 metal binding site [ion binding]; metal-binding site 1114970001843 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1114970001844 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114970001845 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1114970001846 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970001847 ATP binding site [chemical binding]; other site 1114970001848 Mg2+ binding site [ion binding]; other site 1114970001849 G-X-G motif; other site 1114970001850 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1114970001851 ATP binding site [chemical binding]; other site 1114970001852 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1114970001853 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1114970001854 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1114970001855 bacterial Hfq-like; Region: Hfq; cd01716 1114970001856 Sm1 motif; other site 1114970001857 RNA binding site [nucleotide binding]; other site 1114970001858 hexamer interface [polypeptide binding]; other site 1114970001859 Sm2 motif; other site 1114970001860 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1114970001861 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1114970001862 HflX GTPase family; Region: HflX; cd01878 1114970001863 G1 box; other site 1114970001864 GTP/Mg2+ binding site [chemical binding]; other site 1114970001865 Switch I region; other site 1114970001866 G2 box; other site 1114970001867 G3 box; other site 1114970001868 Switch II region; other site 1114970001869 G4 box; other site 1114970001870 G5 box; other site 1114970001871 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 1114970001872 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1114970001873 HflK protein; Region: hflK; TIGR01933 1114970001874 HflC protein; Region: hflC; TIGR01932 1114970001875 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1114970001876 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 1114970001877 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1114970001878 dimer interface [polypeptide binding]; other site 1114970001879 motif 1; other site 1114970001880 active site 1114970001881 motif 2; other site 1114970001882 motif 3; other site 1114970001883 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1114970001884 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1114970001885 GDP-binding site [chemical binding]; other site 1114970001886 ACT binding site; other site 1114970001887 IMP binding site; other site 1114970001888 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1114970001889 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970001890 dimerization interface [polypeptide binding]; other site 1114970001891 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970001892 dimer interface [polypeptide binding]; other site 1114970001893 putative CheW interface [polypeptide binding]; other site 1114970001894 ribonuclease R; Region: RNase_R; TIGR02063 1114970001895 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1114970001896 RNB domain; Region: RNB; pfam00773 1114970001897 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1114970001898 RNA binding site [nucleotide binding]; other site 1114970001899 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1114970001900 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1114970001901 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1114970001902 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1114970001903 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1114970001904 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1114970001905 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1114970001906 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1114970001907 replicative DNA helicase; Provisional; Region: PRK05748 1114970001908 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1114970001909 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1114970001910 Walker A motif; other site 1114970001911 ATP binding site [chemical binding]; other site 1114970001912 Walker B motif; other site 1114970001913 DNA binding loops [nucleotide binding] 1114970001914 hypothetical protein; Provisional; Region: PRK01254 1114970001915 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 1114970001916 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 1114970001917 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1114970001918 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1114970001919 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1114970001920 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 1114970001921 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 1114970001922 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1114970001923 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1114970001924 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1114970001925 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1114970001926 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1114970001927 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1114970001928 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1114970001929 azurin; Region: azurin; TIGR02695 1114970001930 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1114970001931 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1114970001932 homodimer interface [polypeptide binding]; other site 1114970001933 NAD binding pocket [chemical binding]; other site 1114970001934 ATP binding pocket [chemical binding]; other site 1114970001935 Mg binding site [ion binding]; other site 1114970001936 active-site loop [active] 1114970001937 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 1114970001938 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 1114970001939 active site 1114970001940 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1114970001941 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970001942 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 1114970001943 dimerization interface [polypeptide binding]; other site 1114970001944 substrate binding pocket [chemical binding]; other site 1114970001945 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1114970001946 aldehyde dehydrogenase family 7 member; Region: PLN02315 1114970001947 tetrameric interface [polypeptide binding]; other site 1114970001948 NAD binding site [chemical binding]; other site 1114970001949 catalytic residues [active] 1114970001950 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1114970001951 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1114970001952 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1114970001953 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1114970001954 dimerization interface [polypeptide binding]; other site 1114970001955 ligand binding site [chemical binding]; other site 1114970001956 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1114970001957 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1114970001958 TM-ABC transporter signature motif; other site 1114970001959 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1114970001960 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1114970001961 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1114970001962 TM-ABC transporter signature motif; other site 1114970001963 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1114970001964 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1114970001965 Walker A/P-loop; other site 1114970001966 ATP binding site [chemical binding]; other site 1114970001967 Q-loop/lid; other site 1114970001968 ABC transporter signature motif; other site 1114970001969 Walker B; other site 1114970001970 D-loop; other site 1114970001971 H-loop/switch region; other site 1114970001972 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1114970001973 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1114970001974 Walker A/P-loop; other site 1114970001975 ATP binding site [chemical binding]; other site 1114970001976 Q-loop/lid; other site 1114970001977 ABC transporter signature motif; other site 1114970001978 Walker B; other site 1114970001979 D-loop; other site 1114970001980 H-loop/switch region; other site 1114970001981 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1114970001982 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 1114970001983 putative NAD(P) binding site [chemical binding]; other site 1114970001984 homotetramer interface [polypeptide binding]; other site 1114970001985 homodimer interface [polypeptide binding]; other site 1114970001986 active site 1114970001987 dimerization interface [polypeptide binding]; other site 1114970001988 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1114970001989 putative active cleft [active] 1114970001990 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 1114970001991 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1114970001992 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1114970001993 UreF; Region: UreF; pfam01730 1114970001994 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1114970001995 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1114970001996 dimer interface [polypeptide binding]; other site 1114970001997 catalytic residues [active] 1114970001998 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1114970001999 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114970002000 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1114970002001 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1114970002002 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1114970002003 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1114970002004 Ferritin-like domain; Region: Ferritin; pfam00210 1114970002005 dinuclear metal binding motif [ion binding]; other site 1114970002006 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970002007 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970002008 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970002009 dimerization interface [polypeptide binding]; other site 1114970002010 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1114970002011 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1114970002012 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1114970002013 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1114970002014 hypothetical protein; Provisional; Region: PRK11505 1114970002015 psiF repeat; Region: PsiF_repeat; pfam07769 1114970002016 psiF repeat; Region: PsiF_repeat; pfam07769 1114970002017 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1114970002018 putative chaperone; Provisional; Region: PRK11678 1114970002019 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 1114970002020 nucleotide binding site [chemical binding]; other site 1114970002021 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1114970002022 SBD interface [polypeptide binding]; other site 1114970002023 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1114970002024 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1114970002025 HSP70 interaction site [polypeptide binding]; other site 1114970002026 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1114970002027 substrate binding site [polypeptide binding]; other site 1114970002028 dimer interface [polypeptide binding]; other site 1114970002029 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 1114970002030 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 1114970002031 Leucine rich repeat; Region: LRR_8; pfam13855 1114970002032 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1114970002033 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1114970002034 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1114970002035 subunit interactions [polypeptide binding]; other site 1114970002036 active site 1114970002037 flap region; other site 1114970002038 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1114970002039 gamma-beta subunit interface [polypeptide binding]; other site 1114970002040 alpha-beta subunit interface [polypeptide binding]; other site 1114970002041 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1114970002042 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970002043 Coenzyme A binding pocket [chemical binding]; other site 1114970002044 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1114970002045 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970002046 Coenzyme A binding pocket [chemical binding]; other site 1114970002047 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1114970002048 alpha-gamma subunit interface [polypeptide binding]; other site 1114970002049 beta-gamma subunit interface [polypeptide binding]; other site 1114970002050 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 1114970002051 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1114970002052 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1114970002053 Walker A/P-loop; other site 1114970002054 ATP binding site [chemical binding]; other site 1114970002055 Q-loop/lid; other site 1114970002056 ABC transporter signature motif; other site 1114970002057 Walker B; other site 1114970002058 D-loop; other site 1114970002059 H-loop/switch region; other site 1114970002060 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1114970002061 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1114970002062 Walker A/P-loop; other site 1114970002063 ATP binding site [chemical binding]; other site 1114970002064 Q-loop/lid; other site 1114970002065 ABC transporter signature motif; other site 1114970002066 Walker B; other site 1114970002067 D-loop; other site 1114970002068 H-loop/switch region; other site 1114970002069 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1114970002070 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1114970002071 TM-ABC transporter signature motif; other site 1114970002072 HEAT repeats; Region: HEAT_2; pfam13646 1114970002073 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1114970002074 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1114970002075 TM-ABC transporter signature motif; other site 1114970002076 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1114970002077 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1114970002078 putative ligand binding site [chemical binding]; other site 1114970002079 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1114970002080 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114970002081 ABC-ATPase subunit interface; other site 1114970002082 dimer interface [polypeptide binding]; other site 1114970002083 putative PBP binding regions; other site 1114970002084 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 1114970002085 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1114970002086 putative ligand binding residues [chemical binding]; other site 1114970002087 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1114970002088 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1114970002089 Walker A/P-loop; other site 1114970002090 ATP binding site [chemical binding]; other site 1114970002091 Q-loop/lid; other site 1114970002092 ABC transporter signature motif; other site 1114970002093 Walker B; other site 1114970002094 D-loop; other site 1114970002095 H-loop/switch region; other site 1114970002096 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1114970002097 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1114970002098 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1114970002099 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1114970002100 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970002101 N-terminal plug; other site 1114970002102 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 1114970002103 ligand-binding site [chemical binding]; other site 1114970002104 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 1114970002105 Protein of unknown function (DUF461); Region: DUF461; pfam04314 1114970002106 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 1114970002107 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1114970002108 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1114970002109 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 1114970002110 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 1114970002111 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1114970002112 active site 1114970002113 putative homodimer interface [polypeptide binding]; other site 1114970002114 SAM binding site [chemical binding]; other site 1114970002115 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1114970002116 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970002117 S-adenosylmethionine binding site [chemical binding]; other site 1114970002118 precorrin-3B synthase; Region: CobG; TIGR02435 1114970002119 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1114970002120 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1114970002121 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1114970002122 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1114970002123 active site 1114970002124 SAM binding site [chemical binding]; other site 1114970002125 homodimer interface [polypeptide binding]; other site 1114970002126 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 1114970002127 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 1114970002128 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 1114970002129 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1114970002130 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1114970002131 active site 1114970002132 SAM binding site [chemical binding]; other site 1114970002133 homodimer interface [polypeptide binding]; other site 1114970002134 TcdA/TcdB catalytic glycosyltransferase domain; Region: TcdA_TcdB; pfam12919 1114970002135 TcdA/TcdB pore forming domain; Region: TcdA_TcdB_pore; pfam12920 1114970002136 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 1114970002137 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1114970002138 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1114970002139 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970002140 dimer interface [polypeptide binding]; other site 1114970002141 phosphorylation site [posttranslational modification] 1114970002142 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970002143 ATP binding site [chemical binding]; other site 1114970002144 Mg2+ binding site [ion binding]; other site 1114970002145 G-X-G motif; other site 1114970002146 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970002147 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970002148 active site 1114970002149 phosphorylation site [posttranslational modification] 1114970002150 intermolecular recognition site; other site 1114970002151 dimerization interface [polypeptide binding]; other site 1114970002152 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970002153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970002154 active site 1114970002155 phosphorylation site [posttranslational modification] 1114970002156 intermolecular recognition site; other site 1114970002157 dimerization interface [polypeptide binding]; other site 1114970002158 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1114970002159 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1114970002160 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1114970002161 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1114970002162 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1114970002163 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1114970002164 purine monophosphate binding site [chemical binding]; other site 1114970002165 dimer interface [polypeptide binding]; other site 1114970002166 putative catalytic residues [active] 1114970002167 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1114970002168 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1114970002169 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 1114970002170 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 1114970002171 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1114970002172 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1114970002173 FMN binding site [chemical binding]; other site 1114970002174 active site 1114970002175 catalytic residues [active] 1114970002176 substrate binding site [chemical binding]; other site 1114970002177 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 1114970002178 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 1114970002179 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1114970002180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970002181 S-adenosylmethionine binding site [chemical binding]; other site 1114970002182 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1114970002183 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1114970002184 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1114970002185 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1114970002186 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1114970002187 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1114970002188 carboxyltransferase (CT) interaction site; other site 1114970002189 biotinylation site [posttranslational modification]; other site 1114970002190 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1114970002191 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1114970002192 active site 1114970002193 trimer interface [polypeptide binding]; other site 1114970002194 dimer interface [polypeptide binding]; other site 1114970002195 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970002196 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970002197 dimer interface [polypeptide binding]; other site 1114970002198 putative CheW interface [polypeptide binding]; other site 1114970002199 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 1114970002200 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970002201 active site 1114970002202 phosphorylation site [posttranslational modification] 1114970002203 intermolecular recognition site; other site 1114970002204 dimerization interface [polypeptide binding]; other site 1114970002205 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970002206 metal binding site [ion binding]; metal-binding site 1114970002207 active site 1114970002208 I-site; other site 1114970002209 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; pfam10095 1114970002210 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1114970002211 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 1114970002212 nudix motif; other site 1114970002213 translation initiation factor Sui1; Validated; Region: PRK06824 1114970002214 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1114970002215 putative rRNA binding site [nucleotide binding]; other site 1114970002216 arginine decarboxylase; Provisional; Region: PRK05354 1114970002217 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1114970002218 dimer interface [polypeptide binding]; other site 1114970002219 active site 1114970002220 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1114970002221 catalytic residues [active] 1114970002222 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1114970002223 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1114970002224 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1114970002225 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 1114970002226 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 1114970002227 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1114970002228 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 1114970002229 homodimer interface [polypeptide binding]; other site 1114970002230 chemical substrate binding site [chemical binding]; other site 1114970002231 oligomer interface [polypeptide binding]; other site 1114970002232 metal binding site [ion binding]; metal-binding site 1114970002233 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970002234 S-adenosylmethionine binding site [chemical binding]; other site 1114970002235 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 1114970002236 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 1114970002237 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1114970002238 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1114970002239 active site 2 [active] 1114970002240 active site 1 [active] 1114970002241 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 1114970002242 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970002243 NAD(P) binding site [chemical binding]; other site 1114970002244 active site 1114970002245 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 1114970002246 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1114970002247 dimer interface [polypeptide binding]; other site 1114970002248 active site 1114970002249 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1114970002250 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1114970002251 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1114970002252 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970002253 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970002254 Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718 1114970002255 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 1114970002256 ATP binding site [chemical binding]; other site 1114970002257 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1114970002258 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1114970002259 DNA binding residues [nucleotide binding] 1114970002260 dimer interface [polypeptide binding]; other site 1114970002261 copper binding site [ion binding]; other site 1114970002262 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1114970002263 metal-binding site [ion binding] 1114970002264 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1114970002265 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1114970002266 metal-binding site [ion binding] 1114970002267 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1114970002268 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1114970002269 metal-binding site [ion binding] 1114970002270 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970002271 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1114970002272 putative substrate translocation pore; other site 1114970002273 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1114970002274 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1114970002275 putative NAD(P) binding site [chemical binding]; other site 1114970002276 dimer interface [polypeptide binding]; other site 1114970002277 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970002278 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970002279 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1114970002280 putative effector binding pocket; other site 1114970002281 dimerization interface [polypeptide binding]; other site 1114970002282 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114970002283 putative DNA binding site [nucleotide binding]; other site 1114970002284 putative Zn2+ binding site [ion binding]; other site 1114970002285 benzoate transport; Region: 2A0115; TIGR00895 1114970002286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970002287 putative substrate translocation pore; other site 1114970002288 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970002289 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1114970002290 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1114970002291 active site 1114970002292 purine riboside binding site [chemical binding]; other site 1114970002293 oxidase reductase; Provisional; Region: PTZ00273 1114970002294 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1114970002295 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1114970002296 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1114970002297 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1114970002298 putative ligand binding site [chemical binding]; other site 1114970002299 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 1114970002300 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1114970002301 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 1114970002302 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1114970002303 active site 1114970002304 putative substrate binding pocket [chemical binding]; other site 1114970002305 C factor cell-cell signaling protein; Provisional; Region: PRK09009 1114970002306 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 1114970002307 NADP binding site [chemical binding]; other site 1114970002308 homodimer interface [polypeptide binding]; other site 1114970002309 active site 1114970002310 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1114970002311 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1114970002312 DNA binding residues [nucleotide binding] 1114970002313 dimer interface [polypeptide binding]; other site 1114970002314 metal binding site [ion binding]; metal-binding site 1114970002315 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1114970002316 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1114970002317 TM-ABC transporter signature motif; other site 1114970002318 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1114970002319 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1114970002320 TM-ABC transporter signature motif; other site 1114970002321 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1114970002322 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1114970002323 Walker A/P-loop; other site 1114970002324 ATP binding site [chemical binding]; other site 1114970002325 Q-loop/lid; other site 1114970002326 ABC transporter signature motif; other site 1114970002327 Walker B; other site 1114970002328 D-loop; other site 1114970002329 H-loop/switch region; other site 1114970002330 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1114970002331 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1114970002332 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1114970002333 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1114970002334 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1114970002335 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114970002336 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1114970002337 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970002338 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970002339 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1114970002340 dimerization interface [polypeptide binding]; other site 1114970002341 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 1114970002342 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114970002343 inhibitor-cofactor binding pocket; inhibition site 1114970002344 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970002345 catalytic residue [active] 1114970002346 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1114970002347 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1114970002348 tetrameric interface [polypeptide binding]; other site 1114970002349 NAD binding site [chemical binding]; other site 1114970002350 catalytic residues [active] 1114970002351 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1114970002352 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 1114970002353 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 1114970002354 Part of AAA domain; Region: AAA_19; pfam13245 1114970002355 Family description; Region: UvrD_C_2; pfam13538 1114970002356 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1114970002357 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1114970002358 AAA domain; Region: AAA_30; pfam13604 1114970002359 Family description; Region: UvrD_C_2; pfam13538 1114970002360 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 1114970002361 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114970002362 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970002363 metal binding site [ion binding]; metal-binding site 1114970002364 active site 1114970002365 I-site; other site 1114970002366 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1114970002367 ligand binding site [chemical binding]; other site 1114970002368 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970002369 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970002370 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1114970002371 dimerization interface [polypeptide binding]; other site 1114970002372 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1114970002373 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1114970002374 tetrameric interface [polypeptide binding]; other site 1114970002375 NAD binding site [chemical binding]; other site 1114970002376 catalytic residues [active] 1114970002377 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1114970002378 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1114970002379 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 1114970002380 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970002381 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970002382 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 1114970002383 putative dimerization interface [polypeptide binding]; other site 1114970002384 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1114970002385 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1114970002386 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970002387 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970002388 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970002389 dimerization interface [polypeptide binding]; other site 1114970002390 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1114970002391 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1114970002392 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1114970002393 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1114970002394 GntP family permease; Region: GntP_permease; pfam02447 1114970002395 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1114970002396 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1114970002397 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1114970002398 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1114970002399 putative active site [active] 1114970002400 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1114970002401 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1114970002402 active site 1114970002403 putative substrate binding pocket [chemical binding]; other site 1114970002404 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 1114970002405 dimer interface [polypeptide binding]; other site 1114970002406 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114970002407 ligand binding site [chemical binding]; other site 1114970002408 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1114970002409 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1114970002410 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 1114970002411 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 1114970002412 Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255 1114970002413 Salmonella virulence plasmid 28.1kDa A protein; Region: VRP1; pfam03538 1114970002414 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1114970002415 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970002416 dimerization interface [polypeptide binding]; other site 1114970002417 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970002418 dimer interface [polypeptide binding]; other site 1114970002419 putative CheW interface [polypeptide binding]; other site 1114970002420 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 1114970002421 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 1114970002422 active site 1114970002423 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1114970002424 ligand binding site [chemical binding]; other site 1114970002425 flagellar motor protein MotA; Validated; Region: PRK08124 1114970002426 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1114970002427 flagellin; Validated; Region: PRK06819 1114970002428 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1114970002429 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1114970002430 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114970002431 binding surface 1114970002432 TPR motif; other site 1114970002433 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1114970002434 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114970002435 TPR motif; other site 1114970002436 binding surface 1114970002437 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1114970002438 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1114970002439 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1114970002440 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1114970002441 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1114970002442 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 1114970002443 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970002444 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1114970002445 DNA binding residues [nucleotide binding] 1114970002446 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 1114970002447 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723 1114970002448 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1114970002449 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1114970002450 FHIPEP family; Region: FHIPEP; pfam00771 1114970002451 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1114970002452 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1114970002453 flagellar motor protein MotB; Validated; Region: motB; PRK09041 1114970002454 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1114970002455 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1114970002456 ligand binding site [chemical binding]; other site 1114970002457 flagellar motor protein MotA; Validated; Region: PRK09110 1114970002458 transcriptional activator FlhC; Provisional; Region: PRK12722 1114970002459 Flagellar transcriptional activator (FlhD); Region: FlhD; pfam05247 1114970002460 Flagellar protein FliT; Region: FliT; pfam05400 1114970002461 Flagellar protein FliS; Region: FliS; cl00654 1114970002462 flagellar capping protein; Reviewed; Region: fliD; PRK08032 1114970002463 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1114970002464 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 1114970002465 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1114970002466 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1114970002467 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1114970002468 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1114970002469 FliG C-terminal domain; Region: FliG_C; pfam01706 1114970002470 flagellar assembly protein H; Validated; Region: fliH; PRK05687 1114970002471 Flagellar assembly protein FliH; Region: FliH; pfam02108 1114970002472 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 1114970002473 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1114970002474 Walker A motif/ATP binding site; other site 1114970002475 Walker B motif; other site 1114970002476 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 1114970002477 Flagellar FliJ protein; Region: FliJ; pfam02050 1114970002478 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 1114970002479 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 1114970002480 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1114970002481 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1114970002482 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1114970002483 flagellar motor switch protein; Validated; Region: fliN; PRK05698 1114970002484 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 1114970002485 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1114970002486 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1114970002487 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1114970002488 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 1114970002489 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1114970002490 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 1114970002491 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1114970002492 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 1114970002493 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 1114970002494 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 1114970002495 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1114970002496 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1114970002497 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 1114970002498 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 1114970002499 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1114970002500 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1114970002501 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1114970002502 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 1114970002503 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1114970002504 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1114970002505 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1114970002506 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1114970002507 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1114970002508 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1114970002509 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1114970002510 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1114970002511 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1114970002512 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1114970002513 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1114970002514 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1114970002515 SAF-like; Region: SAF_2; pfam13144 1114970002516 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1114970002517 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 1114970002518 FlgN protein; Region: FlgN; pfam05130 1114970002519 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1114970002520 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1114970002521 dimer interface [polypeptide binding]; other site 1114970002522 active site 1114970002523 heme binding site [chemical binding]; other site 1114970002524 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1114970002525 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1114970002526 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1114970002527 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1114970002528 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1114970002529 Walker A/P-loop; other site 1114970002530 ATP binding site [chemical binding]; other site 1114970002531 Q-loop/lid; other site 1114970002532 ABC transporter signature motif; other site 1114970002533 Walker B; other site 1114970002534 D-loop; other site 1114970002535 H-loop/switch region; other site 1114970002536 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114970002537 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1114970002538 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1114970002539 Walker A/P-loop; other site 1114970002540 ATP binding site [chemical binding]; other site 1114970002541 Q-loop/lid; other site 1114970002542 ABC transporter signature motif; other site 1114970002543 Walker B; other site 1114970002544 D-loop; other site 1114970002545 H-loop/switch region; other site 1114970002546 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114970002547 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1114970002548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970002549 dimer interface [polypeptide binding]; other site 1114970002550 conserved gate region; other site 1114970002551 putative PBP binding loops; other site 1114970002552 ABC-ATPase subunit interface; other site 1114970002553 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1114970002554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970002555 dimer interface [polypeptide binding]; other site 1114970002556 conserved gate region; other site 1114970002557 putative PBP binding loops; other site 1114970002558 ABC-ATPase subunit interface; other site 1114970002559 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1114970002560 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1114970002561 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114970002562 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970002563 DNA binding residues [nucleotide binding] 1114970002564 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1114970002565 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1114970002566 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1114970002567 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1114970002568 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1114970002569 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1114970002570 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1114970002571 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1114970002572 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1114970002573 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1114970002574 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1114970002575 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1114970002576 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1114970002577 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 1114970002578 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1114970002579 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1114970002580 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1114970002581 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1114970002582 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1114970002583 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1114970002584 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1114970002585 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1114970002586 Transposase; Region: HTH_Tnp_1; pfam01527 1114970002587 Domain of unknown function (DUF1910); Region: DUF1910; pfam08928 1114970002588 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 1114970002589 Fic family protein [Function unknown]; Region: COG3177 1114970002590 Fic/DOC family; Region: Fic; pfam02661 1114970002591 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1114970002592 MULE transposase domain; Region: MULE; pfam10551 1114970002593 short chain dehydrogenase; Provisional; Region: PRK06180 1114970002594 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1114970002595 NADP binding site [chemical binding]; other site 1114970002596 active site 1114970002597 steroid binding site; other site 1114970002598 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1114970002599 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1114970002600 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970002601 2-isopropylmalate synthase; Validated; Region: PRK03739 1114970002602 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1114970002603 active site 1114970002604 catalytic residues [active] 1114970002605 metal binding site [ion binding]; metal-binding site 1114970002606 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1114970002607 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1114970002608 addiction module antidote protein, HigA family; Region: antidote_HigA; TIGR02607 1114970002609 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 1114970002610 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1114970002611 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1114970002612 conserved cys residue [active] 1114970002613 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970002614 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970002615 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970002616 substrate binding pocket [chemical binding]; other site 1114970002617 membrane-bound complex binding site; other site 1114970002618 hinge residues; other site 1114970002619 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1114970002620 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1114970002621 Walker A/P-loop; other site 1114970002622 ATP binding site [chemical binding]; other site 1114970002623 Q-loop/lid; other site 1114970002624 ABC transporter signature motif; other site 1114970002625 Walker B; other site 1114970002626 D-loop; other site 1114970002627 H-loop/switch region; other site 1114970002628 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114970002629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970002630 dimer interface [polypeptide binding]; other site 1114970002631 conserved gate region; other site 1114970002632 putative PBP binding loops; other site 1114970002633 ABC-ATPase subunit interface; other site 1114970002634 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114970002635 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970002636 dimer interface [polypeptide binding]; other site 1114970002637 conserved gate region; other site 1114970002638 putative PBP binding loops; other site 1114970002639 ABC-ATPase subunit interface; other site 1114970002640 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1114970002641 Amidase; Region: Amidase; cl11426 1114970002642 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1114970002643 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1114970002644 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1114970002645 homotrimer interaction site [polypeptide binding]; other site 1114970002646 putative active site [active] 1114970002647 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1114970002648 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1114970002649 Predicted transcriptional regulators [Transcription]; Region: COG1733 1114970002650 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1114970002651 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970002652 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970002653 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970002654 dimerization interface [polypeptide binding]; other site 1114970002655 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1114970002656 classical (c) SDRs; Region: SDR_c; cd05233 1114970002657 NAD(P) binding site [chemical binding]; other site 1114970002658 active site 1114970002659 hypothetical protein; Provisional; Region: PRK06847 1114970002660 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1114970002661 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1114970002662 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1114970002663 histidinol dehydrogenase; Region: hisD; TIGR00069 1114970002664 NAD binding site [chemical binding]; other site 1114970002665 dimerization interface [polypeptide binding]; other site 1114970002666 product binding site; other site 1114970002667 substrate binding site [chemical binding]; other site 1114970002668 zinc binding site [ion binding]; other site 1114970002669 catalytic residues [active] 1114970002670 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1114970002671 classical (c) SDRs; Region: SDR_c; cd05233 1114970002672 NAD(P) binding site [chemical binding]; other site 1114970002673 active site 1114970002674 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114970002675 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1114970002676 active site 1114970002677 metal binding site [ion binding]; metal-binding site 1114970002678 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1114970002679 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1114970002680 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1114970002681 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970002682 NAD(P) binding site [chemical binding]; other site 1114970002683 active site 1114970002684 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970002685 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970002686 putative substrate translocation pore; other site 1114970002687 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 1114970002688 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1114970002689 classical (c) SDRs; Region: SDR_c; cd05233 1114970002690 NAD(P) binding site [chemical binding]; other site 1114970002691 active site 1114970002692 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 1114970002693 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 1114970002694 putative active site [active] 1114970002695 putative metal binding site [ion binding]; other site 1114970002696 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114970002697 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1114970002698 Integrase; Region: Integrase_1; pfam12835 1114970002699 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 1114970002700 integrase; Provisional; Region: PRK09692 1114970002701 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1114970002702 active site 1114970002703 Int/Topo IB signature motif; other site 1114970002704 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1114970002705 FAD binding domain; Region: FAD_binding_4; pfam01565 1114970002706 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1114970002707 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1114970002708 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1114970002709 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1114970002710 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1114970002711 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1114970002712 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1114970002713 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1114970002714 Cysteine-rich domain; Region: CCG; pfam02754 1114970002715 Cysteine-rich domain; Region: CCG; pfam02754 1114970002716 glycolate transporter; Provisional; Region: PRK09695 1114970002717 L-lactate permease; Region: Lactate_perm; cl00701 1114970002718 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1114970002719 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970002720 DNA-binding site [nucleotide binding]; DNA binding site 1114970002721 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1114970002722 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1114970002723 SmpB-tmRNA interface; other site 1114970002724 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1114970002725 Na2 binding site [ion binding]; other site 1114970002726 putative substrate binding site 1 [chemical binding]; other site 1114970002727 Na binding site 1 [ion binding]; other site 1114970002728 putative substrate binding site 2 [chemical binding]; other site 1114970002729 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1114970002730 putative coenzyme Q binding site [chemical binding]; other site 1114970002731 RnfH family Ubiquitin; Region: Ub-RnfH; cl17382 1114970002732 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 1114970002733 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 1114970002734 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1114970002735 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1114970002736 metal binding site 2 [ion binding]; metal-binding site 1114970002737 putative DNA binding helix; other site 1114970002738 metal binding site 1 [ion binding]; metal-binding site 1114970002739 dimer interface [polypeptide binding]; other site 1114970002740 structural Zn2+ binding site [ion binding]; other site 1114970002741 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1114970002742 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1114970002743 Walker A/P-loop; other site 1114970002744 ATP binding site [chemical binding]; other site 1114970002745 Q-loop/lid; other site 1114970002746 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1114970002747 ABC transporter signature motif; other site 1114970002748 Walker B; other site 1114970002749 D-loop; other site 1114970002750 H-loop/switch region; other site 1114970002751 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1114970002752 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1114970002753 dimer interface [polypeptide binding]; other site 1114970002754 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1114970002755 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1114970002756 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1114970002757 nucleotide binding site [chemical binding]; other site 1114970002758 chaperone protein DnaJ; Provisional; Region: PRK10767 1114970002759 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1114970002760 HSP70 interaction site [polypeptide binding]; other site 1114970002761 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1114970002762 substrate binding site [polypeptide binding]; other site 1114970002763 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1114970002764 Zn binding sites [ion binding]; other site 1114970002765 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1114970002766 dimer interface [polypeptide binding]; other site 1114970002767 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1114970002768 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1114970002769 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1114970002770 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1114970002771 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1114970002772 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1114970002773 catalytic site [active] 1114970002774 subunit interface [polypeptide binding]; other site 1114970002775 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1114970002776 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1114970002777 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1114970002778 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1114970002779 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1114970002780 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1114970002781 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1114970002782 IMP binding site; other site 1114970002783 dimer interface [polypeptide binding]; other site 1114970002784 interdomain contacts; other site 1114970002785 partial ornithine binding site; other site 1114970002786 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1114970002787 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1114970002788 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1114970002789 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 1114970002790 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1114970002791 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970002792 S-adenosylmethionine binding site [chemical binding]; other site 1114970002793 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 1114970002794 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970002795 Walker A motif; other site 1114970002796 ATP binding site [chemical binding]; other site 1114970002797 Walker B motif; other site 1114970002798 arginine finger; other site 1114970002799 Peptidase family M41; Region: Peptidase_M41; pfam01434 1114970002800 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1114970002801 dihydropteroate synthase; Region: DHPS; TIGR01496 1114970002802 substrate binding pocket [chemical binding]; other site 1114970002803 dimer interface [polypeptide binding]; other site 1114970002804 inhibitor binding site; inhibition site 1114970002805 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1114970002806 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1114970002807 active site 1114970002808 substrate binding site [chemical binding]; other site 1114970002809 metal binding site [ion binding]; metal-binding site 1114970002810 triosephosphate isomerase; Provisional; Region: PRK14567 1114970002811 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1114970002812 substrate binding site [chemical binding]; other site 1114970002813 dimer interface [polypeptide binding]; other site 1114970002814 catalytic triad [active] 1114970002815 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1114970002816 Sm and related proteins; Region: Sm_like; cl00259 1114970002817 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1114970002818 putative oligomer interface [polypeptide binding]; other site 1114970002819 putative RNA binding site [nucleotide binding]; other site 1114970002820 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1114970002821 NusA N-terminal domain; Region: NusA_N; pfam08529 1114970002822 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1114970002823 RNA binding site [nucleotide binding]; other site 1114970002824 homodimer interface [polypeptide binding]; other site 1114970002825 NusA-like KH domain; Region: KH_5; pfam13184 1114970002826 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1114970002827 G-X-X-G motif; other site 1114970002828 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1114970002829 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1114970002830 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1114970002831 translation initiation factor IF-2; Region: IF-2; TIGR00487 1114970002832 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1114970002833 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1114970002834 G1 box; other site 1114970002835 putative GEF interaction site [polypeptide binding]; other site 1114970002836 GTP/Mg2+ binding site [chemical binding]; other site 1114970002837 Switch I region; other site 1114970002838 G2 box; other site 1114970002839 G3 box; other site 1114970002840 Switch II region; other site 1114970002841 G4 box; other site 1114970002842 G5 box; other site 1114970002843 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1114970002844 Translation-initiation factor 2; Region: IF-2; pfam11987 1114970002845 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1114970002846 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1114970002847 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1114970002848 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1114970002849 RNA binding site [nucleotide binding]; other site 1114970002850 active site 1114970002851 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1114970002852 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1114970002853 16S/18S rRNA binding site [nucleotide binding]; other site 1114970002854 S13e-L30e interaction site [polypeptide binding]; other site 1114970002855 25S rRNA binding site [nucleotide binding]; other site 1114970002856 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1114970002857 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1114970002858 RNase E interface [polypeptide binding]; other site 1114970002859 trimer interface [polypeptide binding]; other site 1114970002860 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1114970002861 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1114970002862 RNase E interface [polypeptide binding]; other site 1114970002863 trimer interface [polypeptide binding]; other site 1114970002864 active site 1114970002865 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1114970002866 putative nucleic acid binding region [nucleotide binding]; other site 1114970002867 G-X-X-G motif; other site 1114970002868 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1114970002869 RNA binding site [nucleotide binding]; other site 1114970002870 domain interface; other site 1114970002871 Uncharacterized conserved protein [Function unknown]; Region: COG2433 1114970002872 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05742 1114970002873 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1114970002874 dimerization interface [polypeptide binding]; other site 1114970002875 active site 1114970002876 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793 1114970002877 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1114970002878 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1114970002879 amidase catalytic site [active] 1114970002880 Zn binding residues [ion binding]; other site 1114970002881 substrate binding site [chemical binding]; other site 1114970002882 Membrane protein required for beta-lactamase induction [Defense mechanisms]; Region: AmpE; cl17896 1114970002883 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1114970002884 dimerization interface [polypeptide binding]; other site 1114970002885 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970002886 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970002887 dimer interface [polypeptide binding]; other site 1114970002888 putative CheW interface [polypeptide binding]; other site 1114970002889 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1114970002890 active site 1114970002891 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 1114970002892 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114970002893 DNA binding site [nucleotide binding] 1114970002894 domain linker motif; other site 1114970002895 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1114970002896 dimerization interface [polypeptide binding]; other site 1114970002897 ligand binding site [chemical binding]; other site 1114970002898 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 1114970002899 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1114970002900 active site 1114970002901 phosphorylation site [posttranslational modification] 1114970002902 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 1114970002903 active site 1114970002904 phosphorylation site [posttranslational modification] 1114970002905 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1114970002906 regulatory protein interface [polypeptide binding]; other site 1114970002907 active site 1114970002908 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1114970002909 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1114970002910 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1114970002911 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1114970002912 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1114970002913 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1114970002914 putative substrate binding site [chemical binding]; other site 1114970002915 putative ATP binding site [chemical binding]; other site 1114970002916 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1114970002917 active site 1114970002918 P-loop; other site 1114970002919 phosphorylation site [posttranslational modification] 1114970002920 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 1114970002921 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1114970002922 active site 1114970002923 P-loop; other site 1114970002924 phosphorylation site [posttranslational modification] 1114970002925 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 1114970002926 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 1114970002927 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1114970002928 putative active site [active] 1114970002929 putative metal binding site [ion binding]; other site 1114970002930 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1114970002931 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1114970002932 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1114970002933 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1114970002934 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1114970002935 Flavodoxin; Region: Flavodoxin_1; pfam00258 1114970002936 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 1114970002937 FAD binding pocket [chemical binding]; other site 1114970002938 FAD binding motif [chemical binding]; other site 1114970002939 catalytic residues [active] 1114970002940 NAD binding pocket [chemical binding]; other site 1114970002941 phosphate binding motif [ion binding]; other site 1114970002942 beta-alpha-beta structure motif; other site 1114970002943 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1114970002944 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 1114970002945 dimer interface [polypeptide binding]; other site 1114970002946 active site 1114970002947 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1114970002948 catalytic residues [active] 1114970002949 substrate binding site [chemical binding]; other site 1114970002950 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1114970002951 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1114970002952 Walker A/P-loop; other site 1114970002953 ATP binding site [chemical binding]; other site 1114970002954 Q-loop/lid; other site 1114970002955 ABC transporter signature motif; other site 1114970002956 Walker B; other site 1114970002957 D-loop; other site 1114970002958 H-loop/switch region; other site 1114970002959 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1114970002960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970002961 dimer interface [polypeptide binding]; other site 1114970002962 conserved gate region; other site 1114970002963 ABC-ATPase subunit interface; other site 1114970002964 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1114970002965 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1114970002966 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970002967 ABC-ATPase subunit interface; other site 1114970002968 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1114970002969 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1114970002970 G1 box; other site 1114970002971 putative GEF interaction site [polypeptide binding]; other site 1114970002972 GTP/Mg2+ binding site [chemical binding]; other site 1114970002973 Switch I region; other site 1114970002974 G2 box; other site 1114970002975 G3 box; other site 1114970002976 Switch II region; other site 1114970002977 G4 box; other site 1114970002978 G5 box; other site 1114970002979 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1114970002980 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1114970002981 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1114970002982 Walker A/P-loop; other site 1114970002983 ATP binding site [chemical binding]; other site 1114970002984 Q-loop/lid; other site 1114970002985 ABC transporter signature motif; other site 1114970002986 Walker B; other site 1114970002987 D-loop; other site 1114970002988 H-loop/switch region; other site 1114970002989 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1114970002990 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 1114970002991 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1114970002992 Walker A/P-loop; other site 1114970002993 ATP binding site [chemical binding]; other site 1114970002994 Q-loop/lid; other site 1114970002995 ABC transporter signature motif; other site 1114970002996 Walker B; other site 1114970002997 D-loop; other site 1114970002998 H-loop/switch region; other site 1114970002999 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114970003000 dipeptide transporter; Provisional; Region: PRK10913 1114970003001 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1114970003002 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970003003 dimer interface [polypeptide binding]; other site 1114970003004 conserved gate region; other site 1114970003005 putative PBP binding loops; other site 1114970003006 ABC-ATPase subunit interface; other site 1114970003007 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1114970003008 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970003009 dimer interface [polypeptide binding]; other site 1114970003010 conserved gate region; other site 1114970003011 putative PBP binding loops; other site 1114970003012 ABC-ATPase subunit interface; other site 1114970003013 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1114970003014 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1114970003015 peptide binding site [polypeptide binding]; other site 1114970003016 outer membrane porin, OprD family; Region: OprD; pfam03573 1114970003017 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1114970003018 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1114970003019 peptide binding site [polypeptide binding]; other site 1114970003020 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1114970003021 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1114970003022 peptide binding site [polypeptide binding]; other site 1114970003023 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1114970003024 Protein of unknown function (DUF541); Region: SIMPL; cl01077 1114970003025 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114970003026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970003027 ATP binding site [chemical binding]; other site 1114970003028 G-X-G motif; other site 1114970003029 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 1114970003030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970003031 active site 1114970003032 phosphorylation site [posttranslational modification] 1114970003033 intermolecular recognition site; other site 1114970003034 dimerization interface [polypeptide binding]; other site 1114970003035 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1114970003036 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1114970003037 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1114970003038 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1114970003039 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1114970003040 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970003041 DNA-binding site [nucleotide binding]; DNA binding site 1114970003042 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1114970003043 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 1114970003044 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1114970003045 putative active site [active] 1114970003046 catalytic residue [active] 1114970003047 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 1114970003048 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970003049 NAD(P) binding site [chemical binding]; other site 1114970003050 catalytic residues [active] 1114970003051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970003052 D-galactonate transporter; Region: 2A0114; TIGR00893 1114970003053 putative substrate translocation pore; other site 1114970003054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970003055 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1114970003056 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1114970003057 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1114970003058 Predicted permeases [General function prediction only]; Region: COG0679 1114970003059 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1114970003060 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 1114970003061 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1114970003062 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1114970003063 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1114970003064 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1114970003065 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1114970003066 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1114970003067 GatB domain; Region: GatB_Yqey; smart00845 1114970003068 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1114970003069 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1114970003070 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1114970003071 rod shape-determining protein MreB; Provisional; Region: PRK13927 1114970003072 MreB and similar proteins; Region: MreB_like; cd10225 1114970003073 nucleotide binding site [chemical binding]; other site 1114970003074 Mg binding site [ion binding]; other site 1114970003075 putative protofilament interaction site [polypeptide binding]; other site 1114970003076 RodZ interaction site [polypeptide binding]; other site 1114970003077 rod shape-determining protein MreC; Provisional; Region: PRK13922 1114970003078 rod shape-determining protein MreC; Region: MreC; pfam04085 1114970003079 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 1114970003080 Maf-like protein; Region: Maf; pfam02545 1114970003081 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1114970003082 active site 1114970003083 dimer interface [polypeptide binding]; other site 1114970003084 ribonuclease G; Provisional; Region: PRK11712 1114970003085 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1114970003086 homodimer interface [polypeptide binding]; other site 1114970003087 oligonucleotide binding site [chemical binding]; other site 1114970003088 TIGR02099 family protein; Region: TIGR02099 1114970003089 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1114970003090 nitrilase; Region: PLN02798 1114970003091 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 1114970003092 putative active site [active] 1114970003093 catalytic triad [active] 1114970003094 dimer interface [polypeptide binding]; other site 1114970003095 protease TldD; Provisional; Region: tldD; PRK10735 1114970003096 hypothetical protein; Provisional; Region: PRK05255 1114970003097 peptidase PmbA; Provisional; Region: PRK11040 1114970003098 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1114970003099 Class II fumarases; Region: Fumarase_classII; cd01362 1114970003100 active site 1114970003101 tetramer interface [polypeptide binding]; other site 1114970003102 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1114970003103 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1114970003104 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1114970003105 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1114970003106 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1114970003107 dimerization domain swap beta strand [polypeptide binding]; other site 1114970003108 regulatory protein interface [polypeptide binding]; other site 1114970003109 active site 1114970003110 regulatory phosphorylation site [posttranslational modification]; other site 1114970003111 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1114970003112 AAA domain; Region: AAA_18; pfam13238 1114970003113 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1114970003114 active site 1114970003115 phosphorylation site [posttranslational modification] 1114970003116 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1114970003117 30S subunit binding site; other site 1114970003118 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1114970003119 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1114970003120 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1114970003121 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1114970003122 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1114970003123 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1114970003124 Walker A/P-loop; other site 1114970003125 ATP binding site [chemical binding]; other site 1114970003126 Q-loop/lid; other site 1114970003127 ABC transporter signature motif; other site 1114970003128 Walker B; other site 1114970003129 D-loop; other site 1114970003130 H-loop/switch region; other site 1114970003131 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1114970003132 OstA-like protein; Region: OstA; pfam03968 1114970003133 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 1114970003134 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1114970003135 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1114970003136 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114970003137 active site 1114970003138 motif I; other site 1114970003139 motif II; other site 1114970003140 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1114970003141 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1114970003142 putative active site [active] 1114970003143 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1114970003144 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 1114970003145 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1114970003146 Walker A/P-loop; other site 1114970003147 ATP binding site [chemical binding]; other site 1114970003148 Q-loop/lid; other site 1114970003149 ABC transporter signature motif; other site 1114970003150 Walker B; other site 1114970003151 D-loop; other site 1114970003152 H-loop/switch region; other site 1114970003153 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1114970003154 Permease; Region: Permease; cl00510 1114970003155 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1114970003156 mce related protein; Region: MCE; pfam02470 1114970003157 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 1114970003158 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1114970003159 anti sigma factor interaction site; other site 1114970003160 regulatory phosphorylation site [posttranslational modification]; other site 1114970003161 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 1114970003162 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1114970003163 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1114970003164 hinge; other site 1114970003165 active site 1114970003166 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1114970003167 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1114970003168 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1114970003169 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1114970003170 NAD binding site [chemical binding]; other site 1114970003171 dimerization interface [polypeptide binding]; other site 1114970003172 product binding site; other site 1114970003173 substrate binding site [chemical binding]; other site 1114970003174 zinc binding site [ion binding]; other site 1114970003175 catalytic residues [active] 1114970003176 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1114970003177 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970003178 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970003179 homodimer interface [polypeptide binding]; other site 1114970003180 catalytic residue [active] 1114970003181 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970003182 dimerization interface [polypeptide binding]; other site 1114970003183 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970003184 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970003185 dimer interface [polypeptide binding]; other site 1114970003186 putative CheW interface [polypeptide binding]; other site 1114970003187 Peptidase family M48; Region: Peptidase_M48; pfam01435 1114970003188 Predicted membrane protein [Function unknown]; Region: COG2119 1114970003189 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1114970003190 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1114970003191 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 1114970003192 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1114970003193 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970003194 S-adenosylmethionine binding site [chemical binding]; other site 1114970003195 glycerate dehydrogenase; Provisional; Region: PRK06487 1114970003196 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 1114970003197 putative ligand binding site [chemical binding]; other site 1114970003198 putative NAD binding site [chemical binding]; other site 1114970003199 catalytic site [active] 1114970003200 LysE type translocator; Region: LysE; cl00565 1114970003201 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1114970003202 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1114970003203 acyl-activating enzyme (AAE) consensus motif; other site 1114970003204 AMP binding site [chemical binding]; other site 1114970003205 active site 1114970003206 CoA binding site [chemical binding]; other site 1114970003207 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1114970003208 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1114970003209 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1114970003210 AAA ATPase domain; Region: AAA_16; pfam13191 1114970003211 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970003212 DNA binding residues [nucleotide binding] 1114970003213 dimerization interface [polypeptide binding]; other site 1114970003214 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1114970003215 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1114970003216 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1114970003217 DNA binding site [nucleotide binding] 1114970003218 active site 1114970003219 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1114970003220 metal binding site [ion binding]; metal-binding site 1114970003221 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1114970003222 putative active site [active] 1114970003223 putative metal binding site [ion binding]; other site 1114970003224 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1114970003225 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1114970003226 DctM-like transporters; Region: DctM; pfam06808 1114970003227 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1114970003228 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1114970003229 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1114970003230 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1114970003231 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 1114970003232 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1114970003233 pentamer interface [polypeptide binding]; other site 1114970003234 dodecaamer interface [polypeptide binding]; other site 1114970003235 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 1114970003236 dimer interface [polypeptide binding]; other site 1114970003237 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114970003238 metal binding site [ion binding]; metal-binding site 1114970003239 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177 1114970003240 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 1114970003241 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 1114970003242 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1114970003243 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970003244 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970003245 active site 1114970003246 phosphorylation site [posttranslational modification] 1114970003247 intermolecular recognition site; other site 1114970003248 dimerization interface [polypeptide binding]; other site 1114970003249 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114970003250 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970003251 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1114970003252 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1114970003253 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114970003254 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970003255 dimer interface [polypeptide binding]; other site 1114970003256 phosphorylation site [posttranslational modification] 1114970003257 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970003258 ATP binding site [chemical binding]; other site 1114970003259 Mg2+ binding site [ion binding]; other site 1114970003260 G-X-G motif; other site 1114970003261 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970003262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970003263 active site 1114970003264 phosphorylation site [posttranslational modification] 1114970003265 intermolecular recognition site; other site 1114970003266 dimerization interface [polypeptide binding]; other site 1114970003267 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1114970003268 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970003269 N-terminal plug; other site 1114970003270 ligand-binding site [chemical binding]; other site 1114970003271 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970003272 PAS domain; Region: PAS_9; pfam13426 1114970003273 putative active site [active] 1114970003274 heme pocket [chemical binding]; other site 1114970003275 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114970003276 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970003277 metal binding site [ion binding]; metal-binding site 1114970003278 active site 1114970003279 I-site; other site 1114970003280 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; pfam07073 1114970003281 S-type Pyocin; Region: Pyocin_S; pfam06958 1114970003282 Cytotoxic; Region: Cytotoxic; pfam09000 1114970003283 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970003284 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114970003285 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1114970003286 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1114970003287 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1114970003288 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1114970003289 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1114970003290 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1114970003291 TIR domain; Region: TIR_2; pfam13676 1114970003292 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077 1114970003293 RES domain; Region: RES; pfam08808 1114970003294 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1114970003295 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1114970003296 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1114970003297 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1114970003298 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1114970003299 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1114970003300 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1114970003301 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1114970003302 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1114970003303 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1114970003304 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1114970003305 Protein export membrane protein; Region: SecD_SecF; pfam02355 1114970003306 hypothetical protein; Provisional; Region: PRK11280 1114970003307 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1114970003308 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1114970003309 active site 1114970003310 dimerization interface [polypeptide binding]; other site 1114970003311 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1114970003312 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1114970003313 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1114970003314 serine O-acetyltransferase; Region: cysE; TIGR01172 1114970003315 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1114970003316 trimer interface [polypeptide binding]; other site 1114970003317 active site 1114970003318 substrate binding site [chemical binding]; other site 1114970003319 CoA binding site [chemical binding]; other site 1114970003320 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 1114970003321 Rrf2 family protein; Region: rrf2_super; TIGR00738 1114970003322 cysteine desulfurase; Provisional; Region: PRK14012 1114970003323 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1114970003324 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114970003325 catalytic residue [active] 1114970003326 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1114970003327 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1114970003328 trimerization site [polypeptide binding]; other site 1114970003329 active site 1114970003330 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1114970003331 co-chaperone HscB; Provisional; Region: hscB; PRK00294 1114970003332 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1114970003333 HSP70 interaction site [polypeptide binding]; other site 1114970003334 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 1114970003335 chaperone protein HscA; Provisional; Region: hscA; PRK05183 1114970003336 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 1114970003337 nucleotide binding site [chemical binding]; other site 1114970003338 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1114970003339 SBD interface [polypeptide binding]; other site 1114970003340 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1114970003341 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1114970003342 catalytic loop [active] 1114970003343 iron binding site [ion binding]; other site 1114970003344 FeS assembly protein IscX; Region: iscX_yfhJ; TIGR03412 1114970003345 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1114970003346 active site 1114970003347 multimer interface [polypeptide binding]; other site 1114970003348 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1114970003349 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114970003350 FeS/SAM binding site; other site 1114970003351 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 1114970003352 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114970003353 binding surface 1114970003354 TPR motif; other site 1114970003355 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114970003356 binding surface 1114970003357 TPR motif; other site 1114970003358 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1114970003359 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114970003360 non-specific DNA binding site [nucleotide binding]; other site 1114970003361 salt bridge; other site 1114970003362 sequence-specific DNA binding site [nucleotide binding]; other site 1114970003363 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1114970003364 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1114970003365 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1114970003366 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1114970003367 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1114970003368 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1114970003369 dimer interface [polypeptide binding]; other site 1114970003370 motif 1; other site 1114970003371 active site 1114970003372 motif 2; other site 1114970003373 motif 3; other site 1114970003374 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1114970003375 anticodon binding site; other site 1114970003376 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1114970003377 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 1114970003378 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 1114970003379 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 1114970003380 Trp docking motif [polypeptide binding]; other site 1114970003381 GTP-binding protein Der; Reviewed; Region: PRK00093 1114970003382 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1114970003383 G1 box; other site 1114970003384 GTP/Mg2+ binding site [chemical binding]; other site 1114970003385 Switch I region; other site 1114970003386 G2 box; other site 1114970003387 Switch II region; other site 1114970003388 G3 box; other site 1114970003389 G4 box; other site 1114970003390 G5 box; other site 1114970003391 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1114970003392 G1 box; other site 1114970003393 GTP/Mg2+ binding site [chemical binding]; other site 1114970003394 Switch I region; other site 1114970003395 G2 box; other site 1114970003396 G3 box; other site 1114970003397 Switch II region; other site 1114970003398 G4 box; other site 1114970003399 G5 box; other site 1114970003400 methionine aminotransferase; Validated; Region: PRK09082 1114970003401 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970003402 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970003403 homodimer interface [polypeptide binding]; other site 1114970003404 catalytic residue [active] 1114970003405 C-N hydrolase family amidase; Provisional; Region: PRK10438 1114970003406 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 1114970003407 putative active site [active] 1114970003408 catalytic triad [active] 1114970003409 dimer interface [polypeptide binding]; other site 1114970003410 multimer interface [polypeptide binding]; other site 1114970003411 2-isopropylmalate synthase; Validated; Region: PRK03739 1114970003412 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1114970003413 active site 1114970003414 catalytic residues [active] 1114970003415 metal binding site [ion binding]; metal-binding site 1114970003416 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1114970003417 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1114970003418 Peptidase family M23; Region: Peptidase_M23; pfam01551 1114970003419 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1114970003420 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1114970003421 generic binding surface II; other site 1114970003422 generic binding surface I; other site 1114970003423 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1114970003424 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1114970003425 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1114970003426 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1114970003427 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1114970003428 active site 1114970003429 GMP synthase; Reviewed; Region: guaA; PRK00074 1114970003430 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1114970003431 AMP/PPi binding site [chemical binding]; other site 1114970003432 candidate oxyanion hole; other site 1114970003433 catalytic triad [active] 1114970003434 potential glutamine specificity residues [chemical binding]; other site 1114970003435 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1114970003436 ATP Binding subdomain [chemical binding]; other site 1114970003437 Ligand Binding sites [chemical binding]; other site 1114970003438 Dimerization subdomain; other site 1114970003439 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1114970003440 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970003441 DNA-binding site [nucleotide binding]; DNA binding site 1114970003442 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1114970003443 UTRA domain; Region: UTRA; pfam07702 1114970003444 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1114970003445 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1114970003446 active site turn [active] 1114970003447 phosphorylation site [posttranslational modification] 1114970003448 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1114970003449 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1114970003450 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1114970003451 Ca binding site [ion binding]; other site 1114970003452 active site 1114970003453 catalytic site [active] 1114970003454 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1114970003455 trimer interface; other site 1114970003456 sugar binding site [chemical binding]; other site 1114970003457 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1114970003458 HPr interaction site; other site 1114970003459 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1114970003460 active site 1114970003461 phosphorylation site [posttranslational modification] 1114970003462 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1114970003463 dimerization domain swap beta strand [polypeptide binding]; other site 1114970003464 regulatory protein interface [polypeptide binding]; other site 1114970003465 active site 1114970003466 regulatory phosphorylation site [posttranslational modification]; other site 1114970003467 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1114970003468 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1114970003469 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1114970003470 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1114970003471 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 1114970003472 active site turn [active] 1114970003473 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1114970003474 TPR motif; other site 1114970003475 binding surface 1114970003476 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1114970003477 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1114970003478 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1114970003479 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1114970003480 nucleoside/Zn binding site; other site 1114970003481 dimer interface [polypeptide binding]; other site 1114970003482 catalytic motif [active] 1114970003483 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1114970003484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970003485 S-adenosylmethionine binding site [chemical binding]; other site 1114970003486 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970003487 S-adenosylmethionine binding site [chemical binding]; other site 1114970003488 YhhN-like protein; Region: YhhN; pfam07947 1114970003489 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 1114970003490 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1114970003491 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970003492 Walker A motif; other site 1114970003493 ATP binding site [chemical binding]; other site 1114970003494 Walker B motif; other site 1114970003495 arginine finger; other site 1114970003496 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1114970003497 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970003498 metabolite-proton symporter; Region: 2A0106; TIGR00883 1114970003499 putative substrate translocation pore; other site 1114970003500 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 1114970003501 Domain of unknown function DUF21; Region: DUF21; pfam01595 1114970003502 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1114970003503 Transporter associated domain; Region: CorC_HlyC; smart01091 1114970003504 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 1114970003505 signal recognition particle protein; Provisional; Region: PRK10867 1114970003506 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1114970003507 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1114970003508 P loop; other site 1114970003509 GTP binding site [chemical binding]; other site 1114970003510 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1114970003511 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1114970003512 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1114970003513 RimM N-terminal domain; Region: RimM; pfam01782 1114970003514 PRC-barrel domain; Region: PRC; pfam05239 1114970003515 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1114970003516 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1114970003517 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1114970003518 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1114970003519 active site 1114970003520 Int/Topo IB signature motif; other site 1114970003521 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1114970003522 dimerization domain [polypeptide binding]; other site 1114970003523 dimer interface [polypeptide binding]; other site 1114970003524 catalytic residues [active] 1114970003525 homoserine dehydrogenase; Provisional; Region: PRK06349 1114970003526 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1114970003527 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1114970003528 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1114970003529 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1114970003530 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1114970003531 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970003532 catalytic residue [active] 1114970003533 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970003534 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970003535 substrate binding pocket [chemical binding]; other site 1114970003536 membrane-bound complex binding site; other site 1114970003537 hinge residues; other site 1114970003538 PAS fold; Region: PAS; pfam00989 1114970003539 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970003540 putative active site [active] 1114970003541 heme pocket [chemical binding]; other site 1114970003542 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 1114970003543 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1114970003544 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1114970003545 YaeQ protein; Region: YaeQ; pfam07152 1114970003546 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1114970003547 DHH family; Region: DHH; pfam01368 1114970003548 DHHA1 domain; Region: DHHA1; pfam02272 1114970003549 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1114970003550 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1114970003551 active site 1114970003552 FMN binding site [chemical binding]; other site 1114970003553 substrate binding site [chemical binding]; other site 1114970003554 homotetramer interface [polypeptide binding]; other site 1114970003555 catalytic residue [active] 1114970003556 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 1114970003557 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 1114970003558 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1114970003559 Predicted transcriptional regulator [Transcription]; Region: COG3905 1114970003560 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1114970003561 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1114970003562 tetrameric interface [polypeptide binding]; other site 1114970003563 NAD binding site [chemical binding]; other site 1114970003564 catalytic residues [active] 1114970003565 substrate binding site [chemical binding]; other site 1114970003566 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1114970003567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970003568 dimer interface [polypeptide binding]; other site 1114970003569 conserved gate region; other site 1114970003570 ABC-ATPase subunit interface; other site 1114970003571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970003572 conserved gate region; other site 1114970003573 dimer interface [polypeptide binding]; other site 1114970003574 putative PBP binding loops; other site 1114970003575 ABC-ATPase subunit interface; other site 1114970003576 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1114970003577 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114970003578 Walker A/P-loop; other site 1114970003579 ATP binding site [chemical binding]; other site 1114970003580 Q-loop/lid; other site 1114970003581 ABC transporter signature motif; other site 1114970003582 Walker B; other site 1114970003583 D-loop; other site 1114970003584 H-loop/switch region; other site 1114970003585 TOBE domain; Region: TOBE_2; pfam08402 1114970003586 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1114970003587 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1114970003588 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1114970003589 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1114970003590 tetrameric interface [polypeptide binding]; other site 1114970003591 NAD binding site [chemical binding]; other site 1114970003592 catalytic residues [active] 1114970003593 substrate binding site [chemical binding]; other site 1114970003594 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970003595 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970003596 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 1114970003597 putative substrate binding pocket [chemical binding]; other site 1114970003598 dimerization interface [polypeptide binding]; other site 1114970003599 Protein of unknown function (DUF533); Region: DUF533; pfam04391 1114970003600 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1114970003601 putative metal binding site [ion binding]; other site 1114970003602 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1114970003603 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970003604 dimerization interface [polypeptide binding]; other site 1114970003605 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970003606 dimer interface [polypeptide binding]; other site 1114970003607 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1114970003608 putative CheW interface [polypeptide binding]; other site 1114970003609 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1114970003610 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1114970003611 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970003612 S-adenosylmethionine binding site [chemical binding]; other site 1114970003613 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1114970003614 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1114970003615 putative binding surface; other site 1114970003616 active site 1114970003617 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1114970003618 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970003619 ATP binding site [chemical binding]; other site 1114970003620 Mg2+ binding site [ion binding]; other site 1114970003621 G-X-G motif; other site 1114970003622 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1114970003623 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970003624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970003625 active site 1114970003626 phosphorylation site [posttranslational modification] 1114970003627 intermolecular recognition site; other site 1114970003628 dimerization interface [polypeptide binding]; other site 1114970003629 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 1114970003630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970003631 active site 1114970003632 phosphorylation site [posttranslational modification] 1114970003633 intermolecular recognition site; other site 1114970003634 CheB methylesterase; Region: CheB_methylest; pfam01339 1114970003635 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970003636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970003637 active site 1114970003638 phosphorylation site [posttranslational modification] 1114970003639 intermolecular recognition site; other site 1114970003640 dimerization interface [polypeptide binding]; other site 1114970003641 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114970003642 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970003643 metal binding site [ion binding]; metal-binding site 1114970003644 active site 1114970003645 I-site; other site 1114970003646 peptide chain release factor 2; Provisional; Region: PRK08787 1114970003647 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1114970003648 RF-1 domain; Region: RF-1; pfam00472 1114970003649 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1114970003650 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1114970003651 dimer interface [polypeptide binding]; other site 1114970003652 putative anticodon binding site; other site 1114970003653 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1114970003654 motif 1; other site 1114970003655 active site 1114970003656 motif 2; other site 1114970003657 motif 3; other site 1114970003658 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1114970003659 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 1114970003660 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1114970003661 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114970003662 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1114970003663 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1114970003664 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1114970003665 ligand binding site [chemical binding]; other site 1114970003666 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 1114970003667 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1114970003668 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1114970003669 adenylate kinase; Reviewed; Region: adk; PRK00279 1114970003670 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1114970003671 AMP-binding site [chemical binding]; other site 1114970003672 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1114970003673 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1114970003674 Glycoprotease family; Region: Peptidase_M22; pfam00814 1114970003675 Protein of unknown function DUF72; Region: DUF72; cl00777 1114970003676 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1114970003677 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1114970003678 tetramer interface [polypeptide binding]; other site 1114970003679 active site 1114970003680 Mg2+/Mn2+ binding site [ion binding]; other site 1114970003681 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 1114970003682 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 1114970003683 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970003684 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114970003685 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1114970003686 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1114970003687 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1114970003688 HlyD family secretion protein; Region: HlyD_3; pfam13437 1114970003689 putative membrane fusion protein; Region: TIGR02828 1114970003690 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1114970003691 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 1114970003692 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 1114970003693 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 1114970003694 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1114970003695 putative acyl-acceptor binding pocket; other site 1114970003696 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1114970003697 DNA-binding site [nucleotide binding]; DNA binding site 1114970003698 RNA-binding motif; other site 1114970003699 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1114970003700 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970003701 S-adenosylmethionine binding site [chemical binding]; other site 1114970003702 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1114970003703 active site 1114970003704 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1114970003705 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1114970003706 metal binding site [ion binding]; metal-binding site 1114970003707 dimer interface [polypeptide binding]; other site 1114970003708 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1114970003709 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1114970003710 putative ATP binding site [chemical binding]; other site 1114970003711 putative substrate interface [chemical binding]; other site 1114970003712 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 1114970003713 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1114970003714 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1114970003715 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114970003716 catalytic residue [active] 1114970003717 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536 1114970003718 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1114970003719 putative trimer interface [polypeptide binding]; other site 1114970003720 putative CoA binding site [chemical binding]; other site 1114970003721 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1114970003722 ArsC family; Region: ArsC; pfam03960 1114970003723 putative catalytic residues [active] 1114970003724 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1114970003725 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1114970003726 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 1114970003727 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970003728 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970003729 homodimer interface [polypeptide binding]; other site 1114970003730 catalytic residue [active] 1114970003731 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 1114970003732 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1114970003733 metal binding triad; other site 1114970003734 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1114970003735 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1114970003736 Zn2+ binding site [ion binding]; other site 1114970003737 Mg2+ binding site [ion binding]; other site 1114970003738 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1114970003739 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1114970003740 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1114970003741 active site 1114970003742 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1114970003743 rRNA interaction site [nucleotide binding]; other site 1114970003744 S8 interaction site; other site 1114970003745 putative laminin-1 binding site; other site 1114970003746 elongation factor Ts; Provisional; Region: tsf; PRK09377 1114970003747 UBA/TS-N domain; Region: UBA; pfam00627 1114970003748 Elongation factor TS; Region: EF_TS; pfam00889 1114970003749 Elongation factor TS; Region: EF_TS; pfam00889 1114970003750 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1114970003751 putative nucleotide binding site [chemical binding]; other site 1114970003752 uridine monophosphate binding site [chemical binding]; other site 1114970003753 homohexameric interface [polypeptide binding]; other site 1114970003754 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1114970003755 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1114970003756 hinge region; other site 1114970003757 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1114970003758 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1114970003759 catalytic residue [active] 1114970003760 putative FPP diphosphate binding site; other site 1114970003761 putative FPP binding hydrophobic cleft; other site 1114970003762 dimer interface [polypeptide binding]; other site 1114970003763 putative IPP diphosphate binding site; other site 1114970003764 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 1114970003765 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1114970003766 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1114970003767 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1114970003768 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1114970003769 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1114970003770 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1114970003771 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1114970003772 active site 1114970003773 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1114970003774 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1114970003775 protein binding site [polypeptide binding]; other site 1114970003776 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1114970003777 putative substrate binding region [chemical binding]; other site 1114970003778 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1114970003779 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1114970003780 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1114970003781 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1114970003782 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1114970003783 Surface antigen; Region: Bac_surface_Ag; pfam01103 1114970003784 periplasmic chaperone; Provisional; Region: PRK10780 1114970003785 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1114970003786 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1114970003787 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1114970003788 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1114970003789 trimer interface [polypeptide binding]; other site 1114970003790 active site 1114970003791 UDP-GlcNAc binding site [chemical binding]; other site 1114970003792 lipid binding site [chemical binding]; lipid-binding site 1114970003793 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1114970003794 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1114970003795 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1114970003796 active site 1114970003797 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1114970003798 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1114970003799 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1114970003800 RNA/DNA hybrid binding site [nucleotide binding]; other site 1114970003801 active site 1114970003802 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1114970003803 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1114970003804 putative active site [active] 1114970003805 putative PHP Thumb interface [polypeptide binding]; other site 1114970003806 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1114970003807 generic binding surface II; other site 1114970003808 generic binding surface I; other site 1114970003809 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1114970003810 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1114970003811 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 1114970003812 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1114970003813 Ligand Binding Site [chemical binding]; other site 1114970003814 TilS substrate binding domain; Region: TilS; pfam09179 1114970003815 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 1114970003816 CTP synthetase; Validated; Region: pyrG; PRK05380 1114970003817 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1114970003818 Catalytic site [active] 1114970003819 active site 1114970003820 UTP binding site [chemical binding]; other site 1114970003821 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1114970003822 active site 1114970003823 putative oxyanion hole; other site 1114970003824 catalytic triad [active] 1114970003825 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1114970003826 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1114970003827 enolase; Provisional; Region: eno; PRK00077 1114970003828 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1114970003829 dimer interface [polypeptide binding]; other site 1114970003830 metal binding site [ion binding]; metal-binding site 1114970003831 substrate binding pocket [chemical binding]; other site 1114970003832 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1114970003833 Septum formation initiator; Region: DivIC; cl17659 1114970003834 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1114970003835 substrate binding site; other site 1114970003836 dimer interface; other site 1114970003837 LysR family transcriptional regulator; Provisional; Region: PRK14997 1114970003838 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970003839 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like_1; cd08470 1114970003840 putative effector binding pocket; other site 1114970003841 putative dimerization interface [polypeptide binding]; other site 1114970003842 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1114970003843 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1114970003844 substrate binding site [chemical binding]; other site 1114970003845 catalytic Zn binding site [ion binding]; other site 1114970003846 NAD binding site [chemical binding]; other site 1114970003847 structural Zn binding site [ion binding]; other site 1114970003848 dimer interface [polypeptide binding]; other site 1114970003849 S-formylglutathione hydrolase; Region: PLN02442 1114970003850 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1114970003851 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1114970003852 homotrimer interaction site [polypeptide binding]; other site 1114970003853 zinc binding site [ion binding]; other site 1114970003854 CDP-binding sites; other site 1114970003855 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 1114970003856 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 1114970003857 Permutation of conserved domain; other site 1114970003858 active site 1114970003859 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1114970003860 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1114970003861 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1114970003862 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970003863 S-adenosylmethionine binding site [chemical binding]; other site 1114970003864 Peptidase family M23; Region: Peptidase_M23; pfam01551 1114970003865 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 1114970003866 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1114970003867 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970003868 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1114970003869 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114970003870 DNA binding residues [nucleotide binding] 1114970003871 Helix-turn-helix domain; Region: HTH_28; pfam13518 1114970003872 putative transposase OrfB; Reviewed; Region: PHA02517 1114970003873 Homeodomain-like domain; Region: HTH_32; pfam13565 1114970003874 Integrase core domain; Region: rve; pfam00665 1114970003875 Integrase core domain; Region: rve_3; pfam13683 1114970003876 Ferredoxin [Energy production and conversion]; Region: COG1146 1114970003877 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 1114970003878 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1114970003879 MutS domain I; Region: MutS_I; pfam01624 1114970003880 MutS domain II; Region: MutS_II; pfam05188 1114970003881 MutS domain III; Region: MutS_III; pfam05192 1114970003882 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1114970003883 Walker A/P-loop; other site 1114970003884 ATP binding site [chemical binding]; other site 1114970003885 Q-loop/lid; other site 1114970003886 ABC transporter signature motif; other site 1114970003887 Walker B; other site 1114970003888 D-loop; other site 1114970003889 H-loop/switch region; other site 1114970003890 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1114970003891 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114970003892 non-specific DNA binding site [nucleotide binding]; other site 1114970003893 salt bridge; other site 1114970003894 sequence-specific DNA binding site [nucleotide binding]; other site 1114970003895 Predicted transcriptional regulator [Transcription]; Region: COG2932 1114970003896 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1114970003897 Catalytic site [active] 1114970003898 choice-of-anchor C domain; Region: choice_anch_C; TIGR04362 1114970003899 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1114970003900 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1114970003901 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1114970003902 Baseplate J-like protein; Region: Baseplate_J; cl01294 1114970003903 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684 1114970003904 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 1114970003905 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1114970003906 Phage tail tube protein FII; Region: Phage_tube; cl01390 1114970003907 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1114970003908 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1114970003909 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1114970003910 Phage P2 GpU; Region: Phage_P2_GpU; cl01391 1114970003911 Phage Tail Protein X; Region: Phage_tail_X; cl02088 1114970003912 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1114970003913 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 1114970003914 Predicted chitinase [General function prediction only]; Region: COG3179 1114970003915 catalytic residue [active] 1114970003916 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 1114970003917 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1114970003918 recombinase A; Provisional; Region: recA; PRK09354 1114970003919 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1114970003920 hexamer interface [polypeptide binding]; other site 1114970003921 Walker A motif; other site 1114970003922 ATP binding site [chemical binding]; other site 1114970003923 Walker B motif; other site 1114970003924 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1114970003925 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1114970003926 Domain of unknown function (DUF4146); Region: DUF4146; pfam13652 1114970003927 Uncharacterized conserved protein [Function unknown]; Region: COG3148 1114970003928 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114970003929 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970003930 active site 1114970003931 phosphorylation site [posttranslational modification] 1114970003932 intermolecular recognition site; other site 1114970003933 dimerization interface [polypeptide binding]; other site 1114970003934 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970003935 DNA binding residues [nucleotide binding] 1114970003936 dimerization interface [polypeptide binding]; other site 1114970003937 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1114970003938 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970003939 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1114970003940 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1114970003941 putative dimerization interface [polypeptide binding]; other site 1114970003942 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1114970003943 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1114970003944 FAD binding pocket [chemical binding]; other site 1114970003945 FAD binding motif [chemical binding]; other site 1114970003946 phosphate binding motif [ion binding]; other site 1114970003947 beta-alpha-beta structure motif; other site 1114970003948 NAD binding pocket [chemical binding]; other site 1114970003949 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1114970003950 homodimer interaction site [polypeptide binding]; other site 1114970003951 cofactor binding site; other site 1114970003952 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 1114970003953 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1114970003954 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1114970003955 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1114970003956 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1114970003957 RNA binding surface [nucleotide binding]; other site 1114970003958 Pseudouridine synthase, a subgroup of the RsuA family; Region: PSSA_1; cd02555 1114970003959 active site 1114970003960 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1114970003961 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970003962 Coenzyme A binding pocket [chemical binding]; other site 1114970003963 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1114970003964 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1114970003965 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114970003966 FeS/SAM binding site; other site 1114970003967 TRAM domain; Region: TRAM; cl01282 1114970003968 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 1114970003969 potassium uptake protein; Region: kup; TIGR00794 1114970003970 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 1114970003971 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 1114970003972 Predicted integral membrane protein [Function unknown]; Region: COG0392 1114970003973 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1114970003974 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1114970003975 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1114970003976 active site 1114970003977 DNA polymerase IV; Validated; Region: PRK02406 1114970003978 DNA binding site [nucleotide binding] 1114970003979 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1114970003980 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1114970003981 dimer interface [polypeptide binding]; other site 1114970003982 motif 1; other site 1114970003983 active site 1114970003984 motif 2; other site 1114970003985 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1114970003986 putative deacylase active site [active] 1114970003987 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1114970003988 active site 1114970003989 motif 3; other site 1114970003990 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1114970003991 anticodon binding site; other site 1114970003992 muropeptide transporter; Validated; Region: ampG; cl17669 1114970003993 muropeptide transporter; Validated; Region: ampG; cl17669 1114970003994 