-- dump date   	20140620_005513
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
216595000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
216595000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595000003	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
216595000004	Walker A motif; other site
216595000005	ATP binding site [chemical binding]; other site
216595000006	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
216595000007	Walker B motif; other site
216595000008	arginine finger; other site
216595000009	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
216595000010	DnaA box-binding interface [nucleotide binding]; other site
216595000012	PS00017 ATP/GTP-binding site motif A (P-loop).
216595000014	PS01008 DnaA protein signature.
216595000015	DNA polymerase III subunit beta; Validated; Region: PRK05643
216595000016	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
216595000017	putative DNA binding surface [nucleotide binding]; other site
216595000018	dimer interface [polypeptide binding]; other site
216595000019	beta-clamp/clamp loader binding surface; other site
216595000020	beta-clamp/translesion DNA polymerase binding surface; other site
216595000024	recombination protein F; Reviewed; Region: recF; PRK00064
216595000025	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216595000026	Walker A/P-loop; other site
216595000027	ATP binding site [chemical binding]; other site
216595000028	Q-loop/lid; other site
216595000029	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216595000030	ABC transporter signature motif; other site
216595000031	Walker B; other site
216595000032	D-loop; other site
216595000033	H-loop/switch region; other site
216595000035	PS00017 ATP/GTP-binding site motif A (P-loop).
216595000036	PS00617 RecF protein signature 1.
216595000037	PS00618 RecF protein signature 2.
216595000038	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
216595000039	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595000040	Mg2+ binding site [ion binding]; other site
216595000041	G-X-G motif; other site
216595000042	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
216595000043	anchoring element; other site
216595000044	dimer interface [polypeptide binding]; other site
216595000045	ATP binding site [chemical binding]; other site
216595000046	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
216595000047	active site
216595000048	putative metal-binding site [ion binding]; other site
216595000049	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
216595000053	PS00177 DNA topoisomerase II signature.
216595000055	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
216595000056	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595000057	active site
216595000058	phosphorylation site [posttranslational modification]
216595000059	intermolecular recognition site; other site
216595000060	dimerization interface [polypeptide binding]; other site
216595000061	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216595000062	DNA binding site [nucleotide binding]
216595000064	PS00310 Lysosome-associated membrane glycoproteins duplicated domain signature.
216595000066	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254
216595000067	FecR protein; Region: FecR; pfam04773
216595000069	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
216595000070	CHASE2 domain; Region: CHASE2; pfam05226
216595000071	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
216595000072	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595000073	dimer interface [polypeptide binding]; other site
216595000074	phosphorylation site [posttranslational modification]
216595000075	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595000076	ATP binding site [chemical binding]; other site
216595000077	Mg2+ binding site [ion binding]; other site
216595000078	G-X-G motif; other site
216595000079	4 probable transmembrane helices predicted for PFLU0007 by TMHMM2.0 at aa 26-48, 305-327, 332-351 and 356-375
216595000081	PS00215 Mitochondrial energy transfer proteins signature.
216595000085	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
216595000086	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
216595000087	putative acyl-acceptor binding pocket; other site
216595000089	1 probable transmembrane helix predicted for PFLU0008 by TMHMM2.0 at aa 46-68
216595000090	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
216595000091	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216595000092	active site
216595000093	motif I; other site
216595000094	motif II; other site
216595000096	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
216595000097	HD domain; Region: HD; pfam01966
216595000098	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
216595000101	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
216595000102	dimer interface [polypeptide binding]; other site
216595000103	motif 1; other site
216595000104	active site
216595000105	motif 2; other site
216595000106	motif 3; other site
216595000108	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
216595000109	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
216595000111	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
216595000112	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
216595000113	putative acyl-acceptor binding pocket; other site
216595000115	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
216595000116	TPR motif; other site
216595000117	binding surface
216595000120	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
216595000121	TrkA-N domain; Region: TrkA_N; pfam02254
216595000122	TrkA-C domain; Region: TrkA_C; pfam02080
216595000123	TrkA-N domain; Region: TrkA_N; pfam02254
216595000124	TrkA-C domain; Region: TrkA_C; pfam02080
216595000129	16S rRNA methyltransferase B; Provisional; Region: PRK10901
216595000130	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
216595000131	putative RNA binding site [nucleotide binding]; other site
216595000132	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595000133	S-adenosylmethionine binding site [chemical binding]; other site
216595000136	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
216595000137	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
216595000138	putative active site [active]
216595000139	substrate binding site [chemical binding]; other site
216595000140	putative cosubstrate binding site; other site
216595000141	catalytic site [active]
216595000142	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
216595000143	substrate binding site [chemical binding]; other site
216595000146	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
216595000147	active site
216595000148	catalytic residues [active]
216595000149	metal binding site [ion binding]; metal-binding site
216595000151	PS00017 ATP/GTP-binding site motif A (P-loop).
216595000152	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
216595000153	DNA protecting protein DprA; Region: dprA; TIGR00732
216595000155	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
216595000157	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
216595000158	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
216595000159	NADP binding site [chemical binding]; other site
216595000160	dimer interface [polypeptide binding]; other site
216595000162	PS01162 Quinone oxidoreductase / zeta-crystallin signature.
216595000164	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
216595000165	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
216595000167	PS01021 Coproporphyrinogen III oxidase signature.
216595000168	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
216595000169	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
216595000170	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
216595000171	shikimate binding site; other site
216595000172	NAD(P) binding site [chemical binding]; other site
216595000175	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
216595000176	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
216595000177	Sulfate transporter family; Region: Sulfate_transp; pfam00916
216595000178	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
216595000181	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
216595000182	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
216595000184	Sulfatase; Region: Sulfatase; cl17466
216595000185	choline-sulfatase; Region: chol_sulfatase; TIGR03417
216595000186	Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411
216595000188	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
216595000189	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595000190	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
216595000191	dimerization interface [polypeptide binding]; other site
216595000193	PS00044 Bacterial regulatory proteins, lysR family signature.
216595000195	Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883
216595000197	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
216595000198	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
216595000200	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
216595000201	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
216595000202	active site
216595000203	intersubunit interface [polypeptide binding]; other site
216595000204	catalytic residue [active]
216595000206	PS00160 KDPG and KHG aldolases Schiff-base forming residue.
216595000207	galactonate dehydratase; Provisional; Region: PRK14017
216595000208	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
216595000209	putative active site pocket [active]
216595000210	putative metal binding site [ion binding]; other site
216595000212	PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1.
216595000214	PS00909 Mandelate racemase / muconate lactonizing enzyme family signature 2.
216595000215	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595000216	D-galactonate transporter; Region: 2A0114; TIGR00893
216595000217	putative substrate translocation pore; other site
216595000218	11 probable transmembrane helices predicted for PFLU0033 by TMHMM2.0 at aa 20-35, 56-78, 93-115, 146-168, 173-195, 246-268, 283-302, 315-337, 342-364, 377-399 and 404-426
216595000220	Domain of unknown function (DUF3315); Region: DUF3315; cl02275
216595000221	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
216595000222	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
216595000223	substrate binding site [chemical binding]; other site
216595000224	active site
216595000225	catalytic residues [active]
216595000226	heterodimer interface [polypeptide binding]; other site
216595000228	PS00201 Flavodoxin signature.
216595000229	PS00167 Tryptophan synthase alpha chain signature.
216595000230	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
216595000231	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
216595000232	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595000233	catalytic residue [active]
216595000235	PS00168 Tryptophan synthase beta chain pyridoxal-phosphate attachment site.
216595000236	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
216595000237	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595000238	The C-terminal substrate binding domain of LysR-type transcriptional regulator TrpI, which is involved in control of tryptophan synthesis, contains type 2 periplasmic binding fold; Region: PBP2_TrpI; cd08482
216595000239	putative dimerization interface [polypeptide binding]; other site
216595000240	putative substrate binding pocket [chemical binding]; other site
216595000242	PS00044 Bacterial regulatory proteins, lysR family signature.
216595000244	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
216595000246	1 probable transmembrane helix predicted for PFLU0038 by TMHMM2.0 at aa 85-104
216595000247	Dodecin; Region: Dodecin; pfam07311
216595000249	Protein of unknown function (DUF1161); Region: DUF1161; pfam06649
216595000251	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
216595000252	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
216595000254	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
216595000256	Protein of unknown function (DUF1161); Region: DUF1161; pfam06649
216595000258	PS00443 Glutamine amidotransferases class-II active site.
216595000259	Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023
216595000260	1 probable transmembrane helix predicted for PFLU0045 by TMHMM2.0 at aa 33-55
216595000261	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595000262	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
216595000263	Eukaryotic phosphomannomutase; Region: PMM; cl17107
216595000264	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216595000265	motif II; other site
216595000267	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
216595000268	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
216595000269	trimer interface [polypeptide binding]; other site
216595000270	putative metal binding site [ion binding]; other site
216595000276	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
216595000277	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
216595000278	active site
216595000279	Zn binding site [ion binding]; other site
216595000281	PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.
216595000282	Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526
216595000283	Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162
216595000285	PS00383 Tyrosine specific protein phosphatases active site.
216595000286	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
216595000287	1 probable transmembrane helix predicted for PFLU0051 by TMHMM2.0 at aa 17-39
216595000288	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
216595000289	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
216595000291	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
216595000292	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
216595000293	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
216595000294	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595000295	PS00190 Cytochrome c family heme-binding site signature.
216595000296	PS00190 Cytochrome c family heme-binding site signature.
216595000298	PS00190 Cytochrome c family heme-binding site signature.
216595000299	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
216595000300	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216595000301	FeS/SAM binding site; other site
216595000303	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
216595000304	active site clefts [active]
216595000305	zinc binding site [ion binding]; other site
216595000306	dimer interface [polypeptide binding]; other site
216595000308	PS00704 Prokaryotic-type carbonic anhydrases signature 1.
216595000309	PS00705 Prokaryotic-type carbonic anhydrases signature 2.
216595000310	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
216595000311	Sulfate transporter family; Region: Sulfate_transp; pfam00916
216595000312	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
216595000313	10 probable transmembrane helices predicted for PFLU0056 by TMHMM2.0 at aa 15-37, 44-66, 81-103, 115-137, 152-174, 195-217, 246-268, 288-310, 325-356 and 377-399
216595000315	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
216595000316	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
216595000317	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
216595000318	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
216595000319	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
216595000320	3 probable transmembrane helices predicted for PFLU0058 by TMHMM2.0 at aa 7-29, 44-66 and 87-104
216595000323	PS00078 CO II and nitrous oxide reductase dinuclear copper centers signature.
216595000325	PS00190 Cytochrome c family heme-binding site signature.
216595000326	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
216595000327	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
216595000328	Subunit I/III interface [polypeptide binding]; other site
216595000329	D-pathway; other site
216595000330	Subunit I/VIIc interface [polypeptide binding]; other site
216595000331	Subunit I/IV interface [polypeptide binding]; other site
216595000332	Subunit I/II interface [polypeptide binding]; other site
216595000333	Low-spin heme (heme a) binding site [chemical binding]; other site
216595000334	Subunit I/VIIa interface [polypeptide binding]; other site
216595000335	Subunit I/VIa interface [polypeptide binding]; other site
216595000336	Dimer interface; other site
216595000337	Putative water exit pathway; other site
216595000338	Binuclear center (heme a3/CuB) [ion binding]; other site
216595000339	K-pathway; other site
216595000340	Subunit I/Vb interface [polypeptide binding]; other site
216595000341	Putative proton exit pathway; other site
216595000342	Subunit I/VIb interface; other site
216595000343	Subunit I/VIc interface [polypeptide binding]; other site
216595000344	Electron transfer pathway; other site
216595000345	Subunit I/VIIIb interface [polypeptide binding]; other site
216595000346	Subunit I/VIIb interface [polypeptide binding]; other site
216595000348	12 probable transmembrane helices predicted for PFLU0059 by TMHMM2.0 at aa 33-55, 75-97, 117-139, 159-181, 201-223, 252-274, 281-303, 318-340, 353-375, 390-412, 429-451 and 466-488
216595000349	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595000350	PS00077 Heme-copper oxidase catalytic subunit, copper B binding region signature.
216595000351	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
216595000352	1 probable transmembrane helix predicted for PFLU0060 by TMHMM2.0 at aa 49-71
216595000354	PS00017 ATP/GTP-binding site motif A (P-loop).
216595000355	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
216595000356	Subunit III/VIIa interface [polypeptide binding]; other site
216595000357	Phospholipid binding site [chemical binding]; other site
216595000358	Subunit I/III interface [polypeptide binding]; other site
216595000359	Subunit III/VIb interface [polypeptide binding]; other site
216595000360	Subunit III/VIa interface; other site
216595000361	Subunit III/Vb interface [polypeptide binding]; other site
216595000362	6 probable transmembrane helices predicted for PFLU0061 by TMHMM2.0 at aa 15-34, 46-68, 88-110, 191-213, 233-255 and 275-294
216595000364	Protein of unknown function (DUF2909); Region: DUF2909; pfam11137
216595000365	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
216595000366	2 probable transmembrane helices predicted for PFLU0063 by TMHMM2.0 at aa 15-37 and 214-236
216595000367	1 probable transmembrane helix predicted for PFLU0064 by TMHMM2.0 at aa 21-43
216595000368	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
216595000369	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
216595000371	8 probable transmembrane helices predicted for PFLU0065 by TMHMM2.0 at aa 7-29, 75-97, 110-129, 144-166, 173-192, 245-267, 274-296 and 300-322
216595000372	PS00699 Nitrogenases component 1 alpha and beta subunits signature 1.
216595000373	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
216595000374	UbiA prenyltransferase family; Region: UbiA; pfam01040
216595000375	9 probable transmembrane helices predicted for PFLU0066 by TMHMM2.0 at aa 25-44, 49-71, 92-114, 119-139, 146-165, 169-191, 218-237, 242-264 and 277-296
216595000377	PS00943 UbiA prenyltransferase family signature.
216595000378	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
216595000379	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
216595000380	Cu(I) binding site [ion binding]; other site
216595000381	1 probable transmembrane helix predicted for PFLU0067 by TMHMM2.0 at aa 7-29
216595000383	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
216595000384	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
216595000386	PS00430 TonB-dependent receptor proteins signature 1.
216595000387	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595000388	dimer interface [polypeptide binding]; other site
216595000389	conserved gate region; other site
216595000390	ABC-ATPase subunit interface; other site
216595000392	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595000393	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
216595000394	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
216595000395	Walker A/P-loop; other site
216595000396	ATP binding site [chemical binding]; other site
216595000397	Q-loop/lid; other site
216595000398	ABC transporter signature motif; other site
216595000399	Walker B; other site
216595000400	D-loop; other site
216595000401	H-loop/switch region; other site
216595000402	NIL domain; Region: NIL; pfam09383
216595000404	PS00211 ABC transporters family signature.
216595000405	PS00017 ATP/GTP-binding site motif A (P-loop).
216595000406	hydroperoxidase II; Provisional; Region: katE; PRK11249
216595000407	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
216595000408	tetramer interface [polypeptide binding]; other site
216595000409	heme binding pocket [chemical binding]; other site
216595000410	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
216595000411	domain interactions; other site
216595000413	PS00438 Catalase proximal active site signature.
216595000414	PS00437 Catalase proximal heme-ligand signature.
216595000417	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595000418	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
216595000419	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
216595000420	ABC-ATPase subunit  interface; other site
216595000421	dimer interface [polypeptide binding]; other site
216595000422	putative PBP binding regions; other site
216595000424	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
216595000425	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216595000426	Walker A/P-loop; other site
216595000427	ATP binding site [chemical binding]; other site
216595000428	Q-loop/lid; other site
216595000429	ABC transporter signature motif; other site
216595000430	Walker B; other site
216595000431	D-loop; other site
216595000432	H-loop/switch region; other site
216595000434	PS00211 ABC transporters family signature.
216595000435	PS00017 ATP/GTP-binding site motif A (P-loop).
216595000436	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
216595000437	metal binding site 2 [ion binding]; metal-binding site
216595000438	putative DNA binding helix; other site
216595000439	metal binding site 1 [ion binding]; metal-binding site
216595000440	dimer interface [polypeptide binding]; other site
216595000441	structural Zn2+ binding site [ion binding]; other site
216595000442	PS00190 Cytochrome c family heme-binding site signature.
216595000443	ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531
216595000444	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
216595000445	metal binding site [ion binding]; metal-binding site
216595000448	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
216595000449	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
216595000450	putative active site [active]
216595000451	putative substrate binding site [chemical binding]; other site
216595000452	ATP binding site [chemical binding]; other site
216595000454	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
216595000455	DNA polymerase I; Provisional; Region: PRK05755
216595000456	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
216595000457	active site
216595000458	metal binding site 1 [ion binding]; metal-binding site
216595000459	putative 5' ssDNA interaction site; other site
216595000460	metal binding site 3; metal-binding site
216595000461	metal binding site 2 [ion binding]; metal-binding site
216595000462	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
216595000463	putative DNA binding site [nucleotide binding]; other site
216595000464	putative metal binding site [ion binding]; other site
216595000465	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
216595000466	active site
216595000467	catalytic site [active]
216595000468	substrate binding site [chemical binding]; other site
216595000469	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
216595000470	active site
216595000471	DNA binding site [nucleotide binding]
216595000472	catalytic site [active]
216595000477	PS00447 DNA polymerase family A signature.
216595000478	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
216595000479	G1 box; other site
216595000480	GTP/Mg2+ binding site [chemical binding]; other site
216595000481	Switch I region; other site
216595000482	G2 box; other site
216595000483	G3 box; other site
216595000484	Switch II region; other site
216595000485	G4 box; other site
216595000486	G5 box; other site
216595000488	PS00017 ATP/GTP-binding site motif A (P-loop).
216595000489	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
216595000490	PS00190 Cytochrome c family heme-binding site signature.
216595000491	Cytochrome c553 [Energy production and conversion]; Region: COG2863
216595000492	Cytochrome c; Region: Cytochrom_C; cl11414
216595000494	PS00190 Cytochrome c family heme-binding site signature.
216595000496	PS00190 Cytochrome c family heme-binding site signature.
216595000497	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
216595000498	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
216595000499	catalytic residues [active]
216595000500	hinge region; other site
216595000501	alpha helical domain; other site
216595000503	PS00194 Thioredoxin family active site.
216595000504	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
216595000505	putative catalytic site [active]
216595000506	putative metal binding site [ion binding]; other site
216595000507	putative phosphate binding site [ion binding]; other site
216595000509	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
216595000510	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216595000511	metal binding site [ion binding]; metal-binding site
216595000512	active site
216595000513	I-site; other site
216595000515	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
216595000516	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
216595000517	amidase catalytic site [active]
216595000518	Zn binding residues [ion binding]; other site
216595000519	substrate binding site [chemical binding]; other site
216595000520	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
216595000521	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595000524	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595000525	dimerization interface [polypeptide binding]; other site
216595000526	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
216595000527	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595000528	putative active site [active]
216595000529	heme pocket [chemical binding]; other site
216595000530	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595000531	dimer interface [polypeptide binding]; other site
216595000532	phosphorylation site [posttranslational modification]
216595000533	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595000534	ATP binding site [chemical binding]; other site
216595000535	Mg2+ binding site [ion binding]; other site
216595000536	G-X-G motif; other site
216595000541	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
216595000542	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595000543	active site
216595000544	phosphorylation site [posttranslational modification]
216595000545	intermolecular recognition site; other site
216595000546	dimerization interface [polypeptide binding]; other site
216595000547	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595000548	Walker A motif; other site
216595000549	ATP binding site [chemical binding]; other site
216595000550	Walker B motif; other site
216595000551	arginine finger; other site
216595000552	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
216595000554	PS00688 Sigma-54 interaction domain C-terminal part signature.
216595000556	PS00676 Sigma-54 interaction domain ATP-binding region B signature.
216595000557	PS00675 Sigma-54 interaction domain ATP-binding region A signature.
216595000560	2 probable transmembrane helices predicted for PFLU0090 by TMHMM2.0 at aa 2-24 and 29-48
216595000561	Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816
216595000563	glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283
216595000564	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
216595000565	8 probable transmembrane helices predicted for PFLU0093 by TMHMM2.0 at aa 7-29, 49-71, 84-106, 154-176, 205-227, 232-254, 320-342 and 362-384
216595000567	PS00713 Sodium:dicarboxylate symporter family signature 1.
216595000568	PS00714 Sodium:dicarboxylate symporter family signature 2.
216595000569	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
216595000570	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
216595000571	9 probable transmembrane helices predicted for PFLU0094 by TMHMM2.0 at aa 2-24, 39-61, 140-162, 172-194, 203-225, 230-252, 278-297, 357-379 and 386-408
216595000573	PS00012 Phosphopantetheine attachment site.
216595000575	Protein of unknown function (DUF330); Region: DUF330; cl01135
216595000576	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
216595000577	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595000578	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
216595000579	mce related protein; Region: MCE; pfam02470
216595000581	1 probable transmembrane helix predicted for PFLU0096 by TMHMM2.0 at aa 20-39
216595000582	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
216595000583	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216595000584	Walker A/P-loop; other site
216595000585	ATP binding site [chemical binding]; other site
216595000586	Q-loop/lid; other site
216595000587	ABC transporter signature motif; other site
216595000588	Walker B; other site
216595000589	D-loop; other site
216595000590	H-loop/switch region; other site
216595000591	PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.
216595000593	PS00211 ABC transporters family signature.
216595000594	PS00017 ATP/GTP-binding site motif A (P-loop).
216595000595	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
216595000596	Permease; Region: Permease; pfam02405
216595000598	Protein of unknown function (DUF2914); Region: DUF2914; pfam11141
216595000599	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
216595000600	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
216595000601	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
216595000602	1 probable transmembrane helix predicted for PFLU0100 by TMHMM2.0 at aa 433-455
216595000605	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
216595000606	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
216595000607	PhoU domain; Region: PhoU; pfam01895
216595000609	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
216595000611	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
216595000612	Citrate transporter; Region: CitMHS; pfam03600
216595000615	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
216595000616	PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.
216595000617	Protein of unknown function (DUF2388); Region: DUF2388; pfam09498
216595000618	Protein of unknown function (DUF2388); Region: DUF2388; pfam09498
216595000619	1 probable transmembrane helix predicted for PFLU0106 by TMHMM2.0 at aa 24-46
216595000620	Protein of unknown function (DUF2388); Region: DUF2388; pfam09498
216595000621	1 probable transmembrane helix predicted for PFLU0107 by TMHMM2.0 at aa 29-51
216595000622	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
216595000624	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
216595000625	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
216595000626	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
216595000628	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
216595000629	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
216595000631	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
216595000632	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
216595000633	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
216595000634	ligand binding site [chemical binding]; other site
216595000635	homodimer interface [polypeptide binding]; other site
216595000636	NAD(P) binding site [chemical binding]; other site
216595000637	trimer interface B [polypeptide binding]; other site
216595000638	trimer interface A [polypeptide binding]; other site
216595000641	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
216595000642	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595000643	The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481
216595000644	dimerization interface [polypeptide binding]; other site
216595000645	substrate binding pocket [chemical binding]; other site
216595000647	PS00430 TonB-dependent receptor proteins signature 1.
216595000649	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
216595000650	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
216595000651	FAD binding site [chemical binding]; other site
216595000652	substrate binding pocket [chemical binding]; other site
216595000653	catalytic base [active]
216595000657	PS00073 Acyl-CoA dehydrogenases signature 2.
216595000658	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
216595000659	CoA-transferase family III; Region: CoA_transf_3; pfam02515
216595000661	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
216595000662	Cache domain; Region: Cache_1; pfam02743
216595000663	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595000664	dimerization interface [polypeptide binding]; other site
216595000665	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
216595000666	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595000667	dimer interface [polypeptide binding]; other site
216595000668	putative CheW interface [polypeptide binding]; other site
216595000669	2 probable transmembrane helices predicted for PFLU0117 by TMHMM2.0 at aa 51-73 and 318-340
216595000674	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
216595000675	putative hydrophobic ligand binding site [chemical binding]; other site
216595000676	protein interface [polypeptide binding]; other site
216595000677	gate; other site
216595000678	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
216595000679	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
216595000680	AMP binding site [chemical binding]; other site
216595000681	acyl-activating enzyme (AAE) consensus motif; other site
216595000682	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
216595000683	thioester reductase domain; Region: Thioester-redct; TIGR01746
216595000684	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
216595000685	putative NAD(P) binding site [chemical binding]; other site
216595000686	active site
216595000687	putative substrate binding site [chemical binding]; other site
216595000690	PS00307 Legume lectins beta-chain signature.
216595000692	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
216595000693	Protein of unknown function (DUF3050); Region: DUF3050; pfam11251
216595000694	Transcriptional regulators [Transcription]; Region: GntR; COG1802
216595000695	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595000696	DNA-binding site [nucleotide binding]; DNA binding site
216595000697	FCD domain; Region: FCD; pfam07729
216595000700	PS00527 Ribosomal protein S14 signature.
216595000701	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
216595000702	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
216595000704	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
216595000705	NMT1-like family; Region: NMT1_2; pfam13379
216595000707	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
216595000708	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
216595000709	Walker A/P-loop; other site
216595000710	ATP binding site [chemical binding]; other site
216595000711	Q-loop/lid; other site
216595000712	ABC transporter signature motif; other site
216595000713	Walker B; other site
216595000714	D-loop; other site
216595000715	H-loop/switch region; other site
216595000717	PS00017 ATP/GTP-binding site motif A (P-loop).
216595000718	PS00211 ABC transporters family signature.
216595000719	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
216595000720	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595000721	putative PBP binding loops; other site
216595000722	ABC-ATPase subunit interface; other site
216595000724	6 probable transmembrane helices predicted for PFLU0126 by TMHMM2.0 at aa 86-108, 123-142, 147-169, 189-211, 216-238 and 248-267
216595000725	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
216595000726	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595000727	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595000728	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
216595000729	putative substrate binding pocket [chemical binding]; other site
216595000730	putative dimerization interface [polypeptide binding]; other site
216595000732	PS00044 Bacterial regulatory proteins, lysR family signature.
216595000734	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595000735	Major Facilitator Superfamily; Region: MFS_1; pfam07690
216595000736	14 probable transmembrane helices predicted for PFLU0129 by TMHMM2.0 at aa 21-43, 67-89, 96-115, 125-147, 152-174, 184-204, 217-239, 244-266, 287-309, 324-346, 353-375, 385-407, 414-436 and 482-499
216595000738	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
216595000739	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
216595000740	HlyD family secretion protein; Region: HlyD_3; pfam13437
216595000741	1 probable transmembrane helix predicted for PFLU0130 by TMHMM2.0 at aa 12-34
216595000743	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
216595000744	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595000747	Protein of unknown function (DUF3142); Region: DUF3142; pfam11340
216595000748	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729
216595000749	PS00017 ATP/GTP-binding site motif A (P-loop).
216595000750	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
216595000751	8 probable transmembrane helices predicted for PFLU0134 by TMHMM2.0 at aa 32-54, 100-122, 153-172, 192-214, 226-243, 288-310, 322-344 and 370-389
216595000753	Protein of unknown function (DUF2789); Region: DUF2789; pfam10982
216595000755	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
216595000756	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
216595000758	Fusaric acid resistance protein family; Region: FUSC; pfam04632
216595000759	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
216595000760	10 probable transmembrane helices predicted for PFLU0137 by TMHMM2.0 at aa 15-33, 61-83, 87-104, 111-130, 145-162, 367-389, 394-411, 418-440, 450-472 and 495-517
216595000762	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
216595000764	2 probable transmembrane helices predicted for PFLU0138 by TMHMM2.0 at aa 10-32 and 41-60
216595000765	p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559
216595000766	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
216595000767	HlyD family secretion protein; Region: HlyD_3; pfam13437
216595000768	1 probable transmembrane helix predicted for PFLU0139 by TMHMM2.0 at aa 7-29
216595000770	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
216595000771	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595000774	2 probable transmembrane helices predicted for PFLU0141 by TMHMM2.0 at aa 13-35 and 45-67
216595000775	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
216595000776	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
216595000778	1 probable transmembrane helix predicted for PFLU0142 by TMHMM2.0 at aa 5-27
216595000779	outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049
216595000780	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
216595000781	TPR motif; other site
216595000782	binding surface
216595000784	outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582
216595000785	N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964
216595000786	putative active site [active]
216595000787	putative metal binding site [ion binding]; other site
216595000788	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595000790	N-glycosyltransferase; Provisional; Region: PRK11204
216595000791	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
216595000792	DXD motif; other site
216595000793	5 probable transmembrane helices predicted for PFLU0145 by TMHMM2.0 at aa 13-35, 39-61, 327-349, 369-388 and 401-423
216595000795	PgaD-like protein; Region: PgaD; pfam13994
216595000796	2 probable transmembrane helices predicted for PFLU0146 by TMHMM2.0 at aa 13-35 and 55-77
216595000797	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
216595000798	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
216595000799	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
216595000802	haemagglutination activity domain; Region: Haemagg_act; pfam05860
216595000803	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
216595000804	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
216595000805	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
216595000806	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
216595000815	PS00017 ATP/GTP-binding site motif A (P-loop).
216595000819	PFI-1
216595000820	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
216595000822	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
216595000823	4 probable transmembrane helices predicted for PFLU0154 by TMHMM2.0 at aa 6-25, 30-52, 57-79 and 92-114
216595000824	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
216595000825	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
216595000826	Catalytic site [active]
216595000828	PS00760 Signal peptidases I lysine active site.
216595000829	PS00761 Signal peptidases I signature 3.
216595000830	3 probable transmembrane helices predicted for PFLU0155 by TMHMM2.0 at aa 21-40, 45-67 and 79-101
216595000831	RDD family; Region: RDD; pfam06271
216595000833	2 probable transmembrane helices predicted for PFLU0156 by TMHMM2.0 at aa 20-37 and 47-69
216595000834	RDD family; Region: RDD; pfam06271
216595000835	2 probable transmembrane helices predicted for PFLU0157 by TMHMM2.0 at aa 20-37 and 50-72
216595000836	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595000837	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595000838	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595000839	Curli production assembly/transport component CsgG; Region: CsgG; pfam03783
216595000841	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595000842	PS00017 ATP/GTP-binding site motif A (P-loop).
216595000843	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259
216595000844	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595000845	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4380
216595000847	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595000848	PS00296 Chaperonins cpn60 signature.
216595000849	von Willebrand factor; Region: vWF_A; pfam12450
216595000850	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
216595000851	VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465
216595000852	metal ion-dependent adhesion site (MIDAS); other site
216595000853	Domain of unknown function (DUF3520); Region: DUF3520; pfam12034
216595000855	PS00435 Peroxidases proximal heme-ligand signature.
216595000856	PS00584 pfkB family of carbohydrate kinases signature 2.
216595000857	RNA polymerase sigma factor; Provisional; Region: PRK12513
216595000858	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
216595000859	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
216595000860	DNA binding residues [nucleotide binding]
216595000863	SIR2-like domain; Region: SIR2_2; pfam13289
216595000864	HerA helicase [Replication, recombination, and repair]; Region: COG0433
216595000865	Domain of unknown function DUF87; Region: DUF87; pfam01935
216595000867	PS00017 ATP/GTP-binding site motif A (P-loop).
216595000868	chromosome segregation protein; Provisional; Region: PRK02224
216595000869	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
216595000870	active site
216595000871	metal binding site [ion binding]; metal-binding site
216595000872	interdomain interaction site; other site
216595000873	Domain of unknown function (DUF927); Region: DUF927; pfam06048
216595000874	PS00017 ATP/GTP-binding site motif A (P-loop).
216595000875	Protein of unknown function (DUF3077); Region: DUF3077; pfam11275
216595000876	1 probable transmembrane helix predicted for PFLU0177 by TMHMM2.0 at aa 52-74
216595000877	integrase; Provisional; Region: PRK09692
216595000878	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
216595000879	active site
216595000880	Int/Topo IB signature motif; other site
216595000882	succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241
216595000883	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
216595000884	tetramerization interface [polypeptide binding]; other site
216595000885	NAD(P) binding site [chemical binding]; other site
216595000886	catalytic residues [active]
216595000888	PS00687 Aldehyde dehydrogenases glutamic acid active site.
216595000889	PS00070 Aldehyde dehydrogenases cysteine active site.
216595000890	4-aminobutyrate aminotransferase; Validated; Region: PRK08088
216595000891	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
216595000892	inhibitor-cofactor binding pocket; inhibition site
216595000893	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595000894	catalytic residue [active]
216595000896	PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site.
216595000897	Response regulator receiver domain; Region: Response_reg; pfam00072
216595000898	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595000899	active site
216595000900	phosphorylation site [posttranslational modification]
216595000901	intermolecular recognition site; other site
216595000902	dimerization interface [polypeptide binding]; other site
216595000903	HDOD domain; Region: HDOD; pfam08668
216595000906	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595000907	PAS fold; Region: PAS_3; pfam08447
216595000908	putative active site [active]
216595000909	heme pocket [chemical binding]; other site
216595000910	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
216595000911	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216595000912	metal binding site [ion binding]; metal-binding site
216595000913	active site
216595000914	I-site; other site
216595000917	Fatty acid desaturase; Region: FA_desaturase; pfam00487
216595000918	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
216595000919	Di-iron ligands [ion binding]; other site
216595000920	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
216595000921	Transposase; Region: DDE_Tnp_ISL3; pfam01610
216595000923	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595000924	PAS domain; Region: PAS_9; pfam13426
216595000925	putative active site [active]
216595000926	heme pocket [chemical binding]; other site
216595000927	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
216595000928	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216595000929	metal binding site [ion binding]; metal-binding site
216595000930	active site
216595000931	I-site; other site
216595000932	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
216595000936	Uncharacterized small protein [Function unknown]; Region: COG5583
216595000937	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
216595000938	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
216595000940	PS00757 Prokaryotic sulfate-binding proteins signature 2.
216595000941	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
216595000942	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595000943	dimer interface [polypeptide binding]; other site
216595000944	conserved gate region; other site
216595000945	putative PBP binding loops; other site
216595000946	ABC-ATPase subunit interface; other site
216595000947	6 probable transmembrane helices predicted for PFLU0188 by TMHMM2.0 at aa 12-34, 63-85, 98-120, 135-157, 183-205 and 243-265
216595000949	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595000950	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
216595000951	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595000952	dimer interface [polypeptide binding]; other site
216595000953	conserved gate region; other site
216595000954	putative PBP binding loops; other site
216595000955	ABC-ATPase subunit interface; other site
216595000956	6 probable transmembrane helices predicted for PFLU0189 by TMHMM2.0 at aa 25-47, 72-94, 107-129, 144-166, 205-227 and 250-272
216595000958	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595000959	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
216595000960	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
216595000961	Walker A/P-loop; other site
216595000962	ATP binding site [chemical binding]; other site
216595000963	Q-loop/lid; other site
216595000964	ABC transporter signature motif; other site
216595000965	Walker B; other site
216595000966	D-loop; other site
216595000967	H-loop/switch region; other site
216595000968	TOBE-like domain; Region: TOBE_3; pfam12857
216595000970	PS00017 ATP/GTP-binding site motif A (P-loop).
216595000971	PS00211 ABC transporters family signature.
216595000972	Predicted membrane protein [Function unknown]; Region: COG4539
216595000974	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
216595000975	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
216595000976	ligand binding site [chemical binding]; other site
216595000977	flexible hinge region; other site
216595000978	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
216595000979	putative switch regulator; other site
216595000980	non-specific DNA interactions [nucleotide binding]; other site
216595000981	DNA binding site [nucleotide binding]
216595000982	sequence specific DNA binding site [nucleotide binding]; other site
216595000983	putative cAMP binding site [chemical binding]; other site
216595000986	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
216595000987	active site
216595000988	homotetramer interface [polypeptide binding]; other site
216595000990	PS00769 Transthyretin signature 2.
216595000991	Domain of unknown function (DUF336); Region: DUF336; cl01249
216595000994	PS00430 TonB-dependent receptor proteins signature 1.
216595000995	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
216595000996	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
216595000997	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595000999	Fatty acid desaturase; Region: FA_desaturase; pfam00487
216595001000	3 probable transmembrane helices predicted for PFLU0197 by TMHMM2.0 at aa 43-65, 189-211 and 231-253
216595001001	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
216595001002	Sulfatase; Region: Sulfatase; pfam00884
216595001004	PS00523 Sulfatases signature 1.
216595001005	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
216595001006	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
216595001007	Walker A/P-loop; other site
216595001008	ATP binding site [chemical binding]; other site
216595001009	Q-loop/lid; other site
216595001010	ABC transporter signature motif; other site
216595001011	Walker B; other site
216595001012	D-loop; other site
216595001013	H-loop/switch region; other site
216595001015	PS00211 ABC transporters family signature.
216595001016	PS00659 Glycosyl hydrolases family 5 signature.
216595001017	PS00017 ATP/GTP-binding site motif A (P-loop).
216595001018	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
216595001019	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
216595001020	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
216595001023	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
216595001024	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
216595001026	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595001027	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595001028	LysR substrate binding domain; Region: LysR_substrate; pfam03466
216595001029	dimerization interface [polypeptide binding]; other site
216595001032	PS00044 Bacterial regulatory proteins, lysR family signature.
216595001033	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
216595001034	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
216595001036	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
216595001037	Sulfatase; Region: Sulfatase; cl17466
216595001039	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595001040	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595001041	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
216595001042	dimerization interface [polypeptide binding]; other site
216595001044	PS00290 Immunoglobulins and major histocompatibility complex proteins signature.
216595001046	PS00044 Bacterial regulatory proteins, lysR family signature.
216595001047	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
216595001048	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216595001049	N-terminal plug; other site
216595001050	ligand-binding site [chemical binding]; other site
216595001053	PS01156 TonB-dependent receptor proteins signature 2.
216595001054	cyanate transporter; Region: CynX; TIGR00896
216595001055	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595001057	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595001058	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595001059	LysR substrate binding domain; Region: LysR_substrate; pfam03466
216595001060	dimerization interface [polypeptide binding]; other site
216595001062	PS00044 Bacterial regulatory proteins, lysR family signature.
216595001064	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
216595001065	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
216595001066	1 probable transmembrane helix predicted for PFLU0209 by TMHMM2.0 at aa 52-71
216595001068	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
216595001069	3 probable transmembrane helices predicted for PFLU0210 by TMHMM2.0 at aa 29-51, 139-161 and 181-203
216595001071	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
216595001072	TolR protein; Region: tolR; TIGR02801
216595001074	1 probable transmembrane helix predicted for PFLU0211 by TMHMM2.0 at aa 20-42
216595001075	Serine hydrolase; Region: Ser_hydrolase; pfam06821
216595001076	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
216595001078	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595001079	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
216595001080	Walker A motif; other site
216595001081	ATP binding site [chemical binding]; other site
216595001082	Walker B motif; other site
216595001084	PS00675 Sigma-54 interaction domain ATP-binding region A signature.
216595001085	PS00676 Sigma-54 interaction domain ATP-binding region B signature.
216595001086	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
216595001087	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
216595001089	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
216595001091	Predicted transcriptional regulator [Transcription]; Region: COG3905
216595001094	PS00397 Site-specific recombinases active site.
216595001096	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595001097	dimer interface [polypeptide binding]; other site
216595001098	conserved gate region; other site
216595001099	putative PBP binding loops; other site
216595001100	ABC-ATPase subunit interface; other site
216595001102	5 probable transmembrane helices predicted for PFLU0227 by TMHMM2.0 at aa 24-46, 71-93, 137-156, 161-183 and 188-210
216595001103	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595001104	PS00017 ATP/GTP-binding site motif A (P-loop).
216595001105	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
216595001106	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595001107	dimer interface [polypeptide binding]; other site
216595001108	conserved gate region; other site
216595001109	putative PBP binding loops; other site
216595001110	ABC-ATPase subunit interface; other site
216595001112	4 probable transmembrane helices predicted for PFLU0228 by TMHMM2.0 at aa 20-42, 55-77, 81-103 and 188-207
216595001113	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595001114	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
216595001115	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
216595001116	Walker A/P-loop; other site
216595001117	ATP binding site [chemical binding]; other site
216595001118	Q-loop/lid; other site
216595001119	ABC transporter signature motif; other site
216595001120	Walker B; other site
216595001121	D-loop; other site
216595001122	H-loop/switch region; other site
216595001124	PS00017 ATP/GTP-binding site motif A (P-loop).
216595001125	PS00211 ABC transporters family signature.
216595001126	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
216595001127	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595001128	substrate binding pocket [chemical binding]; other site
216595001129	membrane-bound complex binding site; other site
216595001130	hinge residues; other site
216595001131	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595001133	Predicted ATPase [General function prediction only]; Region: COG4637
216595001134	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216595001135	Walker A/P-loop; other site
216595001136	ATP binding site [chemical binding]; other site
216595001138	PS00017 ATP/GTP-binding site motif A (P-loop).
216595001139	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
216595001140	HlyD family secretion protein; Region: HlyD_3; pfam13437
216595001141	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595001143	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
216595001144	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
216595001145	putative membrane fusion protein; Region: TIGR02828
216595001146	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595001148	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
216595001150	11 probable transmembrane helices predicted for PFLU0234 by TMHMM2.0 at aa 15-37, 335-357, 361-380, 392-414, 434-456, 463-485, 521-543, 854-876, 881-900, 907-929 and 985-1007
216595001151	Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308
216595001152	Methyltransferase domain; Region: Methyltransf_23; pfam13489
216595001153	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595001154	S-adenosylmethionine binding site [chemical binding]; other site
216595001156	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595001157	dimer interface [polypeptide binding]; other site
216595001158	conserved gate region; other site
216595001159	ABC-ATPase subunit interface; other site
216595001161	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595001162	PS00012 Phosphopantetheine attachment site.
216595001163	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
216595001164	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
216595001165	Walker A/P-loop; other site
216595001166	ATP binding site [chemical binding]; other site
216595001167	Q-loop/lid; other site
216595001168	ABC transporter signature motif; other site
216595001169	Walker B; other site
216595001170	D-loop; other site
216595001171	H-loop/switch region; other site
216595001172	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
216595001174	PS00211 ABC transporters family signature.
216595001175	PS00017 ATP/GTP-binding site motif A (P-loop).
216595001176	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
216595001178	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
216595001179	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
216595001180	non-prolyl cis peptide bond; other site
216595001181	active site
216595001182	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
216595001183	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
216595001184	Flavin binding site [chemical binding]; other site
216595001187	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
216595001188	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
216595001189	Flavin binding site [chemical binding]; other site
216595001192	putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264
216595001193	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
216595001194	Walker A/P-loop; other site
216595001195	ATP binding site [chemical binding]; other site
216595001196	Q-loop/lid; other site
216595001197	ABC transporter signature motif; other site
216595001198	Walker B; other site
216595001199	D-loop; other site
216595001200	H-loop/switch region; other site
216595001202	PS00211 ABC transporters family signature.
216595001203	PS00017 ATP/GTP-binding site motif A (P-loop).
216595001204	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595001205	dimer interface [polypeptide binding]; other site
216595001206	conserved gate region; other site
216595001207	putative PBP binding loops; other site
216595001208	ABC-ATPase subunit interface; other site
216595001210	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595001211	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
216595001212	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595001213	substrate binding pocket [chemical binding]; other site
216595001214	membrane-bound complex binding site; other site
216595001215	hinge residues; other site
216595001217	PS01039 Bacterial extracellular solute-binding proteins, family 3 signature.
216595001218	D-cysteine desulfhydrase; Validated; Region: PRK03910
216595001219	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
216595001220	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
216595001221	catalytic residue [active]
216595001223	serine O-acetyltransferase; Region: cysE; TIGR01172
216595001224	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
216595001225	trimer interface [polypeptide binding]; other site
216595001226	active site
216595001227	substrate binding site [chemical binding]; other site
216595001228	CoA binding site [chemical binding]; other site
216595001233	BCCT family transporter; Region: BCCT; cl00569
216595001235	12 probable transmembrane helices predicted for PFLU0249 by TMHMM2.0 at aa 55-74, 94-116, 129-151, 181-203, 224-246, 266-288, 301-323, 353-375, 388-407, 448-470, 491-510 and 516-535
216595001236	PS01303 BCCT family of transporters signature.
216595001237	PS00639 Eukaryotic thiol (cysteine) proteases histidine active site.
216595001238	outer membrane porin, OprD family; Region: OprD; pfam03573
216595001240	PS00047 Histone H4 signature.
216595001241	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
216595001242	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
216595001243	active site
216595001244	catalytic tetrad [active]
216595001246	taurine dioxygenase; Reviewed; Region: tauD; PRK09553
216595001247	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
216595001249	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
216595001250	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595001251	dimer interface [polypeptide binding]; other site
216595001252	conserved gate region; other site
216595001253	putative PBP binding loops; other site
216595001254	ABC-ATPase subunit interface; other site
216595001256	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595001257	taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248
216595001258	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
216595001259	Walker A/P-loop; other site
216595001260	ATP binding site [chemical binding]; other site
216595001261	Q-loop/lid; other site
216595001262	ABC transporter signature motif; other site
216595001263	Walker B; other site
216595001264	D-loop; other site
216595001265	H-loop/switch region; other site
216595001267	PS00211 ABC transporters family signature.
216595001268	PS00017 ATP/GTP-binding site motif A (P-loop).
216595001269	taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729
216595001270	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595001271	substrate binding pocket [chemical binding]; other site
216595001272	membrane-bound complex binding site; other site
216595001273	hinge residues; other site
216595001275	glutamate--cysteine ligase; Provisional; Region: PRK02107
216595001277	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
216595001278	CoenzymeA binding site [chemical binding]; other site
216595001279	subunit interaction site [polypeptide binding]; other site
216595001280	PHB binding site; other site
216595001281	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
216595001283	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
216595001284	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
216595001285	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
216595001286	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
216595001287	RNA binding site [nucleotide binding]; other site
216595001289	osmolarity response regulator; Provisional; Region: ompR; PRK09468
216595001290	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595001291	active site
216595001292	phosphorylation site [posttranslational modification]
216595001293	intermolecular recognition site; other site
216595001294	dimerization interface [polypeptide binding]; other site
216595001295	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216595001296	DNA binding site [nucleotide binding]
216595001299	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
216595001300	HAMP domain; Region: HAMP; pfam00672
216595001301	dimerization interface [polypeptide binding]; other site
216595001302	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595001303	ATP binding site [chemical binding]; other site
216595001304	Mg2+ binding site [ion binding]; other site
216595001305	G-X-G motif; other site
216595001306	2 probable transmembrane helices predicted for PFLU0260 by TMHMM2.0 at aa 15-37 and 145-167
216595001310	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
216595001311	RimK-like ATP-grasp domain; Region: RimK; pfam08443
216595001313	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
216595001315	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
216595001317	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
216595001318	RNA binding surface [nucleotide binding]; other site
216595001320	PAP2 superfamily; Region: PAP2; pfam01569
216595001321	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
216595001322	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
216595001323	dimerization interface [polypeptide binding]; other site
216595001324	domain crossover interface; other site
216595001325	redox-dependent activation switch; other site
216595001327	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
216595001328	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
216595001329	active site
216595001330	substrate-binding site [chemical binding]; other site
216595001331	metal-binding site [ion binding]
216595001332	ATP binding site [chemical binding]; other site
216595001334	PS00017 ATP/GTP-binding site motif A (P-loop).
216595001335	Protein of unknown function (DUF1493); Region: DUF1493; pfam07377
216595001336	Fic/DOC family; Region: Fic; cl00960
216595001338	TPR repeat; Region: TPR_11; pfam13414
216595001339	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
216595001340	binding surface
216595001341	TPR motif; other site
216595001345	DEAD-like helicases superfamily; Region: DEXDc; smart00487
216595001346	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
216595001347	ATP binding site [chemical binding]; other site
216595001348	putative Mg++ binding site [ion binding]; other site
216595001349	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
216595001350	nucleotide binding region [chemical binding]; other site
216595001351	ATP-binding site [chemical binding]; other site
216595001353	PS00690 DEAH-box subfamily ATP-dependent helicases signature.
216595001355	PS00190 Cytochrome c family heme-binding site signature.
216595001356	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
216595001357	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
216595001358	active site
216595001363	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
216595001364	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
216595001365	putative molybdopterin cofactor binding site [chemical binding]; other site
216595001366	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
216595001367	putative molybdopterin cofactor binding site; other site
216595001371	Uncharacterized protein required for formate dehydrogenase activity [Energy production and conversion]; Region: FdhD; COG1526
216595001373	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595001374	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595001375	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
216595001376	dimerization interface [polypeptide binding]; other site
216595001379	PS00044 Bacterial regulatory proteins, lysR family signature.
216595001380	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
216595001381	BON domain; Region: BON; pfam04972
216595001382	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
216595001385	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
216595001386	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216595001387	motif II; other site
216595001389	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
216595001390	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
216595001391	dimer interface [polypeptide binding]; other site
216595001392	ADP-ribose binding site [chemical binding]; other site
216595001393	active site
216595001394	nudix motif; other site
216595001395	metal binding site [ion binding]; metal-binding site
216595001397	PS00893 mutT domain signature.
216595001398	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
216595001399	active site
216595001401	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500
216595001402	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
216595001403	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595001404	active site
216595001405	phosphorylation site [posttranslational modification]
216595001406	intermolecular recognition site; other site
216595001407	dimerization interface [polypeptide binding]; other site
216595001408	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595001409	Walker A motif; other site
216595001410	ATP binding site [chemical binding]; other site
216595001411	Walker B motif; other site
216595001412	arginine finger; other site
216595001413	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
216595001415	PS00688 Sigma-54 interaction domain C-terminal part signature.
216595001417	PS00676 Sigma-54 interaction domain ATP-binding region B signature.
216595001418	PS00675 Sigma-54 interaction domain ATP-binding region A signature.
216595001420	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
216595001421	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595001422	dimer interface [polypeptide binding]; other site
216595001423	phosphorylation site [posttranslational modification]
216595001424	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595001425	ATP binding site [chemical binding]; other site
216595001426	G-X-G motif; other site
216595001429	1 probable transmembrane helix predicted for PFLU0287 by TMHMM2.0 at aa 281-303
216595001430	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
216595001431	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
216595001432	NADP binding site [chemical binding]; other site
216595001433	active site
216595001434	putative substrate binding site [chemical binding]; other site
216595001436	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221
216595001438	PS00017 ATP/GTP-binding site motif A (P-loop).
216595001439	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
216595001440	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
216595001441	substrate binding site; other site
216595001442	tetramer interface; other site
216595001444	dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084
216595001445	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
216595001446	NAD binding site [chemical binding]; other site
216595001447	substrate binding site [chemical binding]; other site
216595001448	homodimer interface [polypeptide binding]; other site
216595001449	active site
216595001451	PS00061 Short-chain dehydrogenases/reductases family signature.
216595001452	hypothetical protein; Provisional; Region: PRK06149
216595001453	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
216595001454	active site
216595001455	substrate binding site [chemical binding]; other site
216595001456	ATP binding site [chemical binding]; other site
216595001457	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
216595001458	inhibitor-cofactor binding pocket; inhibition site
216595001459	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595001460	catalytic residue [active]
216595001463	agmatine deiminase; Provisional; Region: PRK13551
216595001464	agmatine deiminase; Region: agmatine_aguA; TIGR03380
216595001466	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
216595001467	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216595001468	N-terminal plug; other site
216595001469	ligand-binding site [chemical binding]; other site
216595001472	outer membrane porin, OprD family; Region: OprD; pfam03573
216595001474	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595001475	cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371
216595001476	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
216595001477	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
216595001479	cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030
216595001480	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
216595001481	DXD motif; other site
216595001482	PilZ domain; Region: PilZ; pfam07238
216595001483	8 probable transmembrane helices predicted for PFLU0301 by TMHMM2.0 at aa 36-55, 59-76, 83-101, 116-138, 414-436, 440-462, 524-546 and 551-573
216595001486	cellulose synthase regulator protein; Provisional; Region: PRK11114
216595001488	1 probable transmembrane helix predicted for PFLU0302 by TMHMM2.0 at aa 724-746
216595001489	endo-1,4-D-glucanase; Provisional; Region: PRK11097
216595001491	PS00812 Glycosyl hydrolases family 8 signature.
216595001492	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
216595001493	binding surface
216595001494	TPR repeat; Region: TPR_11; pfam13414
216595001495	TPR motif; other site
216595001496	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
216595001497	binding surface
216595001498	Tetratricopeptide repeat; Region: TPR_16; pfam13432
216595001499	TPR motif; other site
216595001500	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
216595001501	binding surface
216595001502	TPR motif; other site
216595001503	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
216595001504	TPR motif; other site
216595001505	binding surface
216595001506	TPR repeat; Region: TPR_11; pfam13414
216595001507	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
216595001513	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
216595001514	catalytic triad [active]
216595001515	Alginate O-acetyl transferase AlgF; Region: AlgF; pfam11182
216595001516	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
216595001517	9 probable transmembrane helices predicted for PFLU0307 by TMHMM2.0 at aa 2-23, 43-65, 78-100, 120-138, 151-170, 239-261, 351-373, 403-425 and 438-460
216595001519	1 probable transmembrane helix predicted for PFLU0308 by TMHMM2.0 at aa 20-41
216595001520	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595001521	cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371
216595001522	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
216595001523	P-loop; other site
216595001524	Magnesium ion binding site [ion binding]; other site
216595001525	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
216595001526	Methyltransferase domain; Region: Methyltransf_32; pfam13679
216595001527	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
216595001528	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595001529	dimer interface [polypeptide binding]; other site
216595001530	conserved gate region; other site
216595001531	putative PBP binding loops; other site
216595001532	ABC-ATPase subunit interface; other site
216595001534	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595001535	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
216595001536	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595001537	dimer interface [polypeptide binding]; other site
216595001538	conserved gate region; other site
216595001539	putative PBP binding loops; other site
216595001540	ABC-ATPase subunit interface; other site
216595001542	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595001543	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
216595001544	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595001545	substrate binding pocket [chemical binding]; other site
216595001546	membrane-bound complex binding site; other site
216595001547	hinge residues; other site
216595001549	1 probable transmembrane helix predicted for PFLU0313 by TMHMM2.0 at aa 7-26
216595001550	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
216595001551	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
216595001552	Walker A/P-loop; other site
216595001553	ATP binding site [chemical binding]; other site
216595001554	Q-loop/lid; other site
216595001555	ABC transporter signature motif; other site
216595001556	Walker B; other site
216595001557	D-loop; other site
216595001558	H-loop/switch region; other site
216595001560	PS00211 ABC transporters family signature.
216595001561	PS00017 ATP/GTP-binding site motif A (P-loop).
216595001562	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
216595001563	Spore germination protein; Region: Spore_permease; cl17796
216595001565	12 probable transmembrane helices predicted for PFLU0315 by TMHMM2.0 at aa 74-96, 101-120, 141-163, 178-200, 212-234, 254-276, 296-318, 342-364, 390-409, 413-435, 456-478 and 483-505
216595001566	PS00639 Eukaryotic thiol (cysteine) proteases histidine active site.
216595001567	PS00218 Amino acid permeases signature.
216595001568	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
216595001569	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
216595001570	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
216595001572	PS00120 Lipases, serine active site.
216595001573	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
216595001574	8 probable transmembrane helices predicted for PFLU0318 by TMHMM2.0 at aa 13-32, 37-56, 68-87, 97-119, 126-148, 163-185, 197-219 and 232-254
216595001575	PS00044 Bacterial regulatory proteins, lysR family signature.
216595001577	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
216595001578	11 probable transmembrane helices predicted for PFLU0319 by TMHMM2.0 at aa 7-26, 85-107, 134-151, 166-188, 201-220, 257-276, 289-308, 313-332, 344-363, 373-395 and 402-424
216595001579	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595001580	oxidative damage protection protein; Provisional; Region: PRK05408
216595001582	adenine DNA glycosylase; Provisional; Region: PRK10880
216595001583	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
216595001584	minor groove reading motif; other site
216595001585	helix-hairpin-helix signature motif; other site
216595001586	substrate binding pocket [chemical binding]; other site
216595001587	active site
216595001588	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
216595001589	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
216595001590	DNA binding and oxoG recognition site [nucleotide binding]
216595001593	AsmA family; Region: AsmA; pfam05170
216595001594	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
216595001596	PS00017 ATP/GTP-binding site motif A (P-loop).
216595001597	1 probable transmembrane helix predicted for PFLU0324 by TMHMM2.0 at aa 13-35
216595001598	oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259
216595001599	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595001600	13 probable transmembrane helices predicted for PFLU0325 by TMHMM2.0 at aa 31-53, 91-113, 122-141, 145-167, 187-209, 214-236, 280-302, 329-351, 363-385, 389-411, 423-445, 460-482 and 521-543
216595001602	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
216595001603	putative active site pocket [active]
216595001604	4-fold oligomerization interface [polypeptide binding]; other site
216595001605	metal binding residues [ion binding]; metal-binding site
216595001606	3-fold/trimer interface [polypeptide binding]; other site
216595001608	PS00954 Imidazoleglycerol-phosphate dehydratase signature 1.
216595001609	PS00955 Imidazoleglycerol-phosphate dehydratase signature 2.
216595001610	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
216595001611	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
216595001612	putative active site [active]
216595001613	oxyanion strand; other site
216595001614	catalytic triad [active]
216595001616	PS00442 Glutamine amidotransferases class-I active site.
216595001617	Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932
216595001618	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
216595001619	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
216595001620	catalytic residues [active]
216595001622	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
216595001623	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
216595001624	substrate binding site [chemical binding]; other site
216595001625	glutamase interaction surface [polypeptide binding]; other site
216595001627	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595001628	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
216595001629	substrate binding pocket [chemical binding]; other site
216595001630	membrane-bound complex binding site; other site
216595001631	hinge residues; other site
216595001632	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595001633	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
216595001634	NodB motif; other site
216595001635	putative active site [active]
216595001636	putative catalytic site [active]
216595001637	Zn binding site [ion binding]; other site
216595001639	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
216595001640	C-terminal peptidase (prc); Region: prc; TIGR00225
216595001641	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
216595001642	protein binding site [polypeptide binding]; other site
216595001643	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
216595001644	Catalytic dyad [active]
216595001647	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
216595001648	Peptidase family M23; Region: Peptidase_M23; pfam01551
216595001650	phosphoglyceromutase; Provisional; Region: PRK05434
216595001651	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307
216595001654	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
216595001655	active site residue [active]
216595001656	1 probable transmembrane helix predicted for PFLU0338 by TMHMM2.0 at aa 7-29
216595001658	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
216595001659	GSH binding site [chemical binding]; other site
216595001660	catalytic residues [active]
216595001662	PS00194 Thioredoxin family active site.
216595001663	PS00195 Glutaredoxin active site.
216595001664	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
216595001665	SecA binding site; other site
216595001666	Preprotein binding site; other site
216595001668	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
216595001670	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
216595001671	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595001672	active site
216595001673	phosphorylation site [posttranslational modification]
216595001674	intermolecular recognition site; other site
216595001675	dimerization interface [polypeptide binding]; other site
216595001676	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595001677	Walker A motif; other site
216595001678	ATP binding site [chemical binding]; other site
216595001679	Walker B motif; other site
216595001680	arginine finger; other site
216595001681	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
216595001683	PS00688 Sigma-54 interaction domain C-terminal part signature.
216595001685	PS00676 Sigma-54 interaction domain ATP-binding region B signature.
216595001686	PS00675 Sigma-54 interaction domain ATP-binding region A signature.
216595001688	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
216595001689	PAS domain; Region: PAS; smart00091
216595001690	putative active site [active]
216595001691	heme pocket [chemical binding]; other site
216595001692	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595001693	dimer interface [polypeptide binding]; other site
216595001694	phosphorylation site [posttranslational modification]
216595001695	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595001696	ATP binding site [chemical binding]; other site
216595001697	Mg2+ binding site [ion binding]; other site
216595001698	G-X-G motif; other site
216595001702	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595001703	Cupin domain; Region: Cupin_2; pfam07883
216595001705	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595001706	chorismate mutase; Provisional; Region: PRK09269
216595001707	Chorismate mutase type II; Region: CM_2; cl00693
216595001709	glutamine synthetase; Provisional; Region: glnA; PRK09469
216595001710	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
216595001711	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
216595001712	PS00182 Glutamine synthetase class-I adenylation site.
216595001714	PS00181 Glutamine synthetase putative ATP-binding region signature.
216595001716	PS00180 Glutamine synthetase signature 1.
216595001717	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
216595001718	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
216595001719	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
216595001720	Ligand Binding Site [chemical binding]; other site
216595001721	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
216595001722	active site residue [active]
216595001725	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
216595001726	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
216595001727	G1 box; other site
216595001728	putative GEF interaction site [polypeptide binding]; other site
216595001729	GTP/Mg2+ binding site [chemical binding]; other site
216595001730	Switch I region; other site
216595001731	G2 box; other site
216595001732	G3 box; other site
216595001733	Switch II region; other site
216595001734	G4 box; other site
216595001735	G5 box; other site
216595001736	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
216595001737	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
216595001739	PS00017 ATP/GTP-binding site motif A (P-loop).
216595001740	PS00301 GTP-binding elongation factors signature.
216595001743	Flagellin N-methylase; Region: FliB; pfam03692
216595001745	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
216595001746	homodimer interface [polypeptide binding]; other site
216595001747	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
216595001748	active site pocket [active]
216595001750	PS00102 Phosphorylase pyridoxal-phosphate attachment site.
216595001751	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
216595001752	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
216595001753	32 probable transmembrane helices predicted for PFLU0353 by TMHMM2.0 at aa 156-178, 193-210, 217-236, 246-263, 268-290, 294-313, 318-340, 344-366, 421-443, 447-469, 496-513, 523-542, 563-580, 584-601, 608-630, 640-662, 675-697, 701-718, 725-747, 757-779, 799-821, 826-845, 852-874, 878-897, 910-932, 942-964, 977-994, 1007-1029, 1042-1061, 1081-1103, 1110-1129 and 1134-1156
216595001754	Protein of unknown function (DUF3999); Region: DUF3999; pfam13163
216595001755	1 probable transmembrane helix predicted for PFLU0354 by TMHMM2.0 at aa 423-445
216595001756	fructose-1,6-bisphosphatase family protein; Region: PLN02628
216595001757	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
216595001758	AMP binding site [chemical binding]; other site
216595001759	metal binding site [ion binding]; metal-binding site
216595001760	active site
216595001762	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
216595001763	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595001764	Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040
216595001765	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
216595001766	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
216595001767	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595001768	PS00213 Lipocalin signature.
216595001770	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
216595001771	Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313
216595001772	active site
216595001774	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
216595001775	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595001776	DNA-binding site [nucleotide binding]; DNA binding site
216595001777	UTRA domain; Region: UTRA; pfam07702
216595001779	PS00043 Bacterial regulatory proteins, gntR family signature.
216595001781	HutD; Region: HutD; pfam05962
216595001783	urocanate hydratase; Provisional; Region: PRK05414
216595001785	PS01233 Urocanase active site.
216595001786	Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457
216595001787	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
216595001788	Na binding site [ion binding]; other site
216595001790	13 probable transmembrane helices predicted for PFLU0362 by TMHMM2.0 at aa 31-53, 58-80, 95-117, 138-155, 160-182, 195-214, 234-256, 269-291, 296-315, 327-349, 354-376, 397-416 and 426-448
216595001791	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
216595001792	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
216595001794	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595001795	dimer interface [polypeptide binding]; other site
216595001796	conserved gate region; other site
216595001797	putative PBP binding loops; other site
216595001798	ABC-ATPase subunit interface; other site
216595001799	4 probable transmembrane helices predicted for PFLU0364 by TMHMM2.0 at aa 35-57, 70-89, 96-118 and 139-161
216595001801	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
216595001802	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
216595001803	Walker A/P-loop; other site
216595001804	ATP binding site [chemical binding]; other site
216595001805	Q-loop/lid; other site
216595001806	ABC transporter signature motif; other site
216595001807	Walker B; other site
216595001808	D-loop; other site
216595001809	H-loop/switch region; other site
216595001810	PS00017 ATP/GTP-binding site motif A (P-loop).
216595001812	PS00017 ATP/GTP-binding site motif A (P-loop).
216595001813	PS00211 ABC transporters family signature.
216595001814	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
216595001815	active sites [active]
216595001816	tetramer interface [polypeptide binding]; other site
216595001818	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595001819	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
216595001820	active sites [active]
216595001821	tetramer interface [polypeptide binding]; other site
216595001823	PS00488 Phenylalanine and histidine ammonia-lyases signature.
216595001824	PS00213 Lipocalin signature.
216595001825	putative proline-specific permease; Provisional; Region: proY; PRK10580
216595001827	12 probable transmembrane helices predicted for PFLU0368 by TMHMM2.0 at aa 19-41, 45-64, 88-110, 125-147, 154-176, 201-223, 244-266, 281-303, 333-355, 359-381, 402-424 and 428-450
216595001828	PS00218 Amino acid permeases signature.
216595001829	imidazolonepropionase; Validated; Region: PRK09356
216595001830	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
216595001831	active site
216595001833	N-formylglutamate amidohydrolase; Region: FGase; cl01522
216595001835	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
216595001836	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
216595001838	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
216595001839	putative active site [active]
216595001840	dimerization interface [polypeptide binding]; other site
216595001841	putative tRNAtyr binding site [nucleotide binding]; other site
216595001843	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
216595001844	Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433
216595001846	Protein of unknown function (DUF1379); Region: DUF1379; pfam07126
216595001847	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
216595001848	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
216595001849	Ligand binding site; other site
216595001850	DXD motif; other site
216595001851	6 probable transmembrane helices predicted for PFLU0374 by TMHMM2.0 at aa 143-160, 199-221, 522-544, 572-594, 607-629 and 683-705
216595001853	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
216595001854	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595001855	substrate binding pocket [chemical binding]; other site
216595001856	membrane-bound complex binding site; other site
216595001857	hinge residues; other site
216595001858	PS00430 TonB-dependent receptor proteins signature 1.
216595001860	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
216595001861	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595001862	substrate binding pocket [chemical binding]; other site
216595001863	membrane-bound complex binding site; other site
216595001864	hinge residues; other site
216595001865	1 probable transmembrane helix predicted for PFLU0376 by TMHMM2.0 at aa 7-28
216595001867	PS01039 Bacterial extracellular solute-binding proteins, family 3 signature.
216595001868	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
216595001869	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595001870	dimer interface [polypeptide binding]; other site
216595001871	conserved gate region; other site
216595001872	putative PBP binding loops; other site
216595001873	ABC-ATPase subunit interface; other site
216595001874	5 probable transmembrane helices predicted for PFLU0377 by TMHMM2.0 at aa 12-34, 118-140, 161-180, 190-212 and 279-301
216595001876	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595001877	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
216595001878	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
216595001879	Walker A/P-loop; other site
216595001880	ATP binding site [chemical binding]; other site
216595001881	Q-loop/lid; other site
216595001882	ABC transporter signature motif; other site
216595001883	Walker B; other site
216595001884	D-loop; other site
216595001885	H-loop/switch region; other site
216595001887	PS00017 ATP/GTP-binding site motif A (P-loop).
216595001888	PS00211 ABC transporters family signature.
216595001889	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595001890	dimerization interface [polypeptide binding]; other site
216595001891	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
216595001892	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595001893	dimer interface [polypeptide binding]; other site
216595001894	putative CheW interface [polypeptide binding]; other site
216595001897	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595001898	dimerization interface [polypeptide binding]; other site
216595001899	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
216595001900	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595001901	dimer interface [polypeptide binding]; other site
216595001902	putative CheW interface [polypeptide binding]; other site
216595001905	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
216595001907	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
216595001909	PS01218 Uncharacterized protein family UPF0032 signature.
216595001910	sec-independent translocase; Provisional; Region: tatB; PRK00404
216595001911	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
216595001913	twin arginine translocase protein A; Provisional; Region: tatA; PRK00442
216595001914	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
216595001916	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
216595001917	metal binding site [ion binding]; metal-binding site
216595001919	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
216595001921	ABC1 family; Region: ABC1; cl17513
216595001922	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
216595001924	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
216595001925	SCP-2 sterol transfer family; Region: SCP2; pfam02036
216595001927	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
216595001928	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595001929	S-adenosylmethionine binding site [chemical binding]; other site
216595001931	PS01184 ubiE/COQ5 methyltransferase family signature 2.
216595001932	PS01183 ubiE/COQ5 methyltransferase family signature 1.
216595001933	Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865
216595001934	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597
216595001936	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597
216595001938	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
216595001939	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216595001940	Bacterial transcriptional repressor; Region: TetR; pfam13972
216595001942	poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839
216595001943	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
216595001946	poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240
216595001947	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
216595001949	poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839
216595001950	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
216595001953	PS00017 ATP/GTP-binding site motif A (P-loop).
216595001954	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
216595001956	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
216595001957	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595001958	Walker A motif; other site
216595001959	ATP binding site [chemical binding]; other site
216595001960	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
216595001961	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
216595001964	PS00017 ATP/GTP-binding site motif A (P-loop).
216595001965	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
216595001966	active site
216595001967	HslU subunit interaction site [polypeptide binding]; other site
216595001969	Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087
216595001970	Sporulation related domain; Region: SPOR; pfam05036
216595001972	1 probable transmembrane helix predicted for PFLU0400 by TMHMM2.0 at aa 24-43
216595001973	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
216595001974	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
216595001975	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
216595001976	active site
216595001977	HIGH motif; other site
216595001978	KMSK motif region; other site
216595001979	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
216595001980	tRNA binding surface [nucleotide binding]; other site
216595001981	anticodon binding site; other site
216595001984	PS00178 Aminoacyl-transfer RNA synthetases class-I signature.
216595001986	primosome assembly protein PriA; Validated; Region: PRK05580
216595001987	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
216595001988	ATP binding site [chemical binding]; other site
216595001989	putative Mg++ binding site [ion binding]; other site
216595001990	helicase superfamily c-terminal domain; Region: HELICc; smart00490
216595001991	ATP-binding site [chemical binding]; other site
216595001994	PS00017 ATP/GTP-binding site motif A (P-loop).
216595001995	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
216595001997	PS00190 Cytochrome c family heme-binding site signature.
216595001998	PS01143 Ribosomal protein L31 signature.
216595001999	Staphylococcal nuclease homologues; Region: SNc; smart00318
216595002000	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
216595002001	Catalytic site; other site
216595002003	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
216595002004	Malic enzyme, N-terminal domain; Region: malic; pfam00390
216595002005	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
216595002006	putative NAD(P) binding site [chemical binding]; other site
216595002008	PS00331 Malic enzymes signature.
216595002010	PS00017 ATP/GTP-binding site motif A (P-loop).
216595002012	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
216595002013	Transglycosylase; Region: Transgly; pfam00912
216595002014	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
216595002017	1 probable transmembrane helix predicted for PFLU0406 by TMHMM2.0 at aa 7-29
216595002018	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
216595002019	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
216595002021	1 probable transmembrane helix predicted for PFLU0408 by TMHMM2.0 at aa 30-49
216595002022	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595002023	Pilus assembly protein, PilO; Region: PilO; pfam04350
216595002024	Pilus assembly protein, PilP; Region: PilP; pfam04351
216595002030	PS00875 Bacterial type II secretion system protein D signature.
216595002031	shikimate kinase; Reviewed; Region: aroK; PRK00131
216595002032	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
216595002033	ADP binding site [chemical binding]; other site
216595002034	magnesium binding site [ion binding]; other site
216595002035	putative shikimate binding site; other site
216595002036	PS00017 ATP/GTP-binding site motif A (P-loop).
216595002038	PS01128 Shikimate kinase signature.
216595002039	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
216595002040	active site
216595002041	dimer interface [polypeptide binding]; other site
216595002042	metal binding site [ion binding]; metal-binding site
216595002044	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
216595002045	Sporulation related domain; Region: SPOR; pfam05036
216595002046	PS00017 ATP/GTP-binding site motif A (P-loop).
216595002047	1 probable transmembrane helix predicted for PFLU0413 by TMHMM2.0 at aa 264-281
216595002049	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
216595002050	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
216595002051	active site
216595002052	dimer interface [polypeptide binding]; other site
216595002053	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
216595002054	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
216595002055	active site
216595002056	FMN binding site [chemical binding]; other site
216595002057	substrate binding site [chemical binding]; other site
216595002058	3Fe-4S cluster binding site [ion binding]; other site
216595002059	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
216595002060	domain interface; other site
216595002062	PS00017 ATP/GTP-binding site motif A (P-loop).
216595002066	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
216595002067	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
216595002070	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
216595002071	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
216595002072	substrate binding site [chemical binding]; other site
216595002073	active site
216595002075	PS00906 Uroporphyrinogen decarboxylase signature 1.
216595002076	PS00907 Uroporphyrinogen decarboxylase signature 2.
216595002077	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595002078	Major Facilitator Superfamily; Region: MFS_1; pfam07690
216595002079	putative substrate translocation pore; other site
216595002081	PS00216 Sugar transport proteins signature 1.
216595002082	PS00216 Sugar transport proteins signature 1.
216595002083	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
216595002084	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595002085	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
216595002086	dimerization interface [polypeptide binding]; other site
216595002087	substrate binding pocket [chemical binding]; other site
216595002089	PS00044 Bacterial regulatory proteins, lysR family signature.
216595002091	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595002092	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116
216595002093	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
216595002094	dimer interface [polypeptide binding]; other site
216595002095	active site
216595002098	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216595002099	3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831
216595002100	NAD(P) binding site [chemical binding]; other site
216595002101	active site
216595002103	Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289
216595002104	putative active site 1 [active]
216595002105	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185
216595002106	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
216595002107	dimer interface [polypeptide binding]; other site
216595002108	active site
216595002111	PS00606 Beta-ketoacyl synthases active site.
216595002112	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595002113	Methyltransferase domain; Region: Methyltransf_23; pfam13489
216595002114	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595002115	S-adenosylmethionine binding site [chemical binding]; other site
216595002116	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
216595002118	PS00017 ATP/GTP-binding site motif A (P-loop).
216595002119	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
216595002121	Predicted exporter [General function prediction only]; Region: COG4258
216595002122	PS00095 C-5 cytosine-specific DNA methylases C-terminal signature.
216595002123	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
216595002124	1 probable transmembrane helix predicted for PFLU0428 by TMHMM2.0 at aa 34-56
216595002125	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
216595002126	active site
216595002128	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
216595002129	active sites [active]
216595002130	tetramer interface [polypeptide binding]; other site
216595002132	PS00488 Phenylalanine and histidine ammonia-lyases signature.
216595002133	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
216595002134	acyl-activating enzyme (AAE) consensus motif; other site
216595002135	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
216595002136	active site
216595002137	AMP binding site [chemical binding]; other site
216595002138	CoA binding site [chemical binding]; other site
216595002139	FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493
216595002140	active site 2 [active]
216595002141	dimer interface [polypeptide binding]; other site
216595002145	Predicted membrane protein [Function unknown]; Region: COG4648
216595002146	acyl carrier protein; Provisional; Region: PRK05350
216595002148	Phosphopantetheine attachment site; Region: PP-binding; cl09936
216595002150	PS00012 Phosphopantetheine attachment site.
216595002151	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
216595002152	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
216595002153	putative acyl-acceptor binding pocket; other site
216595002155	1 probable transmembrane helix predicted for PFLU0437 by TMHMM2.0 at aa 20-42
216595002156	Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723
216595002157	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
216595002158	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
216595002159	P loop; other site
216595002160	Nucleotide binding site [chemical binding]; other site
216595002161	DTAP/Switch II; other site
216595002162	Switch I; other site
216595002164	thioredoxin 2; Provisional; Region: PRK10996
216595002165	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
216595002166	catalytic residues [active]
216595002168	PS00194 Thioredoxin family active site.
216595002169	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
216595002170	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216595002171	non-specific DNA binding site [nucleotide binding]; other site
216595002172	salt bridge; other site
216595002173	sequence-specific DNA binding site [nucleotide binding]; other site
216595002174	Uncharacterized conserved protein [Function unknown]; Region: COG0397
216595002175	hypothetical protein; Validated; Region: PRK00029
216595002177	hypothetical protein; Provisional; Region: PRK11281
216595002178	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
216595002179	Mechanosensitive ion channel; Region: MS_channel; pfam00924
216595002181	PS01246 Uncharacterized protein family UPF0003 signature.
216595002182	PS00012 Phosphopantetheine attachment site.
216595002183	PS00017 ATP/GTP-binding site motif A (P-loop).
216595002184	NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263
216595002185	TrkA-C domain; Region: TrkA_C; pfam02080
216595002186	Transporter associated domain; Region: CorC_HlyC; smart01091
216595002190	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
216595002191	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
216595002192	HAMP domain; Region: HAMP; pfam00672
216595002193	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595002194	dimer interface [polypeptide binding]; other site