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1114970003995 active site 1114970003996 DNA binding site [nucleotide binding] 1114970003997 Protein of unknown function, DUF481; Region: DUF481; pfam04338 1114970003998 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1114970003999 DNA-binding site [nucleotide binding]; DNA binding site 1114970004000 RNA-binding motif; other site 1114970004001 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1114970004002 trimer interface [polypeptide binding]; other site 1114970004003 active site 1114970004004 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1114970004005 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1114970004006 Walker A/P-loop; other site 1114970004007 ATP binding site [chemical binding]; other site 1114970004008 Q-loop/lid; other site 1114970004009 ABC transporter signature motif; other site 1114970004010 Walker B; other site 1114970004011 D-loop; other site 1114970004012 H-loop/switch region; other site 1114970004013 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 1114970004014 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1114970004015 active site 1114970004016 Zn binding site [ion binding]; other site 1114970004017 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114970004018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970004019 dimer interface [polypeptide binding]; other site 1114970004020 conserved gate region; other site 1114970004021 putative PBP binding loops; other site 1114970004022 ABC-ATPase subunit interface; other site 1114970004023 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114970004024 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970004025 dimer interface [polypeptide binding]; other site 1114970004026 conserved gate region; other site 1114970004027 putative PBP binding loops; other site 1114970004028 ABC-ATPase subunit interface; other site 1114970004029 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1114970004030 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970004031 substrate binding pocket [chemical binding]; other site 1114970004032 membrane-bound complex binding site; other site 1114970004033 hinge residues; other site 1114970004034 ATP-dependent DNA ligase; Validated; Region: PRK09247 1114970004035 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 1114970004036 active site 1114970004037 DNA binding site [nucleotide binding] 1114970004038 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 1114970004039 DNA binding site [nucleotide binding] 1114970004040 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 1114970004041 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1114970004042 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 1114970004043 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 1114970004044 active site 1114970004045 Isochorismatase family; Region: Isochorismatase; pfam00857 1114970004046 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1114970004047 catalytic triad [active] 1114970004048 conserved cis-peptide bond; other site 1114970004049 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 1114970004050 hypothetical protein; Provisional; Region: PRK00183 1114970004051 SEC-C motif; Region: SEC-C; pfam02810 1114970004052 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1114970004053 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1114970004054 ligand binding site [chemical binding]; other site 1114970004055 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1114970004056 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1114970004057 ligand binding site [chemical binding]; other site 1114970004058 Predicted integral membrane protein [Function unknown]; Region: COG5615 1114970004059 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 1114970004060 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1114970004061 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1114970004062 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1114970004063 Beta-lactamase; Region: Beta-lactamase; pfam00144 1114970004064 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1114970004065 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1114970004066 ligand binding site [chemical binding]; other site 1114970004067 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1114970004068 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1114970004069 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1114970004070 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 1114970004071 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 1114970004072 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1114970004073 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1114970004074 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114970004075 catalytic residue [active] 1114970004076 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 1114970004077 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1114970004078 Predicted membrane protein [Function unknown]; Region: COG3650 1114970004079 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 1114970004080 putative NAD(P) binding site [chemical binding]; other site 1114970004081 homodimer interface [polypeptide binding]; other site 1114970004082 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970004083 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970004084 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1114970004085 putative effector binding pocket; other site 1114970004086 dimerization interface [polypeptide binding]; other site 1114970004087 Predicted membrane protein [Function unknown]; Region: COG2259 1114970004088 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 1114970004089 hypothetical protein; Provisional; Region: PRK05409 1114970004090 Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048 1114970004091 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1114970004092 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1114970004093 Walker A/P-loop; other site 1114970004094 ATP binding site [chemical binding]; other site 1114970004095 Q-loop/lid; other site 1114970004096 ABC transporter signature motif; other site 1114970004097 Walker B; other site 1114970004098 D-loop; other site 1114970004099 H-loop/switch region; other site 1114970004100 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1114970004101 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1114970004102 Walker A/P-loop; other site 1114970004103 ATP binding site [chemical binding]; other site 1114970004104 Q-loop/lid; other site 1114970004105 ABC transporter signature motif; other site 1114970004106 Walker B; other site 1114970004107 D-loop; other site 1114970004108 H-loop/switch region; other site 1114970004109 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1114970004110 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1114970004111 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1114970004112 TM-ABC transporter signature motif; other site 1114970004113 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1114970004114 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1114970004115 TM-ABC transporter signature motif; other site 1114970004116 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1114970004117 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1114970004118 dimerization interface [polypeptide binding]; other site 1114970004119 ligand binding site [chemical binding]; other site 1114970004120 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 1114970004121 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970004122 putative substrate translocation pore; other site 1114970004123 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970004124 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970004125 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970004126 putative substrate translocation pore; other site 1114970004127 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970004128 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 1114970004129 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1114970004130 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1114970004131 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1114970004132 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1114970004133 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970004134 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1114970004135 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1114970004136 putative substrate binding site [chemical binding]; other site 1114970004137 nucleotide binding site [chemical binding]; other site 1114970004138 nucleotide binding site [chemical binding]; other site 1114970004139 homodimer interface [polypeptide binding]; other site 1114970004140 ornithine carbamoyltransferase; Validated; Region: PRK02102 1114970004141 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1114970004142 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1114970004143 arginine deiminase; Provisional; Region: PRK01388 1114970004144 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1114970004145 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1114970004146 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1114970004147 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1114970004148 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 1114970004149 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1114970004150 heme binding pocket [chemical binding]; other site 1114970004151 heme ligand [chemical binding]; other site 1114970004152 Secretin and TonB N terminus short domain; Region: STN; smart00965 1114970004153 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1114970004154 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970004155 N-terminal plug; other site 1114970004156 ligand-binding site [chemical binding]; other site 1114970004157 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1114970004158 FecR protein; Region: FecR; pfam04773 1114970004159 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1114970004160 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970004161 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114970004162 DNA binding residues [nucleotide binding] 1114970004163 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1114970004164 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1114970004165 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1114970004166 phosphogluconate dehydratase; Validated; Region: PRK09054 1114970004167 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1114970004168 glucokinase; Provisional; Region: glk; PRK00292 1114970004169 glucokinase, proteobacterial type; Region: glk; TIGR00749 1114970004170 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114970004171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970004172 active site 1114970004173 phosphorylation site [posttranslational modification] 1114970004174 intermolecular recognition site; other site 1114970004175 dimerization interface [polypeptide binding]; other site 1114970004176 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970004177 DNA binding site [nucleotide binding] 1114970004178 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 1114970004179 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970004180 ATP binding site [chemical binding]; other site 1114970004181 Mg2+ binding site [ion binding]; other site 1114970004182 G-X-G motif; other site 1114970004183 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 1114970004184 putative active cleft [active] 1114970004185 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1114970004186 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1114970004187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970004188 dimer interface [polypeptide binding]; other site 1114970004189 conserved gate region; other site 1114970004190 putative PBP binding loops; other site 1114970004191 ABC-ATPase subunit interface; other site 1114970004192 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1114970004193 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970004194 dimer interface [polypeptide binding]; other site 1114970004195 conserved gate region; other site 1114970004196 putative PBP binding loops; other site 1114970004197 ABC-ATPase subunit interface; other site 1114970004198 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1114970004199 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1114970004200 Walker A/P-loop; other site 1114970004201 ATP binding site [chemical binding]; other site 1114970004202 Q-loop/lid; other site 1114970004203 ABC transporter signature motif; other site 1114970004204 Walker B; other site 1114970004205 D-loop; other site 1114970004206 H-loop/switch region; other site 1114970004207 TOBE domain; Region: TOBE; pfam03459 1114970004208 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 1114970004209 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1114970004210 active site 1114970004211 phosphate binding residues; other site 1114970004212 catalytic residues [active] 1114970004213 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1114970004214 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1114970004215 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1114970004216 putative active site [active] 1114970004217 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1114970004218 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1114970004219 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1114970004220 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1114970004221 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1114970004222 putative active site [active] 1114970004223 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1114970004224 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1114970004225 active site 1114970004226 intersubunit interface [polypeptide binding]; other site 1114970004227 catalytic residue [active] 1114970004228 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1114970004229 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1114970004230 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114970004231 catalytic residue [active] 1114970004232 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 1114970004233 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 1114970004234 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1114970004235 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1114970004236 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 1114970004237 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1114970004238 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1114970004239 HlyD family secretion protein; Region: HlyD_3; pfam13437 1114970004240 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 1114970004241 dimer interaction site [polypeptide binding]; other site 1114970004242 substrate-binding tunnel; other site 1114970004243 active site 1114970004244 catalytic site [active] 1114970004245 substrate binding site [chemical binding]; other site 1114970004246 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1114970004247 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1114970004248 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1114970004249 long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12492 1114970004250 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1114970004251 acyl-activating enzyme (AAE) consensus motif; other site 1114970004252 putative AMP binding site [chemical binding]; other site 1114970004253 putative active site [active] 1114970004254 putative CoA binding site [chemical binding]; other site 1114970004255 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677 1114970004256 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1114970004257 acyl-activating enzyme (AAE) consensus motif; other site 1114970004258 putative active site [active] 1114970004259 putative AMP binding site [chemical binding]; other site 1114970004260 putative CoA binding site [chemical binding]; other site 1114970004261 MAC/Perforin domain; Region: MACPF; cl02616 1114970004262 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1114970004263 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1114970004264 active site 1114970004265 catalytic residues [active] 1114970004266 metal binding site [ion binding]; metal-binding site 1114970004267 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970004268 Coenzyme A binding pocket [chemical binding]; other site 1114970004269 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114970004270 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114970004271 DNA binding site [nucleotide binding] 1114970004272 domain linker motif; other site 1114970004273 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1114970004274 putative ligand binding site [chemical binding]; other site 1114970004275 putative dimerization interface [polypeptide binding]; other site 1114970004276 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1114970004277 AAA domain; Region: AAA_33; pfam13671 1114970004278 ATP-binding site [chemical binding]; other site 1114970004279 Gluconate-6-phosphate binding site [chemical binding]; other site 1114970004280 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1114970004281 GntP family permease; Region: GntP_permease; pfam02447 1114970004282 aminotransferase; Validated; Region: PRK08175 1114970004283 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970004284 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970004285 homodimer interface [polypeptide binding]; other site 1114970004286 catalytic residue [active] 1114970004287 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1114970004288 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1114970004289 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 1114970004290 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970004291 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1114970004292 Coenzyme A binding pocket [chemical binding]; other site 1114970004293 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1114970004294 SnoaL-like domain; Region: SnoaL_3; pfam13474 1114970004295 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1114970004296 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1114970004297 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1114970004298 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970004299 Imelysin; Region: Peptidase_M75; cl09159 1114970004300 biofilm formation regulator HmsP; Provisional; Region: PRK11829 1114970004301 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970004302 metal binding site [ion binding]; metal-binding site 1114970004303 active site 1114970004304 I-site; other site 1114970004305 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970004306 superoxide dismutase; Provisional; Region: PRK10543 1114970004307 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1114970004308 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1114970004309 Lysine efflux permease [General function prediction only]; Region: COG1279 1114970004310 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1114970004311 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970004312 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970004313 dimerization interface [polypeptide binding]; other site 1114970004314 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1114970004315 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970004316 NAD(P) binding site [chemical binding]; other site 1114970004317 active site 1114970004318 Cache domain; Region: Cache_2; cl07034 1114970004319 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1114970004320 ATP-dependent helicase HepA; Validated; Region: PRK04914 1114970004321 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114970004322 ATP binding site [chemical binding]; other site 1114970004323 putative Mg++ binding site [ion binding]; other site 1114970004324 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114970004325 nucleotide binding region [chemical binding]; other site 1114970004326 ATP-binding site [chemical binding]; other site 1114970004327 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1114970004328 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1114970004329 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1114970004330 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1114970004331 Bacterial transcriptional regulator; Region: IclR; pfam01614 1114970004332 benzoate transport; Region: 2A0115; TIGR00895 1114970004333 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970004334 putative substrate translocation pore; other site 1114970004335 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970004336 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1114970004337 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 1114970004338 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1114970004339 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1114970004340 dimer interface [polypeptide binding]; other site 1114970004341 active site 1114970004342 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 1114970004343 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 1114970004344 heterodimer interface [polypeptide binding]; other site 1114970004345 multimer interface [polypeptide binding]; other site 1114970004346 active site 1114970004347 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 1114970004348 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 1114970004349 heterodimer interface [polypeptide binding]; other site 1114970004350 active site 1114970004351 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1114970004352 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970004353 putative substrate translocation pore; other site 1114970004354 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 1114970004355 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 1114970004356 tetramer interface [polypeptide binding]; other site 1114970004357 active site 1114970004358 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1114970004359 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 1114970004360 outer membrane porin, OprD family; Region: OprD; pfam03573 1114970004361 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1114970004362 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1114970004363 Protein export membrane protein; Region: SecD_SecF; cl14618 1114970004364 Protein export membrane protein; Region: SecD_SecF; cl14618 1114970004365 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1114970004366 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1114970004367 HlyD family secretion protein; Region: HlyD_3; pfam13437 1114970004368 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 1114970004369 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114970004370 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1114970004371 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1114970004372 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1114970004373 FMN binding site [chemical binding]; other site 1114970004374 active site 1114970004375 substrate binding site [chemical binding]; other site 1114970004376 catalytic residue [active] 1114970004377 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1114970004378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970004379 putative substrate translocation pore; other site 1114970004380 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114970004381 dimerization interface [polypeptide binding]; other site 1114970004382 putative DNA binding site [nucleotide binding]; other site 1114970004383 putative Zn2+ binding site [ion binding]; other site 1114970004384 Protein of unknown function, DUF479; Region: DUF479; cl01203 1114970004385 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1114970004386 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1114970004387 putative acyl-acceptor binding pocket; other site 1114970004388 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1114970004389 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1114970004390 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1114970004391 Beta-lactamase; Region: Beta-lactamase; pfam00144 1114970004392 YceI-like domain; Region: YceI; pfam04264 1114970004393 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1114970004394 PLD-like domain; Region: PLDc_2; pfam13091 1114970004395 putative active site [active] 1114970004396 catalytic site [active] 1114970004397 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1114970004398 PLD-like domain; Region: PLDc_2; pfam13091 1114970004399 putative active site [active] 1114970004400 catalytic site [active] 1114970004401 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1114970004402 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1114970004403 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1114970004404 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1114970004405 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1114970004406 Repair protein; Region: Repair_PSII; pfam04536 1114970004407 Repair protein; Region: Repair_PSII; cl01535 1114970004408 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1114970004409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970004410 S-adenosylmethionine binding site [chemical binding]; other site 1114970004411 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1114970004412 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 1114970004413 conserved cys residue [active] 1114970004414 Uncharacterized conserved protein [Function unknown]; Region: COG3422 1114970004415 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 1114970004416 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1114970004417 putative alcohol dehydrogenase; Provisional; Region: PRK09860 1114970004418 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1114970004419 dimer interface [polypeptide binding]; other site 1114970004420 active site 1114970004421 metal binding site [ion binding]; metal-binding site 1114970004422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970004423 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1114970004424 putative substrate translocation pore; other site 1114970004425 hypothetical protein; Provisional; Region: PRK07505 1114970004426 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1114970004427 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114970004428 catalytic residue [active] 1114970004429 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 1114970004430 FosA, a Fosfomycin resistance protein, catalyzes the addition of glutathione to the antibiotic fosfomycin, making it inactive; Region: FosA; cd07244 1114970004431 dimer interface [polypeptide binding]; other site 1114970004432 Mn binding site [ion binding]; other site 1114970004433 K binding site [ion binding]; other site 1114970004434 PAS fold; Region: PAS; pfam00989 1114970004435 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970004436 putative active site [active] 1114970004437 heme pocket [chemical binding]; other site 1114970004438 GAF domain; Region: GAF_3; pfam13492 1114970004439 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1114970004440 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114970004441 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970004442 metal binding site [ion binding]; metal-binding site 1114970004443 active site 1114970004444 I-site; other site 1114970004445 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 1114970004446 Low affinity iron permease; Region: Iron_permease; pfam04120 1114970004447 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1114970004448 YcfA-like protein; Region: YcfA; pfam07927 1114970004449 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1114970004450 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1114970004451 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114970004452 putative DNA binding site [nucleotide binding]; other site 1114970004453 putative Zn2+ binding site [ion binding]; other site 1114970004454 AsnC family; Region: AsnC_trans_reg; pfam01037 1114970004455 Protein of unknown function (DUF3077); Region: DUF3077; pfam11275 1114970004456 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1114970004457 AAA domain; Region: AAA_33; pfam13671 1114970004458 Walker A motif; other site 1114970004459 ATP binding site [chemical binding]; other site 1114970004460 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114970004461 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 1114970004462 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1114970004463 active site 1114970004464 uracil binding [chemical binding]; other site 1114970004465 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 1114970004466 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114970004467 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970004468 metal binding site [ion binding]; metal-binding site 1114970004469 active site 1114970004470 I-site; other site 1114970004471 allophanate hydrolase; Provisional; Region: PRK08186 1114970004472 Amidase; Region: Amidase; cl11426 1114970004473 urea carboxylase; Region: urea_carbox; TIGR02712 1114970004474 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1114970004475 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1114970004476 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1114970004477 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1114970004478 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1114970004479 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1114970004480 carboxyltransferase (CT) interaction site; other site 1114970004481 biotinylation site [posttranslational modification]; other site 1114970004482 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1114970004483 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 1114970004484 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1114970004485 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 1114970004486 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1114970004487 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1114970004488 Walker A/P-loop; other site 1114970004489 ATP binding site [chemical binding]; other site 1114970004490 Q-loop/lid; other site 1114970004491 ABC transporter signature motif; other site 1114970004492 Walker B; other site 1114970004493 D-loop; other site 1114970004494 H-loop/switch region; other site 1114970004495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1114970004496 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 1114970004497 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1114970004498 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1114970004499 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114970004500 substrate binding site [chemical binding]; other site 1114970004501 oxyanion hole (OAH) forming residues; other site 1114970004502 trimer interface [polypeptide binding]; other site 1114970004503 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1114970004504 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1114970004505 ligand binding site [chemical binding]; other site 1114970004506 active site 1114970004507 UGI interface [polypeptide binding]; other site 1114970004508 catalytic site [active] 1114970004509 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1114970004510 Putative ammonia monooxygenase; Region: AmoA; pfam05145 1114970004511 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1114970004512 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1114970004513 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1114970004514 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1114970004515 outer membrane porin, OprD family; Region: OprD; pfam03573 1114970004516 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 1114970004517 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970004518 active site 1114970004519 phosphorylation site [posttranslational modification] 1114970004520 intermolecular recognition site; other site 1114970004521 dimerization interface [polypeptide binding]; other site 1114970004522 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970004523 DNA binding site [nucleotide binding] 1114970004524 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 1114970004525 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114970004526 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1114970004527 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970004528 dimer interface [polypeptide binding]; other site 1114970004529 phosphorylation site [posttranslational modification] 1114970004530 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970004531 ATP binding site [chemical binding]; other site 1114970004532 Mg2+ binding site [ion binding]; other site 1114970004533 G-X-G motif; other site 1114970004534 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 1114970004535 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1114970004536 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1114970004537 Uncharacterized conserved protein [Function unknown]; Region: COG2938 1114970004538 L-aspartate oxidase; Provisional; Region: PRK09077 1114970004539 L-aspartate oxidase; Provisional; Region: PRK06175 1114970004540 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1114970004541 RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923 1114970004542 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970004543 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114970004544 DNA binding residues [nucleotide binding] 1114970004545 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073 1114970004546 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 1114970004547 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 1114970004548 anti-sigma E factor; Provisional; Region: rseB; PRK09455 1114970004549 MucB/RseB family; Region: MucB_RseB; pfam03888 1114970004550 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1114970004551 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1114970004552 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1114970004553 protein binding site [polypeptide binding]; other site 1114970004554 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1114970004555 protein binding site [polypeptide binding]; other site 1114970004556 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1114970004557 Peptidase family M48; Region: Peptidase_M48; cl12018 1114970004558 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1114970004559 binding surface 1114970004560 TPR motif; other site 1114970004561 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1114970004562 CPxP motif; other site 1114970004563 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1114970004564 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1114970004565 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1114970004566 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1114970004567 catalytic triad [active] 1114970004568 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 1114970004569 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1114970004570 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 1114970004571 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1114970004572 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1114970004573 dimer interface [polypeptide binding]; other site 1114970004574 active site 1114970004575 catalytic residue [active] 1114970004576 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 1114970004577 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 1114970004578 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1114970004579 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1114970004580 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1114970004581 ATP binding site [chemical binding]; other site 1114970004582 active site 1114970004583 substrate binding site [chemical binding]; other site 1114970004584 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 1114970004585 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 1114970004586 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 1114970004587 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1114970004588 MULE transposase domain; Region: MULE; pfam10551 1114970004589 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1114970004590 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970004591 dimerization interface [polypeptide binding]; other site 1114970004592 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1114970004593 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970004594 dimer interface [polypeptide binding]; other site 1114970004595 putative CheW interface [polypeptide binding]; other site 1114970004596 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1114970004597 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1114970004598 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1114970004599 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114970004600 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970004601 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 1114970004602 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970004603 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970004604 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 1114970004605 putative substrate binding pocket [chemical binding]; other site 1114970004606 putative dimerization interface [polypeptide binding]; other site 1114970004607 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 1114970004608 putative substrate binding pocket [chemical binding]; other site 1114970004609 trimer interface [polypeptide binding]; other site 1114970004610 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970004611 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970004612 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1114970004613 substrate binding pocket [chemical binding]; other site 1114970004614 dimerization interface [polypeptide binding]; other site 1114970004615 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1114970004616 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1114970004617 putative metal dependent hydrolase; Provisional; Region: PRK11598 1114970004618 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1114970004619 Sulfatase; Region: Sulfatase; pfam00884 1114970004620 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1114970004621 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970004622 S-adenosylmethionine binding site [chemical binding]; other site 1114970004623 ribonuclease D; Region: rnd; TIGR01388 1114970004624 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1114970004625 catalytic site [active] 1114970004626 putative active site [active] 1114970004627 putative substrate binding site [chemical binding]; other site 1114970004628 HRDC domain; Region: HRDC; pfam00570 1114970004629 YcgL domain; Region: YcgL; pfam05166 1114970004630 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 1114970004631 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1114970004632 NAD binding site [chemical binding]; other site 1114970004633 ligand binding site [chemical binding]; other site 1114970004634 catalytic site [active] 1114970004635 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 1114970004636 putative FMN binding site [chemical binding]; other site 1114970004637 hypothetical protein; Provisional; Region: PRK05170 1114970004638 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1114970004639 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1114970004640 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1114970004641 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1114970004642 active site 1114970004643 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1114970004644 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1114970004645 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1114970004646 ligand binding site [chemical binding]; other site 1114970004647 flexible hinge region; other site 1114970004648 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1114970004649 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1114970004650 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1114970004651 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1114970004652 putative active site [active] 1114970004653 putative dimer interface [polypeptide binding]; other site 1114970004654 Protein of unknown function (DUF2937); Region: DUF2937; pfam11157 1114970004655 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 1114970004656 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1114970004657 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970004658 Walker A motif; other site 1114970004659 ATP binding site [chemical binding]; other site 1114970004660 Walker B motif; other site 1114970004661 arginine finger; other site 1114970004662 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 1114970004663 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 1114970004664 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1114970004665 salt bridge; other site 1114970004666 non-specific DNA binding site [nucleotide binding]; other site 1114970004667 sequence-specific DNA binding site [nucleotide binding]; other site 1114970004668 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1114970004669 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1114970004670 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1114970004671 dimer interface [polypeptide binding]; other site 1114970004672 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970004673 catalytic residue [active] 1114970004674 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 1114970004675 EamA-like transporter family; Region: EamA; pfam00892 1114970004676 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1114970004677 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 1114970004678 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 1114970004679 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 1114970004680 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114970004681 ATP binding site [chemical binding]; other site 1114970004682 putative Mg++ binding site [ion binding]; other site 1114970004683 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114970004684 nucleotide binding region [chemical binding]; other site 1114970004685 ATP-binding site [chemical binding]; other site 1114970004686 Helicase associated domain (HA2); Region: HA2; pfam04408 1114970004687 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1114970004688 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1114970004689 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 1114970004690 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1114970004691 dimer interface [polypeptide binding]; other site 1114970004692 active site 1114970004693 CoA binding pocket [chemical binding]; other site 1114970004694 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1114970004695 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970004696 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114970004697 DNA binding residues [nucleotide binding] 1114970004698 Putative zinc-finger; Region: zf-HC2; pfam13490 1114970004699 Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746 1114970004700 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 1114970004701 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 1114970004702 Protein of unknown function, DUF482; Region: DUF482; pfam04339 1114970004703 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1114970004704 amphipathic channel; other site 1114970004705 Asn-Pro-Ala signature motifs; other site 1114970004706 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1114970004707 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1114970004708 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1114970004709 Walker A/P-loop; other site 1114970004710 ATP binding site [chemical binding]; other site 1114970004711 Q-loop/lid; other site 1114970004712 ABC transporter signature motif; other site 1114970004713 Walker B; other site 1114970004714 D-loop; other site 1114970004715 H-loop/switch region; other site 1114970004716 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 1114970004717 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1114970004718 substrate binding site [chemical binding]; other site 1114970004719 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1114970004720 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1114970004721 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1114970004722 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970004723 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970004724 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1114970004725 dimerization interface [polypeptide binding]; other site 1114970004726 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 1114970004727 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1114970004728 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114970004729 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970004730 dimer interface [polypeptide binding]; other site 1114970004731 phosphorylation site [posttranslational modification] 1114970004732 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970004733 ATP binding site [chemical binding]; other site 1114970004734 Mg2+ binding site [ion binding]; other site 1114970004735 G-X-G motif; other site 1114970004736 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970004737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970004738 active site 1114970004739 phosphorylation site [posttranslational modification] 1114970004740 intermolecular recognition site; other site 1114970004741 dimerization interface [polypeptide binding]; other site 1114970004742 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1114970004743 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1114970004744 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1114970004745 helicase 45; Provisional; Region: PTZ00424 1114970004746 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1114970004747 ATP binding site [chemical binding]; other site 1114970004748 Mg++ binding site [ion binding]; other site 1114970004749 motif III; other site 1114970004750 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114970004751 nucleotide binding region [chemical binding]; other site 1114970004752 ATP-binding site [chemical binding]; other site 1114970004753 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1114970004754 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1114970004755 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1114970004756 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1114970004757 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1114970004758 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1114970004759 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 1114970004760 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 1114970004761 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 1114970004762 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 1114970004763 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1114970004764 S1 domain; Region: S1_2; pfam13509 1114970004765 S1 domain; Region: S1_2; pfam13509 1114970004766 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 1114970004767 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1114970004768 Na binding site [ion binding]; other site 1114970004769 putative substrate binding site [chemical binding]; other site 1114970004770 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 1114970004771 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970004772 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970004773 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1114970004774 putative dimerization interface [polypeptide binding]; other site 1114970004775 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 1114970004776 Na binding site [ion binding]; other site 1114970004777 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 1114970004778 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1114970004779 Na binding site [ion binding]; other site 1114970004780 SnoaL-like domain; Region: SnoaL_3; pfam13474 1114970004781 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1114970004782 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1114970004783 agmatinase; Region: agmatinase; TIGR01230 1114970004784 oligomer interface [polypeptide binding]; other site 1114970004785 putative active site [active] 1114970004786 Mn binding site [ion binding]; other site 1114970004787 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970004788 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970004789 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1114970004790 dimerization interface [polypeptide binding]; other site 1114970004791 DTW domain; Region: DTW; cl01221 1114970004792 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1114970004793 HlyD family secretion protein; Region: HlyD_3; pfam13437 1114970004794 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 1114970004795 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 1114970004796 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1114970004797 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114970004798 Walker A/P-loop; other site 1114970004799 ATP binding site [chemical binding]; other site 1114970004800 Q-loop/lid; other site 1114970004801 ABC transporter signature motif; other site 1114970004802 Walker B; other site 1114970004803 D-loop; other site 1114970004804 H-loop/switch region; other site 1114970004805 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1114970004806 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 1114970004807 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 1114970004808 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1114970004809 metal ion-dependent adhesion site (MIDAS); other site 1114970004810 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 1114970004811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 1114970004812 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 1114970004813 yecA family protein; Region: ygfB_yecA; TIGR02292 1114970004814 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1114970004815 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114970004816 ATP binding site [chemical binding]; other site 1114970004817 putative Mg++ binding site [ion binding]; other site 1114970004818 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114970004819 nucleotide binding region [chemical binding]; other site 1114970004820 ATP-binding site [chemical binding]; other site 1114970004821 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1114970004822 HRDC domain; Region: HRDC; pfam00570 1114970004823 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114970004824 MarR family; Region: MarR_2; pfam12802 1114970004825 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114970004826 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 1114970004827 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1114970004828 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 1114970004829 active site 1114970004830 nucleophile elbow; other site 1114970004831 Surface antigen; Region: Bac_surface_Ag; pfam01103 1114970004832 Uncharacterized protein conserved in bacteria [Posttranslational modification, protein turnover, chaperones]; Region: COG3526 1114970004833 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1114970004834 EamA-like transporter family; Region: EamA; pfam00892 1114970004835 Cupin domain; Region: Cupin_2; cl17218 1114970004836 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114970004837 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970004838 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1114970004839 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1114970004840 putative active site [active] 1114970004841 putative metal binding site [ion binding]; other site 1114970004842 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564 1114970004843 Protein of unknown function (DUF962); Region: DUF962; pfam06127 1114970004844 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1114970004845 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114970004846 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970004847 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1114970004848 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1114970004849 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1114970004850 putative FMN binding site [chemical binding]; other site 1114970004851 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1114970004852 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970004853 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970004854 homodimer interface [polypeptide binding]; other site 1114970004855 catalytic residue [active] 1114970004856 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 1114970004857 aromatic arch; other site 1114970004858 DCoH dimer interaction site [polypeptide binding]; other site 1114970004859 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1114970004860 DCoH tetramer interaction site [polypeptide binding]; other site 1114970004861 substrate binding site [chemical binding]; other site 1114970004862 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 1114970004863 cofactor binding site; other site 1114970004864 metal binding site [ion binding]; metal-binding site 1114970004865 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 1114970004866 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1114970004867 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970004868 putative active site [active] 1114970004869 heme pocket [chemical binding]; other site 1114970004870 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970004871 Walker A motif; other site 1114970004872 ATP binding site [chemical binding]; other site 1114970004873 Walker B motif; other site 1114970004874 arginine finger; other site 1114970004875 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 1114970004876 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1114970004877 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1114970004878 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1114970004879 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1114970004880 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1114970004881 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 1114970004882 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 1114970004883 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1114970004884 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1114970004885 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 1114970004886 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 1114970004887 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1114970004888 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK05683 1114970004889 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1114970004890 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1114970004891 flagellar hook-associated protein FlgL; Provisional; Region: flgL; PRK12717 1114970004892 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1114970004893 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1114970004894 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1114970004895 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1114970004896 active site 1114970004897 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1114970004898 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1114970004899 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1114970004900 active site 1114970004901 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114970004902 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 1114970004903 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1114970004904 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1114970004905 substrate binding site; other site 1114970004906 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 1114970004907 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 1114970004908 NAD binding site [chemical binding]; other site 1114970004909 homotetramer interface [polypeptide binding]; other site 1114970004910 homodimer interface [polypeptide binding]; other site 1114970004911 substrate binding site [chemical binding]; other site 1114970004912 active site 1114970004913 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1114970004914 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970004915 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1114970004916 NAD(P) binding site [chemical binding]; other site 1114970004917 active site 1114970004918 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1114970004919 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970004920 S-adenosylmethionine binding site [chemical binding]; other site 1114970004921 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 1114970004922 Cephalosporin hydroxylase; Region: CmcI; pfam04989 1114970004923 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1114970004924 active site 1114970004925 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1114970004926 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1114970004927 active site 1114970004928 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 1114970004929 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1114970004930 NAD(P) binding site [chemical binding]; other site 1114970004931 homodimer interface [polypeptide binding]; other site 1114970004932 substrate binding site [chemical binding]; other site 1114970004933 active site 1114970004934 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1114970004935 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1114970004936 inhibitor-cofactor binding pocket; inhibition site 1114970004937 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970004938 catalytic residue [active] 1114970004939 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 1114970004940 ligand binding site; other site 1114970004941 tetramer interface; other site 1114970004942 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 1114970004943 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1114970004944 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1114970004945 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1114970004946 pseudaminic acid synthase; Region: PseI; TIGR03586 1114970004947 NeuB family; Region: NeuB; pfam03102 1114970004948 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1114970004949 NeuB binding interface [polypeptide binding]; other site 1114970004950 putative substrate binding site [chemical binding]; other site 1114970004951 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1114970004952 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 1114970004953 dimer interface [polypeptide binding]; other site 1114970004954 active site 1114970004955 CoA binding pocket [chemical binding]; other site 1114970004956 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 1114970004957 flagellin; Provisional; Region: PRK12802 1114970004958 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1114970004959 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1114970004960 FlaG protein; Region: FlaG; pfam03646 1114970004961 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 1114970004962 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1114970004963 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1114970004964 flagellar protein FliS; Validated; Region: fliS; PRK05685 1114970004965 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1114970004966 Flagellar regulatory protein FleQ; Region: FleQ; pfam06490 1114970004967 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970004968 Walker A motif; other site 1114970004969 ATP binding site [chemical binding]; other site 1114970004970 Walker B motif; other site 1114970004971 arginine finger; other site 1114970004972 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1114970004973 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1114970004974 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970004975 dimer interface [polypeptide binding]; other site 1114970004976 phosphorylation site [posttranslational modification] 1114970004977 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970004978 ATP binding site [chemical binding]; other site 1114970004979 Mg2+ binding site [ion binding]; other site 1114970004980 G-X-G motif; other site 1114970004981 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1114970004982 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970004983 active site 1114970004984 phosphorylation site [posttranslational modification] 1114970004985 intermolecular recognition site; other site 1114970004986 dimerization interface [polypeptide binding]; other site 1114970004987 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970004988 Walker A motif; other site 1114970004989 ATP binding site [chemical binding]; other site 1114970004990 Walker B motif; other site 1114970004991 arginine finger; other site 1114970004992 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1114970004993 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 1114970004994 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1114970004995 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1114970004996 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1114970004997 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1114970004998 MgtE intracellular N domain; Region: MgtE_N; cl15244 1114970004999 FliG C-terminal domain; Region: FliG_C; pfam01706 1114970005000 flagellar assembly protein H; Validated; Region: fliH; PRK05687 1114970005001 Flagellar assembly protein FliH; Region: FliH; pfam02108 1114970005002 flagellum-specific ATP synthase; Validated; Region: fliI; PRK05688 1114970005003 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1114970005004 Walker A motif/ATP binding site; other site 1114970005005 Walker B motif; other site 1114970005006 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 1114970005007 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 1114970005008 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1114970005009 anti sigma factor interaction site; other site 1114970005010 regulatory phosphorylation site [posttranslational modification]; other site 1114970005011 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1114970005012 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970005013 active site 1114970005014 phosphorylation site [posttranslational modification] 1114970005015 intermolecular recognition site; other site 1114970005016 dimerization interface [polypeptide binding]; other site 1114970005017 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1114970005018 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1114970005019 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970005020 ATP binding site [chemical binding]; other site 1114970005021 Mg2+ binding site [ion binding]; other site 1114970005022 G-X-G motif; other site 1114970005023 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1114970005024 putative binding surface; other site 1114970005025 active site 1114970005026 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1114970005027 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK05696 1114970005028 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1114970005029 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1114970005030 flagellar motor switch protein; Validated; Region: fliN; PRK05698 1114970005031 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1114970005032 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 1114970005033 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1114970005034 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1114970005035 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1114970005036 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1114970005037 CcmE; Region: CcmE; cl00994 1114970005038 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1114970005039 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1114970005040 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1114970005041 active site 1114970005042 catalytic site [active] 1114970005043 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1114970005044 FHIPEP family; Region: FHIPEP; pfam00771 1114970005045 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 1114970005046 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1114970005047 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1114970005048 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1114970005049 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1114970005050 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 1114970005051 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970005052 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1114970005053 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114970005054 DNA binding residues [nucleotide binding] 1114970005055 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1114970005056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970005057 active site 1114970005058 phosphorylation site [posttranslational modification] 1114970005059 intermolecular recognition site; other site 1114970005060 dimerization interface [polypeptide binding]; other site 1114970005061 Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344 1114970005062 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1114970005063 putative binding surface; other site 1114970005064 active site 1114970005065 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1114970005066 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1114970005067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970005068 ATP binding site [chemical binding]; other site 1114970005069 Mg2+ binding site [ion binding]; other site 1114970005070 G-X-G motif; other site 1114970005071 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1114970005072 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970005073 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970005074 active site 1114970005075 phosphorylation site [posttranslational modification] 1114970005076 intermolecular recognition site; other site 1114970005077 dimerization interface [polypeptide binding]; other site 1114970005078 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1114970005079 CheB methylesterase; Region: CheB_methylest; pfam01339 1114970005080 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1114970005081 flagellar motor protein; Reviewed; Region: motC; PRK09109 1114970005082 flagellar motor protein MotD; Reviewed; Region: PRK09038 1114970005083 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1114970005084 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1114970005085 ligand binding site [chemical binding]; other site 1114970005086 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1114970005087 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1114970005088 P-loop; other site 1114970005089 Magnesium ion binding site [ion binding]; other site 1114970005090 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1114970005091 Magnesium ion binding site [ion binding]; other site 1114970005092 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 1114970005093 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1114970005094 putative CheA interaction surface; other site 1114970005095 Protein of unknown function (DUF2802); Region: DUF2802; pfam10975 1114970005096 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1114970005097 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1114970005098 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 1114970005099 AAA domain; Region: AAA_23; pfam13476 1114970005100 Walker A/P-loop; other site 1114970005101 ATP binding site [chemical binding]; other site 1114970005102 ABC transporter; Region: ABC_tran; pfam00005 1114970005103 Q-loop/lid; other site 1114970005104 ABC transporter signature motif; other site 1114970005105 Walker B; other site 1114970005106 D-loop; other site 1114970005107 H-loop/switch region; other site 1114970005108 CcmB protein; Region: CcmB; pfam03379 1114970005109 heme exporter protein CcmC; Region: ccmC; TIGR01191 1114970005110 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 1114970005111 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 1114970005112 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 1114970005113 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1114970005114 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1114970005115 catalytic residues [active] 1114970005116 central insert; other site 1114970005117 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 1114970005118 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 1114970005119 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 1114970005120 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114970005121 binding surface 1114970005122 TPR motif; other site 1114970005123 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1114970005124 Sulfatase; Region: Sulfatase; pfam00884 1114970005125 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 1114970005126 short chain dehydrogenase; Provisional; Region: PRK05650 1114970005127 classical (c) SDRs; Region: SDR_c; cd05233 1114970005128 NAD(P) binding site [chemical binding]; other site 1114970005129 active site 1114970005130 hypothetical protein; Provisional; Region: PRK02237 1114970005131 Global regulator protein family; Region: CsrA; pfam02599 1114970005132 hypothetical protein; Provisional; Region: PRK00304 1114970005133 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1114970005134 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1114970005135 putative oligomer interface [polypeptide binding]; other site 1114970005136 putative active site [active] 1114970005137 metal binding site [ion binding]; metal-binding site 1114970005138 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 1114970005139 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970005140 Coenzyme A binding pocket [chemical binding]; other site 1114970005141 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1114970005142 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 1114970005143 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1114970005144 active site 1114970005145 dimer interface [polypeptide binding]; other site 1114970005146 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1114970005147 Ligand Binding Site [chemical binding]; other site 1114970005148 Molecular Tunnel; other site 1114970005149 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 1114970005150 Uncharacterized conserved protein [Function unknown]; Region: COG4121 1114970005151 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 1114970005152 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1114970005153 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1114970005154 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 1114970005155 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1114970005156 dimer interface [polypeptide binding]; other site 1114970005157 active site 1114970005158 EamA-like transporter family; Region: EamA; pfam00892 1114970005159 fumarate hydratase; Provisional; Region: PRK12425 1114970005160 Class II fumarases; Region: Fumarase_classII; cd01362 1114970005161 active site 1114970005162 tetramer interface [polypeptide binding]; other site 1114970005163 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 1114970005164 BolA-like protein; Region: BolA; pfam01722 1114970005165 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 1114970005166 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1114970005167 active site residue [active] 1114970005168 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 1114970005169 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1114970005170 catalytic residues [active] 1114970005171 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1114970005172 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1114970005173 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114970005174 Walker A/P-loop; other site 1114970005175 ATP binding site [chemical binding]; other site 1114970005176 Q-loop/lid; other site 1114970005177 ABC transporter signature motif; other site 1114970005178 Walker B; other site 1114970005179 D-loop; other site 1114970005180 H-loop/switch region; other site 1114970005181 PAS domain S-box; Region: sensory_box; TIGR00229 1114970005182 PAS domain; Region: PAS; smart00091 1114970005183 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114970005184 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970005185 metal binding site [ion binding]; metal-binding site 1114970005186 active site 1114970005187 I-site; other site 1114970005188 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970005189 Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424 1114970005190 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114970005191 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970005192 metal binding site [ion binding]; metal-binding site 1114970005193 active site 1114970005194 I-site; other site 1114970005195 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 1114970005196 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970005197 NAD(P) binding site [chemical binding]; other site 1114970005198 active site 1114970005199 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1114970005200 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114970005201 motif II; other site 1114970005202 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1114970005203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970005204 S-adenosylmethionine binding site [chemical binding]; other site 1114970005205 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 1114970005206 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1114970005207 active site 1114970005208 putative substrate binding pocket [chemical binding]; other site 1114970005209 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1114970005210 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1114970005211 DNA gyrase subunit A; Validated; Region: PRK05560 1114970005212 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1114970005213 CAP-like domain; other site 1114970005214 active site 1114970005215 primary dimer interface [polypeptide binding]; other site 1114970005216 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114970005217 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114970005218 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114970005219 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114970005220 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114970005221 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114970005222 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1114970005223 homodimer interface [polypeptide binding]; other site 1114970005224 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970005225 substrate-cofactor binding pocket; other site 1114970005226 catalytic residue [active] 1114970005227 Chorismate mutase type II; Region: CM_2; cl00693 1114970005228 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1114970005229 Prephenate dehydratase; Region: PDT; pfam00800 1114970005230 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1114970005231 putative L-Phe binding site [chemical binding]; other site 1114970005232 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1114970005233 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970005234 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970005235 homodimer interface [polypeptide binding]; other site 1114970005236 catalytic residue [active] 1114970005237 bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK14806 1114970005238 prephenate dehydrogenase; Validated; Region: PRK08507 1114970005239 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1114970005240 hinge; other site 1114970005241 active site 1114970005242 cytidylate kinase; Provisional; Region: cmk; PRK00023 1114970005243 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1114970005244 CMP-binding site; other site 1114970005245 The sites determining sugar specificity; other site 1114970005246 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1114970005247 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1114970005248 RNA binding site [nucleotide binding]; other site 1114970005249 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1114970005250 RNA binding site [nucleotide binding]; other site 1114970005251 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1114970005252 RNA binding site [nucleotide binding]; other site 1114970005253 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1114970005254 RNA binding site [nucleotide binding]; other site 1114970005255 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1114970005256 RNA binding site [nucleotide binding]; other site 1114970005257 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1114970005258 RNA binding site [nucleotide binding]; other site 1114970005259 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1114970005260 IHF dimer interface [polypeptide binding]; other site 1114970005261 IHF - DNA interface [nucleotide binding]; other site 1114970005262 Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765 1114970005263 Chain length determinant protein; Region: Wzz; pfam02706 1114970005264 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1114970005265 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1114970005266 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1114970005267 active site 1114970005268 homodimer interface [polypeptide binding]; other site 1114970005269 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 1114970005270 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1114970005271 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1114970005272 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1114970005273 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1114970005274 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 1114970005275 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1114970005276 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 1114970005277 putative NAD(P) binding site [chemical binding]; other site 1114970005278 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1114970005279 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1114970005280 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1114970005281 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 1114970005282 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114970005283 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1114970005284 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970005285 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 1114970005286 putative catalytic motif [active] 1114970005287 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1114970005288 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1114970005289 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1114970005290 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1114970005291 NAD(P) binding site [chemical binding]; other site 1114970005292 homodimer interface [polypeptide binding]; other site 1114970005293 substrate binding site [chemical binding]; other site 1114970005294 active site 1114970005295 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1114970005296 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1114970005297 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970005298 DNA-binding site [nucleotide binding]; DNA binding site 1114970005299 FCD domain; Region: FCD; pfam07729 1114970005300 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 1114970005301 Protein of unknown function (DUF2897); Region: DUF2897; pfam11446 1114970005302 ethanolamine permease; Region: 2A0305; TIGR00908 1114970005303 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1114970005304 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1114970005305 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1114970005306 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1114970005307 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1114970005308 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 1114970005309 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1114970005310 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1114970005311 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1114970005312 Ligand Binding Site [chemical binding]; other site 1114970005313 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1114970005314 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970005315 dimer interface [polypeptide binding]; other site 1114970005316 phosphorylation site [posttranslational modification] 1114970005317 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970005318 ATP binding site [chemical binding]; other site 1114970005319 Mg2+ binding site [ion binding]; other site 1114970005320 G-X-G motif; other site 1114970005321 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1114970005322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970005323 active site 1114970005324 phosphorylation site [posttranslational modification] 1114970005325 intermolecular recognition site; other site 1114970005326 dimerization interface [polypeptide binding]; other site 1114970005327 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970005328 DNA binding site [nucleotide binding] 1114970005329 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1114970005330 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1114970005331 active site 1114970005332 nucleophile elbow; other site 1114970005333 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 1114970005334 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1114970005335 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1114970005336 active site 1114970005337 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1114970005338 active site 2 [active] 1114970005339 active site 1 [active] 1114970005340 Terminase small subunit; Region: Terminase_2; cl01513 1114970005341 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970005342 dimerization interface [polypeptide binding]; other site 1114970005343 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970005344 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970005345 dimer interface [polypeptide binding]; other site 1114970005346 putative CheW interface [polypeptide binding]; other site 1114970005347 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1114970005348 active site 1114970005349 Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein [Cell envelope biogenesis, outer membrane]; Region: COG4623 1114970005350 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970005351 substrate binding pocket [chemical binding]; other site 1114970005352 membrane-bound complex binding site; other site 1114970005353 hinge residues; other site 1114970005354 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1114970005355 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1114970005356 catalytic residue [active] 1114970005357 Predicted membrane protein [Function unknown]; Region: COG2259 1114970005358 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1114970005359 Reovirus P9-like family; Region: Reo_P9; pfam06043 1114970005360 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1114970005361 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1114970005362 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1114970005363 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1114970005364 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 1114970005365 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1114970005366 Walker A/P-loop; other site 1114970005367 ATP binding site [chemical binding]; other site 1114970005368 Q-loop/lid; other site 1114970005369 ABC transporter signature motif; other site 1114970005370 Walker B; other site 1114970005371 D-loop; other site 1114970005372 H-loop/switch region; other site 1114970005373 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1114970005374 active site 1114970005375 catalytic triad [active] 1114970005376 oxyanion hole [active] 1114970005377 switch loop; other site 1114970005378 L,D-transpeptidase; Provisional; Region: PRK10260 1114970005379 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1114970005380 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970005381 Coenzyme A binding pocket [chemical binding]; other site 1114970005382 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1114970005383 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1114970005384 2-dehydropantoate 2-reductase; Provisional; Region: PRK06249 1114970005385 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1114970005386 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1114970005387 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 1114970005388 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1114970005389 Ligand Binding Site [chemical binding]; other site 1114970005390 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 1114970005391 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970005392 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 1114970005393 substrate binding site [chemical binding]; other site 1114970005394 dimerization interface [polypeptide binding]; other site 1114970005395 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1114970005396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 1114970005397 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 1114970005398 elongation factor P; Validated; Region: PRK00529 1114970005399 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1114970005400 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1114970005401 RNA binding site [nucleotide binding]; other site 1114970005402 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1114970005403 RNA binding site [nucleotide binding]; other site 1114970005404 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1114970005405 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1114970005406 substrate binding pocket [chemical binding]; other site 1114970005407 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1114970005408 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1114970005409 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114970005410 MarR family; Region: MarR; pfam01047 1114970005411 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1114970005412 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970005413 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970005414 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970005415 dimerization interface [polypeptide binding]; other site 1114970005416 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 1114970005417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1114970005418 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1114970005419 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1114970005420 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970005421 helicase 45; Provisional; Region: PTZ00424 1114970005422 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1114970005423 ATP binding site [chemical binding]; other site 1114970005424 Mg++ binding site [ion binding]; other site 1114970005425 motif III; other site 1114970005426 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114970005427 nucleotide binding region [chemical binding]; other site 1114970005428 ATP-binding site [chemical binding]; other site 1114970005429 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1114970005430 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1114970005431 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1114970005432 putative active site [active] 1114970005433 metal binding site [ion binding]; metal-binding site 1114970005434 thiopurine S-methyltransferase; Reviewed; Region: PRK13255 1114970005435 heat shock protein HtpX; Provisional; Region: PRK05457 1114970005436 aminotransferase AlaT; Validated; Region: PRK09265 1114970005437 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970005438 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970005439 homodimer interface [polypeptide binding]; other site 1114970005440 catalytic residue [active] 1114970005441 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1114970005442 SelR domain; Region: SelR; pfam01641 1114970005443 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1114970005444 catalytic residues [active] 1114970005445 dimer interface [polypeptide binding]; other site 1114970005446 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114970005447 MarR family; Region: MarR; pfam01047 1114970005448 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970005449 dimer interface [polypeptide binding]; other site 1114970005450 phosphorylation site [posttranslational modification] 1114970005451 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970005452 ATP binding site [chemical binding]; other site 1114970005453 Mg2+ binding site [ion binding]; other site 1114970005454 G-X-G motif; other site 1114970005455 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1114970005456 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970005457 active site 1114970005458 phosphorylation site [posttranslational modification] 1114970005459 intermolecular recognition site; other site 1114970005460 dimerization interface [polypeptide binding]; other site 1114970005461 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 1114970005462 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970005463 Walker A motif; other site 1114970005464 ATP binding site [chemical binding]; other site 1114970005465 Walker B motif; other site 1114970005466 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1114970005467 GAF domain; Region: GAF_2; pfam13185 1114970005468 HAMP domain; Region: HAMP; pfam00672 1114970005469 GAF domain; Region: GAF_3; pfam13492 1114970005470 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1114970005471 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 1114970005472 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970005473 substrate binding pocket [chemical binding]; other site 1114970005474 membrane-bound complex binding site; other site 1114970005475 hinge residues; other site 1114970005476 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970005477 substrate binding pocket [chemical binding]; other site 1114970005478 membrane-bound complex binding site; other site 1114970005479 hinge residues; other site 1114970005480 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970005481 putative active site [active] 1114970005482 heme pocket [chemical binding]; other site 1114970005483 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970005484 dimer interface [polypeptide binding]; other site 1114970005485 phosphorylation site [posttranslational modification] 1114970005486 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970005487 ATP binding site [chemical binding]; other site 1114970005488 Mg2+ binding site [ion binding]; other site 1114970005489 G-X-G motif; other site 1114970005490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970005491 active site 1114970005492 phosphorylation site [posttranslational modification] 1114970005493 intermolecular recognition site; other site 1114970005494 dimerization interface [polypeptide binding]; other site 1114970005495 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1114970005496 putative binding surface; other site 1114970005497 active site 1114970005498 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114970005499 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970005500 active site 1114970005501 phosphorylation site [posttranslational modification] 1114970005502 intermolecular recognition site; other site 1114970005503 dimerization interface [polypeptide binding]; other site 1114970005504 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970005505 DNA binding residues [nucleotide binding] 1114970005506 dimerization interface [polypeptide binding]; other site 1114970005507 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 1114970005508 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1114970005509 Zn2+ binding site [ion binding]; other site 1114970005510 Mg2+ binding site [ion binding]; other site 1114970005511 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1114970005512 Predicted membrane protein [Function unknown]; Region: COG5393 1114970005513 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 1114970005514 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1114970005515 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1114970005516 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1114970005517 TrkA-N domain; Region: TrkA_N; pfam02254 1114970005518 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1114970005519 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1114970005520 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 1114970005521 probable active site [active] 1114970005522 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1114970005523 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1114970005524 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1114970005525 GTP binding site; other site 1114970005526 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1114970005527 MPT binding site; other site 1114970005528 trimer interface [polypeptide binding]; other site 1114970005529 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1114970005530 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1114970005531 dimer interface [polypeptide binding]; other site 1114970005532 putative functional site; other site 1114970005533 putative MPT binding site; other site 1114970005534 lipid kinase; Reviewed; Region: PRK13054 1114970005535 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1114970005536 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114970005537 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970005538 active site 1114970005539 phosphorylation site [posttranslational modification] 1114970005540 intermolecular recognition site; other site 1114970005541 dimerization interface [polypeptide binding]; other site 1114970005542 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970005543 DNA binding residues [nucleotide binding] 1114970005544 dimerization interface [polypeptide binding]; other site 1114970005545 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1114970005546 Histidine kinase; Region: HisKA_3; pfam07730 1114970005547 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970005548 ATP binding site [chemical binding]; other site 1114970005549 Mg2+ binding site [ion binding]; other site 1114970005550 G-X-G motif; other site 1114970005551 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1114970005552 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1114970005553 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970005554 active site 1114970005555 phosphorylation site [posttranslational modification] 1114970005556 intermolecular recognition site; other site 1114970005557 dimerization interface [polypeptide binding]; other site 1114970005558 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1114970005559 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1114970005560 MOSC domain; Region: MOSC; pfam03473 1114970005561 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 1114970005562 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 1114970005563 active site 1114970005564 catalytic site [active] 1114970005565 substrate binding site [chemical binding]; other site 1114970005566 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1114970005567 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1114970005568 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1114970005569 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1114970005570 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1114970005571 carboxyltransferase (CT) interaction site; other site 1114970005572 biotinylation site [posttranslational modification]; other site 1114970005573 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1114970005574 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1114970005575 active site 1114970005576 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1114970005577 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1114970005578 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1114970005579 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1114970005580 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970005581 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114970005582 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1114970005583 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970005584 substrate binding pocket [chemical binding]; other site 1114970005585 membrane-bound complex binding site; other site 1114970005586 hinge residues; other site 1114970005587 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1114970005588 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1114970005589 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 1114970005590 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970005591 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114970005592 DNA binding residues [nucleotide binding] 1114970005593 peptide synthase; Validated; Region: PRK05691 1114970005594 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1114970005595 acyl-activating enzyme (AAE) consensus motif; other site 1114970005596 active site 1114970005597 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114970005598 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1114970005599 acyl-activating enzyme (AAE) consensus motif; other site 1114970005600 AMP binding site [chemical binding]; other site 1114970005601 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114970005602 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114970005603 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1114970005604 acyl-activating enzyme (AAE) consensus motif; other site 1114970005605 AMP binding site [chemical binding]; other site 1114970005606 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114970005607 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1114970005608 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1114970005609 acyl-activating enzyme (AAE) consensus motif; other site 1114970005610 AMP binding site [chemical binding]; other site 1114970005611 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114970005612 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1114970005613 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 1114970005614 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1114970005615 dimerization domain [polypeptide binding]; other site 1114970005616 dimer interface [polypeptide binding]; other site 1114970005617 catalytic residues [active] 1114970005618 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1114970005619 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1114970005620 catalytic residues [active] 1114970005621 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 1114970005622 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1114970005623 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1114970005624 DsbD alpha interface [polypeptide binding]; other site 1114970005625 catalytic residues [active] 1114970005626 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1114970005627 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970005628 active site 1114970005629 phosphorylation site [posttranslational modification] 1114970005630 intermolecular recognition site; other site 1114970005631 dimerization interface [polypeptide binding]; other site 1114970005632 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970005633 DNA binding site [nucleotide binding] 1114970005634 sensor protein QseC; Provisional; Region: PRK10337 1114970005635 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970005636 dimer interface [polypeptide binding]; other site 1114970005637 phosphorylation site [posttranslational modification] 1114970005638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970005639 ATP binding site [chemical binding]; other site 1114970005640 G-X-G motif; other site 1114970005641 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 1114970005642 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114970005643 inhibitor-cofactor binding pocket; inhibition site 1114970005644 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970005645 catalytic residue [active] 1114970005646 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1114970005647 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970005648 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970005649 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1114970005650 putative effector binding pocket; other site 1114970005651 dimerization interface [polypeptide binding]; other site 1114970005652 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1114970005653 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1114970005654 potential catalytic triad [active] 1114970005655 conserved cys residue [active] 1114970005656 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1114970005657 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1114970005658 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1114970005659 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1114970005660 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1114970005661 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114970005662 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1114970005663 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1114970005664 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 1114970005665 Cl binding site [ion binding]; other site 1114970005666 oligomer interface [polypeptide binding]; other site 1114970005667 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970005668 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114970005669 DNA binding residues [nucleotide binding] 1114970005670 OprF membrane domain; Region: OprF; pfam05736 1114970005671 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1114970005672 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1114970005673 ligand binding site [chemical binding]; other site 1114970005674 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1114970005675 active site 1114970005676 SAM binding site [chemical binding]; other site 1114970005677 homodimer interface [polypeptide binding]; other site 1114970005678 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1114970005679 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1114970005680 [4Fe-4S] binding site [ion binding]; other site 1114970005681 molybdopterin cofactor binding site; other site 1114970005682 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1114970005683 molybdopterin cofactor binding site; other site 1114970005684 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1114970005685 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1114970005686 [2Fe-2S] cluster binding site [ion binding]; other site 1114970005687 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1114970005688 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114970005689 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1114970005690 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1114970005691 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1114970005692 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1114970005693 active site 1114970005694 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1114970005695 active site 1114970005696 ATP binding site [chemical binding]; other site 1114970005697 substrate binding site [chemical binding]; other site 1114970005698 activation loop (A-loop); other site 1114970005699 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1114970005700 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970005701 putative substrate translocation pore; other site 1114970005702 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1114970005703 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970005704 active site 1114970005705 phosphorylation site [posttranslational modification] 1114970005706 intermolecular recognition site; other site 1114970005707 dimerization interface [polypeptide binding]; other site 1114970005708 ANTAR domain; Region: ANTAR; pfam03861 1114970005709 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1114970005710 NMT1-like family; Region: NMT1_2; pfam13379 1114970005711 transcriptional regulator InvF; Provisional; Region: PRK15340 1114970005712 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970005713 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970005714 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 1114970005715 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1114970005716 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1114970005717 type III secretion system regulator InvE; Provisional; Region: PRK15338 1114970005718 HrpJ-like domain; Region: HrpJ; cl15454 1114970005719 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 1114970005720 type III secretion system protein InvA; Provisional; Region: PRK15337 1114970005721 ATP synthase SpaL; Validated; Region: PRK08149 1114970005722 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1114970005723 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1114970005724 Walker A motif; other site 1114970005725 ATP binding site [chemical binding]; other site 1114970005726 Walker B motif; other site 1114970005727 type III secretion system protein SpaO; Validated; Region: PRK08158 1114970005728 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1114970005729 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 1114970005730 type III secretion system protein SpaQ; Provisional; Region: PRK15333 1114970005731 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 1114970005732 type III secretion system protein SpaS; Validated; Region: PRK08156 1114970005733 chaperone protein SicA; Provisional; Region: PRK15331 1114970005734 Tetratricopeptide repeat; Region: TPR_3; pfam07720 1114970005735 pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374 1114970005736 Salmonella-Shigella invasin protein C (IpaC_SipC); Region: IpaC_SipC; cl10712 1114970005737 Invasion plasmid antigen IpaD; Region: IpaD; cl05827 1114970005738 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114970005739 invasion protein regulator; Provisional; Region: PRK12370 1114970005740 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970005741 DNA binding site [nucleotide binding] 1114970005742 Tubulin C-terminal domain; Region: Tubulin_C; cl10021 1114970005743 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1114970005744 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1114970005745 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1114970005746 catalytic residue [active] 1114970005747 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327; cl12363 1114970005748 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 1114970005749 Type III secretion needle MxiH like; Region: MxiH; cl09641 1114970005750 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 1114970005751 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1114970005752 Bacterial type III secretion apparatus protein (OrgA_MxiK); Region: OrgA_MxiK; cl09716 1114970005753 invasion protein OrgA; Provisional; Region: PRK15323 1114970005754 invasion protein OrgB; Provisional; Region: PRK15322 1114970005755 Transposase; Region: HTH_Tnp_1; pfam01527 1114970005756 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1114970005757 Integrase core domain; Region: rve_3; cl15866 1114970005758 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 1114970005759 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 1114970005760 DNA binding residues [nucleotide binding] 1114970005761 dimer interface [polypeptide binding]; other site 1114970005762 [2Fe-2S] cluster binding site [ion binding]; other site 1114970005763 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1114970005764 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1114970005765 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1114970005766 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1114970005767 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114970005768 catalytic residue [active] 1114970005769 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1114970005770 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1114970005771 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1114970005772 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 1114970005773 active site 1114970005774 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 1114970005775 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 1114970005776 putative catalytic residue [active] 1114970005777 classical (c) SDR, subgroup 10; Region: SDR_c10; cd05373 1114970005778 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1114970005779 putative NAD(P) binding site [chemical binding]; other site 1114970005780 active site 1114970005781 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970005782 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114970005783 threonine and homoserine efflux system; Provisional; Region: PRK10532 1114970005784 EamA-like transporter family; Region: EamA; pfam00892 1114970005785 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 1114970005786 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898 1114970005787 putative hydrophobic ligand binding site [chemical binding]; other site 1114970005788 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1114970005789 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1114970005790 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970005791 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970005792 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1114970005793 classical (c) SDRs; Region: SDR_c; cd05233 1114970005794 NAD(P) binding site [chemical binding]; other site 1114970005795 active site 1114970005796 Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512 1114970005797 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1114970005798 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1114970005799 conserved cys residue [active] 1114970005800 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1114970005801 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1114970005802 conserved cys residue [active] 1114970005803 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970005804 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970005805 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1114970005806 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1114970005807 MULE transposase domain; Region: MULE; pfam10551 1114970005808 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1114970005809 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1114970005810 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1114970005811 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1114970005812 NAD binding site [chemical binding]; other site 1114970005813 homodimer interface [polypeptide binding]; other site 1114970005814 active site 1114970005815 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1114970005816 Cupin-like domain; Region: Cupin_8; pfam13621 1114970005817 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1114970005818 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970005819 S-adenosylmethionine binding site [chemical binding]; other site 1114970005820 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1114970005821 Serine hydrolase; Region: Ser_hydrolase; cl17834 1114970005822 Condensation domain; Region: Condensation; pfam00668 1114970005823 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114970005824 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114970005825 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1114970005826 acyl-activating enzyme (AAE) consensus motif; other site 1114970005827 AMP binding site [chemical binding]; other site 1114970005828 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114970005829 Condensation domain; Region: Condensation; pfam00668 1114970005830 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114970005831 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1114970005832 Condensation domain; Region: Condensation; pfam00668 1114970005833 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114970005834 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1114970005835 acyl-activating enzyme (AAE) consensus motif; other site 1114970005836 AMP binding site [chemical binding]; other site 1114970005837 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114970005838 Condensation domain; Region: Condensation; pfam00668 1114970005839 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114970005840 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1114970005841 Condensation domain; Region: Condensation; pfam00668 1114970005842 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114970005843 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1114970005844 acyl-activating enzyme (AAE) consensus motif; other site 1114970005845 AMP binding site [chemical binding]; other site 1114970005846 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114970005847 Condensation domain; Region: Condensation; pfam00668 1114970005848 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114970005849 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114970005850 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1114970005851 acyl-activating enzyme (AAE) consensus motif; other site 1114970005852 AMP binding site [chemical binding]; other site 1114970005853 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114970005854 Condensation domain; Region: Condensation; pfam00668 1114970005855 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114970005856 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114970005857 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1114970005858 acyl-activating enzyme (AAE) consensus motif; other site 1114970005859 AMP binding site [chemical binding]; other site 1114970005860 Condensation domain; Region: Condensation; pfam00668 1114970005861 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114970005862 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1114970005863 Condensation domain; Region: Condensation; pfam00668 1114970005864 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114970005865 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 1114970005866 acyl-activating enzyme (AAE) consensus motif; other site 1114970005867 AMP binding site [chemical binding]; other site 1114970005868 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114970005869 Condensation domain; Region: Condensation; pfam00668 1114970005870 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114970005871 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114970005872 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1114970005873 Condensation domain; Region: Condensation; pfam00668 1114970005874 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1114970005875 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1114970005876 acyl-activating enzyme (AAE) consensus motif; other site 1114970005877 AMP binding site [chemical binding]; other site 1114970005878 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114970005879 Secretin and TonB N terminus short domain; Region: STN; smart00965 1114970005880 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1114970005881 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970005882 N-terminal plug; other site 1114970005883 ligand-binding site [chemical binding]; other site 1114970005884 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1114970005885 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114970005886 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1114970005887 acyl-activating enzyme (AAE) consensus motif; other site 1114970005888 AMP binding site [chemical binding]; other site 1114970005889 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114970005890 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 1114970005891 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1114970005892 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1114970005893 Walker A/P-loop; other site 1114970005894 ATP binding site [chemical binding]; other site 1114970005895 Q-loop/lid; other site 1114970005896 ABC transporter signature motif; other site 1114970005897 Walker B; other site 1114970005898 D-loop; other site 1114970005899 H-loop/switch region; other site 1114970005900 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1114970005901 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1114970005902 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1114970005903 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1114970005904 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114970005905 catalytic residue [active] 1114970005906 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1114970005907 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1114970005908 active site 1114970005909 dimer interface [polypeptide binding]; other site 1114970005910 Colicin-E5 Imm protein; Region: ImmE5; pfam11480 1114970005911 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1114970005912 RHS protein; Region: RHS; pfam03527 1114970005913 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1114970005914 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1114970005915 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1114970005916 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1114970005917 Walker A/P-loop; other site 1114970005918 ATP binding site [chemical binding]; other site 1114970005919 Q-loop/lid; other site 1114970005920 ABC transporter signature motif; other site 1114970005921 Walker B; other site 1114970005922 D-loop; other site 1114970005923 H-loop/switch region; other site 1114970005924 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1114970005925 FtsX-like permease family; Region: FtsX; pfam02687 1114970005926 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1114970005927 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1114970005928 HlyD family secretion protein; Region: HlyD_3; pfam13437 1114970005929 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970005930 RNA polymerase sigma factor; Reviewed; Region: PRK12527 1114970005931 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114970005932 DNA binding residues [nucleotide binding] 1114970005933 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 1114970005934 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1114970005935 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970005936 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970005937 substrate binding pocket [chemical binding]; other site 1114970005938 membrane-bound complex binding site; other site 1114970005939 hinge residues; other site 1114970005940 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970005941 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970005942 substrate binding pocket [chemical binding]; other site 1114970005943 membrane-bound complex binding site; other site 1114970005944 hinge residues; other site 1114970005945 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114970005946 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970005947 dimer interface [polypeptide binding]; other site 1114970005948 phosphorylation site [posttranslational modification] 1114970005949 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970005950 ATP binding site [chemical binding]; other site 1114970005951 Mg2+ binding site [ion binding]; other site 1114970005952 G-X-G motif; other site 1114970005953 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970005954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970005955 active site 1114970005956 phosphorylation site [posttranslational modification] 1114970005957 intermolecular recognition site; other site 1114970005958 dimerization interface [polypeptide binding]; other site 1114970005959 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1114970005960 putative binding surface; other site 1114970005961 active site 1114970005962 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1114970005963 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114970005964 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970005965 active site 1114970005966 phosphorylation site [posttranslational modification] 1114970005967 intermolecular recognition site; other site 1114970005968 dimerization interface [polypeptide binding]; other site 1114970005969 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970005970 DNA binding residues [nucleotide binding] 1114970005971 dimerization interface [polypeptide binding]; other site 1114970005972 Pirin-related protein [General function prediction only]; Region: COG1741 1114970005973 Pirin; Region: Pirin; pfam02678 1114970005974 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1114970005975 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1114970005976 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1114970005977 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1114970005978 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1114970005979 ligand binding site [chemical binding]; other site 1114970005980 flexible hinge region; other site 1114970005981 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1114970005982 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1114970005983 RNA polymerase sigma factor; Reviewed; Region: PRK12527 1114970005984 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970005985 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114970005986 DNA binding residues [nucleotide binding] 1114970005987 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1114970005988 FecR protein; Region: FecR; pfam04773 1114970005989 Secretin and TonB N terminus short domain; Region: STN; smart00965 1114970005990 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 1114970005991 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970005992 N-terminal plug; other site 1114970005993 ligand-binding site [chemical binding]; other site 1114970005994 diaminopimelate epimerase; Provisional; Region: PRK13577 1114970005995 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1114970005996 cytosine deaminase; Provisional; Region: PRK09230 1114970005997 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1114970005998 active site 1114970005999 cytosine permease; Provisional; Region: codB; PRK11017 1114970006000 Na binding site [ion binding]; other site 1114970006001 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1114970006002 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1114970006003 active site 1114970006004 Predicted membrane protein [Function unknown]; Region: COG3212 1114970006005 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1114970006006 Predicted membrane protein [Function unknown]; Region: COG3212 1114970006007 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1114970006008 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114970006009 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970006010 active site 1114970006011 phosphorylation site [posttranslational modification] 1114970006012 intermolecular recognition site; other site 1114970006013 dimerization interface [polypeptide binding]; other site 1114970006014 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970006015 DNA binding site [nucleotide binding] 1114970006016 sensor protein PhoQ; Provisional; Region: PRK10815 1114970006017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970006018 ATP binding site [chemical binding]; other site 1114970006019 G-X-G motif; other site 1114970006020 Predicted permease [General function prediction only]; Region: COG2056 1114970006021 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1114970006022 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1114970006023 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970006024 dimerization interface [polypeptide binding]; other site 1114970006025 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970006026 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970006027 dimer interface [polypeptide binding]; other site 1114970006028 putative CheW interface [polypeptide binding]; other site 1114970006029 putative protease; Provisional; Region: PRK15452 1114970006030 Peptidase family U32; Region: Peptidase_U32; pfam01136 1114970006031 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1114970006032 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1114970006033 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1114970006034 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970006035 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970006036 homodimer interface [polypeptide binding]; other site 1114970006037 catalytic residue [active] 1114970006038 excinuclease ABC subunit B; Provisional; Region: PRK05298 1114970006039 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114970006040 ATP binding site [chemical binding]; other site 1114970006041 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114970006042 nucleotide binding region [chemical binding]; other site 1114970006043 ATP-binding site [chemical binding]; other site 1114970006044 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1114970006045 UvrB/uvrC motif; Region: UVR; pfam02151 1114970006046 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1114970006047 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1114970006048 active site 1114970006049 HIGH motif; other site 1114970006050 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1114970006051 active site 1114970006052 KMSKS motif; other site 1114970006053 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970006054 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114970006055 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1114970006056 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114970006057 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1114970006058 active site 1114970006059 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1114970006060 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1114970006061 FMN binding site [chemical binding]; other site 1114970006062 active site 1114970006063 catalytic residues [active] 1114970006064 substrate binding site [chemical binding]; other site 1114970006065 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1114970006066 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1114970006067 putative dimer interface [polypeptide binding]; other site 1114970006068 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970006069 PAS fold; Region: PAS_3; pfam08447 1114970006070 putative active site [active] 1114970006071 heme pocket [chemical binding]; other site 1114970006072 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1114970006073 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970006074 putative active site [active] 1114970006075 heme pocket [chemical binding]; other site 1114970006076 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1114970006077 PAS domain S-box; Region: sensory_box; TIGR00229 1114970006078 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970006079 putative active site [active] 1114970006080 heme pocket [chemical binding]; other site 1114970006081 PAS domain S-box; Region: sensory_box; TIGR00229 1114970006082 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970006083 putative active site [active] 1114970006084 heme pocket [chemical binding]; other site 1114970006085 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114970006086 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970006087 metal binding site [ion binding]; metal-binding site 1114970006088 active site 1114970006089 I-site; other site 1114970006090 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970006091 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970006092 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970006093 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1114970006094 dimerization interface [polypeptide binding]; other site 1114970006095 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1114970006096 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1114970006097 substrate binding site [chemical binding]; other site 1114970006098 ligand binding site [chemical binding]; other site 1114970006099 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1114970006100 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1114970006101 substrate binding site [chemical binding]; other site 1114970006102 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1114970006103 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970006104 S-adenosylmethionine binding site [chemical binding]; other site 1114970006105 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1114970006106 tartrate dehydrogenase; Region: TTC; TIGR02089 1114970006107 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1114970006108 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1114970006109 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK05671 1114970006110 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1114970006111 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 1114970006112 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114970006113 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 1114970006114 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1114970006115 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1114970006116 dimerization interface 3.5A [polypeptide binding]; other site 1114970006117 active site 1114970006118 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1114970006119 active site 1114970006120 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1114970006121 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1114970006122 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1114970006123 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1114970006124 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1114970006125 Sporulation related domain; Region: SPOR; pfam05036 1114970006126 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1114970006127 Colicin V production protein; Region: Colicin_V; cl00567 1114970006128 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1114970006129 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1114970006130 active site 1114970006131 tetramer interface [polypeptide binding]; other site 1114970006132 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114970006133 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1114970006134 active site 1114970006135 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 1114970006136 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1114970006137 homodimer interface [polypeptide binding]; other site 1114970006138 substrate-cofactor binding pocket; other site 1114970006139 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970006140 catalytic residue [active] 1114970006141 oxidoreductase; Validated; Region: PRK05717 1114970006142 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970006143 NAD(P) binding site [chemical binding]; other site 1114970006144 active site 1114970006145 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1114970006146 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1114970006147 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1114970006148 Protein present in Fab1, YOTB, Vac1, and EEA1; Region: FYVE; smart00064 1114970006149 FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1; Region: FYVE; cd00065 1114970006150 Zn binding sites [ion binding]; other site 1114970006151 phosphatidylinositol 3-phosphate binding site [chemical binding]; other site 1114970006152 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114970006153 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970006154 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 1114970006155 probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684 1114970006156 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 1114970006157 Domain of unknown function (DUF4410); Region: DUF4410; pfam14366 1114970006158 AAA domain; Region: AAA_17; pfam13207 1114970006159 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1114970006160 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1114970006161 Putative amidotransferase; Region: DUF4066; pfam13278 1114970006162 conserved cys residue [active] 1114970006163 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 1114970006164 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1114970006165 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970006166 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1114970006167 dimerization interface [polypeptide binding]; other site 1114970006168 substrate binding pocket [chemical binding]; other site 1114970006169 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1114970006170 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1114970006171 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1114970006172 protein binding site [polypeptide binding]; other site 1114970006173 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 1114970006174 FRG domain; Region: FRG; pfam08867 1114970006175 AzlC protein; Region: AzlC; cl00570 1114970006176 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 1114970006177 H+ Antiporter protein; Region: 2A0121; TIGR00900 1114970006178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970006179 putative substrate translocation pore; other site 1114970006180 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 1114970006181 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1114970006182 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970006183 Walker A motif; other site 1114970006184 ATP binding site [chemical binding]; other site 1114970006185 Walker B motif; other site 1114970006186 arginine finger; other site 1114970006187 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1114970006188 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1114970006189 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1114970006190 Walker A/P-loop; other site 1114970006191 ATP binding site [chemical binding]; other site 1114970006192 Q-loop/lid; other site 1114970006193 ABC transporter signature motif; other site 1114970006194 Walker B; other site 1114970006195 D-loop; other site 1114970006196 H-loop/switch region; other site 1114970006197 TOBE domain; Region: TOBE_2; pfam08402 1114970006198 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1114970006199 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1114970006200 Walker A/P-loop; other site 1114970006201 ATP binding site [chemical binding]; other site 1114970006202 Q-loop/lid; other site 1114970006203 ABC transporter signature motif; other site 1114970006204 Walker B; other site 1114970006205 D-loop; other site 1114970006206 H-loop/switch region; other site 1114970006207 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1114970006208 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970006209 putative PBP binding loops; other site 1114970006210 dimer interface [polypeptide binding]; other site 1114970006211 ABC-ATPase subunit interface; other site 1114970006212 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1114970006213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970006214 dimer interface [polypeptide binding]; other site 1114970006215 conserved gate region; other site 1114970006216 putative PBP binding loops; other site 1114970006217 ABC-ATPase subunit interface; other site 1114970006218 Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928 1114970006219 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1114970006220 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1114970006221 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1114970006222 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1114970006223 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 1114970006224 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1114970006225 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1114970006226 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1114970006227 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1114970006228 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1114970006229 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1114970006230 putative active site [active] 1114970006231 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 1114970006232 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1114970006233 DXD motif; other site 1114970006234 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 1114970006235 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1114970006236 active site 1114970006237 O-Antigen ligase; Region: Wzy_C; pfam04932 1114970006238 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1114970006239 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1114970006240 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114970006241 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1114970006242 Chain length determinant protein; Region: Wzz; cl15801 1114970006243 Chain length determinant protein; Region: Wzz; cl15801 1114970006244 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1114970006245 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 1114970006246 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1114970006247 SLBB domain; Region: SLBB; pfam10531 1114970006248 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 1114970006249 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1114970006250 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1114970006251 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 1114970006252 putative NAD(P) binding site [chemical binding]; other site 1114970006253 active site 1114970006254 putative substrate binding site [chemical binding]; other site 1114970006255 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1114970006256 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1114970006257 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1114970006258 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1114970006259 Sulfatase; Region: Sulfatase; cl17466 1114970006260 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1114970006261 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1114970006262 Walker A/P-loop; other site 1114970006263 ATP binding site [chemical binding]; other site 1114970006264 Q-loop/lid; other site 1114970006265 ABC transporter signature motif; other site 1114970006266 Walker B; other site 1114970006267 D-loop; other site 1114970006268 H-loop/switch region; other site 1114970006269 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1114970006270 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 1114970006271 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1114970006272 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 1114970006273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1114970006274 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 1114970006275 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1114970006276 Cysteine-rich domain; Region: CCG; pfam02754 1114970006277 Cysteine-rich domain; Region: CCG; pfam02754 1114970006278 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 1114970006279 FAD binding domain; Region: FAD_binding_4; pfam01565 1114970006280 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 1114970006281 FAD binding domain; Region: FAD_binding_4; pfam01565 1114970006282 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114970006283 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1114970006284 MASE2 domain; Region: MASE2; pfam05230 1114970006285 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114970006286 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970006287 metal binding site [ion binding]; metal-binding site 1114970006288 active site 1114970006289 I-site; other site 1114970006290 glutamate carboxypeptidase; Reviewed; Region: PRK06133 1114970006291 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 1114970006292 metal binding site [ion binding]; metal-binding site 1114970006293 dimer interface [polypeptide binding]; other site 1114970006294 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 1114970006295 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1114970006296 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1114970006297 ligand binding site [chemical binding]; other site 1114970006298 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1114970006299 putative catalytic site [active] 1114970006300 putative phosphate binding site [ion binding]; other site 1114970006301 active site 1114970006302 metal binding site A [ion binding]; metal-binding site 1114970006303 DNA binding site [nucleotide binding] 1114970006304 putative AP binding site [nucleotide binding]; other site 1114970006305 putative metal binding site B [ion binding]; other site 1114970006306 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1114970006307 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1114970006308 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1114970006309 Surface antigen; Region: Bac_surface_Ag; pfam01103 1114970006310 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1114970006311 Family of unknown function (DUF490); Region: DUF490; pfam04357 1114970006312 MarR family; Region: MarR_2; cl17246 1114970006313 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114970006314 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1114970006315 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 1114970006316 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1114970006317 HlyD family secretion protein; Region: HlyD_3; pfam13437 1114970006318 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1114970006319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970006320 putative substrate translocation pore; other site 1114970006321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970006322 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1114970006323 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1114970006324 putative active site [active] 1114970006325 putative metal binding site [ion binding]; other site 1114970006326 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1114970006327 substrate binding site [chemical binding]; other site 1114970006328 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1114970006329 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1114970006330 active site 1114970006331 HIGH motif; other site 1114970006332 nucleotide binding site [chemical binding]; other site 1114970006333 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1114970006334 KMSKS motif; other site 1114970006335 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1114970006336 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1114970006337 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1114970006338 active site 1114970006339 HIGH motif; other site 1114970006340 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1114970006341 KMSKS motif; other site 1114970006342 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1114970006343 tRNA binding surface [nucleotide binding]; other site 1114970006344 anticodon binding site; other site 1114970006345 Predicted membrane protein (DUF2214); Region: DUF2214; cl01427 1114970006346 carbon storage regulator; Provisional; Region: PRK01712 1114970006347 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 1114970006348 DNA-specific endonuclease I; Provisional; Region: PRK15137 1114970006349 Protein of unknown function (DUF1654); Region: DUF1654; pfam07867 1114970006350 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1114970006351 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1114970006352 ligand binding site [chemical binding]; other site 1114970006353 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1114970006354 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1114970006355 Walker A/P-loop; other site 1114970006356 ATP binding site [chemical binding]; other site 1114970006357 Q-loop/lid; other site 1114970006358 ABC transporter signature motif; other site 1114970006359 Walker B; other site 1114970006360 D-loop; other site 1114970006361 H-loop/switch region; other site 1114970006362 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1114970006363 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1114970006364 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1114970006365 TM-ABC transporter signature motif; other site 1114970006366 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114970006367 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114970006368 DNA binding site [nucleotide binding] 1114970006369 domain linker motif; other site 1114970006370 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1114970006371 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1114970006372 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1114970006373 substrate binding site [chemical binding]; other site 1114970006374 dimer interface [polypeptide binding]; other site 1114970006375 ATP binding site [chemical binding]; other site 1114970006376 D-ribose pyranase; Provisional; Region: PRK11797 1114970006377 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1114970006378 active site 1114970006379 tetramer interface [polypeptide binding]; other site 1114970006380 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 1114970006381 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1114970006382 DNA-binding site [nucleotide binding]; DNA binding site 1114970006383 RNA-binding motif; other site 1114970006384 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1114970006385 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1114970006386 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1114970006387 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1114970006388 active site 1114970006389 dimer interface [polypeptide binding]; other site 1114970006390 motif 1; other site 1114970006391 motif 2; other site 1114970006392 motif 3; other site 1114970006393 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1114970006394 anticodon binding site; other site 1114970006395 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1114970006396 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1114970006397 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1114970006398 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1114970006399 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1114970006400 23S rRNA binding site [nucleotide binding]; other site 1114970006401 L21 binding site [polypeptide binding]; other site 1114970006402 L13 binding site [polypeptide binding]; other site 1114970006403 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1114970006404 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1114970006405 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1114970006406 dimer interface [polypeptide binding]; other site 1114970006407 motif 1; other site 1114970006408 active site 1114970006409 motif 2; other site 1114970006410 motif 3; other site 1114970006411 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1114970006412 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1114970006413 putative tRNA-binding site [nucleotide binding]; other site 1114970006414 B3/4 domain; Region: B3_4; pfam03483 1114970006415 tRNA synthetase B5 domain; Region: B5; smart00874 1114970006416 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1114970006417 dimer interface [polypeptide binding]; other site 1114970006418 motif 1; other site 1114970006419 motif 3; other site 1114970006420 motif 2; other site 1114970006421 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1114970006422 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1114970006423 IHF - DNA interface [nucleotide binding]; other site 1114970006424 IHF dimer interface [polypeptide binding]; other site 1114970006425 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 1114970006426 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1114970006427 DNA binding residues [nucleotide binding] 1114970006428 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 1114970006429 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1114970006430 putative ligand binding site [chemical binding]; other site 1114970006431 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1114970006432 short chain dehydrogenase; Provisional; Region: PRK06198 1114970006433 classical (c) SDRs; Region: SDR_c; cd05233 1114970006434 NAD(P) binding site [chemical binding]; other site 1114970006435 active site 1114970006436 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114970006437 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114970006438 DNA binding site [nucleotide binding] 1114970006439 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 1114970006440 putative ligand binding site [chemical binding]; other site 1114970006441 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1114970006442 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1114970006443 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 1114970006444 active site 1114970006445 dimer interface [polypeptide binding]; other site 1114970006446 metal binding site [ion binding]; metal-binding site 1114970006447 SnoaL-like domain; Region: SnoaL_3; pfam13474 1114970006448 SnoaL-like domain; Region: SnoaL_2; pfam12680 1114970006449 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1114970006450 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 1114970006451 active site 1114970006452 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970006453 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970006454 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1114970006455 putative effector binding pocket; other site 1114970006456 dimerization interface [polypeptide binding]; other site 1114970006457 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 1114970006458 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1114970006459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970006460 putative substrate translocation pore; other site 1114970006461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970006462 Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461 1114970006463 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 1114970006464 dimer interface [polypeptide binding]; other site 1114970006465 active site 1114970006466 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1114970006467 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1114970006468 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1114970006469 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1114970006470 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1114970006471 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1114970006472 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1114970006473 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 1114970006474 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1114970006475 putative ligand binding site [chemical binding]; other site 1114970006476 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 1114970006477 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1114970006478 Walker A/P-loop; other site 1114970006479 ATP binding site [chemical binding]; other site 1114970006480 Q-loop/lid; other site 1114970006481 ABC transporter signature motif; other site 1114970006482 Walker B; other site 1114970006483 D-loop; other site 1114970006484 H-loop/switch region; other site 1114970006485 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1114970006486 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism]; Region: AraH; COG1172 1114970006487 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1114970006488 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1114970006489 TM-ABC transporter signature motif; other site 1114970006490 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 1114970006491 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1114970006492 active site 1114970006493 DNA binding site [nucleotide binding] 1114970006494 Int/Topo IB signature motif; other site 1114970006495 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114970006496 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970006497 active site 1114970006498 phosphorylation site [posttranslational modification] 1114970006499 intermolecular recognition site; other site 1114970006500 dimerization interface [polypeptide binding]; other site 1114970006501 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970006502 DNA binding residues [nucleotide binding] 1114970006503 dimerization interface [polypeptide binding]; other site 1114970006504 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1114970006505 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1114970006506 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970006507 dimer interface [polypeptide binding]; other site 1114970006508 phosphorylation site [posttranslational modification] 1114970006509 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970006510 ATP binding site [chemical binding]; other site 1114970006511 Mg2+ binding site [ion binding]; other site 1114970006512 G-X-G motif; other site 1114970006513 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970006514 active site 1114970006515 phosphorylation site [posttranslational modification] 1114970006516 intermolecular recognition site; other site 1114970006517 dimerization interface [polypeptide binding]; other site 1114970006518 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1114970006519 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1114970006520 putative ligand binding site [chemical binding]; other site 1114970006521 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1114970006522 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1114970006523 TM-ABC transporter signature motif; other site 1114970006524 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1114970006525 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1114970006526 TM-ABC transporter signature motif; other site 1114970006527 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1114970006528 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1114970006529 Walker A/P-loop; other site 1114970006530 ATP binding site [chemical binding]; other site 1114970006531 Q-loop/lid; other site 1114970006532 ABC transporter signature motif; other site 1114970006533 Walker B; other site 1114970006534 D-loop; other site 1114970006535 H-loop/switch region; other site 1114970006536 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1114970006537 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1114970006538 Walker A/P-loop; other site 1114970006539 ATP binding site [chemical binding]; other site 1114970006540 Q-loop/lid; other site 1114970006541 ABC transporter signature motif; other site 1114970006542 Walker B; other site 1114970006543 D-loop; other site 1114970006544 H-loop/switch region; other site 1114970006545 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 1114970006546 acylamide amidohydrolase; Provisional; Region: amiE; PRK13286 1114970006547 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 1114970006548 multimer interface [polypeptide binding]; other site 1114970006549 active site 1114970006550 catalytic triad [active] 1114970006551 dimer interface [polypeptide binding]; other site 1114970006552 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1114970006553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970006554 Walker A motif; other site 1114970006555 ATP binding site [chemical binding]; other site 1114970006556 Walker B motif; other site 1114970006557 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1114970006558 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114970006559 dimerization interface [polypeptide binding]; other site 1114970006560 putative DNA binding site [nucleotide binding]; other site 1114970006561 putative Zn2+ binding site [ion binding]; other site 1114970006562 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1114970006563 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1114970006564 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114970006565 dimerization interface [polypeptide binding]; other site 1114970006566 putative DNA binding site [nucleotide binding]; other site 1114970006567 putative Zn2+ binding site [ion binding]; other site 1114970006568 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1114970006569 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1114970006570 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 1114970006571 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1114970006572 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1114970006573 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970006574 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 1114970006575 Predicted permease; Region: DUF318; cl17795 1114970006576 Predicted permease; Region: DUF318; cl17795 1114970006577 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1114970006578 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1114970006579 DKNYY family; Region: DKNYY; pfam13644 1114970006580 DKNYY family; Region: DKNYY; pfam13644 1114970006581 DKNYY family; Region: DKNYY; pfam13644 1114970006582 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 1114970006583 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 1114970006584 putative homodimer interface [polypeptide binding]; other site 1114970006585 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1114970006586 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1114970006587 active site 1114970006588 homodimer interface [polypeptide binding]; other site 1114970006589 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1114970006590 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1114970006591 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970006592 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1114970006593 NAD(P) binding site [chemical binding]; other site 1114970006594 active site 1114970006595 Predicted membrane protein [Function unknown]; Region: COG2246 1114970006596 GtrA-like protein; Region: GtrA; pfam04138 1114970006597 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1114970006598 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1114970006599 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1114970006600 Ligand binding site; other site 1114970006601 Putative Catalytic site; other site 1114970006602 DXD motif; other site 1114970006603 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 1114970006604 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114970006605 putative homodimer interface [polypeptide binding]; other site 1114970006606 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1114970006607 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1114970006608 Probable Catalytic site; other site 1114970006609 metal-binding site 1114970006610 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1114970006611 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1114970006612 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1114970006613 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1114970006614 Walker A/P-loop; other site 1114970006615 ATP binding site [chemical binding]; other site 1114970006616 Q-loop/lid; other site 1114970006617 ABC transporter signature motif; other site 1114970006618 Walker B; other site 1114970006619 D-loop; other site 1114970006620 H-loop/switch region; other site 1114970006621 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 1114970006622 putative carbohydrate binding site [chemical binding]; other site 1114970006623 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1114970006624 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1114970006625 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 1114970006626 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 1114970006627 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114970006628 putative homodimer interface [polypeptide binding]; other site 1114970006629 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1114970006630 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1114970006631 Probable Catalytic site; other site 1114970006632 metal-binding site 1114970006633 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1114970006634 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970006635 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1114970006636 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1114970006637 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1114970006638 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1114970006639 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1114970006640 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1114970006641 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1114970006642 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1114970006643 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1114970006644 Surface antigen; Region: Bac_surface_Ag; pfam01103 1114970006645 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114970006646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970006647 active site 1114970006648 phosphorylation site [posttranslational modification] 1114970006649 intermolecular recognition site; other site 1114970006650 dimerization interface [polypeptide binding]; other site 1114970006651 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970006652 DNA binding site [nucleotide binding] 1114970006653 HAMP domain; Region: HAMP; pfam00672 1114970006654 dimerization interface [polypeptide binding]; other site 1114970006655 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970006656 dimer interface [polypeptide binding]; other site 1114970006657 phosphorylation site [posttranslational modification] 1114970006658 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970006659 ATP binding site [chemical binding]; other site 1114970006660 Mg2+ binding site [ion binding]; other site 1114970006661 G-X-G motif; other site 1114970006662 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 1114970006663 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970006664 active site 1114970006665 phosphorylation site [posttranslational modification] 1114970006666 intermolecular recognition site; other site 1114970006667 dimerization interface [polypeptide binding]; other site 1114970006668 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970006669 DNA binding site [nucleotide binding] 1114970006670 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 1114970006671 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970006672 dimerization interface [polypeptide binding]; other site 1114970006673 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970006674 dimer interface [polypeptide binding]; other site 1114970006675 phosphorylation site [posttranslational modification] 1114970006676 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970006677 ATP binding site [chemical binding]; other site 1114970006678 Mg2+ binding site [ion binding]; other site 1114970006679 G-X-G motif; other site 1114970006680 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1114970006681 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1114970006682 HlyD family secretion protein; Region: HlyD_3; pfam13437 1114970006683 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1114970006684 Protein export membrane protein; Region: SecD_SecF; cl14618 1114970006685 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 1114970006686 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 1114970006687 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970006688 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 1114970006689 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970006690 NAD(P) binding site [chemical binding]; other site 1114970006691 catalytic residues [active] 1114970006692 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114970006693 C-terminal domain of type I, class II extradiol dioxygenases; catalytic domain; Region: ED_TypeI_classII_C; cd08343 1114970006694 active site 1114970006695 metal binding site [ion binding]; metal-binding site 1114970006696 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 1114970006697 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1114970006698 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1114970006699 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1114970006700 Bacterial transcriptional regulator; Region: IclR; pfam01614 1114970006701 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1114970006702 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1114970006703 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1114970006704 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1114970006705 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1114970006706 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 1114970006707 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970006708 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114970006709 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1114970006710 CoenzymeA binding site [chemical binding]; other site 1114970006711 subunit interaction site [polypeptide binding]; other site 1114970006712 PHB binding site; other site 1114970006713 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1114970006714 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1114970006715 FAD binding pocket [chemical binding]; other site 1114970006716 FAD binding motif [chemical binding]; other site 1114970006717 phosphate binding motif [ion binding]; other site 1114970006718 beta-alpha-beta structure motif; other site 1114970006719 NAD binding pocket [chemical binding]; other site 1114970006720 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1114970006721 catalytic loop [active] 1114970006722 iron binding site [ion binding]; other site 1114970006723 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1114970006724 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1114970006725 [2Fe-2S] cluster binding site [ion binding]; other site 1114970006726 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 1114970006727 putative alpha subunit interface [polypeptide binding]; other site 1114970006728 putative active site [active] 1114970006729 putative substrate binding site [chemical binding]; other site 1114970006730 Fe binding site [ion binding]; other site 1114970006731 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 1114970006732 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970006733 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970006734 dimerization interface [polypeptide binding]; other site 1114970006735 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 1114970006736 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114970006737 Walker A/P-loop; other site 1114970006738 ATP binding site [chemical binding]; other site 1114970006739 Q-loop/lid; other site 1114970006740 ABC transporter signature motif; other site 1114970006741 Walker B; other site 1114970006742 D-loop; other site 1114970006743 H-loop/switch region; other site 1114970006744 CBS domain; Region: CBS; pfam00571 1114970006745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970006746 dimer interface [polypeptide binding]; other site 1114970006747 conserved gate region; other site 1114970006748 putative PBP binding loops; other site 1114970006749 ABC-ATPase subunit interface; other site 1114970006750 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970006751 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114970006752 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1114970006753 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1114970006754 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1114970006755 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114970006756 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1114970006757 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1114970006758 substrate binding site [chemical binding]; other site 1114970006759 catalytic Zn binding site [ion binding]; other site 1114970006760 NAD binding site [chemical binding]; other site 1114970006761 structural Zn binding site [ion binding]; other site 1114970006762 dimer interface [polypeptide binding]; other site 1114970006763 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 1114970006764 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 1114970006765 putative active site [active] 1114970006766 putative FMN binding site [chemical binding]; other site 1114970006767 putative substrate binding site [chemical binding]; other site 1114970006768 putative catalytic residue [active] 1114970006769 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114970006770 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1114970006771 Ligand binding site [chemical binding]; other site 1114970006772 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1114970006773 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1114970006774 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1114970006775 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1114970006776 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1114970006777 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1114970006778 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1114970006779 Cache domain; Region: Cache_1; pfam02743 1114970006780 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970006781 dimerization interface [polypeptide binding]; other site 1114970006782 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970006783 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970006784 dimer interface [polypeptide binding]; other site 1114970006785 putative CheW interface [polypeptide binding]; other site 1114970006786 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970006787 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1114970006788 DNA-binding site [nucleotide binding]; DNA binding site 1114970006789 FCD domain; Region: FCD; pfam07729 1114970006790 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1114970006791 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1114970006792 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1114970006793 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1114970006794 Walker A/P-loop; other site 1114970006795 ATP binding site [chemical binding]; other site 1114970006796 Q-loop/lid; other site 1114970006797 ABC transporter signature motif; other site 1114970006798 Walker B; other site 1114970006799 D-loop; other site 1114970006800 H-loop/switch region; other site 1114970006801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970006802 dimer interface [polypeptide binding]; other site 1114970006803 conserved gate region; other site 1114970006804 putative PBP binding loops; other site 1114970006805 ABC-ATPase subunit interface; other site 1114970006806 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1114970006807 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970006808 dimer interface [polypeptide binding]; other site 1114970006809 conserved gate region; other site 1114970006810 ABC-ATPase subunit interface; other site 1114970006811 Possible frameshift of a hydroxyproline-2-epimerase 1114970006812 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1114970006813 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1114970006814 conserved cys residue [active] 1114970006815 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1114970006816 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970006817 DNA-binding site [nucleotide binding]; DNA binding site 1114970006818 FCD domain; Region: FCD; pfam07729 1114970006819 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1114970006820 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1114970006821 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1114970006822 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1114970006823 inhibitor site; inhibition site 1114970006824 active site 1114970006825 dimer interface [polypeptide binding]; other site 1114970006826 catalytic residue [active] 1114970006827 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970006828 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1114970006829 NAD(P) binding site [chemical binding]; other site 1114970006830 catalytic residues [active] 1114970006831 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1114970006832 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1114970006833 conserved cys residue [active] 1114970006834 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970006835 Pirin-related protein [General function prediction only]; Region: COG1741 1114970006836 Pirin; Region: Pirin; pfam02678 1114970006837 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1114970006838 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1114970006839 conserved cys residue [active] 1114970006840 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970006841 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970006842 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114970006843 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970006844 DNA binding site [nucleotide binding] 1114970006845 Predicted ATPase [General function prediction only]; Region: COG3903 1114970006846 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114970006847 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970006848 DNA binding site [nucleotide binding] 1114970006849 Predicted ATPase [General function prediction only]; Region: COG3903 1114970006850 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1114970006851 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1114970006852 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1114970006853 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970006854 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970006855 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 1114970006856 putative substrate binding pocket [chemical binding]; other site 1114970006857 putative dimerization interface [polypeptide binding]; other site 1114970006858 Predicted membrane protein [Function unknown]; Region: COG2259 1114970006859 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 1114970006860 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1114970006861 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1114970006862 active site 1114970006863 Isochorismatase family; Region: Isochorismatase; pfam00857 1114970006864 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1114970006865 catalytic triad [active] 1114970006866 dimer interface [polypeptide binding]; other site 1114970006867 conserved cis-peptide bond; other site 1114970006868 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970006869 LysR family transcriptional regulator; Provisional; Region: PRK14997 1114970006870 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1114970006871 putative effector binding pocket; other site 1114970006872 dimerization interface [polypeptide binding]; other site 1114970006873 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1114970006874 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1114970006875 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1114970006876 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1114970006877 Predicted transcriptional regulator [Transcription]; Region: COG3905 1114970006878 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1114970006879 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970006880 Coenzyme A binding pocket [chemical binding]; other site 1114970006881 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1114970006882 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1114970006883 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1114970006884 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1114970006885 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1114970006886 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1114970006887 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1114970006888 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1114970006889 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1114970006890 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1114970006891 4Fe-4S binding domain; Region: Fer4; pfam00037 1114970006892 4Fe-4S binding domain; Region: Fer4; pfam00037 1114970006893 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1114970006894 NADH dehydrogenase subunit G; Validated; Region: PRK08166 1114970006895 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1114970006896 catalytic loop [active] 1114970006897 iron binding site [ion binding]; other site 1114970006898 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1114970006899 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1114970006900 [4Fe-4S] binding site [ion binding]; other site 1114970006901 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1114970006902 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 1114970006903 SLBB domain; Region: SLBB; pfam10531 1114970006904 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1114970006905 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1114970006906 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1114970006907 putative dimer interface [polypeptide binding]; other site 1114970006908 [2Fe-2S] cluster binding site [ion binding]; other site 1114970006909 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 1114970006910 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1114970006911 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1114970006912 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 1114970006913 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1114970006914 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1114970006915 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970006916 dimerization interface [polypeptide binding]; other site 1114970006917 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970006918 dimer interface [polypeptide binding]; other site 1114970006919 putative CheW interface [polypeptide binding]; other site 1114970006920 isocitrate lyase; Provisional; Region: PRK15063 1114970006921 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1114970006922 tetramer interface [polypeptide binding]; other site 1114970006923 active site 1114970006924 Mg2+/Mn2+ binding site [ion binding]; other site 1114970006925 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1114970006926 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1114970006927 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1114970006928 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970006929 Coenzyme A binding pocket [chemical binding]; other site 1114970006930 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1114970006931 Cupin domain; Region: Cupin_2; cl17218 1114970006932 adenylosuccinate lyase; Provisional; Region: PRK09285 1114970006933 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1114970006934 tetramer interface [polypeptide binding]; other site 1114970006935 active site 1114970006936 putative lysogenization regulator; Reviewed; Region: PRK00218 1114970006937 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1114970006938 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1114970006939 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 1114970006940 nudix motif; other site 1114970006941 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1114970006942 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1114970006943 isocitrate dehydrogenase; Validated; Region: PRK07362 1114970006944 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1114970006945 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1114970006946 DNA-binding site [nucleotide binding]; DNA binding site 1114970006947 RNA-binding motif; other site 1114970006948 Uncharacterized conserved protein [Function unknown]; Region: COG2127 1114970006949 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 1114970006950 Clp amino terminal domain; Region: Clp_N; pfam02861 1114970006951 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970006952 Walker A motif; other site 1114970006953 ATP binding site [chemical binding]; other site 1114970006954 Walker B motif; other site 1114970006955 arginine finger; other site 1114970006956 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970006957 Walker A motif; other site 1114970006958 ATP binding site [chemical binding]; other site 1114970006959 Walker B motif; other site 1114970006960 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1114970006961 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1114970006962 rRNA binding site [nucleotide binding]; other site 1114970006963 predicted 30S ribosome binding site; other site 1114970006964 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 1114970006965 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 1114970006966 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 1114970006967 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1114970006968 thioredoxin reductase; Provisional; Region: PRK10262 1114970006969 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114970006970 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1114970006971 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1114970006972 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1114970006973 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1114970006974 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 1114970006975 recombination factor protein RarA; Reviewed; Region: PRK13342 1114970006976 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970006977 Walker A motif; other site 1114970006978 ATP binding site [chemical binding]; other site 1114970006979 Walker B motif; other site 1114970006980 arginine finger; other site 1114970006981 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1114970006982 camphor resistance protein CrcB; Provisional; Region: PRK14234 1114970006983 seryl-tRNA synthetase; Provisional; Region: PRK05431 1114970006984 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1114970006985 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1114970006986 dimer interface [polypeptide binding]; other site 1114970006987 active site 1114970006988 motif 1; other site 1114970006989 motif 2; other site 1114970006990 motif 3; other site 1114970006991 siroheme synthase; Provisional; Region: cysG; PRK10637 1114970006992 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1114970006993 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1114970006994 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1114970006995 active site 1114970006996 SAM binding site [chemical binding]; other site 1114970006997 homodimer interface [polypeptide binding]; other site 1114970006998 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1114970006999 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1114970007000 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1114970007001 putative dimer interface [polypeptide binding]; other site 1114970007002 N-terminal domain interface [polypeptide binding]; other site 1114970007003 putative substrate binding pocket (H-site) [chemical binding]; other site 1114970007004 hypothetical protein; Validated; Region: PRK09071 1114970007005 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1114970007006 DsrC like protein; Region: DsrC; pfam04358 1114970007007 sulfur relay protein TusB/DsrH; Region: sulf_tusB_dsrH; TIGR03011 1114970007008 sulfur relay protein TusC; Validated; Region: PRK00211 1114970007009 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 1114970007010 Part of AAA domain; Region: AAA_19; pfam13245 1114970007011 Family description; Region: UvrD_C_2; pfam13538 1114970007012 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970007013 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1114970007014 Coenzyme A binding pocket [chemical binding]; other site 1114970007015 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1114970007016 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1114970007017 Isochorismatase family; Region: Isochorismatase; pfam00857 1114970007018 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1114970007019 catalytic triad [active] 1114970007020 conserved cis-peptide bond; other site 1114970007021 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1114970007022 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 1114970007023 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1114970007024 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1114970007025 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1114970007026 EamA-like transporter family; Region: EamA; pfam00892 1114970007027 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114970007028 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970007029 dimer interface [polypeptide binding]; other site 1114970007030 phosphorylation site [posttranslational modification] 1114970007031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970007032 ATP binding site [chemical binding]; other site 1114970007033 Mg2+ binding site [ion binding]; other site 1114970007034 G-X-G motif; other site 1114970007035 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1114970007036 Domain of unknown function (DUF1850); Region: DUF1850; cl01950 1114970007037 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 1114970007038 DctM-like transporters; Region: DctM; pfam06808 1114970007039 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1114970007040 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1114970007041 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114970007042 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114970007043 DNA binding site [nucleotide binding] 1114970007044 domain linker motif; other site 1114970007045 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 1114970007046 dimerization interface [polypeptide binding]; other site 1114970007047 ligand binding site [chemical binding]; other site 1114970007048 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1114970007049 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1114970007050 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1114970007051 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1114970007052 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1114970007053 Metal-binding active site; metal-binding site 1114970007054 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1114970007055 nucleoside transporter; Region: 2A0110; TIGR00889 1114970007056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970007057 Alginate lyase; Region: Alginate_lyase2; pfam08787 1114970007058 L-lactate permease; Region: Lactate_perm; cl00701 1114970007059 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1114970007060 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1114970007061 homotrimer interaction site [polypeptide binding]; other site 1114970007062 putative active site [active] 1114970007063 Possible Frameshift 1114970007064 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114970007065 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1114970007066 active site 1114970007067 catalytic tetrad [active] 1114970007068 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1114970007069 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1114970007070 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1114970007071 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1114970007072 conserved cys residue [active] 1114970007073 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970007074 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 1114970007075 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1114970007076 TrkA-N domain; Region: TrkA_N; pfam02254 1114970007077 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1114970007078 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970007079 dimerization interface [polypeptide binding]; other site 1114970007080 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970007081 dimer interface [polypeptide binding]; other site 1114970007082 phosphorylation site [posttranslational modification] 1114970007083 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970007084 ATP binding site [chemical binding]; other site 1114970007085 Mg2+ binding site [ion binding]; other site 1114970007086 G-X-G motif; other site 1114970007087 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114970007088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970007089 active site 1114970007090 phosphorylation site [posttranslational modification] 1114970007091 intermolecular recognition site; other site 1114970007092 dimerization interface [polypeptide binding]; other site 1114970007093 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970007094 DNA binding site [nucleotide binding] 1114970007095 VacJ like lipoprotein; Region: VacJ; cl01073 1114970007096 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1114970007097 dimer interface [polypeptide binding]; other site 1114970007098 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 1114970007099 homotrimer interaction site [polypeptide binding]; other site 1114970007100 putative active site [active] 1114970007101 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970007102 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970007103 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1114970007104 putative effector binding pocket; other site 1114970007105 putative dimerization interface [polypeptide binding]; other site 1114970007106 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1114970007107 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1114970007108 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970007109 NAD binding site [chemical binding]; other site 1114970007110 catalytic residues [active] 1114970007111 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1114970007112 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1114970007113 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1114970007114 homotrimer interaction site [polypeptide binding]; other site 1114970007115 putative active site [active] 1114970007116 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812 1114970007117 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1114970007118 active site 1114970007119 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1114970007120 dimer interface [polypeptide binding]; other site 1114970007121 substrate binding site [chemical binding]; other site 1114970007122 catalytic residue [active] 1114970007123 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970007124 transcriptional activator TtdR; Provisional; Region: PRK09801 1114970007125 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970007126 dimerization interface [polypeptide binding]; other site 1114970007127 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1114970007128 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 1114970007129 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1114970007130 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1114970007131 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 1114970007132 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1114970007133 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1114970007134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970007135 dimer interface [polypeptide binding]; other site 1114970007136 conserved gate region; other site 1114970007137 putative PBP binding loops; other site 1114970007138 ABC-ATPase subunit interface; other site 1114970007139 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1114970007140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970007141 dimer interface [polypeptide binding]; other site 1114970007142 conserved gate region; other site 1114970007143 ABC-ATPase subunit interface; other site 1114970007144 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1114970007145 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1114970007146 Walker A/P-loop; other site 1114970007147 ATP binding site [chemical binding]; other site 1114970007148 Q-loop/lid; other site 1114970007149 ABC transporter signature motif; other site 1114970007150 Walker B; other site 1114970007151 D-loop; other site 1114970007152 H-loop/switch region; other site 1114970007153 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1114970007154 Walker A/P-loop; other site 1114970007155 ATP binding site [chemical binding]; other site 1114970007156 Q-loop/lid; other site 1114970007157 ABC transporter signature motif; other site 1114970007158 Walker B; other site 1114970007159 D-loop; other site 1114970007160 H-loop/switch region; other site 1114970007161 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114970007162 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1114970007163 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1114970007164 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1114970007165 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1114970007166 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1114970007167 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1114970007168 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1114970007169 acetylornithine deacetylase; Provisional; Region: PRK07522 1114970007170 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1114970007171 metal binding site [ion binding]; metal-binding site 1114970007172 putative dimer interface [polypeptide binding]; other site 1114970007173 succinic semialdehyde dehydrogenase; Region: PLN02278 1114970007174 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1114970007175 tetramerization interface [polypeptide binding]; other site 1114970007176 NAD(P) binding site [chemical binding]; other site 1114970007177 catalytic residues [active] 1114970007178 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1114970007179 tartrate dehydrogenase; Region: TTC; TIGR02089 1114970007180 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 1114970007181 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970007182 Coenzyme A binding pocket [chemical binding]; other site 1114970007183 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1114970007184 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 1114970007185 putative ligand binding site [chemical binding]; other site 1114970007186 NAD binding site [chemical binding]; other site 1114970007187 dimerization interface [polypeptide binding]; other site 1114970007188 catalytic site [active] 1114970007189 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1114970007190 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114970007191 inhibitor-cofactor binding pocket; inhibition site 1114970007192 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970007193 catalytic residue [active] 1114970007194 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1114970007195 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114970007196 putative DNA binding site [nucleotide binding]; other site 1114970007197 putative Zn2+ binding site [ion binding]; other site 1114970007198 AsnC family; Region: AsnC_trans_reg; pfam01037 1114970007199 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1114970007200 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1114970007201 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1114970007202 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970007203 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1114970007204 substrate binding pocket [chemical binding]; other site 1114970007205 membrane-bound complex binding site; other site 1114970007206 hinge residues; other site 1114970007207 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 1114970007208 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 1114970007209 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1114970007210 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970007211 N-terminal plug; other site 1114970007212 ligand-binding site [chemical binding]; other site 1114970007213 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 1114970007214 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970007215 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970007216 dimerization interface [polypeptide binding]; other site 1114970007217 AzlC protein; Region: AzlC; pfam03591 1114970007218 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 1114970007219 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970007220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970007221 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970007222 putative substrate translocation pore; other site 1114970007223 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970007224 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970007225 dimerization interface [polypeptide binding]; other site 1114970007226 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1114970007227 classical (c) SDRs; Region: SDR_c; cd05233 1114970007228 NAD(P) binding site [chemical binding]; other site 1114970007229 active site 1114970007230 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970007231 Coenzyme A binding pocket [chemical binding]; other site 1114970007232 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1114970007233 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970007234 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970007235 dimerization interface [polypeptide binding]; other site 1114970007236 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1114970007237 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1114970007238 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1114970007239 Transposase; Region: HTH_Tnp_1; pfam01527 1114970007240 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1114970007241 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1114970007242 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1114970007243 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1114970007244 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1114970007245 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1114970007246 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1114970007247 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1114970007248 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970007249 phosphorylation site [posttranslational modification] 1114970007250 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1114970007251 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970007252 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970007253 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970007254 dimerization interface [polypeptide binding]; other site 1114970007255 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1114970007256 EamA-like transporter family; Region: EamA; pfam00892 1114970007257 EamA-like transporter family; Region: EamA; pfam00892 1114970007258 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1114970007259 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970007260 active site 1114970007261 phosphorylation site [posttranslational modification] 1114970007262 intermolecular recognition site; other site 1114970007263 dimerization interface [polypeptide binding]; other site 1114970007264 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970007265 DNA binding residues [nucleotide binding] 1114970007266 dimerization interface [polypeptide binding]; other site 1114970007267 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114970007268 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970007269 dimer interface [polypeptide binding]; other site 1114970007270 phosphorylation site [posttranslational modification] 1114970007271 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970007272 ATP binding site [chemical binding]; other site 1114970007273 Mg2+ binding site [ion binding]; other site 1114970007274 G-X-G motif; other site 1114970007275 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1114970007276 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1114970007277 Walker A/P-loop; other site 1114970007278 ATP binding site [chemical binding]; other site 1114970007279 Q-loop/lid; other site 1114970007280 ABC transporter signature motif; other site 1114970007281 Walker B; other site 1114970007282 D-loop; other site 1114970007283 H-loop/switch region; other site 1114970007284 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 1114970007285 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 1114970007286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970007287 dimer interface [polypeptide binding]; other site 1114970007288 conserved gate region; other site 1114970007289 putative PBP binding loops; other site 1114970007290 ABC-ATPase subunit interface; other site 1114970007291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970007292 dimer interface [polypeptide binding]; other site 1114970007293 conserved gate region; other site 1114970007294 putative PBP binding loops; other site 1114970007295 ABC-ATPase subunit interface; other site 1114970007296 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1114970007297 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970007298 active site 1114970007299 phosphorylation site [posttranslational modification] 1114970007300 intermolecular recognition site; other site 1114970007301 dimerization interface [polypeptide binding]; other site 1114970007302 CheB methylesterase; Region: CheB_methylest; pfam01339 1114970007303 CheD chemotactic sensory transduction; Region: CheD; cl00810 1114970007304 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1114970007305 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1114970007306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970007307 S-adenosylmethionine binding site [chemical binding]; other site 1114970007308 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1114970007309 putative CheA interaction surface; other site 1114970007310 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1114970007311 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970007312 dimerization interface [polypeptide binding]; other site 1114970007313 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970007314 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970007315 dimer interface [polypeptide binding]; other site 1114970007316 putative CheW interface [polypeptide binding]; other site 1114970007317 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1114970007318 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1114970007319 putative binding surface; other site 1114970007320 active site 1114970007321 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1114970007322 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970007323 ATP binding site [chemical binding]; other site 1114970007324 Mg2+ binding site [ion binding]; other site 1114970007325 G-X-G motif; other site 1114970007326 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1114970007327 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1114970007328 anti sigma factor interaction site; other site 1114970007329 regulatory phosphorylation site [posttranslational modification]; other site 1114970007330 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970007331 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970007332 active site 1114970007333 phosphorylation site [posttranslational modification] 1114970007334 intermolecular recognition site; other site 1114970007335 dimerization interface [polypeptide binding]; other site 1114970007336 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1114970007337 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1114970007338 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1114970007339 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1114970007340 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 1114970007341 Protein of unknown function (DUF3087); Region: DUF3087; pfam11286 1114970007342 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1114970007343 active site 1114970007344 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 1114970007345 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 1114970007346 active site 1114970007347 DNA binding site [nucleotide binding] 1114970007348 Int/Topo IB signature motif; other site 1114970007349 catalytic residues [active] 1114970007350 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 1114970007351 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114970007352 Walker A/P-loop; other site 1114970007353 ATP binding site [chemical binding]; other site 1114970007354 Q-loop/lid; other site 1114970007355 ABC transporter signature motif; other site 1114970007356 Walker B; other site 1114970007357 D-loop; other site 1114970007358 H-loop/switch region; other site 1114970007359 TOBE domain; Region: TOBE; cl01440 1114970007360 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1114970007361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970007362 dimer interface [polypeptide binding]; other site 1114970007363 conserved gate region; other site 1114970007364 putative PBP binding loops; other site 1114970007365 ABC-ATPase subunit interface; other site 1114970007366 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1114970007367 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1114970007368 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1114970007369 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1114970007370 FMN binding site [chemical binding]; other site 1114970007371 substrate binding site [chemical binding]; other site 1114970007372 putative catalytic residue [active] 1114970007373 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1114970007374 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 1114970007375 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1114970007376 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970007377 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1114970007378 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1114970007379 DNA binding site [nucleotide binding] 1114970007380 active site 1114970007381 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 1114970007382 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 1114970007383 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1114970007384 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 1114970007385 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1114970007386 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1114970007387 active site 1114970007388 tetramer interface; other site 1114970007389 glutathione reductase; Validated; Region: PRK06116 1114970007390 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1114970007391 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114970007392 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1114970007393 peroxiredoxin; Region: AhpC; TIGR03137 1114970007394 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1114970007395 dimer interface [polypeptide binding]; other site 1114970007396 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1114970007397 catalytic triad [active] 1114970007398 peroxidatic and resolving cysteines [active] 1114970007399 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1114970007400 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1114970007401 catalytic residue [active] 1114970007402 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1114970007403 catalytic residues [active] 1114970007404 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1114970007405 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114970007406 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1114970007407 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114970007408 dimer interface [polypeptide binding]; other site 1114970007409 active site 1114970007410 metal binding site [ion binding]; metal-binding site 1114970007411 glutathione binding site [chemical binding]; other site 1114970007412 phage resistance protein; Provisional; Region: PRK10551 1114970007413 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1114970007414 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970007415 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970007416 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970007417 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1114970007418 dimerization interface [polypeptide binding]; other site 1114970007419 EamA-like transporter family; Region: EamA; pfam00892 1114970007420 EamA-like transporter family; Region: EamA; pfam00892 1114970007421 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 1114970007422 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1114970007423 dimer interface [polypeptide binding]; other site 1114970007424 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1114970007425 active site 1114970007426 Fe binding site [ion binding]; other site 1114970007427 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1114970007428 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114970007429 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1114970007430 active site 1114970007431 catalytic tetrad [active] 1114970007432 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1114970007433 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970007434 putative substrate translocation pore; other site 1114970007435 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1114970007436 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1114970007437 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1114970007438 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1114970007439 aspartate aminotransferase; Provisional; Region: PRK05764 1114970007440 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970007441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970007442 homodimer interface [polypeptide binding]; other site 1114970007443 catalytic residue [active] 1114970007444 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114970007445 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970007446 active site 1114970007447 phosphorylation site [posttranslational modification] 1114970007448 intermolecular recognition site; other site 1114970007449 dimerization interface [polypeptide binding]; other site 1114970007450 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970007451 DNA binding site [nucleotide binding] 1114970007452 sensor protein RstB; Provisional; Region: PRK10604 1114970007453 HAMP domain; Region: HAMP; pfam00672 1114970007454 dimerization interface [polypeptide binding]; other site 1114970007455 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970007456 dimer interface [polypeptide binding]; other site 1114970007457 phosphorylation site [posttranslational modification] 1114970007458 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970007459 ATP binding site [chemical binding]; other site 1114970007460 Mg2+ binding site [ion binding]; other site 1114970007461 G-X-G motif; other site 1114970007462 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 1114970007463 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1114970007464 Isochorismatase family; Region: Isochorismatase; pfam00857 1114970007465 catalytic triad [active] 1114970007466 metal binding site [ion binding]; metal-binding site 1114970007467 conserved cis-peptide bond; other site 1114970007468 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1114970007469 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1114970007470 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1114970007471 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114970007472 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970007473 metal binding site [ion binding]; metal-binding site 1114970007474 active site 1114970007475 I-site; other site 1114970007476 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970007477 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1114970007478 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1114970007479 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 1114970007480 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1114970007481 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1114970007482 active site 1114970007483 Zn binding site [ion binding]; other site 1114970007484 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1114970007485 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1114970007486 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114970007487 dimerization interface [polypeptide binding]; other site 1114970007488 putative DNA binding site [nucleotide binding]; other site 1114970007489 putative Zn2+ binding site [ion binding]; other site 1114970007490 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1114970007491 Helix-turn-helix domain; Region: HTH_18; pfam12833 1114970007492 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970007493 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1114970007494 EamA-like transporter family; Region: EamA; pfam00892 1114970007495 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1114970007496 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1114970007497 homodimer interface [polypeptide binding]; other site 1114970007498 substrate-cofactor binding pocket; other site 1114970007499 catalytic residue [active] 1114970007500 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1114970007501 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114970007502 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1114970007503 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1114970007504 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1114970007505 E3 interaction surface; other site 1114970007506 lipoyl attachment site [posttranslational modification]; other site 1114970007507 e3 binding domain; Region: E3_binding; pfam02817 1114970007508 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1114970007509 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1114970007510 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1114970007511 alpha subunit interface [polypeptide binding]; other site 1114970007512 TPP binding site [chemical binding]; other site 1114970007513 heterodimer interface [polypeptide binding]; other site 1114970007514 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1114970007515 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 1114970007516 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1114970007517 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1114970007518 tetramer interface [polypeptide binding]; other site 1114970007519 TPP-binding site [chemical binding]; other site 1114970007520 heterodimer interface [polypeptide binding]; other site 1114970007521 phosphorylation loop region [posttranslational modification] 1114970007522 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1114970007523 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114970007524 putative DNA binding site [nucleotide binding]; other site 1114970007525 putative Zn2+ binding site [ion binding]; other site 1114970007526 AsnC family; Region: AsnC_trans_reg; pfam01037 1114970007527 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 1114970007528 active site 1114970007529 catalytic residues [active] 1114970007530 DctM-like transporters; Region: DctM; pfam06808 1114970007531 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1114970007532 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1114970007533 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1114970007534 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1114970007535 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1114970007536 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1114970007537 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970007538 active site 1114970007539 outer membrane porin, OprD family; Region: OprD; pfam03573 1114970007540 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1114970007541 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114970007542 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1114970007543 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1114970007544 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 1114970007545 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 1114970007546 homodimer interface [polypeptide binding]; other site 1114970007547 active site 1114970007548 FMN binding site [chemical binding]; other site 1114970007549 substrate binding site [chemical binding]; other site 1114970007550 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1114970007551 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 1114970007552 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1114970007553 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114970007554 phenylhydantoinase; Validated; Region: PRK08323 1114970007555 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 1114970007556 tetramer interface [polypeptide binding]; other site 1114970007557 active site 1114970007558 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 1114970007559 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1114970007560 Na binding site [ion binding]; other site 1114970007561 putative substrate binding site [chemical binding]; other site 1114970007562 allantoate amidohydrolase; Reviewed; Region: PRK12893 1114970007563 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1114970007564 active site 1114970007565 metal binding site [ion binding]; metal-binding site 1114970007566 dimer interface [polypeptide binding]; other site 1114970007567 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1114970007568 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970007569 putative active site [active] 1114970007570 heme pocket [chemical binding]; other site 1114970007571 PAS domain S-box; Region: sensory_box; TIGR00229 1114970007572 PAS domain; Region: PAS; smart00091 1114970007573 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114970007574 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970007575 DNA binding residues [nucleotide binding] 1114970007576 dimerization interface [polypeptide binding]; other site 1114970007577 Protein of unknown function (DUF1652); Region: DUF1652; pfam07865 1114970007578 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114970007579 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970007580 dimerization interface [polypeptide binding]; other site 1114970007581 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970007582 dimer interface [polypeptide binding]; other site 1114970007583 phosphorylation site [posttranslational modification] 1114970007584 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970007585 ATP binding site [chemical binding]; other site 1114970007586 Mg2+ binding site [ion binding]; other site 1114970007587 G-X-G motif; other site 1114970007588 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114970007589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970007590 active site 1114970007591 phosphorylation site [posttranslational modification] 1114970007592 intermolecular recognition site; other site 1114970007593 dimerization interface [polypeptide binding]; other site 1114970007594 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970007595 DNA binding site [nucleotide binding] 1114970007596 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1114970007597 catalytic loop [active] 1114970007598 iron binding site [ion binding]; other site 1114970007599 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1114970007600 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1114970007601 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1114970007602 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1114970007603 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1114970007604 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1114970007605 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 1114970007606 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1114970007607 N-terminal domain interface [polypeptide binding]; other site 1114970007608 putative substrate binding pocket (H-site) [chemical binding]; other site 1114970007609 dimer interface [polypeptide binding]; other site 1114970007610 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1114970007611 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1114970007612 putative active site [active] 1114970007613 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1114970007614 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1114970007615 substrate binding site [chemical binding]; other site 1114970007616 ATP binding site [chemical binding]; other site 1114970007617 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 1114970007618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 1114970007619 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1114970007620 KduI/IolB family; Region: KduI; cl01508 1114970007621 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1114970007622 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1114970007623 tetrameric interface [polypeptide binding]; other site 1114970007624 NAD binding site [chemical binding]; other site 1114970007625 catalytic residues [active] 1114970007626 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 1114970007627 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1114970007628 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1114970007629 PYR/PP interface [polypeptide binding]; other site 1114970007630 dimer interface [polypeptide binding]; other site 1114970007631 TPP binding site [chemical binding]; other site 1114970007632 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1114970007633 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1114970007634 TPP-binding site; other site 1114970007635 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1114970007636 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1114970007637 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1114970007638 putative oxidoreductase; Provisional; Region: PRK11579 1114970007639 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1114970007640 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1114970007641 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1114970007642 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 1114970007643 putative ligand binding site [chemical binding]; other site 1114970007644 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1114970007645 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1114970007646 Walker A/P-loop; other site 1114970007647 ATP binding site [chemical binding]; other site 1114970007648 Q-loop/lid; other site 1114970007649 ABC transporter signature motif; other site 1114970007650 Walker B; other site 1114970007651 D-loop; other site 1114970007652 H-loop/switch region; other site 1114970007653 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1114970007654 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1114970007655 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1114970007656 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1114970007657 TM-ABC transporter signature motif; other site 1114970007658 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 1114970007659 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970007660 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970007661 dimer interface [polypeptide binding]; other site 1114970007662 putative CheW interface [polypeptide binding]; other site 1114970007663 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 1114970007664 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1114970007665 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1114970007666 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 1114970007667 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671 1114970007668 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 1114970007669 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1114970007670 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 1114970007671 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1114970007672 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 1114970007673 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 1114970007674 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1114970007675 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1114970007676 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1114970007677 monovalent cation:proton antiporter; Region: 2a6301s02; TIGR00943 1114970007678 Possible frameshift 1114970007679 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1114970007680 EamA-like transporter family; Region: EamA; pfam00892 1114970007681 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114970007682 non-specific DNA binding site [nucleotide binding]; other site 1114970007683 salt bridge; other site 1114970007684 sequence-specific DNA binding site [nucleotide binding]; other site 1114970007685 Cupin domain; Region: Cupin_2; pfam07883 1114970007686 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1114970007687 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1114970007688 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1114970007689 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1114970007690 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1114970007691 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1114970007692 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 1114970007693 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 1114970007694 Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255 1114970007695 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1114970007696 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1114970007697 short chain dehydrogenase; Provisional; Region: PRK07035 1114970007698 classical (c) SDRs; Region: SDR_c; cd05233 1114970007699 NAD(P) binding site [chemical binding]; other site 1114970007700 active site 1114970007701 Phosphotransferase enzyme family; Region: APH; pfam01636 1114970007702 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1114970007703 putative active site [active] 1114970007704 putative substrate binding site [chemical binding]; other site 1114970007705 ATP binding site [chemical binding]; other site 1114970007706 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 1114970007707 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1114970007708 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1114970007709 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1114970007710 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1114970007711 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 1114970007712 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 1114970007713 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1114970007714 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970007715 Walker A motif; other site 1114970007716 ATP binding site [chemical binding]; other site 1114970007717 Walker B motif; other site 1114970007718 arginine finger; other site 1114970007719 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970007720 Walker A motif; other site 1114970007721 ATP binding site [chemical binding]; other site 1114970007722 Walker B motif; other site 1114970007723 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 1114970007724 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1114970007725 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1114970007726 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 1114970007727 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 1114970007728 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 1114970007729 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1114970007730 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 1114970007731 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 1114970007732 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1114970007733 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 1114970007734 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 1114970007735 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 1114970007736 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1114970007737 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 1114970007738 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1114970007739 putative ligand binding site [chemical binding]; other site 1114970007740 NAD binding site [chemical binding]; other site 1114970007741 catalytic site [active] 1114970007742 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1114970007743 serine transporter; Region: stp; TIGR00814 1114970007744 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1114970007745 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1114970007746 substrate binding site [chemical binding]; other site 1114970007747 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1114970007748 substrate binding site [chemical binding]; other site 1114970007749 ligand binding site [chemical binding]; other site 1114970007750 Predicted Fe-S protein [General function prediction only]; Region: COG3313 1114970007751 universal stress protein UspE; Provisional; Region: PRK11175 1114970007752 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1114970007753 Ligand Binding Site [chemical binding]; other site 1114970007754 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1114970007755 Ligand Binding Site [chemical binding]; other site 1114970007756 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 1114970007757 active site 1114970007758 dinuclear metal binding site [ion binding]; other site 1114970007759 dimerization interface [polypeptide binding]; other site 1114970007760 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 1114970007761 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970007762 active site 1114970007763 phosphorylation site [posttranslational modification] 1114970007764 intermolecular recognition site; other site 1114970007765 dimerization interface [polypeptide binding]; other site 1114970007766 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970007767 DNA binding site [nucleotide binding] 1114970007768 sensor protein RstB; Provisional; Region: PRK10604 1114970007769 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970007770 dimerization interface [polypeptide binding]; other site 1114970007771 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970007772 dimer interface [polypeptide binding]; other site 1114970007773 phosphorylation site [posttranslational modification] 1114970007774 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970007775 ATP binding site [chemical binding]; other site 1114970007776 Mg2+ binding site [ion binding]; other site 1114970007777 G-X-G motif; other site 1114970007778 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1114970007779 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1114970007780 DNA-3-methyladenine glycosylase II frameshift 1114970007781 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1114970007782 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 1114970007783 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1114970007784 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1114970007785 DNA binding site [nucleotide binding] 1114970007786 active site 1114970007787 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1114970007788 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1114970007789 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1114970007790 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1114970007791 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1114970007792 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970007793 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970007794 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1114970007795 GAF domain; Region: GAF; pfam01590 1114970007796 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114970007797 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970007798 metal binding site [ion binding]; metal-binding site 1114970007799 active site 1114970007800 I-site; other site 1114970007801 Possible frameshift 1114970007802 Nitrate and nitrite sensing; Region: NIT; pfam08376 1114970007803 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970007804 dimerization interface [polypeptide binding]; other site 1114970007805 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970007806 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970007807 dimer interface [polypeptide binding]; other site 1114970007808 putative CheW interface [polypeptide binding]; other site 1114970007809 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1114970007810 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114970007811 catalytic residue [active] 1114970007812 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1114970007813 putative phosphate binding site [ion binding]; other site 1114970007814 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1114970007815 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1114970007816 Walker A/P-loop; other site 1114970007817 ATP binding site [chemical binding]; other site 1114970007818 Q-loop/lid; other site 1114970007819 ABC transporter signature motif; other site 1114970007820 Walker B; other site 1114970007821 D-loop; other site 1114970007822 H-loop/switch region; other site 1114970007823 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1114970007824 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114970007825 ABC-ATPase subunit interface; other site 1114970007826 dimer interface [polypeptide binding]; other site 1114970007827 putative PBP binding regions; other site 1114970007828 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 1114970007829 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 1114970007830 putative ligand binding residues [chemical binding]; other site 1114970007831 Secretin and TonB N terminus short domain; Region: STN; smart00965 1114970007832 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1114970007833 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970007834 N-terminal plug; other site 1114970007835 ligand-binding site [chemical binding]; other site 1114970007836 fec operon regulator FecR; Reviewed; Region: PRK09774 1114970007837 FecR protein; Region: FecR; pfam04773 1114970007838 RNA polymerase sigma factor; Provisional; Region: PRK12528 1114970007839 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970007840 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114970007841 DNA binding residues [nucleotide binding] 1114970007842 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970007843 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970007844 putative substrate translocation pore; other site 1114970007845 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1114970007846 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970007847 N-terminal plug; other site 1114970007848 ligand-binding site [chemical binding]; other site 1114970007849 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 1114970007850 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970007851 D-galactonate transporter; Region: 2A0114; TIGR00893 1114970007852 putative substrate translocation pore; other site 1114970007853 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1114970007854 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1114970007855 malonyl-CoA binding site [chemical binding]; other site 1114970007856 dimer interface [polypeptide binding]; other site 1114970007857 active site 1114970007858 product binding site; other site 1114970007859 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1114970007860 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1114970007861 DUF35 OB-fold domain; Region: DUF35; pfam01796 1114970007862 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 1114970007863 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1114970007864 active site 1114970007865 hypothetical protein; Provisional; Region: PRK04262 1114970007866 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1114970007867 dimer interface [polypeptide binding]; other site 1114970007868 active site 1114970007869 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970007870 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114970007871 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1114970007872 Predicted membrane protein [Function unknown]; Region: COG2259 1114970007873 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1114970007874 Salmonella virulence plasmid 28.1kDa A protein; Region: VRP1; pfam03538 1114970007875 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 1114970007876 putative dehydratase, YjhG/YagF family; Region: yjhG_yagF; TIGR03432 1114970007877 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 1114970007878 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1114970007879 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1114970007880 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970007881 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 1114970007882 putative dimerization interface [polypeptide binding]; other site 1114970007883 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970007884 D-galactonate transporter; Region: 2A0114; TIGR00893 1114970007885 putative substrate translocation pore; other site 1114970007886 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1114970007887 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 1114970007888 NAD binding site [chemical binding]; other site 1114970007889 homotetramer interface [polypeptide binding]; other site 1114970007890 homodimer interface [polypeptide binding]; other site 1114970007891 active site 1114970007892 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1114970007893 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1114970007894 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1114970007895 Protein export membrane protein; Region: SecD_SecF; cl14618 1114970007896 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 1114970007897 HlyD family secretion protein; Region: HlyD_3; pfam13437 1114970007898 Cache domain; Region: Cache_1; pfam02743 1114970007899 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970007900 dimerization interface [polypeptide binding]; other site 1114970007901 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970007902 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970007903 dimer interface [polypeptide binding]; other site 1114970007904 putative CheW interface [polypeptide binding]; other site 1114970007905 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1114970007906 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970007907 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 1114970007908 NAD(P) binding site [chemical binding]; other site 1114970007909 catalytic residues [active] 1114970007910 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114970007911 hypothetical protein; Provisional; Region: PRK07481 1114970007912 inhibitor-cofactor binding pocket; inhibition site 1114970007913 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970007914 catalytic residue [active] 1114970007915 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 1114970007916 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1114970007917 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1114970007918 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1114970007919 Bacterial transcriptional regulator; Region: IclR; pfam01614 1114970007920 hypothetical protein; Validated; Region: PRK07586 1114970007921 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1114970007922 PYR/PP interface [polypeptide binding]; other site 1114970007923 dimer interface [polypeptide binding]; other site 1114970007924 TPP binding site [chemical binding]; other site 1114970007925 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1114970007926 TPP-binding site [chemical binding]; other site 1114970007927 dimer interface [polypeptide binding]; other site 1114970007928 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1114970007929 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970007930 NAD(P) binding site [chemical binding]; other site 1114970007931 catalytic residues [active] 1114970007932 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1114970007933 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970007934 NAD(P) binding site [chemical binding]; other site 1114970007935 active site 1114970007936 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1114970007937 Ycf48-like protein; Provisional; Region: PRK13684 1114970007938 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1114970007939 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114970007940 active site 1114970007941 metal binding site [ion binding]; metal-binding site 1114970007942 Amino acid synthesis; Region: AA_synth; pfam06684 1114970007943 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1114970007944 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1114970007945 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 1114970007946 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1114970007947 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1114970007948 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114970007949 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970007950 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1114970007951 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970007952 DNA-binding site [nucleotide binding]; DNA binding site 1114970007953 FCD domain; Region: FCD; pfam07729 1114970007954 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970007955 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970007956 substrate binding pocket [chemical binding]; other site 1114970007957 membrane-bound complex binding site; other site 1114970007958 hinge residues; other site 1114970007959 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114970007960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970007961 dimer interface [polypeptide binding]; other site 1114970007962 conserved gate region; other site 1114970007963 putative PBP binding loops; other site 1114970007964 ABC-ATPase subunit interface; other site 1114970007965 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1114970007966 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1114970007967 Walker A/P-loop; other site 1114970007968 ATP binding site [chemical binding]; other site 1114970007969 Q-loop/lid; other site 1114970007970 ABC transporter signature motif; other site 1114970007971 Walker B; other site 1114970007972 D-loop; other site 1114970007973 H-loop/switch region; other site 1114970007974 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114970007975 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1114970007976 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1114970007977 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 1114970007978 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1114970007979 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1114970007980 putative NAD(P) binding site [chemical binding]; other site 1114970007981 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1114970007982 classical (c) SDRs; Region: SDR_c; cd05233 1114970007983 NAD(P) binding site [chemical binding]; other site 1114970007984 active site 1114970007985 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1114970007986 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1114970007987 FMN binding site [chemical binding]; other site 1114970007988 active site 1114970007989 substrate binding site [chemical binding]; other site 1114970007990 catalytic residue [active] 1114970007991 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114970007992 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114970007993 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114970007994 DNA binding site [nucleotide binding] 1114970007995 domain linker motif; other site 1114970007996 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 1114970007997 putative dimerization interface [polypeptide binding]; other site 1114970007998 putative ligand binding site [chemical binding]; other site 1114970007999 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1114970008000 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1114970008001 substrate binding [chemical binding]; other site 1114970008002 active site 1114970008003 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1114970008004 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1114970008005 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1114970008006 Walker A/P-loop; other site 1114970008007 ATP binding site [chemical binding]; other site 1114970008008 Q-loop/lid; other site 1114970008009 ABC transporter signature motif; other site 1114970008010 Walker B; other site 1114970008011 D-loop; other site 1114970008012 H-loop/switch region; other site 1114970008013 TOBE domain; Region: TOBE_2; pfam08402 1114970008014 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1114970008015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970008016 dimer interface [polypeptide binding]; other site 1114970008017 putative PBP binding loops; other site 1114970008018 ABC-ATPase subunit interface; other site 1114970008019 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1114970008020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970008021 dimer interface [polypeptide binding]; other site 1114970008022 conserved gate region; other site 1114970008023 putative PBP binding loops; other site 1114970008024 ABC-ATPase subunit interface; other site 1114970008025 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1114970008026 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1114970008027 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1114970008028 trimer interface; other site 1114970008029 sugar binding site [chemical binding]; other site 1114970008030 Trehalase; Region: Trehalase; cl17346 1114970008031 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 1114970008032 PAS domain; Region: PAS; smart00091 1114970008033 PAS fold; Region: PAS_4; pfam08448 1114970008034 putative active site [active] 1114970008035 heme pocket [chemical binding]; other site 1114970008036 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114970008037 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970008038 metal binding site [ion binding]; metal-binding site 1114970008039 active site 1114970008040 I-site; other site 1114970008041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970008042 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970008043 active site 1114970008044 phosphorylation site [posttranslational modification] 1114970008045 intermolecular recognition site; other site 1114970008046 dimerization interface [polypeptide binding]; other site 1114970008047 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 1114970008048 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114970008049 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970008050 metal binding site [ion binding]; metal-binding site 1114970008051 active site 1114970008052 I-site; other site 1114970008053 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970008054 PBP superfamily domain; Region: PBP_like_2; cl17296 1114970008055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970008056 ATP binding site [chemical binding]; other site 1114970008057 Mg2+ binding site [ion binding]; other site 1114970008058 G-X-G motif; other site 1114970008059 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114970008060 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970008061 catalytic residue [active] 1114970008062 Uncharacterized conserved protein [Function unknown]; Region: COG3287 1114970008063 FIST N domain; Region: FIST; smart00897 1114970008064 FIST C domain; Region: FIST_C; pfam10442 1114970008065 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970008066 dimer interface [polypeptide binding]; other site 1114970008067 putative CheW interface [polypeptide binding]; other site 1114970008068 putative S-transferase; Provisional; Region: PRK11752 1114970008069 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1114970008070 C-terminal domain interface [polypeptide binding]; other site 1114970008071 GSH binding site (G-site) [chemical binding]; other site 1114970008072 dimer interface [polypeptide binding]; other site 1114970008073 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 1114970008074 dimer interface [polypeptide binding]; other site 1114970008075 N-terminal domain interface [polypeptide binding]; other site 1114970008076 active site 1114970008077 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 1114970008078 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114970008079 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970008080 metal binding site [ion binding]; metal-binding site 1114970008081 active site 1114970008082 I-site; other site 1114970008083 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970008084 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970008085 substrate binding pocket [chemical binding]; other site 1114970008086 membrane-bound complex binding site; other site 1114970008087 hinge residues; other site 1114970008088 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114970008089 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1114970008090 active site 1114970008091 catalytic tetrad [active] 1114970008092 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970008093 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970008094 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1114970008095 putative effector binding pocket; other site 1114970008096 putative dimerization interface [polypeptide binding]; other site 1114970008097 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1114970008098 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970008099 NAD(P) binding site [chemical binding]; other site 1114970008100 catalytic residues [active] 1114970008101 PAS fold; Region: PAS_3; pfam08447 1114970008102 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970008103 putative active site [active] 1114970008104 heme pocket [chemical binding]; other site 1114970008105 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970008106 dimer interface [polypeptide binding]; other site 1114970008107 putative CheW interface [polypeptide binding]; other site 1114970008108 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 1114970008109 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1114970008110 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 1114970008111 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 1114970008112 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970008113 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1114970008114 classical (c) SDRs; Region: SDR_c; cd05233 1114970008115 NAD(P) binding site [chemical binding]; other site 1114970008116 active site 1114970008117 classical (c) SDRs; Region: SDR_c; cd05233 1114970008118 short chain dehydrogenase; Provisional; Region: PRK07478 1114970008119 NAD(P) binding site [chemical binding]; other site 1114970008120 active site 1114970008121 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 1114970008122 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114970008123 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970008124 DNA binding residues [nucleotide binding] 1114970008125 dimerization interface [polypeptide binding]; other site 1114970008126 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 1114970008127 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1114970008128 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1114970008129 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 1114970008130 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1114970008131 Flavin binding site [chemical binding]; other site 1114970008132 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1114970008133 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1114970008134 HemN C-terminal domain; Region: HemN_C; pfam06969 1114970008135 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 1114970008136 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114970008137 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Region: HpaI; TIGR02311 1114970008138 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 1114970008139 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1114970008140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970008141 putative substrate translocation pore; other site 1114970008142 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 1114970008143 putative substrate binding pocket [chemical binding]; other site 1114970008144 trimer interface [polypeptide binding]; other site 1114970008145 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 1114970008146 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1114970008147 putative active site [active] 1114970008148 putative metal binding site [ion binding]; other site 1114970008149 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 1114970008150 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1114970008151 NAD binding site [chemical binding]; other site 1114970008152 catalytic residues [active] 1114970008153 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 1114970008154 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1114970008155 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1114970008156 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1114970008157 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 1114970008158 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1114970008159 Cupin; Region: Cupin_6; pfam12852 1114970008160 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970008161 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 1114970008162 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114970008163 hypothetical protein; Provisional; Region: PRK09936 1114970008164 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 1114970008165 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 1114970008166 active site 1114970008167 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1114970008168 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1114970008169 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1114970008170 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1114970008171 active site 1114970008172 homodimer interface [polypeptide binding]; other site 1114970008173 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1114970008174 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1114970008175 DctM-like transporters; Region: DctM; pfam06808 1114970008176 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1114970008177 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1114970008178 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970008179 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970008180 substrate binding pocket [chemical binding]; other site 1114970008181 membrane-bound complex binding site; other site 1114970008182 hinge residues; other site 1114970008183 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970008184 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114970008185 major facilitator superfamily transporter; Provisional; Region: PRK05122 1114970008186 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970008187 putative substrate translocation pore; other site 1114970008188 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 1114970008189 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1114970008190 putative NAD(P) binding site [chemical binding]; other site 1114970008191 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114970008192 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970008193 active site 1114970008194 phosphorylation site [posttranslational modification] 1114970008195 intermolecular recognition site; other site 1114970008196 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970008197 DNA binding residues [nucleotide binding] 1114970008198 dimerization interface [polypeptide binding]; other site 1114970008199 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 1114970008200 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1114970008201 Histidine kinase; Region: HisKA_3; pfam07730 1114970008202 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970008203 ATP binding site [chemical binding]; other site 1114970008204 Mg2+ binding site [ion binding]; other site 1114970008205 G-X-G motif; other site 1114970008206 carbon starvation protein A; Provisional; Region: PRK15015 1114970008207 Carbon starvation protein CstA; Region: CstA; pfam02554 1114970008208 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1114970008209 Uncharacterized small protein [Function unknown]; Region: COG2879 1114970008210 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1114970008211 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1114970008212 iron-sulfur cluster [ion binding]; other site 1114970008213 [2Fe-2S] cluster binding site [ion binding]; other site 1114970008214 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1114970008215 hydrophobic ligand binding site; other site 1114970008216 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 1114970008217 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970008218 NAD binding site [chemical binding]; other site 1114970008219 catalytic residues [active] 1114970008220 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1114970008221 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1114970008222 active site 1114970008223 iron coordination sites [ion binding]; other site 1114970008224 substrate binding pocket [chemical binding]; other site 1114970008225 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114970008226 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970008227 DNA binding residues [nucleotide binding] 1114970008228 dimerization interface [polypeptide binding]; other site 1114970008229 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970008230 putative substrate translocation pore; other site 1114970008231 choline dehydrogenase; Validated; Region: PRK02106 1114970008232 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1114970008233 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 1114970008234 SnoaL-like domain; Region: SnoaL_4; pfam13577 1114970008235 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1114970008236 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1114970008237 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1114970008238 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1114970008239 SnoaL-like domain; Region: SnoaL_4; pfam13577 1114970008240 SnoaL-like domain; Region: SnoaL_4; pfam13577 1114970008241 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1114970008242 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1114970008243 NADP binding site [chemical binding]; other site 1114970008244 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970008245 dimerization interface [polypeptide binding]; other site 1114970008246 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970008247 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970008248 dimer interface [polypeptide binding]; other site 1114970008249 putative CheW interface [polypeptide binding]; other site 1114970008250 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 1114970008251 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1114970008252 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1114970008253 Na binding site [ion binding]; other site 1114970008254 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1114970008255 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970008256 N-terminal plug; other site 1114970008257 ligand-binding site [chemical binding]; other site 1114970008258 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1114970008259 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1114970008260 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1114970008261 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1114970008262 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114970008263 Walker A/P-loop; other site 1114970008264 ATP binding site [chemical binding]; other site 1114970008265 Q-loop/lid; other site 1114970008266 ABC transporter signature motif; other site 1114970008267 Walker B; other site 1114970008268 D-loop; other site 1114970008269 H-loop/switch region; other site 1114970008270 TOBE domain; Region: TOBE_2; pfam08402 1114970008271 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1114970008272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970008273 dimer interface [polypeptide binding]; other site 1114970008274 conserved gate region; other site 1114970008275 putative PBP binding loops; other site 1114970008276 ABC-ATPase