216595002195	putative CheW interface [polypeptide binding]; other site
216595002198	Cell division protein ZapA; Region: ZapA; pfam05164
216595002200	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
216595002201	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
216595002202	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
216595002203	active site
216595002204	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
216595002205	PS00216 Sugar transport proteins signature 1.
216595002208	trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809
216595002209	Predicted transcriptional regulator [Transcription]; Region: COG3905
216595002210	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
216595002211	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
216595002212	Glutamate binding site [chemical binding]; other site
216595002213	NAD binding site [chemical binding]; other site
216595002214	catalytic residues [active]
216595002216	PS00070 Aldehyde dehydrogenases cysteine active site.
216595002218	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
216595002219	Na binding site [ion binding]; other site
216595002220	12 probable transmembrane helices predicted for PFLU0452 by TMHMM2.0 at aa 7-26, 66-88, 127-149, 164-183, 196-218, 233-255, 276-298, 326-348, 369-391, 401-422, 429-446 and 450-469
216595002222	PS00456 Sodium:solute symporter family signature 1.
216595002223	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
216595002224	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
216595002225	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
216595002227	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
216595002228	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
216595002229	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
216595002230	homodimer interface [polypeptide binding]; other site
216595002231	substrate-cofactor binding pocket; other site
216595002232	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595002233	catalytic residue [active]
216595002235	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
216595002237	PS00092 N-6 Adenine-specific DNA methylases signature.
216595002238	PS00092 N-6 Adenine-specific DNA methylases signature.
216595002240	methionine sulfoxide reductase A; Provisional; Region: PRK00058
216595002242	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
216595002243	putative active site [active]
216595002244	heme pocket [chemical binding]; other site
216595002245	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
216595002246	GAF domain; Region: GAF; pfam01590
216595002247	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595002248	PAS domain; Region: PAS_9; pfam13426
216595002249	putative active site [active]
216595002250	heme pocket [chemical binding]; other site
216595002251	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
216595002252	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216595002253	metal binding site [ion binding]; metal-binding site
216595002254	active site
216595002255	I-site; other site
216595002256	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
216595002261	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
216595002262	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
216595002263	E3 interaction surface; other site
216595002264	lipoyl attachment site [posttranslational modification]; other site
216595002265	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
216595002266	E3 interaction surface; other site
216595002267	lipoyl attachment site [posttranslational modification]; other site
216595002268	e3 binding domain; Region: E3_binding; pfam02817
216595002269	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
216595002273	PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site.
216595002275	PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site.
216595002276	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
216595002277	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
216595002278	dimer interface [polypeptide binding]; other site
216595002279	TPP-binding site [chemical binding]; other site
216595002282	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
216595002283	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
216595002284	metal binding triad; other site
216595002285	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
216595002286	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
216595002287	metal binding triad; other site
216595002288	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
216595002291	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
216595002292	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
216595002293	putative active site [active]
216595002295	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
216595002296	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
216595002297	putative active site [active]
216595002299	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
216595002300	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
216595002301	PS00225 Crystallins beta and gamma 'Greek key' motif signature.
216595002303	lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123
216595002305	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
216595002307	PS00108 Serine/Threonine protein kinases active-site signature.
216595002308	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; pfam06293
216595002310	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
216595002311	active site
216595002312	ATP binding site [chemical binding]; other site
216595002313	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
216595002315	Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305
216595002316	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
216595002317	putative ligand binding site [chemical binding]; other site
216595002318	PS00017 ATP/GTP-binding site motif A (P-loop).
216595002319	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
216595002320	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
216595002321	TM-ABC transporter signature motif; other site
216595002322	9 probable transmembrane helices predicted for PFLU0471 by TMHMM2.0 at aa 10-32, 39-61, 87-109, 116-135, 150-172, 200-222, 227-249, 256-278 and 282-301
216595002324	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595002325	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
216595002326	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216595002327	N-terminal plug; other site
216595002328	ligand-binding site [chemical binding]; other site
216595002330	PS00225 Crystallins beta and gamma 'Greek key' motif signature.
216595002332	Protein of unknown function (DUF1375); Region: DUF1375; pfam07119
216595002333	2 probable transmembrane helices predicted for PFLU0474 by TMHMM2.0 at aa 13-35 and 85-107
216595002334	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
216595002335	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
216595002337	Mig-14; Region: Mig-14; pfam07395
216595002338	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
216595002340	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
216595002341	1 probable transmembrane helix predicted for PFLU0477 by TMHMM2.0 at aa 26-48
216595002343	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
216595002344	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
216595002345	putative ADP-binding pocket [chemical binding]; other site
216595002347	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
216595002348	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
216595002349	active site
216595002351	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
216595002352	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
216595002353	Phosphotransferase enzyme family; Region: APH; pfam01636
216595002354	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
216595002356	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
216595002357	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
216595002358	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
216595002359	Walker A/P-loop; other site
216595002360	ATP binding site [chemical binding]; other site
216595002361	Q-loop/lid; other site
216595002362	ABC transporter signature motif; other site
216595002363	Walker B; other site
216595002364	D-loop; other site
216595002365	H-loop/switch region; other site
216595002366	5 probable transmembrane helices predicted for PFLU0481 by TMHMM2.0 at aa 39-61, 94-116, 172-189, 194-213 and 277-299
216595002369	PS00017 ATP/GTP-binding site motif A (P-loop).
216595002370	PS00211 ABC transporters family signature.
216595002371	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
216595002372	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
216595002373	putative ribose interaction site [chemical binding]; other site
216595002374	putative ADP binding site [chemical binding]; other site
216595002375	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
216595002376	active site
216595002377	nucleotide binding site [chemical binding]; other site
216595002378	HIGH motif; other site
216595002379	KMSKS motif; other site
216595002381	PS00583 pfkB family of carbohydrate kinases signature 1.
216595002383	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
216595002384	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216595002385	NAD(P) binding site [chemical binding]; other site
216595002386	active site
216595002388	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
216595002389	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
216595002390	active site
216595002391	catalytic tetrad [active]
216595002393	PS00017 ATP/GTP-binding site motif A (P-loop).
216595002394	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
216595002395	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
216595002397	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
216595002399	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595002400	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595002401	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
216595002402	dimerization interface [polypeptide binding]; other site
216595002405	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
216595002406	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
216595002407	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
216595002408	1 probable transmembrane helix predicted for PFLU0490 by TMHMM2.0 at aa 20-38
216595002411	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
216595002414	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
216595002415	ThiC-associated domain; Region: ThiC-associated; pfam13667
216595002416	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
216595002418	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595002419	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
216595002420	Na binding site [ion binding]; other site
216595002422	11 probable transmembrane helices predicted for PFLU0493 by TMHMM2.0 at aa 20-39, 60-82, 104-126, 133-150, 165-187, 199-221, 231-253, 280-299, 304-321, 334-356 and 362-384
216595002423	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
216595002424	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595002425	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
216595002426	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
216595002427	dimer interface [polypeptide binding]; other site
216595002428	ADP-ribose binding site [chemical binding]; other site
216595002429	active site
216595002430	nudix motif; other site
216595002431	metal binding site [ion binding]; metal-binding site
216595002433	Protein of unknown function (DUF1249); Region: DUF1249; pfam06853
216595002435	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
216595002436	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
216595002437	active site
216595002438	metal binding site [ion binding]; metal-binding site
216595002439	hexamer interface [polypeptide binding]; other site
216595002442	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
216595002443	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
216595002445	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
216595002446	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595002447	ATP binding site [chemical binding]; other site
216595002448	Mg2+ binding site [ion binding]; other site
216595002449	G-X-G motif; other site
216595002450	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
216595002451	anchoring element; other site
216595002452	dimer interface [polypeptide binding]; other site
216595002453	ATP binding site [chemical binding]; other site
216595002454	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
216595002455	active site
216595002456	metal binding site [ion binding]; metal-binding site
216595002457	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
216595002460	PS00177 DNA topoisomerase II signature.
216595002462	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
216595002463	SdiA-regulated; Region: SdiA-regulated; cd09971
216595002464	putative active site [active]
216595002465	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
216595002466	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
216595002467	CAP-like domain; other site
216595002468	active site
216595002469	primary dimer interface [polypeptide binding]; other site
216595002473	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
216595002474	Protein of unknown function (DUF330); Region: DUF330; pfam03886
216595002476	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595002477	Uncharacterized membrane protein affecting hemolysin expression [General function prediction only]; Region: AhpA; COG3726
216595002479	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
216595002480	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
216595002481	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
216595002482	phosphoserine phosphatase SerB; Region: serB; TIGR00338
216595002483	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216595002484	motif II; other site
216595002485	PS00228 Tubulin-beta mRNA autoregulation signal.
216595002488	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
216595002490	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
216595002491	active site residue [active]
216595002492	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
216595002493	active site residue [active]
216595002495	PS00683 Rhodanese C-terminal signature.
216595002497	PS00380 Rhodanese signature 1.
216595002498	HDOD domain; Region: HDOD; pfam08668
216595002499	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
216595002500	flagellar motor protein MotA; Validated; Region: PRK09110
216595002501	5 probable transmembrane helices predicted for PFLU0508 by TMHMM2.0 at aa 4-21, 26-48, 63-85, 172-191 and 201-223
216595002502	PS01307 Flagellar motor protein motA family signature.
216595002503	flagellar motor protein MotB; Validated; Region: motB; PRK09041
216595002504	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
216595002505	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
216595002506	ligand binding site [chemical binding]; other site
216595002507	1 probable transmembrane helix predicted for PFLU0509 by TMHMM2.0 at aa 21-43
216595002509	PemK-like protein; Region: PemK; cl00995
216595002510	GTPase RsgA; Reviewed; Region: PRK12288
216595002511	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
216595002512	RNA binding site [nucleotide binding]; other site
216595002513	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
216595002514	GTPase/Zn-binding domain interface [polypeptide binding]; other site
216595002515	GTP/Mg2+ binding site [chemical binding]; other site
216595002516	G4 box; other site
216595002517	G5 box; other site
216595002518	G1 box; other site
216595002519	Switch I region; other site
216595002520	G2 box; other site
216595002521	G3 box; other site
216595002522	Switch II region; other site
216595002524	PS00017 ATP/GTP-binding site motif A (P-loop).
216595002525	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
216595002526	catalytic site [active]
216595002527	putative active site [active]
216595002528	putative substrate binding site [chemical binding]; other site
216595002529	dimer interface [polypeptide binding]; other site
216595002531	Predicted membrane protein [Function unknown]; Region: COG2860
216595002532	UPF0126 domain; Region: UPF0126; pfam03458
216595002533	UPF0126 domain; Region: UPF0126; pfam03458
216595002535	7 probable transmembrane helices predicted for PFLU0513 by TMHMM2.0 at aa 4-21, 28-50, 63-80, 87-109, 113-135, 148-167 and 171-188
216595002537	epoxyqueuosine reductase; Region: TIGR00276
216595002538	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
216595002540	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
216595002542	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
216595002543	putative substrate binding site [chemical binding]; other site
216595002544	putative ATP binding site [chemical binding]; other site
216595002546	PS00017 ATP/GTP-binding site motif A (P-loop).
216595002547	PS01050 Uncharacterized protein family UPF0031 signature 2.
216595002548	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
216595002550	PS00017 ATP/GTP-binding site motif A (P-loop).
216595002551	AMIN domain; Region: AMIN; pfam11741
216595002552	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
216595002553	active site
216595002554	metal binding site [ion binding]; metal-binding site
216595002555	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
216595002556	1 probable transmembrane helix predicted for PFLU0517 by TMHMM2.0 at aa 7-29
216595002559	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
216595002560	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595002561	ATP binding site [chemical binding]; other site
216595002562	Mg2+ binding site [ion binding]; other site
216595002563	G-X-G motif; other site
216595002564	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
216595002565	ATP binding site [chemical binding]; other site
216595002566	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
216595002568	PS00058 DNA mismatch repair proteins mutL / hexB / PMS1 signature.
216595002571	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
216595002572	tRNA dimethylallyltransferase; Region: miaA; TIGR00174
216595002573	PS00017 ATP/GTP-binding site motif A (P-loop).
216595002575	bacterial Hfq-like; Region: Hfq; cd01716
216595002576	hexamer interface [polypeptide binding]; other site
216595002577	Sm1 motif; other site
216595002578	RNA binding site [nucleotide binding]; other site
216595002579	Sm2 motif; other site
216595002581	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
216595002582	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
216595002583	HflX GTPase family; Region: HflX; cd01878
216595002584	G1 box; other site
216595002585	GTP/Mg2+ binding site [chemical binding]; other site
216595002586	Switch I region; other site
216595002587	G2 box; other site
216595002588	G3 box; other site
216595002589	Switch II region; other site
216595002590	G4 box; other site
216595002591	G5 box; other site
216595002593	PS00017 ATP/GTP-binding site motif A (P-loop).
216595002594	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
216595002595	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
216595002596	HflK protein; Region: hflK; TIGR01933
216595002597	1 probable transmembrane helix predicted for PFLU0522 by TMHMM2.0 at aa 93-115
216595002599	HflC protein; Region: hflC; TIGR01932
216595002600	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
216595002601	1 probable transmembrane helix predicted for PFLU0523 by TMHMM2.0 at aa 7-29
216595002603	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421
216595002604	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
216595002605	dimer interface [polypeptide binding]; other site
216595002606	motif 1; other site
216595002607	active site
216595002608	motif 2; other site
216595002609	motif 3; other site
216595002611	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
216595002612	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
216595002613	GDP-binding site [chemical binding]; other site
216595002614	ACT binding site; other site
216595002615	IMP binding site; other site
216595002617	PS01266 Adenylosuccinate synthetase GTP-binding site.
216595002618	PS00513 Adenylosuccinate synthetase active site.
216595002619	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595002620	dimerization interface [polypeptide binding]; other site
216595002621	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
216595002622	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595002623	dimer interface [polypeptide binding]; other site
216595002624	putative CheW interface [polypeptide binding]; other site
216595002625	2 probable transmembrane helices predicted for PFLU0526 by TMHMM2.0 at aa 44-66 and 322-344
216595002628	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
216595002629	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595002630	dimer interface [polypeptide binding]; other site
216595002631	conserved gate region; other site
216595002632	putative PBP binding loops; other site
216595002633	ABC-ATPase subunit interface; other site
216595002634	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595002635	dimer interface [polypeptide binding]; other site
216595002636	conserved gate region; other site
216595002637	putative PBP binding loops; other site
216595002638	ABC-ATPase subunit interface; other site
216595002640	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595002642	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595002643	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
216595002644	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
216595002646	1 probable transmembrane helix predicted for PFLU0528 by TMHMM2.0 at aa 12-31
216595002647	ribonuclease R; Region: RNase_R; TIGR02063
216595002648	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
216595002649	RNB domain; Region: RNB; pfam00773
216595002650	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
216595002651	RNA binding site [nucleotide binding]; other site
216595002655	PS01175 Ribonuclease II family signature.
216595002657	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
216595002658	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
216595002659	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
216595002662	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
216595002664	PS01048 Ribosomal protein S6 signature.
216595002665	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
216595002667	PS00057 Ribosomal protein S18 signature.
216595002668	7 probable transmembrane helices predicted for PFLU0535 by TMHMM2.0 at aa 15-37, 49-66, 90-109, 151-173, 193-215, 220-242 and 252-274
216595002669	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
216595002670	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
216595002671	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
216595002673	PS00651 Ribosomal protein L9 signature.
216595002675	replicative DNA helicase; Provisional; Region: PRK05748
216595002676	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
216595002677	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
216595002678	Walker A motif; other site
216595002679	ATP binding site [chemical binding]; other site
216595002680	Walker B motif; other site
216595002681	DNA binding loops [nucleotide binding]
216595002684	PS00017 ATP/GTP-binding site motif A (P-loop).
216595002685	hypothetical protein; Provisional; Region: PRK01254
216595002686	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
216595002687	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
216595002690	PS01278 Uncharacterized protein family UPF0004 signature.
216595002691	4 probable transmembrane helices predicted for PFLU0540 by TMHMM2.0 at aa 13-35, 50-72, 79-98 and 103-122
216595002692	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
216595002693	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
216595002694	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
216595002695	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
216595002696	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
216595002699	Uncharacterized conserved protein [Function unknown]; Region: COG2308
216595002700	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
216595002701	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
216595002705	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
216595002706	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
216595002707	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
216595002710	azurin; Region: azurin; TIGR02695
216595002712	PS00196 Type-1 copper (blue) proteins signature.
216595002713	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
216595002714	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
216595002715	homodimer interface [polypeptide binding]; other site
216595002716	NAD binding pocket [chemical binding]; other site
216595002717	ATP binding pocket [chemical binding]; other site
216595002718	Mg binding site [ion binding]; other site
216595002719	active-site loop [active]
216595002721	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
216595002722	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
216595002723	active site
216595002725	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
216595002726	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595002727	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
216595002728	dimerization interface [polypeptide binding]; other site
216595002731	PS00044 Bacterial regulatory proteins, lysR family signature.
216595002732	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
216595002733	aldehyde dehydrogenase family 7 member; Region: PLN02315
216595002734	tetrameric interface [polypeptide binding]; other site
216595002735	NAD binding site [chemical binding]; other site
216595002736	catalytic residues [active]
216595002738	PS00687 Aldehyde dehydrogenases glutamic acid active site.
216595002739	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
216595002740	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
216595002742	Signal peptide predicted for PFLU0551 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.994 between residues 38 and 39
216595002743	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
216595002744	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
216595002745	dimerization interface [polypeptide binding]; other site
216595002746	ligand binding site [chemical binding]; other site
216595002747	1 probable transmembrane helix predicted for PFLU0551 by TMHMM2.0 at aa 21-38
216595002749	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
216595002750	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
216595002751	TM-ABC transporter signature motif; other site
216595002753	8 probable transmembrane helices predicted for PFLU0553 by TMHMM2.0 at aa 15-37, 44-61, 66-88, 149-171, 199-221, 228-250, 254-271 and 278-295
216595002754	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
216595002755	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
216595002756	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
216595002757	TM-ABC transporter signature motif; other site
216595002758	11 probable transmembrane helices predicted for PFLU0554 by TMHMM2.0 at aa 13-35, 45-65, 95-113, 117-139, 146-165, 170-192, 199-221, 265-282, 312-334, 354-376 and 389-406
216595002760	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
216595002761	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
216595002762	Walker A/P-loop; other site
216595002763	ATP binding site [chemical binding]; other site
216595002764	Q-loop/lid; other site
216595002765	ABC transporter signature motif; other site
216595002766	Walker B; other site
216595002767	D-loop; other site
216595002768	H-loop/switch region; other site
216595002770	PS00017 ATP/GTP-binding site motif A (P-loop).
216595002771	PS00211 ABC transporters family signature.
216595002772	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
216595002773	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
216595002774	Walker A/P-loop; other site
216595002775	ATP binding site [chemical binding]; other site
216595002776	Q-loop/lid; other site
216595002777	ABC transporter signature motif; other site
216595002778	Walker B; other site
216595002779	D-loop; other site
216595002780	H-loop/switch region; other site
216595002782	PS00017 ATP/GTP-binding site motif A (P-loop).
216595002783	PS00211 ABC transporters family signature.
216595002784	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
216595002785	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
216595002786	putative NAD(P) binding site [chemical binding]; other site
216595002787	homotetramer interface [polypeptide binding]; other site
216595002788	homodimer interface [polypeptide binding]; other site
216595002789	active site
216595002791	PS00061 Short-chain dehydrogenases/reductases family signature.
216595002792	Cation efflux family; Region: Cation_efflux; cl00316
216595002794	6 probable transmembrane helices predicted for PFLU0558 by TMHMM2.0 at aa 31-53, 57-76, 97-119, 129-148, 165-187 and 197-219
216595002795	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
216595002796	putative active cleft [active]
216595002798	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
216595002800	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
216595002802	PS00017 ATP/GTP-binding site motif A (P-loop).
216595002803	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
216595002804	UreF; Region: UreF; pfam01730
216595002805	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595002807	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
216595002808	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
216595002809	dimer interface [polypeptide binding]; other site
216595002810	catalytic residues [active]
216595002813	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
216595002814	NlpC/P60 family; Region: NLPC_P60; pfam00877
216595002816	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
216595002817	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216595002819	3 probable transmembrane helices predicted for PFLU0566 by TMHMM2.0 at aa 56-78, 85-107 and 127-149
216595002820	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
216595002821	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
216595002823	1 probable transmembrane helix predicted for PFLU0567 by TMHMM2.0 at aa 7-29
216595002824	Ferritin-like domain; Region: Ferritin; pfam00210
216595002825	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
216595002826	dinuclear metal binding motif [ion binding]; other site
216595002828	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
216595002830	PS00120 Lipases, serine active site.
216595002831	PS00215 Mitochondrial energy transfer proteins signature.
216595002832	EamA-like transporter family; Region: EamA; pfam00892
216595002835	Helix-turn-helix domain; Region: HTH_18; pfam12833
216595002836	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595002839	psiF repeat; Region: PsiF_repeat; pfam07769
216595002840	psiF repeat; Region: PsiF_repeat; pfam07769
216595002843	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
216595002844	7 probable transmembrane helices predicted for PFLU0573 by TMHMM2.0 at aa 10-41, 62-84, 149-168, 206-228, 233-250, 255-277 and 305-327
216595002845	putative chaperone; Provisional; Region: PRK11678
216595002846	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
216595002847	nucleotide binding site [chemical binding]; other site
216595002848	putative NEF/HSP70 interaction site [polypeptide binding]; other site
216595002849	SBD interface [polypeptide binding]; other site
216595002851	PS00329 Heat shock hsp70 proteins family signature 2.
216595002852	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
216595002853	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
216595002854	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
216595002855	substrate binding site [polypeptide binding]; other site
216595002856	dimer interface [polypeptide binding]; other site
216595002859	E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387
216595002862	urease subunit alpha; Reviewed; Region: ureC; PRK13207
216595002863	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
216595002864	subunit interactions [polypeptide binding]; other site
216595002865	active site
216595002866	flap region; other site
216595002868	PS00145 Urease active site.
216595002869	PS01120 Urease nickel ligands signature.
216595002871	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
216595002872	gamma-beta subunit interface [polypeptide binding]; other site
216595002873	alpha-beta subunit interface [polypeptide binding]; other site
216595002875	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216595002876	Coenzyme A binding pocket [chemical binding]; other site
216595002878	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
216595002879	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216595002880	Coenzyme A binding pocket [chemical binding]; other site
216595002882	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
216595002883	alpha-gamma subunit interface [polypeptide binding]; other site
216595002884	beta-gamma subunit interface [polypeptide binding]; other site
216595002886	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
216595002888	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
216595002889	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
216595002890	Walker A/P-loop; other site
216595002891	ATP binding site [chemical binding]; other site
216595002892	Q-loop/lid; other site
216595002893	ABC transporter signature motif; other site
216595002894	Walker B; other site
216595002895	D-loop; other site
216595002896	H-loop/switch region; other site
216595002898	PS00017 ATP/GTP-binding site motif A (P-loop).
216595002899	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
216595002900	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
216595002901	Walker A/P-loop; other site
216595002902	ATP binding site [chemical binding]; other site
216595002903	Q-loop/lid; other site
216595002904	ABC transporter signature motif; other site
216595002905	Walker B; other site
216595002906	D-loop; other site
216595002907	H-loop/switch region; other site
216595002909	PS00017 ATP/GTP-binding site motif A (P-loop).
216595002910	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
216595002911	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
216595002912	TM-ABC transporter signature motif; other site
216595002914	HEAT repeats; Region: HEAT_2; pfam13646
216595002915	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
216595002916	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
216595002917	TM-ABC transporter signature motif; other site
216595002919	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
216595002920	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
216595002921	putative ligand binding site [chemical binding]; other site
216595002922	Domain of unknown function (DUF4329); Region: DUF4329; pfam14220
216595002923	PS00014 Endoplasmic reticulum targeting sequence.
216595002924	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
216595002925	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
216595002926	ABC-ATPase subunit  interface; other site
216595002927	dimer interface [polypeptide binding]; other site
216595002928	putative PBP binding regions; other site
216595002930	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595002931	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
216595002932	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
216595002933	putative ligand binding residues [chemical binding]; other site
216595002935	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
216595002936	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
216595002937	Walker A/P-loop; other site
216595002938	ATP binding site [chemical binding]; other site
216595002939	Q-loop/lid; other site
216595002940	ABC transporter signature motif; other site
216595002941	Walker B; other site
216595002942	D-loop; other site
216595002943	H-loop/switch region; other site
216595002945	PS00211 ABC transporters family signature.
216595002946	PS00017 ATP/GTP-binding site motif A (P-loop).
216595002947	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
216595002948	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216595002949	N-terminal plug; other site
216595002950	ligand-binding site [chemical binding]; other site
216595002952	PS00815 Alpha-isopropylmalate and homocitrate synthases signature 1.
216595002954	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
216595002955	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
216595002956	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
216595002957	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
216595002958	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
216595002964	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216595002965	N-terminal plug; other site
216595002966	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
216595002967	ligand-binding site [chemical binding]; other site
216595002970	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
216595002971	1 probable transmembrane helix predicted for PFLU0596 by TMHMM2.0 at aa 17-39
216595002972	Protein of unknown function (DUF461); Region: DUF461; pfam04314
216595002974	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
216595002975	1 probable transmembrane helix predicted for PFLU0598 by TMHMM2.0 at aa 7-29
216595002976	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
216595002977	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
216595002979	PS00304 Small, acid-soluble spore proteins, alpha/beta type, signature 1.
216595002980	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
216595002981	active site
216595002982	putative homodimer interface [polypeptide binding]; other site
216595002983	SAM binding site [chemical binding]; other site
216595002984	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
216595002985	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595002986	S-adenosylmethionine binding site [chemical binding]; other site
216595002988	precorrin-3B synthase; Region: CobG; TIGR02435
216595002989	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
216595002992	PS00178 Aminoacyl-transfer RNA synthetases class-I signature.
216595002994	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
216595002995	Precorrin-8X methylmutase; Region: CbiC; pfam02570
216595002997	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
216595002998	active site
216595002999	SAM binding site [chemical binding]; other site
216595003000	homodimer interface [polypeptide binding]; other site
216595003002	PS00840 Uroporphyrin-III C-methyltransferase signature 2.
216595003003	PS00215 Mitochondrial energy transfer proteins signature.
216595003004	Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073
216595003005	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
216595003006	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
216595003007	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
216595003008	active site
216595003009	SAM binding site [chemical binding]; other site
216595003010	homodimer interface [polypeptide binding]; other site
216595003012	PS00300 SRP54-type proteins GTP-binding domain signature.
216595003014	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
216595003015	tetramer interface [polypeptide binding]; other site
216595003016	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
216595003018	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
216595003019	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
216595003020	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
216595003021	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595003022	dimer interface [polypeptide binding]; other site
216595003023	phosphorylation site [posttranslational modification]
216595003024	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595003025	ATP binding site [chemical binding]; other site
216595003026	Mg2+ binding site [ion binding]; other site
216595003027	G-X-G motif; other site
216595003028	Response regulator receiver domain; Region: Response_reg; pfam00072
216595003029	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595003030	active site
216595003031	phosphorylation site [posttranslational modification]
216595003032	intermolecular recognition site; other site
216595003033	dimerization interface [polypeptide binding]; other site
216595003034	Response regulator receiver domain; Region: Response_reg; pfam00072
216595003035	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595003036	active site
216595003037	phosphorylation site [posttranslational modification]
216595003038	intermolecular recognition site; other site
216595003039	dimerization interface [polypeptide binding]; other site
216595003046	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
216595003047	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
216595003048	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
216595003049	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
216595003051	PS00184 Phosphoribosylglycinamide synthetase signature.
216595003054	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
216595003055	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
216595003056	purine monophosphate binding site [chemical binding]; other site
216595003057	dimer interface [polypeptide binding]; other site
216595003058	putative catalytic residues [active]
216595003059	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
216595003060	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
216595003063	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
216595003064	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
216595003066	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
216595003067	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
216595003068	FMN binding site [chemical binding]; other site
216595003069	active site
216595003070	catalytic residues [active]
216595003071	substrate binding site [chemical binding]; other site
216595003073	PS01136 Uncharacterized protein family UPF0034 signature.
216595003074	MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098
216595003075	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
216595003076	1 probable transmembrane helix predicted for PFLU0615 by TMHMM2.0 at aa 263-285
216595003077	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
216595003078	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595003079	S-adenosylmethionine binding site [chemical binding]; other site
216595003081	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
216595003082	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
216595003083	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
216595003084	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
216595003087	PS00867 Carbamoyl-phosphate synthase subdomain signature 2.
216595003088	PS00866 Carbamoyl-phosphate synthase subdomain signature 1.
216595003090	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
216595003091	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
216595003092	carboxyltransferase (CT) interaction site; other site
216595003093	biotinylation site [posttranslational modification]; other site
216595003095	PS00188 Biotin-requiring enzymes attachment site.
216595003096	PS00017 ATP/GTP-binding site motif A (P-loop).
216595003097	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
216595003098	Dehydroquinase class II; Region: DHquinase_II; pfam01220
216595003099	active site
216595003100	trimer interface [polypeptide binding]; other site
216595003101	dimer interface [polypeptide binding]; other site
216595003103	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
216595003104	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595003105	dimer interface [polypeptide binding]; other site
216595003106	putative CheW interface [polypeptide binding]; other site
216595003108	1 probable transmembrane helix predicted for PFLU0620 by TMHMM2.0 at aa 5-27
216595003109	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
216595003110	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595003111	active site
216595003112	phosphorylation site [posttranslational modification]
216595003113	intermolecular recognition site; other site
216595003114	dimerization interface [polypeptide binding]; other site
216595003115	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216595003116	metal binding site [ion binding]; metal-binding site
216595003117	active site
216595003118	I-site; other site
216595003121	Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; pfam10095
216595003122	1 probable transmembrane helix predicted for PFLU0623 by TMHMM2.0 at aa 29-51
216595003123	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
216595003124	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
216595003125	nudix motif; other site
216595003127	PS00893 mutT domain signature.
216595003128	translation initiation factor Sui1; Validated; Region: PRK06824
216595003129	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
216595003130	putative rRNA binding site [nucleotide binding]; other site
216595003132	PS01118 Translation initiation factor SUI1 signature.
216595003133	arginine decarboxylase; Provisional; Region: PRK05354
216595003134	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
216595003135	dimer interface [polypeptide binding]; other site
216595003136	active site
216595003137	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
216595003138	catalytic residues [active]
216595003139	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
216595003141	PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2.
216595003143	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
216595003144	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
216595003145	substrate binding pocket [chemical binding]; other site
216595003147	PS00120 Lipases, serine active site.
216595003148	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
216595003149	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
216595003152	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
216595003153	MG2 domain; Region: A2M_N; pfam01835
216595003154	Alpha-2-macroglobulin family; Region: A2M; pfam00207
216595003155	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
216595003156	surface patch; other site
216595003157	thioester region; other site
216595003158	specificity defining residues; other site
216595003159	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595003162	penicillin-binding protein 1C; Provisional; Region: PRK11240
216595003163	Transglycosylase; Region: Transgly; pfam00912
216595003164	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
216595003165	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
216595003166	1 probable transmembrane helix predicted for PFLU0631 by TMHMM2.0 at aa 5-24
216595003170	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
216595003171	homodimer interface [polypeptide binding]; other site
216595003172	chemical substrate binding site [chemical binding]; other site
216595003173	oligomer interface [polypeptide binding]; other site
216595003174	metal binding site [ion binding]; metal-binding site
216595003175	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595003176	S-adenosylmethionine binding site [chemical binding]; other site
216595003178	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
216595003179	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595003180	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
216595003181	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595003182	Predicted membrane protein [Function unknown]; Region: COG4655
216595003183	Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977
216595003184	1 probable transmembrane helix predicted for PFLU0636 by TMHMM2.0 at aa 13-32
216595003185	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595003186	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
216595003187	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595003188	putative active site [active]
216595003189	heme pocket [chemical binding]; other site
216595003190	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595003191	dimer interface [polypeptide binding]; other site
216595003192	phosphorylation site [posttranslational modification]
216595003193	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595003194	ATP binding site [chemical binding]; other site
216595003195	Mg2+ binding site [ion binding]; other site
216595003196	G-X-G motif; other site
216595003201	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
216595003202	TadE-like protein; Region: TadE; pfam07811
216595003204	1 probable transmembrane helix predicted for PFLU0638 by TMHMM2.0 at aa 13-35
216595003206	4 probable transmembrane helices predicted for PFLU0639 by TMHMM2.0 at aa 24-46, 56-78, 85-107 and 131-148
216595003207	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
216595003208	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595003209	active site
216595003210	phosphorylation site [posttranslational modification]
216595003211	intermolecular recognition site; other site
216595003212	dimerization interface [polypeptide binding]; other site
216595003213	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216595003214	DNA binding residues [nucleotide binding]
216595003215	dimerization interface [polypeptide binding]; other site
216595003218	Protein of unknown function (DUF3613); Region: DUF3613; pfam12266
216595003219	TPR repeat; Region: TPR_11; pfam13414
216595003220	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
216595003221	binding surface
216595003222	TPR motif; other site
216595003224	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595003226	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
216595003227	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
216595003229	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
216595003230	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
216595003231	ATP binding site [chemical binding]; other site
216595003232	Walker A motif; other site
216595003233	hexamer interface [polypeptide binding]; other site
216595003234	Walker B motif; other site
216595003236	PS00017 ATP/GTP-binding site motif A (P-loop).
216595003237	Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963
216595003238	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
216595003239	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
216595003240	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
216595003241	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
216595003243	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595003244	1 probable transmembrane helix predicted for PFLU0647 by TMHMM2.0 at aa 7-29
216595003245	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
216595003246	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
216595003248	1 probable transmembrane helix predicted for PFLU0648 by TMHMM2.0 at aa 5-27
216595003249	Flp/Fap pilin component; Region: Flp_Fap; cl01585
216595003251	1 probable transmembrane helix predicted for PFLU0649 by TMHMM2.0 at aa 25-47
216595003252	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595003253	active site
216595003254	phosphorylation site [posttranslational modification]
216595003255	intermolecular recognition site; other site
216595003256	dimerization interface [polypeptide binding]; other site
216595003258	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
216595003259	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
216595003260	PS00213 Lipocalin signature.
216595003262	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595003263	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
216595003264	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
216595003265	active site 2 [active]
216595003266	active site 1 [active]
216595003268	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
216595003269	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216595003270	NAD(P) binding site [chemical binding]; other site
216595003271	active site
216595003273	PS00061 Short-chain dehydrogenases/reductases family signature.
216595003274	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
216595003275	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
216595003276	dimer interface [polypeptide binding]; other site
216595003277	active site
216595003280	Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718
216595003281	RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145
216595003282	ATP binding site [chemical binding]; other site
216595003284	PS00109 Tyrosine protein kinases specific active-site signature.
216595003285	PS01245 RIO1/ZK632.3/MJ0444 family signature.
216595003286	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
216595003287	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
216595003288	DNA binding residues [nucleotide binding]
216595003289	dimer interface [polypeptide binding]; other site
216595003290	copper binding site [ion binding]; other site
216595003293	PS00552 Bacterial regulatory proteins, merR family signature.
216595003294	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
216595003295	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
216595003296	metal-binding site [ion binding]
216595003297	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
216595003299	PS01229 Hypothetical cof family signature 2.
216595003300	PS00154 E1-E2 ATPases phosphorylation site.
216595003303	PS01047 Heavy-metal-associated domain.
216595003304	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
216595003305	metal-binding site [ion binding]
216595003307	PS01047 Heavy-metal-associated domain.
216595003308	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595003309	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
216595003310	putative substrate translocation pore; other site
216595003311	12 probable transmembrane helices predicted for PFLU0661 by TMHMM2.0 at aa 5-26, 41-63, 70-92, 96-118, 130-152, 157-179, 207-229, 244-266, 273-295, 300-322, 335-357 and 362-384
216595003313	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
216595003314	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
216595003315	putative NAD(P) binding site [chemical binding]; other site
216595003316	dimer interface [polypeptide binding]; other site
216595003319	Uncharacterized conserved protein [Function unknown]; Region: COG1359
216595003321	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595003322	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595003323	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
216595003324	putative effector binding pocket; other site
216595003325	dimerization interface [polypeptide binding]; other site
216595003327	PS00044 Bacterial regulatory proteins, lysR family signature.
216595003329	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
216595003330	dimerization interface [polypeptide binding]; other site
216595003331	putative DNA binding site [nucleotide binding]; other site
216595003332	putative Zn2+ binding site [ion binding]; other site
216595003333	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
216595003334	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
216595003335	active site
216595003336	purine riboside binding site [chemical binding]; other site
216595003338	Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
216595003339	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
216595003340	11 probable transmembrane helices predicted for PFLU0668 by TMHMM2.0 at aa 12-29, 34-56, 69-91, 102-124, 137-154, 164-181, 211-233, 253-275, 282-301, 316-335 and 342-361
216595003342	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
216595003343	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
216595003344	active site
216595003345	putative substrate binding pocket [chemical binding]; other site
216595003347	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
216595003348	short chain dehydrogenase; Provisional; Region: PRK08177
216595003349	NAD(P) binding site [chemical binding]; other site
216595003350	active site
216595003352	Uncharacterized conserved protein [Function unknown]; Region: COG1739
216595003353	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
216595003354	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
216595003357	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
216595003358	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216595003359	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
216595003362	xanthine permease; Region: pbuX; TIGR03173
216595003363	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
216595003365	PS01116 Xanthine/uracil permeases family signature.
216595003366	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595003367	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595003368	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
216595003369	dimerization interface [polypeptide binding]; other site
216595003372	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
216595003373	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
216595003374	inhibitor-cofactor binding pocket; inhibition site
216595003375	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595003376	catalytic residue [active]
216595003378	PS00639 Eukaryotic thiol (cysteine) proteases histidine active site.
216595003379	PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site.
216595003380	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
216595003381	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
216595003382	tetrameric interface [polypeptide binding]; other site
216595003383	NAD binding site [chemical binding]; other site
216595003384	catalytic residues [active]
216595003386	PS00070 Aldehyde dehydrogenases cysteine active site.
216595003387	Paraquat-inducible protein A; Region: PqiA; pfam04403
216595003389	4 probable transmembrane helices predicted for PFLU0677 by TMHMM2.0 at aa 59-81, 109-131, 155-173 and 178-200
216595003390	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
216595003391	Paraquat-inducible protein A; Region: PqiA; pfam04403
216595003393	PS00190 Cytochrome c family heme-binding site signature.
216595003394	4 probable transmembrane helices predicted for PFLU0678 by TMHMM2.0 at aa 47-69, 98-120, 141-163 and 173-191
216595003395	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
216595003396	mce related protein; Region: MCE; pfam02470
216595003397	mce related protein; Region: MCE; pfam02470
216595003398	mce related protein; Region: MCE; pfam02470
216595003399	mce related protein; Region: MCE; pfam02470
216595003400	mce related protein; Region: MCE; pfam02470
216595003401	mce related protein; Region: MCE; pfam02470
216595003402	1 probable transmembrane helix predicted for PFLU0679 by TMHMM2.0 at aa 12-34
216595003409	PS00017 ATP/GTP-binding site motif A (P-loop).
216595003410	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
216595003411	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
216595003412	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216595003413	Coenzyme A binding pocket [chemical binding]; other site
216595003416	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
216595003417	active site clefts [active]
216595003418	zinc binding site [ion binding]; other site
216595003419	dimer interface [polypeptide binding]; other site
216595003421	PS00705 Prokaryotic-type carbonic anhydrases signature 2.
216595003422	SET domain; Region: SET; cl02566
216595003423	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
216595003424	acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397
216595003426	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595003427	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
216595003429	metabolite-proton symporter; Region: 2A0106; TIGR00883
216595003430	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595003431	12 probable transmembrane helices predicted for PFLU0692 by TMHMM2.0 at aa 20-42, 57-79, 92-114, 124-146, 159-181, 196-215, 246-268, 283-305, 317-339, 344-366, 373-395 and 400-422
216595003433	PS00216 Sugar transport proteins signature 1.
216595003434	PS00217 Sugar transport proteins signature 2.
216595003435	Helix-turn-helix; Region: HTH_3; pfam01381
216595003436	salt bridge; other site
216595003437	non-specific DNA binding site [nucleotide binding]; other site
216595003438	sequence-specific DNA binding site [nucleotide binding]; other site
216595003439	Domain of unknown function (DUF955); Region: DUF955; cl01076
216595003442	PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.
216595003443	Domain of unknown function (DUF4411); Region: DUF4411; pfam14367
216595003444	GntP family permease; Region: GntP_permease; pfam02447
216595003445	fructuronate transporter; Provisional; Region: PRK10034; cl15264
216595003447	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
216595003448	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
216595003449	5 probable transmembrane helices predicted for PFLU0696 by TMHMM2.0 at aa 17-39, 43-65, 85-104, 119-141 and 162-181
216595003451	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
216595003452	1 probable transmembrane helix predicted for PFLU0697 by TMHMM2.0 at aa 7-29
216595003454	PS00017 ATP/GTP-binding site motif A (P-loop).
216595003456	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
216595003457	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
216595003458	HlyD family secretion protein; Region: HlyD_3; pfam13437
216595003460	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
216595003462	12 probable transmembrane helices predicted for PFLU0699 by TMHMM2.0 at aa 13-32, 348-365, 367-386, 396-418, 452-474, 484-506, 539-556, 883-900, 907-926, 936-958, 979-1001 and 1011-1033
216595003463	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
216595003464	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595003465	dimerization interface [polypeptide binding]; other site
216595003466	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595003467	dimer interface [polypeptide binding]; other site
216595003468	phosphorylation site [posttranslational modification]
216595003469	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595003470	ATP binding site [chemical binding]; other site
216595003471	Mg2+ binding site [ion binding]; other site
216595003472	G-X-G motif; other site
216595003476	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
216595003477	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595003478	active site
216595003479	phosphorylation site [posttranslational modification]
216595003480	intermolecular recognition site; other site
216595003481	dimerization interface [polypeptide binding]; other site
216595003482	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216595003483	DNA binding site [nucleotide binding]
216595003486	outer membrane porin, OprD family; Region: OprD; pfam03573
216595003488	Protein of unknown function (DUF2790); Region: DUF2790; pfam10976
216595003489	1 probable transmembrane helix predicted for PFLU0703 by TMHMM2.0 at aa 3-25
216595003490	PAS domain; Region: PAS_9; pfam13426
216595003491	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595003492	putative active site [active]
216595003493	heme pocket [chemical binding]; other site
216595003494	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595003495	PAS domain; Region: PAS_9; pfam13426
216595003496	putative active site [active]
216595003497	heme pocket [chemical binding]; other site
216595003498	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595003499	dimer interface [polypeptide binding]; other site
216595003500	putative CheW interface [polypeptide binding]; other site
216595003504	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
216595003505	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
216595003506	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595003510	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
216595003511	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
216595003512	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
216595003513	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
216595003515	PS00843 D-alanine--D-alanine ligase signature 1.
216595003517	PS00844 D-alanine--D-alanine ligase signature 2.
216595003519	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
216595003520	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
216595003522	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595003523	Type III secretion system gene cluster
216595003524	Pathogenicity factor; Region: AvrE; pfam11725
216595003525	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
216595003526	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
216595003527	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
216595003528	DNA binding residues [nucleotide binding]
216595003531	ggaaccnnnnnnnnnnnnnnnnccacnna
216595003533	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
216595003534	type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551
216595003535	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
216595003536	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
216595003538	type III secretion system protein YscR; Provisional; Region: PRK12797
216595003539	4 probable transmembrane helices predicted for PFLU0715 by TMHMM2.0 at aa 10-32, 53-75, 158-180 and 187-209
216595003541	PS00043 Bacterial regulatory proteins, gntR family signature.
216595003542	PS01060 Flagella transport protein fliP family signature 1.
216595003543	PS01061 Flagella transport protein fliP family signature 2.
216595003544	type III secretion protein, HrpO family; Region: fliQ_rel_III; TIGR01403
216595003546	2 probable transmembrane helices predicted for PFLU0716 by TMHMM2.0 at aa 13-35 and 45-67
216595003547	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
216595003549	6 probable transmembrane helices predicted for PFLU0717 by TMHMM2.0 at aa 10-29, 41-60, 75-97, 129-148, 183-205 and 218-240
216595003550	type III secretion protein, YscU/HrpY family; Region: FlhB_rel_III; TIGR01404
216595003551	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
216595003553	3 probable transmembrane helices predicted for PFLU0718 by TMHMM2.0 at aa 77-99, 143-165 and 186-208
216595003554	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595003555	type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516
216595003556	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
216595003557	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
216595003561	HrpE/YscL/FliH and V-type ATPase subunit E; Region: HrpE; pfam06188
216595003563	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
216595003564	1 probable transmembrane helix predicted for PFLU0726 by TMHMM2.0 at aa 228-250
216595003566	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
216595003567	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595003568	Walker A motif; other site
216595003569	ATP binding site [chemical binding]; other site
216595003570	Walker B motif; other site
216595003571	arginine finger; other site
216595003572	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
216595003575	PS00675 Sigma-54 interaction domain ATP-binding region A signature.
216595003576	GTP-binding protein YchF; Reviewed; Region: PRK09601
216595003577	YchF GTPase; Region: YchF; cd01900
216595003578	G1 box; other site
216595003579	GTP/Mg2+ binding site [chemical binding]; other site
216595003580	Switch I region; other site
216595003581	G2 box; other site
216595003582	Switch II region; other site
216595003583	G3 box; other site
216595003584	G4 box; other site
216595003585	G5 box; other site
216595003586	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
216595003589	PS00017 ATP/GTP-binding site motif A (P-loop).
216595003590	PS00443 Glutamine amidotransferases class-II active site.
216595003591	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
216595003592	putative active site [active]
216595003593	catalytic residue [active]
216595003595	PS01196 Peptidyl-tRNA hydrolase signature 2.
216595003596	PS01195 Peptidyl-tRNA hydrolase signature 1.
216595003597	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
216595003598	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
216595003599	5S rRNA interface [nucleotide binding]; other site
216595003600	CTC domain interface [polypeptide binding]; other site
216595003601	L16 interface [polypeptide binding]; other site
216595003603	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
216595003604	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
216595003605	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
216595003606	active site
216595003607	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595003609	PS00103 Purine/pyrimidine phosphoribosyl transferases signature.
216595003610	PS00114 Phosphoribosyl pyrophosphate synthetase signature.
216595003611	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
216595003612	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
216595003613	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
216595003616	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
216595003617	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
216595003619	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595003620	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
216595003621	TPR motif; other site
216595003622	binding surface
216595003623	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
216595003624	binding surface
216595003625	TPR motif; other site
216595003626	TPR repeat; Region: TPR_11; pfam13414
216595003627	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
216595003628	binding surface
216595003629	TPR motif; other site
216595003632	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
216595003633	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
216595003634	tRNA; other site
216595003635	putative tRNA binding site [nucleotide binding]; other site
216595003636	putative NADP binding site [chemical binding]; other site
216595003637	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
216595003639	PS00747 Glutamyl-tRNA reductase signature.
216595003642	peptide chain release factor 1; Validated; Region: prfA; PRK00591
216595003643	This domain is found in peptide chain release factors; Region: PCRF; smart00937
216595003644	RF-1 domain; Region: RF-1; pfam00472
216595003647	PS00745 Prokaryotic-type class I peptide chain release factors signature.
216595003648	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
216595003649	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595003650	S-adenosylmethionine binding site [chemical binding]; other site
216595003652	PS00092 N-6 Adenine-specific DNA methylases signature.
216595003653	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
216595003654	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
216595003655	ATP binding site [chemical binding]; other site
216595003656	substrate interface [chemical binding]; other site
216595003658	1 probable transmembrane helix predicted for PFLU0740 by TMHMM2.0 at aa 32-54
216595003660	glutamate racemase; Provisional; Region: PRK00865
216595003662	PS00923 Aspartate and glutamate racemases signature 1.
216595003663	PS00924 Aspartate and glutamate racemases signature 2.
216595003664	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
216595003665	Flagellin N-methylase; Region: FliB; pfam03692
216595003667	Protein of unknown function (DUF2878); Region: DUF2878; pfam11086
216595003668	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
216595003669	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595003670	S-adenosylmethionine binding site [chemical binding]; other site
216595003672	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
216595003674	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
216595003675	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
216595003677	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216595003678	short chain dehydrogenase; Provisional; Region: PRK06101
216595003679	NAD(P) binding site [chemical binding]; other site
216595003680	active site
216595003682	PS00061 Short-chain dehydrogenases/reductases family signature.
216595003683	SnoaL-like domain; Region: SnoaL_2; pfam12680
216595003685	deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674
216595003686	DNA photolyase; Region: DNA_photolyase; pfam00875
216595003688	PS00394 DNA photolyases class 1 signature 1.
216595003690	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
216595003691	DNA binding residues [nucleotide binding]
216595003692	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
216595003693	B12 binding domain; Region: B12-binding_2; pfam02607
216595003695	Protein of unknown function (DUF523); Region: DUF523; pfam04463
216595003696	Uncharacterized conserved protein [Function unknown]; Region: COG3272
216595003697	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
216595003700	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
216595003701	Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493
216595003702	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
216595003703	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
216595003706	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216595003707	TIGR01777 family protein; Region: yfcH
216595003708	NAD(P) binding site [chemical binding]; other site
216595003709	active site
216595003712	ferrochelatase; Reviewed; Region: hemH; PRK00035
216595003713	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
216595003714	C-terminal domain interface [polypeptide binding]; other site
216595003715	active site
216595003716	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
216595003717	active site
216595003718	N-terminal domain interface [polypeptide binding]; other site
216595003720	PS00398 Site-specific recombinases signature 2.
216595003721	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
216595003722	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216595003723	N-terminal plug; other site
216595003724	ligand-binding site [chemical binding]; other site
216595003726	PS00017 ATP/GTP-binding site motif A (P-loop).
216595003728	serine endoprotease; Provisional; Region: PRK10898
216595003729	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
216595003730	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
216595003731	protein binding site [polypeptide binding]; other site
216595003734	1 probable transmembrane helix predicted for PFLU0758 by TMHMM2.0 at aa 7-24
216595003735	Uncharacterized conserved protein [Function unknown]; Region: COG0327
216595003736	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
216595003738	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
216595003739	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
216595003740	Active Sites [active]
216595003742	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
216595003743	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
216595003744	CysD dimerization site [polypeptide binding]; other site
216595003745	G1 box; other site
216595003746	putative GEF interaction site [polypeptide binding]; other site
216595003747	GTP/Mg2+ binding site [chemical binding]; other site
216595003748	Switch I region; other site
216595003749	G2 box; other site
216595003750	G3 box; other site
216595003751	Switch II region; other site
216595003752	G4 box; other site
216595003753	G5 box; other site
216595003754	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
216595003755	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
216595003756	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
216595003757	ligand-binding site [chemical binding]; other site
216595003759	PS00017 ATP/GTP-binding site motif A (P-loop).
216595003760	PS00301 GTP-binding elongation factors signature.
216595003763	PS00017 ATP/GTP-binding site motif A (P-loop).
216595003764	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
216595003765	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
216595003766	putative acyl-acceptor binding pocket; other site
216595003768	phosphate acetyltransferase; Reviewed; Region: PRK05632
216595003769	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
216595003770	DRTGG domain; Region: DRTGG; pfam07085
216595003771	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
216595003774	Protein of unknown function (DUF3565); Region: DUF3565; pfam12088
216595003775	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
216595003776	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
216595003778	PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2.
216595003779	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
216595003781	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
216595003782	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
216595003783	13 probable transmembrane helices predicted for PFLU0766 by TMHMM2.0 at aa 26-45, 88-110, 130-152, 159-181, 186-203, 237-259, 274-296, 309-328, 348-370, 383-405, 410-429, 441-463 and 478-500
216595003785	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
216595003786	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
216595003787	active site
216595003788	Riboflavin kinase; Region: Flavokinase; pfam01687
216595003791	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
216595003792	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
216595003793	active site
216595003794	HIGH motif; other site
216595003795	nucleotide binding site [chemical binding]; other site
216595003796	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
216595003797	active site
216595003798	KMSKS motif; other site
216595003799	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
216595003800	tRNA binding surface [nucleotide binding]; other site
216595003801	anticodon binding site; other site
216595003802	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
216595003804	PS00178 Aminoacyl-transfer RNA synthetases class-I signature.
216595003805	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595003808	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
216595003809	5 probable transmembrane helices predicted for PFLU0769 by TMHMM2.0 at aa 24-43, 58-80, 87-104, 114-131 and 152-174
216595003811	PS00855 Signal peptidases II signature.
216595003812	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
216595003813	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
216595003815	PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1.
216595003816	PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2.
216595003817	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
216595003818	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
216595003820	pilus (type IV secretion system) biosynthesis gene cluster. Possibly related to competence
216595003821	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
216595003822	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
216595003823	Type II transport protein GspH; Region: GspH; pfam12019
216595003824	1 probable transmembrane helix predicted for PFLU0772 by TMHMM2.0 at aa 7-29
216595003826	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
216595003827	PS00409 Prokaryotic N-terminal methylation site.
216595003828	1 probable transmembrane helix predicted for PFLU0773 by TMHMM2.0 at aa 29-51
216595003829	PS00409 Prokaryotic N-terminal methylation site.
216595003830	1 probable transmembrane helix predicted for PFLU0774 by TMHMM2.0 at aa 7-29
216595003831	Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726
216595003832	1 probable transmembrane helix predicted for PFLU0775 by TMHMM2.0 at aa 12-34
216595003833	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
216595003835	PS00409 Prokaryotic N-terminal methylation site.
216595003836	1 probable transmembrane helix predicted for PFLU0776 by TMHMM2.0 at aa 10-32
216595003837	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
216595003838	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
216595003840	1 probable transmembrane helix predicted for PFLU0777 by TMHMM2.0 at aa 33-55
216595003841	1 probable transmembrane helix predicted for PFLU0778 by TMHMM2.0 at aa 4-21
216595003842	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
216595003843	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595003844	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
216595003845	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
216595003846	RNA binding surface [nucleotide binding]; other site
216595003847	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
216595003848	active site
216595003851	PS01129 Rlu family of pseudouridine synthase signature.
216595003852	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
216595003853	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
216595003855	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
216595003856	Clp amino terminal domain; Region: Clp_N; pfam02861
216595003857	Clp amino terminal domain; Region: Clp_N; pfam02861
216595003858	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595003859	Walker A motif; other site
216595003860	ATP binding site [chemical binding]; other site
216595003861	Walker B motif; other site
216595003862	arginine finger; other site
216595003863	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595003864	Walker A motif; other site
216595003865	ATP binding site [chemical binding]; other site
216595003866	Walker B motif; other site
216595003867	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
216595003871	PS00017 ATP/GTP-binding site motif A (P-loop).
216595003872	PS00870 Chaperonins clpA/B signature 1.
216595003874	PS00017 ATP/GTP-binding site motif A (P-loop).
216595003875	PS00871 Chaperonins clpA/B signature 2.
216595003876	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
216595003877	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
216595003880	Protein of unknown function (DUF3094); Region: DUF3094; pfam11293
216595003881	1 probable transmembrane helix predicted for PFLU0784 by TMHMM2.0 at aa 41-63
216595003882	Protein of unknown function (DUF1780); Region: DUF1780; pfam08682
216595003884	Predicted membrane protein [Function unknown]; Region: COG3235
216595003885	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
216595003886	6 probable transmembrane helices predicted for PFLU0786 by TMHMM2.0 at aa 7-29, 44-58, 70-92, 107-129, 141-163 and 183-205
216595003887	DNA gyrase inhibitor; Reviewed; Region: PRK00418
216595003889	PS00237 G-protein coupled receptors signature.
216595003890	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
216595003891	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
216595003892	CoA-binding site [chemical binding]; other site
216595003893	ATP-binding [chemical binding]; other site
216595003895	PS01294 Uncharacterized protein family UPF0038 signature.
216595003896	PS00017 ATP/GTP-binding site motif A (P-loop).
216595003897	pilus (type IV secretion system) biosynthesis gene cluster
216595003898	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
216595003899	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
216595003900	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
216595003903	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
216595003904	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
216595003905	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
216595003908	PS00874 Bacterial type II secretion system protein F signature.
216595003909	Pilin (bacterial filament); Region: Pilin; pfam00114
216595003911	PS00409 Prokaryotic N-terminal methylation site.
216595003912	1 probable transmembrane helix predicted for PFLU0793 by TMHMM2.0 at aa 10-32
216595003914	O-Antigen ligase; Region: Wzy_C; pfam04932
216595003915	11 probable transmembrane helices predicted for PFLU0794 by TMHMM2.0 at aa 9-31, 36-55, 62-81, 85-107, 120-142, 162-184, 191-213, 233-255, 358-375, 385-402 and 411-433
216595003917	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05742
216595003918	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
216595003919	dimerization interface [polypeptide binding]; other site
216595003920	active site
216595003922	PS00190 Cytochrome c family heme-binding site signature.
216595003924	Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
216595003926	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
216595003927	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
216595003928	amidase catalytic site [active]
216595003929	Zn binding residues [ion binding]; other site
216595003930	substrate binding site [chemical binding]; other site
216595003932	Membrane protein required for beta-lactamase induction [Defense mechanisms]; Region: AmpE; cl17896
216595003933	5 probable transmembrane helices predicted for PFLU0799 by TMHMM2.0 at aa 45-67, 72-94, 146-168, 192-214 and 255-277
216595003934	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
216595003935	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595003936	dimerization interface [polypeptide binding]; other site
216595003937	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595003938	dimer interface [polypeptide binding]; other site
216595003939	putative CheW interface [polypeptide binding]; other site
216595003940	2 probable transmembrane helices predicted for PFLU0800 by TMHMM2.0 at aa 15-37 and 325-347
216595003943	2 probable transmembrane helices predicted for PFLU0801 by TMHMM2.0 at aa 99-121 and 125-147
216595003944	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
216595003945	active site
216595003947	PS01137 Uncharacterized protein family UPF0006 signature 1.
216595003948	DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303
216595003949	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
216595003950	DNA binding site [nucleotide binding]
216595003951	domain linker motif; other site
216595003952	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
216595003953	dimerization interface [polypeptide binding]; other site
216595003954	ligand binding site [chemical binding]; other site
216595003957	PS00356 Bacterial regulatory proteins, lacI family signature.
216595003958	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109
216595003959	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
216595003960	active site
216595003961	phosphorylation site [posttranslational modification]
216595003962	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359
216595003963	active site
216595003964	phosphorylation site [posttranslational modification]
216595003965	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
216595003966	dimerization domain swap beta strand [polypeptide binding]; other site
216595003967	regulatory protein interface [polypeptide binding]; other site
216595003968	active site
216595003969	regulatory phosphorylation site [posttranslational modification]; other site
216595003970	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
216595003971	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
216595003972	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
216595003973	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
216595003975	PS00372 PTS EIIA domains phosphorylation site signature 2.
216595003980	PS00370 PEP-utilizing enzymes phosphorylation site signature.
216595003982	PS00742 PEP-utilizing enzymes signature 2.
216595003983	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
216595003984	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
216595003985	putative substrate binding site [chemical binding]; other site
216595003986	putative ATP binding site [chemical binding]; other site
216595003988	PS00583 pfkB family of carbohydrate kinases signature 1.
216595003989	PS00584 pfkB family of carbohydrate kinases signature 2.
216595003990	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
216595003991	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
216595003992	active site
216595003993	P-loop; other site
216595003994	phosphorylation site [posttranslational modification]
216595003995	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
216595003996	active site
216595003997	P-loop; other site
216595003998	phosphorylation site [posttranslational modification]
216595003999	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
216595004002	9 probable transmembrane helices predicted for PFLU0806 by TMHMM2.0 at aa 240-262, 282-299, 311-333, 353-375, 396-415, 435-457, 470-487, 492-514 and 534-556
216595004003	Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540
216595004004	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
216595004005	putative active site [active]
216595004006	putative metal binding site [ion binding]; other site
216595004007	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
216595004008	metallophosphoesterase, PPA1498 family; Region: P_acnes_RR; cl17623
216595004010	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
216595004011	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
216595004012	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
216595004013	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
216595004014	Flavodoxin; Region: Flavodoxin_1; pfam00258
216595004015	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
216595004016	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200
216595004017	FAD binding pocket [chemical binding]; other site
216595004018	FAD binding motif [chemical binding]; other site
216595004019	catalytic residues [active]
216595004020	NAD binding pocket [chemical binding]; other site
216595004021	phosphate binding motif [ion binding]; other site
216595004022	beta-alpha-beta structure motif; other site
216595004029	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
216595004030	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
216595004031	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
216595004032	active site
216595004033	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
216595004034	PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.
216595004036	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
216595004037	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
216595004038	dimer interface [polypeptide binding]; other site
216595004039	active site
216595004040	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
216595004041	catalytic residues [active]
216595004042	substrate binding site [chemical binding]; other site
216595004045	PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site.
216595004046	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
216595004047	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
216595004048	Walker A/P-loop; other site
216595004049	ATP binding site [chemical binding]; other site
216595004050	Q-loop/lid; other site
216595004051	ABC transporter signature motif; other site
216595004052	Walker B; other site
216595004053	D-loop; other site
216595004054	H-loop/switch region; other site
216595004055	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
216595004056	PS00017 ATP/GTP-binding site motif A (P-loop).
216595004059	PS00211 ABC transporters family signature.
216595004060	PS00017 ATP/GTP-binding site motif A (P-loop).
216595004061	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595004062	dimer interface [polypeptide binding]; other site
216595004063	conserved gate region; other site
216595004064	ABC-ATPase subunit interface; other site
216595004066	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595004067	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
216595004068	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
216595004070	PS00583 pfkB family of carbohydrate kinases signature 1.
216595004071	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595004072	dimer interface [polypeptide binding]; other site
216595004073	conserved gate region; other site
216595004074	putative PBP binding loops; other site
216595004075	ABC-ATPase subunit interface; other site
216595004077	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595004078	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595004079	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
216595004080	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
216595004081	G1 box; other site
216595004082	putative GEF interaction site [polypeptide binding]; other site
216595004083	GTP/Mg2+ binding site [chemical binding]; other site
216595004084	Switch I region; other site
216595004085	G2 box; other site
216595004086	G3 box; other site
216595004087	Switch II region; other site
216595004088	G4 box; other site
216595004089	G5 box; other site
216595004090	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
216595004092	PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature.
216595004093	PS00301 GTP-binding elongation factors signature.
216595004095	1 probable transmembrane helix predicted for PFLU0817 by TMHMM2.0 at aa 7-29
216595004096	1 probable transmembrane helix predicted for PFLU0818 by TMHMM2.0 at aa 7-26
216595004098	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
216595004099	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
216595004100	Walker A/P-loop; other site
216595004101	ATP binding site [chemical binding]; other site
216595004102	Q-loop/lid; other site
216595004103	ABC transporter signature motif; other site
216595004104	Walker B; other site
216595004105	D-loop; other site
216595004106	H-loop/switch region; other site
216595004107	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
216595004110	PS00211 ABC transporters family signature.
216595004111	PS00017 ATP/GTP-binding site motif A (P-loop).
216595004112	dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022
216595004113	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
216595004114	Walker A/P-loop; other site
216595004115	ATP binding site [chemical binding]; other site
216595004116	Q-loop/lid; other site
216595004117	ABC transporter signature motif; other site
216595004118	Walker B; other site
216595004119	D-loop; other site
216595004120	H-loop/switch region; other site
216595004121	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
216595004124	PS00211 ABC transporters family signature.
216595004125	PS00017 ATP/GTP-binding site motif A (P-loop).
216595004126	dipeptide transporter; Provisional; Region: PRK10913
216595004127	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
216595004128	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595004129	dimer interface [polypeptide binding]; other site
216595004130	conserved gate region; other site
216595004131	putative PBP binding loops; other site
216595004132	ABC-ATPase subunit interface; other site
216595004134	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
216595004135	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595004136	dimer interface [polypeptide binding]; other site
216595004137	conserved gate region; other site
216595004138	putative PBP binding loops; other site
216595004139	ABC-ATPase subunit interface; other site
216595004141	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595004142	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
216595004143	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
216595004144	peptide binding site [polypeptide binding]; other site
216595004146	outer membrane porin, OprD family; Region: OprD; pfam03573
216595004148	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
216595004149	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
216595004150	peptide binding site [polypeptide binding]; other site
216595004152	PS01040 Bacterial extracellular solute-binding proteins, family 5 signature.
216595004153	1 probable transmembrane helix predicted for PFLU0825 by TMHMM2.0 at aa 7-24
216595004154	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
216595004155	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
216595004156	peptide binding site [polypeptide binding]; other site
216595004158	PS01040 Bacterial extracellular solute-binding proteins, family 5 signature.
216595004159	1 probable transmembrane helix predicted for PFLU0826 by TMHMM2.0 at aa 12-34
216595004160	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
216595004161	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
216595004162	peptide binding site [polypeptide binding]; other site
216595004164	PS01040 Bacterial extracellular solute-binding proteins, family 5 signature.
216595004165	Protein of unknown function (DUF541); Region: SIMPL; cl01077
216595004166	Uncharacterized conserved protein [Function unknown]; Region: COG2968
216595004168	1 probable transmembrane helix predicted for PFLU0828 by TMHMM2.0 at aa 7-26
216595004169	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
216595004170	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595004171	ATP binding site [chemical binding]; other site
216595004172	G-X-G motif; other site
216595004173	5 probable transmembrane helices predicted for PFLU0829 by TMHMM2.0 at aa 70-92, 97-119, 139-161, 174-196 and 208-230
216595004176	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
216595004177	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595004178	active site
216595004179	phosphorylation site [posttranslational modification]
216595004180	intermolecular recognition site; other site
216595004181	dimerization interface [polypeptide binding]; other site
216595004182	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
216595004185	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
216595004186	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
216595004187	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
216595004189	5 probable transmembrane helices predicted for PFLU0831 by TMHMM2.0 at aa 38-60, 80-102, 158-180, 185-207 and 281-303
216595004191	PS00017 ATP/GTP-binding site motif A (P-loop).
216595004192	PS00211 ABC transporters family signature.
216595004193	Protein of unknown function (DUF1043); Region: DUF1043; cl11473
216595004195	1 probable transmembrane helix predicted for PFLU0832 by TMHMM2.0 at aa 4-26
216595004196	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
216595004197	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
216595004198	tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284
216595004199	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
216595004200	active site
216595004201	HIGH motif; other site
216595004202	dimer interface [polypeptide binding]; other site
216595004203	KMSKS motif; other site
216595004205	Predicted ATPase [General function prediction only]; Region: COG1485
216595004207	PS00017 ATP/GTP-binding site motif A (P-loop).
216595004208	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
216595004209	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
216595004210	conserved cys residue [active]
216595004211	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595004212	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595004214	PS00041 Bacterial regulatory proteins, araC family signature.
216595004216	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
216595004217	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
216595004218	active site
216595004221	PS00072 Acyl-CoA dehydrogenases signature 1.
216595004223	PS00073 Acyl-CoA dehydrogenases signature 2.
216595004224	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
216595004225	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
216595004226	active site
216595004227	catalytic tetrad [active]
216595004229	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
216595004230	23S rRNA interface [nucleotide binding]; other site
216595004231	L3 interface [polypeptide binding]; other site
216595004233	PS00783 Ribosomal protein L13 signature.
216595004234	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
216595004236	PS00360 Ribosomal protein S9 signature.
216595004237	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
216595004238	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
216595004239	[2Fe-2S] cluster binding site [ion binding]; other site
216595004240	1 probable transmembrane helix predicted for PFLU0841 by TMHMM2.0 at aa 13-35
216595004242	PS00199 Rieske iron-sulfur protein signature 1.
216595004243	PS00200 Rieske iron-sulfur protein signature 2.
216595004244	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
216595004245	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
216595004246	Qi binding site; other site
216595004247	intrachain domain interface; other site
216595004248	interchain domain interface [polypeptide binding]; other site
216595004249	heme bH binding site [chemical binding]; other site
216595004250	heme bL binding site [chemical binding]; other site
216595004251	Qo binding site; other site
216595004252	interchain domain interface [polypeptide binding]; other site
216595004253	intrachain domain interface; other site
216595004254	Qi binding site; other site
216595004255	Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032
216595004256	Qo binding site; other site
216595004258	9 probable transmembrane helices predicted for PFLU0842 by TMHMM2.0 at aa 34-56, 83-105, 118-140, 145-164, 185-207, 246-263, 308-327, 344-363 and 370-392
216595004260	Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857
216595004261	PS00190 Cytochrome c family heme-binding site signature.
216595004262	1 probable transmembrane helix predicted for PFLU0843 by TMHMM2.0 at aa 232-250
216595004263	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
216595004264	stringent starvation protein A; Provisional; Region: sspA; PRK09481
216595004265	C-terminal domain interface [polypeptide binding]; other site
216595004266	putative GSH binding site (G-site) [chemical binding]; other site
216595004267	dimer interface [polypeptide binding]; other site
216595004268	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
216595004269	dimer interface [polypeptide binding]; other site
216595004270	N-terminal domain interface [polypeptide binding]; other site
216595004273	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
216595004275	Transcriptional regulators [Transcription]; Region: FadR; COG2186
216595004276	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595004277	DNA-binding site [nucleotide binding]; DNA binding site
216595004278	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
216595004281	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
216595004282	5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
216595004283	putative active site [active]
216595004284	catalytic residue [active]
216595004286	Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
216595004287	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
216595004288	NAD(P) binding site [chemical binding]; other site
216595004289	catalytic residues [active]
216595004291	PS00687 Aldehyde dehydrogenases glutamic acid active site.
216595004292	PS00070 Aldehyde dehydrogenases cysteine active site.
216595004293	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595004294	D-galactonate transporter; Region: 2A0114; TIGR00893
216595004295	putative substrate translocation pore; other site
216595004296	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595004297	12 probable transmembrane helices predicted for PFLU0851 by TMHMM2.0 at aa 12-34, 49-71, 78-97, 102-124, 145-167, 171-193, 247-269, 284-303, 316-338, 343-365, 378-400 and 410-429
216595004299	galactarate dehydratase; Region: galactar-dH20; TIGR03248
216595004300	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
216595004301	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
216595004304	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
216595004305	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
216595004306	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
216595004307	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
216595004308	putative acyl-acceptor binding pocket; other site
216595004309	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
216595004310	Predicted permeases [General function prediction only]; Region: COG0679
216595004311	10 probable transmembrane helices predicted for PFLU0856 by TMHMM2.0 at aa 4-26, 39-58, 68-90, 103-122, 132-154, 166-188, 198-220, 227-249, 253-275 and 284-306
216595004313	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
216595004315	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
216595004316	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
216595004317	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
216595004320	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
216595004321	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
216595004323	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595004325	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
216595004326	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
216595004327	GatB domain; Region: GatB_Yqey; smart00845
216595004331	PS01234 PET112 family signature.
216595004332	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
216595004333	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
216595004335	PS00571 Amidases signature.
216595004336	PS00017 ATP/GTP-binding site motif A (P-loop).
216595004337	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
216595004339	rod shape-determining protein MreB; Provisional; Region: PRK13927
216595004340	MreB and similar proteins; Region: MreB_like; cd10225
216595004341	nucleotide binding site [chemical binding]; other site
216595004342	Mg binding site [ion binding]; other site
216595004343	putative protofilament interaction site [polypeptide binding]; other site
216595004344	RodZ interaction site [polypeptide binding]; other site
216595004346	rod shape-determining protein MreC; Provisional; Region: PRK13922
216595004347	rod shape-determining protein MreC; Region: MreC; pfam04085
216595004348	1 probable transmembrane helix predicted for PFLU0864 by TMHMM2.0 at aa 5-24
216595004350	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
216595004352	4 probable transmembrane helices predicted for PFLU0865 by TMHMM2.0 at aa 9-31, 69-91, 104-126 and 130-152
216595004353	Maf-like protein; Region: Maf; pfam02545
216595004354	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
216595004355	active site
216595004356	dimer interface [polypeptide binding]; other site
216595004358	ribonuclease G; Provisional; Region: PRK11712
216595004359	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
216595004360	homodimer interface [polypeptide binding]; other site
216595004361	oligonucleotide binding site [chemical binding]; other site
216595004363	TIGR02099 family protein; Region: TIGR02099
216595004364	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
216595004365	2 probable transmembrane helices predicted for PFLU0868 by TMHMM2.0 at aa 7-29 and 1215-1234
216595004366	PS00041 Bacterial regulatory proteins, araC family signature.
216595004367	nitrilase; Region: PLN02798
216595004368	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
216595004369	putative active site [active]
216595004370	catalytic triad [active]
216595004371	dimer interface [polypeptide binding]; other site
216595004373	PS01227 Uncharacterized protein family UPF0012 signature.
216595004374	protease TldD; Provisional; Region: tldD; PRK10735
216595004376	peptidase PmbA; Provisional; Region: PRK11040
216595004378	fumarate hydratase; Reviewed; Region: fumC; PRK00485
216595004379	Class II fumarases; Region: Fumarase_classII; cd01362
216595004380	active site
216595004381	tetramer interface [polypeptide binding]; other site
216595004383	PS00163 Fumarate lyases signature.
216595004384	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
216595004385	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
216595004386	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
216595004389	PS00088 Manganese and iron superoxide dismutases signature.
216595004390	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
216595004391	ZIP Zinc transporter; Region: Zip; pfam02535
216595004392	9 probable transmembrane helices predicted for PFLU0877 by TMHMM2.0 at aa 13-35, 45-67, 79-101, 111-130, 156-178, 188-210, 217-239, 244-266 and 279-296
216595004394	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
216595004395	dimerization domain swap beta strand [polypeptide binding]; other site
216595004396	regulatory protein interface [polypeptide binding]; other site
216595004397	active site
216595004398	regulatory phosphorylation site [posttranslational modification]; other site
216595004400	PS00369 PTS HPR component histidine phosphorylation site signature.
216595004401	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
216595004402	AAA domain; Region: AAA_33; pfam13671
216595004404	PS00017 ATP/GTP-binding site motif A (P-loop).
216595004405	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
216595004406	active site
216595004407	phosphorylation site [posttranslational modification]
216595004409	PS00372 PTS EIIA domains phosphorylation site signature 2.
216595004410	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
216595004411	30S subunit binding site; other site
216595004413	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
216595004414	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
216595004415	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
216595004416	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
216595004418	PS00718 Sigma-54 factors family signature 2.
216595004419	PS00717 Sigma-54 factors family signature 1.
216595004422	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
216595004423	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
216595004424	Walker A/P-loop; other site
216595004425	ATP binding site [chemical binding]; other site
216595004426	Q-loop/lid; other site
216595004427	ABC transporter signature motif; other site
216595004428	Walker B; other site
216595004429	D-loop; other site
216595004430	H-loop/switch region; other site
216595004432	PS00211 ABC transporters family signature.
216595004433	PS00017 ATP/GTP-binding site motif A (P-loop).
216595004434	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
216595004435	OstA-like protein; Region: OstA; pfam03968
216595004437	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117
216595004438	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
216595004440	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
216595004441	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216595004442	active site
216595004443	motif I; other site
216595004444	motif II; other site
216595004446	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
216595004447	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
216595004448	putative active site [active]
216595004449	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
216595004452	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
216595004453	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
216595004454	Walker A/P-loop; other site
216595004455	ATP binding site [chemical binding]; other site
216595004456	Q-loop/lid; other site
216595004457	ABC transporter signature motif; other site
216595004458	Walker B; other site
216595004459	D-loop; other site
216595004460	H-loop/switch region; other site
216595004462	PS00017 ATP/GTP-binding site motif A (P-loop).
216595004463	PS00211 ABC transporters family signature.
216595004464	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
216595004465	Permease; Region: Permease; cl00510
216595004466	5 probable transmembrane helices predicted for PFLU0889 by TMHMM2.0 at aa 12-34, 54-76, 152-174, 201-223 and 243-262
216595004468	mce related protein; Region: MCE; pfam02470
216595004469	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
216595004470	2 probable transmembrane helices predicted for PFLU0890 by TMHMM2.0 at aa 7-29 and 49-71
216595004472	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
216595004474	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
216595004475	anti sigma factor interaction site; other site
216595004476	regulatory phosphorylation site [posttranslational modification]; other site
216595004478	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
216595004480	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
216595004481	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
216595004482	hinge; other site
216595004483	active site
216595004485	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
216595004486	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
216595004488	PS01316 ATP phosphoribosyltransferase signature.
216595004489	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
216595004490	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
216595004491	NAD binding site [chemical binding]; other site
216595004492	dimerization interface [polypeptide binding]; other site
216595004493	product binding site; other site
216595004494	substrate binding site [chemical binding]; other site
216595004495	zinc binding site [ion binding]; other site
216595004496	catalytic residues [active]
216595004498	PS00017 ATP/GTP-binding site motif A (P-loop).
216595004499	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
216595004500	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216595004501	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595004502	homodimer interface [polypeptide binding]; other site
216595004503	catalytic residue [active]
216595004505	PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site.
216595004506	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
216595004508	PS01116 Xanthine/uracil permeases family signature.
216595004509	PS00017 ATP/GTP-binding site motif A (P-loop).
216595004510	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
216595004511	active site
216595004513	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
216595004514	active site
216595004516	PS00213 Lipocalin signature.
216595004517	cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366
216595004518	malate:quinone oxidoreductase; Reviewed; Region: PRK13339
216595004519	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
216595004521	1 probable transmembrane helix predicted for PFLU0904 by TMHMM2.0 at aa 7-24
216595004522	hypothetical protein; Provisional; Region: PRK11627
216595004523	Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923
216595004524	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595004525	2 probable transmembrane helices predicted for PFLU0910 by TMHMM2.0 at aa 4-26 and 63-82
216595004526	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595004527	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
216595004528	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
216595004529	putative acyl-acceptor binding pocket; other site
216595004531	Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255
216595004532	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
216595004533	Uncharacterized conserved protein [Function unknown]; Region: COG2135
216595004535	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595004536	dimerization interface [polypeptide binding]; other site
216595004537	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
216595004538	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595004539	dimer interface [polypeptide binding]; other site
216595004540	putative CheW interface [polypeptide binding]; other site
216595004543	Peptidase family M48; Region: Peptidase_M48; pfam01435
216595004544	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595004546	PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.
216595004547	Predicted membrane protein [Function unknown]; Region: COG2119
216595004548	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
216595004549	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
216595004551	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
216595004552	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
216595004553	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595004554	S-adenosylmethionine binding site [chemical binding]; other site
216595004556	PS00092 N-6 Adenine-specific DNA methylases signature.
216595004558	glycerate dehydrogenase; Provisional; Region: PRK06487
216595004559	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
216595004560	putative ligand binding site [chemical binding]; other site
216595004561	putative NAD binding site [chemical binding]; other site
216595004562	catalytic site [active]
216595004565	PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3.
216595004566	LysE type translocator; Region: LysE; cl00565
216595004567	5 probable transmembrane helices predicted for PFLU0921 by TMHMM2.0 at aa 24-46, 82-104, 152-174, 184-206 and 219-241
216595004569	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
216595004570	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
216595004571	acyl-activating enzyme (AAE) consensus motif; other site
216595004572	AMP binding site [chemical binding]; other site
216595004573	active site
216595004574	CoA binding site [chemical binding]; other site
216595004576	Protein of unknown function (DUF1302); Region: DUF1302; pfam06980
216595004578	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
216595004580	PS00904 Protein prenyltransferases alpha subunit repeat signature.
216595004582	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
216595004583	AAA ATPase domain; Region: AAA_16; pfam13191
216595004584	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216595004585	DNA binding residues [nucleotide binding]
216595004586	dimerization interface [polypeptide binding]; other site
216595004587	PS00017 ATP/GTP-binding site motif A (P-loop).
216595004589	PS00622 Bacterial regulatory proteins, luxR family signature.
216595004590	Protein of unknown function (DUF330); Region: DUF330; pfam03886
216595004592	PS00430 TonB-dependent receptor proteins signature 1.
216595004593	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595004594	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
216595004595	mce related protein; Region: MCE; pfam02470
216595004596	mce related protein; Region: MCE; pfam02470
216595004597	mce related protein; Region: MCE; pfam02470
216595004601	1 probable transmembrane helix predicted for PFLU0927 by TMHMM2.0 at aa 26-48
216595004602	Paraquat-inducible protein A; Region: PqiA; pfam04403
216595004604	Paraquat-inducible protein A; Region: PqiA; pfam04403
216595004606	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
216595004608	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
216595004609	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
216595004610	ligand binding site [chemical binding]; other site
216595004612	PS01068 OmpA-like domain.
216595004613	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
216595004614	BON domain; Region: BON; pfam04972
216595004617	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595004618	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
216595004619	dimer interface [polypeptide binding]; other site
216595004620	active site
216595004622	LppC putative lipoprotein; Region: LppC; pfam04348
216595004623	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
216595004624	putative ligand binding site [chemical binding]; other site
216595004626	PS00041 Bacterial regulatory proteins, araC family signature.
216595004627	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595004628	Predicted methyltransferases [General function prediction only]; Region: COG0313
216595004629	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
216595004630	putative SAM binding site [chemical binding]; other site
216595004631	putative homodimer interface [polypeptide binding]; other site
216595004633	PS01296 Uncharacterized protein family UPF0011 signature.
216595004634	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
216595004635	MraZ protein; Region: MraZ; pfam02381
216595004636	MraZ protein; Region: MraZ; pfam02381
216595004639	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
216595004640	MraW methylase family; Region: Methyltransf_5; cl17771
216595004642	Cell division protein FtsL; Region: FtsL; pfam04999
216595004644	1 probable transmembrane helix predicted for PFLU0940 by TMHMM2.0 at aa 10-32
216595004645	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
216595004646	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
216595004647	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
216595004648	1 probable transmembrane helix predicted for PFLU0941 by TMHMM2.0 at aa 13-32
216595004651	PS00017 ATP/GTP-binding site motif A (P-loop).
216595004652	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
216595004653	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
216595004654	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
216595004655	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
216595004659	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
216595004660	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
216595004661	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
216595004662	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
216595004666	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
216595004667	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
216595004668	Mg++ binding site [ion binding]; other site
216595004669	putative catalytic motif [active]
216595004670	putative substrate binding site [chemical binding]; other site
216595004671	10 probable transmembrane helices predicted for PFLU0944 by TMHMM2.0 at aa 21-43, 71-90, 97-114, 134-156, 168-185, 200-222, 229-251, 261-283, 288-310 and 338-357
216595004673	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803
216595004674	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
216595004676	PS00012 Phosphopantetheine attachment site.
216595004678	cell division protein FtsW; Region: ftsW; TIGR02614
216595004679	PS01039 Bacterial extracellular solute-binding proteins, family 3 signature.
216595004681	10 probable transmembrane helices predicted for PFLU0946 by TMHMM2.0 at aa 26-48, 63-85, 90-110, 125-147, 159-176, 180-202, 204-226, 289-311, 323-345 and 355-377
216595004682	PS00428 Cell cycle proteins ftsW / rodA / spoVE signature.
216595004683	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
216595004684	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
216595004685	active site
216595004686	homodimer interface [polypeptide binding]; other site
216595004689	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
216595004690	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
216595004691	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
216595004692	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
216595004694	1 probable transmembrane helix predicted for PFLU0948 by TMHMM2.0 at aa 21-43
216595004697	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
216595004698	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
216595004699	ATP-grasp domain; Region: ATP-grasp_4; cl17255
216595004701	PS00017 ATP/GTP-binding site motif A (P-loop).
216595004702	PS00843 D-alanine--D-alanine ligase signature 1.
216595004704	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
216595004705	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
216595004706	Cell division protein FtsQ; Region: FtsQ; pfam03799
216595004707	1 probable transmembrane helix predicted for PFLU0950 by TMHMM2.0 at aa 39-61
216595004710	cell division protein FtsA; Region: ftsA; TIGR01174
216595004711	Cell division protein FtsA; Region: FtsA; smart00842
216595004712	Cell division protein FtsA; Region: FtsA; pfam14450
216595004715	cell division protein FtsZ; Validated; Region: PRK09330
216595004716	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
216595004717	nucleotide binding site [chemical binding]; other site
216595004718	SulA interaction site; other site
216595004720	PS01134 FtsZ protein signature 1.
216595004721	PS01135 FtsZ protein signature 2.
216595004723	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
216595004724	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
216595004727	PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a...; Region: PLA2_like; cl05417
216595004728	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
216595004729	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216595004730	metal binding site [ion binding]; metal-binding site
216595004731	active site
216595004732	I-site; other site
216595004734	outer membrane porin, OprD family; Region: OprD; pfam03573
216595004736	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
216595004737	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
216595004738	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595004739	dimer interface [polypeptide binding]; other site
216595004740	phosphorylation site [posttranslational modification]
216595004741	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595004742	ATP binding site [chemical binding]; other site
216595004743	Mg2+ binding site [ion binding]; other site
216595004744	G-X-G motif; other site
216595004748	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
216595004749	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595004750	active site
216595004751	phosphorylation site [posttranslational modification]
216595004752	intermolecular recognition site; other site
216595004753	dimerization interface [polypeptide binding]; other site
216595004754	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216595004755	DNA binding site [nucleotide binding]
216595004758	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
216595004760	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
216595004761	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
216595004762	HlyD family secretion protein; Region: HlyD_3; pfam13437
216595004764	1 probable transmembrane helix predicted for PFLU0961 by TMHMM2.0 at aa 31-48
216595004765	PS00583 pfkB family of carbohydrate kinases signature 1.
216595004766	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
216595004767	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595004768	substrate binding pocket [chemical binding]; other site
216595004769	membrane-bound complex binding site; other site
216595004770	hinge residues; other site
216595004772	Flagellin N-methylase; Region: FliB; pfam03692
216595004774	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
216595004776	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
216595004777	Response regulator receiver domain; Region: Response_reg; pfam00072
216595004778	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595004779	active site
216595004780	phosphorylation site [posttranslational modification]
216595004781	intermolecular recognition site; other site
216595004782	dimerization interface [polypeptide binding]; other site
216595004785	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
216595004786	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
216595004787	dimerization interface [polypeptide binding]; other site
216595004788	ligand binding site [chemical binding]; other site
216595004789	NADP binding site [chemical binding]; other site
216595004790	catalytic site [active]
216595004793	PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3.
216595004794	PS00017 ATP/GTP-binding site motif A (P-loop).
216595004795	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595004796	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595004797	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
216595004798	putative effector binding pocket; other site
216595004799	dimerization interface [polypeptide binding]; other site
216595004802	PS00044 Bacterial regulatory proteins, lysR family signature.
216595004803	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
216595004804	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595004807	Fusaric acid resistance protein family; Region: FUSC; pfam04632
216595004808	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
216595004809	11 probable transmembrane helices predicted for PFLU0971 by TMHMM2.0 at aa 30-52, 79-101, 106-123, 130-149, 159-181, 393-415, 420-439, 446-468, 473-492, 497-514 and 529-548
216595004811	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
216595004813	2 probable transmembrane helices predicted for PFLU0972 by TMHMM2.0 at aa 7-29 and 42-64
216595004814	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
216595004815	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
216595004816	HlyD family secretion protein; Region: HlyD_3; pfam13437
216595004817	1 probable transmembrane helix predicted for PFLU0973 by TMHMM2.0 at aa 4-26
216595004819	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460
216595004820	short chain dehydrogenase; Provisional; Region: PRK05693
216595004821	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
216595004822	NADP binding site [chemical binding]; other site
216595004823	active site
216595004824	steroid binding site; other site
216595004826	PS00061 Short-chain dehydrogenases/reductases family signature.
216595004827	ggaaccnnnnnnnnnnnnnnnnccacnna
216595004828	ggaaccnnnnnnnnnnnnnnnnccacnna
216595004829	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
216595004830	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
216595004831	Substrate binding site; other site
216595004832	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
216595004835	Alginate O-acetyl transferase AlgF; Region: AlgF; pfam11182
216595004836	1 probable transmembrane helix predicted for PFLU0980 by TMHMM2.0 at aa 13-35
216595004837	1 probable transmembrane helix predicted for PFLU0981 by TMHMM2.0 at aa 7-25
216595004838	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
216595004840	Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cd00244
216595004841	active site
216595004843	Right handed beta helix region; Region: Beta_helix; pfam13229
216595004844	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
216595004845	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
216595004848	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595004849	PilZ domain; Region: PilZ; pfam07238
216595004850	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
216595004851	HlyD family secretion protein; Region: HlyD_3; pfam13437
216595004852	1 probable transmembrane helix predicted for PFLU0988 by TMHMM2.0 at aa 158-177
216595004854	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
216595004855	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
216595004856	nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026
216595004857	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
216595004858	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
216595004859	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
216595004862	PS00290 Immunoglobulins and major histocompatibility complex proteins signature.
216595004864	hypothetical protein; Validated; Region: PRK02101
216595004866	PS00225 Crystallins beta and gamma 'Greek key' motif signature.
216595004867	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
216595004868	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
216595004869	NodB motif; other site
216595004870	active site
216595004871	catalytic site [active]
216595004872	metal binding site [ion binding]; metal-binding site
216595004874	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
216595004875	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
216595004876	putative active site [active]
216595004877	PhoH-like protein; Region: PhoH; pfam02562
216595004879	PS00017 ATP/GTP-binding site motif A (P-loop).
216595004880	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
216595004881	trimer interface [polypeptide binding]; other site
216595004882	dimer interface [polypeptide binding]; other site
216595004883	putative active site [active]
216595004885	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
216595004886	MoaE interaction surface [polypeptide binding]; other site
216595004887	MoeB interaction surface [polypeptide binding]; other site
216595004888	thiocarboxylated glycine; other site
216595004890	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
216595004891	MoaE homodimer interface [polypeptide binding]; other site
216595004892	MoaD interaction [polypeptide binding]; other site
216595004893	active site residues [active]
216595004895	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
216595004896	DEAD-like helicases superfamily; Region: DEXDc; smart00487
216595004897	ATP binding site [chemical binding]; other site
216595004898	Mg++ binding site [ion binding]; other site
216595004899	motif III; other site
216595004900	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
216595004901	nucleotide binding region [chemical binding]; other site
216595004902	ATP-binding site [chemical binding]; other site
216595004905	PS00039 DEAD-box subfamily ATP-dependent helicases signature.
216595004906	PS00017 ATP/GTP-binding site motif A (P-loop).
216595004907	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
216595004908	putative hydrolase; Provisional; Region: PRK11460
216595004910	PS00237 G-protein coupled receptors signature.
216595004911	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595004912	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
216595004913	substrate binding pocket [chemical binding]; other site
216595004914	membrane-bound complex binding site; other site
216595004915	hinge residues; other site
216595004916	1 probable transmembrane helix predicted for PFLU1000 by TMHMM2.0 at aa 7-29
216595004917	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
216595004918	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595004919	conserved gate region; other site
216595004920	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595004921	dimer interface [polypeptide binding]; other site
216595004922	ABC-ATPase subunit interface; other site
216595004923	putative PBP binding loops; other site
216595004924	8 probable transmembrane helices predicted for PFLU1001 by TMHMM2.0 at aa 21-40, 87-109, 130-152, 182-204, 217-239, 254-276, 333-352 and 362-384
216595004926	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595004927	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595004928	dimer interface [polypeptide binding]; other site
216595004929	conserved gate region; other site
216595004930	putative PBP binding loops; other site
216595004931	ABC-ATPase subunit interface; other site
216595004932	8 probable transmembrane helices predicted for PFLU1002 by TMHMM2.0 at aa 35-57, 97-116, 123-145, 155-177, 198-220, 230-249, 289-311 and 326-348
216595004934	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595004935	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
216595004936	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
216595004937	Walker A/P-loop; other site
216595004938	ATP binding site [chemical binding]; other site
216595004939	Q-loop/lid; other site
216595004940	ABC transporter signature motif; other site
216595004941	Walker B; other site
216595004942	D-loop; other site
216595004943	H-loop/switch region; other site
216595004945	PS00017 ATP/GTP-binding site motif A (P-loop).
216595004946	PS00211 ABC transporters family signature.
216595004947	putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830
216595004948	YgiT-type zinc finger domain; Region: YgiT_finger; TIGR03831
216595004949	Motility quorum-sensing regulator (MqsR); Region: MqsR; cd12869
216595004950	peptide binding site [polypeptide binding]; other site
216595004951	Transcriptional regulators [Transcription]; Region: FadR; COG2186
216595004952	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595004953	DNA-binding site [nucleotide binding]; DNA binding site
216595004954	FCD domain; Region: FCD; pfam07729
216595004956	PS00043 Bacterial regulatory proteins, gntR family signature.
216595004958	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595004959	cyanate transporter; Region: CynX; TIGR00896
216595004960	putative substrate translocation pore; other site
216595004961	12 probable transmembrane helices predicted for PFLU1007 by TMHMM2.0 at aa 37-59, 74-96, 103-122, 127-149, 161-180, 190-212, 233-255, 270-292, 299-321, 325-347, 354-376 and 391-413
216595004963	Protein of unknown function (DUF1120); Region: DUF1120; cl05856
216595004965	hypothetical protein; Provisional; Region: PRK15301
216595004966	Protein of unknown function (DUF1120); Region: DUF1120; cl05856
216595004968	PS00017 ATP/GTP-binding site motif A (P-loop).
216595004969	putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304
216595004970	PapC N-terminal domain; Region: PapC_N; pfam13954
216595004971	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
216595004972	PapC C-terminal domain; Region: PapC_C; pfam13953
216595004974	PS01151 Fimbrial biogenesis outer membrane usher protein signature.
216595004975	putative fimbrial chaperone protein; Provisional; Region: PRK09918
216595004976	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
216595004977	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
216595004980	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595004981	Protein of unknown function (DUF1120); Region: DUF1120; cl05856
216595004983	Protein of unknown function (DUF1120); Region: DUF1120; cl05856
216595004985	Protein of unknown function (DUF1120); Region: DUF1120; cl05856
216595004987	Protein of unknown function (DUF1120); Region: DUF1120; cl05856
216595004989	Protein of unknown function (DUF1120); Region: DUF1120; cl05856
216595004991	Response regulator receiver domain; Region: Response_reg; pfam00072
216595004992	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595004993	active site
216595004994	phosphorylation site [posttranslational modification]
216595004995	intermolecular recognition site; other site
216595004996	dimerization interface [polypeptide binding]; other site
216595004999	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
216595005000	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595005001	active site
216595005002	phosphorylation site [posttranslational modification]
216595005003	intermolecular recognition site; other site
216595005004	dimerization interface [polypeptide binding]; other site
216595005005	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216595005006	DNA binding residues [nucleotide binding]
216595005007	dimerization interface [polypeptide binding]; other site
216595005010	SnoaL-like domain; Region: SnoaL_3; pfam13474
216595005011	SnoaL-like domain; Region: SnoaL_2; pfam12680
216595005013	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
216595005014	GIY-YIG motif/motif A; other site
216595005015	putative active site [active]
216595005016	putative metal binding site [ion binding]; other site
216595005018	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
216595005019	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
216595005020	C-terminal domain interface [polypeptide binding]; other site
216595005021	GSH binding site (G-site) [chemical binding]; other site
216595005022	dimer interface [polypeptide binding]; other site
216595005023	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
216595005024	N-terminal domain interface [polypeptide binding]; other site
216595005025	Secretin and TonB N terminus short domain; Region: STN; smart00965
216595005026	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
216595005027	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216595005028	N-terminal plug; other site
216595005029	ligand-binding site [chemical binding]; other site
216595005033	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
216595005034	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595005036	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
216595005037	Transcriptional regulator [Transcription]; Region: IclR; COG1414
216595005038	Bacterial transcriptional regulator; Region: IclR; pfam01614
216595005041	homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341
216595005043	fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266
216595005044	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
216595005045	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
216595005048	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
216595005049	maleylacetoacetate isomerase; Region: maiA; TIGR01262
216595005050	C-terminal domain interface [polypeptide binding]; other site
216595005051	GSH binding site (G-site) [chemical binding]; other site
216595005052	putative dimer interface [polypeptide binding]; other site
216595005053	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
216595005054	N-terminal domain interface [polypeptide binding]; other site
216595005055	dimer interface [polypeptide binding]; other site
216595005056	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
216595005058	benzoate transport; Region: 2A0115; TIGR00895
216595005059	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595005060	putative substrate translocation pore; other site
216595005061	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595005062	12 probable transmembrane helices predicted for PFLU1028 by TMHMM2.0 at aa 22-44, 59-78, 90-109, 114-136, 149-171, 176-198, 259-278, 293-315, 324-343, 353-375, 388-410 and 414-431
216595005064	Uncharacterized conserved protein [Function unknown]; Region: COG2912
216595005065	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
216595005066	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
216595005067	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
216595005068	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
216595005069	NAD binding site [chemical binding]; other site
216595005070	Phe binding site; other site
216595005073	YebG protein; Region: YebG; pfam07130
216595005075	Predicted membrane protein [Function unknown]; Region: COG3223
216595005077	4 probable transmembrane helices predicted for PFLU1032 by TMHMM2.0 at aa 30-52, 62-79, 86-103 and 113-135
216595005078	Protein of unknown function (DUF3509); Region: DUF3509; pfam12021
216595005079	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
216595005080	serine transporter; Region: stp; TIGR00814
216595005081	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
216595005082	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
216595005083	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
216595005086	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595005087	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
216595005088	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
216595005089	dimerization interface [polypeptide binding]; other site
216595005090	substrate binding pocket [chemical binding]; other site
216595005092	PS00290 Immunoglobulins and major histocompatibility complex proteins signature.
216595005094	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250
216595005095	30S subunit binding site; other site
216595005096	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595005097	putative substrate translocation pore; other site
216595005099	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595005100	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595005101	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475
216595005102	putative effector binding pocket; other site
216595005103	putative dimerization interface [polypeptide binding]; other site
216595005105	PS00044 Bacterial regulatory proteins, lysR family signature.
216595005107	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
216595005108	Secretin and TonB N terminus short domain; Region: STN; smart00965
216595005109	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216595005110	N-terminal plug; other site
216595005111	ligand-binding site [chemical binding]; other site
216595005113	PS01156 TonB-dependent receptor proteins signature 2.
216595005116	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
216595005117	FecR protein; Region: FecR; pfam04773
216595005119	RNA polymerase sigma factor; Provisional; Region: PRK12528
216595005120	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
216595005121	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
216595005122	DNA binding residues [nucleotide binding]
216595005125	Protein of unknown function (DUF3649); Region: DUF3649; pfam12365
216595005126	3 probable transmembrane helices predicted for PFLU1043 by TMHMM2.0 at aa 31-53, 58-80 and 87-109
216595005127	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
216595005128	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
216595005129	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
216595005131	8 probable transmembrane helices predicted for PFLU1044 by TMHMM2.0 at aa 12-34, 141-163, 190-212, 342-364, 385-404, 419-436, 443-465 and 480-499
216595005135	Protein of unknown function (DUF3325); Region: DUF3325; pfam11804
216595005136	3 probable transmembrane helices predicted for PFLU1045 by TMHMM2.0 at aa 37-59, 63-81 and 88-107
216595005137	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
216595005138	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
216595005139	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
216595005140	DNA binding residues [nucleotide binding]
216595005143	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
216595005144	FecR protein; Region: FecR; pfam04773
216595005145	1 probable transmembrane helix predicted for PFLU1047 by TMHMM2.0 at aa 86-108
216595005147	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
216595005148	catalytic residues [active]
216595005150	PS00194 Thioredoxin family active site.
216595005151	Nucleoid-associated protein [General function prediction only]; Region: COG3081
216595005152	nucleoid-associated protein NdpA; Validated; Region: PRK00378
216595005154	PS00847 MCM family signature.
216595005155	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
216595005156	IHF - DNA interface [nucleotide binding]; other site
216595005157	IHF dimer interface [polypeptide binding]; other site
216595005159	Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971
216595005160	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595005161	S-adenosylmethionine binding site [chemical binding]; other site
216595005163	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
216595005164	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
216595005165	HIGH motif; other site
216595005166	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
216595005167	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
216595005168	active site
216595005169	KMSKS motif; other site
216595005170	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
216595005171	tRNA binding surface [nucleotide binding]; other site
216595005172	anticodon binding site; other site
216595005173	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
216595005176	PS00178 Aminoacyl-transfer RNA synthetases class-I signature.
216595005177	DNA polymerase III subunit chi; Validated; Region: PRK05728
216595005179	multifunctional aminopeptidase A; Provisional; Region: PRK00913
216595005180	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
216595005181	interface (dimer of trimers) [polypeptide binding]; other site
216595005182	Substrate-binding/catalytic site; other site
216595005183	Zn-binding sites [ion binding]; other site
216595005185	PS00631 Cytosol aminopeptidase signature.
216595005187	PS00017 ATP/GTP-binding site motif A (P-loop).
216595005188	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
216595005189	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
216595005191	6 probable transmembrane helices predicted for PFLU1056 by TMHMM2.0 at aa 13-35, 61-80, 101-123, 276-298, 305-327 and 337-359
216595005192	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
216595005193	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
216595005195	6 probable transmembrane helices predicted for PFLU1057 by TMHMM2.0 at aa 7-29, 63-85, 98-120, 238-260, 273-295 and 333-355
216595005196	PS00107 Protein kinases ATP-binding region signature.
216595005197	GTP-binding protein LepA; Provisional; Region: PRK05433
216595005198	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
216595005199	G1 box; other site
216595005200	putative GEF interaction site [polypeptide binding]; other site
216595005201	GTP/Mg2+ binding site [chemical binding]; other site
216595005202	Switch I region; other site
216595005203	G2 box; other site
216595005204	G3 box; other site
216595005205	Switch II region; other site
216595005206	G4 box; other site
216595005207	G5 box; other site
216595005208	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
216595005209	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
216595005210	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
216595005212	PS00017 ATP/GTP-binding site motif A (P-loop).
216595005216	signal peptidase I; Provisional; Region: PRK10861
216595005217	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
216595005218	Catalytic site [active]
216595005219	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
216595005220	2 probable transmembrane helices predicted for PFLU1059 by TMHMM2.0 at aa 5-27 and 59-81
216595005222	PS00501 Signal peptidases I serine active site.
216595005223	PS00760 Signal peptidases I lysine active site.
216595005224	PS00761 Signal peptidases I signature 3.
216595005225	ribonuclease III; Reviewed; Region: rnc; PRK00102
216595005226	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
216595005227	dimerization interface [polypeptide binding]; other site
216595005228	active site
216595005229	metal binding site [ion binding]; metal-binding site
216595005230	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
216595005231	dsRNA binding site [nucleotide binding]; other site
216595005233	PS00517 Ribonuclease III family signature.
216595005235	GTPase Era; Reviewed; Region: era; PRK00089
216595005236	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
216595005237	G1 box; other site
216595005238	GTP/Mg2+ binding site [chemical binding]; other site
216595005239	Switch I region; other site
216595005240	G2 box; other site
216595005241	Switch II region; other site
216595005242	G3 box; other site
216595005243	G4 box; other site
216595005244	G5 box; other site
216595005245	KH domain; Region: KH_2; pfam07650
216595005247	PS00017 ATP/GTP-binding site motif A (P-loop).
216595005249	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
216595005250	Recombination protein O N terminal; Region: RecO_N; pfam11967
216595005251	Recombination protein O C terminal; Region: RecO_C; pfam02565
216595005253	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
216595005254	active site
216595005255	hydrophilic channel; other site
216595005256	dimerization interface [polypeptide binding]; other site
216595005257	catalytic residues [active]
216595005258	active site lid [active]
216595005260	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
216595005261	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
216595005262	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
216595005263	1 probable transmembrane helix predicted for PFLU1064 by TMHMM2.0 at aa 31-53
216595005266	PS00017 ATP/GTP-binding site motif A (P-loop).
216595005267	PS00079 Multicopper oxidases signature 1.
216595005268	PS00080 Multicopper oxidases signature 2.
216595005269	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
216595005270	nucleoside/Zn binding site; other site
216595005271	dimer interface [polypeptide binding]; other site
216595005272	catalytic motif [active]
216595005274	PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature.
216595005275	Methyltransferase domain; Region: Methyltransf_31; pfam13847
216595005276	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595005277	S-adenosylmethionine binding site [chemical binding]; other site
216595005279	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595005280	S-adenosylmethionine binding site [chemical binding]; other site
216595005282	YhhN-like protein; Region: YhhN; pfam07947
216595005284	Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394
216595005285	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595005286	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
216595005287	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595005288	Walker A motif; other site
216595005289	ATP binding site [chemical binding]; other site
216595005290	Walker B motif; other site
216595005291	arginine finger; other site
216595005292	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
216595005294	PS01046 ATP-dependent serine proteases, lon family, serine active site.
216595005296	PS00017 ATP/GTP-binding site motif A (P-loop).
216595005298	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595005299	DNA-binding site [nucleotide binding]; DNA binding site
216595005300	Transcriptional regulators [Transcription]; Region: GntR; COG1802
216595005301	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595005302	DNA-binding site [nucleotide binding]; DNA binding site
216595005303	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
216595005307	PS00043 Bacterial regulatory proteins, gntR family signature.
216595005308	hypothetical protein; Provisional; Region: PRK06102
216595005309	Amidase; Region: Amidase; cl11426
216595005311	PS00017 ATP/GTP-binding site motif A (P-loop).
216595005312	PS00571 Amidases signature.
216595005313	Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938
216595005314	active site
216595005315	catalytic site [active]
216595005316	Zn binding site [ion binding]; other site
216595005317	tetramer interface [polypeptide binding]; other site
216595005318	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
216595005320	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595005321	benzoate transport; Region: 2A0115; TIGR00895
216595005322	putative substrate translocation pore; other site
216595005323	10 probable transmembrane helices predicted for PFLU1074 by TMHMM2.0 at aa 33-55, 70-92, 165-187, 191-210, 269-291, 306-328, 335-357, 361-383, 395-417 and 427-449
216595005325	PS00216 Sugar transport proteins signature 1.
216595005326	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595005327	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
216595005328	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216595005329	NAD(P) binding site [chemical binding]; other site
216595005330	active site
216595005332	PS00061 Short-chain dehydrogenases/reductases family signature.
216595005333	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216595005334	2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316
216595005335	NAD(P) binding site [chemical binding]; other site
216595005336	active site
216595005338	PS00061 Short-chain dehydrogenases/reductases family signature.
216595005339	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
216595005340	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
216595005341	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
216595005343	PS00017 ATP/GTP-binding site motif A (P-loop).
216595005345	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
216595005347	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595005348	dimerization interface [polypeptide binding]; other site
216595005349	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216595005350	metal binding site [ion binding]; metal-binding site
216595005351	active site
216595005352	I-site; other site
216595005353	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
216595005357	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595005358	dimerization interface [polypeptide binding]; other site
216595005359	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
216595005360	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216595005361	metal binding site [ion binding]; metal-binding site
216595005362	active site
216595005363	I-site; other site
216595005364	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
216595005365	2 probable transmembrane helices predicted for PFLU1083 by TMHMM2.0 at aa 15-37 and 286-308
216595005369	Protein of unknown function (DUF3034); Region: DUF3034; pfam11231
216595005370	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
216595005371	apolar tunnel; other site
216595005372	heme binding site [chemical binding]; other site
216595005373	dimerization interface [polypeptide binding]; other site
216595005374	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595005376	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
216595005377	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
216595005378	Trp docking motif [polypeptide binding]; other site
216595005379	putative active site [active]
216595005386	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
216595005387	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216595005388	N-terminal plug; other site
216595005389	ligand-binding site [chemical binding]; other site
216595005392	Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905
216595005393	6 probable transmembrane helices predicted for PFLU1088 by TMHMM2.0 at aa 5-23, 38-60, 72-94, 104-126, 139-157 and 177-199
216595005394	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
216595005395	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
216595005396	FAD binding pocket [chemical binding]; other site
216595005397	FAD binding motif [chemical binding]; other site
216595005398	phosphate binding motif [ion binding]; other site
216595005399	NAD binding pocket [chemical binding]; other site
216595005402	Predicted transcriptional regulators [Transcription]; Region: COG1695
216595005403	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
216595005405	PFI-2
216595005406	putative fimbria biosynthesis-related CDS cluster
216595005407	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
216595005409	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
216595005411	putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284
216595005412	PapC N-terminal domain; Region: PapC_N; pfam13954
216595005413	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
216595005414	PapC C-terminal domain; Region: PapC_C; pfam13953
216595005416	PS01151 Fimbrial biogenesis outer membrane usher protein signature.
216595005417	putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285
216595005418	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
216595005419	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
216595005421	PS00635 Gram-negative pili assembly chaperone signature.
216595005423	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
216595005425	Fimbrial protein; Region: Fimbrial; cl01416
216595005426	Fimbrial protein; Region: Fimbrial; cl01416
216595005427	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
216595005429	Fimbrial protein; Region: Fimbrial; pfam00419
216595005430	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
216595005431	Transglycosylase; Region: Transgly; pfam00912
216595005432	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
216595005433	1 probable transmembrane helix predicted for PFLU1101 by TMHMM2.0 at aa 37-54
216595005434	PS00017 ATP/GTP-binding site motif A (P-loop).
216595005435	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
216595005436	Spore germination protein; Region: Spore_permease; cl17796
216595005438	12 probable transmembrane helices predicted for PFLU1103 by TMHMM2.0 at aa 41-60, 64-86, 119-141, 146-165, 177-199, 219-241, 262-284, 304-326, 357-375, 379-401, 422-444 and 449-471
216595005439	PS00218 Amino acid permeases signature.
216595005440	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
216595005441	Leucine rich repeat; Region: LRR_8; pfam13855
216595005442	Substrate binding site [chemical binding]; other site
216595005443	Leucine rich repeat; Region: LRR_8; pfam13855
216595005447	OpgC protein; Region: OpgC_C; pfam10129
216595005448	Acyltransferase family; Region: Acyl_transf_3; pfam01757
216595005449	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
216595005450	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
216595005451	active site
216595005452	FMN binding site [chemical binding]; other site
216595005453	substrate binding site [chemical binding]; other site
216595005454	3Fe-4S cluster binding site [ion binding]; other site
216595005456	1 probable transmembrane helix predicted for PFLU1107 by TMHMM2.0 at aa 5-27
216595005457	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
216595005459	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
216595005461	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
216595005462	addiction module antidote protein, HigA family; Region: antidote_HigA; TIGR02607
216595005464	Response regulator receiver domain; Region: Response_reg; pfam00072
216595005465	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595005466	active site
216595005467	phosphorylation site [posttranslational modification]
216595005468	intermolecular recognition site; other site
216595005469	dimerization interface [polypeptide binding]; other site
216595005470	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595005471	dimer interface [polypeptide binding]; other site
216595005472	phosphorylation site [posttranslational modification]
216595005473	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595005474	ATP binding site [chemical binding]; other site
216595005475	Mg2+ binding site [ion binding]; other site
216595005476	G-X-G motif; other site
216595005480	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
216595005481	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595005482	ATP binding site [chemical binding]; other site
216595005483	Mg2+ binding site [ion binding]; other site
216595005484	G-X-G motif; other site
216595005486	cytochrome c-550; Provisional; Region: psbV; cl17239
216595005487	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
216595005488	PS00190 Cytochrome c family heme-binding site signature.
216595005489	PS00290 Immunoglobulins and major histocompatibility complex proteins signature.
216595005491	PS00190 Cytochrome c family heme-binding site signature.
216595005492	Response regulator receiver domain; Region: Response_reg; pfam00072
216595005493	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595005494	active site
216595005495	phosphorylation site [posttranslational modification]
216595005496	intermolecular recognition site; other site
216595005497	dimerization interface [polypeptide binding]; other site
216595005498	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
216595005499	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216595005500	metal binding site [ion binding]; metal-binding site
216595005501	active site
216595005502	I-site; other site
216595005503	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
216595005505	PS00017 ATP/GTP-binding site motif A (P-loop).
216595005508	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
216595005509	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595005510	active site
216595005511	phosphorylation site [posttranslational modification]
216595005512	intermolecular recognition site; other site
216595005513	dimerization interface [polypeptide binding]; other site
216595005514	HD domain; Region: HD_5; pfam13487
216595005516	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
216595005517	nudix motif; other site
216595005519	PS00893 mutT domain signature.
216595005520	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
216595005521	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216595005522	Coenzyme A binding pocket [chemical binding]; other site
216595005523	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
216595005525	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
216595005526	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595005527	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
216595005528	putative dimerization interface [polypeptide binding]; other site
216595005531	PS00044 Bacterial regulatory proteins, lysR family signature.
216595005532	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
216595005533	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
216595005535	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
216595005536	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
216595005537	catalytic residues [active]
216595005539	Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011
216595005540	active site
216595005541	metal binding site [ion binding]; metal-binding site
216595005542	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
216595005543	4 probable transmembrane helices predicted for PFLU1123 by TMHMM2.0 at aa 5-27, 39-61, 76-98 and 105-124
216595005544	4 probable transmembrane helices predicted for PFLU1124 by TMHMM2.0 at aa 13-35, 55-77, 84-106 and 110-129
216595005546	Fatty acid desaturase; Region: FA_desaturase; pfam00487
216595005547	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
216595005548	putative di-iron ligands [ion binding]; other site
216595005550	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
216595005552	1 probable transmembrane helix predicted for PFLU1126 by TMHMM2.0 at aa 13-32
216595005553	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
216595005554	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
216595005555	4-aminobutyrate aminotransferase; Provisional; Region: PRK08360
216595005556	inhibitor-cofactor binding pocket; inhibition site
216595005557	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595005558	catalytic residue [active]
216595005560	PS01159 WW/rsp5/WWP domain signature.
216595005561	PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site.
216595005562	Esterase/lipase [General function prediction only]; Region: COG1647
216595005563	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
216595005564	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595005565	dimerization interface [polypeptide binding]; other site
216595005566	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595005567	dimer interface [polypeptide binding]; other site
216595005568	phosphorylation site [posttranslational modification]
216595005569	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595005570	ATP binding site [chemical binding]; other site
216595005571	Mg2+ binding site [ion binding]; other site
216595005572	G-X-G motif; other site
216595005573	1 probable transmembrane helix predicted for PFLU1131 by TMHMM2.0 at aa 24-46
216595005577	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
216595005578	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595005579	active site
216595005580	phosphorylation site [posttranslational modification]
216595005581	intermolecular recognition site; other site
216595005582	dimerization interface [polypeptide binding]; other site
216595005583	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595005584	Walker A motif; other site
216595005585	ATP binding site [chemical binding]; other site
216595005586	Walker B motif; other site
216595005587	arginine finger; other site
216595005588	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
216595005591	PS00675 Sigma-54 interaction domain ATP-binding region A signature.
216595005592	PS00676 Sigma-54 interaction domain ATP-binding region B signature.
216595005593	PS00688 Sigma-54 interaction domain C-terminal part signature.
216595005595	GlpM protein; Region: GlpM; pfam06942
216595005597	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
216595005598	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595005599	active site
216595005600	phosphorylation site [posttranslational modification]
216595005601	intermolecular recognition site; other site
216595005602	dimerization interface [polypeptide binding]; other site
216595005603	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595005604	Walker A motif; other site
216595005605	ATP binding site [chemical binding]; other site
216595005606	Walker B motif; other site
216595005607	arginine finger; other site
216595005608	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
216595005610	PS00688 Sigma-54 interaction domain C-terminal part signature.
216595005612	PS00676 Sigma-54 interaction domain ATP-binding region B signature.
216595005613	PS00675 Sigma-54 interaction domain ATP-binding region A signature.
216595005615	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
216595005616	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595005617	dimer interface [polypeptide binding]; other site
216595005618	phosphorylation site [posttranslational modification]
216595005619	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595005620	ATP binding site [chemical binding]; other site
216595005621	Mg2+ binding site [ion binding]; other site
216595005622	G-X-G motif; other site
216595005625	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
216595005626	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
216595005627	Walker A/P-loop; other site
216595005628	ATP binding site [chemical binding]; other site
216595005629	Q-loop/lid; other site
216595005630	ABC transporter signature motif; other site
216595005631	Walker B; other site
216595005632	D-loop; other site
216595005633	H-loop/switch region; other site
216595005635	PS00211 ABC transporters family signature.
216595005636	PS00017 ATP/GTP-binding site motif A (P-loop).
216595005637	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
216595005638	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595005639	dimer interface [polypeptide binding]; other site
216595005640	conserved gate region; other site
216595005641	putative PBP binding loops; other site
216595005642	ABC-ATPase subunit interface; other site
216595005644	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595005645	dimer interface [polypeptide binding]; other site
216595005646	conserved gate region; other site
216595005647	putative PBP binding loops; other site
216595005648	ABC-ATPase subunit interface; other site
216595005650	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
216595005651	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595005652	substrate binding pocket [chemical binding]; other site
216595005653	membrane-bound complex binding site; other site
216595005654	hinge residues; other site
216595005656	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
216595005657	PS00978 FAD-dependent glycerol-3-phosphate dehydrogenase signature 2.
216595005659	PS00977 FAD-dependent glycerol-3-phosphate dehydrogenase signature 1.
216595005660	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
216595005661	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
216595005662	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
216595005665	PS00894 Bacterial regulatory proteins, deoR family signature.
216595005666	glycerol kinase; Provisional; Region: glpK; PRK00047
216595005667	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
216595005668	N- and C-terminal domain interface [polypeptide binding]; other site
216595005669	active site
216595005670	MgATP binding site [chemical binding]; other site
216595005671	catalytic site [active]
216595005672	metal binding site [ion binding]; metal-binding site
216595005673	glycerol binding site [chemical binding]; other site
216595005674	homotetramer interface [polypeptide binding]; other site
216595005675	homodimer interface [polypeptide binding]; other site
216595005676	protein IIAGlc interface [polypeptide binding]; other site
216595005678	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595005679	PS00445 FGGY family of carbohydrate kinases signature 2.
216595005680	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595005682	PS00933 FGGY family of carbohydrate kinases signature 1.
216595005683	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
216595005684	amphipathic channel; other site
216595005685	Asn-Pro-Ala signature motifs; other site
216595005687	PS00221 MIP family signature.
216595005688	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
216595005689	putative deacylase active site [active]
216595005691	PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature.
216595005692	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
216595005693	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
216595005694	Walker A/P-loop; other site
216595005695	ATP binding site [chemical binding]; other site
216595005696	Q-loop/lid; other site
216595005697	ABC transporter signature motif; other site
216595005698	Walker B; other site
216595005699	D-loop; other site
216595005700	H-loop/switch region; other site
216595005701	TOBE domain; Region: TOBE_2; pfam08402
216595005704	PS00211 ABC transporters family signature.
216595005705	PS00017 ATP/GTP-binding site motif A (P-loop).
216595005706	ornithine carbamoyltransferase; Provisional; Region: PRK00779
216595005707	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
216595005708	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
216595005711	PS00097 Aspartate and ornithine carbamoyltransferases signature.
216595005712	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
216595005713	The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762
216595005714	putative [Fe4-S4] binding site [ion binding]; other site
216595005715	putative molybdopterin cofactor binding site [chemical binding]; other site
216595005716	The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782
216595005717	putative molybdopterin cofactor binding site; other site
216595005722	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
216595005723	putative GSH binding site [chemical binding]; other site
216595005724	catalytic residues [active]
216595005726	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
216595005727	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
216595005728	heme binding site [chemical binding]; other site
216595005729	ferroxidase pore; other site
216595005730	ferroxidase diiron center [ion binding]; other site
216595005732	PS00549 Bacterioferritin signature.
216595005733	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
216595005735	peroxidase; Provisional; Region: PRK15000
216595005736	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
216595005737	dimer interface [polypeptide binding]; other site
216595005738	decamer (pentamer of dimers) interface [polypeptide binding]; other site
216595005739	catalytic triad [active]
216595005740	peroxidatic and resolving cysteines [active]
216595005743	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
216595005744	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
216595005745	dimer interface [polypeptide binding]; other site
216595005746	catalytic site [active]
216595005747	putative active site [active]
216595005748	putative substrate binding site [chemical binding]; other site
216595005750	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
216595005751	active site
216595005752	substrate binding pocket [chemical binding]; other site
216595005753	dimer interface [polypeptide binding]; other site
216595005755	PS00483 Dihydroorotase signature 2.
216595005756	PS00482 Dihydroorotase signature 1.
216595005757	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
216595005758	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
216595005759	ligand binding site [chemical binding]; other site
216595005761	argininosuccinate synthase; Provisional; Region: PRK13820
216595005762	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
216595005763	ANP binding site [chemical binding]; other site
216595005764	Substrate Binding Site II [chemical binding]; other site
216595005765	Substrate Binding Site I [chemical binding]; other site
216595005767	PS00564 Argininosuccinate synthase signature 1.
216595005768	PS00565 Argininosuccinate synthase signature 2.
216595005769	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
216595005770	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595005771	active site
216595005772	phosphorylation site [posttranslational modification]
216595005773	intermolecular recognition site; other site
216595005774	dimerization interface [polypeptide binding]; other site
216595005775	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216595005776	DNA binding residues [nucleotide binding]
216595005777	dimerization interface [polypeptide binding]; other site
216595005780	PS00622 Bacterial regulatory proteins, luxR family signature.
216595005781	endonuclease III; Provisional; Region: PRK10702
216595005782	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
216595005783	minor groove reading motif; other site
216595005784	helix-hairpin-helix signature motif; other site
216595005785	substrate binding pocket [chemical binding]; other site
216595005786	active site
216595005787	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
216595005788	PS00764 Endonuclease III iron-sulfur binding region signature.
216595005791	ferredoxin; Provisional; Region: PRK08764
216595005792	Putative Fe-S cluster; Region: FeS; pfam04060
216595005793	4Fe-4S binding domain; Region: Fer4; pfam00037
216595005795	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
216595005797	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
216595005799	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
216595005800	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
216595005801	active site
216595005802	HIGH motif; other site
216595005803	KMSKS motif; other site
216595005804	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
216595005805	tRNA binding surface [nucleotide binding]; other site
216595005806	anticodon binding site; other site
216595005807	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
216595005808	dimer interface [polypeptide binding]; other site
216595005809	putative tRNA-binding site [nucleotide binding]; other site
216595005812	PS00178 Aminoacyl-transfer RNA synthetases class-I signature.
216595005813	antiporter inner membrane protein; Provisional; Region: PRK11670
216595005814	Domain of unknown function DUF59; Region: DUF59; pfam01883
216595005815	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
216595005817	PS01118 Translation initiation factor SUI1 signature.
216595005818	PS00017 ATP/GTP-binding site motif A (P-loop).
216595005819	PS01215 Mrp family signature.
216595005820	Ferredoxin [Energy production and conversion]; Region: COG1146
216595005821	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
216595005823	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
216595005825	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
216595005826	MutS domain I; Region: MutS_I; pfam01624
216595005827	MutS domain II; Region: MutS_II; pfam05188
216595005828	MutS domain III; Region: MutS_III; pfam05192
216595005829	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
216595005830	Walker A/P-loop; other site
216595005831	ATP binding site [chemical binding]; other site
216595005832	Q-loop/lid; other site
216595005833	ABC transporter signature motif; other site
216595005834	Walker B; other site
216595005835	D-loop; other site
216595005836	H-loop/switch region; other site
216595005838	PS00486 DNA mismatch repair proteins mutS family signature.
216595005839	PS00017 ATP/GTP-binding site motif A (P-loop).
216595005843	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595005845	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
216595005846	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
216595005847	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216595005848	non-specific DNA binding site [nucleotide binding]; other site
216595005849	salt bridge; other site
216595005850	sequence-specific DNA binding site [nucleotide binding]; other site
216595005851	Predicted transcriptional regulator [Transcription]; Region: COG2932
216595005852	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
216595005853	Catalytic site [active]
216595005856	Prophage 1
216595005857	3 probable transmembrane helices predicted for PFLU1169 by TMHMM2.0 at aa 10-32, 45-67 and 71-93
216595005858	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595005859	Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812
216595005861	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
216595005862	Baseplate J-like protein; Region: Baseplate_J; cl01294
216595005864	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684
216595005865	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
216595005866	Phage Tail Collar Domain; Region: Collar; pfam07484
216595005867	Phage Tail Collar Domain; Region: Collar; pfam07484
216595005870	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
216595005871	Phage tail tube protein FII; Region: Phage_tube; cl01390
216595005872	PS00017 ATP/GTP-binding site motif A (P-loop).
216595005873	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
216595005874	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
216595005875	Phage P2 GpU; Region: Phage_P2_GpU; cl01391
216595005877	Phage Tail Protein X; Region: Phage_tail_X; cl02088
216595005879	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
216595005881	Predicted chitinase [General function prediction only]; Region: COG3179
216595005882	catalytic residue [active]
216595005884	Bacteriophage lysis protein; Region: Phage_lysis; pfam03245
216595005885	Competence-damaged protein; Region: CinA; cl00666
216595005887	recombinase A; Provisional; Region: recA; PRK09354
216595005888	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
216595005889	hexamer interface [polypeptide binding]; other site
216595005890	Walker A motif; other site
216595005891	ATP binding site [chemical binding]; other site
216595005892	Walker B motif; other site
216595005894	PS00017 ATP/GTP-binding site motif A (P-loop).
216595005895	PS00321 recA signature.
216595005896	recombination regulator RecX; Reviewed; Region: recX; PRK00117
216595005898	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
216595005900	Domain of unknown function (DUF4146); Region: DUF4146; pfam13652
216595005901	Uncharacterized conserved protein [Function unknown]; Region: COG3148
216595005903	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
216595005904	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595005905	active site
216595005906	phosphorylation site [posttranslational modification]
216595005907	intermolecular recognition site; other site
216595005908	dimerization interface [polypeptide binding]; other site
216595005909	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216595005910	DNA binding residues [nucleotide binding]
216595005911	dimerization interface [polypeptide binding]; other site
216595005914	PS00622 Bacterial regulatory proteins, luxR family signature.
216595005915	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
216595005917	3 probable transmembrane helices predicted for PFLU1196 by TMHMM2.0 at aa 36-57, 64-86 and 106-123
216595005918	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
216595005919	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595005920	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
216595005921	putative dimerization interface [polypeptide binding]; other site
216595005924	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
216595005925	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
216595005926	FAD binding pocket [chemical binding]; other site
216595005927	FAD binding motif [chemical binding]; other site
216595005928	phosphate binding motif [ion binding]; other site
216595005929	beta-alpha-beta structure motif; other site
216595005930	NAD binding pocket [chemical binding]; other site
216595005933	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
216595005934	homodimer interaction site [polypeptide binding]; other site
216595005935	cofactor binding site; other site
216595005937	PS01318 Uncharacterized protein family UPF0066 signature.
216595005938	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
216595005939	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
216595005940	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
216595005943	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
216595005944	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
216595005945	RNA binding surface [nucleotide binding]; other site
216595005946	Pseudouridine synthase, a subgroup of the RsuA family; Region: PSSA_1; cd02555
216595005947	active site
216595005949	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
216595005950	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216595005951	Coenzyme A binding pocket [chemical binding]; other site
216595005953	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
216595005954	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
216595005955	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216595005956	FeS/SAM binding site; other site
216595005957	TRAM domain; Region: TRAM; cl01282
216595005959	PS01278 Uncharacterized protein family UPF0004 signature.
216595005961	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
216595005962	potassium uptake protein; Region: kup; TIGR00794
216595005963	12 probable transmembrane helices predicted for PFLU1204 by TMHMM2.0 at aa 20-42, 57-76, 113-135, 150-169, 181-203, 223-245, 258-280, 295-317, 349-368, 378-400, 407-426 and 431-448
216595005965	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
216595005966	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
216595005967	active site
216595005968	FMN binding site [chemical binding]; other site
216595005969	substrate binding site [chemical binding]; other site
216595005970	homotetramer interface [polypeptide binding]; other site
216595005971	catalytic residue [active]
216595005973	Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131
216595005974	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
216595005976	1 probable transmembrane helix predicted for PFLU1207 by TMHMM2.0 at aa 12-31
216595005977	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
216595005979	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
216595005980	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
216595005981	tetrameric interface [polypeptide binding]; other site
216595005982	NAD binding site [chemical binding]; other site
216595005983	catalytic residues [active]
216595005984	substrate binding site [chemical binding]; other site
216595005986	PS00687 Aldehyde dehydrogenases glutamic acid active site.
216595005987	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
216595005988	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595005989	dimer interface [polypeptide binding]; other site
216595005990	conserved gate region; other site
216595005991	putative PBP binding loops; other site
216595005992	ABC-ATPase subunit interface; other site
216595005994	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595005995	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
216595005996	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595005997	dimer interface [polypeptide binding]; other site
216595005998	putative PBP binding loops; other site
216595005999	ABC-ATPase subunit interface; other site
216595006001	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595006002	PS00017 ATP/GTP-binding site motif A (P-loop).
216595006003	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
216595006004	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216595006005	Walker A/P-loop; other site
216595006006	ATP binding site [chemical binding]; other site
216595006007	Q-loop/lid; other site
216595006008	ABC transporter signature motif; other site
216595006009	Walker B; other site
216595006010	D-loop; other site
216595006011	H-loop/switch region; other site
216595006012	TOBE domain; Region: TOBE_2; pfam08402
216595006015	PS00211 ABC transporters family signature.
216595006016	PS00017 ATP/GTP-binding site motif A (P-loop).
216595006017	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
216595006018	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
216595006020	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
216595006021	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
216595006022	tetrameric interface [polypeptide binding]; other site
216595006023	NAD binding site [chemical binding]; other site
216595006024	catalytic residues [active]
216595006025	substrate binding site [chemical binding]; other site
216595006027	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595006028	PS00687 Aldehyde dehydrogenases glutamic acid active site.
216595006029	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595006030	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595006031	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
216595006032	putative substrate binding pocket [chemical binding]; other site
216595006033	dimerization interface [polypeptide binding]; other site
216595006036	PS00044 Bacterial regulatory proteins, lysR family signature.
216595006037	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979
216595006038	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
216595006039	putative metal binding site [ion binding]; other site
216595006040	2 probable transmembrane helices predicted for PFLU1216 by TMHMM2.0 at aa 43-65 and 85-102
216595006042	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
216595006043	PhoP regulatory network protein YrbL; Region: YrbL-PhoP_reg; cl17608
216595006045	PS00041 Bacterial regulatory proteins, araC family signature.
216595006046	wsp operon EMBL:AY074937
216595006047	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
216595006048	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595006049	dimerization interface [polypeptide binding]; other site
216595006050	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595006051	dimer interface [polypeptide binding]; other site
216595006052	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
216595006053	putative CheW interface [polypeptide binding]; other site
216595006054	2 probable transmembrane helices predicted for PFLU1219 by TMHMM2.0 at aa 10-29 and 192-214
216595006057	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
216595006059	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
216595006060	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
216595006061	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
216595006062	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
216595006063	binding surface
216595006064	Tetratricopeptide repeat; Region: TPR_16; pfam13432
216595006065	TPR motif; other site
216595006068	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
216595006070	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
216595006071	putative binding surface; other site
216595006072	active site
216595006073	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
216595006074	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595006075	ATP binding site [chemical binding]; other site
216595006076	Mg2+ binding site [ion binding]; other site
216595006077	G-X-G motif; other site
216595006078	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
216595006079	Response regulator receiver domain; Region: Response_reg; pfam00072
216595006080	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595006081	active site
216595006082	phosphorylation site [posttranslational modification]
216595006083	intermolecular recognition site; other site
216595006084	dimerization interface [polypeptide binding]; other site
216595006089	chemotaxis-specific methylesterase; Provisional; Region: PRK12555
216595006090	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595006091	active site
216595006092	phosphorylation site [posttranslational modification]
216595006093	intermolecular recognition site; other site
216595006094	CheB methylesterase; Region: CheB_methylest; pfam01339
216595006097	Response regulator receiver domain; Region: Response_reg; pfam00072
216595006098	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595006099	active site
216595006100	phosphorylation site [posttranslational modification]
216595006101	intermolecular recognition site; other site
216595006102	dimerization interface [polypeptide binding]; other site
216595006103	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
216595006104	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216595006105	metal binding site [ion binding]; metal-binding site
216595006106	active site
216595006107	I-site; other site
216595006112	PS00745 Prokaryotic-type class I peptide chain release factors signature.
216595006113	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595006114	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
216595006115	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
216595006116	dimer interface [polypeptide binding]; other site
216595006117	putative anticodon binding site; other site
216595006118	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
216595006119	motif 1; other site
216595006120	active site
216595006121	motif 2; other site
216595006122	motif 3; other site
216595006125	PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1.
216595006126	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
216595006127	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
216595006129	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595006130	Domain of unknown function (DUF1704); Region: DUF1704; cl06858
216595006132	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
216595006133	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
216595006134	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
216595006135	1 probable transmembrane helix predicted for PFLU1232 by TMHMM2.0 at aa 12-31
216595006137	1 probable transmembrane helix predicted for PFLU1233 by TMHMM2.0 at aa 7-29
216595006138	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595006139	1 probable transmembrane helix predicted for PFLU1234 by TMHMM2.0 at aa 13-35
216595006140	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
216595006141	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
216595006142	ligand binding site [chemical binding]; other site
216595006144	PS01068 OmpA-like domain.
216595006145	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595006146	Domain of unknown function (DUF4398); Region: DUF4398; pfam14346
216595006147	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
216595006148	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
216595006150	PS00781 Phosphoenolpyruvate carboxylase active site 1.
216595006151	PS00393 Phosphoenolpyruvate carboxylase active site 2.
216595006152	adenylate kinase; Reviewed; Region: adk; PRK00279
216595006153	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
216595006154	AMP-binding site [chemical binding]; other site
216595006155	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
216595006157	PS00113 Adenylate kinase signature.
216595006159	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
216595006160	Glycoprotease family; Region: Peptidase_M22; pfam00814
216595006162	Protein of unknown function DUF72; Region: DUF72; cl00777
216595006164	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
216595006165	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
216595006166	tetramer interface [polypeptide binding]; other site
216595006167	active site
216595006168	Mg2+/Mn2+ binding site [ion binding]; other site
216595006169	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
216595006170	2 probable transmembrane helices predicted for PFLU1246 by TMHMM2.0 at aa 7-26 and 95-117
216595006171	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595006173	Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517
216595006175	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
216595006176	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216595006177	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
216595006179	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
216595006180	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
216595006181	HlyD family secretion protein; Region: HlyD_3; pfam13437
216595006182	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595006184	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
216595006186	12 probable transmembrane helices predicted for PFLU1251 by TMHMM2.0 at aa 13-32, 336-355, 362-384, 388-407, 427-449, 464-486, 532-551, 865-882, 889-908, 912-934, 961-978 and 988-1010
216595006187	PS00589 PTS HPR component serine phosphorylation site signature.
216595006188	1 probable transmembrane helix predicted for PFLU1252 by TMHMM2.0 at aa 107-129
216595006189	Protein of unknown function (DUF4197); Region: DUF4197; pfam13852
216595006190	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126
216595006191	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595006192	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
216595006193	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
216595006194	putative acyl-acceptor binding pocket; other site
216595006196	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
216595006197	DNA-binding site [nucleotide binding]; DNA binding site
216595006198	RNA-binding motif; other site
216595006200	PS00352 'Cold-shock' DNA-binding domain signature.
216595006201	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
216595006202	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595006203	S-adenosylmethionine binding site [chemical binding]; other site
216595006205	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
216595006206	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
216595006207	metal binding site [ion binding]; metal-binding site
216595006208	dimer interface [polypeptide binding]; other site
216595006211	Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309
216595006212	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
216595006213	NdvC_like  proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase; Region: CESA_NdvC_like; cd06435
216595006214	Ligand binding site; other site
216595006215	DXD motif; other site
216595006216	Domain of unknown function (DUF4396); Region: DUF4396; pfam14342
216595006219	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
216595006220	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
216595006221	putative ATP binding site [chemical binding]; other site
216595006222	putative substrate interface [chemical binding]; other site
216595006224	PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature.
216595006225	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
216595006227	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
216595006228	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
216595006229	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
216595006230	catalytic residue [active]
216595006232	PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site.
216595006233	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536
216595006234	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
216595006235	putative trimer interface [polypeptide binding]; other site
216595006236	putative CoA binding site [chemical binding]; other site
216595006237	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
216595006238	ArsC family; Region: ArsC; pfam03960
216595006239	putative catalytic residues [active]
216595006241	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
216595006242	10 probable transmembrane helices predicted for PFLU1266 by TMHMM2.0 at aa 21-43, 58-80, 101-123, 128-150, 171-190, 194-216, 285-307, 331-353, 374-396 and 411-433
216595006244	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595006245	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
216595006246	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216595006247	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595006248	homodimer interface [polypeptide binding]; other site
216595006249	catalytic residue [active]
216595006251	PS00215 Mitochondrial energy transfer proteins signature.
216595006252	PS00215 Mitochondrial energy transfer proteins signature.
216595006253	PII uridylyl-transferase; Provisional; Region: glnD; PRK00275
216595006254	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
216595006255	metal binding triad; other site
216595006256	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
216595006257	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
216595006258	Zn2+ binding site [ion binding]; other site
216595006259	Mg2+ binding site [ion binding]; other site
216595006260	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
216595006261	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
216595006267	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
216595006268	active site
216595006270	PS00680 Methionine aminopeptidase subfamily 1 signature.
216595006271	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
216595006272	rRNA interaction site [nucleotide binding]; other site
216595006273	S8 interaction site; other site
216595006274	putative laminin-1 binding site; other site
216595006275	PS00962 Ribosomal protein S2 signature 1.
216595006277	PS00963 Ribosomal protein S2 signature 2.
216595006278	elongation factor Ts; Provisional; Region: tsf; PRK09377
216595006279	UBA/TS-N domain; Region: UBA; pfam00627
216595006280	Elongation factor TS; Region: EF_TS; pfam00889
216595006281	Elongation factor TS; Region: EF_TS; pfam00889
216595006283	PS01126 Elongation factor Ts signature 1.
216595006285	PS00017 ATP/GTP-binding site motif A (P-loop).
216595006286	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
216595006287	putative nucleotide binding site [chemical binding]; other site
216595006288	uridine monophosphate binding site [chemical binding]; other site
216595006289	homohexameric interface [polypeptide binding]; other site
216595006291	ribosome recycling factor; Reviewed; Region: frr; PRK00083
216595006292	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
216595006293	hinge region; other site
216595006295	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
216595006296	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
216595006297	catalytic residue [active]
216595006298	putative FPP diphosphate  binding site; other site
216595006299	putative FPP binding hydrophobic cleft; other site
216595006300	dimer interface [polypeptide binding]; other site
216595006301	putative IPP diphosphate binding site; other site
216595006303	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
216595006304	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
216595006306	8 probable transmembrane helices predicted for PFLU1275 by TMHMM2.0 at aa 5-23, 27-49, 56-73, 78-97, 104-126, 136-155, 176-198 and 202-219
216595006307	ggaaccnnnnnnnnnnnnnnnnccacnna
216595006308	PS01315 Phosphatidate cytidylyltransferase signature.
216595006309	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
216595006310	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
216595006311	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
216595006312	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
216595006315	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
216595006316	zinc metallopeptidase RseP; Provisional; Region: PRK10779
216595006317	active site
216595006318	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
216595006319	protein binding site [polypeptide binding]; other site
216595006320	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
216595006321	protein binding site [polypeptide binding]; other site
216595006322	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
216595006323	putative substrate binding region [chemical binding]; other site
216595006324	4 probable transmembrane helices predicted for PFLU1277 by TMHMM2.0 at aa 7-29, 97-119, 379-401 and 425-444
216595006326	PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.
216595006328	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
216595006329	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
216595006330	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
216595006331	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
216595006332	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
216595006333	Surface antigen; Region: Bac_surface_Ag; pfam01103
216595006340	periplasmic chaperone; Provisional; Region: PRK10780
216595006341	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
216595006343	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
216595006344	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
216595006345	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
216595006346	trimer interface [polypeptide binding]; other site
216595006347	active site
216595006348	UDP-GlcNAc binding site [chemical binding]; other site
216595006349	lipid binding site [chemical binding]; lipid-binding site
216595006352	PS00101 Hexapeptide-repeat containing-transferases signature.
216595006360	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
216595006362	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
216595006363	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
216595006364	active site
216595006365	PS00101 Hexapeptide-repeat containing-transferases signature.
216595006373	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
216595006374	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
216595006376	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
216595006377	RNA/DNA hybrid binding site [nucleotide binding]; other site
216595006378	active site
216595006380	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
216595006381	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
216595006382	putative active site [active]
216595006383	putative PHP Thumb interface [polypeptide binding]; other site
216595006384	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
216595006385	generic binding surface II; other site
216595006386	generic binding surface I; other site
216595006390	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
216595006391	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
216595006393	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
216595006394	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
216595006395	Ligand Binding Site [chemical binding]; other site
216595006396	TilS substrate binding domain; Region: TilS; pfam09179
216595006397	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
216595006400	CTP synthetase; Validated; Region: pyrG; PRK05380
216595006401	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
216595006402	Catalytic site [active]
216595006403	active site
216595006404	UTP binding site [chemical binding]; other site
216595006405	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
216595006406	active site
216595006407	putative oxyanion hole; other site
216595006408	catalytic triad [active]
216595006410	1 probable transmembrane helix predicted for PFLU1289 by TMHMM2.0 at aa 5-27
216595006412	PS00442 Glutamine amidotransferases class-I active site.
216595006413	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
216595006414	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
216595006416	enolase; Provisional; Region: eno; PRK00077
216595006417	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
216595006418	dimer interface [polypeptide binding]; other site
216595006419	metal binding site [ion binding]; metal-binding site
216595006420	substrate binding pocket [chemical binding]; other site
216595006423	PS00164 Enolase signature.
216595006424	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
216595006425	Septum formation initiator; Region: DivIC; cl17659
216595006426	1 probable transmembrane helix predicted for PFLU1292 by TMHMM2.0 at aa 27-46
216595006428	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
216595006429	substrate binding site; other site
216595006430	dimer interface; other site
216595006432	PS01295 Uncharacterized protein family UPF0007 signature.
216595006433	LysR family transcriptional regulator; Provisional; Region: PRK14997
216595006434	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595006435	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like_1; cd08470
216595006436	putative effector binding pocket; other site
216595006437	putative dimerization interface [polypeptide binding]; other site
216595006440	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
216595006441	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
216595006442	substrate binding site [chemical binding]; other site
216595006443	catalytic Zn binding site [ion binding]; other site
216595006444	NAD binding site [chemical binding]; other site
216595006445	structural Zn binding site [ion binding]; other site
216595006446	dimer interface [polypeptide binding]; other site
216595006449	S-formylglutathione hydrolase; Region: PLN02442
216595006450	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
216595006452	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
216595006453	homotrimer interaction site [polypeptide binding]; other site
216595006454	zinc binding site [ion binding]; other site
216595006455	CDP-binding sites; other site
216595006457	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
216595006458	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
216595006459	Permutation of conserved domain; other site
216595006460	active site
216595006461	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
216595006463	PS01268 Uncharacterized protein family UPF0024 signature.
216595006464	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
216595006466	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
216595006467	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595006468	S-adenosylmethionine binding site [chemical binding]; other site
216595006470	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
216595006471	PS01279 Protein-L-isoaspartate(D-aspartate) O-methyltransferase signature.
216595006472	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
216595006473	Peptidase family M23; Region: Peptidase_M23; pfam01551
216595006474	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595006477	RNA polymerase sigma factor RpoS; Validated; Region: PRK05657
216595006478	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
216595006479	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
216595006480	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
216595006481	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
216595006482	DNA binding residues [nucleotide binding]
216595006485	PS00715 Sigma-70 factors family signature 1.
216595006488	PS00716 Sigma-70 factors family signature 2.
216595006489	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
216595006490	DNA-binding site [nucleotide binding]; DNA binding site
216595006491	RNA-binding motif; other site
216595006493	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
216595006494	trimer interface [polypeptide binding]; other site
216595006495	active site
216595006497	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
216595006498	putative active site [active]
216595006499	putative metal binding site [ion binding]; other site
216595006501	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
216595006502	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
216595006503	ATP binding site [chemical binding]; other site
216595006504	putative Mg++ binding site [ion binding]; other site
216595006505	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
216595006506	nucleotide binding region [chemical binding]; other site
216595006507	ATP-binding site [chemical binding]; other site
216595006508	DEAD/H associated; Region: DEAD_assoc; pfam08494
216595006512	PS00017 ATP/GTP-binding site motif A (P-loop).
216595006513	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
216595006514	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
216595006515	Walker A/P-loop; other site
216595006516	ATP binding site [chemical binding]; other site
216595006517	Q-loop/lid; other site
216595006518	ABC transporter signature motif; other site
216595006519	Walker B; other site
216595006520	D-loop; other site
216595006521	H-loop/switch region; other site
216595006523	PS00211 ABC transporters family signature.
216595006524	PS00017 ATP/GTP-binding site motif A (P-loop).
216595006525	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
216595006526	active site
216595006527	Zn binding site [ion binding]; other site
216595006529	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595006530	dimer interface [polypeptide binding]; other site
216595006531	conserved gate region; other site
216595006532	putative PBP binding loops; other site
216595006533	ABC-ATPase subunit interface; other site
216595006535	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595006536	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
216595006537	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595006538	dimer interface [polypeptide binding]; other site
216595006539	conserved gate region; other site
216595006540	putative PBP binding loops; other site
216595006541	ABC-ATPase subunit interface; other site
216595006543	PS00017 ATP/GTP-binding site motif A (P-loop).
216595006544	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595006545	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
216595006546	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595006547	substrate binding pocket [chemical binding]; other site
216595006548	membrane-bound complex binding site; other site
216595006549	hinge residues; other site
216595006551	PS01039 Bacterial extracellular solute-binding proteins, family 3 signature.
216595006552	1 probable transmembrane helix predicted for PFLU1311 by TMHMM2.0 at aa 12-29
216595006553	ATP-dependent DNA ligase; Validated; Region: PRK09247
216595006554	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
216595006555	active site
216595006556	DNA binding site [nucleotide binding]
216595006557	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
216595006558	DNA binding site [nucleotide binding]
216595006561	PS00697 ATP-dependent DNA ligase AMP-binding site.
216595006562	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
216595006563	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
216595006564	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
216595006565	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
216595006566	active site
216595006568	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595006569	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
216595006570	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
216595006571	C-terminal domain interface [polypeptide binding]; other site
216595006572	GSH binding site (G-site) [chemical binding]; other site
216595006573	dimer interface [polypeptide binding]; other site
216595006574	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
216595006575	N-terminal domain interface [polypeptide binding]; other site
216595006576	putative dimer interface [polypeptide binding]; other site
216595006577	active site
216595006580	SEC-C motif; Region: SEC-C; pfam02810
216595006582	Late embryogenesis abundant protein; Region: LEA_2; pfam03168
216595006583	1 probable transmembrane helix predicted for PFLU1318 by TMHMM2.0 at aa 21-43
216595006584	hypothetical protein; Provisional; Region: PRK00183
216595006585	SEC-C motif; Region: SEC-C; pfam02810
216595006587	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
216595006588	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
216595006589	ligand binding site [chemical binding]; other site
216595006590	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595006592	Predicted integral membrane protein [Function unknown]; Region: COG5615
216595006593	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
216595006594	DEAD/DEAH box helicase; Region: DEAD; pfam00270
216595006595	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
216595006596	PS00017 ATP/GTP-binding site motif A (P-loop).
216595006597	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
216595006598	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
216595006599	Beta-lactamase; Region: Beta-lactamase; pfam00144
216595006601	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
216595006602	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
216595006603	ligand binding site [chemical binding]; other site
216595006605	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
216595006606	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
216595006607	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
216595006609	PS01064 Pyridoxamine 5'-phosphate oxidase signature.
216595006610	1 probable transmembrane helix predicted for PFLU1329 by TMHMM2.0 at aa 4-21
216595006611	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
216595006612	2 probable transmembrane helices predicted for PFLU1330 by TMHMM2.0 at aa 33-55 and 105-127
216595006613	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595006615	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560
216595006617	PS00017 ATP/GTP-binding site motif A (P-loop).
216595006618	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
216595006619	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
216595006620	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
216595006621	catalytic residue [active]
216595006623	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
216595006625	Predicted membrane protein [Function unknown]; Region: COG3650
216595006626	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595006627	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
216595006628	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
216595006629	putative NAD(P) binding site [chemical binding]; other site
216595006630	homodimer interface [polypeptide binding]; other site
216595006632	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595006633	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595006634	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
216595006635	putative effector binding pocket; other site
216595006636	dimerization interface [polypeptide binding]; other site
216595006639	Predicted membrane protein [Function unknown]; Region: COG2259
216595006641	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
216595006642	hypothetical protein; Provisional; Region: PRK05409
216595006644	Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048
216595006645	1 probable transmembrane helix predicted for PFLU1341 by TMHMM2.0 at aa 20-42
216595006646	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
216595006647	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
216595006648	Walker A/P-loop; other site
216595006649	ATP binding site [chemical binding]; other site
216595006650	Q-loop/lid; other site
216595006651	ABC transporter signature motif; other site
216595006652	Walker B; other site
216595006653	D-loop; other site
216595006654	H-loop/switch region; other site
216595006656	PS00211 ABC transporters family signature.
216595006657	PS00017 ATP/GTP-binding site motif A (P-loop).
216595006658	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
216595006659	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
216595006660	Walker A/P-loop; other site
216595006661	ATP binding site [chemical binding]; other site
216595006662	Q-loop/lid; other site
216595006663	ABC transporter signature motif; other site
216595006664	Walker B; other site
216595006665	D-loop; other site
216595006666	H-loop/switch region; other site
216595006668	PS00211 ABC transporters family signature.
216595006669	PS00017 ATP/GTP-binding site motif A (P-loop).
216595006670	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
216595006671	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
216595006672	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
216595006673	TM-ABC transporter signature motif; other site
216595006675	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
216595006676	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
216595006677	TM-ABC transporter signature motif; other site
216595006679	PS00044 Bacterial regulatory proteins, lysR family signature.
216595006680	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
216595006681	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
216595006682	dimerization interface [polypeptide binding]; other site
216595006683	ligand binding site [chemical binding]; other site
216595006685	Protein of unknown function (DUF2288); Region: DUF2288; pfam10052
216595006686	PS00605 ATP synthase c subunit signature.
216595006687	PS00227 Tubulin subunits alpha, beta, and gamma signature.
216595006688	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
216595006689	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
216595006690	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
216595006691	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
216595006692	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
216595006693	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216595006694	metal binding site [ion binding]; metal-binding site
216595006695	active site
216595006696	I-site; other site
216595006697	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
216595006703	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
216595006705	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595006706	putative substrate translocation pore; other site
216595006707	Major Facilitator Superfamily; Region: MFS_1; pfam07690
216595006708	12 probable transmembrane helices predicted for PFLU1351 by TMHMM2.0 at aa 13-35, 48-70, 83-105, 109-131, 138-160, 170-187, 212-234, 254-276, 289-307, 317-339, 352-374 and 404-426
216595006711	ATP-dependent helicase HepA; Validated; Region: PRK04914
216595006712	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
216595006713	ATP binding site [chemical binding]; other site
216595006714	putative Mg++ binding site [ion binding]; other site
216595006715	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
216595006716	nucleotide binding region [chemical binding]; other site
216595006717	ATP-binding site [chemical binding]; other site
216595006720	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
216595006721	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
216595006722	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
216595006723	catalytic residue [active]
216595006725	PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site.
216595006726	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
216595006727	homotrimer interaction site [polypeptide binding]; other site
216595006728	putative active site [active]
216595006730	PS00044 Bacterial regulatory proteins, lysR family signature.
216595006731	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
216595006732	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595006733	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
216595006734	dimerization interface [polypeptide binding]; other site
216595006735	substrate binding pocket [chemical binding]; other site
216595006738	PS00044 Bacterial regulatory proteins, lysR family signature.
216595006739	1 probable transmembrane helix predicted for PFLU1358 by TMHMM2.0 at aa 7-29
216595006740	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
216595006741	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
216595006743	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
216595006744	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
216595006745	Bacterial transcriptional regulator; Region: IclR; pfam01614
216595006748	PS01051 Bacterial regulatory proteins, iclR family signature.
216595006749	benzoate transport; Region: 2A0115; TIGR00895
216595006750	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595006751	putative substrate translocation pore; other site
216595006752	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595006753	12 probable transmembrane helices predicted for PFLU1362 by TMHMM2.0 at aa 54-76, 91-113, 120-142, 146-168, 175-197, 207-229, 292-314, 324-346, 358-380, 384-406, 419-441 and 446-468
216595006755	PS00216 Sugar transport proteins signature 1.
216595006756	PS00217 Sugar transport proteins signature 2.
216595006757	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
216595006759	Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057
216595006761	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
216595006762	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
216595006763	dimer interface [polypeptide binding]; other site
216595006764	active site
216595006766	PS00098 Thiolases acyl-enzyme intermediate signature.
216595006768	PS00737 Thiolases signature 2.
216595006769	PS00099 Thiolases active site.
216595006770	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
216595006771	Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464
216595006772	heterodimer interface [polypeptide binding]; other site
216595006773	multimer interface [polypeptide binding]; other site
216595006774	active site
216595006776	PS00083 Intradiol ring-cleavage dioxygenases signature.
216595006777	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
216595006778	heterodimer interface [polypeptide binding]; other site
216595006779	active site
216595006781	PS00083 Intradiol ring-cleavage dioxygenases signature.
216595006782	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
216595006783	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595006784	putative substrate translocation pore; other site
216595006786	12 probable transmembrane helices predicted for PFLU1368 by TMHMM2.0 at aa 21-43, 58-80, 93-112, 117-136, 156-178, 193-210, 241-263, 278-300, 307-324, 334-356, 369-391 and 401-418
216595006787	PS00217 Sugar transport proteins signature 2.
216595006788	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053
216595006789	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
216595006790	tetramer interface [polypeptide binding]; other site
216595006791	active site
216595006793	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595006794	PS00163 Fumarate lyases signature.