subunit interface; other site 1114970008277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970008278 dimer interface [polypeptide binding]; other site 1114970008279 conserved gate region; other site 1114970008280 putative PBP binding loops; other site 1114970008281 ABC-ATPase subunit interface; other site 1114970008282 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1114970008283 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1114970008284 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK12485 1114970008285 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1114970008286 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 1114970008287 Uncharacterized conserved protein [Function unknown]; Region: COG5470 1114970008288 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 1114970008289 nudix motif; other site 1114970008290 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1114970008291 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970008292 DNA-binding site [nucleotide binding]; DNA binding site 1114970008293 FCD domain; Region: FCD; pfam07729 1114970008294 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1114970008295 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1114970008296 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970008297 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 1114970008298 NAD(P) binding site [chemical binding]; other site 1114970008299 catalytic residues [active] 1114970008300 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1114970008301 Amino acid synthesis; Region: AA_synth; pfam06684 1114970008302 Helix-turn-helix domain; Region: HTH_18; pfam12833 1114970008303 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1114970008304 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970008305 N-terminal plug; other site 1114970008306 ligand-binding site [chemical binding]; other site 1114970008307 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1114970008308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970008309 S-adenosylmethionine binding site [chemical binding]; other site 1114970008310 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 1114970008311 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1114970008312 dimer interface [polypeptide binding]; other site 1114970008313 PYR/PP interface [polypeptide binding]; other site 1114970008314 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1114970008315 Predicted dehydrogenase [General function prediction only]; Region: COG5322 1114970008316 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1114970008317 NAD(P) binding pocket [chemical binding]; other site 1114970008318 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 1114970008319 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114970008320 inhibitor-cofactor binding pocket; inhibition site 1114970008321 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970008322 catalytic residue [active] 1114970008323 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1114970008324 ATP binding site [chemical binding]; other site 1114970008325 substrate interface [chemical binding]; other site 1114970008326 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1114970008327 active site residue [active] 1114970008328 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 1114970008329 MPN+ (JAMM) motif; other site 1114970008330 Zinc-binding site [ion binding]; other site 1114970008331 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1114970008332 MoaE interaction surface [polypeptide binding]; other site 1114970008333 thiocarboxylated glycine; other site 1114970008334 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1114970008335 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1114970008336 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1114970008337 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1114970008338 acyl-activating enzyme (AAE) consensus motif; other site 1114970008339 AMP binding site [chemical binding]; other site 1114970008340 active site 1114970008341 CoA binding site [chemical binding]; other site 1114970008342 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1114970008343 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1114970008344 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1114970008345 active site 1114970008346 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970008347 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970008348 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1114970008349 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1114970008350 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1114970008351 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1114970008352 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1114970008353 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1114970008354 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1114970008355 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1114970008356 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1114970008357 Surface antigen; Region: Bac_surface_Ag; pfam01103 1114970008358 Domain of unknown function (DUF2341); Region: DUF2341; pfam10102 1114970008359 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1114970008360 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1114970008361 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1114970008362 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1114970008363 TonB C terminal; Region: TonB_2; pfam13103 1114970008364 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1114970008365 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 1114970008366 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1114970008367 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970008368 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970008369 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1114970008370 dimerization interface [polypeptide binding]; other site 1114970008371 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1114970008372 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970008373 Coenzyme A binding pocket [chemical binding]; other site 1114970008374 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 1114970008375 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1114970008376 dimer interface [polypeptide binding]; other site 1114970008377 catalytic triad [active] 1114970008378 peroxidatic and resolving cysteines [active] 1114970008379 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 1114970008380 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1114970008381 HlyD family secretion protein; Region: HlyD_3; pfam13437 1114970008382 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1114970008383 Protein export membrane protein; Region: SecD_SecF; cl14618 1114970008384 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 1114970008385 Protein export membrane protein; Region: SecD_SecF; cl14618 1114970008386 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1114970008387 enoyl-CoA hydratase; Provisional; Region: PRK06142 1114970008388 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114970008389 substrate binding site [chemical binding]; other site 1114970008390 oxyanion hole (OAH) forming residues; other site 1114970008391 trimer interface [polypeptide binding]; other site 1114970008392 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1114970008393 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1114970008394 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1114970008395 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1114970008396 putative NADH binding site [chemical binding]; other site 1114970008397 putative active site [active] 1114970008398 nudix motif; other site 1114970008399 putative metal binding site [ion binding]; other site 1114970008400 hypothetical protein; Provisional; Region: PRK10621 1114970008401 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1114970008402 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667 1114970008403 nudix motif; other site 1114970008404 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1114970008405 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1114970008406 NodB motif; other site 1114970008407 active site 1114970008408 catalytic site [active] 1114970008409 metal binding site [ion binding]; metal-binding site 1114970008410 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114970008411 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970008412 ATP binding site [chemical binding]; other site 1114970008413 G-X-G motif; other site 1114970008414 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1114970008415 SPFH domain / Band 7 family; Region: Band_7; pfam01145 1114970008416 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1114970008417 YccA-like proteins; Region: YccA_like; cd10433 1114970008418 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 1114970008419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970008420 putative substrate translocation pore; other site 1114970008421 outer membrane porin, OprD family; Region: OprD; pfam03573 1114970008422 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114970008423 MarR family; Region: MarR_2; pfam12802 1114970008424 p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120 1114970008425 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114970008426 substrate binding site [chemical binding]; other site 1114970008427 oxyanion hole (OAH) forming residues; other site 1114970008428 trimer interface [polypeptide binding]; other site 1114970008429 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970008430 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 1114970008431 NAD(P) binding site [chemical binding]; other site 1114970008432 catalytic residues [active] 1114970008433 feruloyl-CoA synthase; Reviewed; Region: PRK08180 1114970008434 Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921 1114970008435 acyl-activating enzyme (AAE) consensus motif; other site 1114970008436 putative AMP binding site [chemical binding]; other site 1114970008437 putative active site [active] 1114970008438 putative CoA binding site [chemical binding]; other site 1114970008439 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 1114970008440 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970008441 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970008442 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 1114970008443 putative substrate binding pocket [chemical binding]; other site 1114970008444 putative dimerization interface [polypeptide binding]; other site 1114970008445 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 1114970008446 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1114970008447 putative active site [active] 1114970008448 catalytic triad [active] 1114970008449 putative dimer interface [polypeptide binding]; other site 1114970008450 Water Stress and Hypersensitive response; Region: WHy; smart00769 1114970008451 HTH domain; Region: HTH_11; pfam08279 1114970008452 Predicted transcriptional regulator [Transcription]; Region: COG2378 1114970008453 WYL domain; Region: WYL; pfam13280 1114970008454 SnoaL-like domain; Region: SnoaL_2; pfam12680 1114970008455 Predicted ATPase [General function prediction only]; Region: COG1485 1114970008456 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1114970008457 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970008458 Coenzyme A binding pocket [chemical binding]; other site 1114970008459 hypothetical protein; Provisional; Region: PRK10649 1114970008460 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1114970008461 Sulfatase; Region: Sulfatase; pfam00884 1114970008462 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1114970008463 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 1114970008464 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 1114970008465 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1114970008466 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1114970008467 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1114970008468 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114970008469 active site 1114970008470 motif I; other site 1114970008471 motif II; other site 1114970008472 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1114970008473 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 1114970008474 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1114970008475 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1114970008476 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1114970008477 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1114970008478 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970008479 Walker A motif; other site 1114970008480 ATP binding site [chemical binding]; other site 1114970008481 Walker B motif; other site 1114970008482 arginine finger; other site 1114970008483 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1114970008484 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 1114970008485 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 1114970008486 putative active site [active] 1114970008487 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1114970008488 AAA domain; Region: AAA_28; pfam13521 1114970008489 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1114970008490 Cache domain; Region: Cache_2; pfam08269 1114970008491 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970008492 dimerization interface [polypeptide binding]; other site 1114970008493 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970008494 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970008495 dimer interface [polypeptide binding]; other site 1114970008496 putative CheW interface [polypeptide binding]; other site 1114970008497 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1114970008498 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 1114970008499 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1114970008500 LysR family transcriptional regulator; Provisional; Region: PRK14997 1114970008501 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970008502 dimerization interface [polypeptide binding]; other site 1114970008503 azoreductase; Reviewed; Region: PRK00170 1114970008504 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1114970008505 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1114970008506 major facilitator superfamily transporter; Provisional; Region: PRK05122 1114970008507 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1114970008508 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114970008509 Walker A/P-loop; other site 1114970008510 ATP binding site [chemical binding]; other site 1114970008511 Q-loop/lid; other site 1114970008512 ABC transporter signature motif; other site 1114970008513 Walker B; other site 1114970008514 D-loop; other site 1114970008515 H-loop/switch region; other site 1114970008516 ABC transporter; Region: ABC_tran_2; pfam12848 1114970008517 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1114970008518 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 1114970008519 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1114970008520 active site 1114970008521 DNA binding site [nucleotide binding] 1114970008522 DNA ligase D; Region: NHEJ_ligase_prk; TIGR02776 1114970008523 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1114970008524 DNA binding site [nucleotide binding] 1114970008525 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 1114970008526 nucleotide binding site [chemical binding]; other site 1114970008527 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1114970008528 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1114970008529 putative DNA binding site [nucleotide binding]; other site 1114970008530 putative homodimer interface [polypeptide binding]; other site 1114970008531 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1114970008532 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1114970008533 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1114970008534 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1114970008535 tetramer interface [polypeptide binding]; other site 1114970008536 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970008537 catalytic residue [active] 1114970008538 Protein of unknown function (DUF1652); Region: DUF1652; pfam07865 1114970008539 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1114970008540 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1114970008541 putative substrate binding site [chemical binding]; other site 1114970008542 putative ATP binding site [chemical binding]; other site 1114970008543 D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809 1114970008544 N- and C-terminal domain interface [polypeptide binding]; other site 1114970008545 D-xylulose kinase; Region: XylB; TIGR01312 1114970008546 active site 1114970008547 MgATP binding site [chemical binding]; other site 1114970008548 catalytic site [active] 1114970008549 metal binding site [ion binding]; metal-binding site 1114970008550 xylulose binding site [chemical binding]; other site 1114970008551 putative homodimer interface [polypeptide binding]; other site 1114970008552 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1114970008553 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1114970008554 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1114970008555 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1114970008556 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1114970008557 Walker A/P-loop; other site 1114970008558 ATP binding site [chemical binding]; other site 1114970008559 Q-loop/lid; other site 1114970008560 ABC transporter signature motif; other site 1114970008561 Walker B; other site 1114970008562 D-loop; other site 1114970008563 H-loop/switch region; other site 1114970008564 TOBE domain; Region: TOBE_2; pfam08402 1114970008565 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1114970008566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970008567 dimer interface [polypeptide binding]; other site 1114970008568 conserved gate region; other site 1114970008569 putative PBP binding loops; other site 1114970008570 ABC-ATPase subunit interface; other site 1114970008571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970008572 putative PBP binding loops; other site 1114970008573 ABC-ATPase subunit interface; other site 1114970008574 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1114970008575 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1114970008576 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1114970008577 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1114970008578 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970008579 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970008580 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 1114970008581 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1114970008582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970008583 active site 1114970008584 phosphorylation site [posttranslational modification] 1114970008585 intermolecular recognition site; other site 1114970008586 dimerization interface [polypeptide binding]; other site 1114970008587 CHASE3 domain; Region: CHASE3; pfam05227 1114970008588 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1114970008589 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1114970008590 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970008591 dimer interface [polypeptide binding]; other site 1114970008592 phosphorylation site [posttranslational modification] 1114970008593 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970008594 ATP binding site [chemical binding]; other site 1114970008595 Mg2+ binding site [ion binding]; other site 1114970008596 G-X-G motif; other site 1114970008597 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970008598 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970008599 active site 1114970008600 phosphorylation site [posttranslational modification] 1114970008601 intermolecular recognition site; other site 1114970008602 dimerization interface [polypeptide binding]; other site 1114970008603 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1114970008604 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970008605 active site 1114970008606 phosphorylation site [posttranslational modification] 1114970008607 intermolecular recognition site; other site 1114970008608 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1114970008609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970008610 active site 1114970008611 phosphorylation site [posttranslational modification] 1114970008612 intermolecular recognition site; other site 1114970008613 dimerization interface [polypeptide binding]; other site 1114970008614 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1114970008615 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1114970008616 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1114970008617 CheB methylesterase; Region: CheB_methylest; pfam01339 1114970008618 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970008619 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970008620 active site 1114970008621 phosphorylation site [posttranslational modification] 1114970008622 intermolecular recognition site; other site 1114970008623 dimerization interface [polypeptide binding]; other site 1114970008624 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114970008625 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970008626 dimer interface [polypeptide binding]; other site 1114970008627 phosphorylation site [posttranslational modification] 1114970008628 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970008629 ATP binding site [chemical binding]; other site 1114970008630 Mg2+ binding site [ion binding]; other site 1114970008631 G-X-G motif; other site 1114970008632 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970008633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970008634 active site 1114970008635 phosphorylation site [posttranslational modification] 1114970008636 intermolecular recognition site; other site 1114970008637 dimerization interface [polypeptide binding]; other site 1114970008638 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1114970008639 dimer interface [polypeptide binding]; other site 1114970008640 phosphorylation site [posttranslational modification] 1114970008641 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970008642 ATP binding site [chemical binding]; other site 1114970008643 Mg2+ binding site [ion binding]; other site 1114970008644 G-X-G motif; other site 1114970008645 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1114970008646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970008647 active site 1114970008648 phosphorylation site [posttranslational modification] 1114970008649 intermolecular recognition site; other site 1114970008650 dimerization interface [polypeptide binding]; other site 1114970008651 circadian clock protein KaiC; Reviewed; Region: PRK09302 1114970008652 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1114970008653 Walker A motif; other site 1114970008654 ATP binding site [chemical binding]; other site 1114970008655 Walker B motif; other site 1114970008656 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1114970008657 Walker A motif; other site 1114970008658 ATP binding site [chemical binding]; other site 1114970008659 Walker B motif; other site 1114970008660 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1114970008661 TPR motif; other site 1114970008662 binding surface 1114970008663 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1114970008664 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 1114970008665 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1114970008666 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1114970008667 HlyD family secretion protein; Region: HlyD_3; pfam13437 1114970008668 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970008669 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1114970008670 substrate binding pocket [chemical binding]; other site 1114970008671 membrane-bound complex binding site; other site 1114970008672 hinge residues; other site 1114970008673 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970008674 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970008675 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 1114970008676 putative dimerization interface [polypeptide binding]; other site 1114970008677 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 1114970008678 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114970008679 putative metal binding site [ion binding]; other site 1114970008680 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970008681 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114970008682 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1114970008683 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970008684 NAD(P) binding site [chemical binding]; other site 1114970008685 active site 1114970008686 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1114970008687 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1114970008688 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1114970008689 HlyD family secretion protein; Region: HlyD_3; pfam13437 1114970008690 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1114970008691 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 1114970008692 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1114970008693 dimer interface [polypeptide binding]; other site 1114970008694 active site 1114970008695 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 1114970008696 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1114970008697 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 1114970008698 Walker A/P-loop; other site 1114970008699 ATP binding site [chemical binding]; other site 1114970008700 Q-loop/lid; other site 1114970008701 ABC transporter signature motif; other site 1114970008702 Walker B; other site 1114970008703 D-loop; other site 1114970008704 H-loop/switch region; other site 1114970008705 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1114970008706 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1114970008707 HlyD family secretion protein; Region: HlyD_3; pfam13437 1114970008708 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 1114970008709 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 1114970008710 active site 1114970008711 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1114970008712 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1114970008713 NADP binding site [chemical binding]; other site 1114970008714 dimer interface [polypeptide binding]; other site 1114970008715 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1114970008716 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1114970008717 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970008718 NAD(P) binding site [chemical binding]; other site 1114970008719 catalytic residues [active] 1114970008720 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1114970008721 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114970008722 inhibitor-cofactor binding pocket; inhibition site 1114970008723 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970008724 catalytic residue [active] 1114970008725 Helix-turn-helix domain; Region: HTH_18; pfam12833 1114970008726 Amino acid permease; Region: AA_permease; pfam00324 1114970008727 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1114970008728 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 1114970008729 universal stress protein UspE; Provisional; Region: PRK11175 1114970008730 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1114970008731 Ligand Binding Site [chemical binding]; other site 1114970008732 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1114970008733 Ligand Binding Site [chemical binding]; other site 1114970008734 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114970008735 active site 1114970008736 Possible frameshift 1114970008737 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114970008738 non-specific DNA binding site [nucleotide binding]; other site 1114970008739 salt bridge; other site 1114970008740 sequence-specific DNA binding site [nucleotide binding]; other site 1114970008741 HipA N-terminal domain; Region: Couple_hipA; pfam13657 1114970008742 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1114970008743 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1114970008744 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1114970008745 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 1114970008746 putative NADP binding site [chemical binding]; other site 1114970008747 putative substrate binding site [chemical binding]; other site 1114970008748 active site 1114970008749 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1114970008750 DNA binding residues [nucleotide binding] 1114970008751 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1114970008752 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1114970008753 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1114970008754 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114970008755 non-specific DNA binding site [nucleotide binding]; other site 1114970008756 salt bridge; other site 1114970008757 sequence-specific DNA binding site [nucleotide binding]; other site 1114970008758 Cupin domain; Region: Cupin_2; pfam07883 1114970008759 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1114970008760 B3/4 domain; Region: B3_4; pfam03483 1114970008761 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1114970008762 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1114970008763 inhibitor site; inhibition site 1114970008764 active site 1114970008765 dimer interface [polypeptide binding]; other site 1114970008766 catalytic residue [active] 1114970008767 DinB family; Region: DinB; cl17821 1114970008768 threonine synthase; Validated; Region: PRK09225 1114970008769 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1114970008770 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114970008771 catalytic residue [active] 1114970008772 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1114970008773 AsnC family; Region: AsnC_trans_reg; pfam01037 1114970008774 homoserine dehydrogenase; Provisional; Region: PRK06270 1114970008775 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1114970008776 NAD(P) binding pocket [chemical binding]; other site 1114970008777 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1114970008778 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970008779 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 1114970008780 NAD(P) binding site [chemical binding]; other site 1114970008781 catalytic residues [active] 1114970008782 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1114970008783 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1114970008784 homodimer interface [polypeptide binding]; other site 1114970008785 substrate-cofactor binding pocket; other site 1114970008786 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970008787 catalytic residue [active] 1114970008788 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1114970008789 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970008790 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970008791 substrate binding pocket [chemical binding]; other site 1114970008792 membrane-bound complex binding site; other site 1114970008793 hinge residues; other site 1114970008794 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114970008795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970008796 dimer interface [polypeptide binding]; other site 1114970008797 conserved gate region; other site 1114970008798 putative PBP binding loops; other site 1114970008799 ABC-ATPase subunit interface; other site 1114970008800 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114970008801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970008802 dimer interface [polypeptide binding]; other site 1114970008803 conserved gate region; other site 1114970008804 putative PBP binding loops; other site 1114970008805 ABC-ATPase subunit interface; other site 1114970008806 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1114970008807 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1114970008808 Walker A/P-loop; other site 1114970008809 ATP binding site [chemical binding]; other site 1114970008810 Q-loop/lid; other site 1114970008811 ABC transporter signature motif; other site 1114970008812 Walker B; other site 1114970008813 D-loop; other site 1114970008814 H-loop/switch region; other site 1114970008815 Cache domain; Region: Cache_1; pfam02743 1114970008816 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970008817 dimerization interface [polypeptide binding]; other site 1114970008818 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970008819 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970008820 dimer interface [polypeptide binding]; other site 1114970008821 putative CheW interface [polypeptide binding]; other site 1114970008822 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1114970008823 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970008824 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970008825 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 1114970008826 putative substrate binding pocket [chemical binding]; other site 1114970008827 putative dimerization interface [polypeptide binding]; other site 1114970008828 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 1114970008829 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1114970008830 putative NAD(P) binding site [chemical binding]; other site 1114970008831 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1114970008832 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970008833 DNA-binding site [nucleotide binding]; DNA binding site 1114970008834 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970008835 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970008836 homodimer interface [polypeptide binding]; other site 1114970008837 catalytic residue [active] 1114970008838 phosphoglucomutase; Validated; Region: PRK07564 1114970008839 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1114970008840 active site 1114970008841 substrate binding site [chemical binding]; other site 1114970008842 metal binding site [ion binding]; metal-binding site 1114970008843 Pirin-related protein [General function prediction only]; Region: COG1741 1114970008844 Pirin; Region: Pirin; pfam02678 1114970008845 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 1114970008846 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1114970008847 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1114970008848 Family description; Region: UvrD_C_2; pfam13538 1114970008849 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1114970008850 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1114970008851 AsnC family; Region: AsnC_trans_reg; pfam01037 1114970008852 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1114970008853 EamA-like transporter family; Region: EamA; pfam00892 1114970008854 EamA-like transporter family; Region: EamA; pfam00892 1114970008855 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 1114970008856 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970008857 tetrameric interface [polypeptide binding]; other site 1114970008858 activator binding site; other site 1114970008859 NADP binding site [chemical binding]; other site 1114970008860 substrate binding site [chemical binding]; other site 1114970008861 catalytic residues [active] 1114970008862 Autotransporter beta-domain; Region: Autotransporter; smart00869 1114970008863 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1114970008864 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1114970008865 Autotransporter beta-domain; Region: Autotransporter; smart00869 1114970008866 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 1114970008867 putative catalytic site [active] 1114970008868 putative metal binding site [ion binding]; other site 1114970008869 putative phosphate binding site [ion binding]; other site 1114970008870 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 1114970008871 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1114970008872 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1114970008873 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1114970008874 active site 1114970008875 catalytic site [active] 1114970008876 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 1114970008877 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 1114970008878 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1114970008879 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1114970008880 active site 1114970008881 catalytic site [active] 1114970008882 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1114970008883 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1114970008884 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1114970008885 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1114970008886 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1114970008887 catalytic site [active] 1114970008888 active site 1114970008889 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1114970008890 glycogen synthase; Provisional; Region: glgA; PRK00654 1114970008891 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1114970008892 ADP-binding pocket [chemical binding]; other site 1114970008893 homodimer interface [polypeptide binding]; other site 1114970008894 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 1114970008895 dimerization interface [polypeptide binding]; other site 1114970008896 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1114970008897 NAD binding site [chemical binding]; other site 1114970008898 ligand binding site [chemical binding]; other site 1114970008899 catalytic site [active] 1114970008900 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 1114970008901 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1114970008902 Predicted membrane protein [Function unknown]; Region: COG1238 1114970008903 Protein of unknown function, DUF; Region: DUF411; cl01142 1114970008904 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 1114970008905 Penicillin amidase; Region: Penicil_amidase; pfam01804 1114970008906 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1114970008907 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 1114970008908 active site 1114970008909 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1114970008910 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1114970008911 FecR protein; Region: FecR; pfam04773 1114970008912 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 1114970008913 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1114970008914 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970008915 DNA-binding site [nucleotide binding]; DNA binding site 1114970008916 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1114970008917 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1114970008918 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1114970008919 FMN-binding pocket [chemical binding]; other site 1114970008920 flavin binding motif; other site 1114970008921 phosphate binding motif [ion binding]; other site 1114970008922 beta-alpha-beta structure motif; other site 1114970008923 NAD binding pocket [chemical binding]; other site 1114970008924 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1114970008925 catalytic loop [active] 1114970008926 iron binding site [ion binding]; other site 1114970008927 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1114970008928 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1114970008929 iron-sulfur cluster [ion binding]; other site 1114970008930 [2Fe-2S] cluster binding site [ion binding]; other site 1114970008931 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 1114970008932 alpha subunit interface [polypeptide binding]; other site 1114970008933 active site 1114970008934 substrate binding site [chemical binding]; other site 1114970008935 Fe binding site [ion binding]; other site 1114970008936 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1114970008937 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970008938 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 1114970008939 putative dimerization interface [polypeptide binding]; other site 1114970008940 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1114970008941 SAM (Sterile alpha motif ); Region: SAM_superfamily; cl15755 1114970008942 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1114970008943 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1114970008944 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1114970008945 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1114970008946 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1114970008947 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1114970008948 homotrimer interaction site [polypeptide binding]; other site 1114970008949 putative active site [active] 1114970008950 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1114970008951 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970008952 substrate binding pocket [chemical binding]; other site 1114970008953 membrane-bound complex binding site; other site 1114970008954 hinge residues; other site 1114970008955 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 1114970008956 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1114970008957 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1114970008958 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970008959 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1114970008960 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 1114970008961 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970008962 NAD binding site [chemical binding]; other site 1114970008963 catalytic residues [active] 1114970008964 substrate binding site [chemical binding]; other site 1114970008965 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 1114970008966 L-rhamnonate dehydratase; Provisional; Region: PRK15440 1114970008967 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 1114970008968 putative active site pocket [active] 1114970008969 putative metal binding site [ion binding]; other site 1114970008970 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1114970008971 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970008972 putative substrate translocation pore; other site 1114970008973 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1114970008974 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970008975 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 1114970008976 putative dimerization interface [polypeptide binding]; other site 1114970008977 Leucine rich repeat; Region: LRR_8; pfam13855 1114970008978 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1114970008979 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1114970008980 S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672 1114970008981 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970008982 S-adenosylmethionine binding site [chemical binding]; other site 1114970008983 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 1114970008984 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 1114970008985 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1114970008986 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1114970008987 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1114970008988 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1114970008989 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970008990 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114970008991 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1114970008992 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970008993 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114970008994 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1114970008995 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1114970008996 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1114970008997 FOG: CBS domain [General function prediction only]; Region: COG0517 1114970008998 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1114970008999 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1114970009000 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114970009001 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114970009002 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970009003 metal binding site [ion binding]; metal-binding site 1114970009004 active site 1114970009005 I-site; other site 1114970009006 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 1114970009007 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1114970009008 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970009009 Phytase; Region: Phytase; cl17685 1114970009010 Phytase; Region: Phytase; cl17685 1114970009011 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1114970009012 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1114970009013 TolR protein; Region: tolR; TIGR02801 1114970009014 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1114970009015 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970009016 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970009017 active site 1114970009018 phosphorylation site [posttranslational modification] 1114970009019 intermolecular recognition site; other site 1114970009020 dimerization interface [polypeptide binding]; other site 1114970009021 CHASE3 domain; Region: CHASE3; pfam05227 1114970009022 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1114970009023 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970009024 putative active site [active] 1114970009025 heme pocket [chemical binding]; other site 1114970009026 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970009027 dimer interface [polypeptide binding]; other site 1114970009028 phosphorylation site [posttranslational modification] 1114970009029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970009030 ATP binding site [chemical binding]; other site 1114970009031 G-X-G motif; other site 1114970009032 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970009033 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970009034 active site 1114970009035 phosphorylation site [posttranslational modification] 1114970009036 intermolecular recognition site; other site 1114970009037 dimerization interface [polypeptide binding]; other site 1114970009038 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114970009039 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970009040 active site 1114970009041 phosphorylation site [posttranslational modification] 1114970009042 intermolecular recognition site; other site 1114970009043 dimerization interface [polypeptide binding]; other site 1114970009044 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1114970009045 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970009046 DNA binding residues [nucleotide binding] 1114970009047 dimerization interface [polypeptide binding]; other site 1114970009048 Sensor protein DegS, frameshift 1114970009049 SnoaL-like domain; Region: SnoaL_3; pfam13474 1114970009050 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1114970009051 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970009052 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114970009053 DNA binding residues [nucleotide binding] 1114970009054 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1114970009055 FecR protein; Region: FecR; pfam04773 1114970009056 Secretin and TonB N terminus short domain; Region: STN; smart00965 1114970009057 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1114970009058 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970009059 N-terminal plug; other site 1114970009060 ligand-binding site [chemical binding]; other site 1114970009061 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 1114970009062 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1114970009063 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970009064 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114970009065 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 1114970009066 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 1114970009067 domain interface [polypeptide binding]; other site 1114970009068 putative active site [active] 1114970009069 catalytic site [active] 1114970009070 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 1114970009071 domain interface [polypeptide binding]; other site 1114970009072 putative active site [active] 1114970009073 catalytic site [active] 1114970009074 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1114970009075 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1114970009076 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114970009077 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1114970009078 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 1114970009079 putative NAD(P) binding site [chemical binding]; other site 1114970009080 active site 1114970009081 putative substrate binding site [chemical binding]; other site 1114970009082 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1114970009083 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1114970009084 Ligand binding site; other site 1114970009085 DXD motif; other site 1114970009086 Putative Catalytic site; other site 1114970009087 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 1114970009088 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1114970009089 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1114970009090 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1114970009091 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1114970009092 acyl-activating enzyme (AAE) consensus motif; other site 1114970009093 AMP binding site [chemical binding]; other site 1114970009094 active site 1114970009095 CoA binding site [chemical binding]; other site 1114970009096 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1114970009097 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970009098 NAD(P) binding site [chemical binding]; other site 1114970009099 active site 1114970009100 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 1114970009101 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1114970009102 dimer interface [polypeptide binding]; other site 1114970009103 active site 1114970009104 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1114970009105 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1114970009106 active site 1114970009107 enoyl-CoA hydratase; Provisional; Region: PRK05862 1114970009108 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114970009109 substrate binding site [chemical binding]; other site 1114970009110 oxyanion hole (OAH) forming residues; other site 1114970009111 trimer interface [polypeptide binding]; other site 1114970009112 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1114970009113 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1114970009114 active site 1114970009115 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1114970009116 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114970009117 substrate binding site [chemical binding]; other site 1114970009118 oxyanion hole (OAH) forming residues; other site 1114970009119 trimer interface [polypeptide binding]; other site 1114970009120 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1114970009121 HPP family; Region: HPP; pfam04982 1114970009122 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1114970009123 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1114970009124 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1114970009125 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1114970009126 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1114970009127 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1114970009128 H+ Antiporter protein; Region: 2A0121; TIGR00900 1114970009129 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 1114970009130 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1114970009131 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970009132 S-adenosylmethionine binding site [chemical binding]; other site 1114970009133 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1114970009134 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 1114970009135 homotrimer interaction site [polypeptide binding]; other site 1114970009136 putative active site [active] 1114970009137 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1114970009138 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1114970009139 Amidase; Region: Amidase; cl11426 1114970009140 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970009141 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114970009142 TIGR02646 family protein; Region: TIGR02646 1114970009143 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1114970009144 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1114970009145 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1114970009146 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1114970009147 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1114970009148 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1114970009149 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1114970009150 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1114970009151 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1114970009152 Transposase; Region: HTH_Tnp_1; pfam01527 1114970009153 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114970009154 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970009155 DNA binding residues [nucleotide binding] 1114970009156 dimerization interface [polypeptide binding]; other site 1114970009157 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 1114970009158 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970009159 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970009160 putative substrate translocation pore; other site 1114970009161 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 1114970009162 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1114970009163 active site 1114970009164 Zn binding site [ion binding]; other site 1114970009165 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 1114970009166 TLC ATP/ADP transporter; Region: TLC; cl03940 1114970009167 TLC ATP/ADP transporter; Region: TLC; cl03940 1114970009168 short chain dehydrogenase; Provisional; Region: PRK06197 1114970009169 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1114970009170 putative NAD(P) binding site [chemical binding]; other site 1114970009171 active site 1114970009172 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1114970009173 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1114970009174 HAMP domain; Region: HAMP; pfam00672 1114970009175 dimerization interface [polypeptide binding]; other site 1114970009176 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970009177 dimer interface [polypeptide binding]; other site 1114970009178 phosphorylation site [posttranslational modification] 1114970009179 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970009180 ATP binding site [chemical binding]; other site 1114970009181 Mg2+ binding site [ion binding]; other site 1114970009182 G-X-G motif; other site 1114970009183 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1114970009184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970009185 active site 1114970009186 phosphorylation site [posttranslational modification] 1114970009187 intermolecular recognition site; other site 1114970009188 dimerization interface [polypeptide binding]; other site 1114970009189 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970009190 DNA binding site [nucleotide binding] 1114970009191 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1114970009192 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1114970009193 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1114970009194 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 1114970009195 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 1114970009196 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 1114970009197 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 1114970009198 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 1114970009199 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 1114970009200 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1114970009201 active site 1114970009202 conserved hypothetical protein; Region: TIGR02270 1114970009203 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970009204 active site 1114970009205 outer membrane porin, OprD family; Region: OprD; pfam03573 1114970009206 benzoate transport; Region: 2A0115; TIGR00895 1114970009207 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970009208 putative substrate translocation pore; other site 1114970009209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970009210 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 1114970009211 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 1114970009212 putative NAD(P) binding site [chemical binding]; other site 1114970009213 active site 1114970009214 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 1114970009215 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1114970009216 catalytic loop [active] 1114970009217 iron binding site [ion binding]; other site 1114970009218 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 1114970009219 FAD binding pocket [chemical binding]; other site 1114970009220 FAD binding motif [chemical binding]; other site 1114970009221 phosphate binding motif [ion binding]; other site 1114970009222 beta-alpha-beta structure motif; other site 1114970009223 NAD binding pocket [chemical binding]; other site 1114970009224 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1114970009225 inter-subunit interface; other site 1114970009226 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 1114970009227 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 1114970009228 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 1114970009229 putative alpha subunit interface [polypeptide binding]; other site 1114970009230 putative active site [active] 1114970009231 putative substrate binding site [chemical binding]; other site 1114970009232 Fe binding site [ion binding]; other site 1114970009233 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1114970009234 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1114970009235 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970009236 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970009237 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 1114970009238 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 1114970009239 dimer interface [polypeptide binding]; other site 1114970009240 active site 1114970009241 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 1114970009242 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 1114970009243 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 1114970009244 octamer interface [polypeptide binding]; other site 1114970009245 active site 1114970009246 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1114970009247 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970009248 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 1114970009249 dimerizarion interface [polypeptide binding]; other site 1114970009250 CrgA pocket; other site 1114970009251 substrate binding pocket [chemical binding]; other site 1114970009252 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970009253 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970009254 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 1114970009255 putative effector binding pocket; other site 1114970009256 putative dimerization interface [polypeptide binding]; other site 1114970009257 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970009258 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970009259 putative substrate translocation pore; other site 1114970009260 acetylornithine deacetylase; Provisional; Region: PRK07522 1114970009261 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1114970009262 metal binding site [ion binding]; metal-binding site 1114970009263 putative dimer interface [polypeptide binding]; other site 1114970009264 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1114970009265 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1114970009266 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1114970009267 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1114970009268 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970009269 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1114970009270 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970009271 homodimer interface [polypeptide binding]; other site 1114970009272 catalytic residue [active] 1114970009273 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1114970009274 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1114970009275 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114970009276 non-specific DNA binding site [nucleotide binding]; other site 1114970009277 salt bridge; other site 1114970009278 sequence-specific DNA binding site [nucleotide binding]; other site 1114970009279 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114970009280 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114970009281 DNA binding site [nucleotide binding] 1114970009282 domain linker motif; other site 1114970009283 Ligand-binding domain of putative DNA transcription repressors highly similar to that of the repressor specific for gluconate (GntR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_2; cd06282 1114970009284 putative dimerization interface [polypeptide binding]; other site 1114970009285 putative ligand binding site [chemical binding]; other site 1114970009286 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 1114970009287 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1114970009288 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1114970009289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970009290 dimer interface [polypeptide binding]; other site 1114970009291 conserved gate region; other site 1114970009292 putative PBP binding loops; other site 1114970009293 ABC-ATPase subunit interface; other site 1114970009294 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1114970009295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970009296 dimer interface [polypeptide binding]; other site 1114970009297 conserved gate region; other site 1114970009298 putative PBP binding loops; other site 1114970009299 ABC-ATPase subunit interface; other site 1114970009300 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1114970009301 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114970009302 Walker A/P-loop; other site 1114970009303 ATP binding site [chemical binding]; other site 1114970009304 Q-loop/lid; other site 1114970009305 ABC transporter signature motif; other site 1114970009306 Walker B; other site 1114970009307 D-loop; other site 1114970009308 H-loop/switch region; other site 1114970009309 TOBE domain; Region: TOBE_2; pfam08402 1114970009310 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1114970009311 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1114970009312 active site 1114970009313 metal binding site [ion binding]; metal-binding site 1114970009314 hexamer interface [polypeptide binding]; other site 1114970009315 outer membrane porin, OprD family; Region: OprD; pfam03573 1114970009316 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1114970009317 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1114970009318 catalytic loop [active] 1114970009319 iron binding site [ion binding]; other site 1114970009320 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1114970009321 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1114970009322 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1114970009323 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1114970009324 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1114970009325 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1114970009326 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1114970009327 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970009328 Flagellin N-methylase; Region: FliB; pfam03692 1114970009329 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1114970009330 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970009331 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970009332 dimer interface [polypeptide binding]; other site 1114970009333 putative CheW interface [polypeptide binding]; other site 1114970009334 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 1114970009335 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970009336 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970009337 homodimer interface [polypeptide binding]; other site 1114970009338 catalytic residue [active] 1114970009339 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1114970009340 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114970009341 short chain dehydrogenase; Provisional; Region: PRK06701 1114970009342 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1114970009343 NAD binding site [chemical binding]; other site 1114970009344 metal binding site [ion binding]; metal-binding site 1114970009345 active site 1114970009346 Predicted membrane protein [Function unknown]; Region: COG2323 1114970009347 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1114970009348 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 1114970009349 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 1114970009350 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 1114970009351 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1114970009352 active site 1114970009353 DNA binding site [nucleotide binding] 1114970009354 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1114970009355 DNA binding site [nucleotide binding] 1114970009356 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 1114970009357 nucleotide binding site [chemical binding]; other site 1114970009358 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1114970009359 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1114970009360 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970009361 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1114970009362 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1114970009363 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970009364 PAS domain; Region: PAS_9; pfam13426 1114970009365 putative active site [active] 1114970009366 heme pocket [chemical binding]; other site 1114970009367 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970009368 dimer interface [polypeptide binding]; other site 1114970009369 phosphorylation site [posttranslational modification] 1114970009370 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970009371 ATP binding site [chemical binding]; other site 1114970009372 Mg2+ binding site [ion binding]; other site 1114970009373 G-X-G motif; other site 1114970009374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970009375 active site 1114970009376 phosphorylation site [posttranslational modification] 1114970009377 intermolecular recognition site; other site 1114970009378 dimerization interface [polypeptide binding]; other site 1114970009379 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1114970009380 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1114970009381 ATP binding site [chemical binding]; other site 1114970009382 DEAD_2; Region: DEAD_2; pfam06733 1114970009383 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1114970009384 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 1114970009385 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1114970009386 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1114970009387 nucleophilic elbow; other site 1114970009388 catalytic triad; other site 1114970009389 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1114970009390 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1114970009391 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1114970009392 HlyD family secretion protein; Region: HlyD_3; pfam13437 1114970009393 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 1114970009394 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 1114970009395 Walker A/P-loop; other site 1114970009396 ATP binding site [chemical binding]; other site 1114970009397 Q-loop/lid; other site 1114970009398 ABC transporter signature motif; other site 1114970009399 Walker B; other site 1114970009400 D-loop; other site 1114970009401 H-loop/switch region; other site 1114970009402 Protease inhibitor Inh; Region: Inh; pfam02974 1114970009403 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 1114970009404 active site 1114970009405 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1114970009406 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970009407 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970009408 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 1114970009409 putative substrate binding pocket [chemical binding]; other site 1114970009410 putative dimerization interface [polypeptide binding]; other site 1114970009411 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970009412 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970009413 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970009414 Protein of unknown function (DUF1652); Region: DUF1652; pfam07865 1114970009415 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1114970009416 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1114970009417 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1114970009418 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1114970009419 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1114970009420 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970009421 NAD(P) binding site [chemical binding]; other site 1114970009422 3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428 1114970009423 active site 1114970009424 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970009425 NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152 1114970009426 NAD(P) binding site [chemical binding]; other site 1114970009427 catalytic residues [active] 1114970009428 Activator of aromatic catabolism; Region: XylR_N; pfam06505 1114970009429 V4R domain; Region: V4R; pfam02830 1114970009430 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1114970009431 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970009432 Walker A motif; other site 1114970009433 ATP binding site [chemical binding]; other site 1114970009434 Walker B motif; other site 1114970009435 arginine finger; other site 1114970009436 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1114970009437 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1114970009438 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970009439 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1114970009440 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1114970009441 sorbitol dehydrogenase; Provisional; Region: PRK07067 1114970009442 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970009443 NAD(P) binding site [chemical binding]; other site 1114970009444 active site 1114970009445 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1114970009446 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1114970009447 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970009448 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970009449 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1114970009450 putative dimerization interface [polypeptide binding]; other site 1114970009451 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1114970009452 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1114970009453 Citrate transporter; Region: CitMHS; pfam03600 1114970009454 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1114970009455 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1114970009456 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1114970009457 Predicted transcriptional regulator [Transcription]; Region: COG1959 1114970009458 Transcriptional regulator; Region: Rrf2; pfam02082 1114970009459 malate:quinone oxidoreductase; Validated; Region: PRK05257 1114970009460 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1114970009461 Predicted membrane protein [Function unknown]; Region: COG3503 1114970009462 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114970009463 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970009464 dimer interface [polypeptide binding]; other site 1114970009465 phosphorylation site [posttranslational modification] 1114970009466 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970009467 ATP binding site [chemical binding]; other site 1114970009468 G-X-G motif; other site 1114970009469 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1114970009470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970009471 active site 1114970009472 phosphorylation site [posttranslational modification] 1114970009473 intermolecular recognition site; other site 1114970009474 dimerization interface [polypeptide binding]; other site 1114970009475 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188 1114970009476 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1114970009477 putative active site [active] 1114970009478 metal binding site [ion binding]; metal-binding site 1114970009479 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1114970009480 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970009481 NAD(P) binding site [chemical binding]; other site 1114970009482 catalytic residues [active] 1114970009483 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 1114970009484 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 1114970009485 dimer interface [polypeptide binding]; other site 1114970009486 Trp docking motif [polypeptide binding]; other site 1114970009487 active site 1114970009488 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1114970009489 sulfur oxidation protein SoxY; Provisional; Region: PRK07474 1114970009490 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 1114970009491 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 1114970009492 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970009493 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970009494 substrate binding pocket [chemical binding]; other site 1114970009495 membrane-bound complex binding site; other site 1114970009496 hinge residues; other site 1114970009497 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1114970009498 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 1114970009499 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 1114970009500 dimer interface [polypeptide binding]; other site 1114970009501 Trp docking motif [polypeptide binding]; other site 1114970009502 active site 1114970009503 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1114970009504 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1114970009505 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1114970009506 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1114970009507 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1114970009508 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114970009509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970009510 active site 1114970009511 phosphorylation site [posttranslational modification] 1114970009512 intermolecular recognition site; other site 1114970009513 dimerization interface [polypeptide binding]; other site 1114970009514 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970009515 DNA binding residues [nucleotide binding] 1114970009516 dimerization interface [polypeptide binding]; other site 1114970009517 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1114970009518 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1114970009519 Histidine kinase; Region: HisKA_3; pfam07730 1114970009520 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970009521 ATP binding site [chemical binding]; other site 1114970009522 Mg2+ binding site [ion binding]; other site 1114970009523 G-X-G motif; other site 1114970009524 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1114970009525 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1114970009526 ligand binding site [chemical binding]; other site 1114970009527 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1114970009528 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1114970009529 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1114970009530 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1114970009531 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1114970009532 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1114970009533 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114970009534 Walker A/P-loop; other site 1114970009535 ATP binding site [chemical binding]; other site 1114970009536 Q-loop/lid; other site 1114970009537 ABC transporter signature motif; other site 1114970009538 Walker B; other site 1114970009539 D-loop; other site 1114970009540 H-loop/switch region; other site 1114970009541 alcohol ABC transporter, permease protein; Region: phenyl_ABC_PedC; TIGR03861 1114970009542 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1114970009543 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1114970009544 active site residue [active] 1114970009545 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114970009546 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970009547 active site 1114970009548 phosphorylation site [posttranslational modification] 1114970009549 intermolecular recognition site; other site 1114970009550 dimerization interface [polypeptide binding]; other site 1114970009551 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970009552 DNA binding residues [nucleotide binding] 1114970009553 dimerization interface [polypeptide binding]; other site 1114970009554 PAS fold; Region: PAS_7; pfam12860 1114970009555 PAS fold; Region: PAS_7; pfam12860 1114970009556 PAS domain S-box; Region: sensory_box; TIGR00229 1114970009557 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970009558 putative active site [active] 1114970009559 heme pocket [chemical binding]; other site 1114970009560 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114970009561 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970009562 dimer interface [polypeptide binding]; other site 1114970009563 phosphorylation site [posttranslational modification] 1114970009564 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970009565 ATP binding site [chemical binding]; other site 1114970009566 Mg2+ binding site [ion binding]; other site 1114970009567 G-X-G motif; other site 1114970009568 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1114970009569 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970009570 active site 1114970009571 phosphorylation site [posttranslational modification] 1114970009572 intermolecular recognition site; other site 1114970009573 dimerization interface [polypeptide binding]; other site 1114970009574 Uncharacterized conserved protein [Function unknown]; Region: COG3287 1114970009575 FIST N domain; Region: FIST; pfam08495 1114970009576 FIST C domain; Region: FIST_C; pfam10442 1114970009577 NosL; Region: NosL; pfam05573 1114970009578 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1114970009579 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1114970009580 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1114970009581 Walker A/P-loop; other site 1114970009582 ATP binding site [chemical binding]; other site 1114970009583 Q-loop/lid; other site 1114970009584 ABC transporter signature motif; other site 1114970009585 Walker B; other site 1114970009586 D-loop; other site 1114970009587 H-loop/switch region; other site 1114970009588 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1114970009589 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 1114970009590 nitrous-oxide reductase; Validated; Region: PRK02888 1114970009591 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1114970009592 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 1114970009593 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 1114970009594 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1114970009595 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1114970009596 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1114970009597 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1114970009598 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114970009599 Walker A/P-loop; other site 1114970009600 ATP binding site [chemical binding]; other site 1114970009601 Q-loop/lid; other site 1114970009602 ABC transporter signature motif; other site 1114970009603 Walker B; other site 1114970009604 D-loop; other site 1114970009605 H-loop/switch region; other site 1114970009606 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1114970009607 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114970009608 FeS/SAM binding site; other site 1114970009609 HemN C-terminal domain; Region: HemN_C; pfam06969 1114970009610 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 1114970009611 HemN C-terminal domain; Region: HemN_C; pfam06969 1114970009612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3399 1114970009613 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1114970009614 Right handed beta helix region; Region: Beta_helix; pfam13229 1114970009615 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1114970009616 Cadherin repeat-like domain; Region: CA_like; cl15786 1114970009617 Ca2+ binding site [ion binding]; other site 1114970009618 Cadherin repeat-like domain; Region: CA_like; cl15786 1114970009619 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1114970009620 Ca2+ binding site [ion binding]; other site 1114970009621 Protein of unknown function (DUF2717); Region: DUF2717; cl17568 1114970009622 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1114970009623 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1114970009624 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1114970009625 HlyD family secretion protein; Region: HlyD; pfam00529 1114970009626 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1114970009627 HlyD family secretion protein; Region: HlyD_3; pfam13437 1114970009628 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 1114970009629 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1114970009630 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 1114970009631 Walker A/P-loop; other site 1114970009632 ATP binding site [chemical binding]; other site 1114970009633 Q-loop/lid; other site 1114970009634 ABC transporter signature motif; other site 1114970009635 Walker B; other site 1114970009636 D-loop; other site 1114970009637 H-loop/switch region; other site 1114970009638 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970009639 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114970009640 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1114970009641 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1114970009642 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 1114970009643 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1114970009644 Beta-lactamase; Region: Beta-lactamase; pfam00144 1114970009645 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1114970009646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970009647 active site 1114970009648 phosphorylation site [posttranslational modification] 1114970009649 intermolecular recognition site; other site 1114970009650 dimerization interface [polypeptide binding]; other site 1114970009651 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970009652 DNA binding residues [nucleotide binding] 1114970009653 dimerization interface [polypeptide binding]; other site 1114970009654 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 1114970009655 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1114970009656 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114970009657 active site 1114970009658 ATP binding site [chemical binding]; other site 1114970009659 substrate binding site [chemical binding]; other site 1114970009660 activation loop (A-loop); other site 1114970009661 AAA ATPase domain; Region: AAA_16; pfam13191 1114970009662 Predicted ATPase [General function prediction only]; Region: COG3899 1114970009663 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1114970009664 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1114970009665 PAS domain S-box; Region: sensory_box; TIGR00229 1114970009666 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970009667 putative active site [active] 1114970009668 heme pocket [chemical binding]; other site 1114970009669 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970009670 ATP binding site [chemical binding]; other site 1114970009671 Mg2+ binding site [ion binding]; other site 1114970009672 G-X-G motif; other site 1114970009673 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970009674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970009675 active site 1114970009676 phosphorylation site [posttranslational modification] 1114970009677 intermolecular recognition site; other site 1114970009678 dimerization interface [polypeptide binding]; other site 1114970009679 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1114970009680 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970009681 putative substrate translocation pore; other site 1114970009682 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1114970009683 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1114970009684 HlyD family secretion protein; Region: HlyD_3; pfam13437 1114970009685 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1114970009686 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970009687 Walker A motif; other site 1114970009688 ATP binding site [chemical binding]; other site 1114970009689 Walker B motif; other site 1114970009690 arginine finger; other site 1114970009691 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1114970009692 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1114970009693 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1114970009694 Walker A/P-loop; other site 1114970009695 ATP binding site [chemical binding]; other site 1114970009696 Q-loop/lid; other site 1114970009697 ABC transporter signature motif; other site 1114970009698 Walker B; other site 1114970009699 D-loop; other site 1114970009700 H-loop/switch region; other site 1114970009701 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 1114970009702 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1114970009703 putative ligand binding site [chemical binding]; other site 1114970009704 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1114970009705 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1114970009706 TM-ABC transporter signature motif; other site 1114970009707 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1114970009708 TM-ABC transporter signature motif; other site 1114970009709 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1114970009710 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1114970009711 Walker A/P-loop; other site 1114970009712 ATP binding site [chemical binding]; other site 1114970009713 Q-loop/lid; other site 1114970009714 ABC transporter signature motif; other site 1114970009715 Walker B; other site 1114970009716 D-loop; other site 1114970009717 H-loop/switch region; other site 1114970009718 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1114970009719 acyl-activating enzyme (AAE) consensus motif; other site 1114970009720 active site 1114970009721 CoA binding site [chemical binding]; other site 1114970009722 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 1114970009723 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1114970009724 active site 1114970009725 dimer interface [polypeptide binding]; other site 1114970009726 non-prolyl cis peptide bond; other site 1114970009727 insertion regions; other site 1114970009728 FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566 1114970009729 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1114970009730 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1114970009731 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 1114970009732 Flavin binding site [chemical binding]; other site 1114970009733 Possible frameshift 1114970009734 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1114970009735 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1114970009736 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 1114970009737 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 1114970009738 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1114970009739 HSP70 interaction site [polypeptide binding]; other site 1114970009740 Fe-S protein assembly chaperone HscA; Region: HscA; TIGR01991 1114970009741 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 1114970009742 nucleotide binding site [chemical binding]; other site 1114970009743 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1114970009744 SBD interface [polypeptide binding]; other site 1114970009745 NAD-dependent deacetylase; Provisional; Region: PRK00481 1114970009746 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1114970009747 NAD+ binding site [chemical binding]; other site 1114970009748 substrate binding site [chemical binding]; other site 1114970009749 Zn binding site [ion binding]; other site 1114970009750 Protein of unknown function (DUF1810); Region: DUF1810; cl02370 1114970009751 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 1114970009752 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 1114970009753 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892 1114970009754 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 1114970009755 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1114970009756 [4Fe-4S] binding site [ion binding]; other site 1114970009757 molybdopterin cofactor binding site; other site 1114970009758 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1114970009759 molybdopterin cofactor binding site; other site 1114970009760 NapD protein; Region: NapD; pfam03927 1114970009761 Periplasmic nitrate reductase protein NapE; Region: NapE; pfam06796 1114970009762 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1114970009763 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1114970009764 hydrophobic ligand binding site; other site 1114970009765 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114970009766 active site 1114970009767 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 1114970009768 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 1114970009769 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114970009770 hypothetical protein; Provisional; Region: PRK06184 1114970009771 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114970009772 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1114970009773 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1114970009774 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1114970009775 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1114970009776 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1114970009777 acyl-activating enzyme (AAE) consensus motif; other site 1114970009778 active site 1114970009779 AMP binding site [chemical binding]; other site 1114970009780 CoA binding site [chemical binding]; other site 1114970009781 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1114970009782 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 1114970009783 putative NADP binding site [chemical binding]; other site 1114970009784 putative substrate binding site [chemical binding]; other site 1114970009785 active site 1114970009786 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970009787 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114970009788 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114970009789 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114970009790 putative DNA binding site [nucleotide binding]; other site 1114970009791 putative Zn2+ binding site [ion binding]; other site 1114970009792 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1114970009793 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970009794 Coenzyme A binding pocket [chemical binding]; other site 1114970009795 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 1114970009796 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1114970009797 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 1114970009798 Walker A/P-loop; other site 1114970009799 ATP binding site [chemical binding]; other site 1114970009800 Q-loop/lid; other site 1114970009801 ABC transporter signature motif; other site 1114970009802 Walker B; other site 1114970009803 D-loop; other site 1114970009804 H-loop/switch region; other site 1114970009805 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1114970009806 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1114970009807 Dehydroquinate synthase (DHQS)-like. DHQS catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS-like2; cd08198 1114970009808 active site 1114970009809 metal binding site [ion binding]; metal-binding site 1114970009810 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970009811 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114970009812 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970009813 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1114970009814 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1114970009815 tetramer interface [polypeptide binding]; other site 1114970009816 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970009817 catalytic residue [active] 1114970009818 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1114970009819 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1114970009820 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1114970009821 putative NAD(P) binding site [chemical binding]; other site 1114970009822 Helix-turn-helix domain; Region: HTH_18; pfam12833 1114970009823 glutathionine S-transferase; Provisional; Region: PRK10542 1114970009824 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1114970009825 C-terminal domain interface [polypeptide binding]; other site 1114970009826 GSH binding site (G-site) [chemical binding]; other site 1114970009827 dimer interface [polypeptide binding]; other site 1114970009828 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1114970009829 dimer interface [polypeptide binding]; other site 1114970009830 N-terminal domain interface [polypeptide binding]; other site 1114970009831 substrate binding pocket (H-site) [chemical binding]; other site 1114970009832 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1114970009833 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970009834 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1114970009835 dimerization interface [polypeptide binding]; other site 1114970009836 substrate binding pocket [chemical binding]; other site 1114970009837 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970009838 PAS domain; Region: PAS_9; pfam13426 1114970009839 putative active site [active] 1114970009840 heme pocket [chemical binding]; other site 1114970009841 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970009842 PAS domain; Region: PAS_9; pfam13426 1114970009843 putative active site [active] 1114970009844 heme pocket [chemical binding]; other site 1114970009845 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970009846 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970009847 dimer interface [polypeptide binding]; other site 1114970009848 putative CheW interface [polypeptide binding]; other site 1114970009849 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1114970009850 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970009851 dimer interface [polypeptide binding]; other site 1114970009852 phosphorylation site [posttranslational modification] 1114970009853 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970009854 ATP binding site [chemical binding]; other site 1114970009855 Mg2+ binding site [ion binding]; other site 1114970009856 G-X-G motif; other site 1114970009857 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1114970009858 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970009859 active site 1114970009860 phosphorylation site [posttranslational modification] 1114970009861 intermolecular recognition site; other site 1114970009862 dimerization interface [polypeptide binding]; other site 1114970009863 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114970009864 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1114970009865 active site 1114970009866 phosphorylation site [posttranslational modification] 1114970009867 intermolecular recognition site; other site 1114970009868 dimerization interface [polypeptide binding]; other site 1114970009869 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970009870 DNA binding residues [nucleotide binding] 1114970009871 dimerization interface [polypeptide binding]; other site 1114970009872 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1114970009873 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970009874 dimer interface [polypeptide binding]; other site 1114970009875 phosphorylation site [posttranslational modification] 1114970009876 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970009877 ATP binding site [chemical binding]; other site 1114970009878 Mg2+ binding site [ion binding]; other site 1114970009879 G-X-G motif; other site 1114970009880 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970009881 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970009882 active site 1114970009883 phosphorylation site [posttranslational modification] 1114970009884 intermolecular recognition site; other site 1114970009885 dimerization interface [polypeptide binding]; other site 1114970009886 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1114970009887 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1114970009888 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1114970009889 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1114970009890 FAD binding pocket [chemical binding]; other site 1114970009891 FAD binding motif [chemical binding]; other site 1114970009892 phosphate binding motif [ion binding]; other site 1114970009893 beta-alpha-beta structure motif; other site 1114970009894 NAD binding pocket [chemical binding]; other site 1114970009895 Heme binding pocket [chemical binding]; other site 1114970009896 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1114970009897 catalytic loop [active] 1114970009898 iron binding site [ion binding]; other site 1114970009899 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1114970009900 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 1114970009901 putative C-terminal domain interface [polypeptide binding]; other site 1114970009902 putative GSH binding site (G-site) [chemical binding]; other site 1114970009903 putative dimer interface [polypeptide binding]; other site 1114970009904 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 1114970009905 putative N-terminal domain interface [polypeptide binding]; other site 1114970009906 putative dimer interface [polypeptide binding]; other site 1114970009907 putative substrate binding pocket (H-site) [chemical binding]; other site 1114970009908 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970009909 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970009910 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 1114970009911 putative effector binding pocket; other site 1114970009912 putative dimerization interface [polypeptide binding]; other site 1114970009913 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970009914 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970009915 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970009916 dimerization interface [polypeptide binding]; other site 1114970009917 Cupin; Region: Cupin_6; pfam12852 1114970009918 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1114970009919 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970009920 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1114970009921 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1114970009922 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114970009923 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1114970009924 EamA-like transporter family; Region: EamA; pfam00892 1114970009925 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970009926 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970009927 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970009928 dimerization interface [polypeptide binding]; other site 1114970009929 amidase; Validated; Region: PRK06565 1114970009930 Amidase; Region: Amidase; cl11426 1114970009931 Thermostable hemolysin; Region: T_hemolysin; pfam12261 1114970009932 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_3; cd05914 1114970009933 AMP-binding enzyme; Region: AMP-binding; pfam00501 1114970009934 acyl-activating enzyme (AAE) consensus motif; other site 1114970009935 putative AMP binding site [chemical binding]; other site 1114970009936 putative active site [active] 1114970009937 putative CoA binding site [chemical binding]; other site 1114970009938 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1114970009939 heme binding pocket [chemical binding]; other site 1114970009940 heme ligand [chemical binding]; other site 1114970009941 short chain dehydrogenase; Provisional; Region: PRK09072 1114970009942 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970009943 NAD(P) binding site [chemical binding]; other site 1114970009944 active site 1114970009945 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114970009946 TPR motif; other site 1114970009947 binding surface 1114970009948 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1114970009949 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970009950 active site 1114970009951 phosphorylation site [posttranslational modification] 1114970009952 intermolecular recognition site; other site 1114970009953 dimerization interface [polypeptide binding]; other site 1114970009954 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970009955 DNA binding site [nucleotide binding] 1114970009956 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114970009957 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970009958 dimer interface [polypeptide binding]; other site 1114970009959 phosphorylation site [posttranslational modification] 1114970009960 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970009961 ATP binding site [chemical binding]; other site 1114970009962 Mg2+ binding site [ion binding]; other site 1114970009963 G-X-G motif; other site 1114970009964 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1114970009965 Predicted transporter component [General function prediction only]; Region: COG2391 1114970009966 Sulphur transport; Region: Sulf_transp; pfam04143 1114970009967 Predicted transporter component [General function prediction only]; Region: COG2391 1114970009968 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 1114970009969 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1114970009970 Putative phosphatase (DUF442); Region: DUF442; cl17385 1114970009971 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1114970009972 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1114970009973 PAS fold; Region: PAS_4; pfam08448 1114970009974 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970009975 putative active site [active] 1114970009976 heme pocket [chemical binding]; other site 1114970009977 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970009978 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1114970009979 Walker A motif; other site 1114970009980 ATP binding site [chemical binding]; other site 1114970009981 Walker B motif; other site 1114970009982 arginine finger; other site 1114970009983 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1114970009984 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1114970009985 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1114970009986 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1114970009987 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1114970009988 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 1114970009989 Cyd operon protein YbgE (Cyd_oper_YbgE); Region: Cyd_oper_YbgE; cl11451 1114970009990 Peptidase propeptide and YPEB domain; Region: PepSY_2; cl17877 1114970009991 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1114970009992 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1114970009993 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1114970009994 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1114970009995 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1114970009996 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1114970009997 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1114970009998 Ligand Binding Site [chemical binding]; other site 1114970009999 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1114970010000 Ligand Binding Site [chemical binding]; other site 1114970010001 Predicted membrane protein [Function unknown]; Region: COG3174 1114970010002 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 1114970010003 universal stress protein UspE; Provisional; Region: PRK11175 1114970010004 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1114970010005 Ligand Binding Site [chemical binding]; other site 1114970010006 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1114970010007 Ligand Binding Site [chemical binding]; other site 1114970010008 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970010009 Coenzyme A binding pocket [chemical binding]; other site 1114970010010 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1114970010011 Ligand Binding Site [chemical binding]; other site 1114970010012 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1114970010013 Ligand Binding Site [chemical binding]; other site 1114970010014 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1114970010015 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 1114970010016 putative NAD(P) binding site [chemical binding]; other site 1114970010017 putative substrate binding site [chemical binding]; other site 1114970010018 catalytic Zn binding site [ion binding]; other site 1114970010019 structural Zn binding site [ion binding]; other site 1114970010020 putative phosphoketolase; Provisional; Region: PRK05261 1114970010021 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1114970010022 TPP-binding site; other site 1114970010023 XFP C-terminal domain; Region: XFP_C; pfam09363 1114970010024 universal stress protein UspE; Provisional; Region: PRK11175 1114970010025 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1114970010026 Ligand Binding Site [chemical binding]; other site 1114970010027 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1114970010028 Ligand Binding Site [chemical binding]; other site 1114970010029 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1114970010030 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1114970010031 Beta-Casp domain; Region: Beta-Casp; smart01027 1114970010032 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1114970010033 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1114970010034 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1114970010035 ligand binding site [chemical binding]; other site 1114970010036 flexible hinge region; other site 1114970010037 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1114970010038 putative switch regulator; other site 1114970010039 non-specific DNA interactions [nucleotide binding]; other site 1114970010040 DNA binding site [nucleotide binding] 1114970010041 sequence specific DNA binding site [nucleotide binding]; other site 1114970010042 putative cAMP binding site [chemical binding]; other site 1114970010043 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 1114970010044 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1114970010045 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970010046 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1114970010047 dimerization interface [polypeptide binding]; other site 1114970010048 substrate binding pocket [chemical binding]; other site 1114970010049 outer membrane porin, OprD family; Region: OprD; pfam03573 1114970010050 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1114970010051 ApbE family; Region: ApbE; pfam02424 1114970010052 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1114970010053 Flavodoxin; Region: Flavodoxin_1; pfam00258 1114970010054 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like2; cd06201 1114970010055 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 1114970010056 FAD binding pocket [chemical binding]; other site 1114970010057 FAD binding motif [chemical binding]; other site 1114970010058 catalytic residues [active] 1114970010059 NAD binding pocket [chemical binding]; other site 1114970010060 phosphate binding motif [ion binding]; other site 1114970010061 beta-alpha-beta structure motif; other site 1114970010062 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 1114970010063 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 1114970010064 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114970010065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970010066 active site 1114970010067 phosphorylation site [posttranslational modification] 1114970010068 intermolecular recognition site; other site 1114970010069 dimerization interface [polypeptide binding]; other site 1114970010070 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970010071 DNA binding site [nucleotide binding] 1114970010072 sensor protein QseC; Provisional; Region: PRK10337 1114970010073 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970010074 dimer interface [polypeptide binding]; other site 1114970010075 phosphorylation site [posttranslational modification] 1114970010076 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970010077 ATP binding site [chemical binding]; other site 1114970010078 Mg2+ binding site [ion binding]; other site 1114970010079 G-X-G motif; other site 1114970010080 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1114970010081 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970010082 DNA-binding site [nucleotide binding]; DNA binding site 1114970010083 UTRA domain; Region: UTRA; pfam07702 1114970010084 benzoate transport; Region: 2A0115; TIGR00895 1114970010085 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970010086 putative substrate translocation pore; other site 1114970010087 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1114970010088 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1114970010089 active site 1114970010090 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1114970010091 active site 1114970010092 catalytic residues [active] 1114970010093 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970010094 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1114970010095 putative active site [active] 1114970010096 heme pocket [chemical binding]; other site 1114970010097 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970010098 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1114970010099 putative active site [active] 1114970010100 heme pocket [chemical binding]; other site 1114970010101 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970010102 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1114970010103 putative active site [active] 1114970010104 heme pocket [chemical binding]; other site 1114970010105 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970010106 putative active site [active] 1114970010107 heme pocket [chemical binding]; other site 1114970010108 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1114970010109 HWE histidine kinase; Region: HWE_HK; pfam07536 1114970010110 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1114970010111 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970010112 active site 1114970010113 phosphorylation site [posttranslational modification] 1114970010114 intermolecular recognition site; other site 1114970010115 dimerization interface [polypeptide binding]; other site 1114970010116 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1114970010117 HIT family signature motif; other site 1114970010118 catalytic residue [active] 1114970010119 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 1114970010120 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970010121 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970010122 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1114970010123 putative effector binding pocket; other site 1114970010124 putative dimerization interface [polypeptide binding]; other site 1114970010125 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1114970010126 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810 1114970010127 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114970010128 catalytic site [active] 1114970010129 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1114970010130 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1114970010131 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114970010132 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1114970010133 active site 1114970010134 catalytic tetrad [active] 1114970010135 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1114970010136 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114970010137 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1114970010138 active site 1114970010139 catalytic tetrad [active] 1114970010140 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1114970010141 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1114970010142 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114970010143 Walker A/P-loop; other site 1114970010144 ATP binding site [chemical binding]; other site 1114970010145 Q-loop/lid; other site 1114970010146 ABC transporter signature motif; other site 1114970010147 Walker B; other site 1114970010148 D-loop; other site 1114970010149 H-loop/switch region; other site 1114970010150 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970010151 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970010152 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1114970010153 dimerization interface [polypeptide binding]; other site 1114970010154 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 1114970010155 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1114970010156 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114970010157 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970010158 DNA binding residues [nucleotide binding] 1114970010159 dimerization interface [polypeptide binding]; other site 1114970010160 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1114970010161 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1114970010162 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1114970010163 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1114970010164 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970010165 Coenzyme A binding pocket [chemical binding]; other site 1114970010166 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970010167 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970010168 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1114970010169 putative effector binding pocket; other site 1114970010170 dimerization interface [polypeptide binding]; other site 1114970010171 Isochorismatase family; Region: Isochorismatase; pfam00857 1114970010172 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1114970010173 catalytic triad [active] 1114970010174 dimer interface [polypeptide binding]; other site 1114970010175 conserved cis-peptide bond; other site 1114970010176 Predicted transcriptional regulators [Transcription]; Region: COG1733 1114970010177 Predicted transcriptional regulator [Transcription]; Region: COG3432 1114970010178 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1114970010179 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1114970010180 Transposase; Region: HTH_Tnp_1; pfam01527 1114970010181 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1114970010182 Integrase core domain; Region: rve_3; cl15866 1114970010183 ferrichrome receptor precursor protein; Provisional; Region: PRK14050 1114970010184 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970010185 N-terminal plug; other site 1114970010186 ligand-binding site [chemical binding]; other site 1114970010187 fec operon regulator FecR; Reviewed; Region: PRK09774 1114970010188 FecR protein; Region: FecR; pfam04773 1114970010189 RNA polymerase sigma factor; Reviewed; Region: PRK12523 1114970010190 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114970010191 DNA binding residues [nucleotide binding] 1114970010192 RibD C-terminal domain; Region: RibD_C; cl17279 1114970010193 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1114970010194 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1114970010195 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1114970010196 protein binding site [polypeptide binding]; other site 1114970010197 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1114970010198 active site 1114970010199 catalytic residues [active] 1114970010200 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1114970010201 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1114970010202 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1114970010203 Uncharacterized conserved protein [Function unknown]; Region: COG4925 1114970010204 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970010205 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970010206 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1114970010207 putative effector binding pocket; other site 1114970010208 putative dimerization interface [polypeptide binding]; other site 1114970010209 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1114970010210 RHS Repeat; Region: RHS_repeat; pfam05593 1114970010211 RHS Repeat; Region: RHS_repeat; pfam05593 1114970010212 RHS Repeat; Region: RHS_repeat; pfam05593 1114970010213 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1114970010214 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1114970010215 formate dehydrogenase subunit gamma; Validated; Region: PRK05988 1114970010216 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 1114970010217 putative dimer interface [polypeptide binding]; other site 1114970010218 [2Fe-2S] cluster binding site [ion binding]; other site 1114970010219 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 1114970010220 putative dimer interface [polypeptide binding]; other site 1114970010221 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1114970010222 SLBB domain; Region: SLBB; pfam10531 1114970010223 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1114970010224 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1114970010225 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1114970010226 catalytic loop [active] 1114970010227 iron binding site [ion binding]; other site 1114970010228 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1114970010229 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1114970010230 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1114970010231 [4Fe-4S] binding site [ion binding]; other site 1114970010232 molybdopterin cofactor binding site; other site 1114970010233 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1114970010234 molybdopterin cofactor binding site; other site 1114970010235 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 1114970010236 Inclusion body protein; Region: PixA; pfam12306 1114970010237 isochorismate-pyruvate lyase; Reviewed; Region: PRK07075 1114970010238 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1114970010239 Isochorismatase family; Region: Isochorismatase; pfam00857 1114970010240 catalytic triad [active] 1114970010241 conserved cis-peptide bond; other site 1114970010242 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1114970010243 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970010244 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1114970010245 dimerization interface [polypeptide binding]; other site 1114970010246 substrate binding pocket [chemical binding]; other site 1114970010247 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1114970010248 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism]; Region: AraH; COG1172 1114970010249 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1114970010250 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1114970010251 TM-ABC transporter signature motif; other site 1114970010252 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 1114970010253 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1114970010254 Walker A/P-loop; other site 1114970010255 ATP binding site [chemical binding]; other site 1114970010256 Q-loop/lid; other site 1114970010257 ABC transporter signature motif; other site 1114970010258 Walker B; other site 1114970010259 D-loop; other site 1114970010260 H-loop/switch region; other site 1114970010261 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1114970010262 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1114970010263 D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634 1114970010264 putative ligand binding site [chemical binding]; other site 1114970010265 xylose isomerase; Provisional; Region: PRK05474 1114970010266 xylose isomerase; Region: xylose_isom_A; TIGR02630 1114970010267 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 1114970010268 putative dimerization interface [polypeptide binding]; other site 1114970010269 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114970010270 putative ligand binding site [chemical binding]; other site 1114970010271 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114970010272 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970010273 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970010274 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970010275 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1114970010276 putative effector binding pocket; other site 1114970010277 putative dimerization interface [polypeptide binding]; other site 1114970010278 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114970010279 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1114970010280 active site 1114970010281 catalytic tetrad [active] 1114970010282 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1114970010283 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1114970010284 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1114970010285 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1114970010286 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1114970010287 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1114970010288 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1114970010289 Family of unknown function (DUF633); Region: DUF633; pfam04816 1114970010290 CAAX protease self-immunity; Region: Abi; pfam02517 1114970010291 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970010292 hypothetical protein; Provisional; Region: PRK08317 1114970010293 Possible frameshift 1114970010294 Dyp-type peroxidase family; Region: Dyp_perox_fam; TIGR01413 1114970010295 short chain dehydrogenase; Provisional; Region: PRK06123 1114970010296 classical (c) SDRs; Region: SDR_c; cd05233 1114970010297 NAD(P) binding site [chemical binding]; other site 1114970010298 active site 1114970010299 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1114970010300 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970010301 DNA-binding site [nucleotide binding]; DNA binding site 1114970010302 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970010303 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970010304 homodimer interface [polypeptide binding]; other site 1114970010305 catalytic residue [active] 1114970010306 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 1114970010307 4Fe-4S binding domain; Region: Fer4_3; pfam12798 1114970010308 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1114970010309 Protein of unknown function (DUF3203); Region: DUF3203; pfam11462 1114970010310 MgtC family; Region: MgtC; pfam02308 1114970010311 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1114970010312 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1114970010313 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1114970010314 active site 1114970010315 homodimer interface [polypeptide binding]; other site 1114970010316 catalytic site [active] 1114970010317 acceptor binding site [chemical binding]; other site 1114970010318 trehalose synthase; Region: treS_nterm; TIGR02456 1114970010319 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1114970010320 active site 1114970010321 catalytic site [active] 1114970010322 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1114970010323 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1114970010324 glycogen branching enzyme; Provisional; Region: PRK05402 1114970010325 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1114970010326 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1114970010327 active site 1114970010328 catalytic site [active] 1114970010329 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1114970010330 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1114970010331 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1114970010332 active site 1114970010333 tetramer interface [polypeptide binding]; other site 1114970010334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970010335 D-galactonate transporter; Region: 2A0114; TIGR00893 1114970010336 putative substrate translocation pore; other site 1114970010337 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1114970010338 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970010339 DNA-binding site [nucleotide binding]; DNA binding site 1114970010340 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1114970010341 acetyl-CoA acetyltransferase; Provisional; Region: PRK05656 1114970010342 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1114970010343 dimer interface [polypeptide binding]; other site 1114970010344 active site 1114970010345 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1114970010346 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1114970010347 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970010348 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970010349 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1114970010350 putative dimerization interface [polypeptide binding]; other site 1114970010351 NAD-dependent deacetylase; Provisional; Region: PRK05333 1114970010352 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 1114970010353 NAD+ binding site [chemical binding]; other site 1114970010354 substrate binding site [chemical binding]; other site 1114970010355 Zn binding site [ion binding]; other site 1114970010356 General stress protein [General function prediction only]; Region: GsiB; COG3729 1114970010357 General stress protein [General function prediction only]; Region: GsiB; COG3729 1114970010358 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1114970010359 ZIP Zinc transporter; Region: Zip; pfam02535 1114970010360 glutaminase; Provisional; Region: PRK00971 1114970010361 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1114970010362 DNA topoisomerase III; Provisional; Region: PRK07726 1114970010363 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1114970010364 active site 1114970010365 putative interdomain interaction site [polypeptide binding]; other site 1114970010366 putative metal-binding site [ion binding]; other site 1114970010367 putative nucleotide binding site [chemical binding]; other site 1114970010368 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1114970010369 domain I; other site 1114970010370 DNA binding groove [nucleotide binding] 1114970010371 phosphate binding site [ion binding]; other site 1114970010372 domain II; other site 1114970010373 domain III; other site 1114970010374 nucleotide binding site [chemical binding]; other site 1114970010375 catalytic site [active] 1114970010376 domain IV; other site 1114970010377 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970010378 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970010379 active site 1114970010380 phosphorylation site [posttranslational modification] 1114970010381 intermolecular recognition site; other site 1114970010382 dimerization interface [polypeptide binding]; other site 1114970010383 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 1114970010384 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970010385 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114970010386 DNA binding residues [nucleotide binding] 1114970010387 fec operon regulator FecR; Reviewed; Region: PRK09774 1114970010388 FecR protein; Region: FecR; pfam04773 1114970010389 Secretin and TonB N terminus short domain; Region: STN; smart00965 1114970010390 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1114970010391 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970010392 N-terminal plug; other site 1114970010393 ligand-binding site [chemical binding]; other site 1114970010394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970010395 putative substrate translocation pore; other site 1114970010396 choline dehydrogenase; Validated; Region: PRK02106 1114970010397 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1114970010398 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1114970010399 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970010400 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970010401 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970010402 dimerization interface [polypeptide binding]; other site 1114970010403 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 1114970010404 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 1114970010405 FAD binding domain; Region: FAD_binding_4; pfam01565 1114970010406 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1114970010407 Protein involved in meta-pathway of phenol degradation [Energy production and conversion]; Region: COG4313 1114970010408 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1114970010409 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114970010410 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970010411 LexA repressor; Provisional; Region: PRK12423 1114970010412 