216595006795	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
216595006797	4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425
216595006799	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
216595006800	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
216595006801	NodB motif; other site
216595006802	active site
216595006803	catalytic site [active]
216595006804	metal binding site [ion binding]; metal-binding site
216595006806	1 probable transmembrane helix predicted for PFLU1372 by TMHMM2.0 at aa 26-45
216595006807	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595006808	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
216595006809	PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.
216595006813	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
216595006814	PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.
216595006818	outer membrane porin, OprD family; Region: OprD; pfam03573
216595006820	PS00309 Galaptin signature.
216595006821	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
216595006822	HSP70 interaction site [polypeptide binding]; other site
216595006824	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
216595006825	Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235
216595006826	nucleotide binding site [chemical binding]; other site
216595006827	putative NEF/HSP70 interaction site [polypeptide binding]; other site
216595006828	SBD interface [polypeptide binding]; other site
216595006830	PS01036 Heat shock hsp70 proteins family signature 3.
216595006831	PS00329 Heat shock hsp70 proteins family signature 2.
216595006832	PS00297 Heat shock hsp70 proteins family signature 1.
216595006833	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
216595006836	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595006837	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
216595006838	Protein export membrane protein; Region: SecD_SecF; cl14618
216595006840	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
216595006841	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
216595006842	HlyD family secretion protein; Region: HlyD_3; pfam13437
216595006844	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595006845	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
216595006846	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216595006847	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
216595006849	PS01081 Bacterial regulatory proteins, tetR family signature.
216595006851	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
216595006852	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
216595006853	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
216595006854	active site
216595006855	CoA binding site [chemical binding]; other site
216595006856	AMP binding site [chemical binding]; other site
216595006858	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
216595006860	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
216595006861	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
216595006862	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
216595006865	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
216595006866	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
216595006867	glutamine binding [chemical binding]; other site
216595006868	catalytic triad [active]
216595006870	PS00442 Glutamine amidotransferases class-I active site.
216595006871	PS00572 Glycosyl hydrolases family 1 active site.
216595006872	Autoinducer binding domain; Region: Autoind_bind; pfam03472
216595006873	LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541
216595006874	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216595006875	DNA binding residues [nucleotide binding]
216595006876	dimerization interface [polypeptide binding]; other site
216595006879	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
216595006880	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
216595006881	FMN binding site [chemical binding]; other site
216595006882	active site
216595006883	substrate binding site [chemical binding]; other site
216595006884	catalytic residue [active]
216595006886	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595006887	putative substrate translocation pore; other site
216595006888	Major Facilitator Superfamily; Region: MFS_1; pfam07690
216595006890	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
216595006891	dimerization interface [polypeptide binding]; other site
216595006892	putative DNA binding site [nucleotide binding]; other site
216595006893	putative Zn2+ binding site [ion binding]; other site
216595006895	Protein of unknown function, DUF479; Region: DUF479; cl01203
216595006897	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
216595006898	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
216595006899	putative acyl-acceptor binding pocket; other site
216595006901	1 probable transmembrane helix predicted for PFLU1391 by TMHMM2.0 at aa 12-31
216595006902	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
216595006903	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
216595006904	Beta-lactamase; Region: Beta-lactamase; pfam00144
216595006906	1 probable transmembrane helix predicted for PFLU1395 by TMHMM2.0 at aa 7-24
216595006907	PS00294 Prenyl group binding site (CAAX box).
216595006908	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595006909	YceI-like domain; Region: YceI; pfam04264
216595006911	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
216595006912	PLD-like domain; Region: PLDc_2; pfam13091
216595006913	putative active site [active]
216595006914	catalytic site [active]
216595006915	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
216595006916	PLD-like domain; Region: PLDc_2; pfam13091
216595006917	putative active site [active]
216595006918	catalytic site [active]
216595006921	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
216595006922	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
216595006923	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
216595006926	LemA family; Region: LemA; pfam04011
216595006928	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595006929	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
216595006930	Repair protein; Region: Repair_PSII; pfam04536
216595006931	2 probable transmembrane helices predicted for PFLU1401 by TMHMM2.0 at aa 10-32 and 180-202
216595006933	Repair protein; Region: Repair_PSII; cl01535
216595006935	2 probable transmembrane helices predicted for PFLU1402 by TMHMM2.0 at aa 72-94 and 98-120
216595006937	Methyltransferase domain; Region: Methyltransf_31; pfam13847
216595006938	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595006939	S-adenosylmethionine binding site [chemical binding]; other site
216595006940	EamA-like transporter family; Region: EamA; cl17759
216595006941	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
216595006942	EamA-like transporter family; Region: EamA; pfam00892
216595006945	Secretin and TonB N terminus short domain; Region: STN; smart00965
216595006946	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
216595006947	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216595006948	N-terminal plug; other site
216595006949	ligand-binding site [chemical binding]; other site
216595006953	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
216595006954	FecR protein; Region: FecR; pfam04773
216595006956	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
216595006957	RNA polymerase sigma factor; Reviewed; Region: PRK12527
216595006958	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
216595006959	DNA binding residues [nucleotide binding]
216595006962	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
216595006963	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
216595006964	inhibitor site; inhibition site
216595006965	active site
216595006966	dimer interface [polypeptide binding]; other site
216595006967	catalytic residue [active]
216595006969	class II aldolase/adducin domain protein; Provisional; Region: PRK07090
216595006970	intersubunit interface [polypeptide binding]; other site
216595006971	active site
216595006972	Zn2+ binding site [ion binding]; other site
216595006974	PS00070 Aldehyde dehydrogenases cysteine active site.
216595006975	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216595006976	non-specific DNA binding site [nucleotide binding]; other site
216595006977	salt bridge; other site
216595006978	sequence-specific DNA binding site [nucleotide binding]; other site
216595006979	Cupin domain; Region: Cupin_2; pfam07883
216595006982	putative alcohol dehydrogenase; Provisional; Region: PRK09860
216595006983	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
216595006984	dimer interface [polypeptide binding]; other site
216595006985	active site
216595006986	metal binding site [ion binding]; metal-binding site
216595006988	PS00913 Iron-containing alcohol dehydrogenases signature 1.
216595006989	PS00060 Iron-containing alcohol dehydrogenases signature 2.
216595006990	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595006991	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
216595006992	putative substrate translocation pore; other site
216595006994	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216595006995	NADH(P)-binding; Region: NAD_binding_10; pfam13460
216595006996	NAD(P) binding site [chemical binding]; other site
216595006997	active site
216595006998	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595006999	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595007000	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
216595007001	putative dimerization interface [polypeptide binding]; other site
216595007003	PS00044 Bacterial regulatory proteins, lysR family signature.
216595007005	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
216595007006	CoA-transferase family III; Region: CoA_transf_3; pfam02515
216595007008	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
216595007009	active site
216595007010	catalytic residues [active]
216595007011	metal binding site [ion binding]; metal-binding site
216595007013	PS00059 Zinc-containing alcohol dehydrogenases signature.
216595007014	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
216595007015	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595007016	putative substrate translocation pore; other site
216595007017	12 probable transmembrane helices predicted for PFLU1418 by TMHMM2.0 at aa 21-43, 67-89, 96-115, 125-147, 154-176, 189-211, 254-276, 286-308, 321-340, 345-367, 374-396 and 411-433
216595007019	Protein of unknown function, DUF606; Region: DUF606; pfam04657
216595007021	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595007022	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595007023	The C-terminal substrate binding domain of LysR-type transcriptional regulator ToxR regulates the expression of the toxoflavin biosynthesis genes; contains the type 2 periplasmic bindinig fold; Region: PBP2_ToxR; cd08465
216595007024	putative substrate binding pocket [chemical binding]; other site
216595007025	putative dimerization interface [polypeptide binding]; other site
216595007027	PS00044 Bacterial regulatory proteins, lysR family signature.
216595007029	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
216595007030	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
216595007031	active site
216595007032	metal binding site [ion binding]; metal-binding site
216595007034	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
216595007035	6 probable transmembrane helices predicted for PFLU1422 by TMHMM2.0 at aa 10-32, 39-61, 71-90, 111-133, 148-170 and 182-204
216595007037	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
216595007038	Low affinity iron permease; Region: Iron_permease; pfam04120
216595007040	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
216595007041	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
216595007042	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
216595007043	DNA binding site [nucleotide binding]
216595007044	active site
216595007047	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
216595007049	YcfA-like protein; Region: YcfA; pfam07927
216595007051	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
216595007052	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595007053	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
216595007054	dimerization interface [polypeptide binding]; other site
216595007055	substrate binding pocket [chemical binding]; other site
216595007058	PS00044 Bacterial regulatory proteins, lysR family signature.
216595007059	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595007060	putative substrate translocation pore; other site
216595007061	Major Facilitator Superfamily; Region: MFS_1; pfam07690
216595007062	12 probable transmembrane helices predicted for PFLU1430 by TMHMM2.0 at aa 36-58, 73-95, 102-121, 127-149, 162-181, 196-213, 233-255, 265-287, 299-316, 321-343, 356-378 and 383-405
216595007064	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595007065	Major Facilitator Superfamily; Region: MFS_1; pfam07690
216595007066	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595007068	9 probable transmembrane helices predicted for PFLU1431 by TMHMM2.0 at aa 35-57, 78-100, 171-193, 213-235, 250-272, 284-301, 306-328, 341-363 and 367-389
216595007069	Protein of unknown function (DUF3833); Region: DUF3833; pfam12915
216595007070	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595007071	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
216595007073	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
216595007074	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
216595007075	RNA binding surface [nucleotide binding]; other site
216595007076	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
216595007077	active site
216595007078	uracil binding [chemical binding]; other site
216595007080	PS01149 Rsu family of pseudouridine synthase signature.
216595007082	Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375
216595007083	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
216595007084	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
216595007085	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595007086	dimerization interface [polypeptide binding]; other site
216595007087	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595007088	dimer interface [polypeptide binding]; other site
216595007089	putative CheW interface [polypeptide binding]; other site
216595007092	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595007093	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
216595007094	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
216595007095	substrate binding site [chemical binding]; other site
216595007096	oxyanion hole (OAH) forming residues; other site
216595007097	trimer interface [polypeptide binding]; other site
216595007098	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
216595007100	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
216595007101	ligand binding site [chemical binding]; other site
216595007102	active site
216595007103	UGI interface [polypeptide binding]; other site
216595007104	catalytic site [active]
216595007106	PS00130 Uracil-DNA glycosylase signature.
216595007107	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343
216595007108	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
216595007109	Autotransporter beta-domain; Region: Autotransporter; pfam03797
216595007110	1 probable transmembrane helix predicted for PFLU1444 by TMHMM2.0 at aa 7-29
216595007113	Class II transport system: TTT
216595007114	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
216595007115	Putative ammonia monooxygenase; Region: AmoA; pfam05145
216595007116	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
216595007118	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
216595007120	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
216595007121	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
216595007123	outer membrane porin, OprD family; Region: OprD; pfam03573
216595007125	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
216595007126	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595007127	active site
216595007128	phosphorylation site [posttranslational modification]
216595007129	intermolecular recognition site; other site
216595007130	dimerization interface [polypeptide binding]; other site
216595007131	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216595007132	DNA binding site [nucleotide binding]
216595007135	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
216595007136	HAMP domain; Region: HAMP; pfam00672
216595007137	dimerization interface [polypeptide binding]; other site
216595007138	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595007139	dimer interface [polypeptide binding]; other site
216595007140	phosphorylation site [posttranslational modification]
216595007141	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595007142	ATP binding site [chemical binding]; other site
216595007143	Mg2+ binding site [ion binding]; other site
216595007144	G-X-G motif; other site
216595007145	2 probable transmembrane helices predicted for PFLU1452 by TMHMM2.0 at aa 10-32 and 172-194
216595007150	HDOD domain; Region: HDOD; pfam08668
216595007152	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
216595007153	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
216595007155	Uncharacterized conserved protein [Function unknown]; Region: COG2938
216595007157	1 probable transmembrane helix predicted for PFLU1456 by TMHMM2.0 at aa 10-32
216595007159	PFI-3
216595007160	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
216595007161	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
216595007162	active site
216595007163	DNA binding site [nucleotide binding]
216595007164	Int/Topo IB signature motif; other site
216595007166	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
216595007167	PS00430 TonB-dependent receptor proteins signature 1.
216595007168	L-aspartate oxidase; Provisional; Region: PRK09077
216595007169	L-aspartate oxidase; Provisional; Region: PRK06175
216595007170	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
216595007173	RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923
216595007174	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
216595007175	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
216595007176	DNA binding residues [nucleotide binding]
216595007178	PS01063 Sigma-70 factors ECF subfamily signature.
216595007180	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073
216595007181	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
216595007182	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
216595007185	anti-sigma E factor; Provisional; Region: rseB; PRK09455
216595007186	MucB/RseB family; Region: MucB_RseB; pfam03888
216595007188	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
216595007189	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
216595007190	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
216595007191	protein binding site [polypeptide binding]; other site
216595007192	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
216595007193	protein binding site [polypeptide binding]; other site
216595007197	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
216595007198	Peptidase family M48; Region: Peptidase_M48; cl12018
216595007200	PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.
216595007201	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
216595007202	CPxP  motif; other site
216595007204	PS01148 Uncharacterized protein family UPF0033 signature.
216595007205	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
216595007206	Domain of unknown function DUF20; Region: UPF0118; pfam01594
216595007208	7 probable transmembrane helices predicted for PFLU1474 by TMHMM2.0 at aa 20-52, 72-94, 156-178, 218-235, 245-267, 279-301 and 311-333
216595007209	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
216595007210	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
216595007211	catalytic triad [active]
216595007213	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
216595007214	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
216595007215	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869
216595007216	dihydrodipicolinate synthase; Region: dapA; TIGR00674
216595007217	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
216595007218	dimer interface [polypeptide binding]; other site
216595007219	active site
216595007220	catalytic residue [active]
216595007222	PS00665 Dihydrodipicolinate synthetase signature 1.
216595007223	PS00666 Dihydrodipicolinate synthetase signature 2.
216595007224	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
216595007225	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
216595007226	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595007227	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
216595007229	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
216595007230	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
216595007231	ATP binding site [chemical binding]; other site
216595007232	active site
216595007233	substrate binding site [chemical binding]; other site
216595007235	PS01057 SAICAR synthetase signature 1.
216595007236	PS01058 SAICAR synthetase signature 2.
216595007237	Colicin pore forming domain; Region: Colicin; pfam01024
216595007239	PS00017 ATP/GTP-binding site motif A (P-loop).
216595007240	1 probable transmembrane helix predicted for PFLU1482 by TMHMM2.0 at aa 390-412
216595007241	ribonucleoside transporter; Reviewed; Region: nepI; PRK10213
216595007242	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595007243	putative substrate translocation pore; other site
216595007245	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
216595007246	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595007247	dimerization interface [polypeptide binding]; other site
216595007248	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
216595007249	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595007250	dimer interface [polypeptide binding]; other site
216595007251	putative CheW interface [polypeptide binding]; other site
216595007252	2 probable transmembrane helices predicted for PFLU1485 by TMHMM2.0 at aa 15-37 and 192-211
216595007255	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595007256	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595007257	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
216595007258	putative dimerization interface [polypeptide binding]; other site
216595007260	PS00044 Bacterial regulatory proteins, lysR family signature.
216595007262	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
216595007263	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
216595007264	citrate-proton symporter; Provisional; Region: PRK15075
216595007265	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595007266	putative substrate translocation pore; other site
216595007268	PS00216 Sugar transport proteins signature 1.
216595007269	PS00217 Sugar transport proteins signature 2.
216595007270	PS00216 Sugar transport proteins signature 1.
216595007271	Transcriptional regulators [Transcription]; Region: GntR; COG1802
216595007272	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595007273	DNA-binding site [nucleotide binding]; DNA binding site
216595007274	FCD domain; Region: FCD; pfam07729
216595007277	short chain dehydrogenase; Provisional; Region: PRK12829
216595007278	classical (c) SDRs; Region: SDR_c; cd05233
216595007279	NAD(P) binding site [chemical binding]; other site
216595007280	active site
216595007282	PS00061 Short-chain dehydrogenases/reductases family signature.
216595007283	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
216595007285	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
216595007287	5 probable transmembrane helices predicted for PFLU1494 by TMHMM2.0 at aa 27-44, 67-89, 101-118, 169-188 and 195-217
216595007289	6 probable transmembrane helices predicted for PFLU1495 by TMHMM2.0 at aa 5-27, 34-56, 66-88, 95-117, 132-154 and 161-183
216595007290	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
216595007291	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595007292	putative substrate translocation pore; other site
216595007293	12 probable transmembrane helices predicted for PFLU1496 by TMHMM2.0 at aa 41-58, 73-95, 108-130, 136-158, 171-193, 203-222, 271-293, 303-325, 338-355, 360-382, 389-411 and 421-443
216595007295	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595007296	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595007297	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464
216595007298	putative substrate binding pocket [chemical binding]; other site
216595007299	putative dimerization interface [polypeptide binding]; other site
216595007302	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
216595007303	putative substrate binding pocket [chemical binding]; other site
216595007304	trimer interface [polypeptide binding]; other site
216595007306	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595007307	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
216595007308	putative Zn2+ binding site [ion binding]; other site
216595007309	putative DNA binding site [nucleotide binding]; other site
216595007310	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
216595007311	substrate binding pocket [chemical binding]; other site
216595007312	dimerization interface [polypeptide binding]; other site
216595007315	PS00044 Bacterial regulatory proteins, lysR family signature.
216595007316	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
216595007317	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595007318	putative substrate translocation pore; other site
216595007320	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
216595007321	Arabidopsis betaine aldehyde dehydrogenase 1 and 2, ALDH family 10A8 and 10A9-like; Region: ALDH_F10_BADH; cd07110
216595007322	NAD(P) binding site [chemical binding]; other site
216595007323	catalytic residues [active]
216595007324	catalytic residues [active]
216595007326	PS00070 Aldehyde dehydrogenases cysteine active site.
216595007327	hypothetical protein; Provisional; Region: PRK07524
216595007328	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
216595007329	PYR/PP interface [polypeptide binding]; other site
216595007330	dimer interface [polypeptide binding]; other site
216595007331	TPP binding site [chemical binding]; other site
216595007332	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
216595007333	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
216595007334	TPP-binding site [chemical binding]; other site
216595007338	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
216595007339	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595007340	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
216595007341	substrate binding pocket [chemical binding]; other site
216595007342	dimerization interface [polypeptide binding]; other site
216595007344	PS00044 Bacterial regulatory proteins, lysR family signature.
216595007346	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216595007347	NADH(P)-binding; Region: NAD_binding_10; pfam13460
216595007348	NAD(P) binding site [chemical binding]; other site
216595007349	active site
216595007351	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
216595007353	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595007354	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595007355	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
216595007356	putative effector binding pocket; other site
216595007357	dimerization interface [polypeptide binding]; other site
216595007360	1 probable transmembrane helix predicted for PFLU1508 by TMHMM2.0 at aa 7-29
216595007361	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
216595007362	Cupin domain; Region: Cupin_2; cl17218
216595007363	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595007365	PS00041 Bacterial regulatory proteins, araC family signature.
216595007367	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
216595007368	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
216595007370	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595007371	Major Facilitator Superfamily; Region: MFS_1; pfam07690
216595007372	putative substrate translocation pore; other site
216595007373	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595007374	13 probable transmembrane helices predicted for PFLU1511 by TMHMM2.0 at aa 20-42, 55-77, 87-105, 112-134, 171-193, 206-228, 241-258, 271-293, 313-332, 344-363, 368-390, 410-432 and 481-503
216595007376	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
216595007378	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595007379	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
216595007380	substrate binding pocket [chemical binding]; other site
216595007381	membrane-bound complex binding site; other site
216595007382	hinge residues; other site
216595007384	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
216595007385	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
216595007387	PS00181 Glutamine synthetase putative ATP-binding region signature.
216595007388	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595007389	S-adenosylmethionine binding site [chemical binding]; other site
216595007391	ribonuclease D; Region: rnd; TIGR01388
216595007392	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
216595007393	catalytic site [active]
216595007394	putative active site [active]
216595007395	putative substrate binding site [chemical binding]; other site
216595007396	HRDC domain; Region: HRDC; pfam00570
216595007399	YcgL domain; Region: YcgL; cl01189
216595007401	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
216595007402	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
216595007403	NAD binding site [chemical binding]; other site
216595007404	ligand binding site [chemical binding]; other site
216595007405	catalytic site [active]
216595007407	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
216595007408	putative FMN binding site [chemical binding]; other site
216595007410	hypothetical protein; Provisional; Region: PRK05170
216595007412	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
216595007413	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
216595007415	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
216595007416	active site
216595007418	PS00190 Cytochrome c family heme-binding site signature.
216595007419	Putative ParB-like nuclease; Region: ParBc_2; cl17538
216595007421	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
216595007422	PS00017 ATP/GTP-binding site motif A (P-loop).
216595007423	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
216595007424	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
216595007425	ligand binding site [chemical binding]; other site
216595007426	flexible hinge region; other site
216595007428	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
216595007429	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
216595007432	2 probable transmembrane helices predicted for PFLU1530 by TMHMM2.0 at aa 31-53 and 111-133
216595007433	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
216595007434	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
216595007435	putative active site [active]
216595007436	putative dimer interface [polypeptide binding]; other site
216595007438	Protein of unknown function (DUF2937); Region: DUF2937; pfam11157
216595007439	2 probable transmembrane helices predicted for PFLU1532 by TMHMM2.0 at aa 5-24 and 134-156
216595007440	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595007441	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595007442	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
216595007443	dimerization interface [polypeptide binding]; other site
216595007446	PS00044 Bacterial regulatory proteins, lysR family signature.
216595007447	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
216595007448	putative active site [active]
216595007450	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
216595007451	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
216595007453	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
216595007455	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
216595007456	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
216595007457	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595007458	Walker A motif; other site
216595007459	ATP binding site [chemical binding]; other site
216595007460	Walker B motif; other site
216595007461	arginine finger; other site
216595007463	PS00017 ATP/GTP-binding site motif A (P-loop).
216595007464	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
216595007465	1 probable transmembrane helix predicted for PFLU1539 by TMHMM2.0 at aa 7-29
216595007466	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
216595007467	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
216595007468	dimer interface [polypeptide binding]; other site
216595007469	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595007470	catalytic residue [active]
216595007472	PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site.
216595007473	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
216595007474	2 probable transmembrane helices predicted for PFLU1541 by TMHMM2.0 at aa 5-24 and 293-311
216595007476	aconitate hydratase; Validated; Region: PRK09277
216595007477	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
216595007478	substrate binding site [chemical binding]; other site
216595007479	ligand binding site [chemical binding]; other site
216595007480	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
216595007481	substrate binding site [chemical binding]; other site
216595007484	PS01244 Aconitase family signature 2.
216595007485	PS00450 Aconitase family signature 1.
216595007486	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595007487	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
216595007488	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
216595007489	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
216595007490	CPxP  motif; other site
216595007492	PS01148 Uncharacterized protein family UPF0033 signature.
216595007493	multidrug efflux protein; Reviewed; Region: PRK01766
216595007494	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
216595007495	cation binding site [ion binding]; other site
216595007498	erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257
216595007499	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
216595007500	ligand binding site [chemical binding]; other site
216595007501	NAD binding site [chemical binding]; other site
216595007502	catalytic site [active]
216595007503	homodimer interface [polypeptide binding]; other site
216595007506	PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3.
216595007507	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
216595007508	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
216595007509	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
216595007510	Walker A/P-loop; other site
216595007511	ATP binding site [chemical binding]; other site
216595007512	Q-loop/lid; other site
216595007513	ABC transporter signature motif; other site
216595007514	Walker B; other site
216595007515	D-loop; other site
216595007516	H-loop/switch region; other site
216595007517	6 probable transmembrane helices predicted for PFLU1548 by TMHMM2.0 at aa 21-43, 68-90, 146-163, 168-187, 250-272 and 287-309
216595007520	PS00017 ATP/GTP-binding site motif A (P-loop).
216595007521	PS00211 ABC transporters family signature.
216595007522	lytic murein transglycosylase; Provisional; Region: PRK11619
216595007523	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
216595007524	N-acetyl-D-glucosamine binding site [chemical binding]; other site
216595007525	catalytic residue [active]
216595007527	ABC transporter ATPase component; Reviewed; Region: PRK11147
216595007528	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
216595007529	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
216595007530	ABC transporter; Region: ABC_tran_2; pfam12848
216595007531	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
216595007533	PS00017 ATP/GTP-binding site motif A (P-loop).
216595007534	PS00211 ABC transporters family signature.
216595007536	PS00017 ATP/GTP-binding site motif A (P-loop).
216595007537	PS00211 ABC transporters family signature.
216595007538	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
216595007539	Ligand Binding Site [chemical binding]; other site
216595007541	1 probable transmembrane helix predicted for PFLU1552 by TMHMM2.0 at aa 4-23
216595007542	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
216595007543	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
216595007544	substrate binding site [chemical binding]; other site
216595007545	oxyanion hole (OAH) forming residues; other site
216595007546	trimer interface [polypeptide binding]; other site
216595007547	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
216595007548	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
216595007550	PS00166 Enoyl-CoA hydratase/isomerase signature.
216595007552	PS00067 3-hydroxyacyl-CoA dehydrogenase signature.
216595007554	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
216595007555	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
216595007556	dimer interface [polypeptide binding]; other site
216595007557	active site
216595007559	PS00098 Thiolases acyl-enzyme intermediate signature.
216595007560	PS00178 Aminoacyl-transfer RNA synthetases class-I signature.
216595007562	PS00737 Thiolases signature 2.
216595007563	PS00099 Thiolases active site.
216595007564	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
216595007565	PS00430 TonB-dependent receptor proteins signature 1.
216595007567	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
216595007568	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
216595007569	active site
216595007570	interdomain interaction site; other site
216595007571	putative metal-binding site [ion binding]; other site
216595007572	nucleotide binding site [chemical binding]; other site
216595007573	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
216595007574	domain I; other site
216595007575	DNA binding groove [nucleotide binding]
216595007576	phosphate binding site [ion binding]; other site
216595007577	domain II; other site
216595007578	domain III; other site
216595007579	nucleotide binding site [chemical binding]; other site
216595007580	catalytic site [active]
216595007581	domain IV; other site
216595007582	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
216595007583	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
216595007584	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
216595007585	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
216595007588	PS00396 Prokaryotic DNA topoisomerase I active site.
216595007593	Cell division inhibitor SulA; Region: SulA; cl01880
216595007594	LexA repressor; Validated; Region: PRK00215
216595007595	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
216595007596	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
216595007597	Catalytic site [active]
216595007600	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
216595007601	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216595007602	Protein of unknown function (DUF3179); Region: DUF3179; pfam11376
216595007604	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
216595007605	beta-hexosaminidase; Provisional; Region: PRK05337
216595007607	PS00775 Glycosyl hydrolases family 3 active site.
216595007608	SWIM zinc finger; Region: SWIM; pfam04434
216595007609	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
216595007610	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
216595007611	ATP binding site [chemical binding]; other site
216595007612	putative Mg++ binding site [ion binding]; other site
216595007613	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
216595007614	nucleotide binding region [chemical binding]; other site
216595007615	ATP-binding site [chemical binding]; other site
216595007617	PS00030 Eukaryotic putative RNA-binding region RNP-1 signature.
216595007620	Protein of unknown function (DUF2803); Region: DUF2803; pfam10972
216595007621	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
216595007622	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
216595007623	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
216595007624	ATP binding site [chemical binding]; other site
216595007625	putative Mg++ binding site [ion binding]; other site
216595007626	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
216595007627	nucleotide binding region [chemical binding]; other site
216595007628	ATP-binding site [chemical binding]; other site
216595007629	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
216595007631	PS00107 Protein kinases ATP-binding region signature.
216595007634	PS00017 ATP/GTP-binding site motif A (P-loop).
216595007636	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289
216595007637	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
216595007638	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
216595007640	PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site.
216595007642	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
216595007643	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
216595007644	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
216595007647	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595007649	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
216595007650	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
216595007651	active site
216595007652	catalytic site [active]
216595007654	PilZ domain; Region: PilZ; pfam07238
216595007656	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
216595007657	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
216595007658	FtsX-like permease family; Region: FtsX; pfam02687
216595007659	4 probable transmembrane helices predicted for PFLU1572 by TMHMM2.0 at aa 21-43, 274-296, 317-339 and 382-404
216595007661	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
216595007662	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
216595007663	Walker A/P-loop; other site
216595007664	ATP binding site [chemical binding]; other site
216595007665	Q-loop/lid; other site
216595007666	ABC transporter signature motif; other site
216595007667	Walker B; other site
216595007668	D-loop; other site
216595007669	H-loop/switch region; other site
216595007671	PS00017 ATP/GTP-binding site motif A (P-loop).
216595007672	PS00211 ABC transporters family signature.
216595007673	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
216595007674	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
216595007675	FtsX-like permease family; Region: FtsX; pfam02687
216595007676	4 probable transmembrane helices predicted for PFLU1574 by TMHMM2.0 at aa 21-43, 272-294, 315-337 and 375-397
216595007678	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
216595007679	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595007680	dimerization interface [polypeptide binding]; other site
216595007681	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595007682	dimer interface [polypeptide binding]; other site
216595007683	phosphorylation site [posttranslational modification]
216595007684	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595007685	ATP binding site [chemical binding]; other site
216595007686	Mg2+ binding site [ion binding]; other site
216595007687	G-X-G motif; other site
216595007691	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
216595007692	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595007693	active site
216595007694	phosphorylation site [posttranslational modification]
216595007695	intermolecular recognition site; other site
216595007696	dimerization interface [polypeptide binding]; other site
216595007697	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216595007698	DNA binding site [nucleotide binding]
216595007701	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
216595007703	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
216595007704	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
216595007705	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
216595007707	Domain of unknown function (DUF4404); Region: DUF4404; pfam14357
216595007708	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
216595007709	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595007710	ggaaccnnnnnnnnnnnnnnnnccacnna
216595007711	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595007712	Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853
216595007714	PilZ domain; Region: PilZ; pfam07238
216595007716	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
216595007717	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595007718	active site
216595007719	phosphorylation site [posttranslational modification]
216595007720	intermolecular recognition site; other site
216595007721	dimerization interface [polypeptide binding]; other site
216595007722	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
216595007723	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
216595007726	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
216595007727	anti sigma factor interaction site; other site
216595007728	regulatory phosphorylation site [posttranslational modification]; other site
216595007731	transaldolase-like protein; Provisional; Region: PTZ00411
216595007732	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
216595007733	active site
216595007734	dimer interface [polypeptide binding]; other site
216595007735	catalytic residue [active]
216595007737	PS00958 Transaldolase active site.
216595007738	PS01054 Transaldolase signature 1.
216595007739	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
216595007740	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
216595007741	FMN binding site [chemical binding]; other site
216595007742	active site
216595007743	catalytic residues [active]
216595007744	substrate binding site [chemical binding]; other site
216595007746	PS01136 Uncharacterized protein family UPF0034 signature.
216595007747	Prophage 2
216595007748	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
216595007749	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
216595007750	active site
216595007751	DNA binding site [nucleotide binding]
216595007752	Int/Topo IB signature motif; other site
216595007754	capsid protein; Provisional; Region: N; PHA02538
216595007756	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838
216595007758	terminase ATPase subunit; Provisional; Region: P; PHA02535
216595007759	Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056
216595007760	Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373
216595007763	portal vertex protein; Provisional; Region: Q; PHA02536
216595007764	Phage portal protein; Region: Phage_portal; pfam04860
216595007766	Uncharacterized ACR, COG2135; Region: DUF159; cl03646
216595007768	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
216595007769	synthetase active site [active]
216595007770	NTP binding site [chemical binding]; other site
216595007771	metal binding site [ion binding]; metal-binding site
216595007774	LPS O-antigen length regulator; Provisional; Region: PRK10381
216595007775	1 probable transmembrane helix predicted for PFLU1601 by TMHMM2.0 at aa 189-211
216595007777	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
216595007778	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595007779	putative substrate translocation pore; other site
216595007781	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
216595007782	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595007783	dimer interface [polypeptide binding]; other site
216595007784	phosphorylation site [posttranslational modification]
216595007785	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595007786	ATP binding site [chemical binding]; other site
216595007787	G-X-G motif; other site
216595007788	Response regulator receiver domain; Region: Response_reg; pfam00072
216595007789	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595007790	active site
216595007791	phosphorylation site [posttranslational modification]
216595007792	intermolecular recognition site; other site
216595007793	dimerization interface [polypeptide binding]; other site
216595007794	1 probable transmembrane helix predicted for PFLU1603 by TMHMM2.0 at aa 64-86
216595007798	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
216595007799	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595007800	active site
216595007801	phosphorylation site [posttranslational modification]
216595007802	intermolecular recognition site; other site
216595007803	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
216595007806	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595007807	dimer interface [polypeptide binding]; other site
216595007808	phosphorylation site [posttranslational modification]
216595007809	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595007810	ATP binding site [chemical binding]; other site
216595007811	Mg2+ binding site [ion binding]; other site
216595007812	G-X-G motif; other site
216595007813	Response regulator receiver domain; Region: Response_reg; pfam00072
216595007814	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595007815	active site
216595007816	phosphorylation site [posttranslational modification]
216595007817	intermolecular recognition site; other site
216595007818	dimerization interface [polypeptide binding]; other site
216595007819	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
216595007820	2 probable transmembrane helices predicted for PFLU1605 by TMHMM2.0 at aa 37-59 and 349-371
216595007821	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595007825	PS00070 Aldehyde dehydrogenases cysteine active site.
216595007827	transcriptional regulator RcsB; Provisional; Region: PRK10840
216595007828	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595007829	active site
216595007830	phosphorylation site [posttranslational modification]
216595007831	intermolecular recognition site; other site
216595007832	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216595007833	DNA binding residues [nucleotide binding]
216595007834	dimerization interface [polypeptide binding]; other site
216595007837	PS00622 Bacterial regulatory proteins, luxR family signature.
216595007838	Fimbrial protein; Region: Fimbrial; pfam00419
216595007840	Fimbrial protein; Region: Fimbrial; pfam00419
216595007842	Fimbrial protein; Region: Fimbrial; pfam00419
216595007843	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
216595007844	PapC N-terminal domain; Region: PapC_N; pfam13954
216595007845	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
216595007846	PapC C-terminal domain; Region: PapC_C; pfam13953
216595007848	PS01151 Fimbrial biogenesis outer membrane usher protein signature.
216595007849	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
216595007850	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
216595007851	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
216595007853	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
216595007855	malate:quinone oxidoreductase; Validated; Region: PRK05257
216595007856	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
216595007858	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
216595007859	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
216595007861	PS00017 ATP/GTP-binding site motif A (P-loop).
216595007862	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595007863	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595007864	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477
216595007865	putative effector binding pocket; other site
216595007866	putative dimerization interface [polypeptide binding]; other site
216595007868	PS00044 Bacterial regulatory proteins, lysR family signature.
216595007870	1 probable transmembrane helix predicted for PFLU1616 by TMHMM2.0 at aa 10-29
216595007871	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595007872	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
216595007873	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
216595007875	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
216595007876	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
216595007878	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
216595007880	1 probable transmembrane helix predicted for PFLU1620 by TMHMM2.0 at aa 13-35
216595007881	trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656
216595007882	NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242
216595007883	Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241
216595007884	Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055
216595007886	Anthrax toxin LF subunit; Region: Anthrax_toxA; pfam03497
216595007888	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595007889	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595007890	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477
216595007891	putative effector binding pocket; other site
216595007892	putative dimerization interface [polypeptide binding]; other site
216595007895	PS00044 Bacterial regulatory proteins, lysR family signature.
216595007896	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595007897	acetylornithine aminotransferase; Provisional; Region: PRK02627
216595007898	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
216595007899	inhibitor-cofactor binding pocket; inhibition site
216595007900	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595007901	catalytic residue [active]
216595007903	PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site.
216595007904	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
216595007905	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595007906	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
216595007907	dimerization interface [polypeptide binding]; other site
216595007910	PS00044 Bacterial regulatory proteins, lysR family signature.
216595007911	putative transporter; Provisional; Region: PRK11043
216595007912	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595007913	12 probable transmembrane helices predicted for PFLU1626 by TMHMM2.0 at aa 7-29, 39-61, 73-92, 97-119, 131-153, 157-179, 210-232, 242-260, 273-295, 300-322, 335-357 and 361-383
216595007915	xanthine permease; Region: pbuX; TIGR03173
216595007917	12 probable transmembrane helices predicted for PFLU1628 by TMHMM2.0 at aa 56-76, 81-103, 110-129, 134-156, 163-185, 195-217, 224-246, 266-288, 351-370, 375-397, 410-427 and 437-459
216595007918	PS00095 C-5 cytosine-specific DNA methylases C-terminal signature.
216595007919	PS01116 Xanthine/uracil permeases family signature.
216595007920	PS00012 Phosphopantetheine attachment site.
216595007921	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
216595007923	Autoinducer binding domain; Region: Autoind_bind; pfam03472
216595007924	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
216595007925	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216595007926	DNA binding residues [nucleotide binding]
216595007927	dimerization interface [polypeptide binding]; other site
216595007930	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
216595007932	PS00120 Lipases, serine active site.
216595007933	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
216595007934	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595007935	dimer interface [polypeptide binding]; other site
216595007936	conserved gate region; other site
216595007937	putative PBP binding loops; other site
216595007938	ABC-ATPase subunit interface; other site
216595007939	6 probable transmembrane helices predicted for PFLU1632 by TMHMM2.0 at aa 13-35, 102-124, 144-166, 181-198, 249-271 and 286-308
216595007940	PS00215 Mitochondrial energy transfer proteins signature.
216595007942	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595007943	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
216595007944	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595007945	dimer interface [polypeptide binding]; other site
216595007946	conserved gate region; other site
216595007947	putative PBP binding loops; other site
216595007948	ABC-ATPase subunit interface; other site
216595007949	6 probable transmembrane helices predicted for PFLU1633 by TMHMM2.0 at aa 25-47, 92-114, 127-145, 150-167, 214-236 and 251-273
216595007951	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
216595007952	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
216595007953	Walker A/P-loop; other site
216595007954	ATP binding site [chemical binding]; other site
216595007955	Q-loop/lid; other site
216595007956	ABC transporter signature motif; other site
216595007957	Walker B; other site
216595007958	D-loop; other site
216595007959	H-loop/switch region; other site
216595007960	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
216595007962	PS00017 ATP/GTP-binding site motif A (P-loop).
216595007963	PS00211 ABC transporters family signature.
216595007965	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
216595007966	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
216595007967	Walker A/P-loop; other site
216595007968	ATP binding site [chemical binding]; other site
216595007969	Q-loop/lid; other site
216595007970	ABC transporter signature motif; other site
216595007971	Walker B; other site
216595007972	D-loop; other site
216595007973	H-loop/switch region; other site
216595007974	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
216595007976	PS00017 ATP/GTP-binding site motif A (P-loop).
216595007977	PS00211 ABC transporters family signature.
216595007979	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
216595007980	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
216595007981	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595007983	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
216595007984	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216595007985	NAD(P) binding site [chemical binding]; other site
216595007986	active site
216595007988	PS00061 Short-chain dehydrogenases/reductases family signature.
216595007990	phosphoglycolate phosphatase; Provisional; Region: PRK13222
216595007991	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216595007992	motif II; other site
216595007994	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
216595007995	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595007996	S-adenosylmethionine binding site [chemical binding]; other site
216595007998	N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045
216595007999	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
216595008000	active site
216595008001	putative substrate binding pocket [chemical binding]; other site
216595008003	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
216595008004	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
216595008006	DNA gyrase subunit A; Validated; Region: PRK05560
216595008007	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
216595008008	CAP-like domain; other site
216595008009	active site
216595008010	primary dimer interface [polypeptide binding]; other site
216595008011	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
216595008012	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
216595008013	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
216595008014	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
216595008015	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
216595008016	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
216595008024	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
216595008025	homodimer interface [polypeptide binding]; other site
216595008026	substrate-cofactor binding pocket; other site
216595008027	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595008028	catalytic residue [active]
216595008030	Chorismate mutase type II; Region: CM_2; cl00693
216595008031	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
216595008032	Prephenate dehydratase; Region: PDT; pfam00800
216595008033	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
216595008034	putative L-Phe binding site [chemical binding]; other site
216595008037	PS00857 Prephenate dehydratase signature 1.
216595008039	PS00858 Prephenate dehydratase signature 2.
216595008040	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
216595008041	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216595008042	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595008043	homodimer interface [polypeptide binding]; other site
216595008044	catalytic residue [active]
216595008046	PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site.
216595008047	bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK14806
216595008048	prephenate dehydrogenase; Validated; Region: PRK08507
216595008049	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
216595008050	hinge; other site
216595008051	active site
216595008054	PS00104 EPSP synthase signature 1.
216595008055	PS00017 ATP/GTP-binding site motif A (P-loop).
216595008056	cytidylate kinase; Provisional; Region: cmk; PRK00023
216595008057	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
216595008058	CMP-binding site; other site
216595008059	The sites determining sugar specificity; other site
216595008061	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
216595008062	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
216595008063	RNA binding site [nucleotide binding]; other site
216595008064	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
216595008065	RNA binding site [nucleotide binding]; other site
216595008066	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
216595008067	RNA binding site [nucleotide binding]; other site
216595008068	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
216595008069	RNA binding site [nucleotide binding]; other site
216595008070	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
216595008071	RNA binding site [nucleotide binding]; other site
216595008072	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
216595008073	RNA binding site [nucleotide binding]; other site
216595008080	PFI-4
216595008081	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595008082	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
216595008083	IHF dimer interface [polypeptide binding]; other site
216595008084	IHF - DNA interface [nucleotide binding]; other site
216595008086	PS00045 Bacterial histone-like DNA-binding proteins signature.
216595008087	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
216595008088	2 probable transmembrane helices predicted for PFLU1652 by TMHMM2.0 at aa 7-25 and 45-67
216595008089	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
216595008090	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
216595008092	11 probable transmembrane helices predicted for PFLU1653 by TMHMM2.0 at aa 4-26, 46-68, 88-110, 119-141, 145-167, 188-207, 231-253, 273-295, 305-327, 336-355 and 359-381
216595008093	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
216595008094	active site
216595008095	11 probable transmembrane helices predicted for PFLU1656 by TMHMM2.0 at aa 21-40, 44-66, 78-100, 110-132, 139-158, 178-200, 207-229, 234-251, 256-278, 340-358 and 371-393
216595008096	UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130
216595008097	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
216595008098	NAD(P) binding site [chemical binding]; other site
216595008099	homodimer interface [polypeptide binding]; other site
216595008100	substrate binding site [chemical binding]; other site
216595008101	active site
216595008102	Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485
216595008105	capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261
216595008106	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
216595008107	putative NAD(P) binding site [chemical binding]; other site
216595008108	active site
216595008109	putative substrate binding site [chemical binding]; other site
216595008110	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
216595008112	PS00061 Short-chain dehydrogenases/reductases family signature.
216595008113	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
216595008114	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
216595008115	active site
216595008116	homodimer interface [polypeptide binding]; other site
216595008118	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
216595008119	putative glycosyl transferase; Provisional; Region: PRK10307
216595008122	1 probable transmembrane helix predicted for PFLU1661 by TMHMM2.0 at aa 7-29
216595008123	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
216595008124	iron-sulfur cluster [ion binding]; other site
216595008125	[2Fe-2S] cluster binding site [ion binding]; other site
216595008126	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
216595008127	alpha subunit interface [polypeptide binding]; other site
216595008128	active site
216595008129	substrate binding site [chemical binding]; other site
216595008130	Fe binding site [ion binding]; other site
216595008132	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
216595008133	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
216595008134	dimer interface [polypeptide binding]; other site
216595008135	active site
216595008136	CoA binding pocket [chemical binding]; other site
216595008139	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
216595008140	classical (c) SDRs; Region: SDR_c; cd05233
216595008141	NAD(P) binding site [chemical binding]; other site
216595008142	active site
216595008144	PS00061 Short-chain dehydrogenases/reductases family signature.
216595008145	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
216595008146	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
216595008147	putative trimer interface [polypeptide binding]; other site
216595008148	putative CoA binding site [chemical binding]; other site
216595008153	PS00101 Hexapeptide-repeat containing-transferases signature.
216595008155	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
216595008156	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
216595008157	dimer interface [polypeptide binding]; other site
216595008158	active site
216595008159	CoA binding pocket [chemical binding]; other site
216595008162	PS00017 ATP/GTP-binding site motif A (P-loop).
216595008163	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
216595008164	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
216595008165	inhibitor-cofactor binding pocket; inhibition site
216595008166	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595008167	catalytic residue [active]
216595008169	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
216595008170	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
216595008171	NAD(P) binding site [chemical binding]; other site
216595008172	homodimer interface [polypeptide binding]; other site
216595008173	substrate binding site [chemical binding]; other site
216595008174	active site
216595008175	4 probable transmembrane helices predicted for PFLU1668 by TMHMM2.0 at aa 30-47, 54-76, 89-111 and 124-141
216595008177	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
216595008178	1 probable transmembrane helix predicted for PFLU1669 by TMHMM2.0 at aa 11-33
216595008179	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
216595008180	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216595008181	PS01148 Uncharacterized protein family UPF0033 signature.
216595008183	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
216595008184	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595008185	DNA-binding site [nucleotide binding]; DNA binding site
216595008186	FCD domain; Region: FCD; pfam07729
216595008189	Domain of unknown function (DUF1989); Region: DUF1989; cl01474
216595008190	Protein of unknown function (DUF2897); Region: DUF2897; pfam11446
216595008191	1 probable transmembrane helix predicted for PFLU1673 by TMHMM2.0 at aa 15-37
216595008192	ethanolamine permease; Region: 2A0305; TIGR00908
216595008194	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
216595008195	10 probable transmembrane helices predicted for PFLU1676 by TMHMM2.0 at aa 6-28, 66-88, 134-156, 177-199, 252-274, 286-305, 375-397, 418-440, 487-509 and 530-552
216595008197	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
216595008198	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
216595008199	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
216595008200	Soluble P-type ATPase [General function prediction only]; Region: COG4087
216595008201	7 probable transmembrane helices predicted for PFLU1677 by TMHMM2.0 at aa 48-70, 74-96, 227-249, 259-281, 592-614, 624-646 and 659-681
216595008204	PS00154 E1-E2 ATPases phosphorylation site.
216595008205	PS01229 Hypothetical cof family signature 2.
216595008207	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
216595008209	1 probable transmembrane helix predicted for PFLU1678 by TMHMM2.0 at aa 13-35
216595008210	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
216595008211	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
216595008212	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
216595008213	Ligand Binding Site [chemical binding]; other site
216595008214	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595008215	dimer interface [polypeptide binding]; other site
216595008216	phosphorylation site [posttranslational modification]
216595008217	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595008218	ATP binding site [chemical binding]; other site
216595008219	Mg2+ binding site [ion binding]; other site
216595008220	G-X-G motif; other site
216595008222	PS00017 ATP/GTP-binding site motif A (P-loop).
216595008224	4 probable transmembrane helices predicted for PFLU1679 by TMHMM2.0 at aa 385-407, 414-433, 437-459 and 466-484
216595008227	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
216595008228	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595008229	active site
216595008230	phosphorylation site [posttranslational modification]
216595008231	intermolecular recognition site; other site
216595008232	dimerization interface [polypeptide binding]; other site
216595008233	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216595008234	DNA binding site [nucleotide binding]
216595008237	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
216595008238	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
216595008239	active site
216595008240	nucleophile elbow; other site
216595008242	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595008243	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
216595008245	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
216595008246	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
216595008247	active site
216595008248	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
216595008249	active site 2 [active]
216595008250	active site 1 [active]
216595008251	Protein of unknown function (DUF962); Region: DUF962; cl01879
216595008252	Terminase small subunit; Region: Terminase_2; cl01513
216595008253	low GC region (40.21%)
216595008254	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
216595008255	RHS Repeat; Region: RHS_repeat; pfam05593
216595008256	RHS Repeat; Region: RHS_repeat; cl11982
216595008257	RHS Repeat; Region: RHS_repeat; cl11982
216595008258	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
216595008259	RHS Repeat; Region: RHS_repeat; pfam05593
216595008260	RHS Repeat; Region: RHS_repeat; pfam05593
216595008261	RHS Repeat; Region: RHS_repeat; pfam05593
216595008262	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
216595008263	RHS protein; Region: RHS; pfam03527
216595008264	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
216595008278	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595008279	dimerization interface [polypeptide binding]; other site
216595008280	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
216595008281	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595008282	dimer interface [polypeptide binding]; other site
216595008283	putative CheW interface [polypeptide binding]; other site
216595008286	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
216595008287	active site
216595008289	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
216595008290	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595008291	substrate binding pocket [chemical binding]; other site
216595008292	membrane-bound complex binding site; other site
216595008293	hinge residues; other site
216595008294	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
216595008295	N-acetyl-D-glucosamine binding site [chemical binding]; other site
216595008296	catalytic residue [active]
216595008298	DoxX; Region: DoxX; pfam07681
216595008299	4 probable transmembrane helices predicted for PFLU1690 by TMHMM2.0 at aa 13-32, 47-69, 76-98 and 108-130
216595008301	ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility and secretion]; Region: GldG; COG3225
216595008302	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
216595008303	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
216595008304	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216595008305	Walker A/P-loop; other site
216595008306	ATP binding site [chemical binding]; other site
216595008307	Q-loop/lid; other site
216595008308	ABC transporter signature motif; other site
216595008309	Walker B; other site
216595008310	D-loop; other site
216595008311	H-loop/switch region; other site
216595008313	JNK_SAPK-associated protein-1; Region: Jnk-SapK_ap_N; pfam09744
216595008314	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
216595008315	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
216595008316	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
216595008319	PS00830 Prokaryotic transcription elongation factors signature 2.
216595008320	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
216595008322	PS00778 Histidine acid phosphatases active site signature.
216595008324	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
216595008325	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
216595008326	Walker A/P-loop; other site
216595008327	ATP binding site [chemical binding]; other site
216595008328	Q-loop/lid; other site
216595008329	ABC transporter signature motif; other site
216595008330	Walker B; other site
216595008331	D-loop; other site
216595008332	H-loop/switch region; other site
216595008334	PS00211 ABC transporters family signature.
216595008335	PS00017 ATP/GTP-binding site motif A (P-loop).
216595008336	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
216595008337	active site
216595008338	catalytic triad [active]
216595008339	oxyanion hole [active]
216595008340	switch loop; other site
216595008342	PS01098 Lipolytic enzymes G-D-S-L family, serine active site.
216595008343	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
216595008344	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
216595008346	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595008347	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216595008348	Coenzyme A binding pocket [chemical binding]; other site
216595008349	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
216595008350	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
216595008352	PilZ domain; Region: PilZ; pfam07238
216595008353	2-dehydropantoate 2-reductase; Provisional; Region: PRK06249
216595008354	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
216595008355	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
216595008357	1 probable transmembrane helix predicted for PFLU1707 by TMHMM2.0 at aa 13-32
216595008359	5'-nucleotidase; Region: 5-nucleotidase; pfam06189
216595008361	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
216595008362	Ligand Binding Site [chemical binding]; other site
216595008364	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
216595008365	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595008366	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
216595008367	substrate binding site [chemical binding]; other site
216595008368	dimerization interface [polypeptide binding]; other site
216595008370	PS00044 Bacterial regulatory proteins, lysR family signature.
216595008372	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
216595008373	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
216595008374	1 probable transmembrane helix predicted for PFLU1712 by TMHMM2.0 at aa 42-64
216595008375	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394
216595008376	Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093
216595008377	elongation factor P; Validated; Region: PRK00529
216595008378	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
216595008379	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
216595008380	RNA binding site [nucleotide binding]; other site
216595008381	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
216595008382	RNA binding site [nucleotide binding]; other site
216595008386	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
216595008387	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
216595008389	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
216595008391	Transcriptional regulators [Transcription]; Region: MarR; COG1846
216595008392	MarR family; Region: MarR; pfam01047
216595008394	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595008395	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595008396	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
216595008397	putative effector binding pocket; other site
216595008398	dimerization interface [polypeptide binding]; other site
216595008401	PS00044 Bacterial regulatory proteins, lysR family signature.
216595008402	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
216595008404	8 probable transmembrane helices predicted for PFLU1719 by TMHMM2.0 at aa 7-29, 44-61, 74-93, 97-116, 136-158, 173-195, 202-219 and 229-247
216595008405	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595008406	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595008407	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
216595008408	dimerization interface [polypeptide binding]; other site
216595008411	Domain of unknown function (DUF1127); Region: DUF1127; pfam06568
216595008413	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
216595008414	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
216595008416	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
216595008418	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595008419	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595008420	enoyl-CoA hydratase; Provisional; Region: PRK06563
216595008421	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
216595008422	substrate binding site [chemical binding]; other site
216595008423	oxyanion hole (OAH) forming residues; other site
216595008424	trimer interface [polypeptide binding]; other site
216595008426	helicase 45; Provisional; Region: PTZ00424
216595008427	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
216595008428	ATP binding site [chemical binding]; other site
216595008429	Mg++ binding site [ion binding]; other site
216595008430	motif III; other site
216595008431	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
216595008432	nucleotide binding region [chemical binding]; other site
216595008433	ATP-binding site [chemical binding]; other site
216595008434	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
216595008436	PS00017 ATP/GTP-binding site motif A (P-loop).
216595008437	PS00039 DEAD-box subfamily ATP-dependent helicases signature.
216595008440	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
216595008441	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
216595008442	putative active site [active]
216595008443	metal binding site [ion binding]; metal-binding site
216595008445	thiopurine S-methyltransferase; Reviewed; Region: PRK13255
216595008448	heat shock protein HtpX; Provisional; Region: PRK05457
216595008451	aminotransferase AlaT; Validated; Region: PRK09265
216595008452	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216595008453	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595008454	homodimer interface [polypeptide binding]; other site
216595008455	catalytic residue [active]
216595008457	methionine sulfoxide reductase B; Provisional; Region: PRK00222
216595008458	SelR domain; Region: SelR; pfam01641
216595008460	Transposase; Region: DEDD_Tnp_IS110; pfam01548
216595008461	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
216595008462	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
216595008465	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
216595008466	catalytic residues [active]
216595008467	dimer interface [polypeptide binding]; other site
216595008469	PS00460 Glutathione peroxidases selenocysteine active site.
216595008470	PS00763 Glutathione peroxidases signature 2.
216595008471	Transcriptional regulators [Transcription]; Region: MarR; COG1846
216595008472	MarR family; Region: MarR; pfam01047
216595008474	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595008475	dimer interface [polypeptide binding]; other site
216595008476	phosphorylation site [posttranslational modification]
216595008477	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595008478	ATP binding site [chemical binding]; other site
216595008479	Mg2+ binding site [ion binding]; other site
216595008480	G-X-G motif; other site
216595008481	Response regulator receiver domain; Region: Response_reg; pfam00072
216595008482	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595008483	active site
216595008484	phosphorylation site [posttranslational modification]
216595008485	intermolecular recognition site; other site
216595008486	dimerization interface [polypeptide binding]; other site
216595008490	1 probable transmembrane helix predicted for PFLU1736 by TMHMM2.0 at aa 203-225
216595008491	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
216595008492	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595008493	Walker A motif; other site
216595008494	ATP binding site [chemical binding]; other site
216595008495	Walker B motif; other site
216595008496	PS00017 ATP/GTP-binding site motif A (P-loop).
216595008498	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
216595008499	GAF domain; Region: GAF_2; pfam13185
216595008501	PS01320 Uncharacterized protein family UPF0067 signature.
216595008502	hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959
216595008503	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595008504	substrate binding pocket [chemical binding]; other site
216595008505	membrane-bound complex binding site; other site
216595008506	hinge residues; other site
216595008507	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595008508	substrate binding pocket [chemical binding]; other site
216595008509	membrane-bound complex binding site; other site
216595008510	hinge residues; other site
216595008511	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595008512	putative active site [active]
216595008513	heme pocket [chemical binding]; other site
216595008514	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595008515	dimer interface [polypeptide binding]; other site
216595008516	phosphorylation site [posttranslational modification]
216595008517	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595008518	ATP binding site [chemical binding]; other site
216595008519	Mg2+ binding site [ion binding]; other site
216595008520	G-X-G motif; other site
216595008521	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595008522	active site
216595008523	phosphorylation site [posttranslational modification]
216595008524	intermolecular recognition site; other site
216595008525	dimerization interface [polypeptide binding]; other site
216595008526	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
216595008527	putative binding surface; other site
216595008528	active site
216595008534	1 probable transmembrane helix predicted for PFLU1739 by TMHMM2.0 at aa 545-567
216595008536	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
216595008537	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595008538	active site
216595008539	phosphorylation site [posttranslational modification]
216595008540	intermolecular recognition site; other site
216595008541	dimerization interface [polypeptide binding]; other site
216595008542	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216595008543	DNA binding residues [nucleotide binding]
216595008544	dimerization interface [polypeptide binding]; other site
216595008546	PS00622 Bacterial regulatory proteins, luxR family signature.
216595008548	Response regulator receiver domain; Region: Response_reg; pfam00072
216595008549	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595008550	active site
216595008551	phosphorylation site [posttranslational modification]
216595008552	intermolecular recognition site; other site
216595008553	dimerization interface [polypeptide binding]; other site
216595008555	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
216595008556	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
216595008557	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
216595008559	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
216595008560	EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388
216595008562	Predicted membrane protein [Function unknown]; Region: COG5393
216595008563	Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575
216595008565	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
216595008567	11 probable transmembrane helices predicted for PFLU1747 by TMHMM2.0 at aa 31-50, 63-85, 105-127, 134-156, 176-198, 210-232, 247-269, 274-293, 297-314, 326-348 and 363-385
216595008568	PS01219 Ammonium transporters signature.
216595008569	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
216595008570	putative cation:proton antiport protein; Provisional; Region: PRK10669
216595008571	TrkA-N domain; Region: TrkA_N; pfam02254
216595008574	PS00041 Bacterial regulatory proteins, araC family signature.
216595008575	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
216595008577	PS00017 ATP/GTP-binding site motif A (P-loop).
216595008578	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
216595008579	Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558
216595008580	probable active site [active]
216595008582	PS01129 Rlu family of pseudouridine synthase signature.
216595008583	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
216595008585	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595008586	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
216595008587	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
216595008588	GTP binding site; other site
216595008589	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
216595008590	MPT binding site; other site
216595008591	trimer interface [polypeptide binding]; other site
216595008593	PS01078 Molybdenum cofactor biosynthesis proteins signature 1.
216595008594	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
216595008595	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
216595008596	dimer interface [polypeptide binding]; other site
216595008597	putative functional site; other site
216595008598	putative MPT binding site; other site
216595008601	PS01079 Molybdenum cofactor biosynthesis proteins signature 2.
216595008603	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
216595008605	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
216595008606	PS00017 ATP/GTP-binding site motif A (P-loop).
216595008607	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
216595008608	Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231
216595008609	Walker A/P-loop; other site
216595008610	ATP binding site [chemical binding]; other site
216595008611	Q-loop/lid; other site
216595008612	ABC transporter signature motif; other site
216595008613	Walker B; other site
216595008614	D-loop; other site
216595008615	H-loop/switch region; other site
216595008617	PS00017 ATP/GTP-binding site motif A (P-loop).
216595008618	PS00211 ABC transporters family signature.
216595008619	heme exporter protein CcmB; Region: ccmB; TIGR01190
216595008621	6 probable transmembrane helices predicted for PFLU1759 by TMHMM2.0 at aa 23-45, 52-74, 101-123, 130-152, 162-184 and 197-219
216595008622	heme exporter protein CcmC; Region: ccmC; TIGR01191
216595008624	6 probable transmembrane helices predicted for PFLU1760 by TMHMM2.0 at aa 34-56, 71-93, 105-127, 142-164, 171-193 and 213-235
216595008625	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595008626	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
216595008628	1 probable transmembrane helix predicted for PFLU1761 by TMHMM2.0 at aa 18-40
216595008629	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
216595008631	1 probable transmembrane helix predicted for PFLU1762 by TMHMM2.0 at aa 9-31
216595008632	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
216595008633	15 probable transmembrane helices predicted for PFLU1763 by TMHMM2.0 at aa 15-34, 46-68, 96-118, 125-147, 181-203, 216-238, 253-270, 282-304, 319-337, 358-380, 395-417, 426-448, 452-471, 492-514 and 620-639
216595008635	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
216595008636	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
216595008637	catalytic residues [active]
216595008638	central insert; other site
216595008639	1 probable transmembrane helix predicted for PFLU1764 by TMHMM2.0 at aa 7-26
216595008641	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
216595008643	2 probable transmembrane helices predicted for PFLU1765 by TMHMM2.0 at aa 5-22 and 103-125
216595008644	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
216595008645	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
216595008646	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
216595008647	binding surface
216595008648	TPR motif; other site
216595008649	2 probable transmembrane helices predicted for PFLU1766 by TMHMM2.0 at aa 4-26 and 94-116
216595008652	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595008653	Major Facilitator Superfamily; Region: MFS_1; pfam07690
216595008654	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595008655	putative substrate translocation pore; other site
216595008656	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595008658	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
216595008659	prephenate dehydrogenase; Validated; Region: PRK08507
216595008661	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
216595008662	Glutamine amidotransferase class-I; Region: GATase; pfam00117
216595008663	glutamine binding [chemical binding]; other site
216595008664	catalytic triad [active]
216595008665	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
216595008666	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
216595008667	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
216595008671	PS00442 Glutamine amidotransferases class-I active site.
216595008672	Chorismate mutase type II; Region: CM_2; smart00830
216595008674	hypothetical protein; Provisional; Region: PRK07505
216595008675	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
216595008676	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
216595008677	catalytic residue [active]
216595008679	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
216595008680	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595008681	S-adenosylmethionine binding site [chemical binding]; other site
216595008683	PS00092 N-6 Adenine-specific DNA methylases signature.
216595008684	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
216595008687	PS00175 Phosphoglycerate mutase family phosphohistidine signature.
216595008688	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
216595008689	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
216595008690	Walker A/P-loop; other site
216595008691	ATP binding site [chemical binding]; other site
216595008692	Q-loop/lid; other site
216595008693	ABC transporter signature motif; other site
216595008694	Walker B; other site
216595008695	D-loop; other site
216595008696	H-loop/switch region; other site
216595008698	PS00017 ATP/GTP-binding site motif A (P-loop).
216595008699	PS00211 ABC transporters family signature.
216595008700	phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431
216595008701	ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639
216595008702	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595008703	dimer interface [polypeptide binding]; other site
216595008704	conserved gate region; other site
216595008705	ABC-ATPase subunit interface; other site
216595008706	6 probable transmembrane helices predicted for PFLU1779 by TMHMM2.0 at aa 13-32, 71-93, 122-144, 180-197, 204-226 and 230-252
216595008708	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
216595008709	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595008710	DNA-binding site [nucleotide binding]; DNA binding site
216595008711	UTRA domain; Region: UTRA; pfam07702
216595008713	PS00043 Bacterial regulatory proteins, gntR family signature.
216595008715	Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754
216595008717	carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147
216595008719	Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861
216595008721	Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007
216595008723	phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701
216595008724	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
216595008725	Walker A/P-loop; other site
216595008726	ATP binding site [chemical binding]; other site
216595008727	Q-loop/lid; other site
216595008728	ABC transporter signature motif; other site
216595008729	Walker B; other site
216595008730	D-loop; other site
216595008731	H-loop/switch region; other site
216595008732	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
216595008734	PS00017 ATP/GTP-binding site motif A (P-loop).
216595008735	PS00211 ABC transporters family signature.
216595008737	ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778
216595008738	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216595008739	Walker A/P-loop; other site
216595008740	ATP binding site [chemical binding]; other site
216595008741	Q-loop/lid; other site
216595008742	ABC transporter signature motif; other site
216595008743	Walker B; other site
216595008744	D-loop; other site
216595008745	H-loop/switch region; other site
216595008747	PS00017 ATP/GTP-binding site motif A (P-loop).
216595008748	PS00211 ABC transporters family signature.
216595008749	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
216595008750	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
216595008751	PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306
216595008752	active site
216595008754	PS00190 Cytochrome c family heme-binding site signature.
216595008755	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
216595008756	AAA domain; Region: AAA_18; pfam13238
216595008757	active site
216595008758	carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244
216595008759	putative hydrolase; Provisional; Region: PRK02113
216595008761	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595008762	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595008763	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
216595008764	putative effector binding pocket; other site
216595008765	dimerization interface [polypeptide binding]; other site
216595008768	YcfA-like protein; Region: YcfA; pfam07927
216595008770	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
216595008772	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
216595008773	active site
216595008774	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
216595008776	PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.
216595008780	1 probable transmembrane helix predicted for PFLU1793 by TMHMM2.0 at aa 475-497
216595008781	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
216595008782	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595008783	putative substrate translocation pore; other site
216595008785	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
216595008786	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
216595008788	Ion transport protein; Region: Ion_trans; pfam00520
216595008789	Ion channel; Region: Ion_trans_2; pfam07885
216595008790	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
216595008792	Urea transporter; Region: UT; pfam03253
216595008794	pyruvate kinase; Provisional; Region: PRK06247
216595008795	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
216595008796	domain interfaces; other site
216595008797	active site
216595008800	PS00110 Pyruvate kinase active site signature.
216595008801	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
216595008802	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
216595008803	MOFRL family; Region: MOFRL; pfam05161
216595008805	tartronate semialdehyde reductase; Provisional; Region: PRK15059
216595008806	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
216595008808	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
216595008810	glyoxylate carboligase; Provisional; Region: PRK11269
216595008811	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
216595008812	PYR/PP interface [polypeptide binding]; other site
216595008813	dimer interface [polypeptide binding]; other site
216595008814	TPP binding site [chemical binding]; other site
216595008815	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
216595008816	Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006
216595008817	TPP-binding site [chemical binding]; other site
216595008821	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
216595008823	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
216595008824	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216595008825	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
216595008828	Protein of unknown function (DUF808); Region: DUF808; pfam05661
216595008830	4 probable transmembrane helices predicted for PFLU1806 by TMHMM2.0 at aa 91-113, 195-217, 252-274 and 294-316
216595008831	VacJ like lipoprotein; Region: VacJ; cl01073
216595008833	3 probable transmembrane helices predicted for PFLU1810 by TMHMM2.0 at aa 7-29, 61-83 and 90-112
216595008834	Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309
216595008836	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
216595008837	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
216595008839	Predicted membrane protein [Function unknown]; Region: COG3162
216595008841	2 probable transmembrane helices predicted for PFLU1813 by TMHMM2.0 at aa 24-46 and 61-83
216595008842	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
216595008843	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
216595008844	Na binding site [ion binding]; other site
216595008845	14 probable transmembrane helices predicted for PFLU1814 by TMHMM2.0 at aa 5-24, 34-56, 77-99, 105-127, 148-170, 185-204, 211-228, 266-288, 301-323, 364-386, 407-426, 431-453, 465-487 and 497-519
216595008847	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
216595008848	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
216595008849	dimer interface [polypeptide binding]; other site
216595008850	active site
216595008851	citrylCoA binding site [chemical binding]; other site
216595008852	NADH binding [chemical binding]; other site
216595008853	cationic pore residues; other site
216595008854	oxalacetate/citrate binding site [chemical binding]; other site
216595008855	coenzyme A binding site [chemical binding]; other site
216595008856	catalytic triad [active]
216595008858	PS00480 Citrate synthase signature.
216595008859	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
216595008860	Iron-sulfur protein interface; other site
216595008861	proximal quinone binding site [chemical binding]; other site
216595008862	SdhD (CybS) interface [polypeptide binding]; other site
216595008863	proximal heme binding site [chemical binding]; other site
216595008865	PS01000 Succinate dehydrogenase cytochrome b subunit signature 1.
216595008866	3 probable transmembrane helices predicted for PFLU1816 by TMHMM2.0 at aa 21-43, 68-90 and 103-123
216595008867	PS01001 Succinate dehydrogenase cytochrome b subunit signature 2.
216595008868	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
216595008869	SdhC subunit interface [polypeptide binding]; other site
216595008870	proximal heme binding site [chemical binding]; other site
216595008871	cardiolipin binding site; other site
216595008872	Iron-sulfur protein interface; other site
216595008873	proximal quinone binding site [chemical binding]; other site
216595008874	3 probable transmembrane helices predicted for PFLU1817 by TMHMM2.0 at aa 25-47, 57-79 and 100-122
216595008875	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05675
216595008876	L-aspartate oxidase; Provisional; Region: PRK06175
216595008877	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
216595008879	PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site.
216595008881	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
216595008882	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
216595008883	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
216595008884	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
216595008885	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
216595008886	TPP-binding site [chemical binding]; other site
216595008887	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
216595008890	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
216595008891	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
216595008892	E3 interaction surface; other site
216595008893	lipoyl attachment site [posttranslational modification]; other site
216595008894	e3 binding domain; Region: E3_binding; pfam02817
216595008895	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
216595008897	PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site.
216595008900	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
216595008901	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
216595008902	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
216595008903	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
216595008905	PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site.
216595008908	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
216595008909	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
216595008910	CoA-ligase; Region: Ligase_CoA; pfam00549
216595008913	PS01217 ATP-citrate lyase / succinyl-CoA ligases family signature 3.
216595008914	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
216595008915	CoA binding domain; Region: CoA_binding; pfam02629
216595008916	CoA-ligase; Region: Ligase_CoA; pfam00549
216595008919	PS01216 ATP-citrate lyase / succinyl-CoA ligases family signature 1.
216595008920	PS00399 ATP-citrate lyase / succinyl-CoA ligases family active site.
216595008922	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
216595008924	12 probable transmembrane helices predicted for PFLU1825 by TMHMM2.0 at aa 82-104, 114-136, 149-171, 191-213, 220-242, 262-284, 297-319, 348-370, 377-399, 409-431, 444-466 and 481-498
216595008925	Predicted membrane protein [Function unknown]; Region: COG3821
216595008926	4 probable transmembrane helices predicted for PFLU1826 by TMHMM2.0 at aa 29-51, 93-115, 136-158 and 215-237
216595008928	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595008929	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
216595008930	CoenzymeA binding site [chemical binding]; other site
216595008931	subunit interaction site [polypeptide binding]; other site
216595008932	PHB binding site; other site
216595008934	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
216595008935	CoenzymeA binding site [chemical binding]; other site
216595008936	subunit interaction site [polypeptide binding]; other site
216595008937	PHB binding site; other site
216595008939	heat shock protein 90; Provisional; Region: PRK05218
216595008940	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595008941	ATP binding site [chemical binding]; other site
216595008942	Mg2+ binding site [ion binding]; other site
216595008943	G-X-G motif; other site
216595008944	PS00298 Heat shock hsp90 proteins family signature.
216595008947	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
216595008948	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
216595008950	Pirin-related protein [General function prediction only]; Region: COG1741
216595008951	Pirin; Region: Pirin; pfam02678
216595008952	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
216595008955	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
216595008957	Amidohydrolase; Region: Amidohydro_2; pfam04909
216595008959	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
216595008960	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
216595008961	dimer interface [polypeptide binding]; other site
216595008962	active site
216595008964	PS00639 Eukaryotic thiol (cysteine) proteases histidine active site.
216595008966	PS00606 Beta-ketoacyl synthases active site.
216595008967	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595008968	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
216595008969	active site 1 [active]
216595008970	dimer interface [polypeptide binding]; other site
216595008971	active site 2 [active]
216595008973	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595008974	dimerization interface [polypeptide binding]; other site
216595008975	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595008976	dimer interface [polypeptide binding]; other site
216595008977	phosphorylation site [posttranslational modification]
216595008978	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595008979	ATP binding site [chemical binding]; other site
216595008980	Mg2+ binding site [ion binding]; other site
216595008981	G-X-G motif; other site
216595008982	Response regulator receiver domain; Region: Response_reg; pfam00072
216595008983	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595008984	active site
216595008985	phosphorylation site [posttranslational modification]
216595008986	intermolecular recognition site; other site
216595008987	dimerization interface [polypeptide binding]; other site
216595008992	ABC transporter substrate binding protein; Region: ABC_sub_bind; cl17301
216595008993	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
216595008994	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
216595008997	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
216595008998	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
216595008999	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
216595009002	Domain of unknown function (DUF4389); Region: DUF4389; pfam14333
216595009003	1 probable transmembrane helix predicted for PFLU1841 by TMHMM2.0 at aa 25-47
216595009004	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
216595009005	catalytic core [active]
216595009007	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
216595009008	Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; Region: LC_FACS_bac; cd05932
216595009009	acyl-activating enzyme (AAE) consensus motif; other site
216595009010	putative AMP binding site [chemical binding]; other site
216595009011	putative active site [active]
216595009012	putative CoA binding site [chemical binding]; other site
216595009014	PS00455 Putative AMP-binding domain signature.
216595009015	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
216595009016	CoenzymeA binding site [chemical binding]; other site
216595009017	subunit interaction site [polypeptide binding]; other site
216595009018	PHB binding site; other site
216595009020	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
216595009022	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
216595009024	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
216595009025	Domain of unknown function DUF20; Region: UPF0118; pfam01594
216595009026	8 probable transmembrane helices predicted for PFLU1848 by TMHMM2.0 at aa 7-26, 31-53, 58-80, 149-171, 208-230, 235-257, 269-286 and 301-323
216595009028	HAMP domain; Region: HAMP; pfam00672
216595009029	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595009030	dimer interface [polypeptide binding]; other site
216595009031	phosphorylation site [posttranslational modification]
216595009032	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595009033	ATP binding site [chemical binding]; other site
216595009034	Mg2+ binding site [ion binding]; other site
216595009035	G-X-G motif; other site
216595009039	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
216595009040	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595009041	active site
216595009042	phosphorylation site [posttranslational modification]
216595009043	intermolecular recognition site; other site
216595009044	dimerization interface [polypeptide binding]; other site
216595009045	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216595009046	DNA binding site [nucleotide binding]
216595009049	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
216595009050	active site
216595009051	dimer interface [polypeptide binding]; other site
216595009053	PS00156 Orotidine 5'-phosphate decarboxylase active site.
216595009054	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
216595009055	Prostaglandin dehydrogenases; Region: PGDH; cd05288
216595009056	NAD(P) binding site [chemical binding]; other site
216595009057	substrate binding site [chemical binding]; other site
216595009058	dimer interface [polypeptide binding]; other site
216595009060	PS00017 ATP/GTP-binding site motif A (P-loop).
216595009061	short chain dehydrogenase; Provisional; Region: PRK06172
216595009062	classical (c) SDRs; Region: SDR_c; cd05233
216595009063	NAD(P) binding site [chemical binding]; other site
216595009064	active site
216595009066	PS00061 Short-chain dehydrogenases/reductases family signature.
216595009067	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
216595009068	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595009069	DNA-binding site [nucleotide binding]; DNA binding site
216595009070	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216595009071	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595009072	homodimer interface [polypeptide binding]; other site
216595009073	catalytic residue [active]
216595009076	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595009077	dimerization interface [polypeptide binding]; other site
216595009078	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
216595009079	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595009080	dimer interface [polypeptide binding]; other site
216595009081	putative CheW interface [polypeptide binding]; other site
216595009082	2 probable transmembrane helices predicted for PFLU1855 by TMHMM2.0 at aa 41-63 and 326-348
216595009085	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
216595009087	Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063
216595009088	1 probable transmembrane helix predicted for PFLU1858 by TMHMM2.0 at aa 4-26
216595009089	hypothetical protein; Provisional; Region: PRK06156
216595009090	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
216595009091	metal binding site [ion binding]; metal-binding site
216595009094	PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1.
216595009095	1 probable transmembrane helix predicted for PFLU1859 by TMHMM2.0 at aa 7-29
216595009096	hypothetical protein; Provisional; Region: PRK06156
216595009097	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
216595009098	active site
216595009099	metal binding site [ion binding]; metal-binding site
216595009102	PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1.
216595009103	PS00017 ATP/GTP-binding site motif A (P-loop).
216595009104	alanine-tRNA ligase; Region: PLN02961
216595009105	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
216595009107	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595009108	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
216595009109	putative effector binding pocket; other site
216595009110	dimerization interface [polypeptide binding]; other site
216595009113	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
216595009114	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
216595009115	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
216595009116	active site
216595009117	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
216595009121	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
216595009122	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
216595009123	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
216595009124	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
216595009125	putative C-terminal domain interface [polypeptide binding]; other site
216595009126	putative GSH binding site (G-site) [chemical binding]; other site
216595009127	putative dimer interface [polypeptide binding]; other site
216595009128	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
216595009129	putative N-terminal domain interface [polypeptide binding]; other site
216595009130	putative dimer interface [polypeptide binding]; other site
216595009131	putative substrate binding pocket (H-site) [chemical binding]; other site
216595009134	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
216595009135	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216595009136	Walker A/P-loop; other site
216595009137	ATP binding site [chemical binding]; other site
216595009138	Q-loop/lid; other site
216595009139	ABC transporter signature motif; other site
216595009140	Walker B; other site
216595009141	D-loop; other site
216595009142	H-loop/switch region; other site
216595009144	PS00017 ATP/GTP-binding site motif A (P-loop).
216595009145	PS00211 ABC transporters family signature.
216595009146	inner membrane transport permease; Provisional; Region: PRK15066
216595009147	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
216595009149	6 probable transmembrane helices predicted for PFLU1869 by TMHMM2.0 at aa 31-50, 65-87, 108-130, 145-167, 174-196 and 231-253
216595009150	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
216595009151	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216595009153	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595009154	Major Facilitator Superfamily; Region: MFS_1; pfam07690
216595009155	12 probable transmembrane helices predicted for PFLU1871 by TMHMM2.0 at aa 12-34, 44-66, 78-95, 105-125, 132-154, 164-181, 210-232, 245-267, 274-293, 298-320, 333-355 and 370-387
216595009157	PS00216 Sugar transport proteins signature 1.
216595009158	Cupin domain; Region: Cupin_2; cl17218
216595009160	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318
216595009161	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
216595009162	gating phenylalanine in ion channel; other site
216595009163	10 probable transmembrane helices predicted for PFLU1873 by TMHMM2.0 at aa 27-49, 59-81, 94-116, 131-153, 166-188, 198-220, 233-255, 275-297, 309-326 and 336-358
216595009165	H+ Antiporter protein; Region: 2A0121; TIGR00900
216595009166	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595009167	putative substrate translocation pore; other site
216595009168	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
216595009169	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
216595009170	putative acyl-acceptor binding pocket; other site
216595009172	11 probable transmembrane helices predicted for PFLU1874 by TMHMM2.0 at aa 52-71, 83-105, 110-132, 145-167, 172-191, 232-254, 264-286, 293-315, 338-360, 373-395 and 405-424
216595009174	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
216595009176	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
216595009177	Sodium Bile acid symporter family; Region: SBF; pfam01758
216595009180	recombination associated protein; Reviewed; Region: rdgC; PRK00321
216595009182	1/3 vs 2/3
216595009183	PFI-5
216595009184	integrase; Provisional; Region: PRK09692
216595009185	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
216595009186	active site
216595009187	Int/Topo IB signature motif; other site
216595009189	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
216595009190	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
216595009191	putative active site [active]
216595009192	putative metal binding site [ion binding]; other site
216595009193	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
216595009195	PS00017 ATP/GTP-binding site motif A (P-loop).
216595009196	Transposase; Region: HTH_Tnp_1; pfam01527
216595009197	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
216595009199	PS00216 Sugar transport proteins signature 1.
216595009200	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
216595009201	Integrase core domain; Region: rve; pfam00665
216595009203	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
216595009204	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595009205	Walker A motif; other site
216595009206	ATP binding site [chemical binding]; other site
216595009207	Walker B motif; other site
216595009208	arginine finger; other site
216595009210	PS00017 ATP/GTP-binding site motif A (P-loop).
216595009211	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
216595009212	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
216595009215	PS00017 ATP/GTP-binding site motif A (P-loop).
216595009216	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130
216595009217	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
216595009218	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
216595009219	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
216595009221	PS00190 Cytochrome c family heme-binding site signature.
216595009222	PS00190 Cytochrome c family heme-binding site signature.
216595009224	PS00190 Cytochrome c family heme-binding site signature.
216595009225	1 probable transmembrane helix predicted for PFLU1891 by TMHMM2.0 at aa 13-35
216595009226	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
216595009227	Low-spin heme binding site [chemical binding]; other site
216595009228	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
216595009229	D-pathway; other site
216595009230	Putative water exit pathway; other site
216595009231	Binuclear center (active site) [active]
216595009232	K-pathway; other site
216595009233	Putative proton exit pathway; other site
216595009235	Cytochrome c; Region: Cytochrom_C; pfam00034
216595009237	PS00190 Cytochrome c family heme-binding site signature.
216595009238	1 probable transmembrane helix predicted for PFLU1893 by TMHMM2.0 at aa 15-37
216595009239	PS00190 Cytochrome c family heme-binding site signature.
216595009240	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
216595009241	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
216595009242	Moco binding site; other site
216595009243	metal coordination site [ion binding]; other site
216595009246	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
216595009247	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
216595009248	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
216595009249	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
216595009250	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595009251	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
216595009252	putative dimerization interface [polypeptide binding]; other site
216595009255	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318
216595009256	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
216595009257	gating phenylalanine in ion channel; other site
216595009259	10 probable transmembrane helices predicted for PFLU1898 by TMHMM2.0 at aa 32-54, 64-86, 98-120, 135-157, 170-192, 202-224, 237-259, 279-301, 313-330 and 340-362
216595009260	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035
216595009261	putative uracil binding site [chemical binding]; other site
216595009262	putative active site [active]
216595009263	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
216595009265	9 probable transmembrane helices predicted for PFLU1900 by TMHMM2.0 at aa 28-50, 62-84, 104-126, 133-155, 194-216, 223-245, 330-352, 365-387 and 414-436
216595009266	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
216595009267	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
216595009268	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
216595009270	8 probable transmembrane helices predicted for PFLU1901 by TMHMM2.0 at aa 7-26, 74-96, 117-139, 159-181, 194-216, 231-253, 260-282 and 302-324
216595009271	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
216595009272	dimer interface [polypeptide binding]; other site
216595009273	substrate binding site [chemical binding]; other site
216595009274	metal binding sites [ion binding]; metal-binding site
216595009276	PS00387 Inorganic pyrophosphatase signature.
216595009277	enolase; Provisional; Region: eno; PRK00077
216595009278	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
216595009279	dimer interface [polypeptide binding]; other site
216595009280	metal binding site [ion binding]; metal-binding site
216595009281	substrate binding pocket [chemical binding]; other site
216595009283	PS00164 Enolase signature.
216595009285	1 probable transmembrane helix predicted for PFLU1905 by TMHMM2.0 at aa 21-40
216595009286	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
216595009287	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
216595009288	ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682
216595009289	putative Cl- selectivity filter; other site
216595009290	putative pore gating glutamate residue; other site
216595009292	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
216595009294	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
216595009295	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
216595009297	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
216595009298	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
216595009299	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
216595009300	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
216595009301	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
216595009303	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
216595009304	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
216595009305	putative active site [active]
216595009306	putative NTP binding site [chemical binding]; other site
216595009307	putative nucleic acid binding site [nucleotide binding]; other site
216595009308	AAA domain; Region: AAA_23; pfam13476
216595009309	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216595009310	Walker A/P-loop; other site
216595009311	ATP binding site [chemical binding]; other site
216595009312	PS00017 ATP/GTP-binding site motif A (P-loop).
216595009313	PS00017 ATP/GTP-binding site motif A (P-loop).
216595009314	integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760
216595009315	Putative helicase; Region: TraI_2; pfam07514
216595009316	Protein of unknown function (DUF1528); Region: DUF1528; pfam07515
216595009319	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
216595009320	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
216595009322	1 probable transmembrane helix predicted for PFLU1919 by TMHMM2.0 at aa 64-86
216595009323	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
216595009324	PS00017 ATP/GTP-binding site motif A (P-loop).
216595009325	integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755
216595009326	integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756
216595009328	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
216595009329	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216595009330	non-specific DNA binding site [nucleotide binding]; other site
216595009331	salt bridge; other site
216595009332	sequence-specific DNA binding site [nucleotide binding]; other site
216595009334	PS00045 Bacterial histone-like DNA-binding proteins signature.
216595009335	conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744
216595009336	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
216595009337	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
216595009338	Walker A motif; other site
216595009339	ATP binding site [chemical binding]; other site
216595009340	Walker B motif; other site
216595009341	arginine finger; other site
216595009342	PS00017 ATP/GTP-binding site motif A (P-loop).
216595009343	conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751
216595009344	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595009345	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
216595009346	Protein of unknown function (DUF904); Region: DUF904; pfam06005
216595009347	1 probable transmembrane helix predicted for PFLU1929 by TMHMM2.0 at aa 23-45
216595009348	integrating conjugative element protein, PFL_4704 family; Region: conj_TIGR03749
216595009349	integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746
216595009350	1 probable transmembrane helix predicted for PFLU1931 by TMHMM2.0 at aa 20-39
216595009351	Protein of unknown function (DUF3487); Region: DUF3487; pfam11990
216595009352	integrating conjugative element membrane protein, PFL_4702 family; Region: conj_TIGR03745
216595009353	Protein of unknown function (DUF3262); Region: DUF3262; pfam11660
216595009354	integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690
216595009355	Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686
216595009356	succinic semialdehyde dehydrogenase; Region: PLN02278
216595009357	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
216595009358	tetramerization interface [polypeptide binding]; other site
216595009359	NAD(P) binding site [chemical binding]; other site
216595009360	catalytic residues [active]
216595009362	PS00070 Aldehyde dehydrogenases cysteine active site.
216595009363	PS00687 Aldehyde dehydrogenases glutamic acid active site.
216595009364	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
216595009365	dimer interface [polypeptide binding]; other site
216595009366	catalytic residue [active]
216595009368	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595009369	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
216595009370	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
216595009372	Transcriptional regulators [Transcription]; Region: FadR; COG2186
216595009373	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
216595009374	DNA-binding site [nucleotide binding]; DNA binding site
216595009375	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
216595009378	hypothetical protein; Provisional; Region: PRK06847
216595009379	hypothetical protein; Provisional; Region: PRK07236
216595009380	PS00216 Sugar transport proteins signature 1.
216595009382	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
216595009383	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
216595009384	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
216595009385	iron-sulfur cluster [ion binding]; other site
216595009386	[2Fe-2S] cluster binding site [ion binding]; other site
216595009388	C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360
216595009389	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
216595009390	putative active site [active]
216595009391	putative metal binding site [ion binding]; other site
216595009393	PS00934 Glyoxalase I signature 1.
216595009394	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595009395	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595009396	The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462
216595009397	putative substrate binding pocket [chemical binding]; other site
216595009398	putative dimerization interface [polypeptide binding]; other site
216595009401	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
216595009403	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
216595009404	histidinol dehydrogenase; Region: hisD; TIGR00069
216595009405	NAD binding site [chemical binding]; other site
216595009406	dimerization interface [polypeptide binding]; other site
216595009407	product binding site; other site
216595009408	substrate binding site [chemical binding]; other site
216595009409	zinc binding site [ion binding]; other site
216595009410	catalytic residues [active]
216595009412	classical (c) SDRs; Region: SDR_c; cd05233
216595009413	NAD(P) binding site [chemical binding]; other site
216595009414	active site
216595009416	PS00061 Short-chain dehydrogenases/reductases family signature.
216595009417	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
216595009418	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
216595009420	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
216595009421	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216595009422	NAD(P) binding site [chemical binding]; other site
216595009423	active site
216595009425	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595009426	Major Facilitator Superfamily; Region: MFS_1; pfam07690
216595009427	putative substrate translocation pore; other site
216595009428	12 probable transmembrane helices predicted for PFLU1953 by TMHMM2.0 at aa 13-35, 50-72, 84-103, 108-130, 142-164, 168-190, 211-233, 248-270, 277-299, 304-326, 339-361 and 366-388
216595009430	PS00216 Sugar transport proteins signature 1.
216595009431	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
216595009432	classical (c) SDRs; Region: SDR_c; cd05233
216595009433	NAD(P) binding site [chemical binding]; other site
216595009434	active site
216595009435	PS00017 ATP/GTP-binding site motif A (P-loop).
216595009437	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
216595009440	1 probable transmembrane helix predicted for PFLU1956 by TMHMM2.0 at aa 9-31
216595009441	Transcriptional regulators [Transcription]; Region: FadR; COG2186
216595009442	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595009443	DNA-binding site [nucleotide binding]; DNA binding site
216595009444	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
216595009448	integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747
216595009449	conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743
216595009450	conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754
216595009451	PS00017 ATP/GTP-binding site motif A (P-loop).
216595009452	1 probable transmembrane helix predicted for PFLU1961 by TMHMM2.0 at aa 13-35
216595009453	Protein of unknown function (DUF2859); Region: DUF2859; pfam11072
216595009455	integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759
216595009456	1 probable transmembrane helix predicted for PFLU1964 by TMHMM2.0 at aa 4-26
216595009457	1 probable transmembrane helix predicted for PFLU1965 by TMHMM2.0 at aa 4-26
216595009458	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595009459	hypothetical protein; Reviewed; Region: PRK00024
216595009460	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
216595009461	MPN+ (JAMM) motif; other site
216595009462	Zinc-binding site [ion binding]; other site
216595009464	PS01302 DNA repair protein radC family signature.
216595009465	Protein of unknown function (DUF3577); Region: DUF3577; pfam12101
216595009466	DNA topoisomerase III; Provisional; Region: PRK07726
216595009467	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
216595009468	active site
216595009469	putative interdomain interaction site [polypeptide binding]; other site
216595009470	putative metal-binding site [ion binding]; other site
216595009471	putative nucleotide binding site [chemical binding]; other site
216595009472	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
216595009473	domain I; other site
216595009474	DNA binding groove [nucleotide binding]
216595009475	phosphate binding site [ion binding]; other site
216595009476	domain II; other site
216595009477	domain III; other site
216595009478	nucleotide binding site [chemical binding]; other site
216595009479	catalytic site [active]
216595009480	domain IV; other site
216595009481	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
216595009485	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
216595009486	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
216595009487	dimer interface [polypeptide binding]; other site
216595009488	ssDNA binding site [nucleotide binding]; other site
216595009489	tetramer (dimer of dimers) interface [polypeptide binding]; other site
216595009491	Protein of unknown function (DUF3158); Region: DUF3158; pfam11358
216595009492	integrating conjugative element protein, PFL_4669 family; Region: ICE_PFL4669; TIGR03761
216595009494	Protein of unknown function (DUF2857); Region: DUF2857; pfam11198
216595009495	integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764
216595009496	ParB-like nuclease domain; Region: ParBc; pfam02195
216595009497	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
216595009499	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
216595009500	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
216595009501	Magnesium ion binding site [ion binding]; other site
216595009503	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930
216595009505	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
216595009506	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
216595009507	catalytic residues [active]
216595009509	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
216595009510	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
216595009511	active site
216595009512	FMN binding site [chemical binding]; other site
216595009513	substrate binding site [chemical binding]; other site
216595009514	putative catalytic residue [active]
216595009516	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595009517	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595009518	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
216595009519	putative effector binding pocket; other site
216595009520	dimerization interface [polypeptide binding]; other site
216595009523	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
216595009524	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
216595009525	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
216595009526	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
216595009529	PS00017 ATP/GTP-binding site motif A (P-loop).
216595009530	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
216595009531	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216595009532	NAD(P) binding site [chemical binding]; other site
216595009533	active site
216595009535	PS00061 Short-chain dehydrogenases/reductases family signature.
216595009536	1 probable transmembrane helix predicted for PFLU1988 by TMHMM2.0 at aa 21-40
216595009537	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
216595009538	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216595009539	NAD(P) binding site [chemical binding]; other site
216595009540	active site
216595009541	PS00017 ATP/GTP-binding site motif A (P-loop).
216595009543	PS00061 Short-chain dehydrogenases/reductases family signature.
216595009544	benzoate transport; Region: 2A0115; TIGR00895
216595009545	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595009547	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595009548	PS00216 Sugar transport proteins signature 1.
216595009549	Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938
216595009550	active site
216595009551	catalytic site [active]
216595009552	Zn binding site [ion binding]; other site
216595009553	tetramer interface [polypeptide binding]; other site
216595009554	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
216595009556	hypothetical protein; Provisional; Region: PRK06102
216595009557	Amidase; Region: Amidase; cl11426
216595009559	PS00017 ATP/GTP-binding site motif A (P-loop).
216595009560	Transcriptional regulators [Transcription]; Region: GntR; COG1802
216595009561	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595009562	DNA-binding site [nucleotide binding]; DNA binding site
216595009563	Transcriptional regulators [Transcription]; Region: GntR; COG1802
216595009564	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595009565	DNA-binding site [nucleotide binding]; DNA binding site
216595009566	FCD domain; Region: FCD; pfam07729
216595009568	PS00043 Bacterial regulatory proteins, gntR family signature.
216595009571	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595009572	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595009573	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
216595009574	putative substrate binding pocket [chemical binding]; other site
216595009575	dimerization interface [polypeptide binding]; other site
216595009578	PS00044 Bacterial regulatory proteins, lysR family signature.
216595009579	uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_2; cd11664
216595009580	putative active site [active]
216595009582	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
216595009583	carboxyltransferase (CT) interaction site; other site
216595009584	biotinylation site [posttranslational modification]; other site
216595009586	acetyl-CoA carboxylase biotin carboxylase subunit; Provisional; Region: PRK12833
216595009587	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
216595009588	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
216595009589	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
216595009592	PS00866 Carbamoyl-phosphate synthase subdomain signature 1.
216595009593	PS00867 Carbamoyl-phosphate synthase subdomain signature 2.
216595009595	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
216595009596	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
216595009598	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
216595009600	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
216595009601	11 probable transmembrane helices predicted for PFLU2000 by TMHMM2.0 at aa 38-60, 65-87, 99-121, 136-158, 170-192, 207-229, 242-264, 279-301, 322-344, 354-376 and 389-411
216595009602	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
216595009603	1 probable transmembrane helix predicted for PFLU2001 by TMHMM2.0 at aa 12-31
216595009604	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595009605	PAS fold; Region: PAS_3; pfam08447
216595009606	putative active site [active]
216595009607	heme pocket [chemical binding]; other site
216595009608	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595009609	PAS fold; Region: PAS_3; pfam08447
216595009610	putative active site [active]
216595009611	heme pocket [chemical binding]; other site
216595009612	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595009613	putative CheW interface [polypeptide binding]; other site
216595009617	Short chain fatty acid transporter; Region: SCFA_trans; cl17380
216595009619	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
216595009620	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
216595009621	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595009622	catalytic residue [active]
216595009624	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
216595009625	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
216595009626	AsnC family; Region: AsnC_trans_reg; pfam01037
216595009627	PS00519 Bacterial regulatory proteins, asnC family signature.
216595009629	homoserine dehydrogenase; Provisional; Region: PRK06270
216595009630	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
216595009632	PS01042 Homoserine dehydrogenase signature.
216595009633	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
216595009634	Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149
216595009635	NAD(P) binding site [chemical binding]; other site
216595009636	catalytic residues [active]
216595009638	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
216595009640	12 probable transmembrane helices predicted for PFLU2013 by TMHMM2.0 at aa 21-38, 42-64, 87-109, 129-151, 164-186, 206-228, 249-271, 275-297, 335-357, 367-389, 409-428 and 433-450
216595009641	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595009642	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595009643	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595009644	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
216595009645	dimerization interface [polypeptide binding]; other site
216595009648	PS00044 Bacterial regulatory proteins, lysR family signature.
216595009649	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
216595009650	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595009651	putative substrate translocation pore; other site
216595009652	12 probable transmembrane helices predicted for PFLU2015 by TMHMM2.0 at aa 23-40, 62-84, 97-119, 123-145, 152-174, 189-208, 249-271, 281-303, 315-334, 338-360, 373-395 and 405-427
216595009654	Uncharacterized conserved protein [Function unknown]; Region: COG5476
216595009655	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
216595009656	MlrC C-terminus; Region: MlrC_C; pfam07171
216595009659	PS00294 Prenyl group binding site (CAAX box).
216595009661	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
216595009662	5 probable transmembrane helices predicted for PFLU2019 by TMHMM2.0 at aa 23-45, 57-79, 89-111, 146-168 and 172-194
216595009664	BCCT family transporter; Region: BCCT; pfam02028
216595009665	12 probable transmembrane helices predicted for PFLU2021 by TMHMM2.0 at aa 26-45, 65-87, 107-126, 157-179, 211-233, 248-267, 280-302, 332-351, 363-385, 417-439, 465-487 and 497-516
216595009667	X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129
216595009668	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
216595009669	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
216595009672	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
216595009673	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595009674	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
216595009675	dimerization interface [polypeptide binding]; other site
216595009677	PS00044 Bacterial regulatory proteins, lysR family signature.
216595009679	1 probable transmembrane helix predicted for PFLU2024 by TMHMM2.0 at aa 5-27
216595009680	Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152
216595009681	putative heme binding pocket [chemical binding]; other site
216595009682	1 probable transmembrane helix predicted for PFLU2025 by TMHMM2.0 at aa 27-49
216595009683	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
216595009684	PS00190 Cytochrome c family heme-binding site signature.
216595009686	PS00190 Cytochrome c family heme-binding site signature.
216595009687	1 probable transmembrane helix predicted for PFLU2026 by TMHMM2.0 at aa 26-48
216595009688	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
216595009689	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
216595009690	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
216595009691	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595009694	PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1.
216595009695	PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2.
216595009696	Protein of unknown function (DUF1232); Region: DUF1232; pfam06803
216595009698	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216595009699	non-specific DNA binding site [nucleotide binding]; other site
216595009700	salt bridge; other site
216595009701	sequence-specific DNA binding site [nucleotide binding]; other site
216595009703	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
216595009704	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
216595009705	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
216595009706	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216595009707	metal binding site [ion binding]; metal-binding site
216595009708	active site
216595009709	I-site; other site
216595009713	carboxy-terminal protease; Provisional; Region: PRK11186
216595009714	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
216595009715	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
216595009716	protein binding site [polypeptide binding]; other site
216595009717	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
216595009718	Catalytic dyad [active]
216595009719	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
216595009722	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
216595009723	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
216595009724	NAD(P) binding site [chemical binding]; other site
216595009727	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
216595009728	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
216595009730	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
216595009731	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216595009732	Walker A/P-loop; other site
216595009733	ATP binding site [chemical binding]; other site
216595009734	Q-loop/lid; other site
216595009735	ABC transporter signature motif; other site
216595009736	Walker B; other site
216595009737	D-loop; other site
216595009738	H-loop/switch region; other site
216595009739	TOBE domain; Region: TOBE_2; pfam08402
216595009742	PS00211 ABC transporters family signature.
216595009743	PS00017 ATP/GTP-binding site motif A (P-loop).
216595009744	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
216595009745	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595009746	dimer interface [polypeptide binding]; other site
216595009747	conserved gate region; other site
216595009748	ABC-ATPase subunit interface; other site
216595009750	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595009751	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595009752	dimer interface [polypeptide binding]; other site
216595009753	conserved gate region; other site
216595009754	putative PBP binding loops; other site
216595009755	ABC-ATPase subunit interface; other site
216595009757	Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524
216595009759	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
216595009760	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
216595009761	transcriptional regulator protein; Region: phnR; TIGR03337
216595009762	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595009763	DNA-binding site [nucleotide binding]; DNA binding site
216595009764	UTRA domain; Region: UTRA; pfam07702
216595009766	PS00043 Bacterial regulatory proteins, gntR family signature.
216595009768	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
216595009769	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
216595009770	intersubunit interface [polypeptide binding]; other site
216595009772	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595009773	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
216595009774	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
216595009775	ABC-ATPase subunit  interface; other site
216595009776	dimer interface [polypeptide binding]; other site
216595009777	putative PBP binding regions; other site
216595009779	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
216595009780	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
216595009782	PS00211 ABC transporters family signature.
216595009783	PS00017 ATP/GTP-binding site motif A (P-loop).
216595009784	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
216595009785	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
216595009786	metal binding site [ion binding]; metal-binding site
216595009788	1 probable transmembrane helix predicted for PFLU2045 by TMHMM2.0 at aa 17-36
216595009789	1 probable transmembrane helix predicted for PFLU2047 by TMHMM2.0 at aa 21-40
216595009790	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
216595009791	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
216595009792	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
216595009793	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
216595009798	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
216595009799	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
216595009800	substrate binding site [chemical binding]; other site
216595009801	ligand binding site [chemical binding]; other site
216595009803	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595009804	PS00450 Aconitase family signature 1.
216595009805	PS01244 Aconitase family signature 2.
216595009806	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
216595009807	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
216595009808	substrate binding site [chemical binding]; other site
216595009811	transcriptional activator TtdR; Provisional; Region: PRK09801
216595009812	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595009813	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
216595009814	putative effector binding pocket; other site
216595009815	putative dimerization interface [polypeptide binding]; other site
216595009818	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
216595009820	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
216595009821	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
216595009822	DNA binding residues [nucleotide binding]
216595009823	dimer interface [polypeptide binding]; other site
216595009824	[2Fe-2S] cluster binding site [ion binding]; other site
216595009827	PS00552 Bacterial regulatory proteins, merR family signature.
216595009828	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
216595009829	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
216595009830	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595009831	Walker A motif; other site
216595009832	ATP binding site [chemical binding]; other site
216595009833	Walker B motif; other site
216595009834	arginine finger; other site
216595009835	PS00688 Sigma-54 interaction domain C-terminal part signature.
216595009837	PS00676 Sigma-54 interaction domain ATP-binding region B signature.
216595009838	PS00675 Sigma-54 interaction domain ATP-binding region A signature.
216595009839	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
216595009840	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
216595009841	Flavin binding site [chemical binding]; other site
216595009843	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
216595009844	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
216595009845	active site
216595009846	dimer interface [polypeptide binding]; other site
216595009847	non-prolyl cis peptide bond; other site
216595009848	insertion regions; other site
216595009850	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
216595009851	FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566
216595009853	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
216595009854	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
216595009855	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
216595009856	catalytic residue [active]
216595009858	PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site.
216595009859	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595009860	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
216595009861	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
216595009862	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
216595009863	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
216595009864	active site
216595009867	1 probable transmembrane helix predicted for PFLU2062 by TMHMM2.0 at aa 44-61
216595009868	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595009869	threonine and homoserine efflux system; Provisional; Region: PRK10532
216595009870	EamA-like transporter family; Region: EamA; pfam00892
216595009872	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
216595009873	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
216595009874	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
216595009875	1 probable transmembrane helix predicted for PFLU2064 by TMHMM2.0 at aa 108-130
216595009877	PS00017 ATP/GTP-binding site motif A (P-loop).
216595009879	Uncharacterized conserved protein [Function unknown]; Region: COG3791
216595009881	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898
216595009882	putative hydrophobic ligand binding site [chemical binding]; other site
216595009884	PS00017 ATP/GTP-binding site motif A (P-loop).
216595009885	DNA polymerase II; Reviewed; Region: PRK05762
216595009886	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
216595009887	active site
216595009888	catalytic site [active]
216595009889	substrate binding site [chemical binding]; other site
216595009890	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
216595009891	active site
216595009892	metal-binding site
216595009895	PS00116 DNA polymerase family B signature.
216595009896	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
216595009897	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
216595009899	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
216595009900	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
216595009901	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
216595009902	N-terminal domain interface [polypeptide binding]; other site
216595009903	dimer interface [polypeptide binding]; other site
216595009904	substrate binding pocket (H-site) [chemical binding]; other site
216595009906	Domain of unknown function (DUF4174); Region: DUF4174; pfam13778
216595009907	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
216595009908	Acyltransferase family; Region: Acyl_transf_3; pfam01757
216595009910	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
216595009912	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
216595009913	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
216595009914	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
216595009916	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
216595009917	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
216595009919	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664
216595009921	1 probable transmembrane helix predicted for PFLU2076 by TMHMM2.0 at aa 7-24
216595009922	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
216595009923	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
216595009925	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
216595009926	Chain length determinant protein; Region: Wzz; cl15801
216595009928	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
216595009929	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
216595009931	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595009932	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
216595009933	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
216595009934	active site
216595009935	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
216595009937	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
216595009938	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
216595009939	Substrate binding site; other site
216595009940	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
216595009943	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
216595009944	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
216595009946	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
216595009947	6 probable transmembrane helices predicted for PFLU2084 by TMHMM2.0 at aa 38-60, 73-95, 105-122, 141-163, 178-200 and 213-235
216595009950	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
216595009951	conserved cys residue [active]
216595009953	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
216595009954	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
216595009955	conserved cys residue [active]
216595009956	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595009957	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595009960	PS00041 Bacterial regulatory proteins, araC family signature.
216595009962	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
216595009963	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595009965	PS00340 Growth factor and cytokines receptors family signature 2.
216595009966	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
216595009967	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
216595009969	glucose-1-dehydrogenase; Provisional; Region: PRK08936
216595009970	glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358
216595009971	NAD binding site [chemical binding]; other site
216595009972	homodimer interface [polypeptide binding]; other site
216595009973	active site
216595009975	PS00061 Short-chain dehydrogenases/reductases family signature.
216595009976	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
216595009977	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216595009978	motif II; other site
216595009980	Class I aldolases; Region: Aldolase_Class_I; cl17187
216595009981	catalytic residue [active]
216595009982	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
216595009983	classical (c) SDRs; Region: SDR_c; cd05233
216595009984	NAD(P) binding site [chemical binding]; other site
216595009985	active site
216595009987	PS00017 ATP/GTP-binding site motif A (P-loop).
216595009988	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216595009989	NAD(P) binding site [chemical binding]; other site
216595009990	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595009991	S-adenosylmethionine binding site [chemical binding]; other site
216595009993	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595009994	putative substrate translocation pore; other site
216595009995	Major Facilitator Superfamily; Region: MFS_1; pfam07690
216595009996	11 probable transmembrane helices predicted for PFLU2096 by TMHMM2.0 at aa 20-42, 55-77, 106-128, 145-167, 171-193, 222-244, 259-281, 288-307, 312-334, 347-369 and 379-398
216595009998	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595009999	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
216595010000	ligand-binding site [chemical binding]; other site
216595010002	PS00017 ATP/GTP-binding site motif A (P-loop).
216595010003	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
216595010004	CGNR zinc finger; Region: zf-CGNR; pfam11706
216595010006	ggaaccnnnnnnnnnnnnnnnnccacnna
216595010008	diaminopimelate epimerase; Provisional; Region: PRK13577
216595010010	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
216595010011	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
216595010012	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
216595010014	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
216595010015	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595010016	Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519
216595010017	active site flap/lid [active]
216595010018	nucleophilic elbow; other site
216595010019	catalytic triad [active]
216595010021	cytosine deaminase; Provisional; Region: PRK09230
216595010022	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
216595010023	active site
216595010025	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595010026	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
216595010027	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
216595010029	cytosine permease; Provisional; Region: codB; PRK11017
216595010030	Na binding site [ion binding]; other site
216595010032	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
216595010033	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
216595010034	nudix motif; other site
216595010037	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216595010038	non-specific DNA binding site [nucleotide binding]; other site
216595010039	salt bridge; other site
216595010040	sequence-specific DNA binding site [nucleotide binding]; other site
216595010042	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
216595010043	active site
216595010045	Predicted membrane protein [Function unknown]; Region: COG3212
216595010046	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
216595010048	Predicted membrane protein [Function unknown]; Region: COG3212
216595010049	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
216595010051	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
216595010052	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595010053	active site
216595010054	phosphorylation site [posttranslational modification]
216595010055	intermolecular recognition site; other site
216595010056	dimerization interface [polypeptide binding]; other site
216595010057	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216595010058	DNA binding site [nucleotide binding]
216595010061	sensor protein PhoQ; Provisional; Region: PRK10815
216595010062	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595010063	ATP binding site [chemical binding]; other site
216595010064	G-X-G motif; other site
216595010065	2 probable transmembrane helices predicted for PFLU2122 by TMHMM2.0 at aa 7-29 and 152-171
216595010069	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595010070	dimerization interface [polypeptide binding]; other site
216595010071	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
216595010072	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595010073	dimer interface [polypeptide binding]; other site
216595010074	putative CheW interface [polypeptide binding]; other site
216595010077	Predicted permease [General function prediction only]; Region: COG2056
216595010078	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
216595010079	C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322
216595010080	12 probable transmembrane helices predicted for PFLU2124 by TMHMM2.0 at aa 35-57, 62-84, 91-113, 161-180, 192-214, 234-256, 277-299, 303-322, 335-357, 377-399, 406-428 and 457-479
216595010082	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
216595010083	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595010084	dimerization interface [polypeptide binding]; other site
216595010085	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
216595010086	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595010087	dimer interface [polypeptide binding]; other site
216595010088	putative CheW interface [polypeptide binding]; other site
216595010089	2 probable transmembrane helices predicted for PFLU2125 by TMHMM2.0 at aa 10-32 and 205-227
216595010093	putative protease; Provisional; Region: PRK15452
216595010094	Peptidase family U32; Region: Peptidase_U32; pfam01136
216595010096	PS01276 Peptidase family U32 signature.
216595010097	Protein of unknown function (DUF2790); Region: DUF2790; pfam10976
216595010098	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
216595010099	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
216595010100	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
216595010101	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
216595010102	catalytic residues [active]
216595010103	5 probable transmembrane helices predicted for PFLU2128 by TMHMM2.0 at aa 7-29, 39-61, 74-96, 120-142 and 154-176
216595010106	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
216595010107	Domain of unknown function DUF20; Region: UPF0118; pfam01594
216595010109	7 probable transmembrane helices predicted for PFLU2129 by TMHMM2.0 at aa 20-42, 63-85, 154-176, 214-233, 238-260, 267-289 and 309-343
216595010110	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
216595010111	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
216595010112	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
216595010113	shikimate binding site; other site
216595010114	NAD(P) binding site [chemical binding]; other site
216595010117	Protein of unknown function, DUF480; Region: DUF480; pfam04337
216595010119	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
216595010120	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
216595010121	Family description; Region: UvrD_C_2; pfam13538
216595010122	PS00017 ATP/GTP-binding site motif A (P-loop).
216595010123	PS00017 ATP/GTP-binding site motif A (P-loop).
216595010125	AAA domain; Region: AAA_30; pfam13604
216595010126	AAA domain; Region: AAA_11; pfam13086
216595010127	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
216595010128	AAA domain; Region: AAA_12; pfam13087
216595010129	PS00017 ATP/GTP-binding site motif A (P-loop).
216595010130	serine/threonine transporter SstT; Provisional; Region: PRK13628
216595010131	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
216595010133	PS00435 Peroxidases proximal heme-ligand signature.
216595010134	12 probable transmembrane helices predicted for PFLU2140 by TMHMM2.0 at aa 89-111, 131-153, 165-182, 186-208, 227-249, 253-275, 296-315, 330-352, 359-381, 385-407, 420-442 and 447-469
216595010135	putative arabinose transporter; Provisional; Region: PRK03545
216595010136	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595010137	putative substrate translocation pore; other site
216595010139	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
216595010140	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595010141	The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429
216595010142	putative dimerization interface [polypeptide binding]; other site
216595010144	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595010145	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
216595010146	7 probable transmembrane helices predicted for PFLU2143 by TMHMM2.0 at aa 15-37, 58-80, 85-103, 123-145, 160-182, 189-208 and 218-235
216595010148	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
216595010149	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
216595010150	C-terminal domain interface [polypeptide binding]; other site
216595010151	GSH binding site (G-site) [chemical binding]; other site
216595010152	dimer interface [polypeptide binding]; other site
216595010153	C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178
216595010154	dimer interface [polypeptide binding]; other site
216595010155	N-terminal domain interface [polypeptide binding]; other site
216595010158	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
216595010160	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
216595010161	dimer interface [polypeptide binding]; other site
216595010162	active site
216595010163	Schiff base residues; other site
216595010165	PS00169 Delta-aminolevulinic acid dehydratase active site.
216595010166	Protein of unknown function (DUF1615); Region: DUF1615; pfam07759
216595010167	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595010169	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
216595010170	1 probable transmembrane helix predicted for PFLU2149 by TMHMM2.0 at aa 234-253
216595010171	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595010172	acetyl-CoA acetyltransferase; Provisional; Region: PRK05656
216595010173	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
216595010174	dimer interface [polypeptide binding]; other site
216595010175	active site
216595010177	PS00099 Thiolases active site.
216595010178	PS00737 Thiolases signature 2.
216595010180	PS00098 Thiolases acyl-enzyme intermediate signature.
216595010181	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
216595010183	PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide.
216595010184	PS01274 CoA transferases signature 2.
216595010185	1 probable transmembrane helix predicted for PFLU2151 by TMHMM2.0 at aa 20-37
216595010186	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
216595010188	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595010189	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595010190	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
216595010191	putative dimerization interface [polypeptide binding]; other site
216595010193	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595010195	NAD-dependent deacetylase; Provisional; Region: PRK05333
216595010196	SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409
216595010197	NAD+ binding site [chemical binding]; other site
216595010198	substrate binding site [chemical binding]; other site
216595010199	Zn binding site [ion binding]; other site
216595010201	FOG: CBS domain [General function prediction only]; Region: COG0517
216595010202	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
216595010204	DNA topoisomerase III; Provisional; Region: PRK07726
216595010205	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
216595010206	active site
216595010207	putative interdomain interaction site [polypeptide binding]; other site
216595010208	putative metal-binding site [ion binding]; other site
216595010209	putative nucleotide binding site [chemical binding]; other site
216595010210	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
216595010211	domain I; other site
216595010212	DNA binding groove [nucleotide binding]
216595010213	phosphate binding site [ion binding]; other site
216595010214	domain II; other site
216595010215	domain III; other site
216595010216	nucleotide binding site [chemical binding]; other site
216595010217	catalytic site [active]
216595010218	domain IV; other site
216595010220	PS00396 Prokaryotic DNA topoisomerase I active site.
216595010222	Helix-turn-helix domain; Region: HTH_28; pfam13518
216595010223	Winged helix-turn helix; Region: HTH_29; pfam13551
216595010224	Homeodomain-like domain; Region: HTH_32; pfam13565
216595010225	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
216595010226	Integrase core domain; Region: rve; pfam00665
216595010227	Integrase core domain; Region: rve_3; pfam13683
216595010229	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595010230	putative substrate translocation pore; other site
216595010232	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595010233	PS00217 Sugar transport proteins signature 2.
216595010234	choline dehydrogenase; Validated; Region: PRK02106
216595010235	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
216595010238	PS00624 GMC oxidoreductases signature 2.
216595010239	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595010240	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595010241	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
216595010242	dimerization interface [polypeptide binding]; other site
216595010244	PS00044 Bacterial regulatory proteins, lysR family signature.
216595010246	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
216595010247	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
216595010248	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
216595010249	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
216595010251	PS00181 Glutamine synthetase putative ATP-binding region signature.
216595010252	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
216595010253	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216595010254	non-specific DNA binding site [nucleotide binding]; other site
216595010255	salt bridge; other site
216595010256	sequence-specific DNA binding site [nucleotide binding]; other site
216595010257	Cupin domain; Region: Cupin_2; pfam07883
216595010260	Transposase IS200 like; Region: Y1_Tnp; pfam01797
216595010262	Domain of unknown function (DUF3315); Region: DUF3315; pfam11776
216595010263	Protein of unknown function (DUF1652); Region: DUF1652; pfam07865
216595010264	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
216595010265	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
216595010266	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595010267	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
216595010268	putative active site [active]
216595010269	heme pocket [chemical binding]; other site
216595010270	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595010271	putative active site [active]
216595010272	heme pocket [chemical binding]; other site
216595010273	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
216595010274	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216595010275	DNA binding residues [nucleotide binding]
216595010276	dimerization interface [polypeptide binding]; other site
216595010280	4 probable transmembrane helices predicted for PFLU2170 by TMHMM2.0 at aa 21-43, 63-85, 98-120 and 297-319
216595010281	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
216595010282	N-acetyl-D-glucosamine binding site [chemical binding]; other site
216595010283	catalytic residue [active]
216595010284	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595010285	Predicted amidohydrolase [General function prediction only]; Region: COG0388
216595010286	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_2; cd07580
216595010287	putative active site [active]
216595010288	catalytic triad [active]
216595010289	putative dimer interface [polypeptide binding]; other site
216595010291	hydroxyglutarate oxidase; Provisional; Region: PRK11728
216595010292	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
216595010294	PS00147 Arginase family signature 1.
216595010296	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
216595010297	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
216595010299	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
216595010300	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
216595010302	PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2.
216595010303	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
216595010304	Coenzyme A binding pocket [chemical binding]; other site
216595010306	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
216595010307	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
216595010308	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
216595010309	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
216595010310	Soluble P-type ATPase [General function prediction only]; Region: COG4087
216595010311	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
216595010314	8 probable transmembrane helices predicted for PFLU2178 by TMHMM2.0 at aa 249-271, 291-313, 323-345, 709-731, 772-794, 807-826, 841-863 and 868-890
216595010316	PS00154 E1-E2 ATPases phosphorylation site.
216595010317	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
216595010318	MgtC family; Region: MgtC; pfam02308
216595010319	4 probable transmembrane helices predicted for PFLU2179 by TMHMM2.0 at aa 7-29, 39-56, 68-87 and 107-129
216595010321	PS00387 Inorganic pyrophosphatase signature.
216595010322	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
216595010323	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595010324	active site
216595010325	phosphorylation site [posttranslational modification]
216595010326	intermolecular recognition site; other site
216595010327	dimerization interface [polypeptide binding]; other site
216595010328	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216595010329	DNA binding residues [nucleotide binding]
216595010330	dimerization interface [polypeptide binding]; other site
216595010333	PS00622 Bacterial regulatory proteins, luxR family signature.
216595010334	hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959
216595010335	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595010336	substrate binding pocket [chemical binding]; other site
216595010337	membrane-bound complex binding site; other site
216595010338	hinge residues; other site
216595010339	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595010340	substrate binding pocket [chemical binding]; other site
216595010341	membrane-bound complex binding site; other site
216595010342	hinge residues; other site
216595010343	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595010344	putative active site [active]
216595010345	heme pocket [chemical binding]; other site
216595010346	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595010347	dimer interface [polypeptide binding]; other site
216595010348	phosphorylation site [posttranslational modification]
216595010349	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595010350	ATP binding site [chemical binding]; other site
216595010351	Mg2+ binding site [ion binding]; other site
216595010352	G-X-G motif; other site
216595010353	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595010354	active site
216595010355	phosphorylation site [posttranslational modification]
216595010356	intermolecular recognition site; other site
216595010357	dimerization interface [polypeptide binding]; other site
216595010358	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
216595010359	putative binding surface; other site
216595010360	active site
216595010361	1 probable transmembrane helix predicted for PFLU2181 by TMHMM2.0 at aa 537-559
216595010367	hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959
216595010368	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
216595010369	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
216595010370	active site
216595010371	catalytic tetrad [active]
216595010373	PS00062 Aldo/keto reductase family signature 2.
216595010375	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
216595010376	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
216595010378	Predicted amidohydrolase [General function prediction only]; Region: COG0388
216595010379	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
216595010380	active site
216595010381	catalytic triad [active]
216595010382	dimer interface [polypeptide binding]; other site
216595010384	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
216595010385	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216595010386	Coenzyme A binding pocket [chemical binding]; other site
216595010388	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216595010389	non-specific DNA binding site [nucleotide binding]; other site
216595010390	salt bridge; other site
216595010391	sequence-specific DNA binding site [nucleotide binding]; other site
216595010392	response regulator; Provisional; Region: PRK09483
216595010393	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595010394	active site
216595010395	phosphorylation site [posttranslational modification]
216595010396	intermolecular recognition site; other site
216595010397	dimerization interface [polypeptide binding]; other site
216595010398	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216595010399	DNA binding residues [nucleotide binding]
216595010400	dimerization interface [polypeptide binding]; other site
216595010403	PS00622 Bacterial regulatory proteins, luxR family signature.
216595010404	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
216595010405	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
216595010406	GIY-YIG motif/motif A; other site
216595010407	active site
216595010408	catalytic site [active]
216595010409	putative DNA binding site [nucleotide binding]; other site
216595010410	metal binding site [ion binding]; metal-binding site
216595010411	UvrB/uvrC motif; Region: UVR; pfam02151
216595010412	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
216595010417	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
216595010418	2 probable transmembrane helices predicted for PFLU2191 by TMHMM2.0 at aa 5-27 and 149-171
216595010420	PS00379 CDP-alcohol phosphatidyltransferases signature.
216595010421	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
216595010422	catalytic motif [active]
216595010423	Zn binding site [ion binding]; other site
216595010425	PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature.
216595010426	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
216595010428	L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434
216595010429	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
216595010430	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216595010431	Coenzyme A binding pocket [chemical binding]; other site
216595010432	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
216595010434	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
216595010435	PS00659 Glycosyl hydrolases family 5 signature.
216595010436	diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264
216595010437	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
216595010438	inhibitor-cofactor binding pocket; inhibition site
216595010439	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595010440	catalytic residue [active]
216595010442	PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site.
216595010443	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
216595010444	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
216595010445	metal binding site [ion binding]; metal-binding site
216595010448	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
216595010449	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
216595010450	Flavin binding site [chemical binding]; other site
216595010452	PS00225 Crystallins beta and gamma 'Greek key' motif signature.
216595010453	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595010454	D-galactonate transporter; Region: 2A0114; TIGR00893
216595010455	putative substrate translocation pore; other site
216595010457	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
216595010458	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216595010459	N-terminal plug; other site
216595010460	ligand-binding site [chemical binding]; other site
216595010463	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
216595010464	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
216595010465	substrate binding site [chemical binding]; other site
216595010466	oxyanion hole (OAH) forming residues; other site
216595010467	trimer interface [polypeptide binding]; other site
216595010469	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH5; cd08259
216595010470	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
216595010471	putative NAD(P) binding site [chemical binding]; other site
216595010472	catalytic Zn binding site [ion binding]; other site
216595010473	structural Zn binding site [ion binding]; other site
216595010475	PS00059 Zinc-containing alcohol dehydrogenases signature.
216595010477	PS01162 Quinone oxidoreductase / zeta-crystallin signature.
216595010478	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
216595010479	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
216595010480	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
216595010481	acyl-activating enzyme (AAE) consensus motif; other site
216595010482	acyl-activating enzyme (AAE) consensus motif; other site
216595010483	AMP binding site [chemical binding]; other site
216595010484	active site
216595010485	CoA binding site [chemical binding]; other site
216595010487	PS00455 Putative AMP-binding domain signature.
216595010488	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
216595010489	Transcriptional regulator [Transcription]; Region: IclR; COG1414
216595010492	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
216595010493	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216595010494	NAD(P) binding site [chemical binding]; other site
216595010495	active site
216595010497	1 probable transmembrane helix predicted for PFLU2208 by TMHMM2.0 at aa 7-25
216595010498	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595010499	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
216595010500	Walker A motif; other site
216595010501	ATP binding site [chemical binding]; other site
216595010502	Walker B motif; other site
216595010503	arginine finger; other site
216595010504	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
216595010506	PS00675 Sigma-54 interaction domain ATP-binding region A signature.
216595010507	PS00676 Sigma-54 interaction domain ATP-binding region B signature.
216595010508	PS00688 Sigma-54 interaction domain C-terminal part signature.
216595010509	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
216595010510	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
216595010511	active site
216595010512	dimer interface [polypeptide binding]; other site
216595010513	non-prolyl cis peptide bond; other site
216595010514	insertion regions; other site
216595010516	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
216595010517	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
216595010518	PS00019 Actinin-type actin-binding domain signature 1.
216595010519	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
216595010520	putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027
216595010522	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
216595010523	putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027
216595010524	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
216595010526	Survival protein SurE; Region: SurE; pfam01975
216595010528	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
216595010529	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
216595010530	active site
216595010531	non-prolyl cis peptide bond; other site
216595010533	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
216595010534	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216595010535	N-terminal plug; other site
216595010536	ligand-binding site [chemical binding]; other site
216595010539	PS00430 TonB-dependent receptor proteins signature 1.
216595010540	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
216595010541	putative active site pocket [active]
216595010542	cleavage site
216595010544	StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804
216595010546	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
216595010547	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517
216595010549	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
216595010550	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595010551	dimer interface [polypeptide binding]; other site
216595010552	conserved gate region; other site
216595010553	putative PBP binding loops; other site
216595010554	ABC-ATPase subunit interface; other site
216595010555	6 probable transmembrane helices predicted for PFLU2221 by TMHMM2.0 at aa 7-29, 101-123, 143-165, 185-207, 243-265 and 285-307
216595010557	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595010558	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
216595010559	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595010560	dimer interface [polypeptide binding]; other site
216595010561	conserved gate region; other site
216595010562	putative PBP binding loops; other site
216595010563	ABC-ATPase subunit interface; other site
216595010564	5 probable transmembrane helices predicted for PFLU2222 by TMHMM2.0 at aa 26-48, 95-117, 138-160, 212-234 and 255-277
216595010566	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
216595010567	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
216595010568	Walker A/P-loop; other site
216595010569	ATP binding site [chemical binding]; other site
216595010570	Q-loop/lid; other site
216595010571	ABC transporter signature motif; other site
216595010572	Walker B; other site
216595010573	D-loop; other site
216595010574	H-loop/switch region; other site
216595010575	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
216595010576	Walker A/P-loop; other site
216595010577	ATP binding site [chemical binding]; other site
216595010578	Q-loop/lid; other site
216595010579	ABC transporter signature motif; other site
216595010580	Walker B; other site
216595010581	D-loop; other site
216595010582	H-loop/switch region; other site
216595010583	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
216595010585	PS00017 ATP/GTP-binding site motif A (P-loop).
216595010586	PS00211 ABC transporters family signature.
216595010588	PS00017 ATP/GTP-binding site motif A (P-loop).
216595010589	PS00211 ABC transporters family signature.
216595010590	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
216595010591	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
216595010592	Bacterial type III secretion apparatus protein (OrgA_MxiK); Region: OrgA_MxiK; cl09716
216595010594	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
216595010595	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216595010596	Walker A/P-loop; other site
216595010597	ATP binding site [chemical binding]; other site
216595010598	Q-loop/lid; other site
216595010599	ABC transporter signature motif; other site
216595010600	Walker B; other site
216595010601	D-loop; other site
216595010602	H-loop/switch region; other site
216595010603	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595010604	dimer interface [polypeptide binding]; other site
216595010605	conserved gate region; other site
216595010606	ABC-ATPase subunit interface; other site
216595010608	PS00017 ATP/GTP-binding site motif A (P-loop).
216595010609	PS00211 ABC transporters family signature.
216595010610	9 probable transmembrane helices predicted for PFLU2225 by TMHMM2.0 at aa 379-401, 414-436, 469-491, 496-515, 520-539, 546-568, 594-616, 661-683 and 698-717
216595010612	PS00017 ATP/GTP-binding site motif A (P-loop).
216595010613	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595010614	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
216595010615	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
216595010617	Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040
216595010618	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
216595010620	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595010621	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
216595010623	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595010624	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595010625	The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439
216595010626	putative dimerization interface [polypeptide binding]; other site
216595010629	PS00044 Bacterial regulatory proteins, lysR family signature.
216595010630	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595010631	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
216595010632	substrate binding pocket [chemical binding]; other site
216595010633	membrane-bound complex binding site; other site
216595010634	hinge residues; other site
216595010636	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595010637	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
216595010638	substrate binding pocket [chemical binding]; other site
216595010639	membrane-bound complex binding site; other site
216595010640	hinge residues; other site
216595010641	PS00430 TonB-dependent receptor proteins signature 1.
216595010642	PS00099 Thiolases active site.
216595010644	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
216595010645	FAD binding domain; Region: FAD_binding_4; pfam01565
216595010648	aspartate aminotransferase; Provisional; Region: PRK06107
216595010649	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216595010650	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595010651	homodimer interface [polypeptide binding]; other site
216595010652	catalytic residue [active]
216595010654	PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site.
216595010655	PS00012 Phosphopantetheine attachment site.
216595010656	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595010657	dimer interface [polypeptide binding]; other site
216595010658	conserved gate region; other site
216595010659	putative PBP binding loops; other site
216595010660	ABC-ATPase subunit interface; other site
216595010661	5 probable transmembrane helices predicted for PFLU2234 by TMHMM2.0 at aa 4-26, 39-61, 96-118, 184-203 and 208-230
216595010663	PS00041 Bacterial regulatory proteins, araC family signature.
216595010664	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
216595010665	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595010666	dimer interface [polypeptide binding]; other site
216595010667	conserved gate region; other site
216595010668	putative PBP binding loops; other site
216595010669	ABC-ATPase subunit interface; other site
216595010670	6 probable transmembrane helices predicted for PFLU2235 by TMHMM2.0 at aa 21-43, 58-80, 100-122, 132-154, 193-210 and 225-247
216595010672	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
216595010673	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
216595010674	Walker A/P-loop; other site
216595010675	ATP binding site [chemical binding]; other site
216595010676	Q-loop/lid; other site
216595010677	ABC transporter signature motif; other site
216595010678	Walker B; other site
216595010679	D-loop; other site
216595010680	H-loop/switch region; other site
216595010682	PS00017 ATP/GTP-binding site motif A (P-loop).
216595010683	PS00211 ABC transporters family signature.
216595010684	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
216595010685	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
216595010686	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
216595010687	C-terminal domain interface [polypeptide binding]; other site
216595010688	GSH binding site (G-site) [chemical binding]; other site
216595010689	dimer interface [polypeptide binding]; other site
216595010690	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
216595010691	N-terminal domain interface [polypeptide binding]; other site
216595010692	dimer interface [polypeptide binding]; other site
216595010693	substrate binding pocket (H-site) [chemical binding]; other site
216595010696	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
216595010697	active site residue [active]
216595010698	Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533
216595010699	active site residue [active]
216595010700	Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534
216595010701	active site residue [active]
216595010702	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
216595010703	active site residue [active]
216595010704	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
216595010705	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
216595010706	homodimer interface [polypeptide binding]; other site
216595010707	substrate-cofactor binding pocket; other site
216595010708	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595010709	catalytic residue [active]
216595010712	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595010713	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
216595010714	DNA-binding site [nucleotide binding]; DNA binding site
216595010715	UTRA domain; Region: UTRA; pfam07702
216595010718	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
216595010719	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
216595010720	ligand binding site [chemical binding]; other site
216595010722	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
216595010723	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595010724	active site
216595010725	phosphorylation site [posttranslational modification]
216595010726	intermolecular recognition site; other site
216595010727	dimerization interface [polypeptide binding]; other site
216595010728	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216595010729	DNA binding residues [nucleotide binding]
216595010730	dimerization interface [polypeptide binding]; other site
216595010733	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
216595010734	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595010735	dimer interface [polypeptide binding]; other site
216595010736	phosphorylation site [posttranslational modification]
216595010737	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595010738	ATP binding site [chemical binding]; other site
216595010739	Mg2+ binding site [ion binding]; other site
216595010740	G-X-G motif; other site
216595010741	Response regulator receiver domain; Region: Response_reg; pfam00072
216595010742	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595010743	active site
216595010744	phosphorylation site [posttranslational modification]
216595010745	intermolecular recognition site; other site
216595010746	dimerization interface [polypeptide binding]; other site
216595010750	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595010751	PS00017 ATP/GTP-binding site motif A (P-loop).
216595010752	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595010754	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
216595010755	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595010756	active site
216595010757	phosphorylation site [posttranslational modification]
216595010758	intermolecular recognition site; other site
216595010759	dimerization interface [polypeptide binding]; other site
216595010760	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216595010761	DNA binding residues [nucleotide binding]
216595010762	dimerization interface [polypeptide binding]; other site
216595010764	PS00017 ATP/GTP-binding site motif A (P-loop).
216595010766	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
216595010767	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595010768	dimer interface [polypeptide binding]; other site
216595010769	phosphorylation site [posttranslational modification]
216595010770	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595010771	ATP binding site [chemical binding]; other site
216595010772	Mg2+ binding site [ion binding]; other site
216595010773	G-X-G motif; other site
216595010774	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
216595010775	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595010776	active site
216595010777	phosphorylation site [posttranslational modification]
216595010778	intermolecular recognition site; other site
216595010779	dimerization interface [polypeptide binding]; other site
216595010780	5 probable transmembrane helices predicted for PFLU2249 by TMHMM2.0 at aa 42-64, 69-91, 111-133, 146-168 and 175-192
216595010784	1 probable transmembrane helix predicted for PFLU2250 by TMHMM2.0 at aa 59-81
216595010785	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
216595010786	2 probable transmembrane helices predicted for PFLU2252 by TMHMM2.0 at aa 12-34 and 108-130
216595010787	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595010788	1 probable transmembrane helix predicted for PFLU2253 by TMHMM2.0 at aa 172-194
216595010789	DinB family; Region: DinB; cl17821
216595010790	DinB superfamily; Region: DinB_2; pfam12867
216595010792	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
216595010793	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
216595010794	ligand binding site [chemical binding]; other site
216595010795	flexible hinge region; other site
216595010796	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
216595010797	putative switch regulator; other site
216595010798	non-specific DNA interactions [nucleotide binding]; other site
216595010799	DNA binding site [nucleotide binding]
216595010800	sequence specific DNA binding site [nucleotide binding]; other site
216595010801	putative cAMP binding site [chemical binding]; other site
216595010804	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
216595010805	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
216595010806	NAD binding site [chemical binding]; other site
216595010807	homodimer interface [polypeptide binding]; other site
216595010808	homotetramer interface [polypeptide binding]; other site
216595010809	active site
216595010811	PS00061 Short-chain dehydrogenases/reductases family signature.
216595010812	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
216595010813	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
216595010814	conserved cys residue [active]
216595010818	Protein of unknown function (DUF1349); Region: DUF1349; pfam07081
216595010820	CHASE3 domain; Region: CHASE3; pfam05227
216595010821	HAMP domain; Region: HAMP; pfam00672
216595010822	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
216595010823	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595010824	dimer interface [polypeptide binding]; other site
216595010825	putative CheW interface [polypeptide binding]; other site
216595010829	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
216595010830	nudix motif; other site
216595010832	PS00893 mutT domain signature.
216595010833	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
216595010835	12 probable transmembrane helices predicted for PFLU2264 by TMHMM2.0 at aa 21-38, 42-64, 97-119, 129-148, 160-182, 197-219, 244-266, 291-313, 337-359, 363-385, 405-427 and 431-453
216595010836	PS00639 Eukaryotic thiol (cysteine) proteases histidine active site.
216595010837	PS00218 Amino acid permeases signature.
216595010838	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
216595010839	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
216595010840	conserved cys residue [active]
216595010841	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595010844	PS00041 Bacterial regulatory proteins, araC family signature.
216595010846	Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300
216595010847	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
216595010848	putative ligand binding site [chemical binding]; other site
216595010849	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595010850	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595010851	dimerization interface [polypeptide binding]; other site
216595010852	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595010853	dimer interface [polypeptide binding]; other site
216595010854	phosphorylation site [posttranslational modification]
216595010855	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595010856	ATP binding site [chemical binding]; other site
216595010857	Mg2+ binding site [ion binding]; other site
216595010858	G-X-G motif; other site
216595010859	Response regulator receiver domain; Region: Response_reg; pfam00072
216595010860	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595010861	active site
216595010862	phosphorylation site [posttranslational modification]
216595010863	intermolecular recognition site; other site
216595010864	dimerization interface [polypeptide binding]; other site
216595010865	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
216595010866	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595010867	ATP binding site [chemical binding]; other site
216595010868	Mg2+ binding site [ion binding]; other site
216595010869	G-X-G motif; other site
216595010870	1 probable transmembrane helix predicted for PFLU2267 by TMHMM2.0 at aa 12-34
216595010876	N-terminal catalytic domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_N; cd10320
216595010877	active site
216595010878	catalytic site [active]
216595010879	Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316
216595010880	C-terminal domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_C; cd10317
216595010881	Ca binding site [ion binding]; other site
216595010882	substrate binding site [chemical binding]; other site
216595010884	Pectate lyase; Region: Pec_lyase_C; cl01593
216595010886	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
216595010887	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
216595010888	Cytochrome c; Region: Cytochrom_C; pfam00034
216595010890	PS00190 Cytochrome c family heme-binding site signature.
216595010891	PS00190 Cytochrome c family heme-binding site signature.
216595010892	PS00190 Cytochrome c family heme-binding site signature.
216595010893	1 probable transmembrane helix predicted for PFLU2270 by TMHMM2.0 at aa 7-29
216595010894	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
216595010895	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
216595010896	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
216595010897	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
216595010898	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
216595010901	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
216595010902	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
216595010903	catalytic loop [active]
216595010904	iron binding site [ion binding]; other site
216595010905	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
216595010908	PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature.
216595010909	Transcriptional regulators [Transcription]; Region: FadR; COG2186
216595010910	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595010911	DNA-binding site [nucleotide binding]; DNA binding site
216595010912	FCD domain; Region: FCD; pfam07729
216595010915	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216595010916	NADH(P)-binding; Region: NAD_binding_10; pfam13460
216595010917	NAD(P) binding site [chemical binding]; other site
216595010918	active site
216595010920	Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629
216595010922	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
216595010923	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 4. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_4; cd03329
216595010924	putative active site pocket [active]
216595010925	metal binding site [ion binding]; metal-binding site
216595010928	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
216595010929	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
216595010931	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
216595010932	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595010933	dimer interface [polypeptide binding]; other site
216595010934	conserved gate region; other site
216595010935	putative PBP binding loops; other site
216595010936	ABC-ATPase subunit interface; other site
216595010937	6 probable transmembrane helices predicted for PFLU2279 by TMHMM2.0 at aa 29-51, 113-135, 156-178, 218-237, 276-298 and 318-340
216595010939	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
216595010940	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
216595010942	D-ala-D-ala transporter subunit; Provisional; Region: PRK09881
216595010943	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595010944	dimer interface [polypeptide binding]; other site
216595010945	conserved gate region; other site
216595010946	ABC-ATPase subunit interface; other site
216595010947	5 probable transmembrane helices predicted for PFLU2281 by TMHMM2.0 at aa 45-67, 112-134, 141-163, 228-250 and 271-293
216595010949	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
216595010950	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
216595010951	Walker A/P-loop; other site
216595010952	ATP binding site [chemical binding]; other site
216595010953	Q-loop/lid; other site
216595010954	ABC transporter signature motif; other site
216595010955	Walker B; other site
216595010956	D-loop; other site
216595010957	H-loop/switch region; other site
216595010958	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
216595010960	PS00017 ATP/GTP-binding site motif A (P-loop).
216595010961	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
216595010962	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
216595010963	Walker A/P-loop; other site
216595010964	ATP binding site [chemical binding]; other site
216595010965	Q-loop/lid; other site
216595010966	ABC transporter signature motif; other site
216595010967	Walker B; other site
216595010968	D-loop; other site
216595010969	H-loop/switch region; other site
216595010971	PS00017 ATP/GTP-binding site motif A (P-loop).
216595010972	PS00211 ABC transporters family signature.
216595010973	5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
216595010974	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
216595010975	putative active site [active]
216595010976	catalytic residue [active]
216595010978	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
216595010979	putative substrate binding pocket [chemical binding]; other site
216595010980	trimer interface [polypeptide binding]; other site
216595010981	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
216595010982	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
216595010983	Interdomain contacts; other site
216595010984	Cytokine receptor motif; other site
216595010985	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
216595010988	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
216595010989	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595010990	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447
216595010991	putative dimerization interface [polypeptide binding]; other site
216595010992	putative substrate binding pocket [chemical binding]; other site
216595010995	PS00044 Bacterial regulatory proteins, lysR family signature.
216595010996	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595010997	D-galactonate transporter; Region: 2A0114; TIGR00893
216595010998	putative substrate translocation pore; other site
216595010999	12 probable transmembrane helices predicted for PFLU2288 by TMHMM2.0 at aa 25-47, 62-84, 91-110, 116-138, 151-173, 183-205, 253-275, 290-312, 319-338, 342-364, 377-399 and 409-426
216595011001	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
216595011002	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
216595011003	active site
216595011004	tetramer interface [polypeptide binding]; other site
216595011007	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
216595011008	Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_1; cd05974
216595011009	active site
216595011010	acyl-activating enzyme (AAE) consensus motif; other site
216595011011	putative CoA binding site [chemical binding]; other site
216595011012	AMP binding site [chemical binding]; other site
216595011014	PS00455 Putative AMP-binding domain signature.
216595011015	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595011016	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595011017	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
216595011018	putative effector binding pocket; other site
216595011019	dimerization interface [polypeptide binding]; other site
216595011022	PS00044 Bacterial regulatory proteins, lysR family signature.
216595011023	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
216595011024	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
216595011025	tetrameric interface [polypeptide binding]; other site
216595011026	NAD binding site [chemical binding]; other site
216595011027	catalytic residues [active]
216595011029	PS00070 Aldehyde dehydrogenases cysteine active site.
216595011030	Pectate lyase; Region: Pec_lyase_C; pfam00544
216595011032	Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997
216595011033	active site
216595011035	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
216595011036	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595011037	dimerization interface [polypeptide binding]; other site
216595011038	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595011039	dimer interface [polypeptide binding]; other site
216595011040	putative CheW interface [polypeptide binding]; other site
216595011041	2 probable transmembrane helices predicted for PFLU2295 by TMHMM2.0 at aa 4-26 and 310-332
216595011044	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
216595011045	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
216595011046	putative ligand binding site [chemical binding]; other site
216595011048	Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism]; Region: AraH; COG1172
216595011049	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
216595011050	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
216595011051	TM-ABC transporter signature motif; other site
216595011053	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
216595011054	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
216595011055	Walker A/P-loop; other site
216595011056	ATP binding site [chemical binding]; other site
216595011057	Q-loop/lid; other site
216595011058	ABC transporter signature motif; other site
216595011059	Walker B; other site
216595011060	D-loop; other site
216595011061	H-loop/switch region; other site
216595011062	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
216595011064	PS00211 ABC transporters family signature.
216595011066	PS00017 ATP/GTP-binding site motif A (P-loop).
216595011067	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
216595011068	D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634
216595011069	putative ligand binding site [chemical binding]; other site
216595011071	xylose isomerase; Provisional; Region: PRK05474
216595011072	xylose isomerase; Region: xylose_isom_A; TIGR02630
216595011073	PS00225 Crystallins beta and gamma 'Greek key' motif signature.
216595011075	PS00172 Xylose isomerase signature 1.
216595011076	PS00173 Xylose isomerase signature 2.
216595011077	Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543
216595011078	putative dimerization interface [polypeptide binding]; other site
216595011079	Transcriptional regulators [Transcription]; Region: PurR; COG1609
216595011080	putative ligand binding site [chemical binding]; other site
216595011081	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
216595011082	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595011084	PS00041 Bacterial regulatory proteins, araC family signature.
216595011086	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
216595011088	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
216595011089	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
216595011090	Trp docking motif [polypeptide binding]; other site
216595011091	putative active site [active]
216595011096	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
216595011097	Transcriptional regulator [Transcription]; Region: IclR; COG1414
216595011099	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595011100	putative substrate translocation pore; other site
216595011102	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
216595011103	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
216595011104	ligand binding site [chemical binding]; other site
216595011105	NAD binding site [chemical binding]; other site
216595011106	dimerization interface [polypeptide binding]; other site
216595011107	catalytic site [active]
216595011110	PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2.
216595011111	PS00017 ATP/GTP-binding site motif A (P-loop).
216595011112	hypothetical protein; Validated; Region: PRK06201
216595011113	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
216595011115	Transmembrane secretion effector; Region: MFS_3; pfam05977
216595011117	9 probable transmembrane helices predicted for PFLU2309 by TMHMM2.0 at aa 53-75, 87-109, 175-197, 231-253, 263-285, 292-314, 318-340, 353-375 and 380-402
216595011118	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
216595011119	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
216595011121	1 probable transmembrane helix predicted for PFLU2311 by TMHMM2.0 at aa 7-29
216595011122	PS00017 ATP/GTP-binding site motif A (P-loop).
216595011124	PS00430 TonB-dependent receptor proteins signature 1.
216595011125	1 probable transmembrane helix predicted for PFLU2312 by TMHMM2.0 at aa 127-149
216595011128	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
216595011130	PS00501 Signal peptidases I serine active site.
216595011131	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
216595011132	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
216595011133	Na binding site [ion binding]; other site
216595011135	12 probable transmembrane helices predicted for PFLU2315 by TMHMM2.0 at aa 32-54, 59-81, 102-124, 139-161, 168-185, 200-217, 238-260, 283-305, 326-348, 352-371, 392-414 and 434-451
216595011136	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
216595011137	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
216595011138	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
216595011139	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
216595011143	Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267
216595011145	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
216595011146	hydroxyglutarate oxidase; Provisional; Region: PRK11728
216595011148	PS00017 ATP/GTP-binding site motif A (P-loop).
216595011149	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14194
216595011150	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
216595011151	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
216595011152	homodimer interface [polypeptide binding]; other site
216595011153	NADP binding site [chemical binding]; other site
216595011154	substrate binding site [chemical binding]; other site
216595011156	PS00767 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2.
216595011158	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
216595011159	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
216595011160	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
216595011161	putative active site [active]
216595011162	putative substrate binding site [chemical binding]; other site
216595011163	putative cosubstrate binding site; other site
216595011164	catalytic site [active]
216595011166	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
216595011167	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216595011168	non-specific DNA binding site [nucleotide binding]; other site
216595011169	salt bridge; other site
216595011170	sequence-specific DNA binding site [nucleotide binding]; other site
216595011171	Cupin domain; Region: Cupin_2; pfam07883
216595011174	glutamine synthetase, type III; Region: gln_synth_III; TIGR03105
216595011175	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
216595011177	Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067
216595011178	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
216595011179	Glutamine amidotransferases class-II (Gn-AT)_GlxB-type.  GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907
216595011180	putative active site [active]
216595011181	PS00443 Glutamine amidotransferases class-II active site.
216595011183	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504
216595011184	domain_subunit interface; other site
216595011186	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
216595011187	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
216595011188	active site
216595011189	FMN binding site [chemical binding]; other site
216595011190	substrate binding site [chemical binding]; other site
216595011191	3Fe-4S cluster binding site [ion binding]; other site
216595011193	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
216595011194	12 probable transmembrane helices predicted for PFLU2327 by TMHMM2.0 at aa 7-26, 41-63, 70-92, 137-156, 163-185, 200-222, 235-254, 264-286, 298-320, 324-341, 353-374 and 389-411
216595011196	PS01219 Ammonium transporters signature.
216595011197	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14194
216595011198	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
216595011199	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
216595011200	homodimer interface [polypeptide binding]; other site
216595011201	NADP binding site [chemical binding]; other site
216595011202	substrate binding site [chemical binding]; other site
216595011204	PS00767 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2.
216595011206	PS00766 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 1.
216595011207	Amino acid permease; Region: AA_permease_2; pfam13520
216595011209	Domain of unknown function (DUF1989); Region: DUF1989; cl01474
216595011210	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
216595011211	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
216595011212	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
216595011213	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
216595011216	PS00225 Crystallins beta and gamma 'Greek key' motif signature.
216595011217	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
216595011218	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
216595011220	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
216595011221	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
216595011222	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
216595011223	putative active site [active]
216595011224	putative substrate binding site [chemical binding]; other site
216595011225	putative cosubstrate binding site; other site
216595011226	catalytic site [active]
216595011228	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595011229	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
216595011230	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
216595011234	PS00017 ATP/GTP-binding site motif A (P-loop).
216595011235	Protein of unknown function (DUF3445); Region: DUF3445; pfam11927
216595011236	PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1.
216595011237	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
216595011238	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
216595011239	FMN-binding pocket [chemical binding]; other site
216595011240	flavin binding motif; other site
216595011241	phosphate binding motif [ion binding]; other site
216595011242	beta-alpha-beta structure motif; other site
216595011243	NAD binding pocket [chemical binding]; other site
216595011244	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
216595011245	catalytic loop [active]
216595011246	iron binding site [ion binding]; other site
216595011248	PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature.
216595011251	PS00190 Cytochrome c family heme-binding site signature.
216595011252	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
216595011253	Histidine kinase; Region: HisKA_3; pfam07730
216595011254	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595011255	ATP binding site [chemical binding]; other site
216595011256	Mg2+ binding site [ion binding]; other site
216595011257	G-X-G motif; other site
216595011259	transcriptional regulator NarL; Provisional; Region: PRK10651
216595011260	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595011261	active site
216595011262	phosphorylation site [posttranslational modification]
216595011263	intermolecular recognition site; other site
216595011264	dimerization interface [polypeptide binding]; other site
216595011265	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216595011266	DNA binding residues [nucleotide binding]
216595011267	dimerization interface [polypeptide binding]; other site
216595011270	PS00622 Bacterial regulatory proteins, luxR family signature.
216595011271	PAS fold; Region: PAS_4; pfam08448
216595011272	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595011273	putative active site [active]
216595011274	heme pocket [chemical binding]; other site
216595011275	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595011276	PAS fold; Region: PAS_3; pfam08447
216595011277	putative active site [active]
216595011278	heme pocket [chemical binding]; other site
216595011280	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
216595011281	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216595011282	Walker A/P-loop; other site
216595011283	ATP binding site [chemical binding]; other site
216595011284	Q-loop/lid; other site
216595011285	ABC transporter signature motif; other site
216595011286	Walker B; other site
216595011287	D-loop; other site
216595011288	H-loop/switch region; other site
216595011289	TOBE domain; Region: TOBE_2; pfam08402
216595011292	PS00211 ABC transporters family signature.
216595011293	PS00017 ATP/GTP-binding site motif A (P-loop).
216595011294	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
216595011295	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595011296	dimer interface [polypeptide binding]; other site
216595011297	conserved gate region; other site
216595011298	putative PBP binding loops; other site
216595011299	ABC-ATPase subunit interface; other site
216595011301	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
216595011302	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595011303	dimer interface [polypeptide binding]; other site
216595011304	conserved gate region; other site
216595011305	putative PBP binding loops; other site
216595011306	ABC-ATPase subunit interface; other site
216595011308	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595011309	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
216595011310	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
216595011312	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK12485
216595011313	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
216595011314	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
216595011315	dimerization interface [polypeptide binding]; other site
216595011316	active site
216595011319	Uncharacterized conserved protein [Function unknown]; Region: COG5470
216595011321	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
216595011322	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
216595011323	nudix motif; other site
216595011325	PS00893 mutT domain signature.
216595011326	Transcriptional regulators [Transcription]; Region: GntR; COG1802
216595011327	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595011328	DNA-binding site [nucleotide binding]; DNA binding site
216595011329	FCD domain; Region: FCD; pfam07729
216595011332	PS00043 Bacterial regulatory proteins, gntR family signature.
216595011333	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
216595011335	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
216595011336	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
216595011337	NAD(P) binding site [chemical binding]; other site
216595011338	catalytic residues [active]
216595011340	PS00687 Aldehyde dehydrogenases glutamic acid active site.
216595011341	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
216595011342	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
216595011344	Amino acid synthesis; Region: AA_synth; pfam06684
216595011346	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
216595011347	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
216595011349	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
216595011351	putative aldolase; Validated; Region: PRK08130
216595011352	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
216595011353	intersubunit interface [polypeptide binding]; other site
216595011354	active site
216595011355	Zn2+ binding site [ion binding]; other site
216595011357	fructuronate transporter; Provisional; Region: PRK10034; cl15264
216595011358	fructuronate transporter; Provisional; Region: PRK10034; cl15264
216595011359	12 probable transmembrane helices predicted for PFLU2355 by TMHMM2.0 at aa 12-34, 38-57, 74-96, 116-138, 151-170, 190-209, 276-298, 313-335, 348-370, 385-407, 438-460 and 475-497
216595011361	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
216595011363	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
216595011364	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
216595011365	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
216595011368	PS00894 Bacterial regulatory proteins, deoR family signature.
216595011369	Cache domain; Region: Cache_1; pfam02743
216595011370	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595011371	dimerization interface [polypeptide binding]; other site
216595011372	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
216595011373	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595011374	dimer interface [polypeptide binding]; other site
216595011375	putative CheW interface [polypeptide binding]; other site
216595011379	PS00017 ATP/GTP-binding site motif A (P-loop).
216595011380	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
216595011382	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
216595011383	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216595011384	metal binding site [ion binding]; metal-binding site
216595011385	active site
216595011386	I-site; other site
216595011387	PS00294 Prenyl group binding site (CAAX box).
216595011388	6 probable transmembrane helices predicted for PFLU2361 by TMHMM2.0 at aa 13-35, 40-59, 66-88, 93-115, 120-139 and 143-165
216595011390	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
216595011391	active site
216595011392	metal binding site [ion binding]; metal-binding site
216595011393	homotetramer interface [polypeptide binding]; other site
216595011395	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
216595011396	dimerization interface [polypeptide binding]; other site
216595011397	putative DNA binding site [nucleotide binding]; other site
216595011398	putative Zn2+ binding site [ion binding]; other site
216595011400	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
216595011401	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
216595011402	active site
216595011403	FMN binding site [chemical binding]; other site
216595011404	substrate binding site [chemical binding]; other site
216595011405	homotetramer interface [polypeptide binding]; other site
216595011406	catalytic residue [active]
216595011408	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
216595011409	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216595011410	N-terminal plug; other site
216595011411	ligand-binding site [chemical binding]; other site
216595011414	Transcriptional regulators [Transcription]; Region: FadR; COG2186
216595011415	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595011416	DNA-binding site [nucleotide binding]; DNA binding site
216595011417	FCD domain; Region: FCD; pfam07729
216595011420	dihydroxy-acid dehydratase; Validated; Region: PRK06131
216595011422	PS00017 ATP/GTP-binding site motif A (P-loop).
216595011423	PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1.
216595011424	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595011425	D-galactonate transporter; Region: 2A0114; TIGR00893
216595011426	putative substrate translocation pore; other site
216595011427	12 probable transmembrane helices predicted for PFLU2368 by TMHMM2.0 at aa 35-52, 67-89, 105-124, 129-151, 163-182, 197-219, 265-287, 297-319, 332-349, 354-376, 389-411 and 421-443
216595011429	Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802
216595011430	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
216595011432	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
216595011433	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
216595011434	dimer interface [polypeptide binding]; other site
216595011435	NADP binding site [chemical binding]; other site
216595011436	catalytic residues [active]
216595011438	PS00070 Aldehyde dehydrogenases cysteine active site.
216595011439	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
216595011441	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
216595011442	Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540
216595011443	ligand binding site [chemical binding]; other site
216595011444	1 probable transmembrane helix predicted for PFLU2372 by TMHMM2.0 at aa 7-29
216595011446	L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288
216595011447	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
216595011448	Walker A/P-loop; other site
216595011449	ATP binding site [chemical binding]; other site
216595011450	Q-loop/lid; other site
216595011451	ABC transporter signature motif; other site
216595011452	Walker B; other site
216595011453	D-loop; other site
216595011454	H-loop/switch region; other site
216595011455	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
216595011457	PS00017 ATP/GTP-binding site motif A (P-loop).
216595011458	PS00211 ABC transporters family signature.
216595011460	PS00211 ABC transporters family signature.
216595011461	PS00213 Lipocalin signature.
216595011462	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
216595011463	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
216595011464	TM-ABC transporter signature motif; other site
216595011465	10 probable transmembrane helices predicted for PFLU2374 by TMHMM2.0 at aa 20-42, 52-71, 78-95, 101-123, 128-150, 170-192, 221-243, 248-270, 277-294 and 299-316
216595011467	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
216595011468	active site
216595011469	catalytic residues [active]
216595011471	PS00545 Aldose 1-epimerase putative active site.
216595011472	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
216595011473	classical (c) SDRs; Region: SDR_c; cd05233
216595011474	NAD(P) binding site [chemical binding]; other site
216595011475	active site
216595011477	PS00061 Short-chain dehydrogenases/reductases family signature.
216595011478	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
216595011479	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
216595011480	C-terminal domain interface [polypeptide binding]; other site
216595011481	GSH binding site (G-site) [chemical binding]; other site
216595011482	dimer interface [polypeptide binding]; other site
216595011483	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
216595011484	dimer interface [polypeptide binding]; other site
216595011485	N-terminal domain interface [polypeptide binding]; other site
216595011486	putative substrate binding pocket (H-site) [chemical binding]; other site
216595011488	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
216595011489	active site
216595011490	SUMO-1 interface [polypeptide binding]; other site
216595011492	Cupin; Region: Cupin_6; pfam12852
216595011493	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595011494	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
216595011495	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595011497	PS00041 Bacterial regulatory proteins, araC family signature.