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1114970010413 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1114970010414 Catalytic site [active] 1114970010415 Uncharacterized conserved protein [Function unknown]; Region: COG4544 1114970010416 DNA Polymerase Y-family; Region: PolY_like; cd03468 1114970010417 active site 1114970010418 DNA binding site [nucleotide binding] 1114970010419 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1114970010420 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 1114970010421 putative active site [active] 1114970010422 putative PHP Thumb interface [polypeptide binding]; other site 1114970010423 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1114970010424 generic binding surface I; other site 1114970010425 generic binding surface II; other site 1114970010426 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1114970010427 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970010428 putative active site [active] 1114970010429 heme pocket [chemical binding]; other site 1114970010430 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114970010431 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970010432 dimer interface [polypeptide binding]; other site 1114970010433 phosphorylation site [posttranslational modification] 1114970010434 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970010435 ATP binding site [chemical binding]; other site 1114970010436 G-X-G motif; other site 1114970010437 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970010438 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970010439 active site 1114970010440 phosphorylation site [posttranslational modification] 1114970010441 intermolecular recognition site; other site 1114970010442 dimerization interface [polypeptide binding]; other site 1114970010443 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 1114970010444 Protein of unknown function (DUF465); Region: DUF465; pfam04325 1114970010445 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970010446 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970010447 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1114970010448 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1114970010449 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1114970010450 catalytic core [active] 1114970010451 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 1114970010452 putative inner membrane peptidase; Provisional; Region: PRK11778 1114970010453 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1114970010454 tandem repeat interface [polypeptide binding]; other site 1114970010455 oligomer interface [polypeptide binding]; other site 1114970010456 active site residues [active] 1114970010457 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 1114970010458 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1114970010459 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1114970010460 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1114970010461 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_13; cd06324 1114970010462 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1114970010463 putative ligand binding site [chemical binding]; other site 1114970010464 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1114970010465 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1114970010466 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1114970010467 substrate binding pocket [chemical binding]; other site 1114970010468 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1114970010469 B12 binding site [chemical binding]; other site 1114970010470 cobalt ligand [ion binding]; other site 1114970010471 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1114970010472 Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934 1114970010473 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1114970010474 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 1114970010475 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1114970010476 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1114970010477 active site 1114970010478 SAM binding site [chemical binding]; other site 1114970010479 homodimer interface [polypeptide binding]; other site 1114970010480 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1114970010481 Predicted integral membrane protein [Function unknown]; Region: COG5446 1114970010482 Probable cobalt transporter subunit (CbtB); Region: CbtB; pfam09489 1114970010483 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 1114970010484 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1114970010485 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1114970010486 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1114970010487 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1114970010488 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1114970010489 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 1114970010490 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970010491 Walker A motif; other site 1114970010492 ATP binding site [chemical binding]; other site 1114970010493 Walker B motif; other site 1114970010494 arginine finger; other site 1114970010495 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1114970010496 metal ion-dependent adhesion site (MIDAS); other site 1114970010497 Putative catalytic domain, repeat 1, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_1; cd09172 1114970010498 PLD-like domain; Region: PLDc_2; pfam13091 1114970010499 putative active site [active] 1114970010500 catalytic site [active] 1114970010501 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 1114970010502 PLD-like domain; Region: PLDc_2; pfam13091 1114970010503 putative active site [active] 1114970010504 catalytic site [active] 1114970010505 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1114970010506 hypothetical protein; Provisional; Region: PRK10040 1114970010507 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970010508 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970010509 substrate binding pocket [chemical binding]; other site 1114970010510 membrane-bound complex binding site; other site 1114970010511 hinge residues; other site 1114970010512 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970010513 dimer interface [polypeptide binding]; other site 1114970010514 conserved gate region; other site 1114970010515 putative PBP binding loops; other site 1114970010516 ABC-ATPase subunit interface; other site 1114970010517 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114970010518 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970010519 dimer interface [polypeptide binding]; other site 1114970010520 conserved gate region; other site 1114970010521 putative PBP binding loops; other site 1114970010522 ABC-ATPase subunit interface; other site 1114970010523 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1114970010524 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1114970010525 Walker A/P-loop; other site 1114970010526 ATP binding site [chemical binding]; other site 1114970010527 Q-loop/lid; other site 1114970010528 ABC transporter signature motif; other site 1114970010529 Walker B; other site 1114970010530 D-loop; other site 1114970010531 H-loop/switch region; other site 1114970010532 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1114970010533 homotrimer interaction site [polypeptide binding]; other site 1114970010534 putative active site [active] 1114970010535 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1114970010536 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1114970010537 Bacterial transcriptional regulator; Region: IclR; pfam01614 1114970010538 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1114970010539 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 1114970010540 dimer interface [polypeptide binding]; other site 1114970010541 active site 1114970010542 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1114970010543 substrate binding site [chemical binding]; other site 1114970010544 catalytic residue [active] 1114970010545 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1114970010546 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1114970010547 substrate binding site [chemical binding]; other site 1114970010548 ATP binding site [chemical binding]; other site 1114970010549 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1114970010550 PAS fold; Region: PAS_4; pfam08448 1114970010551 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1114970010552 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970010553 heme pocket [chemical binding]; other site 1114970010554 putative active site [active] 1114970010555 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970010556 putative active site [active] 1114970010557 heme pocket [chemical binding]; other site 1114970010558 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970010559 dimer interface [polypeptide binding]; other site 1114970010560 phosphorylation site [posttranslational modification] 1114970010561 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970010562 ATP binding site [chemical binding]; other site 1114970010563 Mg2+ binding site [ion binding]; other site 1114970010564 G-X-G motif; other site 1114970010565 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1114970010566 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970010567 active site 1114970010568 phosphorylation site [posttranslational modification] 1114970010569 intermolecular recognition site; other site 1114970010570 dimerization interface [polypeptide binding]; other site 1114970010571 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 1114970010572 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1114970010573 Walker A motif; other site 1114970010574 ATP binding site [chemical binding]; other site 1114970010575 Walker B motif; other site 1114970010576 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 1114970010577 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 1114970010578 acyl-activating enzyme (AAE) consensus motif; other site 1114970010579 putative AMP binding site [chemical binding]; other site 1114970010580 putative active site [active] 1114970010581 putative CoA binding site [chemical binding]; other site 1114970010582 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1114970010583 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 1114970010584 NAD binding site [chemical binding]; other site 1114970010585 homotetramer interface [polypeptide binding]; other site 1114970010586 homodimer interface [polypeptide binding]; other site 1114970010587 substrate binding site [chemical binding]; other site 1114970010588 active site 1114970010589 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1114970010590 PAS domain; Region: PAS; smart00091 1114970010591 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 1114970010592 putative active site [active] 1114970010593 heme pocket [chemical binding]; other site 1114970010594 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970010595 Walker B motif; other site 1114970010596 arginine finger; other site 1114970010597 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1114970010598 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 1114970010599 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1114970010600 Walker A/P-loop; other site 1114970010601 ATP binding site [chemical binding]; other site 1114970010602 Q-loop/lid; other site 1114970010603 ABC transporter signature motif; other site 1114970010604 Walker B; other site 1114970010605 D-loop; other site 1114970010606 H-loop/switch region; other site 1114970010607 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114970010608 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1114970010609 Walker A/P-loop; other site 1114970010610 ATP binding site [chemical binding]; other site 1114970010611 Q-loop/lid; other site 1114970010612 ABC transporter signature motif; other site 1114970010613 Walker B; other site 1114970010614 D-loop; other site 1114970010615 H-loop/switch region; other site 1114970010616 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114970010617 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 1114970010618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970010619 dimer interface [polypeptide binding]; other site 1114970010620 conserved gate region; other site 1114970010621 putative PBP binding loops; other site 1114970010622 ABC-ATPase subunit interface; other site 1114970010623 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1114970010624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970010625 dimer interface [polypeptide binding]; other site 1114970010626 conserved gate region; other site 1114970010627 putative PBP binding loops; other site 1114970010628 ABC-ATPase subunit interface; other site 1114970010629 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1114970010630 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1114970010631 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1114970010632 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1114970010633 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1114970010634 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1114970010635 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1114970010636 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 1114970010637 active site 1114970010638 catalytic triad [active] 1114970010639 dimer interface [polypeptide binding]; other site 1114970010640 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970010641 Coenzyme A binding pocket [chemical binding]; other site 1114970010642 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114970010643 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970010644 active site 1114970010645 phosphorylation site [posttranslational modification] 1114970010646 intermolecular recognition site; other site 1114970010647 dimerization interface [polypeptide binding]; other site 1114970010648 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970010649 DNA binding residues [nucleotide binding] 1114970010650 dimerization interface [polypeptide binding]; other site 1114970010651 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1114970010652 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1114970010653 GIY-YIG motif/motif A; other site 1114970010654 active site 1114970010655 catalytic site [active] 1114970010656 putative DNA binding site [nucleotide binding]; other site 1114970010657 metal binding site [ion binding]; metal-binding site 1114970010658 UvrB/uvrC motif; Region: UVR; pfam02151 1114970010659 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1114970010660 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1114970010661 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1114970010662 integrase; Provisional; Region: PRK09692 1114970010663 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1114970010664 active site 1114970010665 Int/Topo IB signature motif; other site 1114970010666 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 1114970010667 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1114970010668 Catalytic site [active] 1114970010669 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1114970010670 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1114970010671 active site 1114970010672 DNA binding site [nucleotide binding] 1114970010673 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1114970010674 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 1114970010675 Putative helicase; Region: TraI_2; pfam07514 1114970010676 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 1114970010677 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 1114970010678 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 1114970010679 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 1114970010680 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 1114970010681 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 1114970010682 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1114970010683 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114970010684 non-specific DNA binding site [nucleotide binding]; other site 1114970010685 salt bridge; other site 1114970010686 sequence-specific DNA binding site [nucleotide binding]; other site 1114970010687 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1114970010688 HlyD family secretion protein; Region: HlyD_3; pfam13437 1114970010689 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1114970010690 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1114970010691 Walker A/P-loop; other site 1114970010692 ATP binding site [chemical binding]; other site 1114970010693 Q-loop/lid; other site 1114970010694 ABC transporter signature motif; other site 1114970010695 Walker B; other site 1114970010696 D-loop; other site 1114970010697 H-loop/switch region; other site 1114970010698 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1114970010699 Walker A/P-loop; other site 1114970010700 ATP binding site [chemical binding]; other site 1114970010701 Q-loop/lid; other site 1114970010702 ABC transporter signature motif; other site 1114970010703 Walker B; other site 1114970010704 D-loop; other site 1114970010705 H-loop/switch region; other site 1114970010706 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1114970010707 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1114970010708 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1114970010709 Acetokinase family; Region: Acetate_kinase; cl17229 1114970010710 Acetokinase family; Region: Acetate_kinase; cl17229 1114970010711 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114970010712 PGAP1-like protein; Region: PGAP1; pfam07819 1114970010713 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 1114970010714 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 1114970010715 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1114970010716 catalytic Zn binding site [ion binding]; other site 1114970010717 structural Zn binding site [ion binding]; other site 1114970010718 NAD(P) binding site [chemical binding]; other site 1114970010719 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1114970010720 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1114970010721 transmembrane helices; other site 1114970010722 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1114970010723 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1114970010724 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1114970010725 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1114970010726 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1114970010727 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1114970010728 IHF - DNA interface [nucleotide binding]; other site 1114970010729 IHF dimer interface [polypeptide binding]; other site 1114970010730 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 1114970010731 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 1114970010732 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1114970010733 Walker A motif; other site 1114970010734 ATP binding site [chemical binding]; other site 1114970010735 Walker B motif; other site 1114970010736 arginine finger; other site 1114970010737 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 1114970010738 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 1114970010739 integrating conjugative element protein, PFL_4704 family; Region: conj_TIGR03749 1114970010740 integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746 1114970010741 Protein of unknown function (DUF3487); Region: DUF3487; pfam11990 1114970010742 integrating conjugative element membrane protein, PFL_4702 family; Region: conj_TIGR03745 1114970010743 Protein of unknown function (DUF3262); Region: DUF3262; pfam11660 1114970010744 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 1114970010745 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 1114970010746 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 1114970010747 Domain of unknown function (DUF4400); Region: DUF4400; cl14023 1114970010748 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1114970010749 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1114970010750 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1114970010751 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1114970010752 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1114970010753 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1114970010754 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1114970010755 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1114970010756 Transposase; Region: HTH_Tnp_1; pfam01527 1114970010757 Domain of unknown function (DUF4400); Region: DUF4400; cl14023 1114970010758 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 1114970010759 conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754 1114970010760 integrating conjugative element protein, PFL_4695 family; Region: ICE_PFL_4695; TIGR03765 1114970010761 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 1114970010762 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 1114970010763 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 1114970010764 hypothetical protein; Reviewed; Region: PRK00024 1114970010765 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1114970010766 MPN+ (JAMM) motif; other site 1114970010767 Zinc-binding site [ion binding]; other site 1114970010768 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 1114970010769 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114970010770 sequence-specific DNA binding site [nucleotide binding]; other site 1114970010771 salt bridge; other site 1114970010772 DNA topoisomerase III; Provisional; Region: PRK07726 1114970010773 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1114970010774 active site 1114970010775 putative interdomain interaction site [polypeptide binding]; other site 1114970010776 putative metal-binding site [ion binding]; other site 1114970010777 putative nucleotide binding site [chemical binding]; other site 1114970010778 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1114970010779 domain I; other site 1114970010780 DNA binding groove [nucleotide binding] 1114970010781 phosphate binding site [ion binding]; other site 1114970010782 domain II; other site 1114970010783 domain III; other site 1114970010784 nucleotide binding site [chemical binding]; other site 1114970010785 catalytic site [active] 1114970010786 domain IV; other site 1114970010787 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1114970010788 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1114970010789 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1114970010790 dimer interface [polypeptide binding]; other site 1114970010791 ssDNA binding site [nucleotide binding]; other site 1114970010792 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1114970010793 Protein of unknown function (DUF3158); Region: DUF3158; pfam11358 1114970010794 integrating conjugative element protein, PFL_4669 family; Region: ICE_PFL4669; TIGR03761 1114970010795 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 1114970010796 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 1114970010797 ParB-like nuclease domain; Region: ParBc; pfam02195 1114970010798 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1114970010799 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 1114970010800 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970010801 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114970010802 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1114970010803 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1114970010804 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1114970010805 beta-ketothiolase; Provisional; Region: PRK09051 1114970010806 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1114970010807 dimer interface [polypeptide binding]; other site 1114970010808 active site 1114970010809 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1114970010810 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114970010811 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970010812 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970010813 dimerization interface [polypeptide binding]; other site 1114970010814 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970010815 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970010816 dimer interface [polypeptide binding]; other site 1114970010817 putative CheW interface [polypeptide binding]; other site 1114970010818 MarR family; Region: MarR; pfam01047 1114970010819 MarR family; Region: MarR_2; cl17246 1114970010820 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1114970010821 homodecamer interface [polypeptide binding]; other site 1114970010822 GTP cyclohydrolase I; Provisional; Region: PLN03044 1114970010823 active site 1114970010824 putative catalytic site residues [active] 1114970010825 zinc binding site [ion binding]; other site 1114970010826 GTP-CH-I/GFRP interaction surface; other site 1114970010827 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 1114970010828 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1114970010829 dimer interface [polypeptide binding]; other site 1114970010830 PYR/PP interface [polypeptide binding]; other site 1114970010831 TPP binding site [chemical binding]; other site 1114970010832 substrate binding site [chemical binding]; other site 1114970010833 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1114970010834 TPP-binding site [chemical binding]; other site 1114970010835 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1114970010836 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1114970010837 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1114970010838 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1114970010839 classical (c) SDRs; Region: SDR_c; cd05233 1114970010840 NAD(P) binding site [chemical binding]; other site 1114970010841 active site 1114970010842 SnoaL-like domain; Region: SnoaL_2; pfam12680 1114970010843 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1114970010844 Phosphotransferase enzyme family; Region: APH; pfam01636 1114970010845 active site 1114970010846 ATP binding site [chemical binding]; other site 1114970010847 substrate binding site [chemical binding]; other site 1114970010848 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970010849 NAD(P) binding site [chemical binding]; other site 1114970010850 active site 1114970010851 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970010852 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970010853 putative substrate translocation pore; other site 1114970010854 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1114970010855 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1114970010856 NAD(P) binding site [chemical binding]; other site 1114970010857 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114970010858 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970010859 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970010860 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 1114970010861 putative substrate binding pocket [chemical binding]; other site 1114970010862 dimerization interface [polypeptide binding]; other site 1114970010863 Amidohydrolase; Region: Amidohydro_2; pfam04909 1114970010864 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1114970010865 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970010866 NAD(P) binding site [chemical binding]; other site 1114970010867 active site 1114970010868 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1114970010869 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1114970010870 Ycf48-like protein; Provisional; Region: PRK13684 1114970010871 Ycf48-like protein; Provisional; Region: PRK13684 1114970010872 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1114970010873 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; cl17850 1114970010874 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1114970010875 active site 1114970010876 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1114970010877 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114970010878 substrate binding site [chemical binding]; other site 1114970010879 oxyanion hole (OAH) forming residues; other site 1114970010880 trimer interface [polypeptide binding]; other site 1114970010881 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1114970010882 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970010883 NAD(P) binding site [chemical binding]; other site 1114970010884 active site 1114970010885 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1114970010886 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1114970010887 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970010888 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114970010889 Cytochrome P450; Region: p450; cl12078 1114970010890 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1114970010891 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1114970010892 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970010893 NAD(P) binding site [chemical binding]; other site 1114970010894 active site 1114970010895 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1114970010896 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970010897 putative substrate translocation pore; other site 1114970010898 SnoaL-like domain; Region: SnoaL_2; pfam12680 1114970010899 short chain dehydrogenase; Provisional; Region: PRK06180 1114970010900 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1114970010901 NADP binding site [chemical binding]; other site 1114970010902 active site 1114970010903 steroid binding site; other site 1114970010904 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1114970010905 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1114970010906 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114970010907 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1114970010908 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1114970010909 catalytic loop [active] 1114970010910 iron binding site [ion binding]; other site 1114970010911 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970010912 putative substrate translocation pore; other site 1114970010913 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970010914 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1114970010915 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1114970010916 classical (c) SDRs; Region: SDR_c; cd05233 1114970010917 NAD(P) binding site [chemical binding]; other site 1114970010918 active site 1114970010919 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1114970010920 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 1114970010921 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 1114970010922 active site 1114970010923 Fe binding site [ion binding]; other site 1114970010924 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1114970010925 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1114970010926 Transmembrane secretion effector; Region: MFS_3; pfam05977 1114970010927 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1114970010928 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1114970010929 Bacterial transcriptional regulator; Region: IclR; pfam01614 1114970010930 lipid-transfer protein; Provisional; Region: PRK07855 1114970010931 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1114970010932 active site 1114970010933 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1114970010934 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1114970010935 DUF35 OB-fold domain; Region: DUF35; pfam01796 1114970010936 short chain dehydrogenase; Provisional; Region: PRK12828 1114970010937 dihydropteridine reductase (DHPR), classical (c) SDRs; Region: DHPR_SDR_c_like; cd05334 1114970010938 NAD binding site [chemical binding]; other site 1114970010939 homodimer interface [polypeptide binding]; other site 1114970010940 active site 1114970010941 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1114970010942 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1114970010943 This alignment model represents the N-terminal rieske domain of the oxygenase alpha subunit (DitA) of diterpenoid dioxygenase (DTDO). DTDO is a novel aromatic-ring-hydroxylating dioxygenase found in Pseudomonas and other proteobacteria that degrades...; Region: Rieske_RO_Alpha_DTDO; cd03536 1114970010944 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 1114970010945 beta subunit interface [polypeptide binding]; other site 1114970010946 alpha subunit interface [polypeptide binding]; other site 1114970010947 active site 1114970010948 substrate binding site [chemical binding]; other site 1114970010949 Fe binding site [ion binding]; other site 1114970010950 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1114970010951 inter-subunit interface; other site 1114970010952 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 1114970010953 short chain dehydrogenase; Provisional; Region: PRK12939 1114970010954 classical (c) SDRs; Region: SDR_c; cd05233 1114970010955 NAD(P) binding site [chemical binding]; other site 1114970010956 active site 1114970010957 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 1114970010958 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1114970010959 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 1114970010960 acyl-activating enzyme (AAE) consensus motif; other site 1114970010961 putative AMP binding site [chemical binding]; other site 1114970010962 putative active site [active] 1114970010963 putative CoA binding site [chemical binding]; other site 1114970010964 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970010965 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114970010966 Amidohydrolase; Region: Amidohydro_2; pfam04909 1114970010967 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1114970010968 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1114970010969 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK09260 1114970010970 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1114970010971 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1114970010972 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1114970010973 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1114970010974 dimer interface [polypeptide binding]; other site 1114970010975 active site 1114970010976 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1114970010977 Cytochrome P450; Region: p450; cl12078 1114970010978 Amidohydrolase; Region: Amidohydro_2; pfam04909 1114970010979 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1114970010980 active site 1114970010981 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1114970010982 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1114970010983 active site 1114970010984 enoyl-CoA hydratase; Provisional; Region: PRK09245 1114970010985 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114970010986 substrate binding site [chemical binding]; other site 1114970010987 oxyanion hole (OAH) forming residues; other site 1114970010988 trimer interface [polypeptide binding]; other site 1114970010989 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1114970010990 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1114970010991 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1114970010992 active site 1114970010993 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1114970010994 catalytic residues [active] 1114970010995 dimer interface [polypeptide binding]; other site 1114970010996 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1114970010997 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1114970010998 active site 1114970010999 ATP-binding site [chemical binding]; other site 1114970011000 pantoate-binding site; other site 1114970011001 HXXH motif; other site 1114970011002 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1114970011003 major facilitator superfamily transporter; Provisional; Region: PRK05122 1114970011004 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970011005 putative substrate translocation pore; other site 1114970011006 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970011007 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114970011008 integrating conjugative element protein, PFL_4695 family; Region: ICE_PFL_4695; TIGR03765 1114970011009 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1114970011010 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1114970011011 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1114970011012 HlyD family secretion protein; Region: HlyD_3; pfam13437 1114970011013 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1114970011014 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 1114970011015 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 1114970011016 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1114970011017 nitrous-oxide reductase; Validated; Region: PRK02888 1114970011018 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1114970011019 Right handed beta helix region; Region: Beta_helix; pfam13229 1114970011020 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1114970011021 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1114970011022 Walker A/P-loop; other site 1114970011023 ATP binding site [chemical binding]; other site 1114970011024 Q-loop/lid; other site 1114970011025 ABC transporter signature motif; other site 1114970011026 Walker B; other site 1114970011027 D-loop; other site 1114970011028 H-loop/switch region; other site 1114970011029 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1114970011030 NosL; Region: NosL; pfam05573 1114970011031 Cytochrome c; Region: Cytochrom_C; cl11414 1114970011032 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1114970011033 metal ion-dependent adhesion site (MIDAS); other site 1114970011034 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970011035 MoxR-like ATPases [General function prediction only]; Region: COG0714 1114970011036 Walker A motif; other site 1114970011037 ATP binding site [chemical binding]; other site 1114970011038 Walker B motif; other site 1114970011039 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1114970011040 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1114970011041 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1114970011042 Low-spin heme binding site [chemical binding]; other site 1114970011043 D-pathway; other site 1114970011044 Binuclear center (active site) [active] 1114970011045 K-pathway; other site 1114970011046 Putative proton exit pathway; other site 1114970011047 putative bifunctional cbb3-type cytochrome c oxidase subunit II/cytochrome c; Provisional; Region: PRK14486 1114970011048 Cytochrome c; Region: Cytochrom_C; pfam00034 1114970011049 Cytochrome c; Region: Cytochrom_C; pfam00034 1114970011050 FMN-binding domain; Region: FMN_bind; cl01081 1114970011051 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1114970011052 Cytochrome P450; Region: p450; cl12078 1114970011053 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 1114970011054 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1114970011055 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970011056 Walker A motif; other site 1114970011057 ATP binding site [chemical binding]; other site 1114970011058 Walker B motif; other site 1114970011059 arginine finger; other site 1114970011060 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 1114970011061 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1114970011062 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1114970011063 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1114970011064 iron binding site [ion binding]; other site 1114970011065 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 1114970011066 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114970011067 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970011068 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970011069 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1114970011070 putative effector binding pocket; other site 1114970011071 dimerization interface [polypeptide binding]; other site 1114970011072 3-hydroxyanthranilic acid dioxygenase; Region: 3-HAO; cl17399 1114970011073 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970011074 Pseudomonas fluorescens 4-hydroxymuconic semialdehyde dehydrogenase-like; Region: ALDH_HMSADH_HapE; cd07115 1114970011075 NAD(P) binding site [chemical binding]; other site 1114970011076 catalytic residues [active] 1114970011077 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1114970011078 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 1114970011079 active site 1114970011080 dimer interface [polypeptide binding]; other site 1114970011081 metal binding site [ion binding]; metal-binding site 1114970011082 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1114970011083 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 1114970011084 active site 1114970011085 YciI-like protein; Reviewed; Region: PRK12863 1114970011086 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1114970011087 iron-sulfur cluster [ion binding]; other site 1114970011088 [2Fe-2S] cluster binding site [ion binding]; other site 1114970011089 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1114970011090 Bacterial transcriptional regulator; Region: IclR; pfam01614 1114970011091 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970011092 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970011093 putative substrate translocation pore; other site 1114970011094 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970011095 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1114970011096 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1114970011097 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1114970011098 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1114970011099 Flavin Reductases; Region: FlaRed; cl00801 1114970011100 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1114970011101 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1114970011102 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1114970011103 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1114970011104 Bacterial transcriptional regulator; Region: IclR; pfam01614 1114970011105 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1114970011106 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1114970011107 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1114970011108 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 1114970011109 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1114970011110 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1114970011111 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1114970011112 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1114970011113 putative hydrophobic ligand binding site [chemical binding]; other site 1114970011114 protein interface [polypeptide binding]; other site 1114970011115 gate; other site 1114970011116 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 1114970011117 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1114970011118 Bacterial transcriptional regulator; Region: IclR; pfam01614 1114970011119 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1114970011120 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1114970011121 active site 1114970011122 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1114970011123 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1114970011124 active site 1114970011125 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1114970011126 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1114970011127 Dienelactone hydrolase family; Region: DLH; pfam01738 1114970011128 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1114970011129 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1114970011130 classical (c) SDRs; Region: SDR_c; cd05233 1114970011131 NAD(P) binding site [chemical binding]; other site 1114970011132 active site 1114970011133 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1114970011134 The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6, and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348 1114970011135 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114970011136 putative active site [active] 1114970011137 putative metal binding site [ion binding]; other site 1114970011138 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 1114970011139 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1114970011140 active site 1114970011141 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1114970011142 DUF35 OB-fold domain; Region: DUF35; pfam01796 1114970011143 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 1114970011144 Coenzyme A transferase; Region: CoA_trans; cl17247 1114970011145 Coenzyme A transferase; Region: CoA_trans; cl17247 1114970011146 putative transporter; Provisional; Region: PRK10504 1114970011147 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970011148 putative substrate translocation pore; other site 1114970011149 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1114970011150 outer membrane porin, OprD family; Region: OprD; pfam03573 1114970011151 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1114970011152 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1114970011153 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1114970011154 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 1114970011155 active site 1114970011156 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970011157 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970011158 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1114970011159 putative dimerization interface [polypeptide binding]; other site 1114970011160 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1114970011161 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 1114970011162 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 1114970011163 hypothetical protein; Provisional; Region: PRK09262 1114970011164 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1114970011165 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970011166 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970011167 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1114970011168 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970011169 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 1114970011170 putative dimerization interface [polypeptide binding]; other site 1114970011171 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1114970011172 Esterase/lipase [General function prediction only]; Region: COG1647 1114970011173 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1114970011174 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1114970011175 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1114970011176 PYR/PP interface [polypeptide binding]; other site 1114970011177 dimer interface [polypeptide binding]; other site 1114970011178 TPP binding site [chemical binding]; other site 1114970011179 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1114970011180 TPP-binding site [chemical binding]; other site 1114970011181 dimer interface [polypeptide binding]; other site 1114970011182 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1114970011183 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970011184 AAA domain; Region: AAA_33; pfam13671 1114970011185 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1114970011186 active site 1114970011187 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1114970011188 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1114970011189 AsnC family; Region: AsnC_trans_reg; pfam01037 1114970011190 LysE type translocator; Region: LysE; cl00565 1114970011191 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 1114970011192 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1114970011193 putative ligand binding site [chemical binding]; other site 1114970011194 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970011195 dimerization interface [polypeptide binding]; other site 1114970011196 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114970011197 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970011198 dimer interface [polypeptide binding]; other site 1114970011199 phosphorylation site [posttranslational modification] 1114970011200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970011201 ATP binding site [chemical binding]; other site 1114970011202 Mg2+ binding site [ion binding]; other site 1114970011203 G-X-G motif; other site 1114970011204 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970011205 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970011206 active site 1114970011207 phosphorylation site [posttranslational modification] 1114970011208 intermolecular recognition site; other site 1114970011209 dimerization interface [polypeptide binding]; other site 1114970011210 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114970011211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970011212 ATP binding site [chemical binding]; other site 1114970011213 Mg2+ binding site [ion binding]; other site 1114970011214 G-X-G motif; other site 1114970011215 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 1114970011216 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1114970011217 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1114970011218 HlyD family secretion protein; Region: HlyD_3; pfam13437 1114970011219 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1114970011220 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114970011221 putative DNA binding site [nucleotide binding]; other site 1114970011222 putative Zn2+ binding site [ion binding]; other site 1114970011223 AsnC family; Region: AsnC_trans_reg; pfam01037 1114970011224 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 1114970011225 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 1114970011226 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970011227 catalytic residue [active] 1114970011228 2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012 1114970011229 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1114970011230 dimer interface [polypeptide binding]; other site 1114970011231 TPP-binding site [chemical binding]; other site 1114970011232 Integrase core domain; Region: rve_3; cl15866 1114970011233 Transposase; Region: HTH_Tnp_1; pfam01527 1114970011234 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1114970011235 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 1114970011236 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 1114970011237 metal binding site [ion binding]; metal-binding site 1114970011238 dimer interface [polypeptide binding]; other site 1114970011239 hypothetical protein; Provisional; Region: PRK07079 1114970011240 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 1114970011241 metal binding site [ion binding]; metal-binding site 1114970011242 putative dimer interface [polypeptide binding]; other site 1114970011243 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1114970011244 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1114970011245 Walker A/P-loop; other site 1114970011246 ATP binding site [chemical binding]; other site 1114970011247 Q-loop/lid; other site 1114970011248 ABC transporter signature motif; other site 1114970011249 Walker B; other site 1114970011250 D-loop; other site 1114970011251 H-loop/switch region; other site 1114970011252 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114970011253 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1114970011254 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1114970011255 Walker A/P-loop; other site 1114970011256 ATP binding site [chemical binding]; other site 1114970011257 Q-loop/lid; other site 1114970011258 ABC transporter signature motif; other site 1114970011259 Walker B; other site 1114970011260 D-loop; other site 1114970011261 H-loop/switch region; other site 1114970011262 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114970011263 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1114970011264 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1114970011265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970011266 dimer interface [polypeptide binding]; other site 1114970011267 conserved gate region; other site 1114970011268 putative PBP binding loops; other site 1114970011269 ABC-ATPase subunit interface; other site 1114970011270 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1114970011271 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970011272 dimer interface [polypeptide binding]; other site 1114970011273 conserved gate region; other site 1114970011274 putative PBP binding loops; other site 1114970011275 ABC-ATPase subunit interface; other site 1114970011276 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1114970011277 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 1114970011278 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970011279 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970011280 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970011281 dimerization interface [polypeptide binding]; other site 1114970011282 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970011283 putative transporter; Provisional; Region: PRK10054 1114970011284 putative substrate translocation pore; other site 1114970011285 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1114970011286 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1114970011287 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 1114970011288 active site 1114970011289 catalytic site [active] 1114970011290 Zn binding site [ion binding]; other site 1114970011291 tetramer interface [polypeptide binding]; other site 1114970011292 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 1114970011293 active site 1114970011294 catalytic site [active] 1114970011295 Zn binding site [ion binding]; other site 1114970011296 tetramer interface [polypeptide binding]; other site 1114970011297 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970011298 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970011299 substrate binding pocket [chemical binding]; other site 1114970011300 membrane-bound complex binding site; other site 1114970011301 hinge residues; other site 1114970011302 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1114970011303 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1114970011304 Walker A/P-loop; other site 1114970011305 ATP binding site [chemical binding]; other site 1114970011306 Q-loop/lid; other site 1114970011307 ABC transporter signature motif; other site 1114970011308 Walker B; other site 1114970011309 D-loop; other site 1114970011310 H-loop/switch region; other site 1114970011311 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114970011312 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970011313 dimer interface [polypeptide binding]; other site 1114970011314 conserved gate region; other site 1114970011315 putative PBP binding loops; other site 1114970011316 ABC-ATPase subunit interface; other site 1114970011317 argininosuccinate lyase; Provisional; Region: PRK00855 1114970011318 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1114970011319 active sites [active] 1114970011320 tetramer interface [polypeptide binding]; other site 1114970011321 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970011322 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970011323 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1114970011324 dimerization interface [polypeptide binding]; other site 1114970011325 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1114970011326 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970011327 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1114970011328 dimerization interface [polypeptide binding]; other site 1114970011329 substrate binding pocket [chemical binding]; other site 1114970011330 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1114970011331 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1114970011332 EamA-like transporter family; Region: EamA; pfam00892 1114970011333 short chain dehydrogenase; Provisional; Region: PRK06123 1114970011334 classical (c) SDRs; Region: SDR_c; cd05233 1114970011335 NAD(P) binding site [chemical binding]; other site 1114970011336 active site 1114970011337 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1114970011338 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 1114970011339 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1114970011340 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1114970011341 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 1114970011342 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 1114970011343 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1114970011344 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14194 1114970011345 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1114970011346 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1114970011347 homodimer interface [polypeptide binding]; other site 1114970011348 NADP binding site [chemical binding]; other site 1114970011349 substrate binding site [chemical binding]; other site 1114970011350 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1114970011351 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1114970011352 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1114970011353 putative active site [active] 1114970011354 putative substrate binding site [chemical binding]; other site 1114970011355 putative cosubstrate binding site; other site 1114970011356 catalytic site [active] 1114970011357 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1114970011358 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114970011359 non-specific DNA binding site [nucleotide binding]; other site 1114970011360 salt bridge; other site 1114970011361 sequence-specific DNA binding site [nucleotide binding]; other site 1114970011362 Cupin domain; Region: Cupin_2; pfam07883 1114970011363 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 1114970011364 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1114970011365 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 1114970011366 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1114970011367 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 1114970011368 putative active site [active] 1114970011369 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 1114970011370 domain_subunit interface; other site 1114970011371 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1114970011372 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 1114970011373 active site 1114970011374 FMN binding site [chemical binding]; other site 1114970011375 substrate binding site [chemical binding]; other site 1114970011376 3Fe-4S cluster binding site [ion binding]; other site 1114970011377 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1114970011378 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14194 1114970011379 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1114970011380 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1114970011381 homodimer interface [polypeptide binding]; other site 1114970011382 NADP binding site [chemical binding]; other site 1114970011383 substrate binding site [chemical binding]; other site 1114970011384 Amino acid permease; Region: AA_permease_2; pfam13520 1114970011385 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 1114970011386 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 1114970011387 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1114970011388 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 1114970011389 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1114970011390 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1114970011391 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1114970011392 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1114970011393 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1114970011394 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1114970011395 putative active site [active] 1114970011396 putative substrate binding site [chemical binding]; other site 1114970011397 putative cosubstrate binding site; other site 1114970011398 catalytic site [active] 1114970011399 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 1114970011400 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1114970011401 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 1114970011402 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1114970011403 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1114970011404 FMN-binding pocket [chemical binding]; other site 1114970011405 flavin binding motif; other site 1114970011406 phosphate binding motif [ion binding]; other site 1114970011407 beta-alpha-beta structure motif; other site 1114970011408 NAD binding pocket [chemical binding]; other site 1114970011409 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1114970011410 catalytic loop [active] 1114970011411 iron binding site [ion binding]; other site 1114970011412 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1114970011413 Histidine kinase; Region: HisKA_3; pfam07730 1114970011414 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970011415 ATP binding site [chemical binding]; other site 1114970011416 Mg2+ binding site [ion binding]; other site 1114970011417 G-X-G motif; other site 1114970011418 transcriptional regulator NarL; Provisional; Region: PRK10651 1114970011419 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970011420 active site 1114970011421 phosphorylation site [posttranslational modification] 1114970011422 intermolecular recognition site; other site 1114970011423 dimerization interface [polypeptide binding]; other site 1114970011424 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970011425 DNA binding residues [nucleotide binding] 1114970011426 dimerization interface [polypeptide binding]; other site 1114970011427 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970011428 PAS domain; Region: PAS_9; pfam13426 1114970011429 putative active site [active] 1114970011430 heme pocket [chemical binding]; other site 1114970011431 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970011432 PAS fold; Region: PAS_3; pfam08447 1114970011433 putative active site [active] 1114970011434 heme pocket [chemical binding]; other site 1114970011435 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1114970011436 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1114970011437 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1114970011438 FOG: CBS domain [General function prediction only]; Region: COG0517 1114970011439 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1114970011440 FOG: CBS domain [General function prediction only]; Region: COG0517 1114970011441 Transporter associated domain; Region: CorC_HlyC; smart01091 1114970011442 Alcaligenes xylosoxidans NreA and related domains; this domain family was previously known as part of DUF156; Region: NreA-like_DUF156; cd10154 1114970011443 putative homodimer interface [polypeptide binding]; other site 1114970011444 putative homotetramer interface [polypeptide binding]; other site 1114970011445 putative metal binding site [ion binding]; other site 1114970011446 putative homodimer-homodimer interface [polypeptide binding]; other site 1114970011447 putative allosteric switch controlling residues; other site 1114970011448 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 1114970011449 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 1114970011450 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1114970011451 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1114970011452 Zn2+ binding site [ion binding]; other site 1114970011453 Mg2+ binding site [ion binding]; other site 1114970011454 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970011455 dimer interface [polypeptide binding]; other site 1114970011456 putative CheW interface [polypeptide binding]; other site 1114970011457 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970011458 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970011459 active site 1114970011460 phosphorylation site [posttranslational modification] 1114970011461 intermolecular recognition site; other site 1114970011462 dimerization interface [polypeptide binding]; other site 1114970011463 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1114970011464 anti sigma factor interaction site; other site 1114970011465 regulatory phosphorylation site [posttranslational modification]; other site 1114970011466 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1114970011467 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1114970011468 putative binding surface; other site 1114970011469 active site 1114970011470 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1114970011471 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970011472 ATP binding site [chemical binding]; other site 1114970011473 Mg2+ binding site [ion binding]; other site 1114970011474 G-X-G motif; other site 1114970011475 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1114970011476 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1114970011477 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1114970011478 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970011479 dimer interface [polypeptide binding]; other site 1114970011480 putative CheW interface [polypeptide binding]; other site 1114970011481 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1114970011482 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1114970011483 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1114970011484 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1114970011485 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970011486 S-adenosylmethionine binding site [chemical binding]; other site 1114970011487 CheD chemotactic sensory transduction; Region: CheD; cl00810 1114970011488 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1114970011489 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970011490 active site 1114970011491 phosphorylation site [posttranslational modification] 1114970011492 intermolecular recognition site; other site 1114970011493 dimerization interface [polypeptide binding]; other site 1114970011494 CheB methylesterase; Region: CheB_methylest; pfam01339 1114970011495 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114970011496 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970011497 active site 1114970011498 phosphorylation site [posttranslational modification] 1114970011499 intermolecular recognition site; other site 1114970011500 dimerization interface [polypeptide binding]; other site 1114970011501 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970011502 DNA binding residues [nucleotide binding] 1114970011503 dimerization interface [polypeptide binding]; other site 1114970011504 PAS domain S-box; Region: sensory_box; TIGR00229 1114970011505 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970011506 putative active site [active] 1114970011507 heme pocket [chemical binding]; other site 1114970011508 PAS fold; Region: PAS_4; pfam08448 1114970011509 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970011510 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1114970011511 putative active site [active] 1114970011512 heme pocket [chemical binding]; other site 1114970011513 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970011514 putative active site [active] 1114970011515 heme pocket [chemical binding]; other site 1114970011516 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1114970011517 Histidine kinase; Region: HisKA_3; pfam07730 1114970011518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1114970011519 Mg2+ binding site [ion binding]; other site 1114970011520 G-X-G motif; other site 1114970011521 Cache domain; Region: Cache_1; pfam02743 1114970011522 PAS domain S-box; Region: sensory_box; TIGR00229 1114970011523 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114970011524 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970011525 dimer interface [polypeptide binding]; other site 1114970011526 phosphorylation site [posttranslational modification] 1114970011527 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970011528 ATP binding site [chemical binding]; other site 1114970011529 Mg2+ binding site [ion binding]; other site 1114970011530 G-X-G motif; other site 1114970011531 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1114970011532 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970011533 active site 1114970011534 phosphorylation site [posttranslational modification] 1114970011535 intermolecular recognition site; other site 1114970011536 dimerization interface [polypeptide binding]; other site 1114970011537 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1114970011538 Zn2+ binding site [ion binding]; other site 1114970011539 Mg2+ binding site [ion binding]; other site 1114970011540 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970011541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970011542 putative substrate translocation pore; other site 1114970011543 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1114970011544 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1114970011545 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1114970011546 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114970011547 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1114970011548 dimer interface [polypeptide binding]; other site 1114970011549 OPT oligopeptide transporter protein; Region: OPT; cl14607 1114970011550 OPT oligopeptide transporter protein; Region: OPT; cl14607 1114970011551 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970011552 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970011553 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1114970011554 putative effector binding pocket; other site 1114970011555 dimerization interface [polypeptide binding]; other site 1114970011556 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1114970011557 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1114970011558 NADP binding site [chemical binding]; other site 1114970011559 dimer interface [polypeptide binding]; other site 1114970011560 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1114970011561 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1114970011562 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 1114970011563 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1114970011564 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1114970011565 GAF domain; Region: GAF; pfam01590 1114970011566 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114970011567 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970011568 metal binding site [ion binding]; metal-binding site 1114970011569 active site 1114970011570 I-site; other site 1114970011571 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970011572 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1114970011573 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1114970011574 substrate binding site [chemical binding]; other site 1114970011575 ligand binding site [chemical binding]; other site 1114970011576 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1114970011577 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1114970011578 substrate binding site [chemical binding]; other site 1114970011579 transcriptional activator TtdR; Provisional; Region: PRK09801 1114970011580 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970011581 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 1114970011582 putative effector binding pocket; other site 1114970011583 putative dimerization interface [polypeptide binding]; other site 1114970011584 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1114970011585 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1114970011586 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 1114970011587 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1114970011588 Citrate synthase; Region: Citrate_synt; pfam00285 1114970011589 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1114970011590 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1114970011591 oxalacetate binding site [chemical binding]; other site 1114970011592 citrylCoA binding site [chemical binding]; other site 1114970011593 coenzyme A binding site [chemical binding]; other site 1114970011594 catalytic triad [active] 1114970011595 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1114970011596 Citrate transporter; Region: CitMHS; pfam03600 1114970011597 outer membrane porin, OprD family; Region: OprD; pfam03573 1114970011598 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1114970011599 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1114970011600 NAD binding site [chemical binding]; other site 1114970011601 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1114970011602 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 1114970011603 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1114970011604 Secretory lipase; Region: LIP; pfam03583 1114970011605 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1114970011606 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970011607 DNA binding residues [nucleotide binding] 1114970011608 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1114970011609 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1114970011610 glutamine binding [chemical binding]; other site 1114970011611 catalytic triad [active] 1114970011612 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1114970011613 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1114970011614 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1114970011615 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1114970011616 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1114970011617 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1114970011618 active site 1114970011619 CoA binding site [chemical binding]; other site 1114970011620 AMP binding site [chemical binding]; other site 1114970011621 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1114970011622 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1114970011623 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1114970011624 EamA-like transporter family; Region: EamA; pfam00892 1114970011625 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114970011626 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1114970011627 catalytic site [active] 1114970011628 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1114970011629 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 3; Region: PLPDE_III_DSD_D-TA_like_3; cd06814 1114970011630 dimer interface [polypeptide binding]; other site 1114970011631 active site 1114970011632 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1114970011633 substrate binding site [chemical binding]; other site 1114970011634 catalytic residue [active] 1114970011635 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970011636 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1114970011637 putative substrate translocation pore; other site 1114970011638 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970011639 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970011640 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 1114970011641 putative dimerization interface [polypeptide binding]; other site 1114970011642 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1114970011643 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 1114970011644 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970011645 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970011646 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970011647 dimerization interface [polypeptide binding]; other site 1114970011648 hypothetical protein; Provisional; Region: PRK06102 1114970011649 Amidase; Region: Amidase; cl11426 1114970011650 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1114970011651 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1114970011652 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1114970011653 Na binding site [ion binding]; other site 1114970011654 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1114970011655 dimer interface [polypeptide binding]; other site 1114970011656 Creatinine amidohydrolase; Region: Creatininase; pfam02633 1114970011657 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1114970011658 Protein of unknown function (DUF1375); Region: DUF1375; pfam07119 1114970011659 Predicted transcriptional regulators [Transcription]; Region: COG1733 1114970011660 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1114970011661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970011662 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970011663 putative substrate translocation pore; other site 1114970011664 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1114970011665 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970011666 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970011667 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1114970011668 putative dimerization interface [polypeptide binding]; other site 1114970011669 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 1114970011670 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 1114970011671 Citrate transporter; Region: CitMHS; pfam03600 1114970011672 outer membrane porin, OprD family; Region: OprD; pfam03573 1114970011673 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970011674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970011675 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 1114970011676 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1114970011677 NAD binding site [chemical binding]; other site 1114970011678 homotetramer interface [polypeptide binding]; other site 1114970011679 homodimer interface [polypeptide binding]; other site 1114970011680 substrate binding site [chemical binding]; other site 1114970011681 active site 1114970011682 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 1114970011683 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1114970011684 Walker A/P-loop; other site 1114970011685 ATP binding site [chemical binding]; other site 1114970011686 Q-loop/lid; other site 1114970011687 ABC transporter signature motif; other site 1114970011688 Walker B; other site 1114970011689 D-loop; other site 1114970011690 H-loop/switch region; other site 1114970011691 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114970011692 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1114970011693 Walker A/P-loop; other site 1114970011694 ATP binding site [chemical binding]; other site 1114970011695 Q-loop/lid; other site 1114970011696 ABC transporter signature motif; other site 1114970011697 Walker B; other site 1114970011698 D-loop; other site 1114970011699 H-loop/switch region; other site 1114970011700 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114970011701 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 1114970011702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970011703 dimer interface [polypeptide binding]; other site 1114970011704 conserved gate region; other site 1114970011705 putative PBP binding loops; other site 1114970011706 ABC-ATPase subunit interface; other site 1114970011707 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1114970011708 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970011709 dimer interface [polypeptide binding]; other site 1114970011710 conserved gate region; other site 1114970011711 putative PBP binding loops; other site 1114970011712 ABC-ATPase subunit interface; other site 1114970011713 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1114970011714 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1114970011715 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1114970011716 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1114970011717 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1114970011718 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1114970011719 catalytic residue [active] 1114970011720 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114970011721 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 1114970011722 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114970011723 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 1114970011724 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1114970011725 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1114970011726 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1114970011727 RNA/DNA hybrid binding site [nucleotide binding]; other site 1114970011728 active site 1114970011729 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1114970011730 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1114970011731 active site 1114970011732 catalytic site [active] 1114970011733 substrate binding site [chemical binding]; other site 1114970011734 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970011735 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1114970011736 Coenzyme A binding pocket [chemical binding]; other site 1114970011737 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1114970011738 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970011739 dimerization interface [polypeptide binding]; other site 1114970011740 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1114970011741 Predicted flavoprotein [General function prediction only]; Region: COG0431 1114970011742 arsenical pump membrane protein; Provisional; Region: PRK15445 1114970011743 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1114970011744 transmembrane helices; other site 1114970011745 Domain of unknown function (DUF1853); Region: DUF1853; pfam08907 1114970011746 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231 1114970011747 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1114970011748 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1114970011749 active site 1114970011750 metal binding site [ion binding]; metal-binding site 1114970011751 Rhomboid family; Region: Rhomboid; pfam01694 1114970011752 Protein of unknown function (DUF1315); Region: DUF1315; cl01215 1114970011753 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 1114970011754 aminopeptidase N; Provisional; Region: pepN; PRK14015 1114970011755 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1114970011756 active site 1114970011757 Zn binding site [ion binding]; other site 1114970011758 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1114970011759 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1114970011760 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1114970011761 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970011762 DNA-binding site [nucleotide binding]; DNA binding site 1114970011763 FCD domain; Region: FCD; pfam07729 1114970011764 dihydroxy-acid dehydratase; Validated; Region: PRK06131 1114970011765 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970011766 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1114970011767 putative substrate translocation pore; other site 1114970011768 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 1114970011769 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1114970011770 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1114970011771 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1114970011772 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1114970011773 dimer interface [polypeptide binding]; other site 1114970011774 NADP binding site [chemical binding]; other site 1114970011775 catalytic residues [active] 1114970011776 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1114970011777 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1114970011778 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1114970011779 C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196 1114970011780 putative N-terminal domain interface [polypeptide binding]; other site 1114970011781 putative dimer interface [polypeptide binding]; other site 1114970011782 putative substrate binding pocket (H-site) [chemical binding]; other site 1114970011783 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114970011784 AAA domain; Region: AAA_23; pfam13476 1114970011785 Walker A/P-loop; other site 1114970011786 ATP binding site [chemical binding]; other site 1114970011787 Q-loop/lid; other site 1114970011788 exonuclease subunit SbcC; Provisional; Region: PRK10246 1114970011789 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114970011790 ABC transporter signature motif; other site 1114970011791 Walker B; other site 1114970011792 D-loop; other site 1114970011793 H-loop/switch region; other site 1114970011794 exonuclease subunit SbcD; Provisional; Region: PRK10966 1114970011795 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1114970011796 active site 1114970011797 metal binding site [ion binding]; metal-binding site 1114970011798 DNA binding site [nucleotide binding] 1114970011799 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1114970011800 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970011801 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1114970011802 putative substrate translocation pore; other site 1114970011803 Condensation domain; Region: Condensation; pfam00668 1114970011804 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1114970011805 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1114970011806 acyl-activating enzyme (AAE) consensus motif; other site 1114970011807 AMP binding site [chemical binding]; other site 1114970011808 active site 1114970011809 CoA binding site [chemical binding]; other site 1114970011810 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114970011811 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114970011812 active site 1114970011813 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114970011814 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1114970011815 putative NADP binding site [chemical binding]; other site 1114970011816 active site 1114970011817 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1114970011818 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970011819 S-adenosylmethionine binding site [chemical binding]; other site 1114970011820 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1114970011821 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1114970011822 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114970011823 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114970011824 active site 1114970011825 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1114970011826 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1114970011827 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 1114970011828 Isochorismatase family; Region: Isochorismatase; pfam00857 1114970011829 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1114970011830 catalytic triad [active] 1114970011831 dimer interface [polypeptide binding]; other site 1114970011832 conserved cis-peptide bond; other site 1114970011833 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114970011834 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1114970011835 putative NADP binding site [chemical binding]; other site 1114970011836 active site 1114970011837 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114970011838 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114970011839 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114970011840 active site 1114970011841 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114970011842 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1114970011843 putative NADP binding site [chemical binding]; other site 1114970011844 active site 1114970011845 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114970011846 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114970011847 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114970011848 active site 1114970011849 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114970011850 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114970011851 active site 1114970011852 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1114970011853 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114970011854 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1114970011855 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1114970011856 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1114970011857 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114970011858 Walker A/P-loop; other site 1114970011859 ATP binding site [chemical binding]; other site 1114970011860 ABC transporter signature motif; other site 1114970011861 Walker B; other site 1114970011862 D-loop; other site 1114970011863 H-loop/switch region; other site 1114970011864 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1114970011865 Oxygen tolerance; Region: BatD; pfam13584 1114970011866 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1114970011867 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1114970011868 metal ion-dependent adhesion site (MIDAS); other site 1114970011869 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114970011870 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1114970011871 TPR motif; other site 1114970011872 binding surface 1114970011873 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1114970011874 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 1114970011875 metal ion-dependent adhesion site (MIDAS); other site 1114970011876 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 1114970011877 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1114970011878 Protein of unknown function DUF58; Region: DUF58; pfam01882 1114970011879 MoxR-like ATPases [General function prediction only]; Region: COG0714 1114970011880 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970011881 Walker A motif; other site 1114970011882 ATP binding site [chemical binding]; other site 1114970011883 Walker B motif; other site 1114970011884 arginine finger; other site 1114970011885 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1114970011886 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 1114970011887 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114970011888 Walker A/P-loop; other site 1114970011889 ATP binding site [chemical binding]; other site 1114970011890 Q-loop/lid; other site 1114970011891 ABC transporter signature motif; other site 1114970011892 Walker B; other site 1114970011893 D-loop; other site 1114970011894 H-loop/switch region; other site 1114970011895 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1114970011896 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1114970011897 dimerization interface [polypeptide binding]; other site 1114970011898 ligand binding site [chemical binding]; other site 1114970011899 NADP binding site [chemical binding]; other site 1114970011900 catalytic site [active] 1114970011901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970011902 D-galactonate transporter; Region: 2A0114; TIGR00893 1114970011903 putative substrate translocation pore; other site 1114970011904 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1114970011905 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1114970011906 substrate binding site [chemical binding]; other site 1114970011907 ATP binding site [chemical binding]; other site 1114970011908 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1114970011909 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114970011910 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114970011911 DNA binding site [nucleotide binding] 1114970011912 domain linker motif; other site 1114970011913 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1114970011914 putative dimerization interface [polypeptide binding]; other site 1114970011915 putative ligand binding site [chemical binding]; other site 1114970011916 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1114970011917 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1114970011918 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1114970011919 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1114970011920 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970011921 DNA-binding site [nucleotide binding]; DNA binding site 1114970011922 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970011923 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970011924 homodimer interface [polypeptide binding]; other site 1114970011925 catalytic residue [active] 1114970011926 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1114970011927 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1114970011928 Secretin and TonB N terminus short domain; Region: STN; smart00965 1114970011929 TonB C terminal; Region: TonB_2; pfam13103 1114970011930 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1114970011931 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1114970011932 FecR protein; Region: FecR; pfam04773 1114970011933 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 1114970011934 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1114970011935 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 1114970011936 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 1114970011937 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1114970011938 Type II transport protein GspH; Region: GspH; pfam12019 1114970011939 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 1114970011940 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 1114970011941 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1114970011942 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1114970011943 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1114970011944 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 1114970011945 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 1114970011946 GspL periplasmic domain; Region: GspL_C; cl14909 1114970011947 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 1114970011948 type II secretion system protein D; Region: type_II_gspD; TIGR02517 1114970011949 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1114970011950 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1114970011951 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1114970011952 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1114970011953 type II secretion system protein E; Region: type_II_gspE; TIGR02533 1114970011954 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1114970011955 Walker A motif; other site 1114970011956 ATP binding site [chemical binding]; other site 1114970011957 Walker B motif; other site 1114970011958 type II secretion system protein F; Region: GspF; TIGR02120 1114970011959 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1114970011960 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1114970011961 PBP superfamily domain; Region: PBP_like_2; cl17296 1114970011962 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1114970011963 Filamentous haemagglutinin family outer membrane protein; Region: DUF3739; pfam12545 1114970011964 CHASE4 domain; Region: CHASE4; pfam05228 1114970011965 PAS domain S-box; Region: sensory_box; TIGR00229 1114970011966 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970011967 putative active site [active] 1114970011968 heme pocket [chemical binding]; other site 1114970011969 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114970011970 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970011971 metal binding site [ion binding]; metal-binding site 1114970011972 active site 1114970011973 I-site; other site 1114970011974 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970011975 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 1114970011976 thiamine pyrophosphate protein; Provisional; Region: PRK08273 1114970011977 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1114970011978 PYR/PP interface [polypeptide binding]; other site 1114970011979 dimer interface [polypeptide binding]; other site 1114970011980 tetramer interface [polypeptide binding]; other site 1114970011981 TPP binding site [chemical binding]; other site 1114970011982 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1114970011983 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1114970011984 TPP-binding site [chemical binding]; other site 1114970011985 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 1114970011986 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114970011987 HAMP domain; Region: HAMP; pfam00672 1114970011988 dimerization interface [polypeptide binding]; other site 1114970011989 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1114970011990 dimer interface [polypeptide binding]; other site 1114970011991 phosphorylation site [posttranslational modification] 1114970011992 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970011993 ATP binding site [chemical binding]; other site 1114970011994 Mg2+ binding site [ion binding]; other site 1114970011995 G-X-G motif; other site 1114970011996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970011997 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1114970011998 active site 1114970011999 phosphorylation site [posttranslational modification] 1114970012000 intermolecular recognition site; other site 1114970012001 dimerization interface [polypeptide binding]; other site 1114970012002 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970012003 DNA binding site [nucleotide binding] 1114970012004 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1114970012005 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1114970012006 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1114970012007 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1114970012008 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1114970012009 catalytic residues [active] 1114970012010 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1114970012011 PAS domain; Region: PAS; smart00091 1114970012012 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970012013 Walker A motif; other site 1114970012014 ATP binding site [chemical binding]; other site 1114970012015 Walker B motif; other site 1114970012016 arginine finger; other site 1114970012017 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1114970012018 DNA-binding interface [nucleotide binding]; DNA binding site 1114970012019 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 1114970012020 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1114970012021 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1114970012022 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1114970012023 tetramer interface [polypeptide binding]; other site 1114970012024 TPP-binding site [chemical binding]; other site 1114970012025 heterodimer interface [polypeptide binding]; other site 1114970012026 phosphorylation loop region [posttranslational modification] 1114970012027 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1114970012028 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1114970012029 alpha subunit interface [polypeptide binding]; other site 1114970012030 TPP binding site [chemical binding]; other site 1114970012031 heterodimer interface [polypeptide binding]; other site 1114970012032 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1114970012033 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 1114970012034 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1114970012035 E3 interaction surface; other site 1114970012036 lipoyl attachment site [posttranslational modification]; other site 1114970012037 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1114970012038 catalytic site [active] 1114970012039 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1114970012040 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1114970012041 putative NAD(P) binding site [chemical binding]; other site 1114970012042 catalytic Zn binding site [ion binding]; other site 1114970012043 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 1114970012044 DinB superfamily; Region: DinB_2; pfam12867 1114970012045 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1114970012046 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1114970012047 inhibitor site; inhibition site 1114970012048 active site 1114970012049 dimer interface [polypeptide binding]; other site 1114970012050 catalytic residue [active] 1114970012051 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 1114970012052 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1114970012053 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1114970012054 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1114970012055 Walker A/P-loop; other site 1114970012056 ATP binding site [chemical binding]; other site 1114970012057 Q-loop/lid; other site 1114970012058 ABC transporter signature motif; other site 1114970012059 Walker B; other site 1114970012060 D-loop; other site 1114970012061 H-loop/switch region; other site 1114970012062 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114970012063 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970012064 dimer interface [polypeptide binding]; other site 1114970012065 conserved gate region; other site 1114970012066 putative PBP binding loops; other site 1114970012067 ABC-ATPase subunit interface; other site 1114970012068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970012069 dimer interface [polypeptide binding]; other site 1114970012070 conserved gate region; other site 1114970012071 putative PBP binding loops; other site 1114970012072 ABC-ATPase subunit interface; other site 1114970012073 Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure...; Region: AcnX_swivel; cd01356 1114970012074 substrate binding site [chemical binding]; other site 1114970012075 Protein of unknown function (DUF521); Region: DUF521; pfam04412 1114970012076 Putative Aconitase X catalytic domain; Region: AcnX; cd01355 1114970012077 substrate binding site [chemical binding]; other site 1114970012078 ligand binding site [chemical binding]; other site 1114970012079 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970012080 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970012081 substrate binding pocket [chemical binding]; other site 1114970012082 membrane-bound complex binding site; other site 1114970012083 hinge residues; other site 1114970012084 PAS fold; Region: PAS_4; pfam08448 1114970012085 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1114970012086 putative active site [active] 1114970012087 heme pocket [chemical binding]; other site 1114970012088 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1114970012089 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970012090 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1114970012091 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1114970012092 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1114970012093 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 1114970012094 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1114970012095 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1114970012096 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970012097 DNA-binding site [nucleotide binding]; DNA binding site 1114970012098 FCD domain; Region: FCD; pfam07729 1114970012099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970012100 putative substrate translocation pore; other site 1114970012101 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970012102 DNA-binding site [nucleotide binding]; DNA binding site 1114970012103 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1114970012104 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970012105 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970012106 homodimer interface [polypeptide binding]; other site 1114970012107 catalytic residue [active] 1114970012108 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1114970012109 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970012110 N-terminal plug; other site 1114970012111 ligand-binding site [chemical binding]; other site 1114970012112 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1114970012113 classical (c) SDRs; Region: SDR_c; cd05233 1114970012114 NAD(P) binding site [chemical binding]; other site 1114970012115 active site 1114970012116 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 1114970012117 active site 1 [active] 1114970012118 dimer interface [polypeptide binding]; other site 1114970012119 hexamer interface [polypeptide binding]; other site 1114970012120 active site 2 [active] 1114970012121 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970012122 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970012123 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1114970012124 putative effector binding pocket; other site 1114970012125 dimerization interface [polypeptide binding]; other site 1114970012126 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1114970012127 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1114970012128 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970012129 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447 1114970012130 putative dimerization interface [polypeptide binding]; other site 1114970012131 putative substrate binding pocket [chemical binding]; other site 1114970012132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970012133 D-galactonate transporter; Region: 2A0114; TIGR00893 1114970012134 putative substrate translocation pore; other site 1114970012135 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1114970012136 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1114970012137 active site 1114970012138 tetramer interface [polypeptide binding]; other site 1114970012139 Gram-negative porin; Region: Porin_4; pfam13609 1114970012140 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1114970012141 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1114970012142 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 1114970012143 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1114970012144 structural tetrad; other site 1114970012145 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1114970012146 active site 1114970012147 SAM binding site [chemical binding]; other site 1114970012148 homodimer interface [polypeptide binding]; other site 1114970012149 heme d1 biosynthesis radical SAM protein NirJ; Region: rSAM_NirJ; TIGR04051 1114970012150 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114970012151 FeS/SAM binding site; other site 1114970012152 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1114970012153 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 1114970012154 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1114970012155 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1114970012156 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1114970012157 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1114970012158 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 1114970012159 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1114970012160 Cytochrome c; Region: Cytochrom_C; cl11414 1114970012161 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1114970012162 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1114970012163 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 1114970012164 MoxR-like ATPases [General function prediction only]; Region: COG0714 1114970012165 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970012166 Walker A motif; other site 1114970012167 ATP binding site [chemical binding]; other site 1114970012168 Walker B motif; other site 1114970012169 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1114970012170 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 1114970012171 Subunit I/III interface [polypeptide binding]; other site 1114970012172 Cytochrome c; Region: Cytochrom_C; pfam00034 1114970012173 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1114970012174 Low-spin heme binding site [chemical binding]; other site 1114970012175 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1114970012176 D-pathway; other site 1114970012177 Binuclear center (active site) [active] 1114970012178 K-pathway; other site 1114970012179 Putative proton exit pathway; other site 1114970012180 Putative water exit pathway; other site 1114970012181 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1114970012182 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1114970012183 metal ion-dependent adhesion site (MIDAS); other site 1114970012184 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1114970012185 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 1114970012186 ligand binding site [chemical binding]; other site 1114970012187 flexible hinge region; other site 1114970012188 putative switch regulator; other site 1114970012189 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1114970012190 non-specific DNA interactions [nucleotide binding]; other site 1114970012191 DNA binding site [nucleotide binding] 1114970012192 sequence specific DNA binding site [nucleotide binding]; other site 1114970012193 putative cAMP binding site [chemical binding]; other site 1114970012194 NnrS protein; Region: NnrS; pfam05940 1114970012195 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3399 1114970012196 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 1114970012197 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1114970012198 Hemerythrin-like domain; Region: Hr-like; cd12108 1114970012199 Fe binding site [ion binding]; other site 1114970012200 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 1114970012201 GAF domain; Region: GAF; pfam01590 1114970012202 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970012203 Walker A motif; other site 1114970012204 ATP binding site [chemical binding]; other site 1114970012205 Walker B motif; other site 1114970012206 arginine finger; other site 1114970012207 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 1114970012208 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1114970012209 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1114970012210 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1114970012211 MPT binding site; other site 1114970012212 trimer interface [polypeptide binding]; other site 1114970012213 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1114970012214 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1114970012215 dimer interface [polypeptide binding]; other site 1114970012216 putative functional site; other site 1114970012217 putative MPT binding site; other site 1114970012218 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1114970012219 Peptidase family U32; Region: Peptidase_U32; pfam01136 1114970012220 putative protease; Provisional; Region: PRK15447 1114970012221 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1114970012222 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 1114970012223 DGC domain; Region: DGC; pfam08859 1114970012224 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1114970012225 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1114970012226 ligand binding site [chemical binding]; other site 1114970012227 flexible hinge region; other site 1114970012228 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1114970012229 putative switch regulator; other site 1114970012230 non-specific DNA interactions [nucleotide binding]; other site 1114970012231 DNA binding site [nucleotide binding] 1114970012232 sequence specific DNA binding site [nucleotide binding]; other site 1114970012233 putative cAMP binding site [chemical binding]; other site 1114970012234 transcriptional regulator NarL; Provisional; Region: PRK10651 1114970012235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970012236 active site 1114970012237 phosphorylation site [posttranslational modification] 1114970012238 intermolecular recognition site; other site 1114970012239 dimerization interface [polypeptide binding]; other site 1114970012240 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970012241 DNA binding residues [nucleotide binding] 1114970012242 dimerization interface [polypeptide binding]; other site 1114970012243 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 1114970012244 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1114970012245 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970012246 dimerization interface [polypeptide binding]; other site 1114970012247 Histidine kinase; Region: HisKA_3; pfam07730 1114970012248 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970012249 ATP binding site [chemical binding]; other site 1114970012250 Mg2+ binding site [ion binding]; other site 1114970012251 G-X-G motif; other site 1114970012252 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1114970012253 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970012254 putative substrate translocation pore; other site 1114970012255 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1114970012256 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970012257 putative substrate translocation pore; other site 1114970012258 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 1114970012259 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1114970012260 [4Fe-4S] binding site [ion binding]; other site 1114970012261 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1114970012262 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1114970012263 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1114970012264 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1114970012265 molybdopterin cofactor binding site; other site 1114970012266 nitrate reductase, beta subunit; Region: narH; TIGR01660 1114970012267 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1114970012268 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1114970012269 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1114970012270 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 1114970012271 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114970012272 FeS/SAM binding site; other site 1114970012273 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1114970012274 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 1114970012275 ATP cone domain; Region: ATP-cone; pfam03477 1114970012276 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1114970012277 effector binding site; other site 1114970012278 active site 1114970012279 Zn binding site [ion binding]; other site 1114970012280 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 1114970012281 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 1114970012282 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114970012283 FeS/SAM binding site; other site 1114970012284 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1114970012285 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970012286 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970012287 dimer interface [polypeptide binding]; other site 1114970012288 putative CheW interface [polypeptide binding]; other site 1114970012289 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1114970012290 Iron permease FTR1 family; Region: FTR1; cl00475 1114970012291 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1114970012292 Fe2+ transport protein; Region: Iron_transport; pfam10634 1114970012293 Protein of unknown function (DUF3079); Region: DUF3079; pfam11278 1114970012294 hypothetical protein; Provisional; Region: PRK06156 1114970012295 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1114970012296 active site 1114970012297 metal binding site [ion binding]; metal-binding site 1114970012298 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1114970012299 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1114970012300 Peptidase family U32; Region: Peptidase_U32; pfam01136 1114970012301 Collagenase; Region: DUF3656; pfam12392 1114970012302 Cache domain; Region: Cache_1; pfam02743 1114970012303 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114970012304 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970012305 metal binding site [ion binding]; metal-binding site 1114970012306 active site 1114970012307 I-site; other site 1114970012308 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1114970012309 active site 1114970012310 metal binding site [ion binding]; metal-binding site 1114970012311 homotetramer interface [polypeptide binding]; other site 1114970012312 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 1114970012313 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 1114970012314 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1114970012315 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970012316 S-adenosylmethionine binding site [chemical binding]; other site 1114970012317 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 1114970012318 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 1114970012319 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1114970012320 short chain dehydrogenase; Provisional; Region: PRK06101 1114970012321 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970012322 NAD(P) binding site [chemical binding]; other site 1114970012323 active site 1114970012324 SnoaL-like domain; Region: SnoaL_2; pfam12680 1114970012325 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1114970012326 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1114970012327 FMN binding site [chemical binding]; other site 1114970012328 active site 1114970012329 substrate binding site [chemical binding]; other site 1114970012330 catalytic residue [active] 1114970012331 Pirin-related protein [General function prediction only]; Region: COG1741 1114970012332 Pirin; Region: Pirin; pfam02678 1114970012333 LysR family transcriptional regulator; Provisional; Region: PRK14997 1114970012334 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970012335 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1114970012336 putative effector binding pocket; other site 1114970012337 dimerization interface [polypeptide binding]; other site 1114970012338 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 1114970012339 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1114970012340 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1114970012341 homotrimer interaction site [polypeptide binding]; other site 1114970012342 putative active site [active] 1114970012343 Uncharacterized conserved protein [Function unknown]; Region: COG3342 1114970012344 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 1114970012345 acetylornithine deacetylase; Provisional; Region: PRK07522 1114970012346 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1114970012347 metal binding site [ion binding]; metal-binding site 1114970012348 putative dimer interface [polypeptide binding]; other site 1114970012349 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1114970012350 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1114970012351 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970012352 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970012353 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 1114970012354 putative substrate binding pocket [chemical binding]; other site 1114970012355 dimerization interface [polypeptide binding]; other site 1114970012356 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1114970012357 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114970012358 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970012359 intermolecular recognition site; other site 1114970012360 active site 1114970012361 dimerization interface [polypeptide binding]; other site 1114970012362 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1114970012363 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970012364 active site 1114970012365 phosphorylation site [posttranslational modification] 1114970012366 intermolecular recognition site; other site 1114970012367 dimerization interface [polypeptide binding]; other site 1114970012368 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970012369 DNA binding residues [nucleotide binding] 1114970012370 dimerization interface [polypeptide binding]; other site 1114970012371 PAS fold; Region: PAS; pfam00989 1114970012372 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970012373 dimer interface [polypeptide binding]; other site 1114970012374 phosphorylation site [posttranslational modification] 1114970012375 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970012376 ATP binding site [chemical binding]; other site 1114970012377 G-X-G motif; other site 1114970012378 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1114970012379 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970012380 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970012381 dimerization interface [polypeptide binding]; other site 1114970012382 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1114970012383 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1114970012384 conserved cys residue [active] 1114970012385 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970012386 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970012387 Helix-turn-helix domain; Region: HTH_18; pfam12833 1114970012388 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970012389 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 1114970012390 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970012391 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970012392 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1114970012393 Amidase; Region: Amidase; pfam01425 1114970012394 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1114970012395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970012396 dimer interface [polypeptide binding]; other site 1114970012397 conserved gate region; other site 1114970012398 putative PBP binding loops; other site 1114970012399 ABC-ATPase subunit interface; other site 1114970012400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970012401 dimer interface [polypeptide binding]; other site 1114970012402 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 1114970012403 conserved gate region; other site 1114970012404 putative PBP binding loops; other site 1114970012405 ABC-ATPase subunit interface; other site 1114970012406 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1114970012407 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114970012408 Walker A/P-loop; other site 1114970012409 ATP binding site [chemical binding]; other site 1114970012410 Q-loop/lid; other site 1114970012411 ABC transporter signature motif; other site 1114970012412 Walker B; other site 1114970012413 D-loop; other site 1114970012414 H-loop/switch region; other site 1114970012415 phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098 1114970012416 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970012417 substrate binding pocket [chemical binding]; other site 1114970012418 membrane-bound complex binding site; other site 1114970012419 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1114970012420 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1114970012421 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1114970012422 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1114970012423 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1114970012424 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 1114970012425 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 1114970012426 dimer interface [polypeptide binding]; other site 1114970012427 active site 1114970012428 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1114970012429 catalytic residues [active] 1114970012430 substrate binding site [chemical binding]; other site 1114970012431 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1114970012432 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1114970012433 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1114970012434 MULE transposase domain; Region: MULE; pfam10551 1114970012435 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 1114970012436 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1114970012437 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 1114970012438 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1114970012439 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1114970012440 active site 1114970012441 catalytic residues [active] 1114970012442 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114970012443 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1114970012444 active site 1114970012445 catalytic tetrad [active] 1114970012446 DNA polymerase II; Reviewed; Region: PRK05762 1114970012447 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 1114970012448 active site 1114970012449 catalytic site [active] 1114970012450 substrate binding site [chemical binding]; other site 1114970012451 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 1114970012452 active site 1114970012453 metal-binding site 1114970012454 FOG: CBS domain [General function prediction only]; Region: COG0517 1114970012455 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1114970012456 Paraquat-inducible protein A; Region: PqiA; pfam04403 1114970012457 Paraquat-inducible protein A; Region: PqiA; pfam04403 1114970012458 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1114970012459 mce related protein; Region: MCE; pfam02470 1114970012460 mce related protein; Region: MCE; pfam02470 1114970012461 mce related protein; Region: MCE; pfam02470 1114970012462 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1114970012463 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1114970012464 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1114970012465 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1114970012466 dimer interface [polypeptide binding]; other site 1114970012467 N-terminal domain interface [polypeptide binding]; other site 1114970012468 substrate binding pocket (H-site) [chemical binding]; other site 1114970012469 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 1114970012470 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1114970012471 dimer interface [polypeptide binding]; other site 1114970012472 active site 1114970012473 Schiff base residues; other site 1114970012474 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1114970012475 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1114970012476 C-terminal domain interface [polypeptide binding]; other site 1114970012477 GSH binding site (G-site) [chemical binding]; other site 1114970012478 dimer interface [polypeptide binding]; other site 1114970012479 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 1114970012480 dimer interface [polypeptide binding]; other site 1114970012481 N-terminal domain interface [polypeptide binding]; other site 1114970012482 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 1114970012483 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 1114970012484 active site residue [active] 1114970012485 selenophosphate synthetase; Provisional; Region: PRK00943 1114970012486 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1114970012487 dimerization interface [polypeptide binding]; other site 1114970012488 putative ATP binding site [chemical binding]; other site 1114970012489 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 1114970012490 Purine nucleoside permease (NUP); Region: NUP; pfam06516 1114970012491 Predicted esterase [General function prediction only]; Region: COG0400 1114970012492 putative hydrolase; Provisional; Region: PRK11460 1114970012493 Predicted deacylase [General function prediction only]; Region: COG3608 1114970012494 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 1114970012495 active site 1114970012496 Zn binding site [ion binding]; other site 1114970012497 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1114970012498 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970012499 substrate binding pocket [chemical binding]; other site 1114970012500 membrane-bound complex binding site; other site 1114970012501 hinge residues; other site 1114970012502 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 1114970012503 active site residue [active] 1114970012504 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1114970012505 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1114970012506 conserved cys residue [active] 1114970012507 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970012508 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970012509 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 1114970012510 active site 1114970012511 SAM binding site [chemical binding]; other site 1114970012512 homodimer interface [polypeptide binding]; other site 1114970012513 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1114970012514 catalytic core [active] 1114970012515 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1114970012516 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1114970012517 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1114970012518 putative active site [active] 1114970012519 Isochorismatase family; Region: Isochorismatase; pfam00857 1114970012520 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1114970012521 catalytic triad [active] 1114970012522 conserved cis-peptide bond; other site 1114970012523 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1114970012524 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1114970012525 N-formylglutamate amidohydrolase; Region: FGase; cl01522 1114970012526 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1114970012527 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1114970012528 Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958 1114970012529 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1114970012530 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 1114970012531 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1114970012532 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1114970012533 tetramer interface [polypeptide binding]; other site 1114970012534 active site 1114970012535 Mg2+/Mn2+ binding site [ion binding]; other site 1114970012536 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1114970012537 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 1114970012538 FAD binding site [chemical binding]; other site 1114970012539 substrate binding site [chemical binding]; other site 1114970012540 catalytic base [active] 1114970012541 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1114970012542 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970012543 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1114970012544 substrate binding pocket [chemical binding]; other site 1114970012545 dimerization interface [polypeptide binding]; other site 1114970012546 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 1114970012547 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1114970012548 DNA binding residues [nucleotide binding] 1114970012549 putative