216595011499	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595011500	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
216595011501	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
216595011502	12 probable transmembrane helices predicted for PFLU2381 by TMHMM2.0 at aa 21-43, 58-80, 92-114, 119-141, 148-170, 180-199, 220-242, 257-279, 286-308, 312-334, 347-369 and 374-396
216595011504	putative S-transferase; Provisional; Region: PRK11752
216595011505	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
216595011506	C-terminal domain interface [polypeptide binding]; other site
216595011507	GSH binding site (G-site) [chemical binding]; other site
216595011508	dimer interface [polypeptide binding]; other site
216595011509	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
216595011510	dimer interface [polypeptide binding]; other site
216595011511	N-terminal domain interface [polypeptide binding]; other site
216595011512	active site
216595011515	PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.
216595011516	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
216595011517	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
216595011518	putative ligand binding site [chemical binding]; other site
216595011520	PS00017 ATP/GTP-binding site motif A (P-loop).
216595011521	1 probable transmembrane helix predicted for PFLU2383 by TMHMM2.0 at aa 5-27
216595011522	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
216595011524	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
216595011525	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
216595011526	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
216595011529	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
216595011530	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595011531	Walker A motif; other site
216595011532	ATP binding site [chemical binding]; other site
216595011533	Walker B motif; other site
216595011534	arginine finger; other site
216595011535	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
216595011538	PS00676 Sigma-54 interaction domain ATP-binding region B signature.
216595011539	PS00688 Sigma-54 interaction domain C-terminal part signature.
216595011541	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
216595011542	DNA binding site [nucleotide binding]
216595011543	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
216595011544	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
216595011545	putative ligand binding site [chemical binding]; other site
216595011546	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
216595011547	This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511
216595011548	putative di-iron ligands [ion binding]; other site
216595011549	3 probable transmembrane helices predicted for PFLU2390 by TMHMM2.0 at aa 58-77, 81-98 and 217-239
216595011551	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
216595011552	[2Fe-2S] cluster binding site [ion binding]; other site
216595011554	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
216595011555	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
216595011558	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
216595011560	Bacitracin resistance protein BacA; Region: BacA; pfam02673
216595011562	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216595011563	Coenzyme A binding pocket [chemical binding]; other site
216595011564	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
216595011565	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
216595011566	conserved cys residue [active]
216595011567	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595011569	PS00041 Bacterial regulatory proteins, araC family signature.
216595011571	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
216595011572	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216595011574	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
216595011575	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
216595011576	potential catalytic triad [active]
216595011577	conserved cys residue [active]
216595011579	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
216595011580	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
216595011581	FMN binding site [chemical binding]; other site
216595011582	active site
216595011583	substrate binding site [chemical binding]; other site
216595011584	catalytic residue [active]
216595011586	Transposase; Region: HTH_Tnp_1; pfam01527
216595011587	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
216595011589	Integrase core domain; Region: rve; pfam00665
216595011590	Integrase core domain; Region: rve_3; pfam13683
216595011592	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
216595011593	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
216595011594	NAD(P) binding site [chemical binding]; other site
216595011597	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595011598	Major Facilitator Superfamily; Region: MFS_1; pfam07690
216595011599	putative substrate translocation pore; other site
216595011601	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595011602	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595011603	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
216595011604	dimerization interface [polypeptide binding]; other site
216595011607	Predicted membrane protein [Function unknown]; Region: COG2259
216595011608	4 probable transmembrane helices predicted for PFLU2406 by TMHMM2.0 at aa 24-43, 63-85, 90-107 and 117-139
216595011610	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
216595011611	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
216595011612	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
216595011614	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
216595011615	1 probable transmembrane helix predicted for PFLU2409 by TMHMM2.0 at aa 12-34
216595011616	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
216595011617	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
216595011618	putative NAD(P) binding site [chemical binding]; other site
216595011619	putative substrate binding site [chemical binding]; other site
216595011620	catalytic Zn binding site [ion binding]; other site
216595011621	structural Zn binding site [ion binding]; other site
216595011622	dimer interface [polypeptide binding]; other site
216595011624	PS00190 Cytochrome c family heme-binding site signature.
216595011625	PS00059 Zinc-containing alcohol dehydrogenases signature.
216595011627	PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature.
216595011628	Secretin and TonB N terminus short domain; Region: STN; smart00965
216595011629	TonB C terminal; Region: TonB_2; pfam13103
216595011630	1 probable transmembrane helix predicted for PFLU2412 by TMHMM2.0 at aa 12-34
216595011632	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
216595011634	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
216595011635	FecR protein; Region: FecR; pfam04773
216595011637	type II secretion system secreton cluster 1
216595011638	Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795
216595011639	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
216595011640	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
216595011642	1 probable transmembrane helix predicted for PFLU2415 by TMHMM2.0 at aa 7-29
216595011643	PS00409 Prokaryotic N-terminal methylation site.
216595011644	type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708
216595011645	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
216595011646	Type II transport protein GspH; Region: GspH; pfam12019
216595011647	1 probable transmembrane helix predicted for PFLU2416 by TMHMM2.0 at aa 49-71
216595011649	PS00409 Prokaryotic N-terminal methylation site.
216595011650	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
216595011651	1 probable transmembrane helix predicted for PFLU2417 by TMHMM2.0 at aa 7-29
216595011652	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
216595011654	1 probable transmembrane helix predicted for PFLU2418 by TMHMM2.0 at aa 12-34
216595011656	PS00409 Prokaryotic N-terminal methylation site.
216595011657	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
216595011658	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
216595011659	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
216595011661	PS00409 Prokaryotic N-terminal methylation site.
216595011662	1 probable transmembrane helix predicted for PFLU2419 by TMHMM2.0 at aa 20-42
216595011664	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
216595011666	1 probable transmembrane helix predicted for PFLU2420 by TMHMM2.0 at aa 13-35
216595011667	type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709
216595011668	GspL periplasmic domain; Region: GspL_C; cl14909
216595011670	Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612
216595011672	1 probable transmembrane helix predicted for PFLU2422 by TMHMM2.0 at aa 39-61
216595011673	type II secretion system protein D; Region: type_II_gspD; TIGR02517
216595011674	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
216595011675	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
216595011676	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
216595011677	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
216595011678	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595011683	type II secretion system protein E; Region: type_II_gspE; TIGR02533
216595011684	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
216595011685	Walker A motif; other site
216595011686	ATP binding site [chemical binding]; other site
216595011687	Walker B motif; other site
216595011689	PS00017 ATP/GTP-binding site motif A (P-loop).
216595011690	PS00662 Bacterial type II secretion system protein E signature.
216595011691	type II secretion system protein F; Region: GspF; TIGR02120
216595011692	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
216595011693	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
216595011695	3 probable transmembrane helices predicted for PFLU2425 by TMHMM2.0 at aa 168-190, 219-241 and 374-396
216595011697	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
216595011698	haemagglutination activity domain; Region: Haemagg_act; smart00912
216595011699	Filamentous haemagglutinin family outer membrane protein; Region: DUF3739; pfam12545
216595011701	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
216595011702	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
216595011703	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
216595011704	Surface antigen; Region: Bac_surface_Ag; pfam01103
216595011707	Domain of unknown function (DUF2341); Region: DUF2341; pfam10102
216595011708	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
216595011709	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
216595011710	4 probable transmembrane helices predicted for PFLU2434 by TMHMM2.0 at aa 5-24, 365-387, 491-513 and 528-550
216595011713	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
216595011714	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
216595011716	1 probable transmembrane helix predicted for PFLU2435 by TMHMM2.0 at aa 15-37
216595011717	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
216595011718	1 probable transmembrane helix predicted for PFLU2436 by TMHMM2.0 at aa 21-38
216595011719	PS00116 DNA polymerase family B signature.
216595011720	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
216595011721	nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933
216595011722	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
216595011724	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595011725	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595011726	LysR substrate binding domain; Region: LysR_substrate; pfam03466
216595011728	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595011729	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
216595011730	dimerization interface [polypeptide binding]; other site
216595011733	PS00044 Bacterial regulatory proteins, lysR family signature.
216595011734	Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406
216595011735	catalytic core [active]
216595011737	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
216595011738	active site
216595011739	SAM binding site [chemical binding]; other site
216595011740	homodimer interface [polypeptide binding]; other site
216595011742	putative hydrolase; Provisional; Region: PRK11460
216595011743	Predicted esterase [General function prediction only]; Region: COG0400
216595011745	hypothetical protein; Provisional; Region: PRK11615
216595011746	PS00017 ATP/GTP-binding site motif A (P-loop).
216595011747	1 probable transmembrane helix predicted for PFLU2447 by TMHMM2.0 at aa 7-24
216595011748	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
216595011749	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
216595011750	TrkA-N domain; Region: TrkA_N; pfam02254
216595011753	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
216595011754	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
216595011756	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
216595011757	EamA-like transporter family; Region: EamA; pfam00892
216595011760	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
216595011761	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
216595011762	active site
216595011763	dimer interface [polypeptide binding]; other site
216595011764	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
216595011765	Ligand Binding Site [chemical binding]; other site
216595011766	Molecular Tunnel; other site
216595011769	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
216595011770	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
216595011771	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
216595011772	substrate binding site [chemical binding]; other site
216595011773	oxyanion hole (OAH) forming residues; other site
216595011774	trimer interface [polypeptide binding]; other site
216595011776	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
216595011777	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595011778	Helix-turn-helix domain; Region: HTH_18; pfam12833
216595011779	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595011782	PS00041 Bacterial regulatory proteins, araC family signature.
216595011784	Protein of unknown function (DUF726); Region: DUF726; pfam05277
216595011785	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735
216595011786	PS00120 Lipases, serine active site.
216595011788	1 probable transmembrane helix predicted for PFLU2456 by TMHMM2.0 at aa 472-494
216595011789	manganese transport protein MntH; Reviewed; Region: PRK00701
216595011790	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
216595011791	11 probable transmembrane helices predicted for PFLU2457 by TMHMM2.0 at aa 30-49, 64-86, 114-136, 140-162, 169-191, 211-233, 261-283, 298-320, 352-369, 379-397 and 417-434
216595011793	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
216595011794	putative active site [active]
216595011796	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
216595011798	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595011799	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595011800	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
216595011801	putative effector binding pocket; other site
216595011802	dimerization interface [polypeptide binding]; other site
216595011805	PS00044 Bacterial regulatory proteins, lysR family signature.
216595011806	Protein of unknown function, DUF606; Region: DUF606; pfam04657
216595011807	5 probable transmembrane helices predicted for PFLU2461 by TMHMM2.0 at aa 19-41, 51-73, 86-108, 112-134 and 141-160
216595011809	Protein of unknown function, DUF606; Region: DUF606; pfam04657
216595011810	4 probable transmembrane helices predicted for PFLU2462 by TMHMM2.0 at aa 7-29, 39-61, 81-112 and 127-149
216595011812	Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069
216595011814	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
216595011815	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
216595011816	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595011818	PS00041 Bacterial regulatory proteins, araC family signature.
216595011820	Protein of unknown function (DUF1427); Region: DUF1427; pfam07235
216595011822	2 probable transmembrane helices predicted for PFLU2468 by TMHMM2.0 at aa 3-20 and 24-41
216595011823	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
216595011824	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
216595011825	putative NAD(P) binding site [chemical binding]; other site
216595011828	Purine nucleoside permease (NUP); Region: NUP; pfam06516
216595011830	1 probable transmembrane helix predicted for PFLU2470 by TMHMM2.0 at aa 9-31
216595011831	nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106
216595011833	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
216595011834	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
216595011835	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595011837	PS00041 Bacterial regulatory proteins, araC family signature.
216595011838	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
216595011839	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
216595011841	sorbitol dehydrogenase; Provisional; Region: PRK07067
216595011842	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216595011843	NAD(P) binding site [chemical binding]; other site
216595011844	active site
216595011846	PS00061 Short-chain dehydrogenases/reductases family signature.
216595011847	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
216595011848	nudix motif; other site
216595011849	PFI-6
216595011850	phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259
216595011851	NmrA-like family; Region: NmrA; pfam05368
216595011852	NAD(P) binding site [chemical binding]; other site
216595011853	active site lysine
216595011855	Predicted transcriptional regulators [Transcription]; Region: COG1733
216595011856	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
216595011858	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
216595011859	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
216595011860	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
216595011861	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
216595011862	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
216595011865	Nitrate and nitrite sensing; Region: NIT; pfam08376
216595011866	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
216595011867	HAMP domain; Region: HAMP; pfam00672
216595011868	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595011869	dimer interface [polypeptide binding]; other site
216595011870	putative CheW interface [polypeptide binding]; other site
216595011871	2 probable transmembrane helices predicted for PFLU2486 by TMHMM2.0 at aa 25-44 and 314-336
216595011875	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
216595011876	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
216595011877	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
216595011878	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
216595011879	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
216595011880	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
216595011881	DNA binding site [nucleotide binding]
216595011882	active site
216595011884	PS00374 Methylated-DNA--protein-cysteine methyltransferase active site.
216595011886	PS00041 Bacterial regulatory proteins, araC family signature.
216595011888	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
216595011889	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
216595011890	tetramer interface [polypeptide binding]; other site
216595011891	active site
216595011892	Mg2+/Mn2+ binding site [ion binding]; other site
216595011893	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
216595011894	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
216595011895	putative ion selectivity filter; other site
216595011896	putative pore gating glutamate residue; other site
216595011897	putative H+/Cl- coupling transport residue; other site
216595011899	PS00044 Bacterial regulatory proteins, lysR family signature.
216595011900	PS00216 Sugar transport proteins signature 1.
216595011902	1 probable transmembrane helix predicted for PFLU2491 by TMHMM2.0 at aa 15-34
216595011904	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
216595011905	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
216595011906	conserved cys residue [active]
216595011907	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595011908	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595011912	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
216595011913	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595011914	dimerization interface [polypeptide binding]; other site
216595011915	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
216595011916	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595011917	dimer interface [polypeptide binding]; other site
216595011918	putative CheW interface [polypeptide binding]; other site
216595011919	2 probable transmembrane helices predicted for PFLU2496 by TMHMM2.0 at aa 10-32 and 190-212
216595011922	Helix-turn-helix domain; Region: HTH_18; pfam12833
216595011923	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595011924	PAS domain; Region: PAS_9; pfam13426
216595011925	putative active site [active]
216595011926	heme pocket [chemical binding]; other site
216595011927	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595011928	PAS domain; Region: PAS_9; pfam13426
216595011929	putative active site [active]
216595011930	heme pocket [chemical binding]; other site
216595011931	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
216595011932	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595011933	dimer interface [polypeptide binding]; other site
216595011934	putative CheW interface [polypeptide binding]; other site
216595011938	Fusaric acid resistance protein family; Region: FUSC; pfam04632
216595011941	PS00287 Cysteine proteases inhibitors signature.
216595011942	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
216595011943	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
216595011944	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
216595011945	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
216595011946	conserved cys residue [active]
216595011949	PS00041 Bacterial regulatory proteins, araC family signature.
216595011951	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
216595011952	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
216595011953	conserved cys residue [active]
216595011954	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595011956	PS00041 Bacterial regulatory proteins, araC family signature.
216595011959	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
216595011960	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216595011961	N-terminal plug; other site
216595011962	ligand-binding site [chemical binding]; other site
216595011964	PS01156 TonB-dependent receptor proteins signature 2.
216595011966	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
216595011967	Transposase; Region: HTH_Tnp_1; cl17663
216595011968	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
216595011970	IS2 transposase TnpB; Reviewed; Region: PRK09409
216595011971	HTH-like domain; Region: HTH_21; pfam13276
216595011972	Integrase core domain; Region: rve; pfam00665
216595011973	Integrase core domain; Region: rve_3; pfam13683
216595011975	GAF domain; Region: GAF; pfam01590
216595011976	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
216595011977	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595011978	dimer interface [polypeptide binding]; other site
216595011979	phosphorylation site [posttranslational modification]
216595011980	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595011981	ATP binding site [chemical binding]; other site
216595011982	G-X-G motif; other site
216595011986	transcriptional regulator BetI; Validated; Region: PRK00767
216595011987	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
216595011988	active site
216595011989	catalytic residues [active]
216595011990	DNA binding site [nucleotide binding]
216595011991	Int/Topo IB signature motif; other site
216595011993	nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321
216595011994	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
216595011995	active site
216595011997	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595011998	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
216595011999	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
216595012000	homodimer interface [polypeptide binding]; other site
216595012001	NAD binding pocket [chemical binding]; other site
216595012002	ATP binding pocket [chemical binding]; other site
216595012003	Mg binding site [ion binding]; other site
216595012004	active-site loop [active]
216595012006	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
216595012007	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
216595012009	1 probable transmembrane helix predicted for PFLU2522 by TMHMM2.0 at aa 5-27
216595012010	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
216595012011	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
216595012013	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
216595012014	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
216595012015	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
216595012018	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
216595012019	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
216595012020	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595012021	dimer interface [polypeptide binding]; other site
216595012022	conserved gate region; other site
216595012023	putative PBP binding loops; other site
216595012024	ABC-ATPase subunit interface; other site
216595012026	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
216595012027	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595012028	dimer interface [polypeptide binding]; other site
216595012029	conserved gate region; other site
216595012030	putative PBP binding loops; other site
216595012031	ABC-ATPase subunit interface; other site
216595012033	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595012034	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
216595012035	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216595012036	Walker A/P-loop; other site
216595012037	ATP binding site [chemical binding]; other site
216595012038	Q-loop/lid; other site
216595012039	ABC transporter signature motif; other site
216595012040	Walker B; other site
216595012041	D-loop; other site
216595012042	H-loop/switch region; other site
216595012043	TOBE domain; Region: TOBE_2; pfam08402
216595012046	PS00211 ABC transporters family signature.
216595012047	PS00017 ATP/GTP-binding site motif A (P-loop).
216595012048	Transcriptional regulator [Transcription]; Region: IclR; COG1414
216595012049	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
216595012050	putative DNA binding site [nucleotide binding]; other site
216595012051	putative Zn2+ binding site [ion binding]; other site
216595012052	Bacterial transcriptional regulator; Region: IclR; pfam01614
216595012055	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
216595012056	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595012057	active site
216595012058	phosphorylation site [posttranslational modification]
216595012059	intermolecular recognition site; other site
216595012060	dimerization interface [polypeptide binding]; other site
216595012061	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216595012062	DNA binding residues [nucleotide binding]
216595012063	dimerization interface [polypeptide binding]; other site
216595012065	PS00622 Bacterial regulatory proteins, luxR family signature.
216595012067	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
216595012068	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595012069	DNA-binding site [nucleotide binding]; DNA binding site
216595012070	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
216595012072	PS00043 Bacterial regulatory proteins, gntR family signature.
216595012074	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
216595012075	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
216595012076	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595012077	dimer interface [polypeptide binding]; other site
216595012078	putative CheW interface [polypeptide binding]; other site
216595012081	Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069
216595012083	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
216595012084	acylamide amidohydrolase; Provisional; Region: amiE; PRK13286
216595012085	aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565
216595012086	multimer interface [polypeptide binding]; other site
216595012087	active site
216595012088	catalytic triad [active]
216595012089	dimer interface [polypeptide binding]; other site
216595012091	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
216595012092	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595012093	Walker A motif; other site
216595012094	ATP binding site [chemical binding]; other site
216595012095	Walker B motif; other site
216595012097	PS00017 ATP/GTP-binding site motif A (P-loop).
216595012098	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
216595012099	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
216595012100	12 probable transmembrane helices predicted for PFLU2538 by TMHMM2.0 at aa 12-34, 54-76, 89-111, 138-157, 164-186, 191-213, 245-267, 287-309, 322-344, 359-381, 388-410 and 420-442
216595012103	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
216595012104	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216595012106	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595012107	Major Facilitator Superfamily; Region: MFS_1; pfam07690
216595012108	11 probable transmembrane helices predicted for PFLU2540 by TMHMM2.0 at aa 50-72, 79-101, 116-135, 142-161, 203-225, 245-267, 282-304, 316-334, 339-361, 374-396 and 401-423
216595012110	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
216595012111	HicB family; Region: HicB; pfam05534
216595012113	YcfA-like protein; Region: YcfA; cl00752
216595012114	Condensation domain; Region: Condensation; pfam00668
216595012115	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
216595012116	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
216595012117	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
216595012118	acyl-activating enzyme (AAE) consensus motif; other site
216595012119	AMP binding site [chemical binding]; other site
216595012120	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
216595012121	Condensation domain; Region: Condensation; pfam00668
216595012122	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
216595012123	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
216595012124	Condensation domain; Region: Condensation; pfam00668
216595012125	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
216595012126	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
216595012127	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
216595012128	acyl-activating enzyme (AAE) consensus motif; other site
216595012129	AMP binding site [chemical binding]; other site
216595012130	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
216595012131	Condensation domain; Region: Condensation; pfam00668
216595012132	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
216595012133	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
216595012134	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
216595012135	acyl-activating enzyme (AAE) consensus motif; other site
216595012136	AMP binding site [chemical binding]; other site
216595012137	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
216595012138	Condensation domain; Region: Condensation; pfam00668
216595012139	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
216595012140	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
216595012141	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
216595012142	acyl-activating enzyme (AAE) consensus motif; other site
216595012143	AMP binding site [chemical binding]; other site
216595012144	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
216595012146	PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature.
216595012148	PS00455 Putative AMP-binding domain signature.
216595012150	PS00012 Phosphopantetheine attachment site.
216595012153	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595012155	PS00455 Putative AMP-binding domain signature.
216595012159	PS00455 Putative AMP-binding domain signature.
216595012160	PS00044 Bacterial regulatory proteins, lysR family signature.
216595012162	PS00012 Phosphopantetheine attachment site.
216595012164	PS00041 Bacterial regulatory proteins, araC family signature.
216595012166	PS00455 Putative AMP-binding domain signature.
216595012168	PS00012 Phosphopantetheine attachment site.
216595012169	peptide synthase; Provisional; Region: PRK12467
216595012170	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
216595012171	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
216595012172	acyl-activating enzyme (AAE) consensus motif; other site
216595012173	AMP binding site [chemical binding]; other site
216595012174	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
216595012175	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
216595012176	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
216595012177	acyl-activating enzyme (AAE) consensus motif; other site
216595012178	AMP binding site [chemical binding]; other site
216595012179	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
216595012180	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
216595012181	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
216595012182	acyl-activating enzyme (AAE) consensus motif; other site
216595012183	AMP binding site [chemical binding]; other site
216595012184	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
216595012187	PS00455 Putative AMP-binding domain signature.
216595012189	PS00012 Phosphopantetheine attachment site.
216595012192	PS00455 Putative AMP-binding domain signature.
216595012194	PS00012 Phosphopantetheine attachment site.
216595012198	PS00455 Putative AMP-binding domain signature.
216595012201	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
216595012202	Secretin and TonB N terminus short domain; Region: STN; smart00965
216595012203	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216595012204	N-terminal plug; other site
216595012205	ligand-binding site [chemical binding]; other site
216595012207	PS01156 TonB-dependent receptor proteins signature 2.
216595012210	cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194
216595012211	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
216595012212	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
216595012213	Walker A/P-loop; other site
216595012214	ATP binding site [chemical binding]; other site
216595012215	Q-loop/lid; other site
216595012216	ABC transporter signature motif; other site
216595012217	Walker B; other site
216595012218	D-loop; other site
216595012219	H-loop/switch region; other site
216595012221	PS00017 ATP/GTP-binding site motif A (P-loop).
216595012223	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
216595012224	catalytic site [active]
216595012225	Uncharacterized conserved protein [Function unknown]; Region: COG1262
216595012226	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
216595012228	PS00178 Aminoacyl-transfer RNA synthetases class-I signature.
216595012229	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
216595012230	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
216595012231	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
216595012232	catalytic residue [active]
216595012234	PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site.
216595012235	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
216595012236	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
216595012237	active site
216595012238	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
216595012240	1 probable transmembrane helix predicted for PFLU2550 by TMHMM2.0 at aa 12-34
216595012241	1 probable transmembrane helix predicted for PFLU2551 by TMHMM2.0 at aa 7-26
216595012242	Condensation domain; Region: Condensation; pfam00668
216595012243	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
216595012244	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
216595012245	acyl-activating enzyme (AAE) consensus motif; other site
216595012246	AMP binding site [chemical binding]; other site
216595012247	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
216595012248	Condensation domain; Region: Condensation; pfam00668
216595012249	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
216595012250	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
216595012251	acyl-activating enzyme (AAE) consensus motif; other site
216595012252	AMP binding site [chemical binding]; other site
216595012253	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
216595012254	Condensation domain; Region: Condensation; pfam00668
216595012255	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
216595012256	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
216595012257	acyl-activating enzyme (AAE) consensus motif; other site
216595012258	AMP binding site [chemical binding]; other site
216595012259	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
216595012260	Condensation domain; Region: Condensation; pfam00668
216595012261	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
216595012262	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
216595012263	acyl-activating enzyme (AAE) consensus motif; other site
216595012264	AMP binding site [chemical binding]; other site
216595012265	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
216595012268	PS00455 Putative AMP-binding domain signature.
216595012270	PS00012 Phosphopantetheine attachment site.
216595012272	PS00659 Glycosyl hydrolases family 5 signature.
216595012274	PS00455 Putative AMP-binding domain signature.
216595012278	PS00455 Putative AMP-binding domain signature.
216595012282	PS00455 Putative AMP-binding domain signature.
216595012284	Condensation domain; Region: Condensation; pfam00668
216595012285	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
216595012286	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
216595012287	acyl-activating enzyme (AAE) consensus motif; other site
216595012288	AMP binding site [chemical binding]; other site
216595012289	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
216595012290	Condensation domain; Region: Condensation; pfam00668
216595012291	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
216595012292	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
216595012293	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
216595012294	acyl-activating enzyme (AAE) consensus motif; other site
216595012295	AMP binding site [chemical binding]; other site
216595012296	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
216595012297	Condensation domain; Region: Condensation; pfam00668
216595012298	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
216595012299	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
216595012300	acyl-activating enzyme (AAE) consensus motif; other site
216595012301	AMP binding site [chemical binding]; other site
216595012302	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
216595012303	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
216595012304	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
216595012307	PS00455 Putative AMP-binding domain signature.
216595012309	PS00012 Phosphopantetheine attachment site.
216595012312	PS00455 Putative AMP-binding domain signature.
216595012316	PS00455 Putative AMP-binding domain signature.
216595012317	PS00070 Aldehyde dehydrogenases cysteine active site.
216595012319	PS00012 Phosphopantetheine attachment site.
216595012322	PS00120 Lipases, serine active site.
216595012323	macrolide transporter subunit MacA; Provisional; Region: PRK11578
216595012324	HlyD family secretion protein; Region: HlyD_3; pfam13437
216595012325	1 probable transmembrane helix predicted for PFLU2555 by TMHMM2.0 at aa 51-70
216595012327	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
216595012328	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
216595012329	Walker A/P-loop; other site
216595012330	ATP binding site [chemical binding]; other site
216595012331	Q-loop/lid; other site
216595012332	ABC transporter signature motif; other site
216595012333	Walker B; other site
216595012334	D-loop; other site
216595012335	H-loop/switch region; other site
216595012336	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
216595012337	FtsX-like permease family; Region: FtsX; pfam02687
216595012339	PS00017 ATP/GTP-binding site motif A (P-loop).
216595012340	PS00211 ABC transporters family signature.
216595012342	3 probable transmembrane helices predicted for PFLU2556 by TMHMM2.0 at aa 531-553, 576-598 and 613-635
216595012343	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
216595012344	DNA binding residues [nucleotide binding]
216595012345	dimerization interface [polypeptide binding]; other site
216595012347	methionine gamma-lyase; Provisional; Region: PRK07503
216595012348	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
216595012349	homodimer interface [polypeptide binding]; other site
216595012350	substrate-cofactor binding pocket; other site
216595012351	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595012352	catalytic residue [active]
216595012354	PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site.
216595012355	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
216595012356	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
216595012357	putative DNA binding site [nucleotide binding]; other site
216595012358	putative Zn2+ binding site [ion binding]; other site
216595012359	AsnC family; Region: AsnC_trans_reg; pfam01037
216595012361	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
216595012362	Uncharacterized conserved protein [Function unknown]; Region: COG2128
216595012364	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
216595012365	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216595012366	N-terminal plug; other site
216595012367	ligand-binding site [chemical binding]; other site
216595012370	Helix-turn-helix domain; Region: HTH_18; pfam12833
216595012372	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
216595012373	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
216595012375	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
216595012376	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
216595012378	1 probable transmembrane helix predicted for PFLU2566 by TMHMM2.0 at aa 13-35
216595012379	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
216595012380	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595012381	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
216595012382	dimerization interface [polypeptide binding]; other site
216595012383	substrate binding pocket [chemical binding]; other site
216595012386	PS00044 Bacterial regulatory proteins, lysR family signature.
216595012387	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
216595012388	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
216595012389	active site
216595012390	catalytic tetrad [active]
216595012392	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
216595012393	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216595012394	NAD(P) binding site [chemical binding]; other site
216595012395	active site
216595012397	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
216595012398	putative hydrophobic ligand binding site [chemical binding]; other site
216595012399	protein interface [polypeptide binding]; other site
216595012400	gate; other site
216595012402	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
216595012403	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595012404	dimerization interface [polypeptide binding]; other site
216595012405	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595012406	dimer interface [polypeptide binding]; other site
216595012407	phosphorylation site [posttranslational modification]
216595012408	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595012409	ATP binding site [chemical binding]; other site
216595012410	Mg2+ binding site [ion binding]; other site
216595012411	G-X-G motif; other site
216595012415	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
216595012416	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595012417	active site
216595012418	phosphorylation site [posttranslational modification]
216595012419	intermolecular recognition site; other site
216595012420	dimerization interface [polypeptide binding]; other site
216595012421	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216595012422	DNA binding site [nucleotide binding]
216595012425	4 probable transmembrane helices predicted for PFLU2573 by TMHMM2.0 at aa 69-91, 111-133, 154-176 and 304-326
216595012426	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
216595012427	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
216595012428	putative active site [active]
216595012431	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
216595012432	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
216595012433	substrate binding site [chemical binding]; other site
216595012434	ATP binding site [chemical binding]; other site
216595012435	Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863
216595012436	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892
216595012438	PS00584 pfkB family of carbohydrate kinases signature 2.
216595012439	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
216595012441	PS00215 Mitochondrial energy transfer proteins signature.
216595012442	KduI/IolB family; Region: KduI; pfam04962
216595012444	Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130
216595012446	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
216595012447	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
216595012448	PYR/PP interface [polypeptide binding]; other site
216595012449	dimer interface [polypeptide binding]; other site
216595012450	TPP binding site [chemical binding]; other site
216595012451	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
216595012452	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
216595012453	TPP-binding site; other site
216595012456	PS00017 ATP/GTP-binding site motif A (P-loop).
216595012458	PS00187 Thiamine pyrophosphate enzymes signature.
216595012459	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
216595012460	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
216595012461	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
216595012464	putative oxidoreductase; Provisional; Region: PRK11579
216595012465	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
216595012466	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
216595012469	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
216595012470	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
216595012471	putative ligand binding site [chemical binding]; other site
216595012473	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
216595012474	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
216595012475	Walker A/P-loop; other site
216595012476	ATP binding site [chemical binding]; other site
216595012477	Q-loop/lid; other site
216595012478	ABC transporter signature motif; other site
216595012479	Walker B; other site
216595012480	D-loop; other site
216595012481	H-loop/switch region; other site
216595012482	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
216595012484	PS00017 ATP/GTP-binding site motif A (P-loop).
216595012486	PS00211 ABC transporters family signature.
216595012487	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
216595012488	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
216595012489	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
216595012490	TM-ABC transporter signature motif; other site
216595012491	8 probable transmembrane helices predicted for PFLU2585 by TMHMM2.0 at aa 26-48, 58-80, 87-104, 119-136, 141-163, 183-205, 235-257 and 290-312
216595012493	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
216595012495	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
216595012496	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595012497	dimer interface [polypeptide binding]; other site
216595012498	putative CheW interface [polypeptide binding]; other site
216595012499	1 probable transmembrane helix predicted for PFLU2587 by TMHMM2.0 at aa 56-78
216595012501	Protein of unknown function (DUF2789); Region: DUF2789; pfam10982
216595012502	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
216595012503	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
216595012505	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
216595012506	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216595012507	N-terminal plug; other site
216595012508	ligand-binding site [chemical binding]; other site
216595012510	PS01156 TonB-dependent receptor proteins signature 2.
216595012512	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595012513	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
216595012514	1 probable transmembrane helix predicted for PFLU2594 by TMHMM2.0 at aa 15-37
216595012515	Protein of unknown function (DUF3995); Region: DUF3995; pfam13160
216595012516	4 probable transmembrane helices predicted for PFLU2595 by TMHMM2.0 at aa 5-27, 56-78, 85-104 and 126-144
216595012517	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
216595012518	RHS Repeat; Region: RHS_repeat; pfam05593
216595012519	RHS Repeat; Region: RHS_repeat; cl11982
216595012520	RHS Repeat; Region: RHS_repeat; cl11982
216595012521	RHS Repeat; Region: RHS_repeat; cl11982
216595012522	RHS Repeat; Region: RHS_repeat; pfam05593
216595012523	RHS Repeat; Region: RHS_repeat; pfam05593
216595012524	RHS Repeat; Region: RHS_repeat; pfam05593
216595012525	RHS protein; Region: RHS; pfam03527
216595012526	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
216595012540	1 probable transmembrane helix predicted for PFLU2597 by TMHMM2.0 at aa 285-307
216595012541	Secretin and TonB N terminus short domain; Region: STN; smart00965
216595012542	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
216595012543	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216595012544	N-terminal plug; other site
216595012545	ligand-binding site [chemical binding]; other site
216595012549	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
216595012550	1 probable transmembrane helix predicted for PFLU2599 by TMHMM2.0 at aa 7-26
216595012551	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595012552	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595012553	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
216595012554	dimerization interface [polypeptide binding]; other site
216595012557	PS00044 Bacterial regulatory proteins, lysR family signature.
216595012558	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
216595012559	Putative ammonia monooxygenase; Region: AmoA; pfam05145
216595012560	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
216595012561	6 probable transmembrane helices predicted for PFLU2601 by TMHMM2.0 at aa 7-29, 82-104, 148-170, 174-193, 259-281 and 301-323
216595012563	PS00435 Peroxidases proximal heme-ligand signature.
216595012564	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
216595012565	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
216595012567	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
216595012568	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595012570	PS00041 Bacterial regulatory proteins, araC family signature.
216595012572	1 probable transmembrane helix predicted for PFLU2605 by TMHMM2.0 at aa 15-33
216595012573	low G+C content region (38.77%)
216595012574	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595012575	PAS fold; Region: PAS_3; pfam08447
216595012576	putative active site [active]
216595012577	heme pocket [chemical binding]; other site
216595012578	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
216595012579	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216595012580	metal binding site [ion binding]; metal-binding site
216595012581	active site
216595012582	I-site; other site
216595012585	1 probable transmembrane helix predicted for PFLU2607 by TMHMM2.0 at aa 34-53
216595012586	RNA polymerase sigma factor; Reviewed; Region: PRK05602
216595012587	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
216595012590	1 probable transmembrane helix predicted for PFLU2610 by TMHMM2.0 at aa 85-107
216595012591	Heavy-metal resistance; Region: Metal_resist; pfam13801
216595012592	1 probable transmembrane helix predicted for PFLU2611 by TMHMM2.0 at aa 9-31
216595012593	SCP-2 sterol transfer family; Region: SCP2; pfam02036
216595012595	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
216595012596	catalytic core [active]
216595012598	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
216595012599	putative inner membrane peptidase; Provisional; Region: PRK11778
216595012600	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
216595012601	tandem repeat interface [polypeptide binding]; other site
216595012602	oligomer interface [polypeptide binding]; other site
216595012603	active site residues [active]
216595012605	1 probable transmembrane helix predicted for PFLU2614 by TMHMM2.0 at aa 7-29
216595012607	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
216595012608	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
216595012609	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
216595012610	Transporter associated domain; Region: CorC_HlyC; smart01091
216595012612	7 probable transmembrane helices predicted for PFLU2615 by TMHMM2.0 at aa 13-35, 48-70, 85-99, 120-139, 154-171, 178-200 and 205-227
216595012615	low G+C content region (37.69%)
216595012616	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
216595012617	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595012618	substrate binding pocket [chemical binding]; other site
216595012619	membrane-bound complex binding site; other site
216595012620	hinge residues; other site
216595012622	PS01039 Bacterial extracellular solute-binding proteins, family 3 signature.
216595012623	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595012624	dimer interface [polypeptide binding]; other site
216595012625	conserved gate region; other site
216595012626	putative PBP binding loops; other site
216595012627	ABC-ATPase subunit interface; other site
216595012629	4 probable transmembrane helices predicted for PFLU2618 by TMHMM2.0 at aa 20-42, 55-77, 92-114 and 187-209
216595012630	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
216595012631	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595012632	dimer interface [polypeptide binding]; other site
216595012633	conserved gate region; other site
216595012634	putative PBP binding loops; other site
216595012635	ABC-ATPase subunit interface; other site
216595012637	3 probable transmembrane helices predicted for PFLU2619 by TMHMM2.0 at aa 26-48, 69-91 and 191-213
216595012638	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595012639	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
216595012640	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
216595012641	Walker A/P-loop; other site
216595012642	ATP binding site [chemical binding]; other site
216595012643	Q-loop/lid; other site
216595012644	ABC transporter signature motif; other site
216595012645	Walker B; other site
216595012646	D-loop; other site
216595012647	H-loop/switch region; other site
216595012649	PS00017 ATP/GTP-binding site motif A (P-loop).
216595012650	PS00211 ABC transporters family signature.
216595012651	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
216595012652	homotrimer interaction site [polypeptide binding]; other site
216595012653	putative active site [active]
216595012655	Transcriptional regulator [Transcription]; Region: IclR; COG1414
216595012656	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
216595012657	Bacterial transcriptional regulator; Region: IclR; pfam01614
216595012660	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
216595012661	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818
216595012662	dimer interface [polypeptide binding]; other site
216595012663	active site
216595012664	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
216595012665	substrate binding site [chemical binding]; other site
216595012666	catalytic residue [active]
216595012667	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
216595012668	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
216595012669	substrate binding site [chemical binding]; other site
216595012670	ATP binding site [chemical binding]; other site
216595012672	PS00584 pfkB family of carbohydrate kinases signature 2.
216595012673	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
216595012675	PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature.
216595012676	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
216595012677	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
216595012678	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595012679	putative active site [active]
216595012680	heme pocket [chemical binding]; other site
216595012681	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595012682	putative active site [active]
216595012683	heme pocket [chemical binding]; other site
216595012684	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595012685	dimer interface [polypeptide binding]; other site
216595012686	phosphorylation site [posttranslational modification]
216595012687	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595012688	ATP binding site [chemical binding]; other site
216595012689	Mg2+ binding site [ion binding]; other site
216595012690	G-X-G motif; other site
216595012691	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595012692	Response regulator receiver domain; Region: Response_reg; pfam00072
216595012693	active site
216595012694	phosphorylation site [posttranslational modification]
216595012695	intermolecular recognition site; other site
216595012696	dimerization interface [polypeptide binding]; other site
216595012703	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
216595012704	Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943
216595012705	acyl-activating enzyme (AAE) consensus motif; other site
216595012706	putative AMP binding site [chemical binding]; other site
216595012707	putative active site [active]
216595012708	putative CoA binding site [chemical binding]; other site
216595012710	PS00455 Putative AMP-binding domain signature.
216595012711	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
216595012712	d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940
216595012713	NAD binding site [chemical binding]; other site
216595012714	homotetramer interface [polypeptide binding]; other site
216595012715	homodimer interface [polypeptide binding]; other site
216595012716	substrate binding site [chemical binding]; other site
216595012717	active site
216595012719	PS00061 Short-chain dehydrogenases/reductases family signature.
216595012720	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
216595012722	PAS domain; Region: PAS; smart00091
216595012723	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
216595012724	putative active site [active]
216595012725	heme pocket [chemical binding]; other site
216595012726	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595012727	Walker B motif; other site
216595012728	arginine finger; other site
216595012729	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
216595012731	PS00688 Sigma-54 interaction domain C-terminal part signature.
216595012733	PS00676 Sigma-54 interaction domain ATP-binding region B signature.
216595012734	PS00675 Sigma-54 interaction domain ATP-binding region A signature.
216595012736	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
216595012737	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
216595012738	Walker A/P-loop; other site
216595012739	ATP binding site [chemical binding]; other site
216595012740	Q-loop/lid; other site
216595012741	ABC transporter signature motif; other site
216595012742	Walker B; other site
216595012743	D-loop; other site
216595012744	H-loop/switch region; other site
216595012745	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
216595012746	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
216595012747	Walker A/P-loop; other site
216595012748	ATP binding site [chemical binding]; other site
216595012749	Q-loop/lid; other site
216595012750	ABC transporter signature motif; other site
216595012751	Walker B; other site
216595012752	D-loop; other site
216595012753	H-loop/switch region; other site
216595012754	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
216595012757	PS00211 ABC transporters family signature.
216595012758	PS00017 ATP/GTP-binding site motif A (P-loop).
216595012761	PS00211 ABC transporters family signature.
216595012762	PS00017 ATP/GTP-binding site motif A (P-loop).
216595012763	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
216595012764	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595012765	dimer interface [polypeptide binding]; other site
216595012766	conserved gate region; other site
216595012767	putative PBP binding loops; other site
216595012768	ABC-ATPase subunit interface; other site
216595012770	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
216595012771	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595012772	dimer interface [polypeptide binding]; other site
216595012773	conserved gate region; other site
216595012774	putative PBP binding loops; other site
216595012775	ABC-ATPase subunit interface; other site
216595012777	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
216595012778	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
216595012779	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
216595012781	1 probable transmembrane helix predicted for PFLU2634 by TMHMM2.0 at aa 21-43
216595012782	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
216595012784	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
216595012785	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
216595012786	Walker A/P-loop; other site
216595012787	ATP binding site [chemical binding]; other site
216595012788	Q-loop/lid; other site
216595012789	ABC transporter signature motif; other site
216595012790	Walker B; other site
216595012791	D-loop; other site
216595012792	H-loop/switch region; other site
216595012793	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
216595012794	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
216595012795	Walker A/P-loop; other site
216595012796	ATP binding site [chemical binding]; other site
216595012797	Q-loop/lid; other site
216595012798	ABC transporter signature motif; other site
216595012799	Walker B; other site
216595012800	D-loop; other site
216595012801	H-loop/switch region; other site
216595012802	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
216595012805	PS00211 ABC transporters family signature.
216595012806	PS00017 ATP/GTP-binding site motif A (P-loop).
216595012809	PS00211 ABC transporters family signature.
216595012810	PS00017 ATP/GTP-binding site motif A (P-loop).
216595012811	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
216595012812	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595012813	dimer interface [polypeptide binding]; other site
216595012814	conserved gate region; other site
216595012815	putative PBP binding loops; other site
216595012816	ABC-ATPase subunit interface; other site
216595012818	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595012819	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
216595012820	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595012821	dimer interface [polypeptide binding]; other site
216595012822	conserved gate region; other site
216595012823	putative PBP binding loops; other site
216595012824	ABC-ATPase subunit interface; other site
216595012826	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
216595012827	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
216595012829	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
216595012830	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
216595012832	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
216595012833	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
216595012834	N-acetyl-D-glucosamine binding site [chemical binding]; other site
216595012835	catalytic residue [active]
216595012836	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
216595012837	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
216595012841	PS00922 Prokaryotic transglycosylases signature.
216595012843	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595012844	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
216595012846	Methyltransferase domain; Region: Methyltransf_23; pfam13489
216595012847	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
216595012848	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
216595012849	RNA/DNA hybrid binding site [nucleotide binding]; other site
216595012850	active site
216595012852	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
216595012853	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
216595012854	active site
216595012855	catalytic site [active]
216595012856	substrate binding site [chemical binding]; other site
216595012858	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
216595012859	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
216595012860	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
216595012861	homodimer interface [polypeptide binding]; other site
216595012862	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595012863	catalytic residue [active]
216595012864	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
216595012867	PS00703 Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site.
216595012869	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216595012870	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
216595012871	Coenzyme A binding pocket [chemical binding]; other site
216595012873	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595012874	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595012875	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
216595012876	dimerization interface [polypeptide binding]; other site
216595012878	Predicted flavoprotein [General function prediction only]; Region: COG0431
216595012879	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
216595012881	pyruvate dehydrogenase; Provisional; Region: PRK09124
216595012882	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
216595012883	PYR/PP interface [polypeptide binding]; other site
216595012884	dimer interface [polypeptide binding]; other site
216595012885	tetramer interface [polypeptide binding]; other site
216595012886	TPP binding site [chemical binding]; other site
216595012887	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
216595012888	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
216595012889	TPP-binding site [chemical binding]; other site
216595012891	PS00187 Thiamine pyrophosphate enzymes signature.
216595012894	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
216595012895	Old yellow enzyme (OYE)-related FMN binding domain, group 2.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733
216595012896	putative active site [active]
216595012897	putative FMN binding site [chemical binding]; other site
216595012898	putative substrate binding site [chemical binding]; other site
216595012899	putative catalytic residue [active]
216595012901	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
216595012902	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
216595012903	DNA binding residues [nucleotide binding]
216595012905	PS00552 Bacterial regulatory proteins, merR family signature.
216595012907	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
216595012909	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
216595012910	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
216595012911	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
216595012916	1 probable transmembrane helix predicted for PFLU2658 by TMHMM2.0 at aa 70-89
216595012917	Protein of unknown function (DUF2970); Region: DUF2970; pfam11174
216595012920	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
216595012921	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
216595012922	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
216595012923	substrate binding pocket [chemical binding]; other site
216595012924	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
216595012925	B12 binding site [chemical binding]; other site
216595012926	cobalt ligand [ion binding]; other site
216595012927	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
216595012933	Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934
216595012934	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595012936	PS00190 Cytochrome c family heme-binding site signature.
216595012937	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
216595012938	IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341
216595012939	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
216595012942	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
216595012943	active site
216595012944	SAM binding site [chemical binding]; other site
216595012945	homodimer interface [polypeptide binding]; other site
216595012947	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595012948	PS00839 Uroporphyrin-III C-methyltransferase signature 1.
216595012949	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
216595012951	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
216595012952	Probable cobalt transporter subunit (CbtB); Region: CbtB; pfam09489
216595012953	1 probable transmembrane helix predicted for PFLU2668 by TMHMM2.0 at aa 21-43
216595012954	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595012955	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
216595012956	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
216595012957	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
216595012959	PS00017 ATP/GTP-binding site motif A (P-loop).
216595012961	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
216595012962	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
216595012963	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
216595012966	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595012967	Walker A motif; other site
216595012968	ATP binding site [chemical binding]; other site
216595012969	Walker B motif; other site
216595012970	arginine finger; other site
216595012972	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
216595012973	metal ion-dependent adhesion site (MIDAS); other site
216595012974	Domain of unknown function (DUF1853); Region: DUF1853; pfam08907
216595012976	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231
216595012977	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
216595012979	Pseudomonas aeruginosa PA3087 and related proteins, metallophosphatase domain; Region: MPP_PA3087; cd07413
216595012980	active site
216595012981	metal binding site [ion binding]; metal-binding site
216595012983	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
216595012984	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595012985	ATP binding site [chemical binding]; other site
216595012986	Walker B motif; other site
216595012987	arginine finger; other site
216595012989	PS00017 ATP/GTP-binding site motif A (P-loop).
216595012990	PS00674 AAA-protein family signature.
216595012991	4 probable transmembrane helices predicted for PFLU2677 by TMHMM2.0 at aa 25-47, 60-82, 92-111 and 131-153
216595012992	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
216595012993	TPR motif; other site
216595012994	binding surface
216595012995	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
216595012996	binding surface
216595012997	Tetratricopeptide repeat; Region: TPR_16; pfam13432
216595012998	TPR motif; other site
216595013001	2 probable transmembrane helices predicted for PFLU2678 by TMHMM2.0 at aa 252-271 and 284-303
216595013002	Protein of unknown function (DUF1315); Region: DUF1315; cl01215
216595013004	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
216595013005	aminopeptidase N; Provisional; Region: pepN; PRK14015
216595013006	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
216595013007	active site
216595013008	Zn binding site [ion binding]; other site
216595013010	PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.
216595013011	HTH domain; Region: HTH_11; pfam08279
216595013012	Predicted transcriptional regulator [Transcription]; Region: COG2378
216595013013	WYL domain; Region: WYL; pfam13280
216595013015	SnoaL-like domain; Region: SnoaL_2; pfam12680
216595013016	Predicted ATPase [General function prediction only]; Region: COG1485
216595013018	PS00017 ATP/GTP-binding site motif A (P-loop).
216595013019	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216595013020	Coenzyme A binding pocket [chemical binding]; other site
216595013022	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
216595013023	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216595013024	N-terminal plug; other site
216595013025	ligand-binding site [chemical binding]; other site
216595013028	hypothetical protein; Provisional; Region: PRK10649
216595013029	Sulfatase; Region: Sulfatase; pfam00884
216595013031	proteasome-activating nucleotidase; Provisional; Region: PRK03992
216595013032	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
216595013033	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
216595013037	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853
216595013038	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
216595013039	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
216595013041	PS00069 Glucose-6-phosphate dehydrogenase active site.
216595013043	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
216595013044	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216595013045	active site
216595013046	motif I; other site
216595013047	motif II; other site
216595013048	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
216595013050	PS01229 Hypothetical cof family signature 2.
216595013051	Protein of unknown function (DUF1652); Region: DUF1652; pfam07865
216595013052	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
216595013053	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595013054	Walker A motif; other site
216595013055	ATP binding site [chemical binding]; other site
216595013056	Walker B motif; other site
216595013057	arginine finger; other site
216595013058	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
216595013059	PS00190 Cytochrome c family heme-binding site signature.
216595013061	PS00675 Sigma-54 interaction domain ATP-binding region A signature.
216595013062	PS00676 Sigma-54 interaction domain ATP-binding region B signature.
216595013063	PS00688 Sigma-54 interaction domain C-terminal part signature.
216595013065	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423
216595013066	putative active site [active]
216595013068	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595013069	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595013070	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
216595013071	FecR protein; Region: FecR; pfam04773
216595013073	1 probable transmembrane helix predicted for PFLU2702 by TMHMM2.0 at aa 94-116
216595013074	PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.
216595013075	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
216595013077	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
216595013079	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595013080	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595013081	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464
216595013082	putative substrate binding pocket [chemical binding]; other site
216595013083	putative dimerization interface [polypeptide binding]; other site
216595013086	PS00044 Bacterial regulatory proteins, lysR family signature.
216595013087	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
216595013088	Predicted amidohydrolase [General function prediction only]; Region: COG0388
216595013089	putative active site [active]
216595013090	catalytic triad [active]
216595013091	putative dimer interface [polypeptide binding]; other site
216595013093	PS00921 Nitrilases / cyanide hydratase active site signature.
216595013094	Water Stress and Hypersensitive response; Region: WHy; smart00769
216595013095	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595013096	xanthine permease; Region: pbuX; TIGR03173
216595013098	PS01116 Xanthine/uracil permeases family signature.
216595013099	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
216595013100	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595013101	dimerization interface [polypeptide binding]; other site
216595013102	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
216595013103	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595013104	dimer interface [polypeptide binding]; other site
216595013105	putative CheW interface [polypeptide binding]; other site
216595013106	2 probable transmembrane helices predicted for PFLU2711 by TMHMM2.0 at aa 30-52 and 210-232
216595013109	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
216595013110	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
216595013111	dimerization interface [polypeptide binding]; other site
216595013112	ligand binding site [chemical binding]; other site
216595013113	NADP binding site [chemical binding]; other site
216595013114	catalytic site [active]
216595013117	PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature.
216595013118	PS00017 ATP/GTP-binding site motif A (P-loop).
216595013119	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595013120	D-galactonate transporter; Region: 2A0114; TIGR00893
216595013121	putative substrate translocation pore; other site
216595013123	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595013124	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
216595013125	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
216595013126	substrate binding site [chemical binding]; other site
216595013127	ATP binding site [chemical binding]; other site
216595013129	PS00584 pfkB family of carbohydrate kinases signature 2.
216595013130	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
216595013132	Transcriptional regulators [Transcription]; Region: PurR; COG1609
216595013133	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
216595013134	DNA binding site [nucleotide binding]
216595013135	domain linker motif; other site
216595013136	Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283
216595013137	putative dimerization interface [polypeptide binding]; other site
216595013138	putative ligand binding site [chemical binding]; other site
216595013141	PS00356 Bacterial regulatory proteins, lacI family signature.
216595013142	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
216595013144	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
216595013145	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
216595013146	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595013147	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595013148	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595013151	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
216595013153	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
216595013154	Protein export membrane protein; Region: SecD_SecF; cl14618
216595013156	multidrug efflux system protein MdtE; Provisional; Region: PRK09859
216595013157	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
216595013158	HlyD family secretion protein; Region: HlyD_3; pfam13437
216595013160	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595013161	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
216595013162	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595013163	active site
216595013164	phosphorylation site [posttranslational modification]
216595013165	intermolecular recognition site; other site
216595013166	dimerization interface [polypeptide binding]; other site
216595013167	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216595013168	DNA binding site [nucleotide binding]
216595013171	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
216595013172	dimerization interface [polypeptide binding]; other site
216595013173	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595013174	dimer interface [polypeptide binding]; other site
216595013175	phosphorylation site [posttranslational modification]
216595013176	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595013177	ATP binding site [chemical binding]; other site
216595013178	Mg2+ binding site [ion binding]; other site
216595013179	G-X-G motif; other site
216595013180	2 probable transmembrane helices predicted for PFLU2723 by TMHMM2.0 at aa 5-27 and 136-158
216595013184	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343
216595013185	Anti-sigma-K factor rskA; Region: RskA; pfam10099
216595013186	1 probable transmembrane helix predicted for PFLU2724 by TMHMM2.0 at aa 81-103
216595013187	RNA polymerase sigma factor; Provisional; Region: PRK12537
216595013188	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
216595013189	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
216595013190	DNA binding residues [nucleotide binding]
216595013193	Protein of unknown function (DUF3455); Region: DUF3455; pfam11937
216595013194	Methyltransferase domain; Region: Methyltransf_31; pfam13847
216595013195	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595013196	S-adenosylmethionine binding site [chemical binding]; other site
216595013198	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
216595013199	6 probable transmembrane helices predicted for PFLU2728 by TMHMM2.0 at aa 4-26, 33-55, 75-97, 109-131, 146-180 and 215-237
216595013201	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
216595013202	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
216595013203	Flavin binding site [chemical binding]; other site
216595013206	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
216595013207	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
216595013208	active site
216595013209	dimer interface [polypeptide binding]; other site
216595013210	non-prolyl cis peptide bond; other site
216595013211	insertion regions; other site
216595013213	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
216595013214	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216595013215	Coenzyme A binding pocket [chemical binding]; other site
216595013217	RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401
216595013218	Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189
216595013219	ATP-grasp domain; Region: ATP-grasp_4; cl17255
216595013221	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
216595013222	active site
216595013224	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
216595013226	PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site.
216595013227	low G+C content region (40.79%)
216595013228	Protein of unknown function (DUF1652); Region: DUF1652; pfam07865
216595013230	Protein of unknown function (DUF2790); Region: DUF2790; pfam10976
216595013232	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
216595013233	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
216595013234	putative substrate binding site [chemical binding]; other site
216595013235	putative ATP binding site [chemical binding]; other site
216595013237	PS00584 pfkB family of carbohydrate kinases signature 2.
216595013238	D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809
216595013239	N- and C-terminal domain interface [polypeptide binding]; other site
216595013240	D-xylulose kinase; Region: XylB; TIGR01312
216595013241	active site
216595013242	MgATP binding site [chemical binding]; other site
216595013243	catalytic site [active]
216595013244	metal binding site [ion binding]; metal-binding site
216595013245	xylulose binding site [chemical binding]; other site
216595013246	putative homodimer interface [polypeptide binding]; other site
216595013248	PS00445 FGGY family of carbohydrate kinases signature 2.
216595013250	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
216595013251	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
216595013252	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
216595013254	PS00974 Mannitol dehydrogenases signature.
216595013256	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
216595013257	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
216595013258	Walker A/P-loop; other site
216595013259	ATP binding site [chemical binding]; other site
216595013260	Q-loop/lid; other site
216595013261	ABC transporter signature motif; other site
216595013262	Walker B; other site
216595013263	D-loop; other site
216595013264	H-loop/switch region; other site
216595013265	TOBE domain; Region: TOBE; pfam03459
216595013266	TOBE domain; Region: TOBE_2; pfam08402
216595013269	PS00211 ABC transporters family signature.
216595013270	PS00017 ATP/GTP-binding site motif A (P-loop).
216595013271	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
216595013272	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595013273	dimer interface [polypeptide binding]; other site
216595013274	conserved gate region; other site
216595013275	putative PBP binding loops; other site
216595013276	ABC-ATPase subunit interface; other site
216595013278	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595013279	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595013280	dimer interface [polypeptide binding]; other site
216595013281	conserved gate region; other site
216595013282	putative PBP binding loops; other site
216595013283	ABC-ATPase subunit interface; other site
216595013285	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595013286	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
216595013287	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
216595013289	1 probable transmembrane helix predicted for PFLU2745 by TMHMM2.0 at aa 12-34
216595013290	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
216595013291	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595013292	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595013294	PS00041 Bacterial regulatory proteins, araC family signature.
216595013296	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635
216595013297	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595013298	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
216595013299	dimer interface [polypeptide binding]; other site
216595013300	catalytic triad [active]
216595013301	peroxidatic and resolving cysteines [active]
216595013303	PS01265 Tpx family signature.
216595013304	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
216595013305	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
216595013306	HlyD family secretion protein; Region: HlyD_3; pfam13437
216595013307	1 probable transmembrane helix predicted for PFLU2749 by TMHMM2.0 at aa 13-35
216595013309	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
216595013310	Protein export membrane protein; Region: SecD_SecF; cl14618
216595013312	10 probable transmembrane helices predicted for PFLU2750 by TMHMM2.0 at aa 7-29, 334-353, 360-382, 430-452, 459-481, 527-549, 859-881, 901-923, 954-976 and 991-1013
216595013313	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
216595013314	Protein export membrane protein; Region: SecD_SecF; cl14618
216595013316	10 probable transmembrane helices predicted for PFLU2751 by TMHMM2.0 at aa 12-34, 336-353, 360-382, 434-456, 463-485, 529-548, 857-879, 899-921, 952-974 and 989-1011
216595013317	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
216595013319	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595013322	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
216595013323	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
216595013324	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
216595013325	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
216595013326	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216595013327	metal binding site [ion binding]; metal-binding site
216595013328	active site
216595013329	I-site; other site
216595013330	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
216595013331	7 probable transmembrane helices predicted for PFLU2753 by TMHMM2.0 at aa 20-42, 55-77, 92-113, 120-142, 157-179, 192-214 and 234-253
216595013337	short chain dehydrogenase; Provisional; Region: PRK06123
216595013338	classical (c) SDRs; Region: SDR_c; cd05233
216595013339	NAD(P) binding site [chemical binding]; other site
216595013340	active site
216595013342	PS00061 Short-chain dehydrogenases/reductases family signature.
216595013343	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
216595013344	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595013345	DNA-binding site [nucleotide binding]; DNA binding site
216595013346	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216595013347	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595013348	homodimer interface [polypeptide binding]; other site
216595013349	catalytic residue [active]
216595013352	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
216595013353	4Fe-4S binding domain; Region: Fer4_5; pfam12801
216595013354	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
216595013355	PS00017 ATP/GTP-binding site motif A (P-loop).
216595013357	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
216595013358	Protein of unknown function (DUF3203); Region: DUF3203; pfam11462
216595013359	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
216595013360	MgtC family; Region: MgtC; pfam02308
216595013361	5 probable transmembrane helices predicted for PFLU2759 by TMHMM2.0 at aa 28-45, 52-74, 84-102, 114-133 and 138-157
216595013363	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
216595013364	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
216595013365	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
216595013366	active site
216595013367	homodimer interface [polypeptide binding]; other site
216595013368	catalytic site [active]
216595013369	acceptor binding site [chemical binding]; other site
216595013371	PS00019 Actinin-type actin-binding domain signature 1.
216595013372	trehalose synthase; Region: treS_nterm; TIGR02456
216595013373	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
216595013374	active site
216595013375	catalytic site [active]
216595013376	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
216595013377	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
216595013379	PS00697 ATP-dependent DNA ligase AMP-binding site.
216595013381	glycogen branching enzyme; Provisional; Region: PRK05402
216595013382	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
216595013383	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
216595013384	active site
216595013385	catalytic site [active]
216595013386	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
216595013390	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
216595013391	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216595013392	metal binding site [ion binding]; metal-binding site
216595013393	active site
216595013394	I-site; other site
216595013395	5 probable transmembrane helices predicted for PFLU2764 by TMHMM2.0 at aa 43-65, 69-88, 108-127, 155-177 and 184-201
216595013397	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
216595013398	GAF domain; Region: GAF; pfam01590
216595013399	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595013400	dimer interface [polypeptide binding]; other site
216595013401	phosphorylation site [posttranslational modification]
216595013402	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595013403	ATP binding site [chemical binding]; other site
216595013404	Mg2+ binding site [ion binding]; other site
216595013405	G-X-G motif; other site
216595013406	Response regulator receiver domain; Region: Response_reg; pfam00072
216595013407	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595013408	active site
216595013409	phosphorylation site [posttranslational modification]
216595013410	intermolecular recognition site; other site
216595013411	dimerization interface [polypeptide binding]; other site
216595013416	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
216595013417	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
216595013419	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
216595013421	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595013422	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595013423	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
216595013424	putative substrate binding pocket [chemical binding]; other site
216595013425	putative dimerization interface [polypeptide binding]; other site
216595013427	PS00044 Bacterial regulatory proteins, lysR family signature.
216595013429	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
216595013430	Coenzyme A binding pocket [chemical binding]; other site
216595013432	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
216595013433	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216595013435	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
216595013436	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
216595013438	5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128
216595013439	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
216595013440	hinge; other site
216595013441	active site
216595013443	PS00104 EPSP synthase signature 1.
216595013444	hypothetical protein; Provisional; Region: PRK10396
216595013445	Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695
216595013446	1 probable transmembrane helix predicted for PFLU2776 by TMHMM2.0 at aa 7-29
216595013447	enoyl-CoA hydratase; Provisional; Region: PRK06142
216595013448	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
216595013449	substrate binding site [chemical binding]; other site
216595013450	oxyanion hole (OAH) forming residues; other site
216595013451	trimer interface [polypeptide binding]; other site
216595013453	PS00166 Enoyl-CoA hydratase/isomerase signature.
216595013454	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
216595013455	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
216595013456	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
216595013457	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
216595013458	putative NADH binding site [chemical binding]; other site
216595013459	putative active site [active]
216595013460	nudix motif; other site
216595013461	putative metal binding site [ion binding]; other site
216595013465	PS00893 mutT domain signature.
216595013466	hypothetical protein; Provisional; Region: PRK10621
216595013467	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
216595013469	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
216595013470	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
216595013472	S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672
216595013473	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595013474	S-adenosylmethionine binding site [chemical binding]; other site
216595013475	Predicted Fe-S protein [General function prediction only]; Region: COG3313
216595013477	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
216595013478	dimer interface [polypeptide binding]; other site
216595013479	putative radical transfer pathway; other site
216595013480	diiron center [ion binding]; other site
216595013481	tyrosyl radical; other site
216595013483	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
216595013484	YheO-like PAS domain; Region: PAS_6; pfam08348
216595013485	HTH domain; Region: HTH_22; pfam13309
216595013487	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
216595013488	homotrimer interaction site [polypeptide binding]; other site
216595013489	putative active site [active]
216595013491	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
216595013492	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
216595013493	tetramer interface [polypeptide binding]; other site
216595013494	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595013495	catalytic residue [active]
216595013497	PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site.
216595013498	RNA polymerase sigma factor FecI; Provisional; Region: PRK09651
216595013499	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
216595013500	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
216595013501	DNA binding residues [nucleotide binding]
216595013504	fec operon regulator FecR; Reviewed; Region: PRK09774
216595013505	FecR protein; Region: FecR; pfam04773
216595013507	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
216595013508	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
216595013509	Walker A/P-loop; other site
216595013510	ATP binding site [chemical binding]; other site
216595013511	Q-loop/lid; other site
216595013512	ABC transporter signature motif; other site
216595013513	Walker B; other site
216595013514	D-loop; other site
216595013515	H-loop/switch region; other site
216595013517	PS00211 ABC transporters family signature.
216595013518	PS00017 ATP/GTP-binding site motif A (P-loop).
216595013519	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
216595013520	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595013521	dimer interface [polypeptide binding]; other site
216595013522	conserved gate region; other site
216595013523	putative PBP binding loops; other site
216595013524	ABC-ATPase subunit interface; other site
216595013526	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595013527	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
216595013528	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595013529	substrate binding pocket [chemical binding]; other site
216595013530	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
216595013531	membrane-bound complex binding site; other site
216595013533	low G+C content region (36.5%)
216595013534	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
216595013536	putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350
216595013537	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216595013538	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595013539	homodimer interface [polypeptide binding]; other site
216595013540	catalytic residue [active]
216595013542	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
216595013543	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595013544	putative substrate translocation pore; other site
216595013546	Isochorismatase family; Region: Isochorismatase; pfam00857
216595013547	N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This...; Region: CSHase; cd01015
216595013548	catalytic triad [active]
216595013549	substrate binding site [chemical binding]; other site
216595013550	domain interfaces; other site
216595013551	conserved cis-peptide bond; other site
216595013553	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
216595013555	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
216595013556	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
216595013557	catalytic site [active]
216595013559	hypothetical protein; Provisional; Region: PRK06847
216595013560	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
216595013562	low G+C content region (36.8%)
216595013563	MarR family; Region: MarR_2; cl17246
216595013564	Transcriptional regulators [Transcription]; Region: MarR; COG1846
216595013566	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
216595013567	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
216595013568	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
216595013570	PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature.
216595013572	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
216595013573	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
216595013574	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
216595013575	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
216595013576	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
216595013577	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
216595013578	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
216595013579	Cytochrome c; Region: Cytochrom_C; pfam00034
216595013582	PS00030 Eukaryotic putative RNA-binding region RNP-1 signature.
216595013584	PS00190 Cytochrome c family heme-binding site signature.
216595013585	PS00190 Cytochrome c family heme-binding site signature.
216595013587	PS00190 Cytochrome c family heme-binding site signature.
216595013588	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
216595013589	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216595013591	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
216595013592	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
216595013594	PS00462 Gamma-glutamyltranspeptidase signature.
216595013595	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
216595013596	AAA domain; Region: AAA_28; pfam13521
216595013597	PS00017 ATP/GTP-binding site motif A (P-loop).
216595013598	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
216595013600	Cache domain; Region: Cache_2; pfam08269
216595013601	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595013602	dimerization interface [polypeptide binding]; other site
216595013603	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
216595013604	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595013605	dimer interface [polypeptide binding]; other site
216595013606	putative CheW interface [polypeptide binding]; other site
216595013610	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
216595013612	6 probable transmembrane helices predicted for PFLU2809 by TMHMM2.0 at aa 44-63, 83-105, 109-128, 187-205, 220-242 and 249-268
216595013613	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
216595013614	3 probable transmembrane helices predicted for PFLU2810 by TMHMM2.0 at aa 12-29, 33-52 and 96-113
216595013616	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
216595013618	LysR family transcriptional regulator; Provisional; Region: PRK14997
216595013619	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
216595013620	dimerization interface [polypeptide binding]; other site
216595013623	azoreductase; Reviewed; Region: PRK00170
216595013624	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
216595013626	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
216595013627	PS00120 Lipases, serine active site.
216595013628	major facilitator superfamily transporter; Provisional; Region: PRK05122
216595013629	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595013630	putative substrate translocation pore; other site
216595013632	PS00012 Phosphopantetheine attachment site.
216595013634	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
216595013635	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216595013636	Walker A/P-loop; other site
216595013637	ATP binding site [chemical binding]; other site
216595013638	Q-loop/lid; other site
216595013639	ABC transporter signature motif; other site
216595013640	Walker B; other site
216595013641	D-loop; other site
216595013642	H-loop/switch region; other site
216595013643	ABC transporter; Region: ABC_tran_2; pfam12848
216595013644	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
216595013646	PS00017 ATP/GTP-binding site motif A (P-loop).
216595013648	PS00017 ATP/GTP-binding site motif A (P-loop).
216595013649	Prophage 3
216595013650	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
216595013651	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
216595013652	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
216595013653	active site
216595013654	DNA binding site [nucleotide binding]
216595013655	Int/Topo IB signature motif; other site
216595013657	NUMOD4 motif; Region: NUMOD4; pfam07463
216595013658	HNH endonuclease; Region: HNH_3; pfam13392
216595013659	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
216595013661	Domain of unknown function (DUF4406); Region: DUF4406; pfam14359
216595013662	3 probable transmembrane helices predicted for PFLU2828 by TMHMM2.0 at aa 20-37, 52-71 and 99-121
216595013663	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
216595013664	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
216595013665	cofactor binding site; other site
216595013666	DNA binding site [nucleotide binding]
216595013667	substrate interaction site [chemical binding]; other site
216595013669	4 probable transmembrane helices predicted for PFLU2830 by TMHMM2.0 at aa 20-42, 108-130, 140-159 and 207-226
216595013670	YqaJ-like viral recombinase domain; Region: YqaJ; cl09232
216595013671	RecT family; Region: RecT; cl04285
216595013673	PS00017 ATP/GTP-binding site motif A (P-loop).
216595013674	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
216595013675	Protein of unknown function (DUF1654); Region: DUF1654; pfam07867
216595013677	3 probable transmembrane helices predicted for PFLU2844 by TMHMM2.0 at aa 79-101, 116-138 and 159-181
216595013678	Domain of unknown function (DUF4411); Region: DUF4411; pfam14367
216595013679	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
216595013680	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216595013681	non-specific DNA binding site [nucleotide binding]; other site
216595013682	sequence-specific DNA binding site [nucleotide binding]; other site
216595013683	salt bridge; other site
216595013684	Domain of unknown function (DUF955); Region: DUF955; cl01076
216595013686	PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.
216595013688	1 probable transmembrane helix predicted for PFLU2847 by TMHMM2.0 at aa 27-44
216595013689	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
216595013690	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216595013691	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
216595013692	non-specific DNA binding site [nucleotide binding]; other site
216595013693	salt bridge; other site
216595013694	sequence-specific DNA binding site [nucleotide binding]; other site
216595013695	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
216595013696	Catalytic site [active]
216595013699	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216595013700	non-specific DNA binding site [nucleotide binding]; other site
216595013701	salt bridge; other site
216595013702	sequence-specific DNA binding site [nucleotide binding]; other site
216595013704	NAD-dependent deacetylase; Provisional; Region: PRK14138
216595013705	Bacteriophage Lambda NinG protein; Region: NinG; pfam05766
216595013707	5 probable transmembrane helices predicted for PFLU2857 by TMHMM2.0 at aa 42-64, 93-115, 122-139, 144-161 and 191-213
216595013708	Mu-like prophage protein Com; Region: Mu-like_Com; pfam10122
216595013709	1 probable transmembrane helix predicted for PFLU2860 by TMHMM2.0 at aa 10-32
216595013710	1 probable transmembrane helix predicted for PFLU2861 by TMHMM2.0 at aa 20-42
216595013711	large terminase protein; Provisional; Region: 17; PHA02533
216595013712	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
216595013713	Domain of unknown function (DUF4055); Region: DUF4055; pfam13264
216595013714	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
216595013715	LEM-like domain of lamina-associated polypeptide 2 (LAP2) and similar proteins; Region: LEM_like; cd12935
216595013716	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
216595013717	Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554
216595013718	Phage tail protein; Region: Phage_tail_3; pfam08813
216595013720	Domain of unknown function (DUF1789); Region: DUF1789; pfam08748
216595013722	Phage related hypothetical protein (DUF1799); Region: DUF1799; pfam08809
216595013724	Prophage tail length tape measure protein; Region: TMP_2; pfam06791
216595013725	phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541
216595013726	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718
216595013728	Phage minor tail protein; Region: Phage_min_tail; pfam05939
216595013730	Phage-related protein [Function unknown]; Region: gp18; COG4672
216595013732	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073
216595013733	MPN+ (JAMM) motif; other site
216595013734	Zinc-binding site [ion binding]; other site
216595013735	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
216595013736	NlpC/P60 family; Region: NLPC_P60; cl17555
216595013738	Uncharacterized conserved protein [Function unknown]; Region: COG4748
216595013739	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
216595013741	1 probable transmembrane helix predicted for PFLU2890 by TMHMM2.0 at aa 20-39
216595013742	Phage-related protein, tail component [Function unknown]; Region: COG4723
216595013744	1 probable transmembrane helix predicted for PFLU2891 by TMHMM2.0 at aa 103-125
216595013745	Phage-related protein, tail component [Function unknown]; Region: COG4733
216595013746	Putative phage tail protein; Region: Phage-tail_3; pfam13550
216595013747	Tissue factor; Region: Tissue_fac; pfam01108
216595013748	Domain of unknown function (DUF1983); Region: DUF1983; pfam09327
216595013751	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
216595013753	Bacteriophage lysis protein; Region: Phage_lysis; pfam03245
216595013754	1 probable transmembrane helix predicted for PFLU2897 by TMHMM2.0 at aa 7-26
216595013755	Uncharacterized ACR, COG2135; Region: DUF159; cl03646
216595013757	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
216595013758	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
216595013759	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
216595013765	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595013766	Major Facilitator Superfamily; Region: MFS_1; pfam07690
216595013768	PS00216 Sugar transport proteins signature 1.
216595013769	Methyltransferase domain; Region: Methyltransf_31; pfam13847
216595013770	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595013771	S-adenosylmethionine binding site [chemical binding]; other site
216595013773	Planctomycetes uncharacterized domain TIGR03067; Region: Planc_TIGR03067
216595013774	Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765
216595013775	Chain length determinant protein; Region: Wzz; pfam02706
216595013776	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
216595013778	2 probable transmembrane helices predicted for PFLU2909 by TMHMM2.0 at aa 31-50 and 395-414
216595013779	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
216595013781	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
216595013782	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
216595013783	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
216595013784	active site
216595013785	DNA binding site [nucleotide binding]
216595013786	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
216595013787	DNA binding site [nucleotide binding]
216595013788	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
216595013789	nucleotide binding site [chemical binding]; other site
216595013793	PS00697 ATP-dependent DNA ligase AMP-binding site.
216595013794	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
216595013795	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
216595013796	putative DNA binding site [nucleotide binding]; other site
216595013797	putative homodimer interface [polypeptide binding]; other site
216595013799	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
216595013800	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
216595013802	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
216595013804	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
216595013805	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216595013807	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
216595013808	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
216595013809	domain interface [polypeptide binding]; other site
216595013810	putative active site [active]
216595013811	catalytic site [active]
216595013812	Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136
216595013813	domain interface [polypeptide binding]; other site
216595013814	putative active site [active]
216595013815	catalytic site [active]
216595013818	Imelysin; Region: Peptidase_M75; pfam09375
216595013820	1 probable transmembrane helix predicted for PFLU2918 by TMHMM2.0 at aa 7-29
216595013821	Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
216595013822	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
216595013824	1 probable transmembrane helix predicted for PFLU2919 by TMHMM2.0 at aa 21-43
216595013825	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
216595013826	Imelysin; Region: Peptidase_M75; pfam09375
216595013828	1 probable transmembrane helix predicted for PFLU2920 by TMHMM2.0 at aa 15-37
216595013829	Iron permease FTR1 family; Region: FTR1; cl00475
216595013831	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
216595013832	HSP70 interaction site [polypeptide binding]; other site
216595013834	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
216595013835	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
216595013836	SurA N-terminal domain; Region: SurA_N; pfam09312
216595013837	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595013839	low G+C content region (39.42%)
216595013840	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595013841	putative substrate translocation pore; other site
216595013842	Major Facilitator Superfamily; Region: MFS_1; pfam07690
216595013844	PS00216 Sugar transport proteins signature 1.
216595013845	ThiF family; Region: ThiF; pfam00899
216595013846	ATP binding site [chemical binding]; other site
216595013847	substrate interface [chemical binding]; other site
216595013849	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
216595013850	Walker A/P-loop; other site
216595013851	ATP binding site [chemical binding]; other site
216595013852	Q-loop/lid; other site
216595013853	ABC transporter signature motif; other site
216595013854	Walker B; other site
216595013855	D-loop; other site
216595013856	H-loop/switch region; other site
216595013857	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
216595013859	PS00017 ATP/GTP-binding site motif A (P-loop).
216595013860	Cupin-like domain; Region: Cupin_8; pfam13621
216595013862	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
216595013865	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595013866	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
216595013868	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
216595013869	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
216595013870	HlyD family secretion protein; Region: HlyD_3; pfam13437
216595013872	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595013873	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
216595013875	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595013876	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595013877	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
216595013878	putative substrate binding pocket [chemical binding]; other site
216595013879	dimerization interface [polypeptide binding]; other site
216595013882	PS00044 Bacterial regulatory proteins, lysR family signature.
216595013883	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
216595013885	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
216595013886	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
216595013887	1 probable transmembrane helix predicted for PFLU2935 by TMHMM2.0 at aa 7-29
216595013889	Response regulator receiver domain; Region: Response_reg; pfam00072
216595013890	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595013891	active site
216595013892	phosphorylation site [posttranslational modification]
216595013893	intermolecular recognition site; other site
216595013894	dimerization interface [polypeptide binding]; other site
216595013896	CHASE3 domain; Region: CHASE3; pfam05227
216595013897	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595013898	PAS domain; Region: PAS_9; pfam13426
216595013899	putative active site [active]
216595013900	heme pocket [chemical binding]; other site
216595013901	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
216595013902	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595013903	dimer interface [polypeptide binding]; other site
216595013904	phosphorylation site [posttranslational modification]
216595013905	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595013906	ATP binding site [chemical binding]; other site
216595013907	Mg2+ binding site [ion binding]; other site
216595013908	G-X-G motif; other site
216595013909	Response regulator receiver domain; Region: Response_reg; pfam00072
216595013910	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595013911	active site
216595013912	phosphorylation site [posttranslational modification]
216595013913	intermolecular recognition site; other site
216595013914	dimerization interface [polypeptide binding]; other site
216595013921	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
216595013922	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595013923	active site
216595013924	phosphorylation site [posttranslational modification]
216595013925	intermolecular recognition site; other site
216595013926	dimerization interface [polypeptide binding]; other site
216595013927	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216595013928	DNA binding residues [nucleotide binding]
216595013929	dimerization interface [polypeptide binding]; other site
216595013932	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
216595013933	Histidine kinase; Region: HisKA_3; pfam07730
216595013934	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595013935	ATP binding site [chemical binding]; other site
216595013936	Mg2+ binding site [ion binding]; other site
216595013937	G-X-G motif; other site
216595013941	SnoaL-like domain; Region: SnoaL_3; pfam13474
216595013942	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
216595013944	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
216595013945	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216595013946	N-terminal plug; other site
216595013947	ligand-binding site [chemical binding]; other site
216595013950	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
216595013951	1 probable transmembrane helix predicted for PFLU2942 by TMHMM2.0 at aa 7-29
216595013952	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334
216595013953	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
216595013954	putative ligand binding site [chemical binding]; other site
216595013955	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
216595013956	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
216595013957	Walker A/P-loop; other site
216595013958	ATP binding site [chemical binding]; other site
216595013959	Q-loop/lid; other site
216595013960	ABC transporter signature motif; other site
216595013961	Walker B; other site
216595013962	D-loop; other site
216595013963	H-loop/switch region; other site
216595013964	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
216595013965	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
216595013966	Walker A/P-loop; other site
216595013967	ATP binding site [chemical binding]; other site
216595013968	Q-loop/lid; other site
216595013969	ABC transporter signature motif; other site
216595013970	Walker B; other site
216595013971	D-loop; other site
216595013972	H-loop/switch region; other site
216595013973	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
216595013976	PS00211 ABC transporters family signature.
216595013977	PS00017 ATP/GTP-binding site motif A (P-loop).
216595013980	PS00211 ABC transporters family signature.
216595013981	PS00017 ATP/GTP-binding site motif A (P-loop).
216595013982	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
216595013983	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595013984	dimer interface [polypeptide binding]; other site
216595013985	ABC-ATPase subunit interface; other site
216595013986	putative PBP binding loops; other site
216595013988	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595013989	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
216595013990	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595013991	dimer interface [polypeptide binding]; other site
216595013992	conserved gate region; other site
216595013993	putative PBP binding loops; other site
216595013994	ABC-ATPase subunit interface; other site
216595013996	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492
216595013997	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
216595013999	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
216595014000	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216595014001	N-terminal plug; other site
216595014002	ligand-binding site [chemical binding]; other site
216595014004	PS00092 N-6 Adenine-specific DNA methylases signature.
216595014006	very low G+C content region (26.89%)
216595014007	Protein of unknown function (DUF2388); Region: DUF2388; cl09731
216595014008	Protein of unknown function (DUF2388); Region: DUF2388; pfam09498
216595014009	1 probable transmembrane helix predicted for PFLU2950 by TMHMM2.0 at aa 28-50
216595014010	DinB family; Region: DinB; cl17821
216595014012	Protein of unknown function (DUF533); Region: DUF533; pfam04391
216595014013	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
216595014014	putative metal binding site [ion binding]; other site
216595014016	1 probable transmembrane helix predicted for PFLU2955 by TMHMM2.0 at aa 43-60
216595014017	Protein of unknown function (DUF2493); Region: DUF2493; pfam10686
216595014018	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
216595014019	magnesium-transporting ATPase; Provisional; Region: PRK15122
216595014020	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
216595014021	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
216595014022	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
216595014023	Soluble P-type ATPase [General function prediction only]; Region: COG4087
216595014024	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
216595014026	PS00154 E1-E2 ATPases phosphorylation site.
216595014029	low G+C content region (46.28%)
216595014030	low G+C content region (41.48%)
216595014031	LysE type translocator; Region: LysE; pfam01810
216595014033	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
216595014034	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595014035	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
216595014036	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595014040	Low molecular weight phosphatase family; Region: LMWPc; cl00105
216595014041	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
216595014042	active site
216595014044	arsenical pump membrane protein; Provisional; Region: PRK15445
216595014045	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
216595014046	transmembrane helices; other site
216595014048	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595014049	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
216595014050	5 probable transmembrane helices predicted for PFLU2963 by TMHMM2.0 at aa 13-35, 50-72, 131-153, 163-180 and 187-209
216595014052	PS00017 ATP/GTP-binding site motif A (P-loop).
216595014053	Predicted membrane protein [Function unknown]; Region: COG4392
216595014054	4 probable transmembrane helices predicted for PFLU2964 by TMHMM2.0 at aa 2-21, 36-55, 62-81 and 85-102
216595014056	Predicted membrane protein [Function unknown]; Region: COG3619
216595014058	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
216595014059	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216595014060	Walker A/P-loop; other site
216595014061	ATP binding site [chemical binding]; other site
216595014062	Q-loop/lid; other site
216595014063	ABC transporter signature motif; other site
216595014064	Walker B; other site
216595014065	D-loop; other site
216595014066	H-loop/switch region; other site
216595014067	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
216595014068	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
216595014069	G1 box; other site
216595014070	GTP/Mg2+ binding site [chemical binding]; other site
216595014072	PS00017 ATP/GTP-binding site motif A (P-loop).
216595014074	PS00211 ABC transporters family signature.
216595014075	PS00017 ATP/GTP-binding site motif A (P-loop).
216595014076	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
216595014077	DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659
216595014078	active site
216595014079	DNA binding site [nucleotide binding]
216595014080	Int/Topo IB signature motif; other site
216595014081	catalytic residues [active]
216595014083	ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148
216595014084	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216595014085	Walker A/P-loop; other site
216595014086	ATP binding site [chemical binding]; other site
216595014087	Q-loop/lid; other site
216595014088	ABC transporter signature motif; other site
216595014089	Walker B; other site
216595014090	D-loop; other site
216595014091	H-loop/switch region; other site
216595014092	TOBE domain; Region: TOBE; cl01440
216595014095	PS00211 ABC transporters family signature.
216595014096	PS00017 ATP/GTP-binding site motif A (P-loop).
216595014097	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
216595014098	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595014099	dimer interface [polypeptide binding]; other site
216595014100	conserved gate region; other site
216595014101	putative PBP binding loops; other site
216595014102	ABC-ATPase subunit interface; other site
216595014104	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
216595014105	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
216595014107	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
216595014108	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
216595014109	FMN binding site [chemical binding]; other site
216595014110	substrate binding site [chemical binding]; other site
216595014111	putative catalytic residue [active]
216595014113	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
216595014115	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
216595014116	CGNR zinc finger; Region: zf-CGNR; pfam11706
216595014118	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
216595014119	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
216595014120	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595014121	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
216595014122	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
216595014123	DNA binding site [nucleotide binding]
216595014124	active site
216595014126	PS00374 Methylated-DNA--protein-cysteine methyltransferase active site.
216595014129	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
216595014131	Domain of unknown function (DUF1883); Region: DUF1883; pfam08980
216595014133	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595014134	Cytochrome c; Region: Cytochrom_C; cl11414
216595014135	Cytochrome c; Region: Cytochrom_C; cl11414
216595014136	PS00190 Cytochrome c family heme-binding site signature.
216595014138	PS00190 Cytochrome c family heme-binding site signature.
216595014139	Cytochrome c [Energy production and conversion]; Region: COG3258
216595014140	Cytochrome c; Region: Cytochrom_C; pfam00034
216595014141	PS00190 Cytochrome c family heme-binding site signature.
216595014143	PS00190 Cytochrome c family heme-binding site signature.
216595014144	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595014145	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
216595014146	active site
216595014147	tetramer interface; other site
216595014149	glutathione reductase; Validated; Region: PRK06116
216595014150	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
216595014151	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
216595014152	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
216595014154	PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site.
216595014157	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
216595014158	low G+C content region (39.59%)
216595014159	Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799
216595014160	DNA binding site [nucleotide binding]
216595014161	dimer interface [polypeptide binding]; other site
216595014162	active site
216595014163	Int/Topo IB signature motif; other site
216595014165	peroxiredoxin; Region: AhpC; TIGR03137
216595014166	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
216595014167	dimer interface [polypeptide binding]; other site
216595014168	decamer (pentamer of dimers) interface [polypeptide binding]; other site
216595014169	catalytic triad [active]
216595014170	peroxidatic and resolving cysteines [active]
216595014172	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
216595014173	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
216595014174	catalytic residue [active]
216595014175	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
216595014176	catalytic residues [active]
216595014177	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
216595014178	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
216595014180	PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site.
216595014182	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
216595014183	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
216595014184	dimer interface [polypeptide binding]; other site
216595014185	active site
216595014186	metal binding site [ion binding]; metal-binding site
216595014187	glutathione binding site [chemical binding]; other site
216595014189	PS00935 Glyoxalase I signature 2.
216595014190	PS00934 Glyoxalase I signature 1.
216595014191	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
216595014192	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
216595014194	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595014195	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595014196	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
216595014197	dimerization interface [polypeptide binding]; other site
216595014200	PS00044 Bacterial regulatory proteins, lysR family signature.
216595014201	EamA-like transporter family; Region: EamA; pfam00892
216595014202	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
216595014203	EamA-like transporter family; Region: EamA; pfam00892
216595014204	10 probable transmembrane helices predicted for PFLU2996 by TMHMM2.0 at aa 33-55, 65-87, 99-117, 122-144, 151-169, 179-201, 214-236, 246-268, 281-298 and 302-321
216595014207	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
216595014208	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
216595014209	dimer interface [polypeptide binding]; other site
216595014210	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
216595014211	active site
216595014212	Fe binding site [ion binding]; other site
216595014214	Predicted permeases [General function prediction only]; Region: RarD; COG2962
216595014215	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
216595014216	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
216595014217	active site
216595014218	catalytic tetrad [active]
216595014220	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595014221	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595014222	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
216595014223	putative effector binding pocket; other site
216595014224	dimerization interface [polypeptide binding]; other site
216595014227	PS00044 Bacterial regulatory proteins, lysR family signature.
216595014228	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216595014229	NAD(P) binding site [chemical binding]; other site
216595014230	active site
216595014232	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
216595014233	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595014234	putative substrate translocation pore; other site
216595014236	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
216595014237	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
216595014238	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
216595014241	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
216595014243	PS00017 ATP/GTP-binding site motif A (P-loop).
216595014244	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996
216595014245	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
216595014246	active site
216595014247	Zn binding site [ion binding]; other site
216595014250	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
216595014251	YOP proteins translocation protein K (YscK); Region: YscK; pfam06578
216595014252	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
216595014253	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216595014254	DNA binding residues [nucleotide binding]
216595014255	dimerization interface [polypeptide binding]; other site
216595014257	putative acetyltransferase YhhY; Provisional; Region: PRK10140
216595014258	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216595014259	Coenzyme A binding pocket [chemical binding]; other site
216595014261	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
216595014262	aspartate racemase; Region: asp_race; TIGR00035
216595014264	PS00924 Aspartate and glutamate racemases signature 2.
216595014265	PS00923 Aspartate and glutamate racemases signature 1.
216595014266	Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545
216595014267	cbb3-type cytochrome c oxidase subunit I; Provisional; Region: PRK14488
216595014268	Low-spin heme binding site [chemical binding]; other site
216595014269	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
216595014270	D-pathway; other site
216595014271	Putative water exit pathway; other site
216595014272	Binuclear center (active site) [active]
216595014273	K-pathway; other site
216595014274	Putative proton exit pathway; other site
216595014276	PS00077 Heme-copper oxidase catalytic subunit, copper B binding region signature.
216595014277	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
216595014278	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595014279	Uncharacterized conserved protein [Function unknown]; Region: COG5361
216595014280	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
216595014281	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
216595014284	Response regulator receiver domain; Region: Response_reg; pfam00072
216595014285	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595014286	active site
216595014287	phosphorylation site [posttranslational modification]
216595014288	intermolecular recognition site; other site
216595014289	dimerization interface [polypeptide binding]; other site
216595014291	CHASE3 domain; Region: CHASE3; pfam05227
216595014292	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
216595014293	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
216595014294	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595014295	dimer interface [polypeptide binding]; other site
216595014296	phosphorylation site [posttranslational modification]
216595014297	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595014298	ATP binding site [chemical binding]; other site
216595014299	Mg2+ binding site [ion binding]; other site
216595014300	G-X-G motif; other site
216595014301	Response regulator receiver domain; Region: Response_reg; pfam00072
216595014302	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595014303	active site
216595014304	phosphorylation site [posttranslational modification]
216595014305	intermolecular recognition site; other site
216595014306	dimerization interface [polypeptide binding]; other site
216595014307	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
216595014308	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595014309	active site
216595014310	phosphorylation site [posttranslational modification]
216595014311	intermolecular recognition site; other site
216595014312	Response regulator receiver domain; Region: Response_reg; pfam00072
216595014313	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595014314	active site
216595014315	phosphorylation site [posttranslational modification]
216595014316	intermolecular recognition site; other site
216595014317	dimerization interface [polypeptide binding]; other site
216595014318	2 probable transmembrane helices predicted for PFLU3017 by TMHMM2.0 at aa 41-63 and 202-224
216595014320	PS00215 Mitochondrial energy transfer proteins signature.
216595014325	PS00290 Immunoglobulins and major histocompatibility complex proteins signature.
216595014328	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
216595014329	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
216595014330	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
216595014333	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
216595014334	CheB methylesterase; Region: CheB_methylest; pfam01339
216595014335	1 probable transmembrane helix predicted for PFLU3019 by TMHMM2.0 at aa 13-35
216595014337	ggaaccnnnnnnnnnnnnnnnnccacnna
216595014338	Response regulator receiver domain; Region: Response_reg; pfam00072
216595014339	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595014340	active site
216595014341	phosphorylation site [posttranslational modification]
216595014342	intermolecular recognition site; other site
216595014343	dimerization interface [polypeptide binding]; other site
216595014344	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
216595014345	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595014346	dimer interface [polypeptide binding]; other site
216595014347	phosphorylation site [posttranslational modification]
216595014348	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595014349	ATP binding site [chemical binding]; other site
216595014350	Mg2+ binding site [ion binding]; other site
216595014351	G-X-G motif; other site
216595014355	Response regulator receiver domain; Region: Response_reg; pfam00072
216595014356	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595014357	active site
216595014358	phosphorylation site [posttranslational modification]
216595014359	intermolecular recognition site; other site
216595014360	dimerization interface [polypeptide binding]; other site
216595014362	Yersinia/Haemophilus virulence surface antigen; Region: Peptidase_C58; cl04145
216595014363	PS00136 Serine proteases, subtilase family, aspartic acid active site.
216595014364	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595014365	dimer interface [polypeptide binding]; other site
216595014366	phosphorylation site [posttranslational modification]
216595014367	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595014368	ATP binding site [chemical binding]; other site
216595014369	Mg2+ binding site [ion binding]; other site
216595014370	G-X-G motif; other site
216595014371	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
216595014372	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595014373	active site
216595014374	phosphorylation site [posttranslational modification]
216595014375	intermolecular recognition site; other site
216595014376	dimerization interface [polypeptide binding]; other site
216595014380	circadian clock protein KaiC; Reviewed; Region: PRK09302
216595014381	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
216595014382	Walker A motif; other site
216595014383	ATP binding site [chemical binding]; other site
216595014384	Walker B motif; other site
216595014385	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
216595014386	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
216595014387	Walker A motif; other site
216595014388	Walker A motif; other site
216595014389	ATP binding site [chemical binding]; other site
216595014390	Walker B motif; other site
216595014392	PS00017 ATP/GTP-binding site motif A (P-loop).
216595014394	PS00017 ATP/GTP-binding site motif A (P-loop).
216595014395	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
216595014396	TPR motif; other site
216595014397	binding surface
216595014401	1 probable transmembrane helix predicted for PFLU3025 by TMHMM2.0 at aa 7-26
216595014402	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
216595014404	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
216595014405	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216595014406	NAD(P) binding site [chemical binding]; other site
216595014407	active site
216595014409	1 probable transmembrane helix predicted for PFLU3027 by TMHMM2.0 at aa 7-29
216595014410	PS00061 Short-chain dehydrogenases/reductases family signature.
216595014411	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
216595014412	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
216595014413	dimer interface [polypeptide binding]; other site
216595014414	active site
216595014417	PS00099 Thiolases active site.
216595014418	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
216595014419	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
216595014420	active site
216595014423	PS00072 Acyl-CoA dehydrogenases signature 1.
216595014425	PS00073 Acyl-CoA dehydrogenases signature 2.
216595014426	enoyl-CoA hydratase; Provisional; Region: PRK05862
216595014427	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
216595014428	substrate binding site [chemical binding]; other site
216595014429	oxyanion hole (OAH) forming residues; other site
216595014430	trimer interface [polypeptide binding]; other site
216595014432	PS00166 Enoyl-CoA hydratase/isomerase signature.
216595014433	PS00017 ATP/GTP-binding site motif A (P-loop).
216595014434	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
216595014435	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
216595014436	active site
216595014438	PS00073 Acyl-CoA dehydrogenases signature 2.
216595014441	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
216595014442	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
216595014443	substrate binding site [chemical binding]; other site
216595014444	oxyanion hole (OAH) forming residues; other site
216595014445	trimer interface [polypeptide binding]; other site
216595014446	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
216595014448	HPP family; Region: HPP; pfam04982
216595014450	Protein of unknown function (DUF770); Region: DUF770; cl01402
216595014451	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
216595014453	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
216595014454	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
216595014455	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
216595014456	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
216595014460	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
216595014461	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051
216595014463	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595014464	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
216595014465	4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279
216595014467	4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394
216595014468	Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939
216595014469	putative active site [active]
216595014470	putative catalytic site [active]
216595014471	putative Zn binding site [ion binding]; other site
216595014473	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
216595014474	bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125
216595014475	active site
216595014476	substrate binding site [chemical binding]; other site
216595014477	cosubstrate binding site; other site
216595014478	catalytic site [active]
216595014479	C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702
216595014480	active site
216595014481	hexamer interface [polypeptide binding]; other site
216595014482	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
216595014483	NAD binding site [chemical binding]; other site
216595014484	substrate binding site [chemical binding]; other site
216595014485	active site
216595014489	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
216595014490	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
216595014491	Ligand binding site; other site
216595014492	Putative Catalytic site; other site
216595014493	DXD motif; other site
216595014495	1 probable transmembrane helix predicted for PFLU3043 by TMHMM2.0 at aa 13-32
216595014496	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
216595014497	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
216595014498	active site
216595014499	DNA binding site [nucleotide binding]
216595014500	Int/Topo IB signature motif; other site
216595014503	short chain dehydrogenase; Provisional; Region: PRK06701
216595014504	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
216595014505	NAD binding site [chemical binding]; other site
216595014506	metal binding site [ion binding]; metal-binding site
216595014507	active site
216595014509	PS00061 Short-chain dehydrogenases/reductases family signature.
216595014510	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595014511	putative substrate translocation pore; other site
216595014513	PS00017 ATP/GTP-binding site motif A (P-loop).
216595014514	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
216595014515	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
216595014516	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
216595014517	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595014518	dimer interface [polypeptide binding]; other site
216595014519	putative CheW interface [polypeptide binding]; other site
216595014520	2 probable transmembrane helices predicted for PFLU3047 by TMHMM2.0 at aa 5-27 and 183-205
216595014523	Predicted transcriptional regulators [Transcription]; Region: COG1733
216595014524	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
216595014526	short chain dehydrogenase; Provisional; Region: PRK06500
216595014527	classical (c) SDRs; Region: SDR_c; cd05233
216595014528	NAD(P) binding site [chemical binding]; other site
216595014529	active site
216595014531	PS00061 Short-chain dehydrogenases/reductases family signature.
216595014532	low G+C content region (34.5%)
216595014533	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595014534	PS00017 ATP/GTP-binding site motif A (P-loop).
216595014535	Predicted transcriptional regulator [Transcription]; Region: COG2378
216595014536	WYL domain; Region: WYL; pfam13280
216595014537	low G+C content region (37.94%)
216595014538	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
216595014539	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595014540	dimerization interface [polypeptide binding]; other site
216595014541	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
216595014542	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595014543	dimer interface [polypeptide binding]; other site
216595014544	putative CheW interface [polypeptide binding]; other site
216595014548	outer membrane porin, OprD family; Region: OprD; pfam03573
216595014550	PS00225 Crystallins beta and gamma 'Greek key' motif signature.
216595014551	PS00017 ATP/GTP-binding site motif A (P-loop).
216595014552	H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620
216595014553	Citrate transporter; Region: CitMHS; pfam03600
216595014555	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
216595014556	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
216595014558	PS00714 Sodium:dicarboxylate symporter family signature 2.
216595014559	PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature.
216595014560	PS00713 Sodium:dicarboxylate symporter family signature 1.
216595014561	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828
216595014562	Translocon-associated protein (TRAP), alpha subunit; Region: TRAP_alpha; pfam03896
216595014564	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595014565	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595014566	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
216595014567	putative dimerization interface [polypeptide binding]; other site
216595014569	PS00044 Bacterial regulatory proteins, lysR family signature.
216595014571	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
216595014572	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
216595014574	PS00181 Glutamine synthetase putative ATP-binding region signature.
216595014575	aminotransferase; Validated; Region: PRK07046
216595014576	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
216595014577	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
216595014578	catalytic residue [active]
216595014580	low G+C content region (35.83%)
216595014581	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
216595014582	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216595014583	NAD(P) binding site [chemical binding]; other site
216595014584	active site
216595014586	very low G+C content region (27.84%)
216595014587	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595014588	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595014589	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
216595014590	dimerization interface [polypeptide binding]; other site
216595014593	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
216595014594	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
216595014596	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
216595014597	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
216595014599	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
216595014600	homotrimer interaction site [polypeptide binding]; other site
216595014601	putative active site [active]
216595014603	ornithine cyclodeaminase; Validated; Region: PRK06199
216595014604	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
216595014606	PS00017 ATP/GTP-binding site motif A (P-loop).
216595014607	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
216595014608	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595014610	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
216595014611	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595014612	active site
216595014613	phosphorylation site [posttranslational modification]
216595014614	intermolecular recognition site; other site
216595014615	dimerization interface [polypeptide binding]; other site
216595014616	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216595014617	DNA binding site [nucleotide binding]
216595014620	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
216595014621	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595014622	dimerization interface [polypeptide binding]; other site
216595014623	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595014624	dimer interface [polypeptide binding]; other site
216595014625	phosphorylation site [posttranslational modification]
216595014626	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595014627	ATP binding site [chemical binding]; other site
216595014628	Mg2+ binding site [ion binding]; other site
216595014629	G-X-G motif; other site
216595014630	2 probable transmembrane helices predicted for PFLU3075 by TMHMM2.0 at aa 13-35 and 55-77
216595014634	1 probable transmembrane helix predicted for PFLU3077 by TMHMM2.0 at aa 44-66
216595014635	ABC transporter transmembrane region; Region: ABC_membrane_3; pfam13748
216595014636	5 probable transmembrane helices predicted for PFLU3078 by TMHMM2.0 at aa 36-58, 73-92, 140-159, 163-182 and 231-253
216595014637	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
216595014638	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595014640	PS00041 Bacterial regulatory proteins, araC family signature.
216595014642	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
216595014644	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
216595014645	hypothetical protein; Provisional; Region: PRK07236
216595014646	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
216595014647	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
216595014649	Amino acid synthesis; Region: AA_synth; pfam06684
216595014651	The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6,  and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348
216595014652	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
216595014653	putative active site [active]
216595014654	putative metal binding site [ion binding]; other site
216595014656	PS00082 Extradiol ring-cleavage dioxygenases signature.
216595014657	PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.
216595014658	Ycf48-like protein; Provisional; Region: PRK13684
216595014659	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
216595014666	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
216595014667	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216595014668	NAD(P) binding site [chemical binding]; other site
216595014669	active site
216595014671	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
216595014672	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
216595014673	NAD(P) binding site [chemical binding]; other site
216595014674	catalytic residues [active]
216595014676	PS00070 Aldehyde dehydrogenases cysteine active site.
216595014677	PS00687 Aldehyde dehydrogenases glutamic acid active site.
216595014678	hypothetical protein; Validated; Region: PRK07586
216595014679	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
216595014680	PYR/PP interface [polypeptide binding]; other site
216595014681	dimer interface [polypeptide binding]; other site
216595014682	TPP binding site [chemical binding]; other site
216595014683	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
216595014684	TPP-binding site [chemical binding]; other site
216595014685	dimer interface [polypeptide binding]; other site
216595014689	Transcriptional regulator [Transcription]; Region: IclR; COG1414
216595014690	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
216595014691	Bacterial transcriptional regulator; Region: IclR; pfam01614
216595014694	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
216595014695	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
216595014696	Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106
216595014697	NAD(P) binding site [chemical binding]; other site
216595014698	catalytic residues [active]
216595014700	PS00070 Aldehyde dehydrogenases cysteine active site.
216595014701	PS00687 Aldehyde dehydrogenases glutamic acid active site.
216595014702	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
216595014704	Cache domain; Region: Cache_1; pfam02743
216595014705	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595014706	dimerization interface [polypeptide binding]; other site
216595014707	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
216595014708	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595014709	dimer interface [polypeptide binding]; other site
216595014710	putative CheW interface [polypeptide binding]; other site
216595014711	2 probable transmembrane helices predicted for PFLU3092 by TMHMM2.0 at aa 10-32 and 330-352
216595014715	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
216595014716	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595014717	putative substrate translocation pore; other site
216595014718	14 probable transmembrane helices predicted for PFLU3093 by TMHMM2.0 at aa 7-26, 46-68, 75-94, 104-126, 135-157, 162-184, 197-214, 224-242, 262-284, 299-321, 328-347, 352-374, 395-417 and 464-486
216595014720	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
216595014722	Helix-turn-helix domain; Region: HTH_18; pfam12833
216595014723	PS00041 Bacterial regulatory proteins, araC family signature.
216595014724	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
216595014725	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
216595014726	inhibitor-cofactor binding pocket; inhibition site
216595014727	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595014728	catalytic residue [active]
216595014730	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
216595014731	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
216595014732	NAD(P) binding site [chemical binding]; other site
216595014733	catalytic residues [active]
216595014735	PS00017 ATP/GTP-binding site motif A (P-loop).
216595014736	PS00687 Aldehyde dehydrogenases glutamic acid active site.
216595014737	PS00070 Aldehyde dehydrogenases cysteine active site.
216595014738	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
216595014740	4 probable transmembrane helices predicted for PFLU3098 by TMHMM2.0 at aa 30-47, 62-84, 111-133 and 157-179
216595014741	DKNYY family; Region: DKNYY; pfam13644
216595014742	DKNYY family; Region: DKNYY; pfam13644
216595014743	DKNYY family; Region: DKNYY; pfam13644
216595014744	Cupin domain; Region: Cupin_2; pfam07883
216595014745	Peptidase family M48; Region: Peptidase_M48; cl12018
216595014747	PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.
216595014748	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
216595014749	Part of AAA domain; Region: AAA_19; pfam13245
216595014750	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
216595014751	AAA domain; Region: AAA_12; pfam13087
216595014752	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
216595014753	PS00017 ATP/GTP-binding site motif A (P-loop).
216595014755	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
216595014756	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
216595014757	tetramer interface [polypeptide binding]; other site
216595014758	active site
216595014759	Mg2+/Mn2+ binding site [ion binding]; other site
216595014761	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595014762	PAS domain; Region: PAS_9; pfam13426
216595014763	putative active site [active]
216595014764	heme pocket [chemical binding]; other site
216595014765	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595014766	PAS domain; Region: PAS_9; pfam13426
216595014767	putative active site [active]
216595014768	heme pocket [chemical binding]; other site
216595014769	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
216595014770	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595014771	dimer interface [polypeptide binding]; other site
216595014772	putative CheW interface [polypeptide binding]; other site
216595014776	PS00017 ATP/GTP-binding site motif A (P-loop).
216595014777	Predicted transcriptional regulators [Transcription]; Region: COG1733
216595014778	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
216595014780	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333
216595014781	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
216595014782	dimer interface [polypeptide binding]; other site
216595014783	active site
216595014785	PS00606 Beta-ketoacyl synthases active site.
216595014787	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
216595014788	homotrimer interaction site [polypeptide binding]; other site
216595014789	putative active site [active]
216595014791	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
216595014792	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
216595014793	Peptidase family U32; Region: Peptidase_U32; pfam01136
216595014794	Collagenase; Region: DUF3656; pfam12392
216595014796	PS01276 Peptidase family U32 signature.
216595014797	PS00225 Crystallins beta and gamma 'Greek key' motif signature.
216595014798	EamA-like transporter family; Region: EamA; pfam00892
216595014799	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
216595014800	EamA-like transporter family; Region: EamA; pfam00892
216595014803	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
216595014804	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
216595014805	AsnC family; Region: AsnC_trans_reg; pfam01037
216595014806	PS00519 Bacterial regulatory proteins, asnC family signature.
216595014808	5 probable transmembrane helices predicted for PFLU3114 by TMHMM2.0 at aa 20-39, 83-100, 110-132, 137-156 and 166-188
216595014809	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
216595014810	D-xylulose kinase; Region: XylB; TIGR01312
216595014811	N- and C-terminal domain interface [polypeptide binding]; other site
216595014812	active site
216595014813	MgATP binding site [chemical binding]; other site
216595014814	catalytic site [active]
216595014815	metal binding site [ion binding]; metal-binding site
216595014816	xylulose binding site [chemical binding]; other site
216595014817	homodimer interface [polypeptide binding]; other site
216595014820	PS00933 FGGY family of carbohydrate kinases signature 1.
216595014821	Transcriptional regulators [Transcription]; Region: PurR; COG1609
216595014822	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
216595014823	DNA binding site [nucleotide binding]
216595014824	domain linker motif; other site
216595014825	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
216595014826	dimerization interface [polypeptide binding]; other site
216595014827	ligand binding site [chemical binding]; other site
216595014830	PS00356 Bacterial regulatory proteins, lacI family signature.
216595014831	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
216595014832	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321
216595014833	putative ligand binding site [chemical binding]; other site
216595014835	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
216595014836	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
216595014837	TM-ABC transporter signature motif; other site
216595014839	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
216595014840	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
216595014841	Walker A/P-loop; other site
216595014842	ATP binding site [chemical binding]; other site
216595014843	Q-loop/lid; other site
216595014844	ABC transporter signature motif; other site
216595014845	Walker B; other site
216595014846	D-loop; other site
216595014847	H-loop/switch region; other site
216595014848	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
216595014850	PS00211 ABC transporters family signature.
216595014852	PS00017 ATP/GTP-binding site motif A (P-loop).
216595014853	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
216595014855	Thermostable hemolysin; Region: T_hemolysin; pfam12261
216595014856	PS00141 Eukaryotic and viral aspartyl proteases active site.
216595014857	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_3; cd05914
216595014858	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
216595014859	acyl-activating enzyme (AAE) consensus motif; other site
216595014860	putative AMP binding site [chemical binding]; other site
216595014861	putative active site [active]
216595014862	putative CoA binding site [chemical binding]; other site
216595014864	PS00455 Putative AMP-binding domain signature.
216595014865	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
216595014866	heme binding pocket [chemical binding]; other site
216595014867	heme ligand [chemical binding]; other site
216595014868	short chain dehydrogenase; Provisional; Region: PRK09072
216595014869	classical (c) SDRs; Region: SDR_c; cd05233
216595014870	NAD(P) binding site [chemical binding]; other site
216595014871	active site
216595014873	1 probable transmembrane helix predicted for PFLU3124 by TMHMM2.0 at aa 13-35
216595014874	PS00061 Short-chain dehydrogenases/reductases family signature.
216595014876	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
216595014877	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595014878	active site
216595014879	phosphorylation site [posttranslational modification]
216595014880	intermolecular recognition site; other site
216595014881	dimerization interface [polypeptide binding]; other site
216595014882	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216595014883	DNA binding site [nucleotide binding]
216595014886	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
216595014887	HAMP domain; Region: HAMP; pfam00672
216595014888	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595014889	dimer interface [polypeptide binding]; other site
216595014890	phosphorylation site [posttranslational modification]
216595014891	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595014892	ATP binding site [chemical binding]; other site
216595014893	Mg2+ binding site [ion binding]; other site
216595014894	G-X-G motif; other site
216595014895	2 probable transmembrane helices predicted for PFLU3127 by TMHMM2.0 at aa 10-29 and 166-188
216595014899	PAS domain S-box; Region: sensory_box; TIGR00229
216595014900	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595014901	putative active site [active]
216595014902	heme pocket [chemical binding]; other site
216595014903	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
216595014904	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595014905	dimer interface [polypeptide binding]; other site
216595014906	phosphorylation site [posttranslational modification]
216595014907	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595014908	ATP binding site [chemical binding]; other site
216595014909	Mg2+ binding site [ion binding]; other site
216595014910	G-X-G motif; other site
216595014914	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
216595014915	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595014916	active site
216595014917	phosphorylation site [posttranslational modification]
216595014918	intermolecular recognition site; other site
216595014919	dimerization interface [polypeptide binding]; other site
216595014921	Response regulator receiver domain; Region: Response_reg; pfam00072
216595014922	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595014923	active site
216595014924	phosphorylation site [posttranslational modification]
216595014925	intermolecular recognition site; other site
216595014926	dimerization interface [polypeptide binding]; other site
216595014927	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
216595014930	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
216595014931	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
216595014932	12 probable transmembrane helices predicted for PFLU3131 by TMHMM2.0 at aa 15-37, 44-66, 81-98, 105-127, 132-154, 167-189, 209-228, 248-270, 339-361, 368-390, 400-422 and 427-446
216595014934	Uncharacterized conserved protein [Function unknown]; Region: COG2308
216595014937	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
216595014938	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
216595014940	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
216595014941	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
216595014943	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
216595014944	DEAD/DEAH box helicase; Region: DEAD; pfam00270
216595014945	DEAD_2; Region: DEAD_2; pfam06733
216595014946	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
216595014948	PS00690 DEAH-box subfamily ATP-dependent helicases signature.
216595014949	PS00017 ATP/GTP-binding site motif A (P-loop).
216595014950	This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990
216595014952	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
216595014954	1 probable transmembrane helix predicted for PFLU3140 by TMHMM2.0 at aa 7-29
216595014955	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595014956	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
216595014957	nucleophilic elbow; other site
216595014958	catalytic triad; other site
216595014959	PS00012 Phosphopantetheine attachment site.
216595014961	PS00330 Hemolysin-type calcium-binding region signature.
216595014964	PS00120 Lipases, serine active site.
216595014965	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
216595014968	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
216595014969	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
216595014970	HlyD family secretion protein; Region: HlyD_3; pfam13437
216595014972	1 probable transmembrane helix predicted for PFLU3143 by TMHMM2.0 at aa 21-40
216595014973	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
216595014974	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
216595014975	Walker A/P-loop; other site
216595014976	ATP binding site [chemical binding]; other site
216595014977	Q-loop/lid; other site
216595014978	ABC transporter signature motif; other site
216595014979	Walker B; other site
216595014980	D-loop; other site
216595014981	H-loop/switch region; other site
216595014983	PS00211 ABC transporters family signature.
216595014984	PS00017 ATP/GTP-binding site motif A (P-loop).
216595014985	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595014986	Protease inhibitor Inh; Region: Inh; pfam02974
216595014988	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
216595014989	active site
216595014990	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
216595014992	PS00330 Hemolysin-type calcium-binding region signature.
216595014996	PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.
216595014997	PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide.
216595014998	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
216595014999	homodimer interface [polypeptide binding]; other site
216595015000	homotetramer interface [polypeptide binding]; other site
216595015001	active site pocket [active]
216595015002	cleavage site
216595015004	amino acid transporter; Region: 2A0306; TIGR00909
216595015006	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
216595015007	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216595015008	DNA binding residues [nucleotide binding]
216595015009	dimerization interface [polypeptide binding]; other site
216595015011	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
216595015012	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
216595015014	PS00017 ATP/GTP-binding site motif A (P-loop).
216595015015	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
216595015017	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
216595015018	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
216595015020	SnoaL-like domain; Region: SnoaL_2; pfam12680
216595015021	Helix-turn-helix domain; Region: HTH_18; pfam12833
216595015022	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595015024	PS00041 Bacterial regulatory proteins, araC family signature.
216595015025	Protein of unknown function (DUF1652); Region: DUF1652; pfam07865
216595015027	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
216595015028	Family description; Region: UvrD_C_2; pfam13538
216595015030	PS00017 ATP/GTP-binding site motif A (P-loop).
216595015031	Pirin-related protein [General function prediction only]; Region: COG1741
216595015032	Pirin; Region: Pirin; pfam02678
216595015035	phosphoglucomutase; Validated; Region: PRK07564
216595015036	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
216595015037	active site
216595015038	substrate binding site [chemical binding]; other site
216595015039	metal binding site [ion binding]; metal-binding site
216595015042	PS00017 ATP/GTP-binding site motif A (P-loop).
216595015045	PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature.
216595015046	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
216595015047	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595015048	DNA-binding site [nucleotide binding]; DNA binding site
216595015049	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
216595015050	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
216595015051	catalytic residue [active]
216595015054	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
216595015055	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268
216595015056	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
216595015057	putative NAD(P) binding site [chemical binding]; other site
216595015060	PS00059 Zinc-containing alcohol dehydrogenases signature.
216595015061	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595015062	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595015063	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464
216595015064	putative substrate binding pocket [chemical binding]; other site
216595015065	putative dimerization interface [polypeptide binding]; other site
216595015068	Uncharacterized conserved protein [Function unknown]; Region: COG0398
216595015069	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
216595015070	4 probable transmembrane helices predicted for PFLU3165 by TMHMM2.0 at aa 35-57, 72-94, 154-176 and 196-215
216595015072	Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893
216595015073	Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893
216595015074	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
216595015075	putative hydrophobic ligand binding site [chemical binding]; other site
216595015076	protein interface [polypeptide binding]; other site
216595015077	gate; other site
216595015078	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
216595015080	1 probable transmembrane helix predicted for PFLU3170 by TMHMM2.0 at aa 15-37
216595015081	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
216595015082	classical (c) SDRs; Region: SDR_c; cd05233
216595015083	NAD(P) binding site [chemical binding]; other site
216595015084	active site
216595015086	PS00061 Short-chain dehydrogenases/reductases family signature.
216595015087	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
216595015088	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
216595015089	FMN binding site [chemical binding]; other site
216595015090	active site
216595015091	substrate binding site [chemical binding]; other site
216595015092	catalytic residue [active]
216595015094	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
216595015095	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216595015098	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
216595015099	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216595015101	aspartate aminotransferase; Provisional; Region: PRK05764
216595015102	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216595015103	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595015104	homodimer interface [polypeptide binding]; other site
216595015105	catalytic residue [active]
216595015107	PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site.
216595015108	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216595015109	NADH(P)-binding; Region: NAD_binding_10; pfam13460
216595015110	NAD(P) binding site [chemical binding]; other site
216595015111	active site
216595015113	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
216595015114	NAD binding site [chemical binding]; other site
216595015115	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
216595015116	active site
216595015118	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
216595015119	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216595015121	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595015122	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595015123	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427
216595015124	putative dimerization interface [polypeptide binding]; other site
216595015127	Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893
216595015128	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
216595015129	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
216595015130	substrate binding pocket [chemical binding]; other site
216595015131	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
216595015133	Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893
216595015134	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
216595015135	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
216595015136	active site
216595015137	FMN binding site [chemical binding]; other site
216595015138	substrate binding site [chemical binding]; other site
216595015139	homotetramer interface [polypeptide binding]; other site
216595015140	catalytic residue [active]
216595015142	Predicted transcriptional regulators [Transcription]; Region: COG1733
216595015143	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
216595015145	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
216595015146	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
216595015148	PS00462 Gamma-glutamyltranspeptidase signature.
216595015149	1 probable transmembrane helix predicted for PFLU3186 by TMHMM2.0 at aa 39-56
216595015150	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
216595015151	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
216595015153	PS00714 Sodium:dicarboxylate symporter family signature 2.
216595015154	PS00713 Sodium:dicarboxylate symporter family signature 1.
216595015155	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357
216595015156	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
216595015157	putative metal binding site [ion binding]; other site
216595015159	haemagglutination activity domain; Region: Haemagg_act; pfam05860
216595015160	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
216595015161	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
216595015162	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
216595015163	Possible hemagglutinin (DUF637); Region: DUF637; pfam04830
216595015164	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
216595015165	protein-splicing catalytic site; other site
216595015166	thioester formation/cholesterol transfer; other site
216595015167	Pretoxin HINT domain; Region: PT-HINT; pfam07591
216595015175	PS00017 ATP/GTP-binding site motif A (P-loop).
216595015201	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
216595015202	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
216595015203	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
216595015206	2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012
216595015207	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
216595015208	dimer interface [polypeptide binding]; other site
216595015209	TPP-binding site [chemical binding]; other site
216595015210	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
216595015211	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
216595015212	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216595015213	NAD(P) binding site [chemical binding]; other site
216595015214	active site
216595015216	PS00061 Short-chain dehydrogenases/reductases family signature.
216595015217	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
216595015218	FAD binding domain; Region: FAD_binding_4; pfam01565
216595015221	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
216595015222	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
216595015224	PS00017 ATP/GTP-binding site motif A (P-loop).
216595015225	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
216595015226	active site
216595015228	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
216595015229	active site
216595015233	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
216595015234	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
216595015235	dimer interface [polypeptide binding]; other site
216595015236	active site
216595015239	PS00606 Beta-ketoacyl synthases active site.
216595015240	acyl carrier protein; Provisional; Region: acpP; PRK00982
216595015242	PS00012 Phosphopantetheine attachment site.
216595015243	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
216595015244	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
216595015245	dimer interface [polypeptide binding]; other site
216595015246	active site
216595015247	CoA binding pocket [chemical binding]; other site
216595015250	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
216595015251	EamA-like transporter family; Region: EamA; pfam00892
216595015254	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595015255	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
216595015256	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216595015257	non-specific DNA binding site [nucleotide binding]; other site
216595015258	salt bridge; other site
216595015259	sequence-specific DNA binding site [nucleotide binding]; other site
216595015261	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
216595015263	PS00041 Bacterial regulatory proteins, araC family signature.
216595015265	Haem-containing dehydratase; Region: Dehydratase_hem; pfam13816
216595015266	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
216595015267	amidase; Provisional; Region: PRK07235
216595015268	indole acetimide hydrolase; Validated; Region: PRK07488
216595015270	PS00571 Amidases signature.
216595015271	Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979
216595015272	putative TOMM peptide; Region: TOMM_nitrile_2; TIGR04351
216595015273	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
216595015275	Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211
216595015276	nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888
216595015278	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
216595015279	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
216595015280	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
216595015282	PS00017 ATP/GTP-binding site motif A (P-loop).
216595015284	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595015285	PAS fold; Region: PAS_3; pfam08447
216595015286	putative active site [active]
216595015287	heme pocket [chemical binding]; other site
216595015291	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
216595015292	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
216595015293	acyl-activating enzyme (AAE) consensus motif; other site
216595015294	AMP binding site [chemical binding]; other site
216595015295	active site
216595015296	CoA binding site [chemical binding]; other site
216595015298	PS00455 Putative AMP-binding domain signature.
216595015299	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
216595015300	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216595015302	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
216595015303	Protein export membrane protein; Region: SecD_SecF; cl14618
216595015305	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
216595015306	HlyD family secretion protein; Region: HlyD_3; pfam13437
216595015308	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595015309	diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938
216595015310	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
216595015311	inhibitor-cofactor binding pocket; inhibition site
216595015312	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595015313	catalytic residue [active]
216595015315	PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site.
216595015316	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
216595015317	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216595015318	N-terminal plug; other site
216595015319	ligand-binding site [chemical binding]; other site
216595015322	PFI-7
216595015323	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
216595015324	active site
216595015325	iron coordination sites [ion binding]; other site
216595015327	acyl-CoA synthetase; Validated; Region: PRK05850
216595015328	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
216595015329	acyl-activating enzyme (AAE) consensus motif; other site
216595015330	active site
216595015331	Condensation domain; Region: Condensation; pfam00668
216595015332	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
216595015333	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
216595015335	PS00211 ABC transporters family signature.
216595015336	PS00455 Putative AMP-binding domain signature.
216595015339	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
216595015341	Condensation domain; Region: Condensation; pfam00668
216595015342	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
216595015343	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
216595015344	acyl-activating enzyme (AAE) consensus motif; other site
216595015345	AMP binding site [chemical binding]; other site
216595015346	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
216595015349	PS00455 Putative AMP-binding domain signature.
216595015351	PS00012 Phosphopantetheine attachment site.
216595015352	Condensation domain; Region: Condensation; pfam00668
216595015353	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
216595015354	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
216595015355	acyl-activating enzyme (AAE) consensus motif; other site
216595015356	AMP binding site [chemical binding]; other site
216595015357	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
216595015358	Condensation domain; Region: Condensation; pfam00668
216595015359	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
216595015360	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
216595015361	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
216595015362	acyl-activating enzyme (AAE) consensus motif; other site
216595015363	AMP binding site [chemical binding]; other site
216595015364	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
216595015365	Condensation domain; Region: Condensation; pfam00668
216595015366	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
216595015367	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
216595015368	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
216595015369	acyl-activating enzyme (AAE) consensus motif; other site
216595015370	AMP binding site [chemical binding]; other site
216595015371	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
216595015372	Condensation domain; Region: Condensation; pfam00668
216595015373	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
216595015374	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
216595015375	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
216595015376	acyl-activating enzyme (AAE) consensus motif; other site
216595015377	AMP binding site [chemical binding]; other site
216595015378	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
216595015379	Condensation domain; Region: Condensation; pfam00668
216595015380	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
216595015383	PS00455 Putative AMP-binding domain signature.
216595015384	PS00904 Protein prenyltransferases alpha subunit repeat signature.
216595015386	PS00012 Phosphopantetheine attachment site.
216595015389	PS00455 Putative AMP-binding domain signature.
216595015393	PS00455 Putative AMP-binding domain signature.
216595015395	PS00012 Phosphopantetheine attachment site.
216595015398	PS00455 Putative AMP-binding domain signature.
216595015400	PS00012 Phosphopantetheine attachment site.
216595015402	Condensation domain; Region: Condensation; pfam00668
216595015403	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
216595015404	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
216595015405	acyl-activating enzyme (AAE) consensus motif; other site
216595015406	AMP binding site [chemical binding]; other site
216595015407	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
216595015408	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
216595015409	Condensation domain; Region: Condensation; pfam00668
216595015410	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
216595015411	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
216595015412	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
216595015413	acyl-activating enzyme (AAE) consensus motif; other site
216595015414	AMP binding site [chemical binding]; other site
216595015415	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
216595015416	Condensation domain; Region: Condensation; pfam00668
216595015417	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
216595015418	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
216595015419	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
216595015422	PS00455 Putative AMP-binding domain signature.
216595015427	PS00455 Putative AMP-binding domain signature.
216595015428	PS00904 Protein prenyltransferases alpha subunit repeat signature.
216595015430	PS00012 Phosphopantetheine attachment site.
216595015433	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
216595015434	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
216595015435	acyl-activating enzyme (AAE) consensus motif; other site
216595015436	AMP binding site [chemical binding]; other site
216595015437	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
216595015438	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
216595015441	PS00455 Putative AMP-binding domain signature.
216595015444	ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615
216595015445	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
216595015446	Walker A/P-loop; other site
216595015447	ATP binding site [chemical binding]; other site
216595015448	Q-loop/lid; other site
216595015449	ABC transporter signature motif; other site
216595015450	Walker B; other site
216595015451	D-loop; other site
216595015452	H-loop/switch region; other site
216595015453	6 probable transmembrane helices predicted for PFLU3226 by TMHMM2.0 at aa 12-34, 49-68, 122-144, 149-166, 231-253 and 268-290
216595015454	PS00639 Eukaryotic thiol (cysteine) proteases histidine active site.
216595015456	PS00017 ATP/GTP-binding site motif A (P-loop).
216595015457	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
216595015458	siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951
216595015459	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
216595015460	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
216595015461	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
216595015462	5 probable transmembrane helices predicted for PFLU3228 by TMHMM2.0 at aa 21-43, 65-87, 144-166, 181-203 and 274-296
216595015464	PS00017 ATP/GTP-binding site motif A (P-loop).
216595015466	Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866
216595015467	Amb_all domain; Region: Amb_all; smart00656
216595015468	1 probable transmembrane helix predicted for PFLU3229 by TMHMM2.0 at aa 12-34
216595015470	type II secretion system secreton cluster 2
216595015471	type II secretion system protein F; Region: GspF; TIGR02120
216595015472	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
216595015473	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
216595015476	type II secretion system protein E; Region: type_II_gspE; TIGR02533
216595015477	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
216595015478	Walker A motif; other site
216595015479	ATP binding site [chemical binding]; other site
216595015480	Walker B motif; other site
216595015482	PS00662 Bacterial type II secretion system protein E signature.
216595015483	PS00017 ATP/GTP-binding site motif A (P-loop).
216595015484	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
216595015485	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
216595015486	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
216595015487	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
216595015488	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
216595015493	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595015494	Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612
216595015496	1 probable transmembrane helix predicted for PFLU3233 by TMHMM2.0 at aa 49-66
216595015497	type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709
216595015498	GspL periplasmic domain; Region: GspL_C; cl14909
216595015500	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
216595015502	1 probable transmembrane helix predicted for PFLU3235 by TMHMM2.0 at aa 13-35
216595015503	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
216595015504	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
216595015505	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
216595015508	1 probable transmembrane helix predicted for PFLU3236 by TMHMM2.0 at aa 21-43
216595015509	PS00409 Prokaryotic N-terminal methylation site.
216595015510	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
216595015512	PS00409 Prokaryotic N-terminal methylation site.
216595015513	1 probable transmembrane helix predicted for PFLU3237 by TMHMM2.0 at aa 12-34
216595015515	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
216595015516	type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708
216595015517	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
216595015519	PS00409 Prokaryotic N-terminal methylation site.
216595015520	1 probable transmembrane helix predicted for PFLU3239 by TMHMM2.0 at aa 20-42
216595015521	Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795
216595015522	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
216595015523	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
216595015525	PS00409 Prokaryotic N-terminal methylation site.
216595015526	1 probable transmembrane helix predicted for PFLU3240 by TMHMM2.0 at aa 7-29
216595015527	PS00018 EF-hand calcium-binding domain.
216595015528	haemagglutination activity domain; Region: Haemagg_act; pfam05860
216595015529	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
216595015530	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
216595015531	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
216595015532	PS00017 ATP/GTP-binding site motif A (P-loop).
216595015533	PS00107 Protein kinases ATP-binding region signature.
216595015562	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
216595015563	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
216595015564	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
216595015567	His-Xaa-Ser system protein HsxD; Region: chp_LLNDYxLRE; TIGR03976
216595015568	His-Xaa-Ser system radical SAM maturase HxsB; Region: rSAM_paired_1; TIGR03978
216595015569	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216595015570	FeS/SAM binding site; other site
216595015571	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
216595015573	His-Xaa-Ser system radical SAM maturase HxsC; Region: rSAM_pair_HxsC; TIGR03977
216595015574	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216595015575	FeS/SAM binding site; other site
216595015577	His-Xaa-Ser repeat protein HxsA; Region: His_Ser_Rich; TIGR03979
216595015578	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
216595015580	6 probable transmembrane helices predicted for PFLU3253 by TMHMM2.0 at aa 50-67, 77-99, 112-131, 146-168, 170-189 and 209-231
216595015581	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
216595015582	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216595015583	metal binding site [ion binding]; metal-binding site
216595015584	active site
216595015585	I-site; other site
216595015586	4 probable transmembrane helices predicted for PFLU3255 by TMHMM2.0 at aa 36-58, 62-83, 100-122 and 175-197
216595015588	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
216595015589	Cytochrome P450; Region: p450; cl12078
216595015590	PS00086 Cytochrome P450 cysteine heme-iron ligand signature.
216595015591	PS00237 G-protein coupled receptors signature.
216595015592	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
216595015593	putative DNA binding site [nucleotide binding]; other site
216595015594	dimerization interface [polypeptide binding]; other site
216595015595	putative Zn2+ binding site [ion binding]; other site
216595015597	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
216595015598	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216595015599	Walker A/P-loop; other site
216595015600	ATP binding site [chemical binding]; other site
216595015601	Q-loop/lid; other site
216595015602	ABC transporter signature motif; other site
216595015603	Walker B; other site
216595015604	D-loop; other site
216595015605	H-loop/switch region; other site
216595015607	PS00211 ABC transporters family signature.
216595015608	PS00017 ATP/GTP-binding site motif A (P-loop).
216595015609	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595015610	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595015611	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
216595015612	putative effector binding pocket; other site
216595015613	dimerization interface [polypeptide binding]; other site
216595015616	PS00044 Bacterial regulatory proteins, lysR family signature.
216595015617	Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999
216595015618	active site
216595015619	Mn binding site [ion binding]; other site
216595015621	PS00148 Arginase family signature 2.
216595015622	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
216595015623	Amidase; Region: Amidase; pfam01425
216595015625	PS00571 Amidases signature.
216595015626	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595015627	Major Facilitator Superfamily; Region: MFS_1; pfam07690
216595015629	PS00216 Sugar transport proteins signature 1.
216595015630	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
216595015631	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595015632	Helix-turn-helix domain; Region: HTH_18; pfam12833
216595015633	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595015635	PS00041 Bacterial regulatory proteins, araC family signature.
216595015637	homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337
216595015638	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
216595015640	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
216595015641	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
216595015642	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595015645	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
216595015646	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
216595015648	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
216595015649	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
216595015651	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299
216595015652	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
216595015653	NAD binding site [chemical binding]; other site
216595015654	catalytic residues [active]
216595015656	PS00687 Aldehyde dehydrogenases glutamic acid active site.
216595015657	PS00070 Aldehyde dehydrogenases cysteine active site.
216595015658	The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370
216595015659	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
216595015660	putative active site [active]
216595015661	putative metal binding site [ion binding]; other site
216595015663	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
216595015664	putative substrate binding pocket [chemical binding]; other site
216595015665	trimer interface [polypeptide binding]; other site
216595015667	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
216595015668	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595015669	putative substrate translocation pore; other site
216595015670	12 probable transmembrane helices predicted for PFLU3274 by TMHMM2.0 at aa 21-40, 60-79, 92-111, 116-138, 150-172, 182-204, 249-271, 286-305, 318-337, 341-363, 375-397 and 407-424
216595015672	2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312
216595015674	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Region: HpaI; TIGR02311
216595015676	homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337
216595015677	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
216595015679	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
216595015680	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
216595015682	PS00626 Regulator of chromosome condensation (RCC1) signature 2.
216595015683	Protein of unknown function (DUF861); Region: Cupin_3; cl17594
216595015685	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
216595015686	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216595015687	DNA binding residues [nucleotide binding]
216595015688	dimerization interface [polypeptide binding]; other site
216595015690	Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703
216595015691	classical (c) SDRs; Region: SDR_c; cd05233
216595015692	short chain dehydrogenase; Provisional; Region: PRK07478
216595015693	NAD(P) binding site [chemical binding]; other site
216595015694	active site
216595015696	PS00061 Short-chain dehydrogenases/reductases family signature.
216595015697	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
216595015698	classical (c) SDRs; Region: SDR_c; cd05233
216595015699	NAD(P) binding site [chemical binding]; other site
216595015700	active site
216595015702	PS00061 Short-chain dehydrogenases/reductases family signature.
216595015703	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
216595015704	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216595015706	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
216595015707	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595015709	PS00041 Bacterial regulatory proteins, araC family signature.
216595015710	Protein of unknown function (DUF3156); Region: DUF3156; pfam11354
216595015711	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
216595015713	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
216595015715	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
216595015716	Transcriptional regulators [Transcription]; Region: MarR; COG1846
216595015718	Naphthocyclinone hydroxylase; Region: NcnH; cd01159
216595015719	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
216595015720	Flavin binding site [chemical binding]; other site
216595015722	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
216595015723	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
216595015724	NAD(P) binding site [chemical binding]; other site
216595015725	catalytic residues [active]
216595015727	PS00070 Aldehyde dehydrogenases cysteine active site.
216595015728	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
216595015729	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216595015730	NAD(P) binding site [chemical binding]; other site
216595015731	active site
216595015733	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
216595015734	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
216595015735	iron-sulfur cluster [ion binding]; other site
216595015736	[2Fe-2S] cluster binding site [ion binding]; other site
216595015737	C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878
216595015738	alpha subunit interface [polypeptide binding]; other site
216595015739	active site
216595015740	substrate binding site [chemical binding]; other site
216595015741	Fe binding site [ion binding]; other site
216595015743	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
216595015744	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
216595015745	FMN-binding pocket [chemical binding]; other site
216595015746	flavin binding motif; other site
216595015747	phosphate binding motif [ion binding]; other site
216595015748	beta-alpha-beta structure motif; other site
216595015749	NAD binding pocket [chemical binding]; other site
216595015750	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
216595015751	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
216595015752	catalytic loop [active]
216595015753	iron binding site [ion binding]; other site
216595015757	PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature.
216595015758	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
216595015759	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595015760	DNA-binding site [nucleotide binding]; DNA binding site
216595015761	FCD domain; Region: FCD; pfam07729
216595015764	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
216595015765	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
216595015766	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
216595015767	active site
216595015768	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
216595015771	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
216595015772	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
216595015773	dimer interface [polypeptide binding]; other site
216595015774	active site
216595015776	PS00099 Thiolases active site.
216595015777	PS00737 Thiolases signature 2.
216595015779	feruloyl-CoA synthase; Reviewed; Region: PRK08180
216595015780	Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921
216595015781	acyl-activating enzyme (AAE) consensus motif; other site
216595015782	putative AMP binding site [chemical binding]; other site
216595015783	putative active site [active]
216595015784	putative CoA binding site [chemical binding]; other site
216595015786	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
216595015787	Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105
216595015788	NAD(P) binding site [chemical binding]; other site
216595015789	catalytic residues [active]
216595015791	PS00687 Aldehyde dehydrogenases glutamic acid active site.
216595015792	PS00070 Aldehyde dehydrogenases cysteine active site.
216595015793	p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120
216595015794	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
216595015795	substrate binding site [chemical binding]; other site
216595015796	oxyanion hole (OAH) forming residues; other site
216595015797	trimer interface [polypeptide binding]; other site
216595015799	PS00166 Enoyl-CoA hydratase/isomerase signature.
216595015800	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
216595015801	MarR family; Region: MarR_2; pfam12802
216595015803	outer membrane porin, OprD family; Region: OprD; pfam03573
216595015805	low G+C content region (38.56%)
216595015806	putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551
216595015807	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595015808	12 probable transmembrane helices predicted for PFLU3303 by TMHMM2.0 at aa 12-34, 47-69, 76-95, 100-122, 135-157, 161-183, 219-241, 251-273, 278-297, 302-324, 337-359 and 369-391
216595015810	PS00216 Sugar transport proteins signature 1.
216595015811	PS00217 Sugar transport proteins signature 2.
216595015812	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
216595015813	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
216595015814	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
216595015815	NAD(P) binding site [chemical binding]; other site
216595015816	3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428
216595015817	active site
216595015819	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
216595015820	NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152
216595015821	NAD(P) binding site [chemical binding]; other site
216595015822	catalytic residues [active]
216595015824	PS00687 Aldehyde dehydrogenases glutamic acid active site.
216595015825	Activator of aromatic catabolism; Region: XylR_N; pfam06505
216595015826	V4R domain; Region: V4R; pfam02830
216595015827	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
216595015828	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595015829	Walker A motif; other site
216595015830	ATP binding site [chemical binding]; other site
216595015831	Walker B motif; other site
216595015832	arginine finger; other site
216595015836	PS00675 Sigma-54 interaction domain ATP-binding region A signature.
216595015837	PS00676 Sigma-54 interaction domain ATP-binding region B signature.
216595015839	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
216595015840	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216595015842	PS01081 Bacterial regulatory proteins, tetR family signature.
216595015843	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
216595015844	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
216595015846	PS00107 Protein kinases ATP-binding region signature.
216595015847	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
216595015848	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
216595015849	Beta-lactamase; Region: Beta-lactamase; pfam00144
216595015851	Isochorismatase family; Region: Isochorismatase; pfam00857
216595015852	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
216595015853	catalytic triad [active]
216595015854	conserved cis-peptide bond; other site
216595015856	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
216595015857	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14263
216595015858	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
216595015859	Walker A/P-loop; other site
216595015860	ATP binding site [chemical binding]; other site
216595015861	Q-loop/lid; other site
216595015862	ABC transporter signature motif; other site
216595015863	Walker B; other site
216595015864	D-loop; other site
216595015865	H-loop/switch region; other site
216595015867	PS00211 ABC transporters family signature.
216595015868	PS00017 ATP/GTP-binding site motif A (P-loop).
216595015869	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
216595015870	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595015871	dimer interface [polypeptide binding]; other site
216595015872	conserved gate region; other site
216595015873	putative PBP binding loops; other site
216595015874	ABC-ATPase subunit interface; other site
216595015876	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
216595015877	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595015878	dimer interface [polypeptide binding]; other site
216595015879	conserved gate region; other site
216595015880	putative PBP binding loops; other site
216595015881	ABC-ATPase subunit interface; other site
216595015883	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595015884	phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975
216595015886	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
216595015888	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
216595015889	trehalose synthase, Pseudomonas stutzeri type; Region: TreS_stutzeri; TIGR02455
216595015890	PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site.
216595015891	PAS fold; Region: PAS_4; pfam08448
216595015892	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
216595015893	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595015895	PS00041 Bacterial regulatory proteins, araC family signature.
216595015897	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
216595015898	14 probable transmembrane helices predicted for PFLU3323 by TMHMM2.0 at aa 12-34, 44-66, 86-108, 130-152, 159-181, 201-223, 236-258, 281-303, 337-359, 364-386, 399-421, 425-447, 460-482 and 492-514
216595015900	hydroxyproline-2-epimerase; Provisional; Region: PRK13970
216595015901	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
216595015903	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
216595015904	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
216595015905	inhibitor site; inhibition site
216595015906	active site
216595015907	dimer interface [polypeptide binding]; other site
216595015908	catalytic residue [active]
216595015910	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
216595015911	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
216595015912	dimer interface [polypeptide binding]; other site
216595015913	NADP binding site [chemical binding]; other site
216595015914	catalytic residues [active]
216595015916	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
216595015917	hydroxyglutarate oxidase; Provisional; Region: PRK11728
216595015919	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
216595015920	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
216595015921	conserved cys residue [active]
216595015925	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
216595015927	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
216595015928	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595015929	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
216595015930	dimerization interface [polypeptide binding]; other site
216595015931	substrate binding pocket [chemical binding]; other site
216595015932	PS00228 Tubulin-beta mRNA autoregulation signal.
216595015935	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
216595015936	EamA-like transporter family; Region: EamA; cl17759
216595015937	EamA-like transporter family; Region: EamA; pfam00892
216595015938	9 probable transmembrane helices predicted for PFLU3331 by TMHMM2.0 at aa 4-23, 30-52, 57-76, 89-108, 112-130, 137-159, 169-191, 204-226 and 241-263
216595015940	short chain dehydrogenase; Provisional; Region: PRK06123
216595015941	classical (c) SDRs; Region: SDR_c; cd05233
216595015942	NAD(P) binding site [chemical binding]; other site
216595015943	active site
216595015945	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
216595015946	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216595015948	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
216595015949	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
216595015950	FMN binding site [chemical binding]; other site
216595015951	active site
216595015952	substrate binding site [chemical binding]; other site
216595015953	catalytic residue [active]
216595015955	short chain dehydrogenase; Provisional; Region: PRK06181
216595015956	classical (c) SDRs; Region: SDR_c; cd05233
216595015957	NAD(P) binding site [chemical binding]; other site
216595015958	active site
216595015960	PS00061 Short-chain dehydrogenases/reductases family signature.
216595015961	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
216595015962	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
216595015963	putative NAD(P) binding site [chemical binding]; other site
216595015966	short chain dehydrogenase; Provisional; Region: PRK06179
216595015967	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
216595015968	NADP binding site [chemical binding]; other site
216595015969	active site
216595015970	steroid binding site; other site
216595015972	PFI-8
216595015973	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
216595015974	Coenzyme A binding pocket [chemical binding]; other site
216595015976	1 probable transmembrane helix predicted for PFLU3344 by TMHMM2.0 at aa 10-32
216595015977	Y-family of DNA polymerases; Region: PolY; cl12025
216595015978	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
216595015980	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
216595015981	active site
216595015982	DNA binding site [nucleotide binding]
216595015983	Int/Topo IB signature motif; other site
216595015985	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343
216595015986	Anti-sigma-K factor rskA; Region: RskA; pfam10099
216595015987	1 probable transmembrane helix predicted for PFLU3348 by TMHMM2.0 at aa 88-110
216595015988	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
216595015989	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
216595015990	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
216595015991	DNA binding residues [nucleotide binding]
216595015993	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595015995	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
216595015996	Fasciclin domain; Region: Fasciclin; pfam02469
216595015998	1 probable transmembrane helix predicted for PFLU3350 by TMHMM2.0 at aa 9-31
216595015999	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
216595016000	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595016001	dimerization interface [polypeptide binding]; other site
216595016002	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595016003	dimer interface [polypeptide binding]; other site
216595016004	putative CheW interface [polypeptide binding]; other site
216595016007	Penicillin amidase; Region: Penicil_amidase; pfam01804
216595016008	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
216595016009	Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936
216595016010	active site
216595016011	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
216595016013	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595016014	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595016015	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
216595016016	putative effector binding pocket; other site
216595016017	putative dimerization interface [polypeptide binding]; other site
216595016020	PS00044 Bacterial regulatory proteins, lysR family signature.
216595016021	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
216595016022	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
216595016023	active site
216595016024	catalytic tetrad [active]
216595016026	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595016027	dimerization interface [polypeptide binding]; other site
216595016028	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
216595016029	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595016030	dimer interface [polypeptide binding]; other site
216595016031	putative CheW interface [polypeptide binding]; other site
216595016032	3 probable transmembrane helices predicted for PFLU3358 by TMHMM2.0 at aa 13-35, 280-302 and 309-331
216595016035	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
216595016036	hydrophobic ligand binding site; other site
216595016037	Predicted metal-binding protein [General function prediction only]; Region: COG3019
216595016039	Predicted membrane protein [Function unknown]; Region: COG1238
216595016040	4 probable transmembrane helices predicted for PFLU3361 by TMHMM2.0 at aa 5-23, 38-60, 91-113 and 123-145
216595016042	Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342
216595016043	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
216595016044	PS00017 ATP/GTP-binding site motif A (P-loop).
216595016046	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
216595016047	dimerization interface [polypeptide binding]; other site
216595016048	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
216595016049	NAD binding site [chemical binding]; other site
216595016050	ligand binding site [chemical binding]; other site
216595016051	catalytic site [active]
216595016054	PS00017 ATP/GTP-binding site motif A (P-loop).
216595016055	PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature.
216595016056	PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3.
216595016058	glycogen synthase; Provisional; Region: glgA; PRK00654
216595016059	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
216595016060	ADP-binding pocket [chemical binding]; other site
216595016061	homodimer interface [polypeptide binding]; other site
216595016064	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
216595016065	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
216595016066	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
216595016067	catalytic site [active]
216595016068	active site
216595016069	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
216595016072	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
216595016073	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
216595016075	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
216595016076	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
216595016077	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
216595016078	active site
216595016079	catalytic site [active]
216595016081	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
216595016082	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
216595016083	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
216595016084	active site
216595016085	catalytic site [active]
216595016088	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
216595016089	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
216595016090	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
216595016092	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
216595016094	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
216595016095	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
216595016096	DXD motif; other site
216595016098	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
216595016100	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
216595016102	Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001
216595016103	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
216595016104	active site
216595016105	Zn binding site [ion binding]; other site
216595016107	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
216595016108	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
216595016109	AsnC family; Region: AsnC_trans_reg; pfam01037
216595016111	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
216595016112	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216595016113	N-terminal plug; other site
216595016114	ligand-binding site [chemical binding]; other site
216595016117	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
216595016118	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595016119	dimer interface [polypeptide binding]; other site
216595016120	putative CheW interface [polypeptide binding]; other site
216595016121	5 probable transmembrane helices predicted for PFLU3379 by TMHMM2.0 at aa 17-35, 39-61, 82-104, 108-125 and 146-168
216595016123	NmrA-like family; Region: NmrA; pfam05368
216595016124	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
216595016125	NADP binding site [chemical binding]; other site
216595016126	active site
216595016127	regulatory binding site [polypeptide binding]; other site
216595016129	LysR family transcriptional regulator; Provisional; Region: PRK14997
216595016130	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595016131	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
216595016132	putative effector binding pocket; other site
216595016133	dimerization interface [polypeptide binding]; other site
216595016135	PS00044 Bacterial regulatory proteins, lysR family signature.
216595016137	10 probable transmembrane helices predicted for PFLU3382 by TMHMM2.0 at aa 13-35, 45-67, 80-102, 107-129, 136-155, 165-187, 199-221, 231-253, 265-282 and 287-306
216595016140	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595016141	metabolite-proton symporter; Region: 2A0106; TIGR00883
216595016142	putative substrate translocation pore; other site
216595016143	12 probable transmembrane helices predicted for PFLU3383 by TMHMM2.0 at aa 45-67, 87-109, 122-144, 149-171, 184-206, 216-238, 270-292, 307-329, 336-355, 365-387, 400-422 and 432-449
216595016145	PS00216 Sugar transport proteins signature 1.
216595016146	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
216595016148	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
216595016149	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
216595016151	1 probable transmembrane helix predicted for PFLU3386 by TMHMM2.0 at aa 22-44
216595016152	PS00070 Aldehyde dehydrogenases cysteine active site.
216595016153	PS00070 Aldehyde dehydrogenases cysteine active site.
216595016154	PS00070 Aldehyde dehydrogenases cysteine active site.
216595016155	PS00070 Aldehyde dehydrogenases cysteine active site.
216595016156	PS00070 Aldehyde dehydrogenases cysteine active site.
216595016157	1 probable transmembrane helix predicted for PFLU3387 by TMHMM2.0 at aa 10-29
216595016158	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
216595016159	A49-like RNA polymerase I associated factor; Region: RNA_pol_I_A49; pfam06870
216595016160	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
216595016161	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595016162	dimer interface [polypeptide binding]; other site
216595016163	putative CheW interface [polypeptide binding]; other site
216595016164	2 probable transmembrane helices predicted for PFLU3388 by TMHMM2.0 at aa 30-52 and 216-238
216595016166	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
216595016167	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
216595016169	PS00221 MIP family signature.
216595016170	Ferritin-like; Region: Ferritin-like; pfam12902
216595016171	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
216595016173	PS00190 Cytochrome c family heme-binding site signature.
216595016174	Protein of unknown function (DUF1203); Region: DUF1203; pfam06718
216595016175	5 probable transmembrane helices predicted for PFLU3398 by TMHMM2.0 at aa 13-32, 37-59, 66-85, 90-112 and 119-141
216595016176	Beta-lactamase; Region: Beta-lactamase; pfam00144
216595016177	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
216595016179	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
216595016180	dimer interface [polypeptide binding]; other site
216595016182	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
216595016183	active site
216595016184	catalytic triad [active]
216595016185	oxyanion hole [active]
216595016187	PS00626 Regulator of chromosome condensation (RCC1) signature 2.
216595016188	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595016189	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
216595016190	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
216595016191	dimer interface [polypeptide binding]; other site
216595016192	active site
216595016193	catalytic residue [active]
216595016195	PS00666 Dihydrodipicolinate synthetase signature 2.
216595016196	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
216595016197	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
216595016198	dimer interface [polypeptide binding]; other site
216595016199	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595016200	catalytic residue [active]
216595016201	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
216595016202	FOG: CBS domain [General function prediction only]; Region: COG0517
216595016204	PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site.
216595016206	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
216595016207	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
216595016208	homodimer interface [polypeptide binding]; other site
216595016209	substrate-cofactor binding pocket; other site
216595016210	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595016211	catalytic residue [active]
216595016213	PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site.
216595016214	YcaO domain protein; Region: TIGR03549
216595016215	OsmC-like protein; Region: OsmC; pfam02566
216595016216	YcaO-like family; Region: YcaO; pfam02624
216595016219	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595016220	PAS fold; Region: PAS_3; pfam08447
216595016221	putative active site [active]
216595016222	heme pocket [chemical binding]; other site
216595016223	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
216595016224	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595016225	dimer interface [polypeptide binding]; other site
216595016226	putative CheW interface [polypeptide binding]; other site
216595016228	1 probable transmembrane helix predicted for PFLU3409 by TMHMM2.0 at aa 167-189
216595016230	PS00139 Eukaryotic thiol (cysteine) proteases cysteine active site.
216595016231	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216595016232	Coenzyme A binding pocket [chemical binding]; other site
216595016234	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281
216595016235	4 probable transmembrane helices predicted for PFLU3414 by TMHMM2.0 at aa 7-29, 39-61, 109-131 and 141-163
216595016236	Isochorismatase family; Region: Isochorismatase; pfam00857
216595016237	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
216595016238	catalytic triad [active]
216595016239	conserved cis-peptide bond; other site
216595016241	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
216595016242	GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051
216595016243	putative C-terminal domain interface [polypeptide binding]; other site
216595016244	putative GSH binding site (G-site) [chemical binding]; other site
216595016245	putative dimer interface [polypeptide binding]; other site
216595016246	C-terminal, alpha helical domain of GTT2-like Glutathione S-transferases; Region: GST_C_GTT2_like; cd03182
216595016247	putative N-terminal domain interface [polypeptide binding]; other site
216595016248	putative dimer interface [polypeptide binding]; other site
216595016249	putative substrate binding pocket (H-site) [chemical binding]; other site
216595016252	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
216595016253	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216595016255	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
216595016257	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
216595016258	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
216595016259	Walker A/P-loop; other site
216595016260	ATP binding site [chemical binding]; other site
216595016261	Q-loop/lid; other site
216595016262	ABC transporter signature motif; other site
216595016263	Walker B; other site
216595016264	D-loop; other site
216595016265	H-loop/switch region; other site
216595016267	PS00017 ATP/GTP-binding site motif A (P-loop).
216595016268	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
216595016269	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
216595016270	TM-ABC transporter signature motif; other site
216595016271	8 probable transmembrane helices predicted for PFLU3421 by TMHMM2.0 at aa 5-27, 32-54, 59-78, 91-113, 141-158, 188-210, 225-247 and 254-276
216595016273	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
216595016274	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
216595016275	TM-ABC transporter signature motif; other site
216595016276	10 probable transmembrane helices predicted for PFLU3422 by TMHMM2.0 at aa 27-44, 48-70, 77-96, 101-123, 130-149, 182-200, 230-252, 267-285, 287-309 and 319-341
216595016278	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334
216595016279	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
216595016280	putative ligand binding site [chemical binding]; other site
216595016281	PS00037 Myb DNA-binding domain repeat signature 1.
216595016282	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
216595016283	nitrite reductase subunit NirD; Provisional; Region: PRK14989
216595016284	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
216595016285	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
216595016286	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
216595016287	active site
216595016289	PS00365 Nitrite and sulfite reductases iron-sulfur/siroheme-binding site.
216595016292	PS00022 EGF-like domain signature 1.
216595016296	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
216595016297	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
216595016298	[4Fe-4S] binding site [ion binding]; other site
216595016299	molybdopterin cofactor binding site; other site
216595016300	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
216595016301	molybdopterin cofactor binding site; other site
216595016302	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
216595016303	Flavodoxin; Region: Flavodoxin_1; pfam00258
216595016304	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
216595016305	FAD binding pocket [chemical binding]; other site
216595016306	FAD binding motif [chemical binding]; other site
216595016307	catalytic residues [active]
216595016308	NAD binding pocket [chemical binding]; other site
216595016309	phosphate binding motif [ion binding]; other site
216595016310	beta-alpha-beta structure motif; other site
216595016312	PS00551 Prokaryotic molybdopterin oxidoreductases signature 1.
216595016318	Cache domain; Region: Cache_1; pfam02743
216595016319	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
216595016320	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595016321	dimerization interface [polypeptide binding]; other site
216595016322	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595016323	dimer interface [polypeptide binding]; other site
216595016324	putative CheW interface [polypeptide binding]; other site
216595016325	2 probable transmembrane helices predicted for PFLU3427 by TMHMM2.0 at aa 7-29 and 290-312
216595016326	PS00017 ATP/GTP-binding site motif A (P-loop).
216595016330	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
216595016331	active site
216595016332	NTP binding site [chemical binding]; other site
216595016333	metal binding triad [ion binding]; metal-binding site
216595016335	AAA domain; Region: AAA_33; pfam13671
216595016336	PS00017 ATP/GTP-binding site motif A (P-loop).
216595016337	UV-endonuclease UvdE; Region: UvdE; cl10036
216595016339	4 probable transmembrane helices predicted for PFLU3431 by TMHMM2.0 at aa 50-72, 87-109, 121-140 and 150-172
216595016340	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
216595016341	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595016342	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595016343	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595016344	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
216595016345	dimerization interface [polypeptide binding]; other site
216595016348	PS00044 Bacterial regulatory proteins, lysR family signature.
216595016349	10 probable transmembrane helices predicted for PFLU3434 by TMHMM2.0 at aa 5-27, 37-56, 69-91, 96-115, 122-144, 154-174, 187-209, 229-251, 258-280 and 285-307
216595016350	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595016352	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
216595016353	MarR family; Region: MarR_2; pfam12802
216595016354	MarR family; Region: MarR_2; cl17246
216595016355	Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454
216595016356	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216595016357	Coenzyme A binding pocket [chemical binding]; other site
216595016360	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595016361	Major Facilitator Superfamily; Region: MFS_1; pfam07690
216595016362	putative substrate translocation pore; other site
216595016364	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
216595016365	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
216595016367	proline/glycine betaine transporter; Provisional; Region: PRK10642
216595016368	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595016369	putative substrate translocation pore; other site
216595016370	Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946
216595016372	12 probable transmembrane helices predicted for PFLU3438 by TMHMM2.0 at aa 48-70, 85-107, 116-138, 142-161, 182-204, 217-239, 278-300, 315-337, 344-364, 369-391, 404-426 and 436-455
216595016373	PS00216 Sugar transport proteins signature 1.
216595016375	GAF domain; Region: GAF; pfam01590
216595016376	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
216595016378	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
216595016379	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
216595016380	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595016382	PS00041 Bacterial regulatory proteins, araC family signature.