dimer interface [polypeptide binding]; other site 1114970012550 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1114970012551 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1114970012552 active site 1114970012553 catalytic residues [active] 1114970012554 metal binding site [ion binding]; metal-binding site 1114970012555 AMP-binding domain protein; Validated; Region: PRK08315 1114970012556 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1114970012557 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1114970012558 acyl-activating enzyme (AAE) consensus motif; other site 1114970012559 putative AMP binding site [chemical binding]; other site 1114970012560 putative active site [active] 1114970012561 putative CoA binding site [chemical binding]; other site 1114970012562 isovaleryl-CoA dehydrogenase; Region: PLN02519 1114970012563 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 1114970012564 substrate binding site [chemical binding]; other site 1114970012565 FAD binding site [chemical binding]; other site 1114970012566 catalytic base [active] 1114970012567 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 1114970012568 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1114970012569 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1114970012570 gamma-carboxygeranoyl-CoA hydratase; Validated; Region: PRK05674 1114970012571 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114970012572 substrate binding site [chemical binding]; other site 1114970012573 oxyanion hole (OAH) forming residues; other site 1114970012574 trimer interface [polypeptide binding]; other site 1114970012575 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1114970012576 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1114970012577 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1114970012578 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1114970012579 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1114970012580 carboxyltransferase (CT) interaction site; other site 1114970012581 biotinylation site [posttranslational modification]; other site 1114970012582 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114970012583 non-specific DNA binding site [nucleotide binding]; other site 1114970012584 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1114970012585 salt bridge; other site 1114970012586 sequence-specific DNA binding site [nucleotide binding]; other site 1114970012587 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1114970012588 Catalytic site [active] 1114970012589 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1114970012590 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1114970012591 active site 1114970012592 Zn binding site [ion binding]; other site 1114970012593 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1114970012594 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 1114970012595 putative heme binding pocket [chemical binding]; other site 1114970012596 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 1114970012597 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970012598 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114970012599 DNA binding residues [nucleotide binding] 1114970012600 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1114970012601 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1114970012602 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114970012603 putative DNA binding site [nucleotide binding]; other site 1114970012604 putative Zn2+ binding site [ion binding]; other site 1114970012605 Bacterial transcriptional regulator; Region: IclR; pfam01614 1114970012606 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1114970012607 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114970012608 Walker A/P-loop; other site 1114970012609 ATP binding site [chemical binding]; other site 1114970012610 Q-loop/lid; other site 1114970012611 ABC transporter signature motif; other site 1114970012612 Walker B; other site 1114970012613 D-loop; other site 1114970012614 H-loop/switch region; other site 1114970012615 TOBE domain; Region: TOBE_2; pfam08402 1114970012616 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1114970012617 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970012618 dimer interface [polypeptide binding]; other site 1114970012619 conserved gate region; other site 1114970012620 putative PBP binding loops; other site 1114970012621 ABC-ATPase subunit interface; other site 1114970012622 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1114970012623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970012624 dimer interface [polypeptide binding]; other site 1114970012625 conserved gate region; other site 1114970012626 putative PBP binding loops; other site 1114970012627 ABC-ATPase subunit interface; other site 1114970012628 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1114970012629 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1114970012630 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1114970012631 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1114970012632 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1114970012633 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1114970012634 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1114970012635 Leucine rich repeat; Region: LRR_8; pfam13855 1114970012636 Leucine rich repeat; Region: LRR_8; pfam13855 1114970012637 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 1114970012638 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114970012639 active site 1114970012640 ATP binding site [chemical binding]; other site 1114970012641 substrate binding site [chemical binding]; other site 1114970012642 activation loop (A-loop); other site 1114970012643 hypothetical protein; Provisional; Region: PRK12378 1114970012644 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1114970012645 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 1114970012646 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1114970012647 D-cysteine desulfhydrase; Validated; Region: PRK03910 1114970012648 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1114970012649 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114970012650 catalytic residue [active] 1114970012651 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1114970012652 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1114970012653 active site 1114970012654 FMN binding site [chemical binding]; other site 1114970012655 2,4-decadienoyl-CoA binding site; other site 1114970012656 catalytic residue [active] 1114970012657 4Fe-4S cluster binding site [ion binding]; other site 1114970012658 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1114970012659 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1114970012660 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 1114970012661 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 1114970012662 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1114970012663 active site 1114970012664 catalytic triad [active] 1114970012665 dimer interface [polypeptide binding]; other site 1114970012666 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1114970012667 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114970012668 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970012669 Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001 1114970012670 periplasmic folding chaperone; Provisional; Region: PRK10788 1114970012671 SurA N-terminal domain; Region: SurA_N_3; pfam13624 1114970012672 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1114970012673 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1114970012674 IHF - DNA interface [nucleotide binding]; other site 1114970012675 IHF dimer interface [polypeptide binding]; other site 1114970012676 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1114970012677 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1114970012678 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970012679 Walker A motif; other site 1114970012680 ATP binding site [chemical binding]; other site 1114970012681 Walker B motif; other site 1114970012682 arginine finger; other site 1114970012683 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1114970012684 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1114970012685 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1114970012686 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970012687 Walker A motif; other site 1114970012688 ATP binding site [chemical binding]; other site 1114970012689 Walker B motif; other site 1114970012690 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1114970012691 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1114970012692 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1114970012693 oligomer interface [polypeptide binding]; other site 1114970012694 active site residues [active] 1114970012695 trigger factor; Provisional; Region: tig; PRK01490 1114970012696 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1114970012697 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1114970012698 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 1114970012699 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1114970012700 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1114970012701 homodimer interface [polypeptide binding]; other site 1114970012702 NADP binding site [chemical binding]; other site 1114970012703 substrate binding site [chemical binding]; other site 1114970012704 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 1114970012705 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1114970012706 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1114970012707 putative active site [active] 1114970012708 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1114970012709 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 1114970012710 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970012711 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 1114970012712 putative dimerization interface [polypeptide binding]; other site 1114970012713 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1114970012714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970012715 putative substrate translocation pore; other site 1114970012716 serine/threonine transporter SstT; Provisional; Region: PRK13628 1114970012717 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1114970012718 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 1114970012719 Protein of unknown function, DUF480; Region: DUF480; pfam04337 1114970012720 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 1114970012721 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1114970012722 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1114970012723 shikimate binding site; other site 1114970012724 NAD(P) binding site [chemical binding]; other site 1114970012725 xanthine permease; Region: pbuX; TIGR03173 1114970012726 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1114970012727 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1114970012728 putative catalytic site [active] 1114970012729 putative phosphate binding site [ion binding]; other site 1114970012730 active site 1114970012731 metal binding site A [ion binding]; metal-binding site 1114970012732 DNA binding site [nucleotide binding] 1114970012733 putative AP binding site [nucleotide binding]; other site 1114970012734 putative metal binding site B [ion binding]; other site 1114970012735 Cache domain; Region: Cache_1; pfam02743 1114970012736 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114970012737 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970012738 metal binding site [ion binding]; metal-binding site 1114970012739 active site 1114970012740 I-site; other site 1114970012741 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 1114970012742 B1 nucleotide binding pocket [chemical binding]; other site 1114970012743 B2 nucleotide binding pocket [chemical binding]; other site 1114970012744 CAS motifs; other site 1114970012745 active site 1114970012746 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1114970012747 Chromate transporter; Region: Chromate_transp; pfam02417 1114970012748 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1114970012749 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1114970012750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970012751 putative substrate translocation pore; other site 1114970012752 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1114970012753 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1114970012754 putative NAD(P) binding site [chemical binding]; other site 1114970012755 putative substrate binding site [chemical binding]; other site 1114970012756 catalytic Zn binding site [ion binding]; other site 1114970012757 structural Zn binding site [ion binding]; other site 1114970012758 dimer interface [polypeptide binding]; other site 1114970012759 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1114970012760 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1114970012761 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970012762 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177 1114970012763 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1114970012764 aspartate racemase; Region: asp_race; TIGR00035 1114970012765 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1114970012766 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1114970012767 cell density-dependent motility repressor; Provisional; Region: PRK10082 1114970012768 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970012769 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1114970012770 dimerization interface [polypeptide binding]; other site 1114970012771 Fic/DOC family; Region: Fic; cl00960 1114970012772 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 1114970012773 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 1114970012774 active site 1114970012775 metal binding site [ion binding]; metal-binding site 1114970012776 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1114970012777 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1114970012778 FMN binding site [chemical binding]; other site 1114970012779 active site 1114970012780 catalytic residues [active] 1114970012781 substrate binding site [chemical binding]; other site 1114970012782 transaldolase-like protein; Provisional; Region: PTZ00411 1114970012783 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1114970012784 active site 1114970012785 dimer interface [polypeptide binding]; other site 1114970012786 catalytic residue [active] 1114970012787 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1114970012788 anti sigma factor interaction site; other site 1114970012789 regulatory phosphorylation site [posttranslational modification]; other site 1114970012790 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970012791 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970012792 active site 1114970012793 phosphorylation site [posttranslational modification] 1114970012794 intermolecular recognition site; other site 1114970012795 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1114970012796 dimerization interface [polypeptide binding]; other site 1114970012797 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1114970012798 Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853 1114970012799 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 1114970012800 Domain of unknown function (DUF4404); Region: DUF4404; pfam14357 1114970012801 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 1114970012802 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 1114970012803 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1114970012804 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 1114970012805 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1114970012806 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970012807 active site 1114970012808 phosphorylation site [posttranslational modification] 1114970012809 intermolecular recognition site; other site 1114970012810 dimerization interface [polypeptide binding]; other site 1114970012811 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970012812 DNA binding site [nucleotide binding] 1114970012813 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1114970012814 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970012815 dimer interface [polypeptide binding]; other site 1114970012816 phosphorylation site [posttranslational modification] 1114970012817 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970012818 ATP binding site [chemical binding]; other site 1114970012819 Mg2+ binding site [ion binding]; other site 1114970012820 G-X-G motif; other site 1114970012821 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1114970012822 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1114970012823 FtsX-like permease family; Region: FtsX; pfam02687 1114970012824 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 1114970012825 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1114970012826 Walker A/P-loop; other site 1114970012827 ATP binding site [chemical binding]; other site 1114970012828 Q-loop/lid; other site 1114970012829 ABC transporter signature motif; other site 1114970012830 Walker B; other site 1114970012831 D-loop; other site 1114970012832 H-loop/switch region; other site 1114970012833 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1114970012834 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1114970012835 FtsX-like permease family; Region: FtsX; pfam02687 1114970012836 PilZ domain; Region: PilZ; pfam07238 1114970012837 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1114970012838 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1114970012839 active site 1114970012840 catalytic site [active] 1114970012841 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1114970012842 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114970012843 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1114970012844 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1114970012845 ApbE family; Region: ApbE; pfam02424 1114970012846 citrate-proton symporter; Provisional; Region: PRK15075 1114970012847 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970012848 putative substrate translocation pore; other site 1114970012849 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 1114970012850 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1114970012851 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1114970012852 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1114970012853 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1114970012854 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114970012855 ATP binding site [chemical binding]; other site 1114970012856 putative Mg++ binding site [ion binding]; other site 1114970012857 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114970012858 nucleotide binding region [chemical binding]; other site 1114970012859 ATP-binding site [chemical binding]; other site 1114970012860 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1114970012861 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 1114970012862 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1114970012863 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114970012864 ATP binding site [chemical binding]; other site 1114970012865 putative Mg++ binding site [ion binding]; other site 1114970012866 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114970012867 nucleotide binding region [chemical binding]; other site 1114970012868 ATP-binding site [chemical binding]; other site 1114970012869 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1114970012870 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114970012871 ATP binding site [chemical binding]; other site 1114970012872 putative Mg++ binding site [ion binding]; other site 1114970012873 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114970012874 nucleotide binding region [chemical binding]; other site 1114970012875 ATP-binding site [chemical binding]; other site 1114970012876 beta-hexosaminidase; Provisional; Region: PRK05337 1114970012877 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1114970012878 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970012879 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114970012880 Protein of unknown function (DUF3179); Region: DUF3179; pfam11376 1114970012881 LexA repressor; Validated; Region: PRK00215 1114970012882 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1114970012883 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1114970012884 Catalytic site [active] 1114970012885 Cell division inhibitor SulA; Region: SulA; cl01880 1114970012886 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1114970012887 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1114970012888 active site 1114970012889 interdomain interaction site; other site 1114970012890 putative metal-binding site [ion binding]; other site 1114970012891 nucleotide binding site [chemical binding]; other site 1114970012892 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1114970012893 domain I; other site 1114970012894 DNA binding groove [nucleotide binding] 1114970012895 phosphate binding site [ion binding]; other site 1114970012896 domain II; other site 1114970012897 domain III; other site 1114970012898 nucleotide binding site [chemical binding]; other site 1114970012899 catalytic site [active] 1114970012900 domain IV; other site 1114970012901 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1114970012902 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1114970012903 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1114970012904 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1114970012905 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 1114970012906 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 1114970012907 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1114970012908 dimer interface [polypeptide binding]; other site 1114970012909 active site 1114970012910 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1114970012911 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114970012912 substrate binding site [chemical binding]; other site 1114970012913 oxyanion hole (OAH) forming residues; other site 1114970012914 trimer interface [polypeptide binding]; other site 1114970012915 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1114970012916 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1114970012917 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1114970012918 Ligand Binding Site [chemical binding]; other site 1114970012919 ABC transporter ATPase component; Reviewed; Region: PRK11147 1114970012920 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1114970012921 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1114970012922 ABC transporter; Region: ABC_tran_2; pfam12848 1114970012923 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1114970012924 lytic murein transglycosylase; Provisional; Region: PRK11619 1114970012925 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1114970012926 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1114970012927 catalytic residue [active] 1114970012928 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 1114970012929 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1114970012930 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114970012931 Walker A/P-loop; other site 1114970012932 ATP binding site [chemical binding]; other site 1114970012933 Q-loop/lid; other site 1114970012934 ABC transporter signature motif; other site 1114970012935 Walker B; other site 1114970012936 D-loop; other site 1114970012937 H-loop/switch region; other site 1114970012938 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 1114970012939 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 1114970012940 ligand binding site [chemical binding]; other site 1114970012941 NAD binding site [chemical binding]; other site 1114970012942 catalytic site [active] 1114970012943 homodimer interface [polypeptide binding]; other site 1114970012944 multidrug efflux protein; Reviewed; Region: PRK01766 1114970012945 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1114970012946 cation binding site [ion binding]; other site 1114970012947 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 1114970012948 CPxP motif; other site 1114970012949 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 1114970012950 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1114970012951 aconitate hydratase; Validated; Region: PRK09277 1114970012952 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1114970012953 substrate binding site [chemical binding]; other site 1114970012954 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1114970012955 ligand binding site [chemical binding]; other site 1114970012956 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1114970012957 substrate binding site [chemical binding]; other site 1114970012958 CAAX protease self-immunity; Region: Abi; pfam02517 1114970012959 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970012960 PAS domain; Region: PAS_9; pfam13426 1114970012961 putative active site [active] 1114970012962 heme pocket [chemical binding]; other site 1114970012963 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970012964 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970012965 dimer interface [polypeptide binding]; other site 1114970012966 putative CheW interface [polypeptide binding]; other site 1114970012967 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 1114970012968 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 1114970012969 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1114970012970 Low-spin heme binding site [chemical binding]; other site 1114970012971 Putative water exit pathway; other site 1114970012972 Binuclear center (active site) [active] 1114970012973 Putative proton exit pathway; other site 1114970012974 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 1114970012975 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 1114970012976 Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545 1114970012977 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 1114970012978 Cytochrome c; Region: Cytochrom_C; pfam00034 1114970012979 Cytochrome c; Region: Cytochrom_C; cl11414 1114970012980 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 1114970012981 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1114970012982 Low-spin heme binding site [chemical binding]; other site 1114970012983 Putative water exit pathway; other site 1114970012984 Binuclear center (active site) [active] 1114970012985 Putative proton exit pathway; other site 1114970012986 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 1114970012987 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 1114970012988 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 1114970012989 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 1114970012990 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1114970012991 Cytochrome c; Region: Cytochrom_C; pfam00034 1114970012992 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 1114970012993 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1114970012994 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1114970012995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198 1114970012996 FixH; Region: FixH; pfam05751 1114970012997 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 1114970012998 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1114970012999 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1114970013000 metal-binding site [ion binding] 1114970013001 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1114970013002 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114970013003 motif II; other site 1114970013004 Uncharacterized protein, possibly involved in nitrogen fixation [Inorganic ion transport and metabolism]; Region: FixS; COG3197 1114970013005 Uncharacterized conserved protein [Function unknown]; Region: COG2836 1114970013006 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1114970013007 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114970013008 FeS/SAM binding site; other site 1114970013009 HemN C-terminal domain; Region: HemN_C; pfam06969 1114970013010 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1114970013011 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1114970013012 ligand binding site [chemical binding]; other site 1114970013013 flexible hinge region; other site 1114970013014 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1114970013015 putative switch regulator; other site 1114970013016 non-specific DNA interactions [nucleotide binding]; other site 1114970013017 DNA binding site [nucleotide binding] 1114970013018 sequence specific DNA binding site [nucleotide binding]; other site 1114970013019 putative cAMP binding site [chemical binding]; other site 1114970013020 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114970013021 active site 1114970013022 recombination protein RecR; Reviewed; Region: recR; PRK00076 1114970013023 RecR protein; Region: RecR; pfam02132 1114970013024 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1114970013025 putative active site [active] 1114970013026 putative metal-binding site [ion binding]; other site 1114970013027 tetramer interface [polypeptide binding]; other site 1114970013028 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1114970013029 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1114970013030 NAD(P) binding site [chemical binding]; other site 1114970013031 substrate binding site [chemical binding]; other site 1114970013032 dimer interface [polypeptide binding]; other site 1114970013033 hypothetical protein; Validated; Region: PRK00153 1114970013034 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1114970013035 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970013036 Walker A motif; other site 1114970013037 ATP binding site [chemical binding]; other site 1114970013038 Walker B motif; other site 1114970013039 arginine finger; other site 1114970013040 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1114970013041 PAS domain; Region: PAS_9; pfam13426 1114970013042 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970013043 putative active site [active] 1114970013044 heme pocket [chemical binding]; other site 1114970013045 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114970013046 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970013047 metal binding site [ion binding]; metal-binding site 1114970013048 active site 1114970013049 I-site; other site 1114970013050 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970013051 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114970013052 non-specific DNA binding site [nucleotide binding]; other site 1114970013053 salt bridge; other site 1114970013054 sequence-specific DNA binding site [nucleotide binding]; other site 1114970013055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 1114970013056 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 1114970013057 Ligase N family; Region: LIGANc; smart00532 1114970013058 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1114970013059 nucleotide binding pocket [chemical binding]; other site 1114970013060 K-X-D-G motif; other site 1114970013061 catalytic site [active] 1114970013062 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1114970013063 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1114970013064 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 1114970013065 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1114970013066 Dimer interface [polypeptide binding]; other site 1114970013067 cell division protein ZipA; Reviewed; Region: zipA; PRK00269 1114970013068 Cell division protein [Cell division and chromosome partitioning]; Region: ZipA; COG3115 1114970013069 FtsZ protein binding site [polypeptide binding]; other site 1114970013070 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1114970013071 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1114970013072 Walker A/P-loop; other site 1114970013073 ATP binding site [chemical binding]; other site 1114970013074 Q-loop/lid; other site 1114970013075 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1114970013076 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 1114970013077 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1114970013078 ABC transporter signature motif; other site 1114970013079 Walker B; other site 1114970013080 D-loop; other site 1114970013081 H-loop/switch region; other site 1114970013082 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1114970013083 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970013084 DNA-binding site [nucleotide binding]; DNA binding site 1114970013085 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 1114970013086 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1114970013087 catalytic loop [active] 1114970013088 iron binding site [ion binding]; other site 1114970013089 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1114970013090 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1114970013091 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 1114970013092 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1114970013093 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1114970013094 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1114970013095 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 1114970013096 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1114970013097 guanine deaminase; Provisional; Region: PRK09228 1114970013098 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 1114970013099 active site 1114970013100 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1114970013101 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970013102 DNA-binding site [nucleotide binding]; DNA binding site 1114970013103 FCD domain; Region: FCD; pfam07729 1114970013104 benzoate transporter; Region: benE; TIGR00843 1114970013105 Benzoate membrane transport protein; Region: BenE; pfam03594 1114970013106 Protein with unknown function (DUF469); Region: DUF469; cl01237 1114970013107 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 1114970013108 CHASE domain; Region: CHASE; pfam03924 1114970013109 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970013110 PAS domain; Region: PAS_9; pfam13426 1114970013111 putative active site [active] 1114970013112 heme pocket [chemical binding]; other site 1114970013113 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970013114 PAS fold; Region: PAS_3; pfam08447 1114970013115 putative active site [active] 1114970013116 heme pocket [chemical binding]; other site 1114970013117 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114970013118 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970013119 metal binding site [ion binding]; metal-binding site 1114970013120 active site 1114970013121 I-site; other site 1114970013122 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 1114970013123 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1114970013124 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1114970013125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970013126 S-adenosylmethionine binding site [chemical binding]; other site 1114970013127 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1114970013128 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1114970013129 quinone interaction residues [chemical binding]; other site 1114970013130 active site 1114970013131 catalytic residues [active] 1114970013132 FMN binding site [chemical binding]; other site 1114970013133 substrate binding site [chemical binding]; other site 1114970013134 Integrase core domain; Region: rve_3; cl15866 1114970013135 Transposase; Region: HTH_Tnp_1; pfam01527 1114970013136 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1114970013137 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1114970013138 putative dimer interface [polypeptide binding]; other site 1114970013139 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114970013140 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1114970013141 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 1114970013142 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1114970013143 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1114970013144 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1114970013145 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1114970013146 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1114970013147 metal binding site [ion binding]; metal-binding site 1114970013148 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1114970013149 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1114970013150 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1114970013151 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114970013152 ABC-ATPase subunit interface; other site 1114970013153 dimer interface [polypeptide binding]; other site 1114970013154 putative PBP binding regions; other site 1114970013155 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1114970013156 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1114970013157 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 1114970013158 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 1114970013159 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1114970013160 substrate binding site [chemical binding]; other site 1114970013161 ligand binding site [chemical binding]; other site 1114970013162 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 1114970013163 substrate binding site [chemical binding]; other site 1114970013164 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1114970013165 Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108 1114970013166 dimer interface [polypeptide binding]; other site 1114970013167 active site 1114970013168 citrylCoA binding site [chemical binding]; other site 1114970013169 oxalacetate/citrate binding site [chemical binding]; other site 1114970013170 coenzyme A binding site [chemical binding]; other site 1114970013171 catalytic triad [active] 1114970013172 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1114970013173 tetramer interface [polypeptide binding]; other site 1114970013174 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1114970013175 active site 1114970013176 Mg2+/Mn2+ binding site [ion binding]; other site 1114970013177 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1114970013178 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970013179 DNA-binding site [nucleotide binding]; DNA binding site 1114970013180 FCD domain; Region: FCD; pfam07729 1114970013181 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 1114970013182 Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400 1114970013183 7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402 1114970013184 alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291 1114970013185 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1114970013186 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1114970013187 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1114970013188 phosphoserine phosphatase; Provisional; Region: thrH; PRK13582 1114970013189 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1114970013190 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1114970013191 Active Sites [active] 1114970013192 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 1114970013193 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1114970013194 Na binding site [ion binding]; other site 1114970013195 putative substrate binding site [chemical binding]; other site 1114970013196 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1114970013197 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970013198 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970013199 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1114970013200 putative effector binding pocket; other site 1114970013201 dimerization interface [polypeptide binding]; other site 1114970013202 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970013203 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1114970013204 NAD(P) binding site [chemical binding]; other site 1114970013205 active site 1114970013206 hydrolase; Region: PLN02811 1114970013207 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114970013208 motif II; other site 1114970013209 PAS fold; Region: PAS_4; pfam08448 1114970013210 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1114970013211 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1114970013212 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970013213 dimer interface [polypeptide binding]; other site 1114970013214 phosphorylation site [posttranslational modification] 1114970013215 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970013216 ATP binding site [chemical binding]; other site 1114970013217 Mg2+ binding site [ion binding]; other site 1114970013218 G-X-G motif; other site 1114970013219 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970013220 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970013221 active site 1114970013222 phosphorylation site [posttranslational modification] 1114970013223 intermolecular recognition site; other site 1114970013224 dimerization interface [polypeptide binding]; other site 1114970013225 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 1114970013226 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114970013227 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1114970013228 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1114970013229 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1114970013230 putative DNA binding site [nucleotide binding]; other site 1114970013231 putative Zn2+ binding site [ion binding]; other site 1114970013232 AsnC family; Region: AsnC_trans_reg; pfam01037 1114970013233 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 1114970013234 hypothetical protein; Validated; Region: PRK06217 1114970013235 Beta-lactamase; Region: Beta-lactamase; pfam00144 1114970013236 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1114970013237 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1114970013238 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114970013239 Transcriptional activator HlyU; Region: HlyU; cl02273 1114970013240 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1114970013241 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1114970013242 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1114970013243 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970013244 Coenzyme A binding pocket [chemical binding]; other site 1114970013245 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1114970013246 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1114970013247 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1114970013248 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114970013249 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1114970013250 active site 1114970013251 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1114970013252 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 1114970013253 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 1114970013254 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1114970013255 Dimer interface [polypeptide binding]; other site 1114970013256 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114970013257 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970013258 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 1114970013259 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1114970013260 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1114970013261 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114970013262 substrate binding site [chemical binding]; other site 1114970013263 oxyanion hole (OAH) forming residues; other site 1114970013264 trimer interface [polypeptide binding]; other site 1114970013265 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1114970013266 putative acyl-acceptor binding pocket; other site 1114970013267 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1114970013268 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1114970013269 oligomer interface [polypeptide binding]; other site 1114970013270 metal binding site [ion binding]; metal-binding site 1114970013271 metal binding site [ion binding]; metal-binding site 1114970013272 putative Cl binding site [ion binding]; other site 1114970013273 basic sphincter; other site 1114970013274 hydrophobic gate; other site 1114970013275 periplasmic entrance; other site 1114970013276 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1114970013277 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1114970013278 catalytic triad [active] 1114970013279 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1114970013280 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114970013281 substrate binding site [chemical binding]; other site 1114970013282 oxyanion hole (OAH) forming residues; other site 1114970013283 trimer interface [polypeptide binding]; other site 1114970013284 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1114970013285 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1114970013286 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1114970013287 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1114970013288 dimer interface [polypeptide binding]; other site 1114970013289 active site 1114970013290 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1114970013291 Cytochrome c; Region: Cytochrom_C; pfam00034 1114970013292 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1114970013293 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1114970013294 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1114970013295 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1114970013296 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1114970013297 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1114970013298 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 1114970013299 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876 1114970013300 putative lipid binding site [chemical binding]; other site 1114970013301 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1114970013302 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970013303 DNA-binding site [nucleotide binding]; DNA binding site 1114970013304 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970013305 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970013306 homodimer interface [polypeptide binding]; other site 1114970013307 catalytic residue [active] 1114970013308 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1114970013309 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1114970013310 ligand binding site [chemical binding]; other site 1114970013311 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 1114970013312 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970013313 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970013314 substrate binding pocket [chemical binding]; other site 1114970013315 membrane-bound complex binding site; other site 1114970013316 hinge residues; other site 1114970013317 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1114970013318 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1114970013319 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1114970013320 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1114970013321 Ligand binding site [chemical binding]; other site 1114970013322 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1114970013323 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1114970013324 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1114970013325 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 1114970013326 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1114970013327 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1114970013328 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970013329 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970013330 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1114970013331 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1114970013332 putative NAD(P) binding site [chemical binding]; other site 1114970013333 putative substrate binding site [chemical binding]; other site 1114970013334 catalytic Zn binding site [ion binding]; other site 1114970013335 structural Zn binding site [ion binding]; other site 1114970013336 dimer interface [polypeptide binding]; other site 1114970013337 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1114970013338 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1114970013339 Bacterial transcriptional regulator; Region: IclR; pfam01614 1114970013340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970013341 D-galactonate transporter; Region: 2A0114; TIGR00893 1114970013342 putative substrate translocation pore; other site 1114970013343 galactonate dehydratase; Provisional; Region: PRK14017 1114970013344 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 1114970013345 putative active site pocket [active] 1114970013346 putative metal binding site [ion binding]; other site 1114970013347 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 1114970013348 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1114970013349 active site 1114970013350 intersubunit interface [polypeptide binding]; other site 1114970013351 catalytic residue [active] 1114970013352 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 1114970013353 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 1114970013354 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1114970013355 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1114970013356 putative C-terminal domain interface [polypeptide binding]; other site 1114970013357 putative GSH binding site (G-site) [chemical binding]; other site 1114970013358 putative dimer interface [polypeptide binding]; other site 1114970013359 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1114970013360 putative N-terminal domain interface [polypeptide binding]; other site 1114970013361 putative dimer interface [polypeptide binding]; other site 1114970013362 putative substrate binding pocket (H-site) [chemical binding]; other site 1114970013363 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1114970013364 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970013365 Coenzyme A binding pocket [chemical binding]; other site 1114970013366 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 1114970013367 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1114970013368 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1114970013369 TM-ABC transporter signature motif; other site 1114970013370 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 1114970013371 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1114970013372 Walker A/P-loop; other site 1114970013373 ATP binding site [chemical binding]; other site 1114970013374 Q-loop/lid; other site 1114970013375 ABC transporter signature motif; other site 1114970013376 Walker B; other site 1114970013377 D-loop; other site 1114970013378 H-loop/switch region; other site 1114970013379 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1114970013380 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1114970013381 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 1114970013382 ligand binding site [chemical binding]; other site 1114970013383 short chain dehydrogenase; Provisional; Region: PRK07063 1114970013384 classical (c) SDRs; Region: SDR_c; cd05233 1114970013385 NAD(P) binding site [chemical binding]; other site 1114970013386 active site 1114970013387 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1114970013388 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1114970013389 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970013390 DNA-binding site [nucleotide binding]; DNA binding site 1114970013391 FCD domain; Region: FCD; pfam07729 1114970013392 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816 1114970013393 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 1114970013394 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1114970013395 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114970013396 FeS/SAM binding site; other site 1114970013397 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1114970013398 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970013399 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114970013400 WHG domain; Region: WHG; pfam13305 1114970013401 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1114970013402 active site 1114970013403 PilZ domain; Region: PilZ; cl01260 1114970013404 DNA polymerase III subunit delta'; Validated; Region: PRK05707 1114970013405 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1114970013406 thymidylate kinase; Validated; Region: tmk; PRK00698 1114970013407 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1114970013408 TMP-binding site; other site 1114970013409 ATP-binding site [chemical binding]; other site 1114970013410 YceG-like family; Region: YceG; pfam02618 1114970013411 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1114970013412 dimerization interface [polypeptide binding]; other site 1114970013413 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1114970013414 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1114970013415 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970013416 catalytic residue [active] 1114970013417 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1114970013418 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1114970013419 dimer interface [polypeptide binding]; other site 1114970013420 active site 1114970013421 acyl carrier protein; Provisional; Region: acpP; PRK00982 1114970013422 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1114970013423 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1114970013424 NAD(P) binding site [chemical binding]; other site 1114970013425 homotetramer interface [polypeptide binding]; other site 1114970013426 homodimer interface [polypeptide binding]; other site 1114970013427 active site 1114970013428 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1114970013429 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1114970013430 putative phosphate acyltransferase; Provisional; Region: PRK05331 1114970013431 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1114970013432 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1114970013433 Maf-like protein; Region: Maf; pfam02545 1114970013434 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1114970013435 active site 1114970013436 dimer interface [polypeptide binding]; other site 1114970013437 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 1114970013438 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1114970013439 tandem repeat interface [polypeptide binding]; other site 1114970013440 oligomer interface [polypeptide binding]; other site 1114970013441 active site residues [active] 1114970013442 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1114970013443 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114970013444 motif II; other site 1114970013445 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1114970013446 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1114970013447 RNA binding surface [nucleotide binding]; other site 1114970013448 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1114970013449 active site 1114970013450 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 1114970013451 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1114970013452 homodimer interface [polypeptide binding]; other site 1114970013453 oligonucleotide binding site [chemical binding]; other site 1114970013454 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1114970013455 Ligand binding site; other site 1114970013456 metal-binding site 1114970013457 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1114970013458 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1114970013459 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1114970013460 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1114970013461 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1114970013462 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1114970013463 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1114970013464 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1114970013465 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1114970013466 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1114970013467 catalytic loop [active] 1114970013468 iron binding site [ion binding]; other site 1114970013469 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1114970013470 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1114970013471 FAD binding domain; Region: FAD_binding_4; pfam01565 1114970013472 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1114970013473 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1114970013474 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1114970013475 active site 1114970013476 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1114970013477 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1114970013478 Ligand binding site; other site 1114970013479 oligomer interface; other site 1114970013480 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1114970013481 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 1114970013482 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1114970013483 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1114970013484 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1114970013485 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1114970013486 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1114970013487 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1114970013488 Competence protein; Region: Competence; pfam03772 1114970013489 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1114970013490 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 1114970013491 inner membrane transport permease; Provisional; Region: PRK15066 1114970013492 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1114970013493 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1114970013494 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114970013495 Walker A/P-loop; other site 1114970013496 ATP binding site [chemical binding]; other site 1114970013497 Q-loop/lid; other site 1114970013498 ABC transporter signature motif; other site 1114970013499 Walker B; other site 1114970013500 D-loop; other site 1114970013501 H-loop/switch region; other site 1114970013502 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1114970013503 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1114970013504 putative C-terminal domain interface [polypeptide binding]; other site 1114970013505 putative GSH binding site (G-site) [chemical binding]; other site 1114970013506 putative dimer interface [polypeptide binding]; other site 1114970013507 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1114970013508 putative N-terminal domain interface [polypeptide binding]; other site 1114970013509 putative dimer interface [polypeptide binding]; other site 1114970013510 putative substrate binding pocket (H-site) [chemical binding]; other site 1114970013511 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1114970013512 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1114970013513 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 1114970013514 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1114970013515 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1114970013516 active site 1114970013517 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1114970013518 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970013519 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1114970013520 putative effector binding pocket; other site 1114970013521 dimerization interface [polypeptide binding]; other site 1114970013522 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 1114970013523 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 1114970013524 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1114970013525 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 1114970013526 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1114970013527 TPR repeat; Region: TPR_11; pfam13414 1114970013528 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114970013529 binding surface 1114970013530 TPR motif; other site 1114970013531 Protein of unknown function (DUF3613); Region: DUF3613; pfam12266 1114970013532 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 1114970013533 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1114970013534 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1114970013535 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1114970013536 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1114970013537 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1114970013538 ATP binding site [chemical binding]; other site 1114970013539 Walker A motif; other site 1114970013540 hexamer interface [polypeptide binding]; other site 1114970013541 Walker B motif; other site 1114970013542 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970013543 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1114970013544 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 1114970013545 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1114970013546 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 1114970013547 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 1114970013548 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 1114970013549 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1114970013550 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1114970013551 Walker A motif; other site 1114970013552 ATP binding site [chemical binding]; other site 1114970013553 Walker B motif; other site 1114970013554 arginine finger; other site 1114970013555 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 1114970013556 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1114970013557 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970013558 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1114970013559 AsnC family; Region: AsnC_trans_reg; pfam01037 1114970013560 Predicted membrane protein [Function unknown]; Region: COG2364 1114970013561 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 1114970013562 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114970013563 FeS/SAM binding site; other site 1114970013564 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1114970013565 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1114970013566 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114970013567 catalytic residue [active] 1114970013568 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1114970013569 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970013570 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970013571 homodimer interface [polypeptide binding]; other site 1114970013572 catalytic residue [active] 1114970013573 LysE type translocator; Region: LysE; cl00565 1114970013574 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1114970013575 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970013576 dimerization interface [polypeptide binding]; other site 1114970013577 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970013578 dimer interface [polypeptide binding]; other site 1114970013579 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970013580 putative CheW interface [polypeptide binding]; other site 1114970013581 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1114970013582 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970013583 DNA-binding site [nucleotide binding]; DNA binding site 1114970013584 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970013585 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970013586 homodimer interface [polypeptide binding]; other site 1114970013587 catalytic residue [active] 1114970013588 short chain dehydrogenase; Provisional; Region: PRK06172 1114970013589 classical (c) SDRs; Region: SDR_c; cd05233 1114970013590 NAD(P) binding site [chemical binding]; other site 1114970013591 active site 1114970013592 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1114970013593 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1114970013594 NAD(P) binding site [chemical binding]; other site 1114970013595 substrate binding site [chemical binding]; other site 1114970013596 dimer interface [polypeptide binding]; other site 1114970013597 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1114970013598 active site 1114970013599 dimer interface [polypeptide binding]; other site 1114970013600 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114970013601 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970013602 active site 1114970013603 phosphorylation site [posttranslational modification] 1114970013604 intermolecular recognition site; other site 1114970013605 dimerization interface [polypeptide binding]; other site 1114970013606 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970013607 DNA binding site [nucleotide binding] 1114970013608 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970013609 dimerization interface [polypeptide binding]; other site 1114970013610 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970013611 dimer interface [polypeptide binding]; other site 1114970013612 phosphorylation site [posttranslational modification] 1114970013613 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970013614 ATP binding site [chemical binding]; other site 1114970013615 Mg2+ binding site [ion binding]; other site 1114970013616 G-X-G motif; other site 1114970013617 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1114970013618 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1114970013619 pyrimidine utilization protein D; Region: RutD; TIGR03611 1114970013620 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1114970013621 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1114970013622 CoenzymeA binding site [chemical binding]; other site 1114970013623 subunit interaction site [polypeptide binding]; other site 1114970013624 PHB binding site; other site 1114970013625 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1114970013626 catalytic core [active] 1114970013627 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 1114970013628 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1114970013629 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1114970013630 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1114970013631 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1114970013632 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1114970013633 ABC transporter substrate binding protein; Region: ABC_sub_bind; cl17301 1114970013634 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114970013635 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970013636 dimerization interface [polypeptide binding]; other site 1114970013637 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970013638 dimer interface [polypeptide binding]; other site 1114970013639 phosphorylation site [posttranslational modification] 1114970013640 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970013641 ATP binding site [chemical binding]; other site 1114970013642 Mg2+ binding site [ion binding]; other site 1114970013643 G-X-G motif; other site 1114970013644 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970013645 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970013646 active site 1114970013647 phosphorylation site [posttranslational modification] 1114970013648 intermolecular recognition site; other site 1114970013649 dimerization interface [polypeptide binding]; other site 1114970013650 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1114970013651 active site 1 [active] 1114970013652 dimer interface [polypeptide binding]; other site 1114970013653 active site 2 [active] 1114970013654 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1114970013655 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1114970013656 dimer interface [polypeptide binding]; other site 1114970013657 active site 1114970013658 Domain of unknown function (DUF3859); Region: DUF3859; pfam12975 1114970013659 Amidohydrolase; Region: Amidohydro_2; pfam04909 1114970013660 Pirin; Region: Pirin; pfam02678 1114970013661 Pirin-related protein [General function prediction only]; Region: COG1741 1114970013662 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1114970013663 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1114970013664 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1114970013665 heat shock protein 90; Provisional; Region: PRK05218 1114970013666 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970013667 ATP binding site [chemical binding]; other site 1114970013668 Mg2+ binding site [ion binding]; other site 1114970013669 G-X-G motif; other site 1114970013670 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1114970013671 CoenzymeA binding site [chemical binding]; other site 1114970013672 subunit interaction site [polypeptide binding]; other site 1114970013673 PHB binding site; other site 1114970013674 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1114970013675 CoenzymeA binding site [chemical binding]; other site 1114970013676 subunit interaction site [polypeptide binding]; other site 1114970013677 PHB binding site; other site 1114970013678 Predicted membrane protein [Function unknown]; Region: COG3821 1114970013679 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1114970013680 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1114970013681 CoA binding domain; Region: CoA_binding; pfam02629 1114970013682 CoA-ligase; Region: Ligase_CoA; pfam00549 1114970013683 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1114970013684 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1114970013685 CoA-ligase; Region: Ligase_CoA; pfam00549 1114970013686 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1114970013687 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1114970013688 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114970013689 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1114970013690 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1114970013691 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1114970013692 E3 interaction surface; other site 1114970013693 lipoyl attachment site [posttranslational modification]; other site 1114970013694 e3 binding domain; Region: E3_binding; pfam02817 1114970013695 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1114970013696 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1114970013697 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1114970013698 TPP-binding site [chemical binding]; other site 1114970013699 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1114970013700 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1114970013701 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1114970013702 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05675 1114970013703 L-aspartate oxidase; Provisional; Region: PRK06175 1114970013704 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1114970013705 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 1114970013706 SdhC subunit interface [polypeptide binding]; other site 1114970013707 proximal heme binding site [chemical binding]; other site 1114970013708 cardiolipin binding site; other site 1114970013709 Iron-sulfur protein interface; other site 1114970013710 proximal quinone binding site [chemical binding]; other site 1114970013711 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1114970013712 SdhD (CybS) interface [polypeptide binding]; other site 1114970013713 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1114970013714 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1114970013715 dimer interface [polypeptide binding]; other site 1114970013716 active site 1114970013717 citrylCoA binding site [chemical binding]; other site 1114970013718 NADH binding [chemical binding]; other site 1114970013719 cationic pore residues; other site 1114970013720 oxalacetate/citrate binding site [chemical binding]; other site 1114970013721 coenzyme A binding site [chemical binding]; other site 1114970013722 catalytic triad [active] 1114970013723 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1114970013724 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1114970013725 Na binding site [ion binding]; other site 1114970013726 Predicted membrane protein [Function unknown]; Region: COG3162 1114970013727 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1114970013728 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1114970013729 VacJ like lipoprotein; Region: VacJ; cl01073 1114970013730 Protein of unknown function (DUF808); Region: DUF808; pfam05661 1114970013731 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1114970013732 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114970013733 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1114970013734 Transposase IS200 like; Region: Y1_Tnp; cl00848 1114970013735 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 1114970013736 glyoxylate carboligase; Provisional; Region: PRK11269 1114970013737 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1114970013738 PYR/PP interface [polypeptide binding]; other site 1114970013739 dimer interface [polypeptide binding]; other site 1114970013740 TPP binding site [chemical binding]; other site 1114970013741 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1114970013742 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 1114970013743 TPP-binding site [chemical binding]; other site 1114970013744 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 1114970013745 tartronate semialdehyde reductase; Provisional; Region: PRK15059 1114970013746 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1114970013747 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 1114970013748 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 1114970013749 MOFRL family; Region: MOFRL; pfam05161 1114970013750 pyruvate kinase; Provisional; Region: PRK06247 1114970013751 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1114970013752 domain interfaces; other site 1114970013753 active site 1114970013754 Urea transporter; Region: UT; pfam03253 1114970013755 Ion transport protein; Region: Ion_trans; pfam00520 1114970013756 Ion channel; Region: Ion_trans_2; pfam07885 1114970013757 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1114970013758 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1114970013759 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1114970013760 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1114970013761 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970013762 putative substrate translocation pore; other site 1114970013763 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1114970013764 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1114970013765 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1114970013766 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 1114970013767 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1114970013768 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1114970013769 acyl-activating enzyme (AAE) consensus motif; other site 1114970013770 putative AMP binding site [chemical binding]; other site 1114970013771 putative active site [active] 1114970013772 putative CoA binding site [chemical binding]; other site 1114970013773 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 1114970013774 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1114970013775 Cupin domain; Region: Cupin_2; cl17218 1114970013776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970013777 putative substrate translocation pore; other site 1114970013778 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1114970013779 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1114970013780 Tetramer interface [polypeptide binding]; other site 1114970013781 active site 1114970013782 FMN-binding site [chemical binding]; other site 1114970013783 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114970013784 HemK family putative methylases; Region: hemK_fam; TIGR00536 1114970013785 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970013786 S-adenosylmethionine binding site [chemical binding]; other site 1114970013787 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1114970013788 Isochorismatase family; Region: Isochorismatase; pfam00857 1114970013789 catalytic triad [active] 1114970013790 conserved cis-peptide bond; other site 1114970013791 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1114970013792 Smr domain; Region: Smr; pfam01713 1114970013793 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1114970013794 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1114970013795 cofactor binding site; other site 1114970013796 DNA binding site [nucleotide binding] 1114970013797 substrate interaction site [chemical binding]; other site 1114970013798 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 1114970013799 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1114970013800 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1114970013801 active site 1114970013802 DNA binding site [nucleotide binding] 1114970013803 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1114970013804 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1114970013805 Catalytic site [active] 1114970013806 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 1114970013807 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 1114970013808 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 1114970013809 Predicted chitinase [General function prediction only]; Region: COG3179 1114970013810 catalytic residue [active] 1114970013811 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1114970013812 Phage Tail Protein X; Region: Phage_tail_X; cl02088 1114970013813 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1114970013814 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 1114970013815 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1114970013816 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1114970013817 Phage tail tube protein FII; Region: Phage_tube; pfam04985 1114970013818 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 1114970013819 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 1114970013820 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 1114970013821 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 1114970013822 Baseplate J-like protein; Region: Baseplate_J; cl01294 1114970013823 Phage baseplate assembly protein W [General function prediction only]; Region: COG3628 1114970013824 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1114970013825 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 1114970013826 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 1114970013827 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 1114970013828 Clp protease; Region: CLP_protease; pfam00574 1114970013829 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1114970013830 oligomer interface [polypeptide binding]; other site 1114970013831 active site residues [active] 1114970013832 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 1114970013833 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 1114970013834 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 1114970013835 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 1114970013836 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 1114970013837 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1114970013838 active site 1114970013839 metal binding site [ion binding]; metal-binding site 1114970013840 interdomain interaction site; other site 1114970013841 Predicted P-loop ATPase and inactivated derivatives [General function prediction only]; Region: COG5545 1114970013842 Virulence-associated protein E; Region: VirE; pfam05272 1114970013843 phage/conjugal plasmid C-4 type zinc finger protein, TraR family; Region: C4_traR_proteo; TIGR02419 1114970013844 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1114970013845 Catalytic site [active] 1114970013846 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 1114970013847 Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112 1114970013848 HD domain; Region: HD_3; cl17350 1114970013849 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 1114970013850 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1114970013851 active site 1114970013852 DNA binding site [nucleotide binding] 1114970013853 Int/Topo IB signature motif; other site 1114970013854 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1114970013855 GTP cyclohydrolase I; Provisional; Region: PLN03044 1114970013856 homodecamer interface [polypeptide binding]; other site 1114970013857 active site 1114970013858 putative catalytic site residues [active] 1114970013859 zinc binding site [ion binding]; other site 1114970013860 GTP-CH-I/GFRP interaction surface; other site 1114970013861 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1114970013862 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 1114970013863 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1114970013864 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970013865 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970013866 homodimer interface [polypeptide binding]; other site 1114970013867 catalytic residue [active] 1114970013868 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114970013869 MarR family; Region: MarR_2; pfam12802 1114970013870 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1114970013871 MULE transposase domain; Region: MULE; pfam10551 1114970013872 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1114970013873 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1114970013874 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1114970013875 active site 1114970013876 homotetramer interface [polypeptide binding]; other site 1114970013877 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1114970013878 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 1114970013879 active site 1114970013880 catalytic site [active] 1114970013881 tetramer interface [polypeptide binding]; other site 1114970013882 OHCU decarboxylase; Region: UHCUDC; TIGR03164 1114970013883 allantoicase; Provisional; Region: PRK13257 1114970013884 Allantoicase repeat; Region: Allantoicase; pfam03561 1114970013885 Allantoicase repeat; Region: Allantoicase; pfam03561 1114970013886 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 1114970013887 ureidoglycolate hydrolase; Provisional; Region: PRK03606 1114970013888 Protein of unknown function (DUF989); Region: DUF989; pfam06181 1114970013889 Predicted membrane protein [Function unknown]; Region: COG3748 1114970013890 Cytochrome c; Region: Cytochrom_C; pfam00034 1114970013891 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 1114970013892 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1114970013893 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1114970013894 active site 1114970013895 nucleophile elbow; other site 1114970013896 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1114970013897 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1114970013898 putative acyl-acceptor binding pocket; other site 1114970013899 septum formation inhibitor; Reviewed; Region: minC; PRK00339 1114970013900 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1114970013901 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1114970013902 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1114970013903 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1114970013904 Switch I; other site 1114970013905 Switch II; other site 1114970013906 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1114970013907 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1114970013908 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1114970013909 active site 1114970013910 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1114970013911 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1114970013912 active site 1114970013913 metal binding site [ion binding]; metal-binding site 1114970013914 transcriptional regulator protein; Region: phnR; TIGR03337 1114970013915 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970013916 DNA-binding site [nucleotide binding]; DNA binding site 1114970013917 UTRA domain; Region: UTRA; pfam07702 1114970013918 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1114970013919 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1114970013920 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 1114970013921 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1114970013922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970013923 dimer interface [polypeptide binding]; other site 1114970013924 conserved gate region; other site 1114970013925 putative PBP binding loops; other site 1114970013926 ABC-ATPase subunit interface; other site 1114970013927 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1114970013928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970013929 dimer interface [polypeptide binding]; other site 1114970013930 conserved gate region; other site 1114970013931 ABC-ATPase subunit interface; other site 1114970013932 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1114970013933 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114970013934 Walker A/P-loop; other site 1114970013935 ATP binding site [chemical binding]; other site 1114970013936 Q-loop/lid; other site 1114970013937 ABC transporter signature motif; other site 1114970013938 Walker B; other site 1114970013939 D-loop; other site 1114970013940 H-loop/switch region; other site 1114970013941 TOBE domain; Region: TOBE_2; pfam08402 1114970013942 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1114970013943 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1114970013944 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 1114970013945 Protein of unknown function (DUF1326); Region: DUF1326; cl02375 1114970013946 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1114970013947 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1114970013948 NAD(P) binding site [chemical binding]; other site 1114970013949 carboxy-terminal protease; Provisional; Region: PRK11186 1114970013950 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1114970013951 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1114970013952 protein binding site [polypeptide binding]; other site 1114970013953 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1114970013954 Catalytic dyad [active] 1114970013955 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 1114970013956 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970013957 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 1114970013958 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114970013959 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970013960 metal binding site [ion binding]; metal-binding site 1114970013961 active site 1114970013962 I-site; other site 1114970013963 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1114970013964 RHS Repeat; Region: RHS_repeat; pfam05593 1114970013965 RHS Repeat; Region: RHS_repeat; pfam05593 1114970013966 RHS Repeat; Region: RHS_repeat; cl11982 1114970013967 RHS Repeat; Region: RHS_repeat; pfam05593 1114970013968 RHS Repeat; Region: RHS_repeat; pfam05593 1114970013969 RHS Repeat; Region: RHS_repeat; pfam05593 1114970013970 RHS Repeat; Region: RHS_repeat; cl11982 1114970013971 RHS Repeat; Region: RHS_repeat; pfam05593 1114970013972 RHS Repeat; Region: RHS_repeat; pfam05593 1114970013973 RHS protein; Region: RHS; pfam03527 1114970013974 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1114970013975 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114970013976 non-specific DNA binding site [nucleotide binding]; other site 1114970013977 salt bridge; other site 1114970013978 sequence-specific DNA binding site [nucleotide binding]; other site 1114970013979 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 1114970013980 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1114970013981 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1114970013982 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1114970013983 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 1114970013984 putative heme binding pocket [chemical binding]; other site 1114970013985 recombination associated protein; Reviewed; Region: rdgC; PRK00321 1114970013986 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1114970013987 Sodium Bile acid symporter family; Region: SBF; pfam01758 1114970013988 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1114970013989 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 1114970013990 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1114970013991 putative acyl-acceptor binding pocket; other site 1114970013992 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318 1114970013993 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1114970013994 gating phenylalanine in ion channel; other site 1114970013995 Cupin domain; Region: Cupin_2; cl17218 1114970013996 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970013997 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970013998 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970013999 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114970014000 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 1114970014001 Na binding site [ion binding]; other site 1114970014002 PAS fold; Region: PAS_7; pfam12860 1114970014003 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114970014004 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970014005 dimer interface [polypeptide binding]; other site 1114970014006 phosphorylation site [posttranslational modification] 1114970014007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970014008 ATP binding site [chemical binding]; other site 1114970014009 Mg2+ binding site [ion binding]; other site 1114970014010 G-X-G motif; other site 1114970014011 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1114970014012 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970014013 active site 1114970014014 phosphorylation site [posttranslational modification] 1114970014015 intermolecular recognition site; other site 1114970014016 dimerization interface [polypeptide binding]; other site 1114970014017 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 1114970014018 RmuC family; Region: RmuC; pfam02646 1114970014019 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 1114970014020 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1114970014021 catalytic residues [active] 1114970014022 dimer interface [polypeptide binding]; other site 1114970014023 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1114970014024 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970014025 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114970014026 MarR family; Region: MarR; pfam01047 1114970014027 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970014028 DNA binding residues [nucleotide binding] 1114970014029 dimerization interface [polypeptide binding]; other site 1114970014030 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1114970014031 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1114970014032 RHS Repeat; Region: RHS_repeat; pfam05593 1114970014033 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1114970014034 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 1114970014035 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 1114970014036 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1114970014037 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1114970014038 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1114970014039 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1114970014040 catalytic core [active] 1114970014041 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1114970014042 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1114970014043 putative dimer interface [polypeptide binding]; other site 1114970014044 active site pocket [active] 1114970014045 putative cataytic base [active] 1114970014046 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1114970014047 homotrimer interface [polypeptide binding]; other site 1114970014048 Walker A motif; other site 1114970014049 GTP binding site [chemical binding]; other site 1114970014050 Walker B motif; other site 1114970014051 cobyric acid synthase; Provisional; Region: PRK00784 1114970014052 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1114970014053 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1114970014054 catalytic triad [active] 1114970014055 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 1114970014056 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970014057 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970014058 homodimer interface [polypeptide binding]; other site 1114970014059 catalytic residue [active] 1114970014060 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1114970014061 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1114970014062 FMN binding site [chemical binding]; other site 1114970014063 dimer interface [polypeptide binding]; other site 1114970014064 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1114970014065 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1114970014066 catalytic triad [active] 1114970014067 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 1114970014068 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1114970014069 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1114970014070 Walker A motif; other site 1114970014071 homodimer interface [polypeptide binding]; other site 1114970014072 ATP binding site [chemical binding]; other site 1114970014073 hydroxycobalamin binding site [chemical binding]; other site 1114970014074 Walker B motif; other site 1114970014075 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1114970014076 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1114970014077 NlpC/P60 family; Region: NLPC_P60; pfam00877 1114970014078 NlpC/P60 family; Region: NLPC_P60; pfam00877 1114970014079 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1114970014080 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970014081 Walker A motif; other site 1114970014082 ATP binding site [chemical binding]; other site 1114970014083 Walker B motif; other site 1114970014084 arginine finger; other site 1114970014085 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1114970014086 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1114970014087 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 1114970014088 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1114970014089 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1114970014090 dimerization interface [polypeptide binding]; other site 1114970014091 putative ATP binding site [chemical binding]; other site 1114970014092 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1114970014093 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1114970014094 active site 1114970014095 substrate binding site [chemical binding]; other site 1114970014096 cosubstrate binding site; other site 1114970014097 catalytic site [active] 1114970014098 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 1114970014099 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831 1114970014100 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1114970014101 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1114970014102 homodimer interface [polypeptide binding]; other site 1114970014103 metal binding site [ion binding]; metal-binding site 1114970014104 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1114970014105 homodimer interface [polypeptide binding]; other site 1114970014106 active site 1114970014107 putative chemical substrate binding site [chemical binding]; other site 1114970014108 metal binding site [ion binding]; metal-binding site 1114970014109 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1114970014110 HD domain; Region: HD_4; pfam13328 1114970014111 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1114970014112 synthetase active site [active] 1114970014113 NTP binding site [chemical binding]; other site 1114970014114 metal binding site [ion binding]; metal-binding site 1114970014115 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1114970014116 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1114970014117 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1114970014118 TRAM domain; Region: TRAM; pfam01938 1114970014119 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970014120 S-adenosylmethionine binding site [chemical binding]; other site 1114970014121 cysteine synthase B; Region: cysM; TIGR01138 1114970014122 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1114970014123 dimer interface [polypeptide binding]; other site 1114970014124 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970014125 catalytic residue [active] 1114970014126 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 1114970014127 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970014128 dimerization interface [polypeptide binding]; other site 1114970014129 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970014130 dimer interface [polypeptide binding]; other site 1114970014131 phosphorylation site [posttranslational modification] 1114970014132 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970014133 ATP binding site [chemical binding]; other site 1114970014134 Mg2+ binding site [ion binding]; other site 1114970014135 G-X-G motif; other site 1114970014136 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970014137 active site 1114970014138 phosphorylation site [posttranslational modification] 1114970014139 intermolecular recognition site; other site 1114970014140 dimerization interface [polypeptide binding]; other site 1114970014141 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1114970014142 putative binding surface; other site 1114970014143 active site 1114970014144 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1114970014145 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 1114970014146 putative ligand binding site [chemical binding]; other site 1114970014147 putative NAD binding site [chemical binding]; other site 1114970014148 catalytic site [active] 1114970014149 Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187 1114970014150 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1114970014151 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1114970014152 catalytic residues [active] 1114970014153 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1114970014154 ArsC family; Region: ArsC; pfam03960 1114970014155 catalytic residues [active] 1114970014156 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1114970014157 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1114970014158 Predicted membrane protein [Function unknown]; Region: COG3308 1114970014159 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 1114970014160 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1114970014161 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1114970014162 Ligand Binding Site [chemical binding]; other site 1114970014163 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 1114970014164 hypothetical protein; Provisional; Region: PRK04860 1114970014165 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1114970014166 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1114970014167 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1114970014168 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1114970014169 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1114970014170 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1114970014171 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114970014172 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970014173 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1114970014174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970014175 ATP binding site [chemical binding]; other site 1114970014176 Mg2+ binding site [ion binding]; other site 1114970014177 G-X-G motif; other site 1114970014178 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 1114970014179 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970014180 active site 1114970014181 phosphorylation site [posttranslational modification] 1114970014182 intermolecular recognition site; other site 1114970014183 dimerization interface [polypeptide binding]; other site 1114970014184 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970014185 DNA binding site [nucleotide binding] 1114970014186 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1114970014187 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1114970014188 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1114970014189 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1114970014190 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1114970014191 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1114970014192 sensor protein RstB; Provisional; Region: PRK10604 1114970014193 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970014194 dimerization interface [polypeptide binding]; other site 1114970014195 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970014196 dimer interface [polypeptide binding]; other site 1114970014197 phosphorylation site [posttranslational modification] 1114970014198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970014199 ATP binding site [chemical binding]; other site 1114970014200 Mg2+ binding site [ion binding]; other site 1114970014201 G-X-G motif; other site 1114970014202 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114970014203 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970014204 active site 1114970014205 phosphorylation site [posttranslational modification] 1114970014206 intermolecular recognition site; other site 1114970014207 dimerization interface [polypeptide binding]; other site 1114970014208 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970014209 DNA binding site [nucleotide binding] 1114970014210 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 1114970014211 ATP cone domain; Region: ATP-cone; pfam03477 1114970014212 ATP cone domain; Region: ATP-cone; pfam03477 1114970014213 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1114970014214 active site 1114970014215 dimer interface [polypeptide binding]; other site 1114970014216 catalytic residues [active] 1114970014217 effector binding site; other site 1114970014218 R2 peptide binding site; other site 1114970014219 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1114970014220 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1114970014221 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1114970014222 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1114970014223 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 1114970014224 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1114970014225 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1114970014226 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1114970014227 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1114970014228 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1114970014229 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1114970014230 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1114970014231 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1114970014232 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1114970014233 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970014234 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1114970014235 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970014236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970014237 active site 1114970014238 phosphorylation site [posttranslational modification] 1114970014239 intermolecular recognition site; other site 1114970014240 dimerization interface [polypeptide binding]; other site 1114970014241 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 1114970014242 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1114970014243 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1114970014244 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 1114970014245 FlgN protein; Region: FlgN; pfam05130 1114970014246 Flagellar regulator YcgR; Region: YcgR; pfam07317 1114970014247 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1114970014248 PilZ domain; Region: PilZ; pfam07238 1114970014249 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970014250 putative substrate translocation pore; other site 1114970014251 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970014252 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1114970014253 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1114970014254 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114970014255 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970014256 ATP binding site [chemical binding]; other site 1114970014257 Mg2+ binding site [ion binding]; other site 1114970014258 G-X-G motif; other site 1114970014259 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1114970014260 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970014261 active site 1114970014262 phosphorylation site [posttranslational modification] 1114970014263 intermolecular recognition site; other site 1114970014264 dimerization interface [polypeptide binding]; other site 1114970014265 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114970014266 binding surface 1114970014267 TPR motif; other site 1114970014268 TPR repeat; Region: TPR_11; pfam13414 1114970014269 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1114970014270 Domain of unknown function (DUF1910); Region: DUF1910; pfam08928 1114970014271 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 1114970014272 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 1114970014273 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1114970014274 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1114970014275 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1114970014276 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1114970014277 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1114970014278 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1114970014279 RTX toxin acyltransferase family; Region: HlyC; cl01131 1114970014280 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1114970014281 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1114970014282 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1114970014283 Arc-like DNA binding domain; Region: Arc; pfam03869 1114970014284 Helix-turn-helix domain; Region: HTH_18; pfam12833 1114970014285 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1114970014286 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1114970014287 MgtE intracellular N domain; Region: MgtE_N; smart00924 1114970014288 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1114970014289 Divalent cation transporter; Region: MgtE; cl00786 1114970014290 carbon storage regulator; Provisional; Region: PRK01712 1114970014291 aspartate kinase; Reviewed; Region: PRK06635 1114970014292 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1114970014293 putative nucleotide binding site [chemical binding]; other site 1114970014294 putative catalytic residues [active] 1114970014295 putative Mg ion binding site [ion binding]; other site 1114970014296 putative aspartate binding site [chemical binding]; other site 1114970014297 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1114970014298 putative allosteric regulatory site; other site 1114970014299 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1114970014300 putative allosteric regulatory residue; other site 1114970014301 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1114970014302 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1114970014303 motif 1; other site 1114970014304 active site 1114970014305 motif 2; other site 1114970014306 motif 3; other site 1114970014307 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1114970014308 DHHA1 domain; Region: DHHA1; pfam02272 1114970014309 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1114970014310 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1114970014311 tetramer interface [polypeptide binding]; other site 1114970014312 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970014313 catalytic residue [active] 1114970014314 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-II; Region: Lumazine_synthase-II; cd09208 1114970014315 active site 1114970014316 homopentamer interface [polypeptide binding]; other site 1114970014317 dimer interface [polypeptide binding]; other site 1114970014318 succinylglutamate desuccinylase; Provisional; Region: PRK05324 1114970014319 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1114970014320 active site 1114970014321 Zn binding site [ion binding]; other site 1114970014322 succinylarginine dihydrolase; Provisional; Region: PRK13281 1114970014323 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 1114970014324 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 1114970014325 NAD(P) binding site [chemical binding]; other site 1114970014326 catalytic residues [active] 1114970014327 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1114970014328 arginine N-succinyltransferase; Region: arg_catab_AstA; TIGR03244 1114970014329 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1114970014330 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 1114970014331 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 1114970014332 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114970014333 inhibitor-cofactor binding pocket; inhibition site 1114970014334 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970014335 catalytic residue [active] 1114970014336 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1114970014337 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1114970014338 conserved cys residue [active] 1114970014339 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970014340 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970014341 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1114970014342 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1114970014343 Walker A/P-loop; other site 1114970014344 ATP binding site [chemical binding]; other site 1114970014345 Q-loop/lid; other site 1114970014346 ABC transporter signature motif; other site 1114970014347 Walker B; other site 1114970014348 D-loop; other site 1114970014349 H-loop/switch region; other site 1114970014350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970014351 dimer interface [polypeptide binding]; other site 1114970014352 conserved gate region; other site 1114970014353 putative PBP binding loops; other site 1114970014354 ABC-ATPase subunit interface; other site 1114970014355 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114970014356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970014357 dimer interface [polypeptide binding]; other site 1114970014358 conserved gate region; other site 1114970014359 putative PBP binding loops; other site 1114970014360 ABC-ATPase subunit interface; other site 1114970014361 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1114970014362 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970014363 substrate binding pocket [chemical binding]; other site 1114970014364 membrane-bound complex binding site; other site 1114970014365 hinge residues; other site 1114970014366 acetyl-CoA synthetase; Provisional; Region: PRK00174 1114970014367 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1114970014368 active site 1114970014369 CoA binding site [chemical binding]; other site 1114970014370 acyl-activating enzyme (AAE) consensus motif; other site 1114970014371 AMP binding site [chemical binding]; other site 1114970014372 acetate binding site [chemical binding]; other site 1114970014373 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1114970014374 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1114970014375 dimer interface [polypeptide binding]; other site 1114970014376 putative radical transfer pathway; other site 1114970014377 diiron center [ion binding]; other site 1114970014378 tyrosyl radical; other site 1114970014379 BRO family, N-terminal domain; Region: Bro-N; smart01040 1114970014380 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114970014381 non-specific DNA binding site [nucleotide binding]; other site 1114970014382 salt bridge; other site 1114970014383 sequence-specific DNA binding site [nucleotide binding]; other site 1114970014384 HipA N-terminal domain; Region: Couple_hipA; cl11853 1114970014385 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1114970014386 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1114970014387 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1114970014388 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1114970014389 Helix-turn-helix domain; Region: HTH_18; pfam12833 1114970014390 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970014391 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114970014392 salt bridge; other site 1114970014393 non-specific DNA binding site [nucleotide binding]; other site 1114970014394 sequence-specific DNA binding site [nucleotide binding]; other site 1114970014395 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1114970014396 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1114970014397 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970014398 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114970014399 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1114970014400 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 1114970014401 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970014402 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970014403 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970014404 dimerization interface [polypeptide binding]; other site 1114970014405 hypothetical protein; Validated; Region: PRK06186 1114970014406 conserved cys residue [active] 1114970014407 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1114970014408 Protein of unknown function (DUF2025); Region: DUF2025; pfam09634 1114970014409 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1114970014410 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1114970014411 active site 1114970014412 catalytic site [active] 1114970014413 metal binding site [ion binding]; metal-binding site 1114970014414 Predicted membrane protein [Function unknown]; Region: COG3212 1114970014415 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1114970014416 HAMP domain; Region: HAMP; pfam00672 1114970014417 dimerization interface [polypeptide binding]; other site 1114970014418 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970014419 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970014420 dimer interface [polypeptide binding]; other site 1114970014421 putative CheW interface [polypeptide binding]; other site 1114970014422 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1114970014423 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 1114970014424 Cl binding site [ion binding]; other site 1114970014425 oligomer interface [polypeptide binding]; other site 1114970014426 major facilitator superfamily transporter; Provisional; Region: PRK05122 1114970014427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970014428 putative substrate translocation pore; other site 1114970014429 hypothetical protein; Provisional; Region: PRK09256 1114970014430 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1114970014431 aromatic amino acid transporter; Provisional; Region: PRK10238 1114970014432 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1114970014433 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1114970014434 RNA binding surface [nucleotide binding]; other site 1114970014435 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1114970014436 probable active site [active] 1114970014437 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1114970014438 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1114970014439 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1114970014440 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1114970014441 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1114970014442 active site 1114970014443 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1114970014444 intracellular septation protein A; Reviewed; Region: PRK00259 1114970014445 YciI-like protein; Reviewed; Region: PRK11370 1114970014446 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1114970014447 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114970014448 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970014449 active site 1114970014450 phosphorylation site [posttranslational modification] 1114970014451 intermolecular recognition site; other site 1114970014452 dimerization interface [polypeptide binding]; other site 1114970014453 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970014454 DNA binding site [nucleotide binding] 1114970014455 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 1114970014456 dimer interface [polypeptide binding]; other site 1114970014457 two-component sensor protein; Provisional; Region: cpxA; PRK09470 1114970014458 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970014459 ATP binding site [chemical binding]; other site 1114970014460 Mg2+ binding site [ion binding]; other site 1114970014461 G-X-G motif; other site 1114970014462 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 1114970014463 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 1114970014464 Imelysin; Region: Peptidase_M75; cl09159 1114970014465 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3490 1114970014466 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1114970014467 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1114970014468 HlyD family secretion protein; Region: HlyD_3; pfam13437 1114970014469 multidrug efflux protein; Reviewed; Region: PRK09579 1114970014470 Protein export membrane protein; Region: SecD_SecF; cl14618 1114970014471 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 1114970014472 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970014473 S-adenosylmethionine binding site [chemical binding]; other site 1114970014474 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114970014475 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970014476 dimer interface [polypeptide binding]; other site 1114970014477 phosphorylation site [posttranslational modification] 1114970014478 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970014479 ATP binding site [chemical binding]; other site 1114970014480 Mg2+ binding site [ion binding]; other site 1114970014481 G-X-G motif; other site 1114970014482 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114970014483 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970014484 active site 1114970014485 phosphorylation site [posttranslational modification] 1114970014486 intermolecular recognition site; other site 1114970014487 dimerization interface [polypeptide binding]; other site 1114970014488 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970014489 DNA binding site [nucleotide binding] 1114970014490 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 1114970014491 active site 1114970014492 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1114970014493 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1114970014494 ring oligomerisation interface [polypeptide binding]; other site 1114970014495 ATP/Mg binding site [chemical binding]; other site 1114970014496 stacking interactions; other site 1114970014497 hinge regions; other site 1114970014498 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1114970014499 oligomerisation interface [polypeptide binding]; other site 1114970014500 mobile loop; other site 1114970014501 roof hairpin; other site 1114970014502 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1114970014503 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 1114970014504 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 1114970014505 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 1114970014506 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1114970014507 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970014508 NAD(P) binding site [chemical binding]; other site 1114970014509 active site 1114970014510 antiporter inner membrane protein; Provisional; Region: PRK11670 1114970014511 Domain of unknown function DUF59; Region: DUF59; pfam01883 1114970014512 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1114970014513 Walker A motif; other site 1114970014514 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1114970014515 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1114970014516 active site 1114970014517 HIGH motif; other site 1114970014518 KMSKS motif; other site 1114970014519 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1114970014520 tRNA binding surface [nucleotide binding]; other site 1114970014521 anticodon binding site; other site 1114970014522 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1114970014523 dimer interface [polypeptide binding]; other site 1114970014524 putative tRNA-binding site [nucleotide binding]; other site 1114970014525 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 1114970014526 ferredoxin; Provisional; Region: PRK08764 1114970014527 Putative Fe-S cluster; Region: FeS; pfam04060 1114970014528 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1114970014529 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 1114970014530 electron transport complex, RnfABCDGE type, G subunit; Region: rnfG; TIGR01947 1114970014531 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 1114970014532 endonuclease III; Provisional; Region: PRK10702 1114970014533 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1114970014534 minor groove reading motif; other site 1114970014535 helix-hairpin-helix signature motif; other site 1114970014536 substrate binding pocket [chemical binding]; other site 1114970014537 active site 1114970014538 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1114970014539 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114970014540 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970014541 active site 1114970014542 phosphorylation site [posttranslational modification] 1114970014543 intermolecular recognition site; other site 1114970014544 dimerization interface [polypeptide binding]; other site 1114970014545 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970014546 DNA binding residues [nucleotide binding] 1114970014547 dimerization interface [polypeptide binding]; other site 1114970014548 argininosuccinate synthase; Provisional; Region: PRK13820 1114970014549 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1114970014550 ANP binding site [chemical binding]; other site 1114970014551 Substrate Binding Site II [chemical binding]; other site 1114970014552 Substrate Binding Site I [chemical binding]; other site 1114970014553 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1114970014554 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1114970014555 ligand binding site [chemical binding]; other site 1114970014556 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1114970014557 active site 1114970014558 substrate binding pocket [chemical binding]; other site 1114970014559 dimer interface [polypeptide binding]; other site 1114970014560 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1114970014561 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 1114970014562 dimer interface [polypeptide binding]; other site 1114970014563 catalytic site [active] 1114970014564 putative active site [active] 1114970014565 putative substrate binding site [chemical binding]; other site 1114970014566 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1114970014567 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1114970014568 dimer interface [polypeptide binding]; other site 1114970014569 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1114970014570 catalytic triad [active] 1114970014571 peroxidatic and resolving cysteines [active] 1114970014572 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 1114970014573 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1114970014574 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1114970014575 heme binding site [chemical binding]; other site 1114970014576 ferroxidase pore; other site 1114970014577 ferroxidase diiron center [ion binding]; other site 1114970014578 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1114970014579 putative GSH binding site [chemical binding]; other site 1114970014580 catalytic residues [active] 1114970014581 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1114970014582 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 1114970014583 putative [Fe4-S4] binding site [ion binding]; other site 1114970014584 putative molybdopterin cofactor binding site [chemical binding]; other site 1114970014585 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1114970014586 putative molybdopterin cofactor binding site; other site 1114970014587 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1114970014588 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1114970014589 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1114970014590 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1114970014591 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1114970014592 Walker A/P-loop; other site 1114970014593 ATP binding site [chemical binding]; other site 1114970014594 Q-loop/lid; other site 1114970014595 ABC transporter signature motif; other site 1114970014596 Walker B; other site 1114970014597 D-loop; other site 1114970014598 H-loop/switch region; other site 1114970014599 TOBE domain; Region: TOBE_2; pfam08402 1114970014600 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1114970014601 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1114970014602 putative deacylase active site [active] 1114970014603 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1114970014604 amphipathic channel; other site 1114970014605 Asn-Pro-Ala signature motifs; other site 1114970014606 glycerol kinase; Provisional; Region: glpK; PRK00047 1114970014607 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1114970014608 N- and C-terminal domain interface [polypeptide binding]; other site 1114970014609 active site 1114970014610 MgATP binding site [chemical binding]; other site 1114970014611 catalytic site [active] 1114970014612 metal binding site [ion binding]; metal-binding site 1114970014613 glycerol binding site [chemical binding]; other site 1114970014614 homotetramer interface [polypeptide binding]; other site 1114970014615 homodimer interface [polypeptide binding]; other site 1114970014616 protein IIAGlc interface [polypeptide binding]; other site 1114970014617 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 1114970014618 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1114970014619 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1114970014620 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1114970014621 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 1114970014622 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970014623 substrate binding pocket [chemical binding]; other site 1114970014624 membrane-bound complex binding site; other site 1114970014625 hinge residues; other site 1114970014626 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114970014627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970014628 dimer interface [polypeptide binding]; other site 1114970014629 conserved gate region; other site 1114970014630 putative PBP binding loops; other site 1114970014631 ABC-ATPase subunit interface; other site 1114970014632 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114970014633 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970014634 dimer interface [polypeptide binding]; other site 1114970014635 conserved gate region; other site 1114970014636 putative PBP binding loops; other site 1114970014637 ABC-ATPase subunit interface; other site 1114970014638 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1114970014639 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1114970014640 Walker A/P-loop; other site 1114970014641 ATP binding site [chemical binding]; other site 1114970014642 Q-loop/lid; other site 1114970014643 ABC transporter signature motif; other site 1114970014644 Walker B; other site 1114970014645 D-loop; other site 1114970014646 H-loop/switch region; other site 1114970014647 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1114970014648 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970014649 dimer interface [polypeptide binding]; other site 1114970014650 phosphorylation site [posttranslational modification] 1114970014651 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970014652 Mg2+ binding site [ion binding]; other site 1114970014653 G-X-G motif; other site 1114970014654 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1114970014655 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970014656 active site 1114970014657 phosphorylation site [posttranslational modification] 1114970014658 intermolecular recognition site; other site 1114970014659 dimerization interface [polypeptide binding]; other site 1114970014660 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970014661 Walker A motif; other site 1114970014662 ATP binding site [chemical binding]; other site 1114970014663 Walker B motif; other site 1114970014664 arginine finger; other site 1114970014665 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1114970014666 GlpM protein; Region: GlpM; pfam06942 1114970014667 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1114970014668 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1114970014669 NAD binding site [chemical binding]; other site 1114970014670 putative active site [active] 1114970014671 substrate binding site [chemical binding]; other site 1114970014672 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1114970014673 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970014674 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970014675 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1114970014676 putative effector binding pocket; other site 1114970014677 dimerization interface [polypeptide binding]; other site 1114970014678 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 1114970014679 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 1114970014680 putative aromatic amino acid binding site; other site 1114970014681 PAS domain; Region: PAS; smart00091 1114970014682 putative active site [active] 1114970014683 heme pocket [chemical binding]; other site 1114970014684 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970014685 Walker A motif; other site 1114970014686 ATP binding site [chemical binding]; other site 1114970014687 Walker B motif; other site 1114970014688 arginine finger; other site 1114970014689 glycine cleavage system protein H; Provisional; Region: PRK13380 1114970014690 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1114970014691 lipoyl attachment site [posttranslational modification]; other site 1114970014692 glycine dehydrogenase; Provisional; Region: PRK05367 1114970014693 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1114970014694 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970014695 tetramer interface [polypeptide binding]; other site 1114970014696 catalytic residue [active] 1114970014697 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1114970014698 tetramer interface [polypeptide binding]; other site 1114970014699 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970014700 catalytic residue [active] 1114970014701 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1114970014702 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1114970014703 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1114970014704 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 1114970014705 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1114970014706 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1114970014707 DNA-binding site [nucleotide binding]; DNA binding site 1114970014708 RNA-binding motif; other site 1114970014709 RDD family; Region: RDD; pfam06271 1114970014710 quinolinate synthetase; Provisional; Region: PRK09375 1114970014711 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 1114970014712 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1114970014713 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1114970014714 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1114970014715 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 1114970014716 CopC domain; Region: CopC; pfam04234 1114970014717 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1114970014718 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1114970014719 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970014720 putative substrate translocation pore; other site 1114970014721 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1114970014722 Ligand Binding Site [chemical binding]; other site 1114970014723 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 1114970014724 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114970014725 FeS/SAM binding site; other site 1114970014726 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1114970014727 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1114970014728 binding surface 1114970014729 TPR motif; other site 1114970014730 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1114970014731 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1114970014732 ligand binding site [chemical binding]; other site 1114970014733 translocation protein TolB; Provisional; Region: tolB; PRK00178 1114970014734 TolB amino-terminal domain; Region: TolB_N; pfam04052 1114970014735 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1114970014736 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1114970014737 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1114970014738 TolA protein; Region: tolA_full; TIGR02794 1114970014739 TolA protein; Region: tolA_full; TIGR02794 1114970014740 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 1114970014741 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1114970014742 TolR protein; Region: tolR; TIGR02801 1114970014743 TolQ protein; Region: tolQ; TIGR02796 1114970014744 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1114970014745 active site 1114970014746 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1114970014747 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970014748 Walker A motif; other site 1114970014749 ATP binding site [chemical binding]; other site 1114970014750 Walker B motif; other site 1114970014751 arginine finger; other site 1114970014752 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1114970014753 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1114970014754 RuvA N terminal domain; Region: RuvA_N; pfam01330 1114970014755 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1114970014756 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1114970014757 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1114970014758 active site 1114970014759 putative DNA-binding cleft [nucleotide binding]; other site 1114970014760 dimer interface [polypeptide binding]; other site 1114970014761 hypothetical protein; Validated; Region: PRK00110 1114970014762 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1114970014763 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1114970014764 dimer interface [polypeptide binding]; other site 1114970014765 anticodon binding site; other site 1114970014766 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1114970014767 homodimer interface [polypeptide binding]; other site 1114970014768 motif 1; other site 1114970014769 active site 1114970014770 motif 2; other site 1114970014771 GAD domain; Region: GAD; pfam02938 1114970014772 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1114970014773 active site 1114970014774 motif 3; other site 1114970014775 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 1114970014776 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 1114970014777 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1114970014778 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1114970014779 dimerization interface [polypeptide binding]; other site 1114970014780 DPS ferroxidase diiron center [ion binding]; other site 1114970014781 ion pore; other site 1114970014782 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1114970014783 DNA-binding site [nucleotide binding]; DNA binding site 1114970014784 RNA-binding motif; other site 1114970014785 hypothetical protein; Provisional; Region: PRK00295 1114970014786 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1114970014787 outer membrane porin, OprD family; Region: OprD; pfam03573 1114970014788 mechanosensitive channel MscS; Provisional; Region: PRK10334 1114970014789 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1114970014790 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1114970014791 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1114970014792 2-dehydropantoate 2-reductase; Provisional; Region: PRK05708 1114970014793 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1114970014794 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1114970014795 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970014796 dimerization interface [polypeptide binding]; other site 1114970014797 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1114970014798 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970014799 putative active site [active] 1114970014800 heme pocket [chemical binding]; other site 1114970014801 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970014802 dimer interface [polypeptide binding]; other site 1114970014803 phosphorylation site [posttranslational modification] 1114970014804 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970014805 ATP binding site [chemical binding]; other site 1114970014806 Mg2+ binding site [ion binding]; other site 1114970014807 G-X-G motif; other site 1114970014808 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1114970014809 hypothetical protein; Provisional; Region: PRK08999 1114970014810 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1114970014811 active site 1114970014812 8-oxo-dGMP binding site [chemical binding]; other site 1114970014813 nudix motif; other site 1114970014814 metal binding site [ion binding]; metal-binding site 1114970014815 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1114970014816 thiamine phosphate binding site [chemical binding]; other site 1114970014817 active site 1114970014818 pyrophosphate binding site [ion binding]; other site 1114970014819 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 1114970014820 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1114970014821 putative C-terminal domain interface [polypeptide binding]; other site 1114970014822 putative GSH binding site (G-site) [chemical binding]; other site 1114970014823 putative dimer interface [polypeptide binding]; other site 1114970014824 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 1114970014825 putative substrate binding pocket (H-site) [chemical binding]; other site 1114970014826 putative N-terminal domain interface [polypeptide binding]; other site 1114970014827 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1114970014828 heterotetramer interface [polypeptide binding]; other site 1114970014829 active site pocket [active] 1114970014830 cleavage site 1114970014831 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK13103 1114970014832 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1114970014833 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1114970014834 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1114970014835 nucleotide binding region [chemical binding]; other site 1114970014836 ATP-binding site [chemical binding]; other site 1114970014837 SEC-C motif; Region: SEC-C; pfam02810 1114970014838 Protein of unknown function (DUF721); Region: DUF721; pfam05258 1114970014839 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1114970014840 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114970014841 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1114970014842 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 1114970014843 Predicted deacetylase [General function prediction only]; Region: COG3233 1114970014844 putative active site [active] 1114970014845 putative Zn binding site [ion binding]; other site 1114970014846 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1114970014847 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1114970014848 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1114970014849 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1114970014850 putative active site [active] 1114970014851 putative substrate binding site [chemical binding]; other site 1114970014852 putative cosubstrate binding site; other site 1114970014853 catalytic site [active] 1114970014854 exonuclease I; Provisional; Region: sbcB; PRK11779 1114970014855 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1114970014856 active site 1114970014857 catalytic site [active] 1114970014858 substrate binding site [chemical binding]; other site 1114970014859 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1114970014860 RDD family; Region: RDD; pfam06271 1114970014861 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 1114970014862 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 1114970014863 MoxR-like ATPases [General function prediction only]; Region: COG0714 1114970014864 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970014865 Walker A motif; other site 1114970014866 ATP binding site [chemical binding]; other site 1114970014867 Walker B motif; other site 1114970014868 arginine finger; other site 1114970014869 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1114970014870 Protein of unknown function DUF58; Region: DUF58; pfam01882 1114970014871 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1114970014872 PilZ domain; Region: PilZ; pfam07238 1114970014873 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1114970014874 pyruvate kinase; Provisional; Region: PRK05826 1114970014875 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1114970014876 domain interfaces; other site 1114970014877 active site 1114970014878 hypothetical protein; Provisional; Region: PRK05713 1114970014879 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1114970014880 catalytic loop [active] 1114970014881 iron binding site [ion binding]; other site 1114970014882 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194 1114970014883 FAD binding pocket [chemical binding]; other site 1114970014884 FAD binding motif [chemical binding]; other site 1114970014885 phosphate binding motif [ion binding]; other site 1114970014886 beta-alpha-beta structure motif; other site 1114970014887 NAD binding pocket [chemical binding]; other site 1114970014888 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114970014889 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970014890 metal binding site [ion binding]; metal-binding site 1114970014891 active site 1114970014892 I-site; other site 1114970014893 putative fumarate hydratase; Provisional; Region: PRK15392 1114970014894 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 1114970014895 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1114970014896 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970014897 dimer interface [polypeptide binding]; other site 1114970014898 phosphorylation site [posttranslational modification] 1114970014899 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970014900 ATP binding site [chemical binding]; other site 1114970014901 Mg2+ binding site [ion binding]; other site 1114970014902 G-X-G motif; other site 1114970014903 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1114970014904 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970014905 active site 1114970014906 phosphorylation site [posttranslational modification] 1114970014907 intermolecular recognition site; other site 1114970014908 dimerization interface [polypeptide binding]; other site 1114970014909 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970014910 Walker A motif; other site 1114970014911 ATP binding site [chemical binding]; other site 1114970014912 Walker B motif; other site 1114970014913 arginine finger; other site 1114970014914 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1114970014915 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1114970014916 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970014917 putative substrate translocation pore; other site 1114970014918 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1114970014919 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1114970014920 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1114970014921 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1114970014922 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970014923 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1114970014924 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114970014925 Walker A/P-loop; other site 1114970014926 ATP binding site [chemical binding]; other site 1114970014927 Q-loop/lid; other site 1114970014928 ABC transporter signature motif; other site 1114970014929 Walker B; other site 1114970014930 D-loop; other site 1114970014931 H-loop/switch region; other site 1114970014932 TOBE domain; Region: TOBE_2; pfam08402 1114970014933 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1114970014934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970014935 dimer interface [polypeptide binding]; other site 1114970014936 conserved gate region; other site 1114970014937 putative PBP binding loops; other site 1114970014938 ABC-ATPase subunit interface; other site 1114970014939 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1114970014940 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970014941 dimer interface [polypeptide binding]; other site 1114970014942 putative PBP binding loops; other site 1114970014943 ABC-ATPase subunit interface; other site 1114970014944 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1114970014945 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1114970014946 betaine aldehyde dehydrogenase; Region: PLN02467 1114970014947 Arabidopsis betaine aldehyde dehydrogenase 1 and 2, ALDH family 10A8 and 10A9-like; Region: ALDH_F10_BADH; cd07110 1114970014948 NAD(P) binding site [chemical binding]; other site 1114970014949 catalytic residues [active] 1114970014950 catalytic residues [active] 1114970014951 hypothetical protein; Provisional; Region: PRK07524 1114970014952 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1114970014953 PYR/PP interface [polypeptide binding]; other site 1114970014954 dimer interface [polypeptide binding]; other site 1114970014955 TPP binding site [chemical binding]; other site 1114970014956 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1114970014957 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1114970014958 TPP-binding site [chemical binding]; other site 1114970014959 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1114970014960 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970014961 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1114970014962 substrate binding pocket [chemical binding]; other site 1114970014963 dimerization interface [polypeptide binding]; other site 1114970014964 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1114970014965 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1114970014966 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1114970014967 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1114970014968 THF binding site; other site 1114970014969 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1114970014970 substrate binding site [chemical binding]; other site 1114970014971 THF binding site; other site 1114970014972 zinc-binding site [ion binding]; other site 1114970014973 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 1114970014974 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970014975 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 1114970014976 putative dimerization interface [polypeptide binding]; other site 1114970014977 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1114970014978 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970014979 Coenzyme A binding pocket [chemical binding]; other site 1114970014980 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1114970014981 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1114970014982 nudix motif; other site 1114970014983 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1114970014984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970014985 active site 1114970014986 phosphorylation site [posttranslational modification] 1114970014987 intermolecular recognition site; other site 1114970014988 dimerization interface [polypeptide binding]; other site 1114970014989 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1114970014990 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970014991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970014992 active site 1114970014993 phosphorylation site [posttranslational modification] 1114970014994 intermolecular recognition site; other site 1114970014995 dimerization interface [polypeptide binding]; other site 1114970014996 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114970014997 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970014998 metal binding site [ion binding]; metal-binding site 1114970014999 active site 1114970015000 I-site; other site 1114970015001 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970015002 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970015003 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970015004 active site 1114970015005 phosphorylation site [posttranslational modification] 1114970015006 intermolecular recognition site; other site 1114970015007 dimerization interface [polypeptide binding]; other site 1114970015008 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114970015009 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970015010 metal binding site [ion binding]; metal-binding site 1114970015011 active site 1114970015012 I-site; other site 1114970015013 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970015014 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 1114970015015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970015016 ATP binding site [chemical binding]; other site 1114970015017 G-X-G motif; other site 1114970015018 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970015019 active site 1114970015020 phosphorylation site [posttranslational modification] 1114970015021 intermolecular recognition site; other site 1114970015022 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114970015023 dimerization interface [polypeptide binding]; other site 1114970015024 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970015025 dimer interface [polypeptide binding]; other site 1114970015026 phosphorylation site [posttranslational modification] 1114970015027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970015028 ATP binding site [chemical binding]; other site 1114970015029 Mg2+ binding site [ion binding]; other site 1114970015030 G-X-G motif; other site 1114970015031 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1114970015032 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1114970015033 active site 1114970015034 FMN binding site [chemical binding]; other site 1114970015035 substrate binding site [chemical binding]; other site 1114970015036 3Fe-4S cluster binding site [ion binding]; other site 1114970015037 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1114970015038 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1114970015039 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1114970015040 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1114970015041 Spore germination protein; Region: Spore_permease; cl17796 1114970015042 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1114970015043 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1114970015044 Transglycosylase; Region: Transgly; pfam00912 1114970015045 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1114970015046 putative fimbrial protein TcfA; Provisional; Region: PRK15308 1114970015047 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1114970015048 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 1114970015049 Predicted transcriptional regulators [Transcription]; Region: COG1695 1114970015050 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1114970015051 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1114970015052 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1114970015053 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1114970015054 FAD binding pocket [chemical binding]; other site 1114970015055 FAD binding motif [chemical binding]; other site 1114970015056 phosphate binding motif [ion binding]; other site 1114970015057 NAD binding pocket [chemical binding]; other site 1114970015058 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 1114970015059 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1114970015060 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970015061 ATP-grasp domain; Region: ATP-grasp; pfam02222 1114970015062 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1114970015063 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1114970015064 Trp docking motif [polypeptide binding]; other site 1114970015065 putative active site [active] 1114970015066 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 1114970015067 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 1114970015068 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1114970015069 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1114970015070 trimer interface [polypeptide binding]; other site 1114970015071 putative metal binding site [ion binding]; other site 1114970015072 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1114970015073 putative active site [active] 1114970015074 putative CoA binding site [chemical binding]; other site 1114970015075 nudix motif; other site 1114970015076 metal binding site [ion binding]; metal-binding site 1114970015077 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 1114970015078 nudix motif; other site 1114970015079 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1114970015080 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 1114970015081 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1114970015082 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1114970015083 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1114970015084 dimerization interface [polypeptide binding]; other site 1114970015085 ATP binding site [chemical binding]; other site 1114970015086 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1114970015087 dimerization interface [polypeptide binding]; other site 1114970015088 ATP binding site [chemical binding]; other site 1114970015089 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1114970015090 putative active site [active] 1114970015091 catalytic triad [active] 1114970015092 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 1114970015093 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970015094 substrate binding pocket [chemical binding]; other site 1114970015095 membrane-bound complex binding site; other site 1114970015096 hinge residues; other site 1114970015097 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1114970015098 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1114970015099 catalytic residue [active] 1114970015100 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1114970015101 active site 1114970015102 hydrophilic channel; other site 1114970015103 dimerization interface [polypeptide binding]; other site 1114970015104 catalytic residues [active] 1114970015105 active site lid [active] 1114970015106 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1114970015107 Recombination protein O N terminal; Region: RecO_N; pfam11967 1114970015108 Recombination protein O C terminal; Region: RecO_C; pfam02565 1114970015109 GTPase Era; Reviewed; Region: era; PRK00089 1114970015110 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1114970015111 G1 box; other site 1114970015112 GTP/Mg2+ binding site [chemical binding]; other site 1114970015113 Switch I region; other site 1114970015114 G2 box; other site 1114970015115 Switch II region; other site 1114970015116 G3 box; other site 1114970015117 G4 box; other site 1114970015118 G5 box; other site 1114970015119 KH domain; Region: KH_2; pfam07650 1114970015120 ribonuclease III; Reviewed; Region: rnc; PRK00102 1114970015121 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1114970015122 dimerization interface [polypeptide binding]; other site 1114970015123 active site 1114970015124 metal binding site [ion binding]; metal-binding site 1114970015125 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1114970015126 dsRNA binding site [nucleotide binding]; other site 1114970015127 signal peptidase I; Provisional; Region: PRK10861 1114970015128 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1114970015129 Catalytic site [active] 1114970015130 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1114970015131 GTP-binding protein LepA; Provisional; Region: PRK05433 1114970015132 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1114970015133 G1 box; other site 1114970015134 putative GEF interaction site [polypeptide binding]; other site 1114970015135 GTP/Mg2+ binding site [chemical binding]; other site 1114970015136 Switch I region; other site 1114970015137 G2 box; other site 1114970015138 G3 box; other site 1114970015139 Switch II region; other site 1114970015140 G4 box; other site 1114970015141 G5 box; other site 1114970015142 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1114970015143 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1114970015144 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1114970015145 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1114970015146 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1114970015147 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1114970015148 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1114970015149 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1114970015150 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1114970015151 interface (dimer of trimers) [polypeptide binding]; other site 1114970015152 Substrate-binding/catalytic site; other site 1114970015153 Zn-binding sites [ion binding]; other site 1114970015154 DNA polymerase III subunit chi; Validated; Region: PRK05728 1114970015155 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1114970015156 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1114970015157 HIGH motif; other site 1114970015158 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1114970015159 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1114970015160 active site 1114970015161 KMSKS motif; other site 1114970015162 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1114970015163 tRNA binding surface [nucleotide binding]; other site 1114970015164 anticodon binding site; other site 1114970015165 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1114970015166 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 1114970015167 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970015168 S-adenosylmethionine binding site [chemical binding]; other site 1114970015169 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1114970015170 IHF - DNA interface [nucleotide binding]; other site 1114970015171 IHF dimer interface [polypeptide binding]; other site 1114970015172 Nucleoid-associated protein [General function prediction only]; Region: COG3081 1114970015173 nucleoid-associated protein NdpA; Validated; Region: PRK00378 1114970015174 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1114970015175 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1114970015176 C-terminal domain interface [polypeptide binding]; other site 1114970015177 GSH binding site (G-site) [chemical binding]; other site 1114970015178 dimer interface [polypeptide binding]; other site 1114970015179 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1114970015180 N-terminal domain interface [polypeptide binding]; other site 1114970015181 substrate binding pocket (H-site) [chemical binding]; other site 1114970015182 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1114970015183 GIY-YIG motif/motif A; other site 1114970015184 putative active site [active] 1114970015185 putative metal binding site [ion binding]; other site 1114970015186 SnoaL-like domain; Region: SnoaL_3; pfam13474 1114970015187 SnoaL-like domain; Region: SnoaL_2; pfam12680 1114970015188 cyanate transporter; Region: CynX; TIGR00896 1114970015189 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970015190 putative substrate translocation pore; other site 1114970015191 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1114970015192 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970015193 DNA-binding site [nucleotide binding]; DNA binding site 1114970015194 FCD domain; Region: FCD; pfam07729 1114970015195 Motility quorum-sensing regulator (MqsR); Region: MqsR; cd12869 1114970015196 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 1114970015197 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114970015198 non-specific DNA binding site [nucleotide binding]; other site 1114970015199 salt bridge; other site 1114970015200 sequence-specific DNA binding site [nucleotide binding]; other site 1114970015201 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1114970015202 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1114970015203 Walker A/P-loop; other site 1114970015204 ATP binding site [chemical binding]; other site 1114970015205 Q-loop/lid; other site 1114970015206 ABC transporter signature motif; other site 1114970015207 Walker B; other site 1114970015208 D-loop; other site 1114970015209 H-loop/switch region; other site 1114970015210 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114970015211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970015212 dimer interface [polypeptide binding]; other site 1114970015213 conserved gate region; other site 1114970015214 putative PBP binding loops; other site 1114970015215 ABC-ATPase subunit interface; other site 1114970015216 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 1114970015217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970015218 conserved gate region; other site 1114970015219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970015220 dimer interface [polypeptide binding]; other site 1114970015221 ABC-ATPase subunit interface; other site 1114970015222 putative PBP binding loops; other site 1114970015223 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970015224 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1114970015225 substrate binding pocket [chemical binding]; other site 1114970015226 membrane-bound complex binding site; other site 1114970015227 hinge residues; other site 1114970015228 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1114970015229 putative hydrolase; Provisional; Region: PRK11460 1114970015230 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK01297 1114970015231 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1114970015232 ATP binding site [chemical binding]; other site 1114970015233 Mg++ binding site [ion binding]; other site 1114970015234 motif III; other site 1114970015235 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114970015236 nucleotide binding region [chemical binding]; other site 1114970015237 ATP-binding site [chemical binding]; other site 1114970015238 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1114970015239 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1114970015240 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1114970015241 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1114970015242 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1114970015243 YheO-like PAS domain; Region: PAS_6; pfam08348 1114970015244 HTH domain; Region: HTH_22; pfam13309 1114970015245 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1114970015246 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970015247 substrate binding pocket [chemical binding]; other site 1114970015248 membrane-bound complex binding site; other site 1114970015249 hinge residues; other site 1114970015250 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1114970015251 MoaE homodimer interface [polypeptide binding]; other site 1114970015252 MoaD interaction [polypeptide binding]; other site 1114970015253 active site residues [active] 1114970015254 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1114970015255 MoaE interaction surface [polypeptide binding]; other site 1114970015256 MoeB interaction surface [polypeptide binding]; other site 1114970015257 thiocarboxylated glycine; other site 1114970015258 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1114970015259 trimer interface [polypeptide binding]; other site 1114970015260 dimer interface [polypeptide binding]; other site 1114970015261 putative active site [active] 1114970015262 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1114970015263 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1114970015264 putative active site [active] 1114970015265 PhoH-like protein; Region: PhoH; pfam02562 1114970015266 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1114970015267 NodB motif; other site 1114970015268 active site 1114970015269 catalytic site [active] 1114970015270 metal binding site [ion binding]; metal-binding site 1114970015271 hypothetical protein; Validated; Region: PRK02101 1114970015272 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 1114970015273 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1114970015274 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1114970015275 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1114970015276 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1114970015277 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1114970015278 PilZ domain; Region: PilZ; pfam07238 1114970015279 HlyD family secretion protein; Region: HlyD_3; pfam13437 1114970015280 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1114970015281 Right handed beta helix region; Region: Beta_helix; pfam13229 1114970015282 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 1114970015283 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cd00244 1114970015284 active site 1114970015285 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1114970015286 Alginate O-acetyl transferase AlgF; Region: AlgF; pfam11182 1114970015287 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1114970015288 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1114970015289 Substrate binding site; other site 1114970015290 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1114970015291 short chain dehydrogenase; Provisional; Region: PRK05693 1114970015292 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1114970015293 NADP binding site [chemical binding]; other site 1114970015294 active site 1114970015295 steroid binding site; other site 1114970015296 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1114970015297 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1114970015298 HlyD family secretion protein; Region: HlyD_3; pfam13437 1114970015299 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 1114970015300 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1114970015301 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1114970015302 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1114970015303 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970015304 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970015305 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1114970015306 putative effector binding pocket; other site 1114970015307 dimerization interface [polypeptide binding]; other site 1114970015308 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1114970015309 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1114970015310 HlyD family secretion protein; Region: HlyD_3; pfam13437 1114970015311 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1114970015312 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1114970015313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970015314 active site 1114970015315 phosphorylation site [posttranslational modification] 1114970015316 intermolecular recognition site; other site 1114970015317 dimerization interface [polypeptide binding]; other site 1114970015318 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970015319 DNA binding site [nucleotide binding] 1114970015320 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1114970015321 HAMP domain; Region: HAMP; pfam00672 1114970015322 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970015323 dimer interface [polypeptide binding]; other site 1114970015324 phosphorylation site [posttranslational modification] 1114970015325 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970015326 ATP binding site [chemical binding]; other site 1114970015327 Mg2+ binding site [ion binding]; other site 1114970015328 G-X-G motif; other site 1114970015329 Cache domain; Region: Cache_1; pfam02743 1114970015330 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114970015331 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970015332 metal binding site [ion binding]; metal-binding site 1114970015333 active site 1114970015334 I-site; other site 1114970015335 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1114970015336 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1114970015337 cell division protein FtsZ; Validated; Region: PRK09330 1114970015338 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1114970015339 nucleotide binding site [chemical binding]; other site 1114970015340 SulA interaction site; other site 1114970015341 cell division protein FtsA; Region: ftsA; TIGR01174 1114970015342 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1114970015343 nucleotide binding site [chemical binding]; other site 1114970015344 Cell division protein FtsA; Region: FtsA; pfam14450 1114970015345 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1114970015346 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1114970015347 Cell division protein FtsQ; Region: FtsQ; pfam03799 1114970015348 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1114970015349 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1114970015350 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1114970015351 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1114970015352 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1114970015353 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1114970015354 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1114970015355 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1114970015356 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1114970015357 active site 1114970015358 homodimer interface [polypeptide binding]; other site 1114970015359 cell division protein FtsW; Region: ftsW; TIGR02614 1114970015360 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 1114970015361 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970015362 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1114970015363 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1114970015364 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1114970015365 Mg++ binding site [ion binding]; other site 1114970015366 putative catalytic motif [active] 1114970015367 putative substrate binding site [chemical binding]; other site 1114970015368 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1114970015369 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 1114970015370 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1114970015371 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1114970015372 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1114970015373 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1114970015374 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1114970015375 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1114970015376 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1114970015377 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1114970015378 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1114970015379 Cell division protein FtsL; Region: FtsL; pfam04999 1114970015380 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1114970015381 MraW methylase family; Region: Methyltransf_5; pfam01795 1114970015382 cell division protein MraZ; Reviewed; Region: PRK00326 1114970015383 MraZ protein; Region: MraZ; pfam02381 1114970015384 Predicted methyltransferases [General function prediction only]; Region: COG0313 1114970015385 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1114970015386 putative SAM binding site [chemical binding]; other site 1114970015387 putative homodimer interface [polypeptide binding]; other site 1114970015388 LppC putative lipoprotein; Region: LppC; pfam04348 1114970015389 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1114970015390 putative ligand binding site [chemical binding]; other site 1114970015391 hypothetical protein; Reviewed; Region: PRK12497 1114970015392 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1114970015393 dimer interface [polypeptide binding]; other site 1114970015394 active site 1114970015395 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1114970015396 BON domain; Region: BON; pfam04972 1114970015397 BON domain; Region: BON; pfam04972 1114970015398 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 1114970015399 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 1114970015400 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1114970015401 C-terminal domain interface [polypeptide binding]; other site 1114970015402 putative GSH binding site (G-site) [chemical binding]; other site 1114970015403 dimer interface [polypeptide binding]; other site 1114970015404 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1114970015405 dimer interface [polypeptide binding]; other site 1114970015406 N-terminal domain interface [polypeptide binding]; other site 1114970015407 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 1114970015408 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1114970015409 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1114970015410 Qi binding site; other site 1114970015411 intrachain domain interface; other site 1114970015412 interchain domain interface [polypeptide binding]; other site 1114970015413 heme bH binding site [chemical binding]; other site 1114970015414 heme bL binding site [chemical binding]; other site 1114970015415 Qo binding site; other site 1114970015416 interchain domain interface [polypeptide binding]; other site 1114970015417 intrachain domain interface; other site 1114970015418 Qi binding site; other site 1114970015419 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 1114970015420 Qo binding site; other site 1114970015421 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 1114970015422 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 1114970015423 [2Fe-2S] cluster binding site [ion binding]; other site 1114970015424 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1114970015425 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1114970015426 23S rRNA interface [nucleotide binding]; other site 1114970015427 L3 interface [polypeptide binding]; other site 1114970015428 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114970015429 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1114970015430 active site 1114970015431 catalytic tetrad [active] 1114970015432 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1114970015433 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1114970015434 active site 1114970015435 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1114970015436 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 1114970015437 conserved cys residue [active] 1114970015438 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970015439 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970015440 Predicted ATPase [General function prediction only]; Region: COG1485 1114970015441 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284 1114970015442 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1114970015443 active site 1114970015444 HIGH motif; other site 1114970015445 dimer interface [polypeptide binding]; other site 1114970015446 KMSKS motif; other site 1114970015447 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 1114970015448 Protein of unknown function (DUF1043); Region: DUF1043; cl11473 1114970015449 hypothetical protein; Provisional; Region: PRK07482 1114970015450 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114970015451 inhibitor-cofactor binding pocket; inhibition site 1114970015452 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970015453 catalytic residue [active] 1114970015454 succinic semialdehyde dehydrogenase; Region: PLN02278 1114970015455 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1114970015456 tetramerization interface [polypeptide binding]; other site 1114970015457 NAD(P) binding site [chemical binding]; other site 1114970015458 catalytic residues [active] 1114970015459 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1114970015460 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114970015461 putative DNA binding site [nucleotide binding]; other site 1114970015462 putative Zn2+ binding site [ion binding]; other site 1114970015463 AsnC family; Region: AsnC_trans_reg; pfam01037 1114970015464 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 1114970015465 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 1114970015466 putative active site [active] 1114970015467 Zn binding site [ion binding]; other site 1114970015468 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 1114970015469 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1114970015470 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1114970015471 active site 1114970015472 ectoine utilization protein EutC; Validated; Region: PRK08291 1114970015473 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1114970015474 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1114970015475 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1114970015476 tetramer interface [polypeptide binding]; other site 1114970015477 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970015478 catalytic residue [active] 1114970015479 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1114970015480 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970015481 DNA-binding site [nucleotide binding]; DNA binding site 1114970015482 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970015483 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970015484 homodimer interface [polypeptide binding]; other site 1114970015485 catalytic residue [active] 1114970015486 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 1114970015487 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970015488 substrate binding pocket [chemical binding]; other site 1114970015489 membrane-bound complex binding site; other site 1114970015490 hinge residues; other site 1114970015491 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114970015492 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970015493 dimer interface [polypeptide binding]; other site 1114970015494 conserved gate region; other site 1114970015495 putative PBP binding loops; other site 1114970015496 ABC-ATPase subunit interface; other site 1114970015497 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970015498 dimer interface [polypeptide binding]; other site 1114970015499 conserved gate region; other site 1114970015500 putative PBP binding loops; other site 1114970015501 ABC-ATPase subunit interface; other site 1114970015502 ectoine/hydroxyectoine ABC transporter, ATP-binding protein; Region: ectoine_ehuA; TIGR03005 1114970015503 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1114970015504 Walker A/P-loop; other site 1114970015505 ATP binding site [chemical binding]; other site 1114970015506 Q-loop/lid; other site 1114970015507 ABC transporter signature motif; other site 1114970015508 Walker B; other site 1114970015509 D-loop; other site 1114970015510 H-loop/switch region; other site 1114970015511 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1114970015512 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1114970015513 ligand binding site [chemical binding]; other site 1114970015514 acetylornithine aminotransferase; Provisional; Region: PRK02627 1114970015515 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114970015516 inhibitor-cofactor binding pocket; inhibition site 1114970015517 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970015518 catalytic residue [active] 1114970015519 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970015520 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970015521 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 1114970015522 putative effector binding pocket; other site 1114970015523 putative dimerization interface [polypeptide binding]; other site 1114970015524 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970015525 PAS fold; Region: PAS_3; pfam08447 1114970015526 putative active site [active] 1114970015527 heme pocket [chemical binding]; other site 1114970015528 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114970015529 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970015530 metal binding site [ion binding]; metal-binding site 1114970015531 active site 1114970015532 I-site; other site 1114970015533 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114970015534 non-specific DNA binding site [nucleotide binding]; other site 1114970015535 salt bridge; other site 1114970015536 sequence-specific DNA binding site [nucleotide binding]; other site 1114970015537 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 1114970015538 UbiA prenyltransferase family; Region: UbiA; pfam01040 1114970015539 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 1114970015540 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1114970015541 Subunit I/III interface [polypeptide binding]; other site 1114970015542 Subunit III/IV interface [polypeptide binding]; other site 1114970015543 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1114970015544 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1114970015545 D-pathway; other site 1114970015546 Putative ubiquinol binding site [chemical binding]; other site 1114970015547 Low-spin heme (heme b) binding site [chemical binding]; other site 1114970015548 Putative water exit pathway; other site 1114970015549 Binuclear center (heme o3/CuB) [ion binding]; other site 1114970015550 K-pathway; other site 1114970015551 Putative proton exit pathway; other site 1114970015552 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 1114970015553 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1114970015554 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1114970015555 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 1114970015556 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1114970015557 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1114970015558 heme-binding site [chemical binding]; other site 1114970015559 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1114970015560 FAD binding pocket [chemical binding]; other site 1114970015561 FAD binding motif [chemical binding]; other site 1114970015562 phosphate binding motif [ion binding]; other site 1114970015563 beta-alpha-beta structure motif; other site 1114970015564 NAD binding pocket [chemical binding]; other site 1114970015565 Heme binding pocket [chemical binding]; other site 1114970015566 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 1114970015567 GAF domain; Region: GAF; pfam01590 1114970015568 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970015569 Walker A motif; other site 1114970015570 ATP binding site [chemical binding]; other site 1114970015571 Walker B motif; other site 1114970015572 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1114970015573 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1114970015574 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970015575 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970015576 active site 1114970015577 phosphorylation site [posttranslational modification] 1114970015578 intermolecular recognition site; other site 1114970015579 dimerization interface [polypeptide binding]; other site 1114970015580 Flagellin N-methylase; Region: FliB; pfam03692 1114970015581 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1114970015582 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1114970015583 dimerization interface [polypeptide binding]; other site 1114970015584 ligand binding site [chemical binding]; other site 1114970015585 NADP binding site [chemical binding]; other site 1114970015586 catalytic site [active] 1114970015587 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1114970015588 EamA-like transporter family; Region: EamA; pfam00892 1114970015589 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970015590 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114970015591 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970015592 RNA polymerase sigma factor; Provisional; Region: PRK12528 1114970015593 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970015594 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1114970015595 fec operon regulator FecR; Reviewed; Region: PRK09774 1114970015596 FecR protein; Region: FecR; pfam04773 1114970015597 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 1114970015598 Secretin and TonB N terminus short domain; Region: STN; smart00965 1114970015599 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970015600 N-terminal plug; other site 1114970015601 ligand-binding site [chemical binding]; other site 1114970015602 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 1114970015603 30S subunit binding site; other site 1114970015604 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 1114970015605 Predicted membrane protein [Function unknown]; Region: COG3223 1114970015606 YebG protein; Region: YebG; pfam07130 1114970015607 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1114970015608 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970015609 DNA-binding site [nucleotide binding]; DNA binding site 1114970015610 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970015611 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970015612 homodimer interface [polypeptide binding]; other site 1114970015613 catalytic residue [active] 1114970015614 Benzoate membrane transport protein; Region: BenE; pfam03594 1114970015615 benzoate transporter; Region: benE; TIGR00843 1114970015616 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1114970015617 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1114970015618 homotrimer interaction site [polypeptide binding]; other site 1114970015619 putative active site [active] 1114970015620 threonine synthase; Validated; Region: PRK06260 1114970015621 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1114970015622 homodimer interface [polypeptide binding]; other site 1114970015623 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970015624 catalytic residue [active] 1114970015625 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1114970015626 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1114970015627 dimer interface [polypeptide binding]; other site 1114970015628 active site 1114970015629 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1114970015630 folate binding site [chemical binding]; other site 1114970015631 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1114970015632 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1114970015633 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1114970015634 NAD binding site [chemical binding]; other site 1114970015635 Phe binding site; other site 1114970015636 Uncharacterized conserved protein [Function unknown]; Region: COG2912 1114970015637 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1114970015638 maleylacetoacetate isomerase; Region: maiA; TIGR01262 1114970015639 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1114970015640 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 1114970015641 dimer interface [polypeptide binding]; other site 1114970015642 N-terminal domain interface [polypeptide binding]; other site 1114970015643 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 1114970015644 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 1114970015645 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 1114970015646 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1114970015647 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 1114970015648 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1114970015649 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1114970015650 Bacterial transcriptional regulator; Region: IclR; pfam01614 1114970015651 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1114970015652 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970015653 DNA binding residues [nucleotide binding] 1114970015654 dimerization interface [polypeptide binding]; other site 1114970015655 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1114970015656 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1114970015657 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1114970015658 S-type Pyocin; Region: Pyocin_S; pfam06958 1114970015659 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1114970015660 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1114970015661 amidase catalytic site [active] 1114970015662 Zn binding residues [ion binding]; other site 1114970015663 substrate binding site [chemical binding]; other site 1114970015664 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1114970015665 homodimer interface [polypeptide binding]; other site 1114970015666 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1114970015667 NAD binding site [chemical binding]; other site 1114970015668 active site 1114970015669 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1114970015670 aldolase II superfamily protein; Provisional; Region: PRK07044 1114970015671 intersubunit interface [polypeptide binding]; other site 1114970015672 active site 1114970015673 Zn2+ binding site [ion binding]; other site 1114970015674 flavodoxin; Provisional; Region: PRK05723 1114970015675 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970015676 PAS domain; Region: PAS_9; pfam13426 1114970015677 putative active site [active] 1114970015678 heme pocket [chemical binding]; other site 1114970015679 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1114970015680 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1114970015681 DNA binding residues [nucleotide binding] 1114970015682 B12 binding domain; Region: B12-binding_2; pfam02607 1114970015683 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 1114970015684 dihydromonapterin reductase; Provisional; Region: PRK06483 1114970015685 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970015686 NAD(P) binding site [chemical binding]; other site 1114970015687 active site 1114970015688 GTP cyclohydrolase I; Reviewed; Region: PRK12606 1114970015689 GTP cyclohydrolase I; Provisional; Region: PLN03044 1114970015690 active site 1114970015691 D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase; Provisional; Region: folX; PRK11245 1114970015692 active site 1114970015693 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 1114970015694 HopJ type III effector protein; Region: HopJ; pfam08888 1114970015695 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1114970015696 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114970015697 inhibitor-cofactor binding pocket; inhibition site 1114970015698 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970015699 catalytic residue [active] 1114970015700 thioredoxin reductase; Provisional; Region: PRK10262 1114970015701 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1114970015702 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114970015703 putative sulfate transport protein CysZ; Validated; Region: PRK04949 1114970015704 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114970015705 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1114970015706 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1114970015707 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 1114970015708 putative active site [active] 1114970015709 putative FMN binding site [chemical binding]; other site 1114970015710 putative substrate binding site [chemical binding]; other site 1114970015711 putative catalytic residue [active] 1114970015712 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1114970015713 catalytic residues [active] 1114970015714 dimer interface [polypeptide binding]; other site 1114970015715 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1114970015716 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1114970015717 Protein of unknown function (DUF3565); Region: DUF3565; pfam12088 1114970015718 phosphate acetyltransferase; Reviewed; Region: PRK05632 1114970015719 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1114970015720 DRTGG domain; Region: DRTGG; pfam07085 1114970015721 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1114970015722 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1114970015723 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1114970015724 putative acyl-acceptor binding pocket; other site 1114970015725 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1114970015726 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1114970015727 CysD dimerization site [polypeptide binding]; other site 1114970015728 G1 box; other site 1114970015729 putative GEF interaction site [polypeptide binding]; other site 1114970015730 GTP/Mg2+ binding site [chemical binding]; other site 1114970015731 Switch I region; other site 1114970015732 G2 box; other site 1114970015733 G3 box; other site 1114970015734 Switch II region; other site 1114970015735 G4 box; other site 1114970015736 G5 box; other site 1114970015737 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1114970015738 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1114970015739 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1114970015740 ligand-binding site [chemical binding]; other site 1114970015741 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1114970015742 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1114970015743 Active Sites [active] 1114970015744 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1114970015745 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1114970015746 serine endoprotease; Provisional; Region: PRK10898 1114970015747 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1114970015748 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1114970015749 protein binding site [polypeptide binding]; other site 1114970015750 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1114970015751 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970015752 N-terminal plug; other site 1114970015753 ligand-binding site [chemical binding]; other site 1114970015754 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 1114970015755 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1114970015756 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 1114970015757 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 1114970015758 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1114970015759 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1114970015760 putative acyl-acceptor binding pocket; other site 1114970015761 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 1114970015762 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1114970015763 putative transporter; Provisional; Region: PRK11660 1114970015764 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1114970015765 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1114970015766 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1114970015767 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 1114970015768 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114970015769 active site 1114970015770 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114970015771 active site 1114970015772 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1114970015773 ferrochelatase; Reviewed; Region: hemH; PRK00035 1114970015774 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1114970015775 C-terminal domain interface [polypeptide binding]; other site 1114970015776 active site 1114970015777 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1114970015778 active site 1114970015779 N-terminal domain interface [polypeptide binding]; other site 1114970015780 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1114970015781 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970015782 NAD(P) binding site [chemical binding]; other site 1114970015783 active site 1114970015784 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 1114970015785 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1114970015786 Protein of unknown function (DUF523); Region: DUF523; pfam04463 1114970015787 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1114970015788 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 1114970015789 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1114970015790 DNA binding residues [nucleotide binding] 1114970015791 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1114970015792 B12 binding domain; Region: B12-binding_2; pfam02607 1114970015793 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1114970015794 DNA photolyase; Region: DNA_photolyase; pfam00875 1114970015795 classical (c) SDRs; Region: SDR_c; cd05233 1114970015796 NAD(P) binding site [chemical binding]; other site 1114970015797 active site 1114970015798 Flagellin N-methylase; Region: FliB; pfam03692 1114970015799 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 1114970015800 glutamate racemase; Provisional; Region: PRK00865 1114970015801 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1114970015802 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1114970015803 ATP binding site [chemical binding]; other site 1114970015804 substrate interface [chemical binding]; other site 1114970015805 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1114970015806 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970015807 S-adenosylmethionine binding site [chemical binding]; other site 1114970015808 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1114970015809 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1114970015810 RF-1 domain; Region: RF-1; pfam00472 1114970015811 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1114970015812 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1114970015813 tRNA; other site 1114970015814 putative tRNA binding site [nucleotide binding]; other site 1114970015815 putative NADP binding site [chemical binding]; other site 1114970015816 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1114970015817 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114970015818 binding surface 1114970015819 TPR motif; other site 1114970015820 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114970015821 binding surface 1114970015822 TPR motif; other site 1114970015823 TPR repeat; Region: TPR_11; pfam13414 1114970015824 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114970015825 binding surface 1114970015826 TPR motif; other site 1114970015827 TPR repeat; Region: TPR_11; pfam13414 1114970015828 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 1114970015829 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1114970015830 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1114970015831 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1114970015832 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1114970015833 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1114970015834 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114970015835 active site 1114970015836 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1114970015837 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1114970015838 5S rRNA interface [nucleotide binding]; other site 1114970015839 CTC domain interface [polypeptide binding]; other site 1114970015840 L16 interface [polypeptide binding]; other site 1114970015841 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1114970015842 putative active site [active] 1114970015843 catalytic residue [active] 1114970015844 GTP-binding protein YchF; Reviewed; Region: PRK09601 1114970015845 YchF GTPase; Region: YchF; cd01900 1114970015846 G1 box; other site 1114970015847 GTP/Mg2+ binding site [chemical binding]; other site 1114970015848 Switch I region; other site 1114970015849 G2 box; other site 1114970015850 Switch II region; other site 1114970015851 G3 box; other site 1114970015852 G4 box; other site 1114970015853 G5 box; other site 1114970015854 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1114970015855 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1114970015856 Cytochrome c; Region: Cytochrom_C; pfam00034 1114970015857 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1114970015858 Cache domain; Region: Cache_1; pfam02743 1114970015859 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1114970015860 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970015861 dimerization interface [polypeptide binding]; other site 1114970015862 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970015863 dimer interface [polypeptide binding]; other site 1114970015864 putative CheW interface [polypeptide binding]; other site 1114970015865 D-mannose binding lectin; Region: B_lectin; pfam01453 1114970015866 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 1114970015867 mannose binding site [chemical binding]; other site 1114970015868 dimerization interface [polypeptide binding]; other site 1114970015869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970015870 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970015871 putative substrate translocation pore; other site 1114970015872 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970015873 dimer interface [polypeptide binding]; other site 1114970015874 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1114970015875 putative CheW interface [polypeptide binding]; other site 1114970015876 The Death Domain Superfamily of protein-protein interaction domains; Region: DD_superfamily; cl14633 1114970015877 Fic family protein [Function unknown]; Region: COG3177 1114970015878 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 1114970015879 Fic/DOC family; Region: Fic; pfam02661 1114970015880 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1114970015881 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1114970015882 PAS domain; Region: PAS_9; pfam13426 1114970015883 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970015884 putative active site [active] 1114970015885 heme pocket [chemical binding]; other site 1114970015886 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970015887 PAS domain; Region: PAS_9; pfam13426 1114970015888 putative active site [active] 1114970015889 heme pocket [chemical binding]; other site 1114970015890 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970015891 dimer interface [polypeptide binding]; other site 1114970015892 putative CheW interface [polypeptide binding]; other site 1114970015893 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 1114970015894 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1114970015895 active site clefts [active] 1114970015896 zinc binding site [ion binding]; other site 1114970015897 dimer interface [polypeptide binding]; other site 1114970015898 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1114970015899 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1114970015900 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1114970015901 mce related protein; Region: MCE; pfam02470 1114970015902 mce related protein; Region: MCE; pfam02470 1114970015903 mce related protein; Region: MCE; pfam02470 1114970015904 mce related protein; Region: MCE; pfam02470 1114970015905 mce related protein; Region: MCE; pfam02470 1114970015906 mce related protein; Region: MCE; pfam02470 1114970015907 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 1114970015908 Paraquat-inducible protein A; Region: PqiA; pfam04403 1114970015909 Paraquat-inducible protein A; Region: PqiA; pfam04403 1114970015910 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1114970015911 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1114970015912 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1114970015913 Moco binding site; other site 1114970015914 metal coordination site [ion binding]; other site 1114970015915 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1114970015916 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1114970015917 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1114970015918 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1114970015919 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1114970015920 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1114970015921 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1114970015922 putative valine binding site [chemical binding]; other site 1114970015923 dimer interface [polypeptide binding]; other site 1114970015924 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1114970015925 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466 1114970015926 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1114970015927 PYR/PP interface [polypeptide binding]; other site 1114970015928 dimer interface [polypeptide binding]; other site 1114970015929 TPP binding site [chemical binding]; other site 1114970015930 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1114970015931 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1114970015932 TPP-binding site [chemical binding]; other site 1114970015933 dimer interface [polypeptide binding]; other site 1114970015934 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1114970015935 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 1114970015936 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114970015937 TPR motif; other site 1114970015938 binding surface 1114970015939 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 1114970015940 Transglycosylase; Region: Transgly; pfam00912 1114970015941 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1114970015942 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1114970015943 AAA domain; Region: AAA_33; pfam13671 1114970015944 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1114970015945 ATP-binding site [chemical binding]; other site 1114970015946 Gluconate-6-phosphate binding site [chemical binding]; other site 1114970015947 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1114970015948 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1114970015949 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1114970015950 TfoX C-terminal domain; Region: TfoX_C; pfam04994 1114970015951 Protein of unknown function, DUF399; Region: DUF399; cl01139 1114970015952 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1114970015953 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1114970015954 Walker A/P-loop; other site 1114970015955 ATP binding site [chemical binding]; other site 1114970015956 Q-loop/lid; other site 1114970015957 ABC transporter signature motif; other site 1114970015958 Walker B; other site 1114970015959 D-loop; other site 1114970015960 H-loop/switch region; other site 1114970015961 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1114970015962 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114970015963 ABC-ATPase subunit interface; other site 1114970015964 dimer interface [polypeptide binding]; other site 1114970015965 putative PBP binding regions; other site 1114970015966 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1114970015967 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1114970015968 intersubunit interface [polypeptide binding]; other site 1114970015969 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1114970015970 iron-sulfur cluster [ion binding]; other site 1114970015971 [2Fe-2S] cluster binding site [ion binding]; other site 1114970015972 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1114970015973 hypothetical protein; Provisional; Region: PRK08960 1114970015974 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970015975 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970015976 homodimer interface [polypeptide binding]; other site 1114970015977 catalytic residue [active] 1114970015978 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 1114970015979 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 1114970015980 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1114970015981 active site 1114970015982 HIGH motif; other site 1114970015983 nucleotide binding site [chemical binding]; other site 1114970015984 KMSKS motif; other site 1114970015985 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 1114970015986 Na binding site [ion binding]; other site 1114970015987 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1114970015988 PAS domain; Region: PAS; smart00091 1114970015989 putative active site [active] 1114970015990 heme pocket [chemical binding]; other site 1114970015991 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970015992 dimer interface [polypeptide binding]; other site 1114970015993 phosphorylation site [posttranslational modification] 1114970015994 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970015995 ATP binding site [chemical binding]; other site 1114970015996 Mg2+ binding site [ion binding]; other site 1114970015997 G-X-G motif; other site 1114970015998 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1114970015999 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970016000 active site 1114970016001 phosphorylation site [posttranslational modification] 1114970016002 intermolecular recognition site; other site 1114970016003 dimerization interface [polypeptide binding]; other site 1114970016004 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970016005 Walker A motif; other site 1114970016006 ATP binding site [chemical binding]; other site 1114970016007 Walker B motif; other site 1114970016008 arginine finger; other site 1114970016009 poly(A) polymerase; Region: pcnB; TIGR01942 1114970016010 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1114970016011 active site 1114970016012 NTP binding site [chemical binding]; other site 1114970016013 metal binding triad [ion binding]; metal-binding site 1114970016014 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1114970016015 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1114970016016 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1114970016017 catalytic center binding site [active] 1114970016018 ATP binding site [chemical binding]; other site 1114970016019 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1114970016020 oligomerization interface [polypeptide binding]; other site 1114970016021 active site 1114970016022 metal binding site [ion binding]; metal-binding site 1114970016023 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1114970016024 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1114970016025 active site 1114970016026 ATP-binding site [chemical binding]; other site 1114970016027 pantoate-binding site; other site 1114970016028 HXXH motif; other site 1114970016029 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1114970016030 tetramerization interface [polypeptide binding]; other site 1114970016031 active site 1114970016032 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1114970016033 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1114970016034 active site 1114970016035 dimer interface [polypeptide binding]; other site 1114970016036 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1114970016037 dimer interface [polypeptide binding]; other site 1114970016038 active site 1114970016039 acetyl-CoA synthetase; Provisional; Region: PRK00174 1114970016040 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1114970016041 active site 1114970016042 CoA binding site [chemical binding]; other site 1114970016043 acyl-activating enzyme (AAE) consensus motif; other site 1114970016044 AMP binding site [chemical binding]; other site 1114970016045 acetate binding site [chemical binding]; other site 1114970016046 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1114970016047 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1114970016048 putative RNA binding site [nucleotide binding]; other site 1114970016049 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1114970016050 S-adenosylmethionine binding site [chemical binding]; other site 1114970016051 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1114970016052 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1114970016053 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1114970016054 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 1114970016055 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 1114970016056 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1114970016057 Pilin (bacterial filament); Region: Pilin; pfam00114 1114970016058 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 1114970016059 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1114970016060 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1114970016061 Walker A motif; other site 1114970016062 ATP binding site [chemical binding]; other site 1114970016063 Walker B motif; other site 1114970016064 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1114970016065 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1114970016066 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1114970016067 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1114970016068 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1114970016069 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1114970016070 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1114970016071 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1114970016072 CoA-binding site [chemical binding]; other site 1114970016073 ATP-binding [chemical binding]; other site 1114970016074 Domain of unknown function (DUF329); Region: DUF329; cl01144 1114970016075 Predicted membrane protein [Function unknown]; Region: COG3235 1114970016076 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1114970016077 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1114970016078 active site 1 [active] 1114970016079 dimer interface [polypeptide binding]; other site 1114970016080 hexamer interface [polypeptide binding]; other site 1114970016081 active site 2 [active] 1114970016082 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1114970016083 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970016084 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1114970016085 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970016086 dimerization interface [polypeptide binding]; other site 1114970016087 Protein of unknown function (DUF1780); Region: DUF1780; pfam08682 1114970016088 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1114970016089 MOSC domain; Region: MOSC; pfam03473 1114970016090 Protein of unknown function (DUF3094); Region: DUF3094; pfam11293 1114970016091 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1114970016092 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114970016093 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1114970016094 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970016095 dimerization interface [polypeptide binding]; other site 1114970016096 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970016097 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970016098 dimer interface [polypeptide binding]; other site 1114970016099 putative CheW interface [polypeptide binding]; other site 1114970016100 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1114970016101 Clp amino terminal domain; Region: Clp_N; pfam02861 1114970016102 Clp amino terminal domain; Region: Clp_N; pfam02861 1114970016103 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970016104 Walker A motif; other site 1114970016105 ATP binding site [chemical binding]; other site 1114970016106 Walker B motif; other site 1114970016107 arginine finger; other site 1114970016108 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970016109 Walker A motif; other site 1114970016110 ATP binding site [chemical binding]; other site 1114970016111 Walker B motif; other site 1114970016112 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1114970016113 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1114970016114 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1114970016115 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1114970016116 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1114970016117 RNA binding surface [nucleotide binding]; other site 1114970016118 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1114970016119 active site 1114970016120 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 1114970016121 Phage shock protein G (Phageshock_PspG); Region: Phageshock_PspG; pfam09583 1114970016122 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 1114970016123 PAS domain; Region: PAS; smart00091 1114970016124 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970016125 dimer interface [polypeptide binding]; other site 1114970016126 phosphorylation site [posttranslational modification] 1114970016127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970016128 ATP binding site [chemical binding]; other site 1114970016129 Mg2+ binding site [ion binding]; other site 1114970016130 G-X-G motif; other site 1114970016131 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1114970016132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970016133 active site 1114970016134 phosphorylation site [posttranslational modification] 1114970016135 intermolecular recognition site; other site 1114970016136 dimerization interface [polypeptide binding]; other site 1114970016137 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970016138 Walker A motif; other site 1114970016139 ATP binding site [chemical binding]; other site 1114970016140 Walker B motif; other site 1114970016141 arginine finger; other site 1114970016142 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1114970016143 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1114970016144 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1114970016145 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 1114970016146 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 1114970016147 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 1114970016148 PilX N-terminal; Region: PilX_N; pfam14341 1114970016149 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 1114970016150 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 1114970016151 Type II transport protein GspH; Region: GspH; pfam12019 1114970016152 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 1114970016153 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1114970016154 Type II transport protein GspH; Region: GspH; pfam12019 1114970016155 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1114970016156 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1114970016157 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1114970016158 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1114970016159 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1114970016160 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1114970016161 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1114970016162 active site 1114970016163 HIGH motif; other site 1114970016164 nucleotide binding site [chemical binding]; other site 1114970016165 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1114970016166 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1114970016167 active site 1114970016168 KMSKS motif; other site 1114970016169 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1114970016170 tRNA binding surface [nucleotide binding]; other site 1114970016171 anticodon binding site; other site 1114970016172 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1114970016173 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1114970016174 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1114970016175 Riboflavin kinase; Region: Flavokinase; smart00904 1114970016176 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1114970016177 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1114970016178 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1114970016179 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1114970016180 CreA protein; Region: CreA; pfam05981 1114970016181 gamma-glutamyl kinase; Provisional; Region: PRK05429 1114970016182 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1114970016183 nucleotide binding site [chemical binding]; other site 1114970016184 homotetrameric interface [polypeptide binding]; other site 1114970016185 putative phosphate binding site [ion binding]; other site 1114970016186 putative allosteric binding site; other site 1114970016187 PUA domain; Region: PUA; pfam01472 1114970016188 GTPase CgtA; Reviewed; Region: obgE; PRK12298 1114970016189 GTP1/OBG; Region: GTP1_OBG; pfam01018 1114970016190 Obg GTPase; Region: Obg; cd01898 1114970016191 G1 box; other site 1114970016192 GTP/Mg2+ binding site [chemical binding]; other site 1114970016193 Switch I region; other site 1114970016194 G2 box; other site 1114970016195 G3 box; other site 1114970016196 Switch II region; other site 1114970016197 G4 box; other site 1114970016198 G5 box; other site 1114970016199 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1114970016200 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1114970016201 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1114970016202 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1114970016203 substrate binding pocket [chemical binding]; other site 1114970016204 chain length determination region; other site 1114970016205 substrate-Mg2+ binding site; other site 1114970016206 catalytic residues [active] 1114970016207 aspartate-rich region 1; other site 1114970016208 active site lid residues [active] 1114970016209 aspartate-rich region 2; other site 1114970016210 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1114970016211 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1114970016212 PhnA protein; Region: PhnA; pfam03831 1114970016213 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1114970016214 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1114970016215 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1114970016216 hypothetical protein; Provisional; Region: PRK05208 1114970016217 AAA domain; Region: AAA_32; pfam13654 1114970016218 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1114970016219 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 1114970016220 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 1114970016221 transcription elongation factor regulatory protein; Validated; Region: PRK06342 1114970016222 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1114970016223 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 1114970016224 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1114970016225 active site 1114970016226 zinc binding site [ion binding]; other site 1114970016227 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1114970016228 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1114970016229 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1114970016230 ABC transporter; Region: ABC_tran_2; pfam12848 1114970016231 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1114970016232 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1114970016233 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970016234 putative active site [active] 1114970016235 heme pocket [chemical binding]; other site 1114970016236 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970016237 putative active site [active] 1114970016238 heme pocket [chemical binding]; other site 1114970016239 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970016240 PAS domain; Region: PAS_9; pfam13426 1114970016241 putative active site [active] 1114970016242 heme pocket [chemical binding]; other site 1114970016243 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114970016244 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970016245 metal binding site [ion binding]; metal-binding site 1114970016246 active site 1114970016247 I-site; other site 1114970016248 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970016249 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1114970016250 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1114970016251 dimer interface [polypeptide binding]; other site 1114970016252 active site 1114970016253 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1114970016254 folate binding site [chemical binding]; other site 1114970016255 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027 1114970016256 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1114970016257 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1114970016258 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970016259 DNA-binding site [nucleotide binding]; DNA binding site 1114970016260 FCD domain; Region: FCD; pfam07729 1114970016261 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1114970016262 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970016263 DNA-binding site [nucleotide binding]; DNA binding site 1114970016264 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1114970016265 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 1114970016266 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1114970016267 P-loop, Walker A motif; other site 1114970016268 Base recognition motif; other site 1114970016269 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1114970016270 Uncharacterized small protein [Function unknown]; Region: COG2879 1114970016271 carbon starvation protein A; Provisional; Region: PRK15015 1114970016272 Carbon starvation protein CstA; Region: CstA; pfam02554 1114970016273 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1114970016274 DNA repair protein RadA; Provisional; Region: PRK11823 1114970016275 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1114970016276 Walker A motif; other site 1114970016277 ATP binding site [chemical binding]; other site 1114970016278 Walker B motif; other site 1114970016279 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1114970016280 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1114970016281 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1114970016282 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1114970016283 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1114970016284 tetramer interface [polypeptide binding]; other site 1114970016285 heme binding pocket [chemical binding]; other site 1114970016286 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 1114970016287 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1114970016288 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1114970016289 ferredoxin-NADP reductase; Provisional; Region: PRK10926 1114970016290 FAD binding pocket [chemical binding]; other site 1114970016291 FAD binding motif [chemical binding]; other site 1114970016292 phosphate binding motif [ion binding]; other site 1114970016293 beta-alpha-beta structure motif; other site 1114970016294 NAD binding pocket [chemical binding]; other site 1114970016295 transcriptional regulator TraR; Provisional; Region: PRK13870 1114970016296 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1114970016297 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970016298 DNA binding residues [nucleotide binding] 1114970016299 dimerization interface [polypeptide binding]; other site 1114970016300 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1114970016301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970016302 S-adenosylmethionine binding site [chemical binding]; other site 1114970016303 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 1114970016304 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1114970016305 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1114970016306 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1114970016307 H+ Antiporter protein; Region: 2A0121; TIGR00900 1114970016308 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970016309 putative substrate translocation pore; other site 1114970016310 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1114970016311 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1114970016312 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1114970016313 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1114970016314 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1114970016315 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1114970016316 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1114970016317 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 1114970016318 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1114970016319 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114970016320 sequence-specific DNA binding site [nucleotide binding]; other site 1114970016321 salt bridge; other site 1114970016322 DJ-1 family protein; Region: not_thiJ; TIGR01383 1114970016323 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1114970016324 conserved cys residue [active] 1114970016325 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1114970016326 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 1114970016327 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970016328 S-adenosylmethionine binding site [chemical binding]; other site 1114970016329 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1114970016330 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1114970016331 active site 1114970016332 trimer interface [polypeptide binding]; other site 1114970016333 dimer interface [polypeptide binding]; other site 1114970016334 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 1114970016335 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1114970016336 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1114970016337 shikimate binding site; other site 1114970016338 NAD(P) binding site [chemical binding]; other site 1114970016339 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970016340 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114970016341 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1114970016342 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 1114970016343 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1114970016344 dimer interface [polypeptide binding]; other site 1114970016345 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1114970016346 active site 1114970016347 Fe binding site [ion binding]; other site 1114970016348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970016349 D-galactonate transporter; Region: 2A0114; TIGR00893 1114970016350 putative substrate translocation pore; other site 1114970016351 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1114970016352 EamA-like transporter family; Region: EamA; cl17759 1114970016353 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1114970016354 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1114970016355 Bacterial transcriptional regulator; Region: IclR; pfam01614 1114970016356 Predicted metalloprotease [General function prediction only]; Region: COG2321 1114970016357 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1114970016358 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1114970016359 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114970016360 active site 1114970016361 motif I; other site 1114970016362 motif II; other site 1114970016363 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1114970016364 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1114970016365 active site 1114970016366 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1114970016367 catalytic triad [active] 1114970016368 dimer interface [polypeptide binding]; other site 1114970016369 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1114970016370 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1114970016371 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1114970016372 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970016373 DNA-binding site [nucleotide binding]; DNA binding site 1114970016374 FCD domain; Region: FCD; pfam07729 1114970016375 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1114970016376 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1114970016377 putative active site [active] 1114970016378 hypothetical protein; Provisional; Region: PRK05463 1114970016379 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1114970016380 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1114970016381 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1114970016382 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1114970016383 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1114970016384 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1114970016385 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1114970016386 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1114970016387 carboxyltransferase (CT) interaction site; other site 1114970016388 biotinylation site [posttranslational modification]; other site 1114970016389 outer membrane porin, OprD family; Region: OprD; pfam03573 1114970016390 Cache domain; Region: Cache_1; pfam02743 1114970016391 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1114970016392 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970016393 dimerization interface [polypeptide binding]; other site 1114970016394 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970016395 dimer interface [polypeptide binding]; other site 1114970016396 putative CheW interface [polypeptide binding]; other site 1114970016397 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1114970016398 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 1114970016399 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1114970016400 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1114970016401 ATP binding site [chemical binding]; other site 1114970016402 Mg++ binding site [ion binding]; other site 1114970016403 motif III; other site 1114970016404 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114970016405 nucleotide binding region [chemical binding]; other site 1114970016406 ATP-binding site [chemical binding]; other site 1114970016407 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1114970016408 EamA-like transporter family; Region: EamA; pfam00892 1114970016409 EamA-like transporter family; Region: EamA; pfam00892 1114970016410 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1114970016411 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114970016412 putative DNA binding site [nucleotide binding]; other site 1114970016413 putative Zn2+ binding site [ion binding]; other site 1114970016414 AsnC family; Region: AsnC_trans_reg; pfam01037 1114970016415 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1114970016416 active site 1114970016417 catalytic site [active] 1114970016418 substrate binding site [chemical binding]; other site 1114970016419 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1114970016420 LabA_like proteins; Region: LabA; cd10911 1114970016421 putative metal binding site [ion binding]; other site 1114970016422 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 1114970016423 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 1114970016424 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1114970016425 putative catalytic site [active] 1114970016426 putative metal binding site [ion binding]; other site 1114970016427 putative phosphate binding site [ion binding]; other site 1114970016428 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1114970016429 Transposase; Region: HTH_Tnp_1; pfam01527 1114970016430 Integrase core domain; Region: rve_3; cl15866 1114970016431 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 1114970016432 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114970016433 ATP binding site [chemical binding]; other site 1114970016434 putative Mg++ binding site [ion binding]; other site 1114970016435 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114970016436 nucleotide binding region [chemical binding]; other site 1114970016437 ATP-binding site [chemical binding]; other site 1114970016438 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 1114970016439 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1114970016440 Cation efflux family; Region: Cation_efflux; cl00316 1114970016441 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1114970016442 Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436 1114970016443 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1114970016444 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114970016445 putative DNA binding site [nucleotide binding]; other site 1114970016446 putative Zn2+ binding site [ion binding]; other site 1114970016447 AsnC family; Region: AsnC_trans_reg; pfam01037 1114970016448 Protein of unknown function (DUF2788); Region: DUF2788; pfam10981 1114970016449 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1114970016450 pseudouridine synthase; Region: TIGR00093 1114970016451 active site 1114970016452 AMP nucleosidase; Provisional; Region: PRK08292 1114970016453 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1114970016454 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1114970016455 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1114970016456 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1114970016457 active site 1114970016458 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1114970016459 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1114970016460 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114970016461 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970016462 dimer interface [polypeptide binding]; other site 1114970016463 phosphorylation site [posttranslational modification] 1114970016464 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970016465 ATP binding site [chemical binding]; other site 1114970016466 Mg2+ binding site [ion binding]; other site 1114970016467 G-X-G motif; other site 1114970016468 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970016469 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970016470 active site 1114970016471 phosphorylation site [posttranslational modification] 1114970016472 intermolecular recognition site; other site 1114970016473 dimerization interface [polypeptide binding]; other site 1114970016474 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1114970016475 dimer interface [polypeptide binding]; other site 1114970016476 substrate binding site [chemical binding]; other site 1114970016477 ATP binding site [chemical binding]; other site 1114970016478 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1114970016479 thiamine phosphate binding site [chemical binding]; other site 1114970016480 active site 1114970016481 pyrophosphate binding site [ion binding]; other site 1114970016482 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1114970016483 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114970016484 inhibitor-cofactor binding pocket; inhibition site 1114970016485 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970016486 catalytic residue [active] 1114970016487 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1114970016488 Sel1-like repeats; Region: SEL1; smart00671 1114970016489 Sel1-like repeats; Region: SEL1; smart00671 1114970016490 Domain of unknown function (DUF1820); Region: DUF1820; pfam08850 1114970016491 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1114970016492 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1114970016493 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114970016494 FeS/SAM binding site; other site 1114970016495 TRAM domain; Region: TRAM; pfam01938 1114970016496 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1114970016497 PhoH-like protein; Region: PhoH; pfam02562 1114970016498 metal-binding heat shock protein; Provisional; Region: PRK00016 1114970016499 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 1114970016500 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1114970016501 Transporter associated domain; Region: CorC_HlyC; smart01091 1114970016502 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1114970016503 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1114970016504 putative active site [active] 1114970016505 catalytic triad [active] 1114970016506 putative dimer interface [polypeptide binding]; other site 1114970016507 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1114970016508 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1114970016509 putative active site [active] 1114970016510 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1114970016511 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1114970016512 HIGH motif; other site 1114970016513 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1114970016514 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1114970016515 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1114970016516 active site 1114970016517 KMSKS motif; other site 1114970016518 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1114970016519 tRNA binding surface [nucleotide binding]; other site 1114970016520 Lipopolysaccharide-assembly; Region: LptE; cl01125 1114970016521 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1114970016522 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1114970016523 Domain of unknown function; Region: DUF331; cl01149 1114970016524 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1114970016525 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1114970016526 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1114970016527 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1114970016528 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1114970016529 dimer interface [polypeptide binding]; other site 1114970016530 catalytic triad [active] 1114970016531 lipoyl synthase; Provisional; Region: PRK05481 1114970016532 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114970016533 FeS/SAM binding site; other site 1114970016534 lipoate-protein ligase B; Provisional; Region: PRK14342 1114970016535 hypothetical protein; Provisional; Region: PRK00341 1114970016536 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1114970016537 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1114970016538 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1114970016539 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1114970016540 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1114970016541 Sporulation related domain; Region: SPOR; pfam05036 1114970016542 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1114970016543 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1114970016544 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1114970016545 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1114970016546 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1114970016547 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1114970016548 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1114970016549 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1114970016550 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1114970016551 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1114970016552 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1114970016553 active site 1114970016554 (T/H)XGH motif; other site 1114970016555 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1114970016556 putative catalytic cysteine [active] 1114970016557 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1114970016558 active site 1114970016559 DNA binding site [nucleotide binding] 1114970016560 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1114970016561 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1114970016562 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1114970016563 active site 1114970016564 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1114970016565 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1114970016566 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1114970016567 putative active site [active] 1114970016568 putative catalytic site [active] 1114970016569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 1114970016570 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 1114970016571 Peptidase C13 family; Region: Peptidase_C13; pfam01650 1114970016572 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 1114970016573 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1114970016574 NAD binding site [chemical binding]; other site 1114970016575 active site 1114970016576 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 1114970016577 aromatic acid decarboxylase; Validated; Region: PRK05920 1114970016578 Flavoprotein; Region: Flavoprotein; pfam02441 1114970016579 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1114970016580 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1114970016581 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1114970016582 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1114970016583 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1114970016584 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970016585 Walker A motif; other site 1114970016586 ATP binding site [chemical binding]; other site 1114970016587 Walker B motif; other site 1114970016588 arginine finger; other site 1114970016589 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1114970016590 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1114970016591 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970016592 NAD(P) binding site [chemical binding]; other site 1114970016593 catalytic residues [active] 1114970016594 ethanolamine permease; Region: 2A0305; TIGR00908 1114970016595 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 1114970016596 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1114970016597 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 1114970016598 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1114970016599 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970016600 Coenzyme A binding pocket [chemical binding]; other site 1114970016601 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1114970016602 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1114970016603 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 1114970016604 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1114970016605 dimer interface [polypeptide binding]; other site 1114970016606 substrate binding site [chemical binding]; other site 1114970016607 metal binding sites [ion binding]; metal-binding site 1114970016608 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114970016609 non-specific DNA binding site [nucleotide binding]; other site 1114970016610 salt bridge; other site 1114970016611 sequence-specific DNA binding site [nucleotide binding]; other site 1114970016612 Predicted transcriptional regulator [Transcription]; Region: COG2932 1114970016613 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1114970016614 Catalytic site [active] 1114970016615 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1114970016616 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1114970016617 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970016618 S-adenosylmethionine binding site [chemical binding]; other site 1114970016619 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1114970016620 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1114970016621 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 1114970016622 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1114970016623 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1114970016624 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 1114970016625 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1114970016626 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1114970016627 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1114970016628 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1114970016629 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1114970016630 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1114970016631 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1114970016632 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1114970016633 Transposase; Region: HTH_Tnp_1; pfam01527 1114970016634 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1114970016635 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114970016636 ATP binding site [chemical binding]; other site 1114970016637 putative Mg++ binding site [ion binding]; other site 1114970016638 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114970016639 nucleotide binding region [chemical binding]; other site 1114970016640 ATP-binding site [chemical binding]; other site 1114970016641 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1114970016642 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1114970016643 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 1114970016644 ligand binding site [chemical binding]; other site 1114970016645 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1114970016646 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 1114970016647 active site 1114970016648 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 1114970016649 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114970016650 NAD(P) binding site [chemical binding]; other site 1114970016651 catalytic residues [active] 1114970016652 homoserine dehydrogenase; Provisional; Region: PRK06270 1114970016653 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1114970016654 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1114970016655 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1114970016656 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1114970016657 AsnC family; Region: AsnC_trans_reg; pfam01037 1114970016658 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1114970016659 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1114970016660 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970016661 catalytic residue [active] 1114970016662 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1114970016663 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970016664 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1114970016665 dimerization interface [polypeptide binding]; other site 1114970016666 substrate binding pocket [chemical binding]; other site 1114970016667 S-methylmethionine transporter; Provisional; Region: PRK11387 1114970016668 cystathionine gamma-synthase; Provisional; Region: PRK08249 1114970016669 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1114970016670 homodimer interface [polypeptide binding]; other site 1114970016671 substrate-cofactor binding pocket; other site 1114970016672 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970016673 catalytic residue [active] 1114970016674 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1114970016675 RHS Repeat; Region: RHS_repeat; pfam05593 1114970016676 RHS Repeat; Region: RHS_repeat; pfam05593 1114970016677 RHS Repeat; Region: RHS_repeat; pfam05593 1114970016678 RHS Repeat; Region: RHS_repeat; pfam05593 1114970016679 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1114970016680 RHS Repeat; Region: RHS_repeat; pfam05593 1114970016681 RHS Repeat; Region: RHS_repeat; cl11982 1114970016682 RHS Repeat; Region: RHS_repeat; pfam05593 1114970016683 RHS protein; Region: RHS; pfam03527 1114970016684 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1114970016685 Pertussis toxin, subunit 1; Region: Pertussis_S1; cl03779 1114970016686 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970016687 Coenzyme A binding pocket [chemical binding]; other site 1114970016688 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1114970016689 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1114970016690 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1114970016691 Putative methyltransferase; Region: Methyltransf_20; pfam12147 1114970016692 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 1114970016693 active site 1114970016694 Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453 1114970016695 active site 1114970016696 catalytic residues [active] 1114970016697 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1114970016698 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1114970016699 putative acyl-acceptor binding pocket; other site 1114970016700 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 1114970016701 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1114970016702 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1114970016703 Protein of unknown function (DUF1190); Region: DUF1190; pfam06693 1114970016704 Predicted membrane protein [Function unknown]; Region: COG3766 1114970016705 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1114970016706 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 1114970016707 Ion channel; Region: Ion_trans_2; pfam07885 1114970016708 TrkA-N domain; Region: TrkA_N; pfam02254 1114970016709 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1114970016710 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; pfam09938 1114970016711 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 1114970016712 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 1114970016713 Predicted secreted protein [Function unknown]; Region: COG5445 1114970016714 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 1114970016715 Predicted secreted protein [Function unknown]; Region: COG5445 1114970016716 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 1114970016717 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1114970016718 MG2 domain; Region: A2M_N; pfam01835 1114970016719 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1114970016720 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1114970016721 surface patch; other site 1114970016722 thioester region; other site 1114970016723 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 1114970016724 Uncharacterized protein conserved in bacteria (DUF2138); Region: DUF2138; pfam09909 1114970016725 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 1114970016726 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 1114970016727 Fic family protein [Function unknown]; Region: COG3177 1114970016728 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 1114970016729 Fic/DOC family; Region: Fic; pfam02661 1114970016730 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1114970016731 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1114970016732 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1114970016733 substrate binding pocket [chemical binding]; other site 1114970016734 chain length determination region; other site 1114970016735 substrate-Mg2+ binding site; other site 1114970016736 catalytic residues [active] 1114970016737 aspartate-rich region 1; other site 1114970016738 active site lid residues [active] 1114970016739 aspartate-rich region 2; other site 1114970016740 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1114970016741 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1114970016742 TPP-binding site; other site 1114970016743 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1114970016744 PYR/PP interface [polypeptide binding]; other site 1114970016745 dimer interface [polypeptide binding]; other site 1114970016746 TPP binding site [chemical binding]; other site 1114970016747 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1114970016748 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1114970016749 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970016750 N-terminal plug; other site 1114970016751 ligand-binding site [chemical binding]; other site 1114970016752 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1114970016753 cobalamin binding residues [chemical binding]; other site 1114970016754 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 1114970016755 putative BtuC binding residues; other site 1114970016756 dimer interface [polypeptide binding]; other site 1114970016757 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1114970016758 dimerization interface [polypeptide binding]; other site 1114970016759 active site 1114970016760 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970016761 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1114970016762 substrate binding pocket [chemical binding]; other site 1114970016763 membrane-bound complex binding site; other site 1114970016764 hinge residues; other site 1114970016765 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1114970016766 tetramer interfaces [polypeptide binding]; other site 1114970016767 binuclear metal-binding site [ion binding]; other site 1114970016768 thiamine monophosphate kinase; Provisional; Region: PRK05731 1114970016769 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1114970016770 ATP binding site [chemical binding]; other site 1114970016771 dimerization interface [polypeptide binding]; other site 1114970016772 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1114970016773 putative RNA binding site [nucleotide binding]; other site 1114970016774 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1114970016775 homopentamer interface [polypeptide binding]; other site 1114970016776 active site 1114970016777 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 1114970016778 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1114970016779 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 1114970016780 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1114970016781 Lumazine binding domain; Region: Lum_binding; pfam00677 1114970016782 Lumazine binding domain; Region: Lum_binding; pfam00677 1114970016783 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 1114970016784 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1114970016785 catalytic motif [active] 1114970016786 Zn binding site [ion binding]; other site 1114970016787 RibD C-terminal domain; Region: RibD_C; cl17279 1114970016788 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1114970016789 ATP cone domain; Region: ATP-cone; pfam03477 1114970016790 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 1114970016791 Predicted methyltransferase [General function prediction only]; Region: COG3897 1114970016792 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1114970016793 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1114970016794 Protein of unknown function (DUF2796); Region: DUF2796; pfam10986 1114970016795 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1114970016796 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1114970016797 Walker A/P-loop; other site 1114970016798 ATP binding site [chemical binding]; other site 1114970016799 Q-loop/lid; other site 1114970016800 ABC transporter signature motif; other site 1114970016801 Walker B; other site 1114970016802 D-loop; other site 1114970016803 H-loop/switch region; other site 1114970016804 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1114970016805 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1114970016806 FtsX-like permease family; Region: FtsX; pfam02687 1114970016807 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 1114970016808 OmpW family; Region: OmpW; cl17427 1114970016809 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970016810 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1114970016811 NAD(P) binding site [chemical binding]; other site 1114970016812 active site 1114970016813 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1114970016814 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970016815 NAD(P) binding site [chemical binding]; other site 1114970016816 active site 1114970016817 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 1114970016818 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114970016819 ATP binding site [chemical binding]; other site 1114970016820 putative Mg++ binding site [ion binding]; other site 1114970016821 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114970016822 nucleotide binding region [chemical binding]; other site 1114970016823 ATP-binding site [chemical binding]; other site 1114970016824 DEAD/H associated; Region: DEAD_assoc; pfam08494 1114970016825 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1114970016826 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1114970016827 Protein of unknown function DUF72; Region: DUF72; pfam01904 1114970016828 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 1114970016829 putative catalytic site [active] 1114970016830 putative metal binding site [ion binding]; other site 1114970016831 putative phosphate binding site [ion binding]; other site 1114970016832 cardiolipin synthase 2; Provisional; Region: PRK11263 1114970016833 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1114970016834 putative active site [active] 1114970016835 catalytic site [active] 1114970016836 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1114970016837 putative active site [active] 1114970016838 catalytic site [active] 1114970016839 Predicted integral membrane protein [Function unknown]; Region: COG0392 1114970016840 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1114970016841 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 1114970016842 Protein of unknown function (DUF3182); Region: DUF3182; pfam11379 1114970016843 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1114970016844 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 1114970016845 conserved cys residue [active] 1114970016846 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970016847 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1114970016848 Isochorismatase family; Region: Isochorismatase; pfam00857 1114970016849 catalytic triad [active] 1114970016850 conserved cis-peptide bond; other site 1114970016851 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1114970016852 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114970016853 non-specific DNA binding site [nucleotide binding]; other site 1114970016854 salt bridge; other site 1114970016855 sequence-specific DNA binding site [nucleotide binding]; other site 1114970016856 Predicted ATPase [General function prediction only]; Region: COG3899 1114970016857 AAA ATPase domain; Region: AAA_16; pfam13191 1114970016858 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1114970016859 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114970016860 TPR motif; other site 1114970016861 binding surface 1114970016862 TPR repeat; Region: TPR_11; pfam13414 1114970016863 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1114970016864 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1114970016865 dimer interface [polypeptide binding]; other site 1114970016866 ssDNA binding site [nucleotide binding]; other site 1114970016867 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1114970016868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970016869 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970016870 putative substrate translocation pore; other site 1114970016871 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1114970016872 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1114970016873 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1114970016874 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1114970016875 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1114970016876 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1114970016877 heme binding site [chemical binding]; other site 1114970016878 ferroxidase pore; other site 1114970016879 ferroxidase diiron center [ion binding]; other site 1114970016880 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1114970016881 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1114970016882 tetramer interface [polypeptide binding]; other site 1114970016883 heme binding pocket [chemical binding]; other site 1114970016884 NADPH binding site [chemical binding]; other site 1114970016885 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1114970016886 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1114970016887 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1114970016888 alphaNTD homodimer interface [polypeptide binding]; other site 1114970016889 alphaNTD - beta interaction site [polypeptide binding]; other site 1114970016890 alphaNTD - beta' interaction site [polypeptide binding]; other site 1114970016891 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1114970016892 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1114970016893 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1114970016894 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1114970016895 RNA binding surface [nucleotide binding]; other site 1114970016896 30S ribosomal protein S11; Validated; Region: PRK05309 1114970016897 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1114970016898 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1114970016899 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 1114970016900 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1114970016901 SecY translocase; Region: SecY; pfam00344 1114970016902 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1114970016903 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1114970016904 23S rRNA binding site [nucleotide binding]; other site 1114970016905 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1114970016906 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1114970016907 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1114970016908 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1114970016909 5S rRNA interface [nucleotide binding]; other site 1114970016910 23S rRNA interface [nucleotide binding]; other site 1114970016911 L5 interface [polypeptide binding]; other site 1114970016912 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1114970016913 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1114970016914 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1114970016915 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1114970016916 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1114970016917 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1114970016918 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1114970016919 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1114970016920 RNA binding site [nucleotide binding]; other site 1114970016921 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1114970016922 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1114970016923 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1114970016924 23S rRNA interface [nucleotide binding]; other site 1114970016925 putative translocon interaction site; other site 1114970016926 signal recognition particle (SRP54) interaction site; other site 1114970016927 L23 interface [polypeptide binding]; other site 1114970016928 trigger factor interaction site; other site 1114970016929 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1114970016930 23S rRNA interface [nucleotide binding]; other site 1114970016931 5S rRNA interface [nucleotide binding]; other site 1114970016932 putative antibiotic binding site [chemical binding]; other site 1114970016933 L25 interface [polypeptide binding]; other site 1114970016934 L27 interface [polypeptide binding]; other site 1114970016935 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1114970016936 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1114970016937 G-X-X-G motif; other site 1114970016938 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1114970016939 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1114970016940 putative translocon binding site; other site 1114970016941 protein-rRNA interface [nucleotide binding]; other site 1114970016942 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1114970016943 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1114970016944 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1114970016945 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1114970016946 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1114970016947 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1114970016948 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1114970016949 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1114970016950 elongation factor Tu; Reviewed; Region: PRK00049 1114970016951 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1114970016952 G1 box; other site 1114970016953 GEF interaction site [polypeptide binding]; other site 1114970016954 GTP/Mg2+ binding site [chemical binding]; other site 1114970016955 Switch I region; other site 1114970016956 G2 box; other site 1114970016957 G3 box; other site 1114970016958 Switch II region; other site 1114970016959 G4 box; other site 1114970016960 G5 box; other site 1114970016961 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1114970016962 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1114970016963 Antibiotic Binding Site [chemical binding]; other site 1114970016964 elongation factor G; Reviewed; Region: PRK00007 1114970016965 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1114970016966 G1 box; other site 1114970016967 putative GEF interaction site [polypeptide binding]; other site 1114970016968 GTP/Mg2+ binding site [chemical binding]; other site 1114970016969 Switch I region; other site 1114970016970 G2 box; other site 1114970016971 G3 box; other site 1114970016972 Switch II region; other site 1114970016973 G4 box; other site 1114970016974 G5 box; other site 1114970016975 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1114970016976 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1114970016977 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1114970016978 30S ribosomal protein S7; Validated; Region: PRK05302 1114970016979 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1114970016980 S17 interaction site [polypeptide binding]; other site 1114970016981 S8 interaction site; other site 1114970016982 16S rRNA interaction site [nucleotide binding]; other site 1114970016983 streptomycin interaction site [chemical binding]; other site 1114970016984 23S rRNA interaction site [nucleotide binding]; other site 1114970016985 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1114970016986 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1114970016987 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1114970016988 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1114970016989 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1114970016990 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1114970016991 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1114970016992 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1114970016993 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1114970016994 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1114970016995 DNA binding site [nucleotide binding] 1114970016996 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1114970016997 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1114970016998 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1114970016999 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1114970017000 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1114970017001 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1114970017002 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1114970017003 RPB3 interaction site [polypeptide binding]; other site 1114970017004 RPB1 interaction site [polypeptide binding]; other site 1114970017005 RPB11 interaction site [polypeptide binding]; other site 1114970017006 RPB10 interaction site [polypeptide binding]; other site 1114970017007 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1114970017008 peripheral dimer interface [polypeptide binding]; other site 1114970017009 core dimer interface [polypeptide binding]; other site 1114970017010 L10 interface [polypeptide binding]; other site 1114970017011 L11 interface [polypeptide binding]; other site 1114970017012 putative EF-Tu interaction site [polypeptide binding]; other site 1114970017013 putative EF-G interaction site [polypeptide binding]; other site 1114970017014 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1114970017015 23S rRNA interface [nucleotide binding]; other site 1114970017016 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1114970017017 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1114970017018 mRNA/rRNA interface [nucleotide binding]; other site 1114970017019 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1114970017020 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1114970017021 23S rRNA interface [nucleotide binding]; other site 1114970017022 L7/L12 interface [polypeptide binding]; other site 1114970017023 putative thiostrepton binding site; other site 1114970017024 L25 interface [polypeptide binding]; other site 1114970017025 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 1114970017026 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1114970017027 putative homodimer interface [polypeptide binding]; other site 1114970017028 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1114970017029 heterodimer interface [polypeptide binding]; other site 1114970017030 homodimer interface [polypeptide binding]; other site 1114970017031 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1114970017032 elongation factor Tu; Reviewed; Region: PRK00049 1114970017033 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1114970017034 G1 box; other site 1114970017035 GEF interaction site [polypeptide binding]; other site 1114970017036 GTP/Mg2+ binding site [chemical binding]; other site 1114970017037 Switch I region; other site 1114970017038 G2 box; other site 1114970017039 G3 box; other site 1114970017040 Switch II region; other site 1114970017041 G4 box; other site 1114970017042 G5 box; other site 1114970017043 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1114970017044 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1114970017045 Antibiotic Binding Site [chemical binding]; other site 1114970017046 Type III pantothenate kinase; Region: Pan_kinase; cl17198 1114970017047 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1114970017048 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1114970017049 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1114970017050 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1114970017051 active site 1114970017052 HIGH motif; other site 1114970017053 dimer interface [polypeptide binding]; other site 1114970017054 KMSKS motif; other site 1114970017055 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 1114970017056 putative peptidase; Provisional; Region: PRK11649 1114970017057 Peptidase family M23; Region: Peptidase_M23; pfam01551 1114970017058 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1114970017059 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1114970017060 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1114970017061 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1114970017062 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 1114970017063 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1114970017064 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1114970017065 FMN binding site [chemical binding]; other site 1114970017066 substrate binding site [chemical binding]; other site 1114970017067 putative catalytic residue [active] 1114970017068 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1114970017069 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1114970017070 classical (c) SDRs; Region: SDR_c; cd05233 1114970017071 NAD(P) binding site [chemical binding]; other site 1114970017072 active site 1114970017073 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1114970017074 nucleotide binding site/active site [active] 1114970017075 HIT family signature motif; other site 1114970017076 catalytic residue [active] 1114970017077 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 1114970017078 diiron binding motif [ion binding]; other site 1114970017079 OsmC-like protein; Region: OsmC; cl00767 1114970017080 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 1114970017081 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1114970017082 ligand binding site [chemical binding]; other site 1114970017083 flexible hinge region; other site 1114970017084 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1114970017085 putative switch regulator; other site 1114970017086 non-specific DNA interactions [nucleotide binding]; other site 1114970017087 DNA binding site [nucleotide binding] 1114970017088 sequence specific DNA binding site [nucleotide binding]; other site 1114970017089 putative cAMP binding site [chemical binding]; other site 1114970017090 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1114970017091 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1114970017092 active site 1114970017093 ribulose/triose binding site [chemical binding]; other site 1114970017094 phosphate binding site [ion binding]; other site 1114970017095 substrate (anthranilate) binding pocket [chemical binding]; other site 1114970017096 product (indole) binding pocket [chemical binding]; other site 1114970017097 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1114970017098 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1114970017099 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1114970017100 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1114970017101 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1114970017102 glutamine binding [chemical binding]; other site 1114970017103 catalytic triad [active] 1114970017104 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 1114970017105 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 1114970017106 active site 1114970017107 catalytic triad [active] 1114970017108 oxyanion hole [active] 1114970017109 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1114970017110 anthranilate synthase component I; Provisional; Region: PRK13565 1114970017111 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1114970017112 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1114970017113 phosphoglycolate phosphatase; Provisional; Region: PRK13223 1114970017114 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1114970017115 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114970017116 motif II; other site 1114970017117 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1114970017118 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1114970017119 substrate binding site [chemical binding]; other site 1114970017120 hexamer interface [polypeptide binding]; other site 1114970017121 metal binding site [ion binding]; metal-binding site 1114970017122 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1114970017123 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1114970017124 active site 1114970017125 NAD binding site [chemical binding]; other site 1114970017126 metal binding site [ion binding]; metal-binding site 1114970017127 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1114970017128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970017129 dimer interface [polypeptide binding]; other site 1114970017130 conserved gate region; other site 1114970017131 putative PBP binding loops; other site 1114970017132 ABC-ATPase subunit interface; other site 1114970017133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970017134 dimer interface [polypeptide binding]; other site 1114970017135 conserved gate region; other site 1114970017136 putative PBP binding loops; other site 1114970017137 ABC-ATPase subunit interface; other site 1114970017138 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1114970017139 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1114970017140 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1114970017141 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1114970017142 Walker A/P-loop; other site 1114970017143 ATP binding site [chemical binding]; other site 1114970017144 Q-loop/lid; other site 1114970017145 ABC transporter signature motif; other site 1114970017146 Walker B; other site 1114970017147 D-loop; other site 1114970017148 H-loop/switch region; other site 1114970017149 TOBE domain; Region: TOBE_2; pfam08402 1114970017150 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114970017151 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970017152 active site 1114970017153 phosphorylation site [posttranslational modification] 1114970017154 intermolecular recognition site; other site 1114970017155 dimerization interface [polypeptide binding]; other site 1114970017156 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114970017157 DNA binding residues [nucleotide binding] 1114970017158 dimerization interface [polypeptide binding]; other site 1114970017159 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970017160 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970017161 substrate binding pocket [chemical binding]; other site 1114970017162 membrane-bound complex binding site; other site 1114970017163 hinge residues; other site 1114970017164 PAS domain; Region: PAS_9; pfam13426 1114970017165 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970017166 putative active site [active] 1114970017167 heme pocket [chemical binding]; other site 1114970017168 PAS fold; Region: PAS_3; pfam08447 1114970017169 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1114970017170 Histidine kinase; Region: HisKA_3; pfam07730 1114970017171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970017172 ATP binding site [chemical binding]; other site 1114970017173 Mg2+ binding site [ion binding]; other site 1114970017174 G-X-G motif; other site 1114970017175 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 1114970017176 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114970017177 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 1114970017178 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1114970017179 putative metal binding site [ion binding]; other site 1114970017180 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1114970017181 HSP70 interaction site [polypeptide binding]; other site 1114970017182 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1114970017183 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 1114970017184 Substrate binding site; other site 1114970017185 metal-binding site 1114970017186 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 1114970017187 Phosphotransferase enzyme family; Region: APH; pfam01636 1114970017188 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 1114970017189 OstA-like protein; Region: OstA; cl00844 1114970017190 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1114970017191 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1114970017192 SurA N-terminal domain; Region: SurA_N; pfam09312 1114970017193 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1114970017194 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1114970017195 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1114970017196 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1114970017197 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1114970017198 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1114970017199 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1114970017200 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 1114970017201 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1114970017202 active site 1114970017203 metal binding site [ion binding]; metal-binding site 1114970017204 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1114970017205 active site residue [active] 1114970017206 PrkA family serine protein kinase; Provisional; Region: PRK15455 1114970017207 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1114970017208 hypothetical protein; Provisional; Region: PRK05325 1114970017209 SpoVR family protein; Provisional; Region: PRK11767 1114970017210 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1114970017211 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1114970017212 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1114970017213 active site 1114970017214 NTP binding site [chemical binding]; other site 1114970017215 metal binding triad [ion binding]; metal-binding site 1114970017216 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1114970017217 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1114970017218 Zn2+ binding site [ion binding]; other site 1114970017219 Mg2+ binding site [ion binding]; other site 1114970017220 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1114970017221 catalytic center binding site [active] 1114970017222 ATP binding site [chemical binding]; other site 1114970017223 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1114970017224 homooctamer interface [polypeptide binding]; other site 1114970017225 active site 1114970017226 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1114970017227 UGMP family protein; Validated; Region: PRK09604 1114970017228 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1114970017229 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1114970017230 DNA primase, catalytic core; Region: dnaG; TIGR01391 1114970017231 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1114970017232 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1114970017233 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1114970017234 active site 1114970017235 metal binding site [ion binding]; metal-binding site 1114970017236 interdomain interaction site; other site 1114970017237 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1114970017238 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 1114970017239 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1114970017240 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1114970017241 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1114970017242 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1114970017243 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970017244 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1114970017245 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114970017246 DNA binding residues [nucleotide binding] 1114970017247 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970017248 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970017249 substrate binding pocket [chemical binding]; other site 1114970017250 membrane-bound complex binding site; other site 1114970017251 hinge residues; other site 1114970017252 PAS domain S-box; Region: sensory_box; TIGR00229 1114970017253 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970017254 putative active site [active] 1114970017255 heme pocket [chemical binding]; other site 1114970017256 PAS domain S-box; Region: sensory_box; TIGR00229 1114970017257 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970017258 putative active site [active] 1114970017259 heme pocket [chemical binding]; other site 1114970017260 PAS domain S-box; Region: sensory_box; TIGR00229 1114970017261 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970017262 putative active site [active] 1114970017263 heme pocket [chemical binding]; other site 1114970017264 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970017265 PAS domain; Region: PAS_9; pfam13426 1114970017266 putative active site [active] 1114970017267 heme pocket [chemical binding]; other site 1114970017268 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114970017269 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970017270 metal binding site [ion binding]; metal-binding site 1114970017271 active site 1114970017272 I-site; other site 1114970017273 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970017274 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1114970017275 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970017276 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1114970017277 dimerization interface [polypeptide binding]; other site 1114970017278 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 1114970017279 heterodimer interface [polypeptide binding]; other site 1114970017280 multimer interface [polypeptide binding]; other site 1114970017281 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 1114970017282 active site 1114970017283 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 1114970017284 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 1114970017285 heterodimer interface [polypeptide binding]; other site 1114970017286 active site 1114970017287 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1114970017288 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1114970017289 putative DNA binding site [nucleotide binding]; other site 1114970017290 putative Zn2+ binding site [ion binding]; other site 1114970017291 AsnC family; Region: AsnC_trans_reg; pfam01037 1114970017292 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114970017293 non-specific DNA binding site [nucleotide binding]; other site 1114970017294 salt bridge; other site 1114970017295 sequence-specific DNA binding site [nucleotide binding]; other site 1114970017296 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 1114970017297 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1114970017298 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1114970017299 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 1114970017300 putative active site [active] 1114970017301 catalytic triad [active] 1114970017302 putative dimer interface [polypeptide binding]; other site 1114970017303 coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110 1114970017304 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1114970017305 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1114970017306 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 1114970017307 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 1114970017308 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 1114970017309 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 1114970017310 pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079 1114970017311 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 1114970017312 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114970017313 FeS/SAM binding site; other site 1114970017314 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1114970017315 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1114970017316 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1114970017317 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 1114970017318 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1114970017319 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1114970017320 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1114970017321 active site 1114970017322 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1114970017323 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1114970017324 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1114970017325 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 1114970017326 FAD binding site [chemical binding]; other site 1114970017327 substrate binding site [chemical binding]; other site 1114970017328 catalytic residues [active] 1114970017329 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1114970017330 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114970017331 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970017332 metal binding site [ion binding]; metal-binding site 1114970017333 active site 1114970017334 I-site; other site 1114970017335 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1114970017336 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1114970017337 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1114970017338 active site 1114970017339 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1114970017340 AAA domain; Region: AAA_26; pfam13500 1114970017341 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1114970017342 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1114970017343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970017344 S-adenosylmethionine binding site [chemical binding]; other site 1114970017345 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 1114970017346 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1114970017347 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1114970017348 substrate-cofactor binding pocket; other site 1114970017349 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970017350 catalytic residue [active] 1114970017351 biotin synthase; Provisional; Region: PRK15108 1114970017352 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114970017353 FeS/SAM binding site; other site 1114970017354 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1114970017355 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1114970017356 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114970017357 active site 1114970017358 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 1114970017359 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1114970017360 TOBE domain; Region: TOBE; cl01440 1114970017361 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 1114970017362 serine/threonine protein kinase; Provisional; Region: PRK11768 1114970017363 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1114970017364 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1114970017365 EamA-like transporter family; Region: EamA; pfam00892 1114970017366 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 1114970017367 ACT domain; Region: ACT_6; pfam13740 1114970017368 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 1114970017369 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 1114970017370 active site 1114970017371 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970017372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970017373 active site 1114970017374 phosphorylation site [posttranslational modification] 1114970017375 intermolecular recognition site; other site 1114970017376 dimerization interface [polypeptide binding]; other site 1114970017377 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 1114970017378 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1114970017379 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 1114970017380 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 1114970017381 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1114970017382 metal binding triad; other site 1114970017383 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1114970017384 active site 1114970017385 catalytic site [active] 1114970017386 substrate binding site [chemical binding]; other site 1114970017387 RNA polymerase sigma factor; Reviewed; Region: PRK12523 1114970017388 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970017389 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114970017390 DNA binding residues [nucleotide binding] 1114970017391 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1114970017392 FecR protein; Region: FecR; pfam04773 1114970017393 Secretin and TonB N terminus short domain; Region: STN; smart00965 1114970017394 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1114970017395 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1114970017396 N-terminal plug; other site 1114970017397 ligand-binding site [chemical binding]; other site 1114970017398 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1114970017399 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1114970017400 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1114970017401 putative glutathione S-transferase; Provisional; Region: PRK10357 1114970017402 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 1114970017403 putative C-terminal domain interface [polypeptide binding]; other site 1114970017404 putative GSH binding site (G-site) [chemical binding]; other site 1114970017405 putative dimer interface [polypeptide binding]; other site 1114970017406 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1114970017407 dimer interface [polypeptide binding]; other site 1114970017408 N-terminal domain interface [polypeptide binding]; other site 1114970017409 putative substrate binding pocket (H-site) [chemical binding]; other site 1114970017410 inner membrane protein; Provisional; Region: PRK11715 1114970017411 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1114970017412 sensory histidine kinase CreC; Provisional; Region: PRK11100 1114970017413 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1114970017414 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114970017415 dimer interface [polypeptide binding]; other site 1114970017416 phosphorylation site [posttranslational modification] 1114970017417 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970017418 ATP binding site [chemical binding]; other site 1114970017419 Mg2+ binding site [ion binding]; other site 1114970017420 G-X-G motif; other site 1114970017421 DNA-binding response regulator CreB; Provisional; Region: PRK11083 1114970017422 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970017423 active site 1114970017424 phosphorylation site [posttranslational modification] 1114970017425 intermolecular recognition site; other site 1114970017426 dimerization interface [polypeptide binding]; other site 1114970017427 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114970017428 DNA binding site [nucleotide binding] 1114970017429 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1114970017430 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 1114970017431 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1114970017432 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1114970017433 putative acyl-acceptor binding pocket; other site 1114970017434 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1114970017435 Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075 1114970017436 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1114970017437 DNA-binding site [nucleotide binding]; DNA binding site 1114970017438 RNA-binding motif; other site 1114970017439 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1114970017440 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 1114970017441 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 1114970017442 NAD binding site [chemical binding]; other site 1114970017443 catalytic Zn binding site [ion binding]; other site 1114970017444 structural Zn binding site [ion binding]; other site 1114970017445 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 1114970017446 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1114970017447 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1114970017448 putative active site [active] 1114970017449 putative substrate binding site [chemical binding]; other site 1114970017450 putative cosubstrate binding site; other site 1114970017451 catalytic site [active] 1114970017452 Sarcosine oxidase, gamma subunit family; Region: SoxG; pfam04268 1114970017453 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 1114970017454 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1114970017455 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1114970017456 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 1114970017457 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 1114970017458 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1114970017459 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1114970017460 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1114970017461 dimer interface [polypeptide binding]; other site 1114970017462 active site 1114970017463 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1114970017464 folate binding site [chemical binding]; other site 1114970017465 TraX protein; Region: TraX; pfam05857 1114970017466 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1114970017467 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1114970017468 tetramer interface [polypeptide binding]; other site 1114970017469 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970017470 catalytic residue [active] 1114970017471 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1114970017472 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1114970017473 FAD binding pocket [chemical binding]; other site 1114970017474 FAD binding motif [chemical binding]; other site 1114970017475 phosphate binding motif [ion binding]; other site 1114970017476 beta-alpha-beta structure motif; other site 1114970017477 NAD binding pocket [chemical binding]; other site 1114970017478 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1114970017479 catalytic loop [active] 1114970017480 iron binding site [ion binding]; other site 1114970017481 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1114970017482 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1114970017483 [2Fe-2S] cluster binding site [ion binding]; other site 1114970017484 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 1114970017485 putative alpha subunit interface [polypeptide binding]; other site 1114970017486 putative active site [active] 1114970017487 putative substrate binding site [chemical binding]; other site 1114970017488 Fe binding site [ion binding]; other site 1114970017489 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 1114970017490 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1114970017491 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1114970017492 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1114970017493 Ligand Binding Site [chemical binding]; other site 1114970017494 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1114970017495 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1114970017496 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1114970017497 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 1114970017498 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1114970017499 Cysteine-rich domain; Region: CCG; pfam02754 1114970017500 Cysteine-rich domain; Region: CCG; pfam02754 1114970017501 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 1114970017502 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 1114970017503 putative active site [active] 1114970017504 putative FMN binding site [chemical binding]; other site 1114970017505 putative substrate binding site [chemical binding]; other site 1114970017506 putative catalytic residue [active] 1114970017507 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1114970017508 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 1114970017509 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1114970017510 Membrane dipeptidase (Peptidase family M19); Region: Peptidase_M19; pfam01244 1114970017511 active site 1114970017512 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1114970017513 Protein of unknown function (DUF3010); Region: DUF3010; pfam11215 1114970017514 Archaeal ATPase; Region: Arch_ATPase; pfam01637 1114970017515 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1114970017516 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1114970017517 conserved cys residue [active] 1114970017518 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1114970017519 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 1114970017520 Uncharacterized conserved protein [Function unknown]; Region: COG3246 1114970017521 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 1114970017522 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1114970017523 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1114970017524 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1114970017525 active site 1114970017526 Protein of unknown function (DUF971); Region: DUF971; cl01414 1114970017527 gamma-butyrobetaine hydroxylase; Region: carnitine_bodg; TIGR02409 1114970017528 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 1114970017529 substrate binding pocket [chemical binding]; other site 1114970017530 active site 1114970017531 iron coordination sites [ion binding]; other site 1114970017532 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1114970017533 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1114970017534 conserved cys residue [active] 1114970017535 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970017536 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1114970017537 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1114970017538 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1114970017539 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 1114970017540 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1114970017541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970017542 dimer interface [polypeptide binding]; other site 1114970017543 conserved gate region; other site 1114970017544 putative PBP binding loops; other site 1114970017545 ABC-ATPase subunit interface; other site 1114970017546 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 1114970017547 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114970017548 Walker A/P-loop; other site 1114970017549 ATP binding site [chemical binding]; other site 1114970017550 Q-loop/lid; other site 1114970017551 ABC transporter signature motif; other site 1114970017552 Walker B; other site 1114970017553 D-loop; other site 1114970017554 H-loop/switch region; other site 1114970017555 transcriptional regulator BetI; Validated; Region: PRK00767 1114970017556 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114970017557 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1114970017558 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 1114970017559 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 1114970017560 tetrameric interface [polypeptide binding]; other site 1114970017561 NAD binding site [chemical binding]; other site 1114970017562 catalytic residues [active] 1114970017563 choline dehydrogenase; Validated; Region: PRK02106 1114970017564 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1114970017565 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1114970017566 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1114970017567 putative transporter; Provisional; Region: PRK10504 1114970017568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970017569 putative substrate translocation pore; other site 1114970017570 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1114970017571 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1114970017572 ATP binding site [chemical binding]; other site 1114970017573 Mg++ binding site [ion binding]; other site 1114970017574 motif III; other site 1114970017575 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114970017576 nucleotide binding region [chemical binding]; other site 1114970017577 ATP-binding site [chemical binding]; other site 1114970017578 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 1114970017579 putative RNA binding site [nucleotide binding]; other site 1114970017580 HI0933-like protein; Region: HI0933_like; pfam03486 1114970017581 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1114970017582 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 1114970017583 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1114970017584 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1114970017585 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970017586 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970017587 substrate binding pocket [chemical binding]; other site 1114970017588 membrane-bound complex binding site; other site 1114970017589 hinge residues; other site 1114970017590 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1114970017591 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970017592 Coenzyme A binding pocket [chemical binding]; other site 1114970017593 Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; pfam09904 1114970017594 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 1114970017595 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970017596 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970017597 active site 1114970017598 phosphorylation site [posttranslational modification] 1114970017599 intermolecular recognition site; other site 1114970017600 dimerization interface [polypeptide binding]; other site 1114970017601 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970017602 PAS domain; Region: PAS_9; pfam13426 1114970017603 putative active site [active] 1114970017604 heme pocket [chemical binding]; other site 1114970017605 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114970017606 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970017607 metal binding site [ion binding]; metal-binding site 1114970017608 active site 1114970017609 I-site; other site 1114970017610 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970017611 Alginate lyase; Region: Alginate_lyase2; pfam08787 1114970017612 Alginate lyase; Region: Alginate_lyase2; pfam08787 1114970017613 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1114970017614 intersubunit interface [polypeptide binding]; other site 1114970017615 active site 1114970017616 zinc binding site [ion binding]; other site 1114970017617 Na+ binding site [ion binding]; other site 1114970017618 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1114970017619 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 1114970017620 Phosphoglycerate kinase; Region: PGK; pfam00162 1114970017621 substrate binding site [chemical binding]; other site 1114970017622 hinge regions; other site 1114970017623 ADP binding site [chemical binding]; other site 1114970017624 catalytic site [active] 1114970017625 erythrose-4-phosphate dehydrogenase; Region: E4PD_g-proteo; TIGR01532 1114970017626 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1114970017627 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1114970017628 transketolase; Reviewed; Region: PRK12753 1114970017629 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1114970017630 TPP-binding site [chemical binding]; other site 1114970017631 dimer interface [polypeptide binding]; other site 1114970017632 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1114970017633 PYR/PP interface [polypeptide binding]; other site 1114970017634 dimer interface [polypeptide binding]; other site 1114970017635 TPP binding site [chemical binding]; other site 1114970017636 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1114970017637 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114970017638 putative DNA binding site [nucleotide binding]; other site 1114970017639 putative Zn2+ binding site [ion binding]; other site 1114970017640 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1114970017641 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970017642 S-adenosylmethionine binding site [chemical binding]; other site 1114970017643 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1114970017644 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1114970017645 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1114970017646 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1114970017647 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1114970017648 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 1114970017649 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 1114970017650 nucleotide binding pocket [chemical binding]; other site 1114970017651 K-X-D-G motif; other site 1114970017652 catalytic site [active] 1114970017653 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1114970017654 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 1114970017655 Cytochrome C' Region: Cytochrom_C_2; pfam01322 1114970017656 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 1114970017657 MltA specific insert domain; Region: MltA; smart00925 1114970017658 3D domain; Region: 3D; pfam06725 1114970017659 Predicted membrane protein [Function unknown]; Region: COG3686 1114970017660 EamA-like transporter family; Region: EamA; pfam00892 1114970017661 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1114970017662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970017663 putative substrate translocation pore; other site 1114970017664 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1114970017665 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1114970017666 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1114970017667 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1114970017668 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1114970017669 homotetramer interface [polypeptide binding]; other site 1114970017670 ligand binding site [chemical binding]; other site 1114970017671 catalytic site [active] 1114970017672 NAD binding site [chemical binding]; other site 1114970017673 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1114970017674 FAD binding site [chemical binding]; other site 1114970017675 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970017676 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970017677 substrate binding pocket [chemical binding]; other site 1114970017678 membrane-bound complex binding site; other site 1114970017679 hinge residues; other site 1114970017680 helicase 45; Provisional; Region: PTZ00424 1114970017681 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1114970017682 ATP binding site [chemical binding]; other site 1114970017683 Mg++ binding site [ion binding]; other site 1114970017684 motif III; other site 1114970017685 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114970017686 nucleotide binding region [chemical binding]; other site 1114970017687 ATP-binding site [chemical binding]; other site 1114970017688 YceI-like domain; Region: YceI; cl01001 1114970017689 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1114970017690 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1114970017691 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1114970017692 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK07030 1114970017693 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114970017694 inhibitor-cofactor binding pocket; inhibition site 1114970017695 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970017696 catalytic residue [active] 1114970017697 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1114970017698 RNA methyltransferase, RsmE family; Region: TIGR00046 1114970017699 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1114970017700 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1114970017701 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970017702 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970017703 The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416 1114970017704 putative dimerization interface [polypeptide binding]; other site 1114970017705 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 1114970017706 Malonate transporter MadL subunit; Region: MadL; cl04273 1114970017707 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 1114970017708 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1114970017709 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 1114970017710 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 1114970017711 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 1114970017712 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 1114970017713 malonate decarboxylase subunit delta; Provisional; Region: PRK01220 1114970017714 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 1114970017715 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 1114970017716 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1114970017717 active site 1114970017718 NTP binding site [chemical binding]; other site 1114970017719 metal binding triad [ion binding]; metal-binding site 1114970017720 antibiotic binding site [chemical binding]; other site 1114970017721 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 1114970017722 Hpt domain; Region: Hpt; pfam01627 1114970017723 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1114970017724 putative binding surface; other site 1114970017725 active site 1114970017726 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1114970017727 putative binding surface; other site 1114970017728 active site 1114970017729 Hpt domain; Region: Hpt; pfam01627 1114970017730 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1114970017731 putative binding surface; other site 1114970017732 active site 1114970017733 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1114970017734 putative binding surface; other site 1114970017735 active site 1114970017736 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1114970017737 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1114970017738 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970017739 ATP binding site [chemical binding]; other site 1114970017740 Mg2+ binding site [ion binding]; other site 1114970017741 G-X-G motif; other site 1114970017742 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1114970017743 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970017744 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970017745 active site 1114970017746 phosphorylation site [posttranslational modification] 1114970017747 intermolecular recognition site; other site 1114970017748 dimerization interface [polypeptide binding]; other site 1114970017749 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1114970017750 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970017751 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970017752 dimer interface [polypeptide binding]; other site 1114970017753 putative CheW interface [polypeptide binding]; other site 1114970017754 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1114970017755 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970017756 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970017757 active site 1114970017758 phosphorylation site [posttranslational modification] 1114970017759 intermolecular recognition site; other site 1114970017760 dimerization interface [polypeptide binding]; other site 1114970017761 Response regulator receiver domain; Region: Response_reg; pfam00072 1114970017762 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970017763 active site 1114970017764 phosphorylation site [posttranslational modification] 1114970017765 intermolecular recognition site; other site 1114970017766 dimerization interface [polypeptide binding]; other site 1114970017767 glutathione synthetase; Provisional; Region: PRK05246 1114970017768 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1114970017769 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1114970017770 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1114970017771 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1114970017772 hypothetical protein; Validated; Region: PRK00228 1114970017773 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1114970017774 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1114970017775 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114970017776 active site 1114970017777 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1114970017778 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1114970017779 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1114970017780 dihydroorotase; Validated; Region: pyrC; PRK09357 1114970017781 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1114970017782 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1114970017783 active site 1114970017784 TM2 domain; Region: TM2; cl00984 1114970017785 TM2 domain; Region: TM2; cl00984 1114970017786 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1114970017787 NlpC/P60 family; Region: NLPC_P60; pfam00877 1114970017788 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1114970017789 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1114970017790 Walker A motif; other site 1114970017791 ATP binding site [chemical binding]; other site 1114970017792 Walker B motif; other site 1114970017793 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 1114970017794 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1114970017795 catalytic residue [active] 1114970017796 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1114970017797 pyrroline-5-carboxylate reductase; Region: PLN02688 1114970017798 YGGT family; Region: YGGT; pfam02325 1114970017799 YGGT family; Region: YGGT; pfam02325 1114970017800 hypothetical protein; Validated; Region: PRK05090 1114970017801 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1114970017802 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1114970017803 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1114970017804 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970017805 S-adenosylmethionine binding site [chemical binding]; other site 1114970017806 Domain of unknown function (DUF4426); Region: DUF4426; pfam14467 1114970017807 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1114970017808 active site 1114970017809 dimerization interface [polypeptide binding]; other site 1114970017810 HemN family oxidoreductase; Provisional; Region: PRK05660 1114970017811 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114970017812 FeS/SAM binding site; other site 1114970017813 HemN C-terminal domain; Region: HemN_C; pfam06969 1114970017814 Protein of unknown function (DUF3392); Region: DUF3392; pfam11872 1114970017815 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970017816 S-adenosylmethionine binding site [chemical binding]; other site 1114970017817 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1114970017818 ThiS interaction site; other site 1114970017819 putative active site [active] 1114970017820 tetramer interface [polypeptide binding]; other site 1114970017821 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1114970017822 thiS-thiF/thiG interaction site; other site 1114970017823 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1114970017824 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1114970017825 Transglycosylase; Region: Transgly; cl17702 1114970017826 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1114970017827 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1114970017828 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970017829 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114970017830 DNA binding residues [nucleotide binding] 1114970017831 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1114970017832 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1114970017833 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1114970017834 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114970017835 Walker A/P-loop; other site 1114970017836 ATP binding site [chemical binding]; other site 1114970017837 Q-loop/lid; other site 1114970017838 ABC transporter signature motif; other site 1114970017839 Walker B; other site 1114970017840 D-loop; other site 1114970017841 H-loop/switch region; other site 1114970017842 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1114970017843 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1114970017844 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1114970017845 P loop; other site 1114970017846 GTP binding site [chemical binding]; other site 1114970017847 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1114970017848 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1114970017849 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1114970017850 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1114970017851 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1114970017852 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1114970017853 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970017854 S-adenosylmethionine binding site [chemical binding]; other site 1114970017855 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 1114970017856 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1114970017857 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1114970017858 active site residue [active] 1114970017859 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1114970017860 active site residue [active] 1114970017861 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970017862 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114970017863 Bacterial transcriptional repressor; Region: TetR; pfam13972 1114970017864 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 1114970017865 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1114970017866 NAD(P) binding site [chemical binding]; other site 1114970017867 catalytic residues [active] 1114970017868 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1114970017869 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1114970017870 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1114970017871 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1114970017872 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1114970017873 active site 1114970017874 (T/H)XGH motif; other site 1114970017875 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1114970017876 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1114970017877 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1114970017878 DNA binding site [nucleotide binding] 1114970017879 catalytic residue [active] 1114970017880 H2TH interface [polypeptide binding]; other site 1114970017881 putative catalytic residues [active] 1114970017882 turnover-facilitating residue; other site 1114970017883 intercalation triad [nucleotide binding]; other site 1114970017884 8OG recognition residue [nucleotide binding]; other site 1114970017885 putative reading head residues; other site 1114970017886 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1114970017887 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1114970017888 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 1114970017889 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1114970017890 Zn2+ binding site [ion binding]; other site 1114970017891 Mg2+ binding site [ion binding]; other site 1114970017892 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1114970017893 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1114970017894 putative RNA binding site [nucleotide binding]; other site 1114970017895 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970017896 S-adenosylmethionine binding site [chemical binding]; other site 1114970017897 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1114970017898 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1114970017899 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1114970017900 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1114970017901 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1114970017902 folate binding site [chemical binding]; other site 1114970017903 NADP+ binding site [chemical binding]; other site 1114970017904 Protein of unknown function (DUF2868); Region: DUF2868; pfam11067 1114970017905 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1114970017906 G1 box; other site 1114970017907 GTP/Mg2+ binding site [chemical binding]; other site 1114970017908 G2 box; other site 1114970017909 Switch I region; other site 1114970017910 G3 box; other site 1114970017911 Switch II region; other site 1114970017912 G4 box; other site 1114970017913 Domain of unknown function (DUF3482); Region: DUF3482; pfam11981 1114970017914 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1114970017915 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 1114970017916 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 1114970017917 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 1114970017918 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1114970017919 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1114970017920 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1114970017921 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970017922 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1114970017923 Walker A motif; other site 1114970017924 ATP binding site [chemical binding]; other site 1114970017925 Walker B motif; other site 1114970017926 arginine finger; other site 1114970017927 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1114970017928 HrpZ; Region: Hairpins; pfam04877 1114970017929 Type III secretion needle MxiH like; Region: MxiH; cl09641 1114970017930 type III secretion apparatus lipoprotein, YscJ/HrcJ family; Region: III_secr_YscJ; TIGR02544 1114970017931 HrpE/YscL/FliH and V-type ATPase subunit E; Region: HrpE; pfam06188 1114970017932 HrpF protein; Region: HrpF; pfam06266 1114970017933 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 1114970017934 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1114970017935 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1114970017936 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1114970017937 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 1114970017938 type III secretion protein, YscU/HrpY family; Region: FlhB_rel_III; TIGR01404 1114970017939 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1114970017940 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 1114970017941 type III secretion protein, HrpO family; Region: fliQ_rel_III; TIGR01403 1114970017942 type III secretion system protein YscR; Provisional; Region: PRK12797 1114970017943 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 1114970017944 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1114970017945 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 1114970017946 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1114970017947 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1114970017948 Walker A motif; other site 1114970017949 ATP binding site [chemical binding]; other site 1114970017950 Walker B motif; other site 1114970017951 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 1114970017952 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 1114970017953 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 1114970017954 FHIPEP family; Region: FHIPEP; pfam00771 1114970017955 HrpJ-like domain; Region: HrpJ; cl15454 1114970017956 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1114970017957 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114970017958 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114970017959 DNA binding residues [nucleotide binding] 1114970017960 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1114970017961 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970017962 Coenzyme A binding pocket [chemical binding]; other site 1114970017963 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1114970017964 Cytochrome P450; Region: p450; cl12078 1114970017965 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1114970017966 Beta-lactamase; Region: Beta-lactamase; pfam00144 1114970017967 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 1114970017968 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1114970017969 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1114970017970 catalytic residue [active] 1114970017971 Tir chaperone protein (CesT) family; Region: CesT; cl08444 1114970017972 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 1114970017973 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1114970017974 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 1114970017975 active site 1114970017976 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1114970017977 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1114970017978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970017979 dimer interface [polypeptide binding]; other site 1114970017980 conserved gate region; other site 1114970017981 putative PBP binding loops; other site 1114970017982 ABC-ATPase subunit interface; other site 1114970017983 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1114970017984 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970017985 dimer interface [polypeptide binding]; other site 1114970017986 conserved gate region; other site 1114970017987 putative PBP binding loops; other site 1114970017988 ABC-ATPase subunit interface; other site 1114970017989 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 1114970017990 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114970017991 Walker A/P-loop; other site 1114970017992 ATP binding site [chemical binding]; other site 1114970017993 Q-loop/lid; other site 1114970017994 ABC transporter signature motif; other site 1114970017995 Walker B; other site 1114970017996 D-loop; other site 1114970017997 H-loop/switch region; other site 1114970017998 TOBE domain; Region: TOBE_2; pfam08402 1114970017999 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1114970018000 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1114970018001 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1114970018002 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1114970018003 putative aminotransferase; Validated; Region: PRK07480 1114970018004 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114970018005 inhibitor-cofactor binding pocket; inhibition site 1114970018006 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970018007 catalytic residue [active] 1114970018008 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1114970018009 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1114970018010 Peptidase C26; Region: Peptidase_C26; pfam07722 1114970018011 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1114970018012 catalytic triad [active] 1114970018013 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1114970018014 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1114970018015 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114970018016 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114970018017 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1114970018018 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 1114970018019 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1114970018020 Walker A/P-loop; other site 1114970018021 ATP binding site [chemical binding]; other site 1114970018022 Q-loop/lid; other site 1114970018023 ABC transporter signature motif; other site 1114970018024 Walker B; other site 1114970018025 D-loop; other site 1114970018026 H-loop/switch region; other site 1114970018027 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1114970018028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970018029 dimer interface [polypeptide binding]; other site 1114970018030 conserved gate region; other site 1114970018031 putative PBP binding loops; other site 1114970018032 ABC-ATPase subunit interface; other site 1114970018033 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1114970018034 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1114970018035 active site 1114970018036 dimer interface [polypeptide binding]; other site 1114970018037 non-prolyl cis peptide bond; other site 1114970018038 insertion regions; other site 1114970018039 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1114970018040 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970018041 substrate binding pocket [chemical binding]; other site 1114970018042 membrane-bound complex binding site; other site 1114970018043 hinge residues; other site 1114970018044 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 1114970018045 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1114970018046 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1114970018047 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 1114970018048 dimer interface [polypeptide binding]; other site 1114970018049 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1114970018050 catalytic triad [active] 1114970018051 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1114970018052 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970018053 putative substrate translocation pore; other site 1114970018054 prephenate dehydrogenase; Provisional; Region: PRK08655 1114970018055 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1114970018056 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1114970018057 glutamine binding [chemical binding]; other site 1114970018058 catalytic triad [active] 1114970018059 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1114970018060 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1114970018061 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1114970018062 hypothetical protein; Provisional; Region: PRK07505 1114970018063 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1114970018064 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114970018065 catalytic residue [active] 1114970018066 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1114970018067 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970018068 S-adenosylmethionine binding site [chemical binding]; other site 1114970018069 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1114970018070 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1114970018071 active site 1114970018072 NTP binding site [chemical binding]; other site 1114970018073 metal binding triad [ion binding]; metal-binding site 1114970018074 antibiotic binding site [chemical binding]; other site 1114970018075 Protein of unknown function DUF86; Region: DUF86; pfam01934 1114970018076 outer membrane porin, OprD family; Region: OprD; pfam03573 1114970018077 N-acetylglutamate synthase; Validated; Region: PRK05279 1114970018078 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1114970018079 putative feedback inhibition sensing region; other site 1114970018080 putative nucleotide binding site [chemical binding]; other site 1114970018081 putative substrate binding site [chemical binding]; other site 1114970018082 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970018083 Coenzyme A binding pocket [chemical binding]; other site 1114970018084 acetylornithine deacetylase; Provisional; Region: PRK05111 1114970018085 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1114970018086 metal binding site [ion binding]; metal-binding site 1114970018087 putative dimer interface [polypeptide binding]; other site 1114970018088 Uncharacterized conserved protein [Function unknown]; Region: COG3025 1114970018089 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 1114970018090 putative active site [active] 1114970018091 putative metal binding residues [ion binding]; other site 1114970018092 signature motif; other site 1114970018093 putative triphosphate binding site [ion binding]; other site 1114970018094 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1114970018095 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114970018096 putative DNA binding site [nucleotide binding]; other site 1114970018097 putative Zn2+ binding site [ion binding]; other site 1114970018098 AsnC family; Region: AsnC_trans_reg; pfam01037 1114970018099 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1114970018100 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1114970018101 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1114970018102 Walker A motif; other site 1114970018103 ATP binding site [chemical binding]; other site 1114970018104 Walker B motif; other site 1114970018105 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1114970018106 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1114970018107 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1114970018108 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 1114970018109 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1114970018110 lipoyl attachment site [posttranslational modification]; other site 1114970018111 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1114970018112 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1114970018113 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1114970018114 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970018115 dimer interface [polypeptide binding]; other site 1114970018116 conserved gate region; other site 1114970018117 putative PBP binding loops; other site 1114970018118 ABC-ATPase subunit interface; other site 1114970018119 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1114970018120 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1114970018121 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK05714 1114970018122 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1114970018123 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 1114970018124 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 1114970018125 proline aminopeptidase P II; Provisional; Region: PRK10879 1114970018126 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1114970018127 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1114970018128 active site 1114970018129 hypothetical protein; Reviewed; Region: PRK02166 1114970018130 TIGR02449 family protein; Region: TIGR02449 1114970018131 Cell division protein ZapA; Region: ZapA; pfam05164 1114970018132 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 1114970018133 EVE domain; Region: EVE; cl00728 1114970018134 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1114970018135 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1114970018136 HlyD family secretion protein; Region: HlyD_3; pfam13437 1114970018137 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1114970018138 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1114970018139 Walker A/P-loop; other site 1114970018140 ATP binding site [chemical binding]; other site 1114970018141 Q-loop/lid; other site 1114970018142 ABC transporter signature motif; other site 1114970018143 Walker B; other site 1114970018144 D-loop; other site 1114970018145 H-loop/switch region; other site 1114970018146 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1114970018147 Walker A/P-loop; other site 1114970018148 ATP binding site [chemical binding]; other site 1114970018149 Q-loop/lid; other site 1114970018150 ABC transporter signature motif; other site 1114970018151 Walker B; other site 1114970018152 D-loop; other site 1114970018153 H-loop/switch region; other site 1114970018154 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1114970018155 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1114970018156 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1114970018157 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1114970018158 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1114970018159 flagellar basal body-associated protein FliL-like protein; Validated; Region: PRK05697 1114970018160 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1114970018161 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1114970018162 NAD(P) binding site [chemical binding]; other site 1114970018163 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1114970018164 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1114970018165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970018166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970018167 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 1114970018168 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1114970018169 putative active site pocket [active] 1114970018170 dimerization interface [polypeptide binding]; other site 1114970018171 putative catalytic residue [active] 1114970018172 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1114970018173 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1114970018174 catalytic loop [active] 1114970018175 iron binding site [ion binding]; other site 1114970018176 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1114970018177 FAD binding pocket [chemical binding]; other site 1114970018178 FAD binding motif [chemical binding]; other site 1114970018179 phosphate binding motif [ion binding]; other site 1114970018180 beta-alpha-beta structure motif; other site 1114970018181 NAD binding pocket [chemical binding]; other site 1114970018182 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 1114970018183 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1114970018184 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1114970018185 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1114970018186 RNA binding site [nucleotide binding]; other site 1114970018187 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1114970018188 multimer interface [polypeptide binding]; other site 1114970018189 Walker A motif; other site 1114970018190 ATP binding site [chemical binding]; other site 1114970018191 Walker B motif; other site 1114970018192 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1114970018193 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1114970018194 catalytic residues [active] 1114970018195 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1114970018196 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970018197 DNA-binding site [nucleotide binding]; DNA binding site 1114970018198 FCD domain; Region: FCD; pfam07729 1114970018199 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970018200 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970018201 substrate binding pocket [chemical binding]; other site 1114970018202 membrane-bound complex binding site; other site 1114970018203 hinge residues; other site 1114970018204 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114970018205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970018206 dimer interface [polypeptide binding]; other site 1114970018207 conserved gate region; other site 1114970018208 putative PBP binding loops; other site 1114970018209 ABC-ATPase subunit interface; other site 1114970018210 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114970018211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970018212 dimer interface [polypeptide binding]; other site 1114970018213 conserved gate region; other site 1114970018214 putative PBP binding loops; other site 1114970018215 ABC-ATPase subunit interface; other site 1114970018216 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1114970018217 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1114970018218 Walker A/P-loop; other site 1114970018219 ATP binding site [chemical binding]; other site 1114970018220 Q-loop/lid; other site 1114970018221 ABC transporter signature motif; other site 1114970018222 Walker B; other site 1114970018223 D-loop; other site 1114970018224 H-loop/switch region; other site 1114970018225 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1114970018226 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1114970018227 polyphosphate kinase; Provisional; Region: PRK05443 1114970018228 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1114970018229 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1114970018230 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1114970018231 putative active site [active] 1114970018232 catalytic site [active] 1114970018233 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1114970018234 putative domain interface [polypeptide binding]; other site 1114970018235 putative active site [active] 1114970018236 catalytic site [active] 1114970018237 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 1114970018238 dimer interface [polypeptide binding]; other site 1114970018239 allosteric magnesium binding site [ion binding]; other site 1114970018240 active site 1114970018241 aspartate-rich active site metal binding site; other site 1114970018242 Schiff base residues; other site 1114970018243 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1114970018244 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1114970018245 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1114970018246 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1114970018247 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 1114970018248 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 1114970018249 conserved cys residue [active] 1114970018250 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 1114970018251 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1114970018252 Cytochrome c; Region: Cytochrom_C; pfam00034 1114970018253 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 1114970018254 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 1114970018255 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 1114970018256 putative dimer interface [polypeptide binding]; other site 1114970018257 Protein of unknown function (DUF3897); Region: DUF3897; pfam13036 1114970018258 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 1114970018259 LysE type translocator; Region: LysE; cl00565 1114970018260 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1114970018261 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1114970018262 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 1114970018263 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114970018264 Walker A/P-loop; other site 1114970018265 ATP binding site [chemical binding]; other site 1114970018266 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1114970018267 ABC transporter signature motif; other site 1114970018268 Walker B; other site 1114970018269 D-loop; other site 1114970018270 ABC transporter; Region: ABC_tran_2; pfam12848 1114970018271 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1114970018272 Protein of unknown function (DUF2390); Region: DUF2390; pfam09523 1114970018273 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1114970018274 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1114970018275 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1114970018276 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 1114970018277 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 1114970018278 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 1114970018279 HemY protein N-terminus; Region: HemY_N; pfam07219 1114970018280 uroporphyrinogen-III synthase; Validated; Region: PRK05752 1114970018281 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1114970018282 active site 1114970018283 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1114970018284 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1114970018285 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1114970018286 domain interfaces; other site 1114970018287 active site 1114970018288 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1114970018289 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114970018290 active site 1114970018291 phosphorylation site [posttranslational modification] 1114970018292 intermolecular recognition site; other site 1114970018293 LytTr DNA-binding domain; Region: LytTR; pfam04397 1114970018294 argininosuccinate lyase; Provisional; Region: PRK00855 1114970018295 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1114970018296 active sites [active] 1114970018297 tetramer interface [polypeptide binding]; other site 1114970018298 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1114970018299 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1114970018300 C-terminal domain interface [polypeptide binding]; other site 1114970018301 GSH binding site (G-site) [chemical binding]; other site 1114970018302 dimer interface [polypeptide binding]; other site 1114970018303 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1114970018304 N-terminal domain interface [polypeptide binding]; other site 1114970018305 dimer interface [polypeptide binding]; other site 1114970018306 substrate binding pocket (H-site) [chemical binding]; other site 1114970018307 TIGR02647 family protein; Region: DNA 1114970018308 adenylate cyclase; Provisional; Region: cyaA; PRK09450 1114970018309 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 1114970018310 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 1114970018311 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1114970018312 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1114970018313 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 1114970018314 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 1114970018315 putative iron binding site [ion binding]; other site 1114970018316 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1114970018317 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1114970018318 active site 1114970018319 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1114970018320 substrate binding site [chemical binding]; other site 1114970018321 catalytic residues [active] 1114970018322 dimer interface [polypeptide binding]; other site 1114970018323 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1114970018324 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1114970018325 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1114970018326 Protein of unknown function, DUF484; Region: DUF484; cl17449 1114970018327 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1114970018328 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1114970018329 active site 1114970018330 DNA binding site [nucleotide binding] 1114970018331 Int/Topo IB signature motif; other site 1114970018332 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 1114970018333 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114970018334 motif II; other site 1114970018335 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1114970018336 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1114970018337 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1114970018338 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1114970018339 Membrane fusogenic activity; Region: BMFP; pfam04380 1114970018340 BRO family, N-terminal domain; Region: Bro-N; smart01040 1114970018341 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1114970018342 VirC1 protein; Region: VirC1; cl17401 1114970018343 Membrane fusogenic activity; Region: BMFP; pfam04380 1114970018344 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114970018345 ATP binding site [chemical binding]; other site 1114970018346 Mg2+ binding site [ion binding]; other site 1114970018347 G-X-G motif; other site 1114970018348 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1114970018349 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1114970018350 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1114970018351 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1114970018352 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1114970018353 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1114970018354 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114970018355 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1114970018356 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1114970018357 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1114970018358 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1114970018359 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 1114970018360 active site 1114970018361 catalytic residues [active] 1114970018362 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114970018363 dimerization interface [polypeptide binding]; other site 1114970018364 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114970018365 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114970018366 dimer interface [polypeptide binding]; other site 1114970018367 putative CheW interface [polypeptide binding]; other site 1114970018368 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1114970018369 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970018370 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1114970018371 dimerization interface [polypeptide binding]; other site 1114970018372 substrate binding pocket [chemical binding]; other site 1114970018373 multidrug efflux protein NorA; Provisional; Region: PRK00187 1114970018374 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1114970018375 cation binding site [ion binding]; other site 1114970018376 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114970018377 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970018378 metal binding site [ion binding]; metal-binding site 1114970018379 active site 1114970018380 I-site; other site 1114970018381 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970018382 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 1114970018383 Family description; Region: UvrD_C_2; pfam13538 1114970018384 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114970018385 active site 1114970018386 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 1114970018387 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1114970018388 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 1114970018389 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1114970018390 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114970018391 non-specific DNA binding site [nucleotide binding]; other site 1114970018392 salt bridge; other site 1114970018393 sequence-specific DNA binding site [nucleotide binding]; other site 1114970018394 Cupin domain; Region: Cupin_2; pfam07883 1114970018395 alanine racemase; Reviewed; Region: dadX; PRK03646 1114970018396 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1114970018397 active site 1114970018398 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1114970018399 substrate binding site [chemical binding]; other site 1114970018400 catalytic residues [active] 1114970018401 dimer interface [polypeptide binding]; other site 1114970018402 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1114970018403 homotrimer interaction site [polypeptide binding]; other site 1114970018404 putative active site [active] 1114970018405 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1114970018406 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1114970018407 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1114970018408 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114970018409 putative DNA binding site [nucleotide binding]; other site 1114970018410 putative Zn2+ binding site [ion binding]; other site 1114970018411 AsnC family; Region: AsnC_trans_reg; pfam01037 1114970018412 Flagellin N-methylase; Region: FliB; pfam03692 1114970018413 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1114970018414 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1114970018415 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 1114970018416 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1114970018417 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970018418 DNA-binding site [nucleotide binding]; DNA binding site 1114970018419 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970018420 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970018421 homodimer interface [polypeptide binding]; other site 1114970018422 catalytic residue [active] 1114970018423 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 1114970018424 PLD-like domain; Region: PLDc_2; pfam13091 1114970018425 putative active site [active] 1114970018426 catalytic site [active] 1114970018427 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 1114970018428 PLD-like domain; Region: PLDc_2; pfam13091 1114970018429 putative active site [active] 1114970018430 catalytic site [active] 1114970018431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114970018432 putative substrate translocation pore; other site 1114970018433 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114970018434 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 1114970018435 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1114970018436 NAD(P) binding site [chemical binding]; other site 1114970018437 catalytic residues [active] 1114970018438 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 1114970018439 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1114970018440 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1114970018441 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1114970018442 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1114970018443 peptide binding site [polypeptide binding]; other site 1114970018444 hypothetical protein; Reviewed; Region: PRK00024 1114970018445 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1114970018446 MPN+ (JAMM) motif; other site 1114970018447 Zinc-binding site [ion binding]; other site 1114970018448 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1114970018449 Flavoprotein; Region: Flavoprotein; pfam02441 1114970018450 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1114970018451 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1114970018452 trimer interface [polypeptide binding]; other site 1114970018453 active site 1114970018454 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1114970018455 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1114970018456 active site 1114970018457 substrate binding site [chemical binding]; other site 1114970018458 metal binding site [ion binding]; metal-binding site 1114970018459 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1114970018460 feedback inhibition sensing region; other site 1114970018461 homohexameric interface [polypeptide binding]; other site 1114970018462 nucleotide binding site [chemical binding]; other site 1114970018463 N-acetyl-L-glutamate binding site [chemical binding]; other site 1114970018464 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114970018465 active site 1114970018466 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1114970018467 putative active site [active] 1114970018468 putative catalytic site [active] 1114970018469 putative DNA binding site [nucleotide binding]; other site 1114970018470 putative phosphate binding site [ion binding]; other site 1114970018471 metal binding site A [ion binding]; metal-binding site 1114970018472 putative AP binding site [nucleotide binding]; other site 1114970018473 putative metal binding site B [ion binding]; other site 1114970018474 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 1114970018475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 1114970018476 ribonuclease PH; Reviewed; Region: rph; PRK00173 1114970018477 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1114970018478 hexamer interface [polypeptide binding]; other site 1114970018479 active site 1114970018480 hypothetical protein; Provisional; Region: PRK11820 1114970018481 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1114970018482 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1114970018483 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1114970018484 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1114970018485 catalytic site [active] 1114970018486 G-X2-G-X-G-K; other site 1114970018487 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1114970018488 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 1114970018489 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1114970018490 Zn2+ binding site [ion binding]; other site 1114970018491 Mg2+ binding site [ion binding]; other site 1114970018492 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1114970018493 synthetase active site [active] 1114970018494 NTP binding site [chemical binding]; other site 1114970018495 metal binding site [ion binding]; metal-binding site 1114970018496 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1114970018497 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1114970018498 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1114970018499 homotrimer interaction site [polypeptide binding]; other site 1114970018500 putative active site [active] 1114970018501 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1114970018502 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970018503 NAD(P) binding site [chemical binding]; other site 1114970018504 active site 1114970018505 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1114970018506 biopolymer transport protein ExbD; Provisional; Region: PRK11267 1114970018507 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1114970018508 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1114970018509 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1114970018510 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1114970018511 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970018512 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1114970018513 dimerization interface [polypeptide binding]; other site 1114970018514 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1114970018515 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1114970018516 generic binding surface II; other site 1114970018517 ssDNA binding site; other site 1114970018518 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114970018519 ATP binding site [chemical binding]; other site 1114970018520 putative Mg++ binding site [ion binding]; other site 1114970018521 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114970018522 nucleotide binding region [chemical binding]; other site 1114970018523 ATP-binding site [chemical binding]; other site 1114970018524 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 1114970018525 putative deacylase active site [active] 1114970018526 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 1114970018527 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1114970018528 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1114970018529 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1114970018530 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114970018531 Walker A/P-loop; other site 1114970018532 ATP binding site [chemical binding]; other site 1114970018533 Q-loop/lid; other site 1114970018534 ABC transporter signature motif; other site 1114970018535 Walker B; other site 1114970018536 D-loop; other site 1114970018537 H-loop/switch region; other site 1114970018538 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1114970018539 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1114970018540 active site 1114970018541 ATP binding site [chemical binding]; other site 1114970018542 substrate binding site [chemical binding]; other site 1114970018543 activation loop (A-loop); other site 1114970018544 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1114970018545 metal ion-dependent adhesion site (MIDAS); other site 1114970018546 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1114970018547 Protein phosphatase 2C; Region: PP2C; pfam00481 1114970018548 active site 1114970018549 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 1114970018550 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 1114970018551 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1114970018552 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1114970018553 hypothetical protein; Provisional; Region: PRK07033 1114970018554 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 1114970018555 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1114970018556 ligand binding site [chemical binding]; other site 1114970018557 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 1114970018558 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1114970018559 type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352 1114970018560 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1114970018561 phosphopeptide binding site; other site 1114970018562 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 1114970018563 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1114970018564 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 1114970018565 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 1114970018566 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1114970018567 Protein of unknown function (DUF796); Region: DUF796; pfam05638 1114970018568 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 1114970018569 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 1114970018570 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1114970018571 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1114970018572 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 1114970018573 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1114970018574 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970018575 Walker A motif; other site 1114970018576 ATP binding site [chemical binding]; other site 1114970018577 Walker B motif; other site 1114970018578 arginine finger; other site 1114970018579 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970018580 Walker A motif; other site 1114970018581 ATP binding site [chemical binding]; other site 1114970018582 Walker B motif; other site 1114970018583 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1114970018584 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1114970018585 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1114970018586 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1114970018587 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 1114970018588 PAAR motif; Region: PAAR_motif; pfam05488 1114970018589 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1114970018590 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1114970018591 RHS Repeat; Region: RHS_repeat; pfam05593 1114970018592 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1114970018593 RHS Repeat; Region: RHS_repeat; pfam05593 1114970018594 RHS Repeat; Region: RHS_repeat; pfam05593 1114970018595 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1114970018596 RHS Repeat; Region: RHS_repeat; cl11982 1114970018597 RHS protein; Region: RHS; pfam03527 1114970018598 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1114970018599 RES domain; Region: RES; smart00953 1114970018600 PAAR motif; Region: PAAR_motif; pfam05488 1114970018601 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1114970018602 RHS Repeat; Region: RHS_repeat; pfam05593 1114970018603 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1114970018604 RHS Repeat; Region: RHS_repeat; pfam05593 1114970018605 RHS Repeat; Region: RHS_repeat; pfam05593 1114970018606 RHS Repeat; Region: RHS_repeat; pfam05593 1114970018607 RHS Repeat; Region: RHS_repeat; pfam05593 1114970018608 RHS Repeat; Region: RHS_repeat; cl11982 1114970018609 RHS Repeat; Region: RHS_repeat; cl11982 1114970018610 RHS protein; Region: RHS; pfam03527 1114970018611 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1114970018612 A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414 1114970018613 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 1114970018614 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1114970018615 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1114970018616 active site 1114970018617 ATP binding site [chemical binding]; other site 1114970018618 substrate binding site [chemical binding]; other site 1114970018619 activation loop (A-loop); other site 1114970018620 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1114970018621 active site 1114970018622 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 1114970018623 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1114970018624 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1114970018625 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 1114970018626 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 1114970018627 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1114970018628 type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352 1114970018629 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 1114970018630 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1114970018631 phosphopeptide binding site; other site 1114970018632 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 1114970018633 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970018634 Walker A motif; other site 1114970018635 ATP binding site [chemical binding]; other site 1114970018636 Walker B motif; other site 1114970018637 arginine finger; other site 1114970018638 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1114970018639 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1114970018640 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970018641 Walker A motif; other site 1114970018642 ATP binding site [chemical binding]; other site 1114970018643 Walker B motif; other site 1114970018644 arginine finger; other site 1114970018645 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114970018646 Walker A motif; other site 1114970018647 ATP binding site [chemical binding]; other site 1114970018648 Walker B motif; other site 1114970018649 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1114970018650 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 1114970018651 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1114970018652 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1114970018653 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 1114970018654 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 1114970018655 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1114970018656 Protein of unknown function (DUF770); Region: DUF770; pfam05591 1114970018657 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 1114970018658 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1114970018659 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 1114970018660 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1114970018661 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1114970018662 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1114970018663 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 1114970018664 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 1114970018665 active site flap/lid [active] 1114970018666 nucleophilic elbow; other site 1114970018667 catalytic triad [active] 1114970018668 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 1114970018669 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1114970018670 active site 1114970018671 Zn binding site [ion binding]; other site 1114970018672 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1114970018673 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1114970018674 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1114970018675 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114970018676 DNA-binding site [nucleotide binding]; DNA binding site 1114970018677 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114970018678 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114970018679 homodimer interface [polypeptide binding]; other site 1114970018680 catalytic residue [active] 1114970018681 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 1114970018682 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1114970018683 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114970018684 Coenzyme A binding pocket [chemical binding]; other site 1114970018685 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1114970018686 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1114970018687 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1114970018688 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040 1114970018689 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1114970018690 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114970018691 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114970018692 substrate binding pocket [chemical binding]; other site 1114970018693 membrane-bound complex binding site; other site 1114970018694 hinge residues; other site 1114970018695 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114970018696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114970018697 dimer interface [polypeptide binding]; other site 1114970018698 conserved gate region; other site 1114970018699 putative PBP binding loops; other site 1114970018700 ABC-ATPase subunit interface; other site 1114970018701 Autotransporter beta-domain; Region: Autotransporter; smart00869 1114970018702 pyruvate carboxylase subunit B; Validated; Region: PRK09282 1114970018703 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1114970018704 active site 1114970018705 catalytic residues [active] 1114970018706 metal binding site [ion binding]; metal-binding site 1114970018707 homodimer binding site [polypeptide binding]; other site 1114970018708 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1114970018709 carboxyltransferase (CT) interaction site; other site 1114970018710 biotinylation site [posttranslational modification]; other site 1114970018711 pyruvate carboxylase subunit A; Validated; Region: PRK07178 1114970018712 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1114970018713 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1114970018714 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1114970018715 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114970018716 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970018717 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 1114970018718 putative dimerization interface [polypeptide binding]; other site 1114970018719 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1114970018720 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1114970018721 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1114970018722 putative active site [active] 1114970018723 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970018724 PAS fold; Region: PAS_3; pfam08447 1114970018725 putative active site [active] 1114970018726 heme pocket [chemical binding]; other site 1114970018727 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114970018728 PAS domain; Region: PAS_9; pfam13426 1114970018729 putative active site [active] 1114970018730 heme pocket [chemical binding]; other site 1114970018731 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114970018732 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114970018733 metal binding site [ion binding]; metal-binding site 1114970018734 active site 1114970018735 I-site; other site 1114970018736 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114970018737 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1114970018738 Part of AAA domain; Region: AAA_19; pfam13245 1114970018739 Family description; Region: UvrD_C_2; pfam13538 1114970018740 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 1114970018741 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1114970018742 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1114970018743 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1114970018744 pyridoxamine kinase; Validated; Region: PRK05756 1114970018745 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1114970018746 pyridoxal binding site [chemical binding]; other site 1114970018747 dimer interface [polypeptide binding]; other site 1114970018748 ATP binding site [chemical binding]; other site 1114970018749 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 1114970018750 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1114970018751 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1114970018752 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1114970018753 Protein of unknown function (DUF1826); Region: DUF1826; pfam08856 1114970018754 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1114970018755 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1114970018756 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1114970018757 putative GTP cyclohydrolase; Provisional; Region: PRK13674 1114970018758 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1114970018759 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114970018760 Walker A/P-loop; other site 1114970018761 ATP binding site [chemical binding]; other site 1114970018762 Q-loop/lid; other site 1114970018763 ABC transporter signature motif; other site 1114970018764 Walker B; other site 1114970018765 D-loop; other site 1114970018766 H-loop/switch region; other site 1114970018767 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1114970018768 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1114970018769 ABC-ATPase subunit interface; other site 1114970018770 dimer interface [polypeptide binding]; other site 1114970018771 putative PBP binding regions; other site 1114970018772 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1114970018773 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1114970018774 metal binding site [ion binding]; metal-binding site 1114970018775 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 1114970018776 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1114970018777 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1114970018778 Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155 1114970018779 putative active site [active] 1114970018780 catalytic site [active] 1114970018781 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1114970018782 putative active site [active] 1114970018783 catalytic site [active] 1114970018784 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1114970018785 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970018786 S-adenosylmethionine binding site [chemical binding]; other site 1114970018787 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1114970018788 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1114970018789 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1114970018790 HflK protein; Region: hflK; TIGR01933 1114970018791 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1114970018792 HflC protein; Region: hflC; TIGR01932 1114970018793 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1114970018794 HflK protein; Region: hflK; TIGR01933 1114970018795 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06115 1114970018796 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1114970018797 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114970018798 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1114970018799 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 1114970018800 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1114970018801 S-adenosylmethionine binding site [chemical binding]; other site 1114970018802 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1114970018803 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1114970018804 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1114970018805 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1114970018806 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114970018807 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 1114970018808 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114970018809 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1114970018810 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1114970018811 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114970018812 NAD(P) binding site [chemical binding]; other site 1114970018813 active site 1114970018814 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1114970018815 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1114970018816 NADP-binding site; other site 1114970018817 homotetramer interface [polypeptide binding]; other site 1114970018818 substrate binding site [chemical binding]; other site 1114970018819 homodimer interface [polypeptide binding]; other site 1114970018820 active site 1114970018821 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1114970018822 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1114970018823 Substrate binding site; other site 1114970018824 Cupin domain; Region: Cupin_2; cl17218 1114970018825 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1114970018826 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1114970018827 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1114970018828 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1114970018829 Walker A/P-loop; other site 1114970018830 ATP binding site [chemical binding]; other site 1114970018831 Q-loop/lid; other site 1114970018832 ABC transporter signature motif; other site 1114970018833 Walker B; other site 1114970018834 D-loop; other site 1114970018835 H-loop/switch region; other site 1114970018836 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 1114970018837 putative carbohydrate binding site [chemical binding]; other site 1114970018838 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1114970018839 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1114970018840 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114970018841 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114970018842 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1114970018843 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114970018844 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 1114970018845 putative ADP-binding pocket [chemical binding]; other site 1114970018846 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 1114970018847 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1114970018848 putative C-terminal domain interface [polypeptide binding]; other site 1114970018849 putative GSH binding site (G-site) [chemical binding]; other site 1114970018850 putative dimer interface [polypeptide binding]; other site 1114970018851 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 1114970018852 putative N-terminal domain interface [polypeptide binding]; other site 1114970018853 putative dimer interface [polypeptide binding]; other site 1114970018854 putative substrate binding pocket (H-site) [chemical binding]; other site 1114970018855 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114970018856 LysR family transcriptional regulator; Provisional; Region: PRK14997 1114970018857 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 1114970018858 putative effector binding pocket; other site 1114970018859 putative dimerization interface [polypeptide binding]; other site 1114970018860 Sulfatase; Region: Sulfatase; pfam00884 1114970018861 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1114970018862 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1114970018863 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1114970018864 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1114970018865 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1114970018866 conserved cys residue [active] 1114970018867 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970018868 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114970018869 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 1114970018870 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1114970018871 dimer interface [polypeptide binding]; other site 1114970018872 ADP-ribose binding site [chemical binding]; other site 1114970018873 active site 1114970018874 nudix motif; other site 1114970018875 metal binding site [ion binding]; metal-binding site 1114970018876 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1114970018877 FAD binding domain; Region: FAD_binding_4; pfam01565 1114970018878 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1114970018879 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1114970018880 active site pocket [active] 1114970018881 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 1114970018882 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1114970018883 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1114970018884 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1114970018885 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1114970018886 glutaminase active site [active] 1114970018887 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1114970018888 dimer interface [polypeptide binding]; other site 1114970018889 active site 1114970018890 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1114970018891 dimer interface [polypeptide binding]; other site 1114970018892 active site 1114970018893 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114970018894 putative DNA binding site [nucleotide binding]; other site 1114970018895 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 1114970018896 putative Zn2+ binding site [ion binding]; other site 1114970018897 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1114970018898 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 1114970018899 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1114970018900 Substrate binding site; other site 1114970018901 Mg++ binding site; other site 1114970018902 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1114970018903 active site 1114970018904 substrate binding site [chemical binding]; other site 1114970018905 CoA binding site [chemical binding]; other site 1114970018906 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1114970018907 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1114970018908 gamma subunit interface [polypeptide binding]; other site 1114970018909 epsilon subunit interface [polypeptide binding]; other site 1114970018910 LBP interface [polypeptide binding]; other site 1114970018911 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1114970018912 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1114970018913 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1114970018914 alpha subunit interaction interface [polypeptide binding]; other site 1114970018915 Walker A motif; other site 1114970018916 ATP binding site [chemical binding]; other site 1114970018917 Walker B motif; other site 1114970018918 inhibitor binding site; inhibition site 1114970018919 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1114970018920 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1114970018921 core domain interface [polypeptide binding]; other site 1114970018922 delta subunit interface [polypeptide binding]; other site 1114970018923 epsilon subunit interface [polypeptide binding]; other site 1114970018924 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1114970018925 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1114970018926 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1114970018927 beta subunit interaction interface [polypeptide binding]; other site 1114970018928 Walker A motif; other site 1114970018929 ATP binding site [chemical binding]; other site 1114970018930 Walker B motif; other site 1114970018931 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1114970018932 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1114970018933 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1114970018934 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1114970018935 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1114970018936 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1114970018937 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1114970018938 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1114970018939 F0F1 ATP synthase subunit I; Validated; Region: PRK05760 1114970018940 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1114970018941 ParB-like nuclease domain; Region: ParBc; pfam02195 1114970018942 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1114970018943 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1114970018944 Magnesium ion binding site [ion binding]; other site 1114970018945 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1114970018946 Magnesium ion binding site [ion binding]; other site 1114970018947 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 1114970018948 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114970018949 S-adenosylmethionine binding site [chemical binding]; other site 1114970018950 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1114970018951 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 1114970018952 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1114970018953 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1114970018954 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1114970018955 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1114970018956 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1114970018957 G1 box; other site 1114970018958 GTP/Mg2+ binding site [chemical binding]; other site 1114970018959 Switch I region; other site 1114970018960 G2 box; other site 1114970018961 Switch II region; other site 1114970018962 G3 box; other site 1114970018963 G4 box; other site 1114970018964 G5 box; other site 1114970018965 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1114970018966 membrane protein insertase; Provisional; Region: PRK01318 1114970018967 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1114970018968 Ribonuclease P; Region: Ribonuclease_P; cl00457