216595016384	PS00041 Bacterial regulatory proteins, araC family signature.
216595016386	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
216595016387	1 probable transmembrane helix predicted for PFLU3441 by TMHMM2.0 at aa 13-30
216595016388	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
216595016389	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595016390	putative substrate translocation pore; other site
216595016391	12 probable transmembrane helices predicted for PFLU3442 by TMHMM2.0 at aa 9-28, 48-70, 77-96, 101-123, 136-158, 163-185, 208-230, 240-262, 269-288, 298-320, 332-354 and 359-381
216595016393	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216595016394	active site
216595016395	CHASE4 domain; Region: CHASE4; pfam05228
216595016396	PAS domain S-box; Region: sensory_box; TIGR00229
216595016397	PAS domain; Region: PAS; smart00091
216595016398	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
216595016399	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216595016400	metal binding site [ion binding]; metal-binding site
216595016401	active site
216595016402	I-site; other site
216595016403	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
216595016404	2 probable transmembrane helices predicted for PFLU3444 by TMHMM2.0 at aa 25-47 and 261-283
216595016409	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
216595016410	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
216595016411	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595016413	PS00041 Bacterial regulatory proteins, araC family signature.
216595016416	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595016417	putative substrate translocation pore; other site
216595016418	Major Facilitator Superfamily; Region: MFS_1; pfam07690
216595016420	10 probable transmembrane helices predicted for PFLU3446 by TMHMM2.0 at aa 72-94, 109-131, 171-193, 198-220, 241-263, 283-305, 312-331, 335-357, 370-392 and 397-419
216595016421	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
216595016422	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595016423	dimer interface [polypeptide binding]; other site
216595016424	phosphorylation site [posttranslational modification]
216595016425	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595016426	ATP binding site [chemical binding]; other site
216595016427	Mg2+ binding site [ion binding]; other site
216595016428	G-X-G motif; other site
216595016431	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
216595016432	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216595016433	metal binding site [ion binding]; metal-binding site
216595016434	active site
216595016435	I-site; other site
216595016436	7 probable transmembrane helices predicted for PFLU3448 by TMHMM2.0 at aa 5-27, 34-56, 61-83, 90-107, 117-139, 152-174 and 184-206
216595016438	MAPEG family; Region: MAPEG; pfam01124
216595016440	PS00294 Prenyl group binding site (CAAX box).
216595016441	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
216595016442	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216595016443	non-specific DNA binding site [nucleotide binding]; other site
216595016444	salt bridge; other site
216595016445	sequence-specific DNA binding site [nucleotide binding]; other site
216595016447	amidase; Validated; Region: PRK06565
216595016448	Amidase; Region: Amidase; cl11426
216595016450	PS00017 ATP/GTP-binding site motif A (P-loop).
216595016451	CAAX protease self-immunity; Region: Abi; pfam02517
216595016453	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
216595016454	homotrimer interaction site [polypeptide binding]; other site
216595016455	putative active site [active]
216595016457	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
216595016458	Strictosidine synthase; Region: Str_synth; pfam03088
216595016460	SnoaL-like domain; Region: SnoaL_2; pfam12680
216595016461	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
216595016462	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595016463	DNA-binding site [nucleotide binding]; DNA binding site
216595016464	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216595016465	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595016466	homodimer interface [polypeptide binding]; other site
216595016467	catalytic residue [active]
216595016470	EamA-like transporter family; Region: EamA; pfam00892
216595016471	10 probable transmembrane helices predicted for PFLU3461 by TMHMM2.0 at aa 17-39, 43-65, 78-100, 105-124, 131-150, 160-177, 184-206, 216-238, 245-267 and 272-291
216595016474	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595016475	YceI-like domain; Region: YceI; smart00867
216595016477	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
216595016478	active site 2 [active]
216595016479	active site 1 [active]
216595016480	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
216595016481	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
216595016482	1 probable transmembrane helix predicted for PFLU3464 by TMHMM2.0 at aa 34-56
216595016484	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
216595016485	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
216595016486	PS00190 Cytochrome c family heme-binding site signature.
216595016487	Class II transport system: TRAP
216595016488	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
216595016489	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595016490	The C-terminal substrate-domain of LysR-type transcriptional regulators for beta-lactamase genes, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_beta_lactamase; cd08484
216595016491	putative dimerization interface [polypeptide binding]; other site
216595016492	putative substrate binding pocket [chemical binding]; other site
216595016495	PS00044 Bacterial regulatory proteins, lysR family signature.
216595016496	beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289
216595016497	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
216595016499	PS00336 Beta-lactamase class-C active site.
216595016500	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
216595016501	DctM-like transporters; Region: DctM; pfam06808
216595016502	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
216595016504	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
216595016506	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
216595016507	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
216595016509	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
216595016511	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
216595016512	CoA-transferase family III; Region: CoA_transf_3; pfam02515
216595016514	PS00017 ATP/GTP-binding site motif A (P-loop).
216595016515	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
216595016517	PS00017 ATP/GTP-binding site motif A (P-loop).
216595016518	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
216595016519	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
216595016520	active site
216595016522	PS00073 Acyl-CoA dehydrogenases signature 2.
216595016523	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595016526	Uncharacterized conserved protein [Function unknown]; Region: COG3777
216595016527	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
216595016528	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
216595016529	active site 2 [active]
216595016530	active site 1 [active]
216595016531	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595016532	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595016533	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
216595016534	putative dimerization interface [polypeptide binding]; other site
216595016536	PS00044 Bacterial regulatory proteins, lysR family signature.
216595016538	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595016539	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
216595016540	Walker A motif; other site
216595016541	ATP binding site [chemical binding]; other site
216595016542	Walker B motif; other site
216595016543	arginine finger; other site
216595016545	Uncharacterized conserved protein [Function unknown]; Region: COG3791
216595016547	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595016548	dimerization interface [polypeptide binding]; other site
216595016549	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595016550	dimer interface [polypeptide binding]; other site
216595016551	phosphorylation site [posttranslational modification]
216595016552	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595016553	ATP binding site [chemical binding]; other site
216595016554	Mg2+ binding site [ion binding]; other site
216595016555	G-X-G motif; other site
216595016559	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
216595016560	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595016561	active site
216595016562	phosphorylation site [posttranslational modification]
216595016563	intermolecular recognition site; other site
216595016564	dimerization interface [polypeptide binding]; other site
216595016565	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216595016566	DNA binding site [nucleotide binding]
216595016569	H+ Antiporter protein; Region: 2A0121; TIGR00900
216595016570	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595016571	putative substrate translocation pore; other site
216595016573	10 probable transmembrane helices predicted for PFLU3485 by TMHMM2.0 at aa 21-43, 53-72, 79-101, 157-174, 219-241, 251-270, 275-297, 301-323, 344-366 and 370-392
216595016574	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
216595016575	active site
216595016576	dinuclear metal binding site [ion binding]; other site
216595016577	dimerization interface [polypeptide binding]; other site
216595016579	universal stress protein UspE; Provisional; Region: PRK11175
216595016580	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
216595016581	Ligand Binding Site [chemical binding]; other site
216595016582	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
216595016583	Ligand Binding Site [chemical binding]; other site
216595016586	Predicted Fe-S protein [General function prediction only]; Region: COG3313
216595016588	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
216595016589	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
216595016590	substrate binding site [chemical binding]; other site
216595016591	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
216595016592	substrate binding site [chemical binding]; other site
216595016593	ligand binding site [chemical binding]; other site
216595016596	PS00450 Aconitase family signature 1.
216595016597	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
216595016598	serine transporter; Region: stp; TIGR00814
216595016600	Isochorismatase family; Region: Isochorismatase; pfam00857
216595016601	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
216595016602	catalytic triad [active]
216595016603	conserved cis-peptide bond; other site
216595016605	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
216595016606	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
216595016607	putative ligand binding site [chemical binding]; other site
216595016608	NAD binding site [chemical binding]; other site
216595016609	catalytic site [active]
216595016612	PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature.
216595016613	Phosphotransferase enzyme family; Region: APH; pfam01636
216595016614	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
216595016615	putative active site [active]
216595016616	putative substrate binding site [chemical binding]; other site
216595016617	ATP binding site [chemical binding]; other site
216595016619	PS00109 Tyrosine protein kinases specific active-site signature.
216595016620	short chain dehydrogenase; Provisional; Region: PRK07035
216595016621	classical (c) SDRs; Region: SDR_c; cd05233
216595016622	NAD(P) binding site [chemical binding]; other site
216595016623	active site
216595016625	PS00061 Short-chain dehydrogenases/reductases family signature.
216595016626	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
216595016627	Uncharacterized conserved protein [Function unknown]; Region: COG2128
216595016629	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
216595016630	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595016631	DNA-binding site [nucleotide binding]; DNA binding site
216595016632	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216595016633	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595016634	homodimer interface [polypeptide binding]; other site
216595016635	catalytic residue [active]
216595016638	Uncharacterized conserved protein [Function unknown]; Region: COG1359
216595016640	Cupin domain; Region: Cupin_2; pfam07883
216595016642	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
216595016644	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027
216595016645	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
216595016647	8 probable transmembrane helices predicted for PFLU3500 by TMHMM2.0 at aa 9-28, 48-65, 78-100, 154-176, 189-211, 226-248, 305-327 and 352-374
216595016648	PS00079 Multicopper oxidases signature 1.
216595016649	Transcriptional regulators [Transcription]; Region: FadR; COG2186
216595016650	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595016651	DNA-binding site [nucleotide binding]; DNA binding site
216595016652	FCD domain; Region: FCD; pfam07729
216595016654	PS00043 Bacterial regulatory proteins, gntR family signature.
216595016656	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595016657	DNA-binding site [nucleotide binding]; DNA binding site
216595016658	Transcriptional regulators [Transcription]; Region: GntR; COG1802
216595016659	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
216595016662	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
216595016664	MoxR-like ATPases [General function prediction only]; Region: COG0714
216595016665	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595016666	Walker A motif; other site
216595016667	ATP binding site [chemical binding]; other site
216595016668	Walker B motif; other site
216595016669	arginine finger; other site
216595016671	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
216595016672	Protein of unknown function DUF58; Region: DUF58; pfam01882
216595016674	Domain of unknown function (DUF4381); Region: DUF4381; pfam14316
216595016675	1 probable transmembrane helix predicted for PFLU3508 by TMHMM2.0 at aa 22-41
216595016676	PS00340 Growth factor and cytokines receptors family signature 2.
216595016677	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
216595016678	VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467
216595016679	metal ion-dependent adhesion site (MIDAS); other site
216595016681	1 probable transmembrane helix predicted for PFLU3509 by TMHMM2.0 at aa 301-320
216595016682	von Willebrand factor type A domain; Region: VWA_2; pfam13519
216595016683	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
216595016684	binding surface
216595016685	TPR motif; other site
216595016686	Tetratricopeptide repeat; Region: TPR_16; pfam13432
216595016687	2 probable transmembrane helices predicted for PFLU3510 by TMHMM2.0 at aa 10-29 and 62-81
216595016689	Oxygen tolerance; Region: BatD; pfam13584
216595016690	1 probable transmembrane helix predicted for PFLU3511 by TMHMM2.0 at aa 409-431
216595016691	exonuclease subunit SbcD; Provisional; Region: PRK10966
216595016692	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
216595016693	active site
216595016694	metal binding site [ion binding]; metal-binding site
216595016695	DNA binding site [nucleotide binding]
216595016696	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
216595016698	exonuclease subunit SbcC; Provisional; Region: PRK10246
216595016699	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216595016700	Walker A/P-loop; other site
216595016701	ATP binding site [chemical binding]; other site
216595016702	Q-loop/lid; other site
216595016703	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216595016704	ABC transporter signature motif; other site
216595016705	Walker B; other site
216595016706	D-loop; other site
216595016707	H-loop/switch region; other site
216595016709	PS00017 ATP/GTP-binding site motif A (P-loop).
216595016710	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
216595016711	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
216595016712	C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196
216595016713	putative N-terminal domain interface [polypeptide binding]; other site
216595016714	putative dimer interface [polypeptide binding]; other site
216595016715	putative substrate binding pocket (H-site) [chemical binding]; other site
216595016718	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
216595016719	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
216595016720	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
216595016727	1 probable transmembrane helix predicted for PFLU3522 by TMHMM2.0 at aa 24-46
216595016728	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
216595016729	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
216595016730	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
216595016734	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
216595016735	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
216595016736	acyl-activating enzyme (AAE) consensus motif; other site
216595016737	putative AMP binding site [chemical binding]; other site
216595016738	putative active site [active]
216595016739	putative CoA binding site [chemical binding]; other site
216595016741	PS00455 Putative AMP-binding domain signature.
216595016742	PS00044 Bacterial regulatory proteins, lysR family signature.
216595016743	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
216595016744	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
216595016745	dimer interface [polypeptide binding]; other site
216595016746	active site
216595016749	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
216595016750	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
216595016751	active site 2 [active]
216595016752	active site 1 [active]
216595016754	PS00639 Eukaryotic thiol (cysteine) proteases histidine active site.
216595016755	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
216595016756	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216595016757	NAD(P) binding site [chemical binding]; other site
216595016758	active site
216595016760	PS00061 Short-chain dehydrogenases/reductases family signature.
216595016761	acyl-CoA dehydrogenase; Reviewed; Region: PRK13026
216595016762	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
216595016763	active site
216595016764	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
216595016768	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349
216595016770	PS00037 Myb DNA-binding domain repeat signature 1.
216595016771	1 probable transmembrane helix predicted for PFLU3530 by TMHMM2.0 at aa 7-29
216595016772	1 probable transmembrane helix predicted for PFLU3531 by TMHMM2.0 at aa 7-29
216595016773	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349
216595016775	1 probable transmembrane helix predicted for PFLU3532 by TMHMM2.0 at aa 38-60
216595016776	1 probable transmembrane helix predicted for PFLU3533 by TMHMM2.0 at aa 7-29
216595016777	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
216595016778	Fatty acid desaturase; Region: FA_desaturase; pfam00487
216595016779	Di-iron ligands [ion binding]; other site
216595016781	PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.
216595016782	low G+C content region (38.07%)
216595016783	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
216595016785	1 probable transmembrane helix predicted for PFLU3536 by TMHMM2.0 at aa 43-65
216595016786	low G+C content region (36.6%)
216595016787	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
216595016788	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
216595016791	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216595016792	NAD(P) binding site [chemical binding]; other site
216595016793	short chain dehydrogenase; Provisional; Region: PRK07832
216595016794	active site
216595016796	PS00061 Short-chain dehydrogenases/reductases family signature.
216595016797	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
216595016798	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
216595016799	1 probable transmembrane helix predicted for PFLU3539 by TMHMM2.0 at aa 187-209
216595016800	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
216595016801	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
216595016802	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
216595016805	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
216595016806	Catalytic domain of Protein Kinases; Region: PKc; cd00180
216595016807	active site
216595016808	ATP binding site [chemical binding]; other site
216595016809	substrate binding site [chemical binding]; other site
216595016810	activation loop (A-loop); other site
216595016812	PS00108 Serine/Threonine protein kinases active-site signature.
216595016813	PS00107 Protein kinases ATP-binding region signature.
216595016814	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
216595016815	Protein phosphatase 2C; Region: PP2C; pfam00481
216595016816	active site
216595016818	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
216595016820	PS00017 ATP/GTP-binding site motif A (P-loop).
216595016821	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
216595016822	1 probable transmembrane helix predicted for PFLU3545 by TMHMM2.0 at aa 204-226
216595016823	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
216595016825	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
216595016826	Protein of unknown function (DUF877); Region: DUF877; pfam05943
216595016828	Protein of unknown function (DUF770); Region: DUF770; pfam05591
216595016830	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3515
216595016831	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
216595016832	type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362
216595016834	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
216595016836	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
216595016837	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
216595016838	active site
216595016839	catalytic tetrad [active]
216595016841	Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566
216595016843	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
216595016844	Repair protein; Region: Repair_PSII; pfam04536
216595016846	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
216595016847	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
216595016848	catalytic site [active]
216595016850	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
216595016851	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595016852	putative active site [active]
216595016853	heme pocket [chemical binding]; other site
216595016854	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595016855	dimer interface [polypeptide binding]; other site
216595016856	phosphorylation site [posttranslational modification]
216595016857	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595016858	ATP binding site [chemical binding]; other site
216595016859	Mg2+ binding site [ion binding]; other site
216595016860	G-X-G motif; other site
216595016864	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
216595016865	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
216595016866	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
216595016869	Predicted kinase [General function prediction only]; Region: COG0645
216595016870	AAA domain; Region: AAA_17; pfam13207
216595016872	PS00017 ATP/GTP-binding site motif A (P-loop).
216595016873	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
216595016874	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
216595016875	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
216595016877	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
216595016878	Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402
216595016880	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595016881	probable transmembrane helices predicted for PFLU3562 by TMHMM2.0 at aa 3-25
216595016882	glutathione S-transferase; Provisional; Region: PRK15113
216595016883	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
216595016884	C-terminal domain interface [polypeptide binding]; other site
216595016885	GSH binding site (G-site) [chemical binding]; other site
216595016886	dimer interface [polypeptide binding]; other site
216595016887	C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195
216595016888	putative dimer interface [polypeptide binding]; other site
216595016889	N-terminal domain interface [polypeptide binding]; other site
216595016890	putative substrate binding pocket (H-site) [chemical binding]; other site
216595016891	PS00092 N-6 Adenine-specific DNA methylases signature.
216595016893	Bacterial protein of unknown function (DUF924); Region: DUF924; cl01561
216595016895	Secretin and TonB N terminus short domain; Region: STN; smart00965
216595016896	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
216595016897	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216595016898	N-terminal plug; other site
216595016899	ligand-binding site [chemical binding]; other site
216595016901	PS01156 TonB-dependent receptor proteins signature 2.
216595016904	fec operon regulator FecR; Reviewed; Region: PRK09774
216595016905	FecR protein; Region: FecR; pfam04773
216595016907	RNA polymerase sigma factor; Provisional; Region: PRK12528
216595016908	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
216595016909	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
216595016910	DNA binding residues [nucleotide binding]
216595016913	Predicted membrane protein [Function unknown]; Region: COG3503
216595016914	9 probable transmembrane helices predicted for PFLU3569 by TMHMM2.0 at aa 61-83, 95-117, 123-145, 150-169, 202-219, 231-253, 276-298, 305-327 and 351-373
216595016915	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
216595016916	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
216595016917	THF binding site; other site
216595016918	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
216595016919	substrate binding site [chemical binding]; other site
216595016920	THF binding site; other site
216595016921	zinc-binding site [ion binding]; other site
216595016924	Cache domain; Region: Cache_1; pfam02743
216595016925	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
216595016926	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
216595016927	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216595016928	metal binding site [ion binding]; metal-binding site
216595016929	active site
216595016930	I-site; other site
216595016931	2 probable transmembrane helices predicted for PFLU3571 by TMHMM2.0 at aa 10-32 and 286-308
216595016934	outer membrane porin, OprD family; Region: OprD; pfam03573
216595016936	1 probable transmembrane helix predicted for PFLU3572 by TMHMM2.0 at aa 12-34
216595016937	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
216595016938	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
216595016939	active site
216595016940	metal binding site [ion binding]; metal-binding site
216595016941	hexamer interface [polypeptide binding]; other site
216595016943	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
216595016944	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216595016945	Walker A/P-loop; other site
216595016946	ATP binding site [chemical binding]; other site
216595016947	Q-loop/lid; other site
216595016948	ABC transporter signature motif; other site
216595016949	Walker B; other site
216595016950	D-loop; other site
216595016951	H-loop/switch region; other site
216595016952	TOBE domain; Region: TOBE_2; pfam08402
216595016955	PS00211 ABC transporters family signature.
216595016956	PS00017 ATP/GTP-binding site motif A (P-loop).
216595016957	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
216595016958	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595016959	dimer interface [polypeptide binding]; other site
216595016960	conserved gate region; other site
216595016961	putative PBP binding loops; other site
216595016962	ABC-ATPase subunit interface; other site
216595016964	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595016965	dimer interface [polypeptide binding]; other site
216595016966	conserved gate region; other site
216595016967	putative PBP binding loops; other site
216595016968	ABC-ATPase subunit interface; other site
216595016970	2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046
216595016971	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
216595016972	Transcriptional regulators [Transcription]; Region: PurR; COG1609
216595016973	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
216595016974	DNA binding site [nucleotide binding]
216595016975	Ligand-binding domain of putative DNA transcription repressors highly similar to that of the repressor specific for gluconate (GntR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_2; cd06282
216595016976	putative ligand binding site [chemical binding]; other site
216595016977	putative dimerization interface [polypeptide binding]; other site
216595016980	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
216595016981	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
216595016982	dimer interface [polypeptide binding]; other site
216595016983	active site
216595016984	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
216595016985	catalytic residues [active]
216595016986	substrate binding site [chemical binding]; other site
216595016987	PS00017 ATP/GTP-binding site motif A (P-loop).
216595016989	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
216595016990	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
216595016991	NAD(P) binding pocket [chemical binding]; other site
216595016993	PS00017 ATP/GTP-binding site motif A (P-loop).
216595016994	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
216595016995	Transcriptional regulator [Transcription]; Region: IclR; COG1414
216595016996	Bacterial transcriptional regulator; Region: IclR; pfam01614
216595016999	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
216595017000	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595017001	substrate binding pocket [chemical binding]; other site
216595017002	membrane-bound complex binding site; other site
216595017003	hinge residues; other site
216595017005	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595017006	dimer interface [polypeptide binding]; other site
216595017007	conserved gate region; other site
216595017008	putative PBP binding loops; other site
216595017009	ABC-ATPase subunit interface; other site
216595017011	5 probable transmembrane helices predicted for PFLU3583 by TMHMM2.0 at aa 23-45, 58-80, 85-104, 138-157 and 187-209
216595017012	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595017013	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
216595017014	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
216595017015	Walker A/P-loop; other site
216595017016	ATP binding site [chemical binding]; other site
216595017017	Q-loop/lid; other site
216595017018	ABC transporter signature motif; other site
216595017019	Walker B; other site
216595017020	D-loop; other site
216595017021	H-loop/switch region; other site
216595017022	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
216595017024	PS00017 ATP/GTP-binding site motif A (P-loop).
216595017025	PS00211 ABC transporters family signature.
216595017026	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
216595017027	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
216595017028	PS00043 Bacterial regulatory proteins, gntR family signature.
216595017030	glutaminase; Provisional; Region: PRK00971
216595017031	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
216595017033	Cupin domain; Region: Cupin_2; cl17218
216595017034	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
216595017036	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
216595017037	B1 nucleotide binding pocket [chemical binding]; other site
216595017038	B2 nucleotide binding pocket [chemical binding]; other site
216595017039	CAS motifs; other site
216595017040	active site
216595017042	PS00531 Ribonuclease T2 family histidine active site 2.
216595017043	PS00530 Ribonuclease T2 family histidine active site 1.
216595017044	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
216595017045	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
216595017046	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
216595017048	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595017050	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667
216595017051	nudix motif; other site
216595017053	PS00893 mutT domain signature.
216595017054	Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200
216595017055	outer membrane porin, OprD family; Region: OprD; pfam03573
216595017057	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
216595017058	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
216595017060	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
216595017061	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
216595017062	TPP-binding site [chemical binding]; other site
216595017063	dimer interface [polypeptide binding]; other site
216595017064	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
216595017065	PYR/PP interface [polypeptide binding]; other site
216595017066	dimer interface [polypeptide binding]; other site
216595017067	TPP binding site [chemical binding]; other site
216595017068	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
216595017070	PS00801 Transketolase signature 1.
216595017072	PS00802 Transketolase signature 2.
216595017074	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
216595017075	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
216595017076	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
216595017077	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
216595017079	PS00211 ABC transporters family signature.
216595017080	PS00017 ATP/GTP-binding site motif A (P-loop).
216595017081	PS00211 ABC transporters family signature.
216595017082	PS00017 ATP/GTP-binding site motif A (P-loop).
216595017083	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595017084	dimer interface [polypeptide binding]; other site
216595017085	phosphorylation site [posttranslational modification]
216595017086	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595017087	ATP binding site [chemical binding]; other site
216595017088	G-X-G motif; other site
216595017089	Response regulator receiver domain; Region: Response_reg; pfam00072
216595017090	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595017091	active site
216595017092	phosphorylation site [posttranslational modification]
216595017093	intermolecular recognition site; other site
216595017094	dimerization interface [polypeptide binding]; other site
216595017099	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
216595017100	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
216595017101	putative active site [active]
216595017102	putative PHP Thumb interface [polypeptide binding]; other site
216595017103	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
216595017104	generic binding surface I; other site
216595017105	generic binding surface II; other site
216595017109	DNA Polymerase Y-family; Region: PolY_like; cd03468
216595017110	active site
216595017111	DNA binding site [nucleotide binding]
216595017112	Uncharacterized conserved protein [Function unknown]; Region: COG4544
216595017113	LexA repressor; Provisional; Region: PRK12423
216595017114	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
216595017115	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
216595017116	Catalytic site [active]
216595017119	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
216595017120	RHS Repeat; Region: RHS_repeat; cl11982
216595017121	RHS Repeat; Region: RHS_repeat; cl11982
216595017122	RHS Repeat; Region: RHS_repeat; cl11982
216595017123	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
216595017124	RHS Repeat; Region: RHS_repeat; pfam05593
216595017125	RHS Repeat; Region: RHS_repeat; pfam05593
216595017126	RHS Repeat; Region: RHS_repeat; cl11982
216595017127	RHS Repeat; Region: RHS_repeat; pfam05593
216595017128	RHS protein; Region: RHS; pfam03527
216595017129	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
216595017130	Pertussis toxin, subunit 1; Region: Pertussis_S1; cl03779
216595017145	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
216595017146	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
216595017147	dimer interface [polypeptide binding]; other site
216595017148	ADP-ribose binding site [chemical binding]; other site
216595017149	active site
216595017150	nudix motif; other site
216595017151	metal binding site [ion binding]; metal-binding site
216595017153	PS00017 ATP/GTP-binding site motif A (P-loop).
216595017154	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
216595017155	classical (c) SDRs; Region: SDR_c; cd05233
216595017156	NAD(P) binding site [chemical binding]; other site
216595017157	active site
216595017159	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
216595017160	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
216595017161	1 probable transmembrane helix predicted for PFLU3610 by TMHMM2.0 at aa 13-35
216595017163	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
216595017164	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
216595017165	phosphate binding site [ion binding]; other site
216595017167	PS00557 FMN-dependent alpha-hydroxy acid dehydrogenases active site.
216595017168	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
216595017169	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
216595017170	putative DNA binding site [nucleotide binding]; other site
216595017171	putative Zn2+ binding site [ion binding]; other site
216595017172	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
216595017174	PS00894 Bacterial regulatory proteins, deoR family signature.
216595017176	PS00141 Eukaryotic and viral aspartyl proteases active site.
216595017177	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
216595017178	intracellular protease, PfpI family; Region: PfpI; TIGR01382
216595017179	proposed catalytic triad [active]
216595017180	conserved cys residue [active]
216595017182	PS00017 ATP/GTP-binding site motif A (P-loop).
216595017183	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
216595017184	Hemerythrin-like domain; Region: Hr-like; cd12108
216595017187	1 probable transmembrane helix predicted for PFLU3618 by TMHMM2.0 at aa 9-28
216595017188	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
216595017189	HemN C-terminal domain; Region: HemN_C; pfam06969
216595017191	AZL_007950 family protein; Region: AZL_007950_fam; TIGR04061
216595017192	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
216595017193	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
216595017194	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
216595017195	Cu(I) binding site [ion binding]; other site
216595017196	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595017198	Protein of unknown function (DUF461); Region: DUF461; pfam04314
216595017200	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
216595017201	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216595017202	Coenzyme A binding pocket [chemical binding]; other site
216595017204	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
216595017205	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216595017206	Coenzyme A binding pocket [chemical binding]; other site
216595017208	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216595017209	Coenzyme A binding pocket [chemical binding]; other site
216595017211	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216595017212	Coenzyme A binding pocket [chemical binding]; other site
216595017214	RNA polymerase sigma factor FecI; Provisional; Region: PRK09651
216595017215	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
216595017216	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
216595017217	DNA binding residues [nucleotide binding]
216595017220	fec operon regulator FecR; Reviewed; Region: PRK09774
216595017221	FecR protein; Region: FecR; pfam04773
216595017223	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
216595017224	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216595017225	N-terminal plug; other site
216595017226	ligand-binding site [chemical binding]; other site
216595017230	PS01156 TonB-dependent receptor proteins signature 2.
216595017231	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
216595017232	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595017233	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
216595017234	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595017236	PS00011 Vitamin K-dependent carboxylation domain.
216595017238	PS00041 Bacterial regulatory proteins, araC family signature.
216595017240	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
216595017242	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
216595017244	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
216595017245	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
216595017247	1 probable transmembrane helix predicted for PFLU3637 by TMHMM2.0 at aa 15-37
216595017248	Predicted transcriptional regulator [Transcription]; Region: COG1959
216595017249	Transcriptional regulator; Region: Rrf2; pfam02082
216595017250	Transcriptional regulator; Region: Rrf2; cl17282
216595017252	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
216595017253	Mechanosensitive ion channel; Region: MS_channel; pfam00924
216595017254	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
216595017255	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
216595017256	ligand binding site [chemical binding]; other site
216595017259	Pirin-related protein [General function prediction only]; Region: COG1741
216595017260	Pirin; Region: Pirin; pfam02678
216595017261	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
216595017264	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
216595017265	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595017266	active site
216595017267	phosphorylation site [posttranslational modification]
216595017268	intermolecular recognition site; other site
216595017269	dimerization interface [polypeptide binding]; other site
216595017270	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216595017271	DNA binding site [nucleotide binding]
216595017274	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595017275	dimerization interface [polypeptide binding]; other site
216595017276	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595017277	dimer interface [polypeptide binding]; other site
216595017278	phosphorylation site [posttranslational modification]
216595017279	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595017280	ATP binding site [chemical binding]; other site
216595017281	Mg2+ binding site [ion binding]; other site
216595017282	G-X-G motif; other site
216595017283	1 probable transmembrane helix predicted for PFLU3642 by TMHMM2.0 at aa 13-35
216595017287	enterobactin receptor protein; Provisional; Region: PRK13483
216595017288	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216595017289	N-terminal plug; other site
216595017290	ligand-binding site [chemical binding]; other site
216595017292	PS01156 TonB-dependent receptor proteins signature 2.
216595017294	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
216595017295	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
216595017296	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595017297	putative substrate translocation pore; other site
216595017299	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
216595017300	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
216595017301	HlyD family secretion protein; Region: HlyD_3; pfam13437
216595017303	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
216595017304	Protein export membrane protein; Region: SecD_SecF; cl14618
216595017306	12 probable transmembrane helices predicted for PFLU3646 by TMHMM2.0 at aa 13-32, 341-358, 360-382, 392-414, 427-449, 464-486, 527-546, 858-877, 884-906, 910-932, 962-984 and 989-1011
216595017307	low G+C content region (41.32%)
216595017308	glutamate carboxypeptidase; Reviewed; Region: PRK06133
216595017309	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
216595017310	metal binding site [ion binding]; metal-binding site
216595017311	dimer interface [polypeptide binding]; other site
216595017314	PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1.
216595017315	1 probable transmembrane helix predicted for PFLU3649 by TMHMM2.0 at aa 13-35
216595017316	MASE2 domain; Region: MASE2; pfam05230
216595017317	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
216595017318	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216595017319	metal binding site [ion binding]; metal-binding site
216595017320	active site
216595017321	I-site; other site
216595017324	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
216595017326	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595017327	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
216595017328	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595017329	DNA-binding site [nucleotide binding]; DNA binding site
216595017330	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216595017331	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595017332	homodimer interface [polypeptide binding]; other site
216595017333	catalytic residue [active]
216595017336	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
216595017337	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595017338	active site
216595017339	phosphorylation site [posttranslational modification]
216595017340	intermolecular recognition site; other site
216595017341	dimerization interface [polypeptide binding]; other site
216595017342	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216595017343	DNA binding site [nucleotide binding]
216595017346	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
216595017347	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
216595017348	dimer interface [polypeptide binding]; other site
216595017349	phosphorylation site [posttranslational modification]
216595017350	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595017351	ATP binding site [chemical binding]; other site
216595017352	Mg2+ binding site [ion binding]; other site
216595017353	G-X-G motif; other site
216595017354	2 probable transmembrane helices predicted for PFLU3654 by TMHMM2.0 at aa 15-37 and 157-179
216595017358	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
216595017359	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216595017360	DNA binding site [nucleotide binding]
216595017362	PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1.
216595017363	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
216595017364	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216595017365	DNA binding site [nucleotide binding]
216595017367	PFI-9
216595017368	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
216595017369	Bacterial sugar transferase; Region: Bac_transf; pfam02397
216595017370	5 probable transmembrane helices predicted for PFLU3658 by TMHMM2.0 at aa 23-45, 55-74, 86-108, 118-140 and 290-309
216595017372	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
216595017374	Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251
216595017376	1 probable transmembrane helix predicted for PFLU3660 by TMHMM2.0 at aa 7-29
216595017377	Protein of unknown function (DUF2886); Region: DUF2886; pfam11102
216595017378	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595017379	polysaccharide export protein Wza; Provisional; Region: PRK15078
216595017380	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
216595017382	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
216595017383	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
216595017384	Substrate binding site; other site
216595017385	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
216595017388	GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430
216595017389	active site
216595017390	GDP-Mannose binding site [chemical binding]; other site
216595017391	dimer interface [polypeptide binding]; other site
216595017392	modified nudix motif
216595017393	metal binding site [ion binding]; metal-binding site
216595017395	putative glycosyl transferase; Provisional; Region: PRK10307
216595017396	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
216595017398	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
216595017399	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
216595017400	NADP binding site [chemical binding]; other site
216595017401	active site
216595017402	putative substrate binding site [chemical binding]; other site
216595017404	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
216595017405	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
216595017406	NADP-binding site; other site
216595017407	homotetramer interface [polypeptide binding]; other site
216595017408	substrate binding site [chemical binding]; other site
216595017409	homodimer interface [polypeptide binding]; other site
216595017410	active site
216595017412	PS00061 Short-chain dehydrogenases/reductases family signature.
216595017413	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
216595017414	putative metal binding site; other site
216595017416	putative acyl transferase; Provisional; Region: PRK10502
216595017417	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
216595017418	putative trimer interface [polypeptide binding]; other site
216595017419	putative active site [active]
216595017420	putative substrate binding site [chemical binding]; other site
216595017421	putative CoA binding site [chemical binding]; other site
216595017426	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
216595017427	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
216595017428	putative ADP-binding pocket [chemical binding]; other site
216595017430	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
216595017431	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
216595017433	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
216595017434	trimer interface [polypeptide binding]; other site
216595017435	active site
216595017436	substrate binding site [chemical binding]; other site
216595017437	CoA binding site [chemical binding]; other site
216595017438	PS00101 Hexapeptide-repeat containing-transferases signature.
216595017442	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
216595017443	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082
216595017444	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
216595017445	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
216595017446	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
216595017447	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
216595017451	tyrosine kinase; Provisional; Region: PRK11519
216595017452	Chain length determinant protein; Region: Wzz; pfam02706
216595017453	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
216595017454	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
216595017455	P loop; other site
216595017456	Nucleotide binding site [chemical binding]; other site
216595017457	DTAP/Switch II; other site
216595017458	Switch I; other site
216595017460	Low molecular weight phosphatase family; Region: LMWPc; cd00115
216595017461	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
216595017462	active site
216595017464	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
216595017465	active site
216595017466	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
216595017467	active site
216595017468	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
216595017469	dimer interface [polypeptide binding]; other site
216595017470	non-prolyl cis peptide bond; other site
216595017471	insertion regions; other site
216595017473	PS00012 Phosphopantetheine attachment site.
216595017474	aldolase II superfamily protein; Provisional; Region: PRK07044
216595017475	active site
216595017476	intersubunit interface [polypeptide binding]; other site
216595017477	Zn2+ binding site [ion binding]; other site
216595017479	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595017480	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595017481	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
216595017482	dimerization interface [polypeptide binding]; other site
216595017485	PS00044 Bacterial regulatory proteins, lysR family signature.
216595017486	low G+C content region (40.35%)
216595017487	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
216595017489	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
216595017490	active site residue [active]
216595017491	Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533
216595017492	active site residue [active]
216595017493	Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534
216595017494	active site residue [active]
216595017495	Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535
216595017496	active site residue [active]
216595017498	PS00380 Rhodanese signature 1.
216595017499	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
216595017500	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595017501	substrate binding pocket [chemical binding]; other site
216595017502	membrane-bound complex binding site; other site
216595017504	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
216595017505	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
216595017506	active site
216595017507	non-prolyl cis peptide bond; other site
216595017508	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
216595017509	putative catalytic residues [active]
216595017511	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
216595017512	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
216595017513	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
216595017516	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_15; cd12180
216595017517	putative ligand binding site [chemical binding]; other site
216595017518	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
216595017519	putative NAD binding site [chemical binding]; other site
216595017520	catalytic site [active]
216595017523	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
216595017525	1 probable transmembrane helix predicted for PFLU3694 by TMHMM2.0 at aa 21-43
216595017526	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
216595017527	TolR protein; Region: tolR; TIGR02801
216595017529	1 probable transmembrane helix predicted for PFLU3695 by TMHMM2.0 at aa 17-39
216595017530	TolQ protein; Region: tolQ; TIGR02796
216595017532	Phytase; Region: Phytase; cl17685
216595017533	Phytase; Region: Phytase; cl17685
216595017535	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
216595017536	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
216595017537	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216595017540	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
216595017541	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216595017542	metal binding site [ion binding]; metal-binding site
216595017543	active site
216595017544	I-site; other site
216595017545	3 probable transmembrane helices predicted for PFLU3699 by TMHMM2.0 at aa 12-29, 39-61 and 68-86
216595017547	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
216595017548	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
216595017550	LysR family transcriptional regulator; Provisional; Region: PRK14997
216595017551	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595017552	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
216595017553	putative effector binding pocket; other site
216595017554	dimerization interface [polypeptide binding]; other site
216595017557	PS00044 Bacterial regulatory proteins, lysR family signature.
216595017558	Isochorismatase family; Region: Isochorismatase; pfam00857
216595017559	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
216595017560	catalytic triad [active]
216595017561	dimer interface [polypeptide binding]; other site
216595017562	conserved cis-peptide bond; other site
216595017564	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
216595017565	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
216595017566	active site
216595017568	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
216595017570	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595017571	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595017572	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464
216595017573	putative substrate binding pocket [chemical binding]; other site
216595017574	putative dimerization interface [polypeptide binding]; other site
216595017578	PS00041 Bacterial regulatory proteins, araC family signature.
216595017580	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
216595017581	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216595017582	DNA binding site [nucleotide binding]
216595017583	AAA ATPase domain; Region: AAA_16; pfam13191
216595017584	Predicted ATPase [General function prediction only]; Region: COG3903
216595017586	PS00017 ATP/GTP-binding site motif A (P-loop).
216595017587	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
216595017588	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216595017589	DNA binding site [nucleotide binding]
216595017590	Predicted ATPase [General function prediction only]; Region: COG3903
216595017591	AAA domain; Region: AAA_17; pfam13207
216595017592	PS00017 ATP/GTP-binding site motif A (P-loop).
216595017594	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
216595017595	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
216595017596	conserved cys residue [active]
216595017597	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595017598	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595017602	Pirin-related protein [General function prediction only]; Region: COG1741
216595017603	Pirin; Region: Pirin; pfam02678
216595017605	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
216595017606	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
216595017607	conserved cys residue [active]
216595017608	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595017609	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595017611	PS00041 Bacterial regulatory proteins, araC family signature.
216595017614	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
216595017615	active site
216595017616	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
216595017617	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
216595017618	Walker A/P-loop; other site
216595017619	ATP binding site [chemical binding]; other site
216595017620	Q-loop/lid; other site
216595017621	ABC transporter signature motif; other site
216595017622	Walker B; other site
216595017623	D-loop; other site
216595017624	H-loop/switch region; other site
216595017626	PS00211 ABC transporters family signature.
216595017627	PS00017 ATP/GTP-binding site motif A (P-loop).
216595017628	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595017629	putative PBP binding loops; other site
216595017630	dimer interface [polypeptide binding]; other site
216595017631	ABC-ATPase subunit interface; other site
216595017633	NMT1-like family; Region: NMT1_2; pfam13379
216595017634	NMT1/THI5 like; Region: NMT1; pfam09084
216595017636	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
216595017637	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
216595017638	active site
216595017639	non-prolyl cis peptide bond; other site
216595017641	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
216595017642	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595017643	substrate binding pocket [chemical binding]; other site
216595017644	membrane-bound complex binding site; other site
216595017645	hinge residues; other site
216595017647	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
216595017648	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595017649	substrate binding pocket [chemical binding]; other site
216595017650	membrane-bound complex binding site; other site
216595017652	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
216595017653	bacterial glycerol kinase 2-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK2_bacteria; cd07791
216595017654	N- and C-terminal domain interface [polypeptide binding]; other site
216595017655	active site
216595017656	MgATP binding site [chemical binding]; other site
216595017657	catalytic site [active]
216595017658	metal binding site [ion binding]; metal-binding site
216595017659	putative homotetramer interface [polypeptide binding]; other site
216595017660	putative homodimer interface [polypeptide binding]; other site
216595017661	glycerol binding site [chemical binding]; other site
216595017663	PS00445 FGGY family of carbohydrate kinases signature 2.
216595017665	PS00933 FGGY family of carbohydrate kinases signature 1.
216595017666	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
216595017667	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
216595017668	PYR/PP interface [polypeptide binding]; other site
216595017669	dimer interface [polypeptide binding]; other site
216595017670	TPP binding site [chemical binding]; other site
216595017671	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
216595017674	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
216595017675	TPP-binding site [chemical binding]; other site
216595017676	dimer interface [polypeptide binding]; other site
216595017678	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
216595017679	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
216595017680	TM-ABC transporter signature motif; other site
216595017681	8 probable transmembrane helices predicted for PFLU3726 by TMHMM2.0 at aa 29-51, 63-80, 84-101, 108-130, 176-198, 228-250, 265-295 and 302-324
216595017683	PS00027 'Homeobox' domain signature.
216595017684	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
216595017685	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
216595017686	ligand binding site [chemical binding]; other site
216595017688	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
216595017689	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
216595017690	Walker A/P-loop; other site
216595017691	ATP binding site [chemical binding]; other site
216595017692	Q-loop/lid; other site
216595017693	ABC transporter signature motif; other site
216595017694	Walker B; other site
216595017695	D-loop; other site
216595017696	H-loop/switch region; other site
216595017697	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
216595017699	PS00017 ATP/GTP-binding site motif A (P-loop).
216595017701	PS00211 ABC transporters family signature.
216595017702	short chain dehydrogenase; Provisional; Region: PRK06114
216595017703	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216595017704	NAD(P) binding site [chemical binding]; other site
216595017705	active site
216595017707	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
216595017708	PS00061 Short-chain dehydrogenases/reductases family signature.
216595017709	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
216595017710	meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366
216595017711	NAD binding site [chemical binding]; other site
216595017712	homotetramer interface [polypeptide binding]; other site
216595017713	homodimer interface [polypeptide binding]; other site
216595017714	active site
216595017715	substrate binding site [chemical binding]; other site
216595017717	PS00061 Short-chain dehydrogenases/reductases family signature.
216595017718	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
216595017719	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
216595017720	DNA binding residues [nucleotide binding]
216595017721	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
216595017723	transaldolase-like protein; Provisional; Region: PTZ00411
216595017724	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
216595017725	active site
216595017726	dimer interface [polypeptide binding]; other site
216595017727	catalytic residue [active]
216595017729	PS01054 Transaldolase signature 1.
216595017730	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
216595017731	amphipathic channel; other site
216595017732	Asn-Pro-Ala signature motifs; other site
216595017734	PS00221 MIP family signature.
216595017735	putative arabinose transporter; Provisional; Region: PRK03545
216595017736	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595017737	putative substrate translocation pore; other site
216595017739	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
216595017740	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
216595017741	PS00904 Protein prenyltransferases alpha subunit repeat signature.
216595017743	Cupin domain; Region: Cupin_2; cl17218
216595017744	Helix-turn-helix domain; Region: HTH_18; pfam12833
216595017745	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595017747	PS00041 Bacterial regulatory proteins, araC family signature.
216595017749	Major Facilitator Superfamily; Region: MFS_1; pfam07690
216595017750	12 probable transmembrane helices predicted for PFLU3738 by TMHMM2.0 at aa 13-35, 45-67, 74-96, 101-123, 144-161, 166-188, 231-253, 263-282, 295-314, 318-340, 353-375 and 385-407
216595017752	PS00017 ATP/GTP-binding site motif A (P-loop).
216595017753	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
216595017754	NMT1-like family; Region: NMT1_2; pfam13379
216595017755	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
216595017757	Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928
216595017758	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
216595017759	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595017760	dimer interface [polypeptide binding]; other site
216595017761	conserved gate region; other site
216595017762	putative PBP binding loops; other site
216595017763	ABC-ATPase subunit interface; other site
216595017765	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595017766	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
216595017767	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595017768	putative PBP binding loops; other site
216595017769	dimer interface [polypeptide binding]; other site
216595017770	ABC-ATPase subunit interface; other site
216595017772	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
216595017773	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
216595017774	Walker A/P-loop; other site
216595017775	ATP binding site [chemical binding]; other site
216595017776	Q-loop/lid; other site
216595017777	ABC transporter signature motif; other site
216595017778	Walker B; other site
216595017779	D-loop; other site
216595017780	H-loop/switch region; other site
216595017781	TOBE domain; Region: TOBE_2; pfam08402
216595017784	PS00017 ATP/GTP-binding site motif A (P-loop).
216595017785	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
216595017786	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
216595017787	Walker A/P-loop; other site
216595017788	ATP binding site [chemical binding]; other site
216595017789	Q-loop/lid; other site
216595017790	ABC transporter signature motif; other site
216595017791	Walker B; other site
216595017792	D-loop; other site
216595017793	H-loop/switch region; other site
216595017794	TOBE domain; Region: TOBE_2; pfam08402
216595017797	PS00017 ATP/GTP-binding site motif A (P-loop).
216595017798	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
216595017799	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595017800	Walker A motif; other site
216595017801	ATP binding site [chemical binding]; other site
216595017802	Walker B motif; other site
216595017803	arginine finger; other site
216595017804	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
216595017805	DNA-binding interface [nucleotide binding]; DNA binding site
216595017808	PS00675 Sigma-54 interaction domain ATP-binding region A signature.
216595017809	PS00676 Sigma-54 interaction domain ATP-binding region B signature.
216595017811	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
216595017812	FecR protein; Region: FecR; pfam04773
216595017814	1 probable transmembrane helix predicted for PFLU3748 by TMHMM2.0 at aa 80-102
216595017815	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
216595017816	PS00173 Xylose isomerase signature 2.
216595017817	RNA polymerase sigma factor; Provisional; Region: PRK12528
216595017818	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
216595017819	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
216595017820	DNA binding residues [nucleotide binding]
216595017824	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
216595017825	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
216595017826	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
216595017829	low G+C content region (40%)
216595017830	1 probable transmembrane helix predicted for PFLU3752 by TMHMM2.0 at aa 21-43
216595017831	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216595017832	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
216595017833	non-specific DNA binding site [nucleotide binding]; other site
216595017834	salt bridge; other site
216595017835	sequence-specific DNA binding site [nucleotide binding]; other site
216595017836	Cupin domain; Region: Cupin_2; pfam07883
216595017841	PAS domain S-box; Region: sensory_box; TIGR00229
216595017842	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595017843	putative active site [active]
216595017844	heme pocket [chemical binding]; other site
216595017845	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
216595017846	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216595017847	metal binding site [ion binding]; metal-binding site
216595017848	active site
216595017849	I-site; other site
216595017852	low G+C content region (47.9%)
216595017853	Helix-turn-helix domain; Region: HTH_18; pfam12833
216595017854	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595017855	DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449
216595017857	PS00041 Bacterial regulatory proteins, araC family signature.
216595017860	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
216595017861	catalytic site [active]
216595017862	metal binding site [ion binding]; metal-binding site
216595017863	gcgggnnnncccgc
216595017864	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
216595017865	YccA-like proteins; Region: YccA_like; cd10433
216595017867	7 probable transmembrane helices predicted for PFLU3767 by TMHMM2.0 at aa 22-44, 49-68, 75-97, 107-129, 136-158, 162-181 and 194-216
216595017868	PS01243 Uncharacterized protein family UPF0005 signature.
216595017869	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
216595017870	FAD binding domain; Region: FAD_binding_4; pfam01565
216595017871	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
216595017874	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
216595017875	Low molecular weight phosphatase family; Region: LMWPc; cd00115
216595017876	active site
216595017878	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
216595017879	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
216595017880	Ligand binding site; other site
216595017881	oligomer interface; other site
216595017883	Uncharacterized conserved protein [Function unknown]; Region: COG2835
216595017885	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
216595017886	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
216595017888	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
216595017889	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
216595017891	1 probable transmembrane helix predicted for PFLU3773 by TMHMM2.0 at aa 13-35
216595017892	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
216595017894	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
216595017895	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
216595017896	Competence protein; Region: Competence; pfam03772
216595017897	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
216595017898	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
216595017901	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3216
216595017902	3 probable transmembrane helices predicted for PFLU3776 by TMHMM2.0 at aa 47-69, 82-104 and 137-159
216595017903	hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107
216595017904	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595017905	dimerization interface [polypeptide binding]; other site
216595017906	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595017907	dimer interface [polypeptide binding]; other site
216595017908	phosphorylation site [posttranslational modification]
216595017909	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595017910	ATP binding site [chemical binding]; other site
216595017911	Mg2+ binding site [ion binding]; other site
216595017912	G-X-G motif; other site
216595017913	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595017914	active site
216595017915	phosphorylation site [posttranslational modification]
216595017916	intermolecular recognition site; other site
216595017917	dimerization interface [polypeptide binding]; other site
216595017918	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
216595017919	putative binding surface; other site
216595017920	active site
216595017921	2 probable transmembrane helices predicted for PFLU3777 by TMHMM2.0 at aa 10-32 and 169-191
216595017927	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
216595017928	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
216595017929	putative ligand binding site [chemical binding]; other site
216595017930	putative NAD binding site [chemical binding]; other site
216595017931	catalytic site [active]
216595017934	PS00017 ATP/GTP-binding site motif A (P-loop).
216595017935	PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature.
216595017936	PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2.
216595017937	PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3.
216595017938	META domain; Region: META; pfam03724
216595017939	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595017941	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
216595017942	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
216595017943	catalytic residues [active]
216595017945	PS00194 Thioredoxin family active site.
216595017946	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595017947	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
216595017948	ArsC family; Region: ArsC; pfam03960
216595017949	catalytic residues [active]
216595017951	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
216595017952	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
216595017954	Predicted membrane protein [Function unknown]; Region: COG3308
216595017955	4 probable transmembrane helices predicted for PFLU3784 by TMHMM2.0 at aa 20-42, 52-74, 79-96 and 100-122
216595017956	3-methyladenine DNA glycosylase [DNA replication, recombination, and repair]; Region: Tag; COG2818
216595017958	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
216595017959	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
216595017960	Ligand Binding Site [chemical binding]; other site
216595017962	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
216595017963	6 probable transmembrane helices predicted for PFLU3787 by TMHMM2.0 at aa 15-37, 63-85, 100-122, 135-154, 158-180 and 193-215
216595017965	hypothetical protein; Provisional; Region: PRK04860
216595017966	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
216595017968	PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.
216595017969	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
216595017970	CoA-transferase family III; Region: CoA_transf_3; pfam02515
216595017972	sulfur transfer complex subunit TusD; Validated; Region: PRK00207
216595017974	sulfur relay protein TusC; Validated; Region: PRK00211
216595017976	sulfur relay protein TusB/DsrH; Region: sulf_tusB_dsrH; TIGR03011
216595017978	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
216595017979	sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342
216595017981	hypothetical protein; Validated; Region: PRK09071
216595017982	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
216595017983	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
216595017985	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
216595017986	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
216595017987	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
216595017988	putative dimer interface [polypeptide binding]; other site
216595017989	N-terminal domain interface [polypeptide binding]; other site
216595017990	putative substrate binding pocket (H-site) [chemical binding]; other site
216595017992	siroheme synthase; Provisional; Region: cysG; PRK10637
216595017993	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
216595017994	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
216595017995	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
216595017996	active site
216595017997	SAM binding site [chemical binding]; other site
216595017998	homodimer interface [polypeptide binding]; other site
216595018000	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595018001	PS00840 Uroporphyrin-III C-methyltransferase signature 2.
216595018002	seryl-tRNA synthetase; Provisional; Region: PRK05431
216595018003	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
216595018004	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
216595018005	dimer interface [polypeptide binding]; other site
216595018006	active site
216595018007	motif 1; other site
216595018008	motif 2; other site
216595018009	motif 3; other site
216595018011	PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1.
216595018013	camphor resistance protein CrcB; Provisional; Region: PRK14234
216595018015	recombination factor protein RarA; Reviewed; Region: PRK13342
216595018016	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595018017	Walker A motif; other site
216595018018	ATP binding site [chemical binding]; other site
216595018019	Walker B motif; other site
216595018020	arginine finger; other site
216595018021	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
216595018023	PS00017 ATP/GTP-binding site motif A (P-loop).
216595018024	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
216595018025	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
216595018027	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
216595018028	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
216595018029	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
216595018031	PS00017 ATP/GTP-binding site motif A (P-loop).
216595018032	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
216595018034	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
216595018035	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
216595018036	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
216595018039	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
216595018040	rRNA binding site [nucleotide binding]; other site
216595018041	predicted 30S ribosome binding site; other site
216595018043	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
216595018044	Clp amino terminal domain; Region: Clp_N; pfam02861
216595018045	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595018046	Walker A motif; other site
216595018047	ATP binding site [chemical binding]; other site
216595018048	Walker B motif; other site
216595018049	arginine finger; other site
216595018050	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595018051	Walker A motif; other site
216595018052	ATP binding site [chemical binding]; other site
216595018053	Walker B motif; other site
216595018054	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
216595018055	PS00024 Hemopexin domain signature.
216595018057	PS00871 Chaperonins clpA/B signature 2.
216595018058	PS00017 ATP/GTP-binding site motif A (P-loop).
216595018060	PS00870 Chaperonins clpA/B signature 1.
216595018061	PS00017 ATP/GTP-binding site motif A (P-loop).
216595018063	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
216595018065	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
216595018066	DNA-binding site [nucleotide binding]; DNA binding site
216595018067	RNA-binding motif; other site
216595018069	PS00352 'Cold-shock' DNA-binding domain signature.
216595018070	isocitrate dehydrogenase; Validated; Region: PRK07362
216595018071	isocitrate dehydrogenase; Reviewed; Region: PRK07006
216595018073	PS00470 Isocitrate and isopropylmalate dehydrogenases signature.
216595018074	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
216595018075	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
216595018078	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
216595018079	nudix motif; other site
216595018081	PS00893 mutT domain signature.
216595018082	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
216595018083	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
216595018085	PS00070 Aldehyde dehydrogenases cysteine active site.
216595018086	putative lysogenization regulator; Reviewed; Region: PRK00218
216595018088	adenylosuccinate lyase; Provisional; Region: PRK09285
216595018089	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
216595018090	tetramer interface [polypeptide binding]; other site
216595018091	active site
216595018093	PS00163 Fumarate lyases signature.
216595018095	Uncharacterized conserved protein [Function unknown]; Region: COG2850
216595018097	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
216595018098	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216595018099	Coenzyme A binding pocket [chemical binding]; other site
216595018101	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
216595018102	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
216595018104	isocitrate lyase; Provisional; Region: PRK15063
216595018105	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
216595018106	tetramer interface [polypeptide binding]; other site
216595018107	active site
216595018108	Mg2+/Mn2+ binding site [ion binding]; other site
216595018110	PS00161 Isocitrate lyase signature.
216595018111	low G+C content region (44.58%)
216595018112	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
216595018113	3 probable transmembrane helices predicted for PFLU3818 by TMHMM2.0 at aa 40-62, 92-114 and 124-146
216595018115	NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377
216595018117	PS01150 Respiratory-chain NADH dehydrogenase 20 Kd subunit signature.
216595018118	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
216595018119	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
216595018120	NADH dehydrogenase subunit D; Validated; Region: PRK06075
216595018122	PS00535 Respiratory chain NADH dehydrogenase 49 Kd subunit signature.
216595018124	NADH dehydrogenase subunit E; Validated; Region: PRK07539
216595018125	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
216595018126	putative dimer interface [polypeptide binding]; other site
216595018127	[2Fe-2S] cluster binding site [ion binding]; other site
216595018129	PS01099 Respiratory-chain NADH dehydrogenase 24 Kd subunit signature.
216595018130	NADH dehydrogenase I subunit F; Provisional; Region: PRK11278
216595018131	SLBB domain; Region: SLBB; pfam10531
216595018132	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
216595018134	PS00644 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1.
216595018135	PS00645 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2.
216595018136	PS00017 ATP/GTP-binding site motif A (P-loop).
216595018137	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
216595018138	NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973
216595018139	catalytic loop [active]
216595018140	iron binding site [ion binding]; other site
216595018141	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
216595018142	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
216595018143	[4Fe-4S] binding site [ion binding]; other site
216595018144	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
216595018146	PS00641 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1.
216595018147	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595018148	PS00642 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2.
216595018149	PS00643 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3.
216595018152	PS00490 Prokaryotic molybdopterin oxidoreductases signature 2.
216595018153	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
216595018154	8 probable transmembrane helices predicted for PFLU3824 by TMHMM2.0 at aa 13-35, 81-103, 115-137, 152-174, 187-209, 239-261, 273-295 and 305-327
216595018156	PS00668 Respiratory-chain NADH dehydrogenase subunit 1 signature 2.
216595018157	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
216595018158	4Fe-4S binding domain; Region: Fer4; pfam00037
216595018159	4Fe-4S binding domain; Region: Fer4; pfam00037
216595018161	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
216595018163	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
216595018164	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
216595018165	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
216595018166	5 probable transmembrane helices predicted for PFLU3826 by TMHMM2.0 at aa 5-22, 29-51, 56-78, 91-113 and 138-160
216595018168	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
216595018169	3 probable transmembrane helices predicted for PFLU3827 by TMHMM2.0 at aa 5-27, 32-54 and 64-86
216595018171	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
216595018172	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
216595018173	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
216595018174	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
216595018175	17 probable transmembrane helices predicted for PFLU3828 by TMHMM2.0 at aa 4-21, 28-50, 86-108, 115-134, 138-160, 173-195, 215-237, 250-269, 279-301, 308-330, 334-356, 377-399, 414-436, 456-478, 498-517, 529-548 and 594-616
216595018178	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
216595018179	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
216595018180	13 probable transmembrane helices predicted for PFLU3829 by TMHMM2.0 at aa 2-20, 30-47, 82-104, 114-133, 140-162, 177-199, 223-245, 287-309, 316-333, 343-365, 378-400, 420-442 and 463-485
216595018182	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
216595018183	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
216595018184	14 probable transmembrane helices predicted for PFLU3830 by TMHMM2.0 at aa 29-51, 58-80, 95-117, 130-147, 151-173, 185-207, 227-249, 261-283, 293-315, 322-341, 351-373, 394-416, 431-453 and 474-493
216595018186	Protein of unknown function (DUF1044); Region: DUF1044; cl01955
216595018187	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
216595018188	non-specific DNA binding site [nucleotide binding]; other site
216595018189	salt bridge; other site
216595018190	sequence-specific DNA binding site [nucleotide binding]; other site
216595018191	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
216595018192	N-acetyltransferase; Region: Acetyltransf_2; pfam00797
216595018194	Protein of unknown function (DUF3087); Region: DUF3087; pfam11286
216595018195	2 probable transmembrane helices predicted for PFLU3838 by TMHMM2.0 at aa 31-53 and 63-84
216595018197	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595018198	Major Facilitator Superfamily; Region: MFS_1; pfam07690
216595018199	putative substrate translocation pore; other site
216595018201	Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048
216595018202	ggaaccnnnnnnnnnnnnnnnnccacnna
216595018203	Dyp-type peroxidase family; Region: Dyp_perox_fam; TIGR01413
216595018205	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
216595018206	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
216595018207	tetrameric interface [polypeptide binding]; other site
216595018208	activator binding site; other site
216595018209	NADP binding site [chemical binding]; other site
216595018210	substrate binding site [chemical binding]; other site
216595018211	catalytic residues [active]
216595018213	PS00070 Aldehyde dehydrogenases cysteine active site.
216595018214	Predicted membrane protein [Function unknown]; Region: COG1289
216595018215	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
216595018216	4 probable transmembrane helices predicted for PFLU3845 by TMHMM2.0 at aa 27-49, 97-119, 124-141 and 156-178
216595018217	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
216595018218	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216595018220	low G+C conent region (50.14%)
216595018221	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
216595018222	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
216595018223	Walker A/P-loop; other site
216595018224	ATP binding site [chemical binding]; other site
216595018225	Q-loop/lid; other site
216595018226	ABC transporter signature motif; other site
216595018227	Walker B; other site
216595018228	D-loop; other site
216595018229	H-loop/switch region; other site
216595018231	PS00017 ATP/GTP-binding site motif A (P-loop).
216595018232	PS00211 ABC transporters family signature.
216595018233	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
216595018234	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
216595018235	FtsX-like permease family; Region: FtsX; pfam02687
216595018236	4 probable transmembrane helices predicted for PFLU3848 by TMHMM2.0 at aa 33-55, 279-301, 329-351 and 366-388
216595018238	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
216595018241	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
216595018242	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
216595018243	HlyD family secretion protein; Region: HlyD_3; pfam13437
216595018244	1 probable transmembrane helix predicted for PFLU3850 by TMHMM2.0 at aa 7-24
216595018246	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
216595018247	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
216595018248	PS00215 Mitochondrial energy transfer proteins signature.
216595018250	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
216595018251	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
216595018252	Walker A/P-loop; other site
216595018253	ATP binding site [chemical binding]; other site
216595018254	Q-loop/lid; other site
216595018255	ABC transporter signature motif; other site
216595018256	Walker B; other site
216595018257	D-loop; other site
216595018258	H-loop/switch region; other site
216595018260	PS00017 ATP/GTP-binding site motif A (P-loop).
216595018261	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334
216595018262	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
216595018263	putative ligand binding site [chemical binding]; other site
216595018264	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
216595018265	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
216595018266	TM-ABC transporter signature motif; other site
216595018268	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
216595018269	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
216595018270	TM-ABC transporter signature motif; other site
216595018272	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
216595018273	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
216595018274	Walker A/P-loop; other site
216595018275	ATP binding site [chemical binding]; other site
216595018276	Q-loop/lid; other site
216595018277	ABC transporter signature motif; other site
216595018278	Walker B; other site
216595018279	D-loop; other site
216595018280	H-loop/switch region; other site
216595018282	PS00017 ATP/GTP-binding site motif A (P-loop).
216595018283	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
216595018284	atcgggggcaagccccctcccaca
216595018285	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
216595018286	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
216595018287	active site
216595018288	non-prolyl cis peptide bond; other site
216595018289	atcgggggcaagccccctcccaca
216595018290	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
216595018291	active site
216595018292	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
216595018293	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
216595018294	Flavin binding site [chemical binding]; other site
216595018297	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216595018298	non-specific DNA binding site [nucleotide binding]; other site
216595018299	salt bridge; other site
216595018300	sequence-specific DNA binding site [nucleotide binding]; other site
216595018301	Cupin domain; Region: Cupin_2; pfam07883
216595018304	EamA-like transporter family; Region: EamA; pfam00892
216595018305	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
216595018306	10 probable transmembrane helices predicted for PFLU3862 by TMHMM2.0 at aa 55-77, 81-100, 113-135, 140-159, 164-186, 196-217, 224-246, 250-272, 285-302 and 306-323
216595018309	19 probable transmembrane helices predicted for PFLU3863 by TMHMM2.0 at aa 2-24, 34-56, 77-99, 109-126, 133-152, 162-184, 204-226, 241-263, 270-292, 307-329, 363-385, 405-427, 459-481, 501-523, 574-596, 602-624, 631-653, 657-679 and 700-722
216595018312	5 probable transmembrane helices predicted for PFLU3864 by TMHMM2.0 at aa 15-32, 77-96, 106-128, 141-163 and 183-205
216595018314	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094
216595018316	3 probable transmembrane helices predicted for PFLU3865 by TMHMM2.0 at aa 4-21, 28-50 and 75-97
216595018317	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
216595018318	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
216595018319	14 probable transmembrane helices predicted for PFLU3866 by TMHMM2.0 at aa 7-26, 36-55, 85-107, 122-144, 165-187, 214-236, 243-265, 280-302, 309-328, 332-354, 401-423, 427-449, 456-478 and 493-512
216595018321	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
216595018322	2 probable transmembrane helices predicted for PFLU3867 by TMHMM2.0 at aa 7-26 and 30-52
216595018324	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161
216595018325	3 probable transmembrane helices predicted for PFLU3868 by TMHMM2.0 at aa 5-27, 37-59 and 66-88
216595018327	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583
216595018329	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
216595018330	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
216595018331	NADP+ binding site [chemical binding]; other site
216595018332	folate binding site [chemical binding]; other site
216595018334	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
216595018335	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
216595018336	active site
216595018337	HIGH motif; other site
216595018338	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
216595018339	KMSKS motif; other site
216595018340	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
216595018341	tRNA binding surface [nucleotide binding]; other site
216595018342	anticodon binding site; other site
216595018345	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
216595018346	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
216595018347	active site
216595018348	HIGH motif; other site
216595018349	nucleotide binding site [chemical binding]; other site
216595018350	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
216595018351	KMSKS motif; other site
216595018352	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
216595018355	PS00178 Aminoacyl-transfer RNA synthetases class-I signature.
216595018356	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
216595018357	substrate binding site [chemical binding]; other site
216595018359	PS00170 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature.
216595018360	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
216595018361	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
216595018362	putative active site [active]
216595018363	putative metal binding site [ion binding]; other site
216595018365	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
216595018366	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595018367	putative substrate translocation pore; other site
216595018368	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595018370	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595018371	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
216595018372	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
216595018373	HlyD family secretion protein; Region: HlyD_3; pfam13437
216595018375	PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature.
216595018376	1 probable transmembrane helix predicted for PFLU3876 by TMHMM2.0 at aa 24-43
216595018377	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
216595018379	PS00216 Sugar transport proteins signature 1.
216595018381	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595018382	MarR family; Region: MarR_2; cl17246
216595018383	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
216595018385	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
216595018386	Family of unknown function (DUF490); Region: DUF490; pfam04357
216595018387	Family of unknown function (DUF490); Region: DUF490; pfam04357
216595018389	1 probable transmembrane helix predicted for PFLU3879 by TMHMM2.0 at aa 7-29
216595018390	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
216595018391	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
216595018392	Surface antigen; Region: Bac_surface_Ag; pfam01103
216595018395	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595018396	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
216595018398	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
216595018399	putative catalytic site [active]
216595018400	putative phosphate binding site [ion binding]; other site
216595018401	active site
216595018402	metal binding site A [ion binding]; metal-binding site
216595018403	DNA binding site [nucleotide binding]
216595018404	putative AP binding site [nucleotide binding]; other site
216595018405	putative metal binding site B [ion binding]; other site
216595018407	PS00726 AP endonucleases family 1 signature 1.
216595018408	PS00727 AP endonucleases family 1 signature 2.
216595018409	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
216595018410	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
216595018411	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
216595018412	ligand binding site [chemical binding]; other site
216595018413	1 probable transmembrane helix predicted for PFLU3883 by TMHMM2.0 at aa 5-24
216595018414	PS00017 ATP/GTP-binding site motif A (P-loop).
216595018416	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
216595018417	Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155
216595018418	FAD binding site [chemical binding]; other site
216595018419	substrate binding site [chemical binding]; other site
216595018420	catalytic base [active]
216595018423	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
216595018424	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595018425	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
216595018426	substrate binding pocket [chemical binding]; other site
216595018427	dimerization interface [polypeptide binding]; other site
216595018429	PS00044 Bacterial regulatory proteins, lysR family signature.
216595018431	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
216595018432	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
216595018433	DNA binding residues [nucleotide binding]
216595018434	putative dimer interface [polypeptide binding]; other site
216595018436	PS00552 Bacterial regulatory proteins, merR family signature.
216595018438	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
216595018439	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
216595018440	active site
216595018441	catalytic residues [active]
216595018442	metal binding site [ion binding]; metal-binding site
216595018444	low G+C content region (39.66%)
216595018445	AMP-binding domain protein; Validated; Region: PRK08315
216595018446	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
216595018447	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
216595018448	acyl-activating enzyme (AAE) consensus motif; other site
216595018449	acyl-activating enzyme (AAE) consensus motif; other site
216595018450	putative AMP binding site [chemical binding]; other site
216595018451	putative active site [active]
216595018452	putative CoA binding site [chemical binding]; other site
216595018454	PS00455 Putative AMP-binding domain signature.
216595018455	isovaleryl-CoA dehydrogenase; Region: PLN02519
216595018456	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
216595018457	substrate binding site [chemical binding]; other site
216595018458	FAD binding site [chemical binding]; other site
216595018459	catalytic base [active]
216595018462	PS00072 Acyl-CoA dehydrogenases signature 1.
216595018464	PS00073 Acyl-CoA dehydrogenases signature 2.
216595018465	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
216595018466	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
216595018467	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
216595018469	gamma-carboxygeranoyl-CoA hydratase; Validated; Region: PRK05674
216595018470	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
216595018471	substrate binding site [chemical binding]; other site
216595018472	oxyanion hole (OAH) forming residues; other site
216595018473	trimer interface [polypeptide binding]; other site
216595018475	PS00166 Enoyl-CoA hydratase/isomerase signature.
216595018476	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
216595018477	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
216595018478	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
216595018479	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
216595018480	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
216595018481	carboxyltransferase (CT) interaction site; other site
216595018482	biotinylation site [posttranslational modification]; other site
216595018485	PS00866 Carbamoyl-phosphate synthase subdomain signature 1.
216595018486	PS00867 Carbamoyl-phosphate synthase subdomain signature 2.
216595018489	PS00188 Biotin-requiring enzymes attachment site.
216595018490	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216595018491	salt bridge; other site
216595018492	non-specific DNA binding site [nucleotide binding]; other site
216595018493	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
216595018494	sequence-specific DNA binding site [nucleotide binding]; other site
216595018495	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
216595018496	Catalytic site [active]
216595018499	very low G+C content region (39.65%)
216595018500	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
216595018501	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
216595018502	active site
216595018503	Zn binding site [ion binding]; other site
216595018505	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
216595018507	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
216595018508	putative heme binding pocket [chemical binding]; other site
216595018510	1 probable transmembrane helix predicted for PFLU3897 by TMHMM2.0 at aa 16-38
216595018511	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
216595018512	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
216595018513	DNA binding residues [nucleotide binding]
216595018516	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
216595018517	1 probable transmembrane helix predicted for PFLU3899 by TMHMM2.0 at aa 83-105
216595018518	Spore Coat Protein U domain; Region: SCPU; pfam05229
216595018519	Spore Coat Protein U domain; Region: SCPU; pfam05229
216595018520	putative pili subunits-related proteins
216595018523	1 probable transmembrane helix predicted for PFLU3900 by TMHMM2.0 at aa 7-29
216595018524	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
216595018525	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
216595018526	PapC C-terminal domain; Region: PapC_C; pfam13953
216595018528	PS01151 Fimbrial biogenesis outer membrane usher protein signature.
216595018529	1 probable transmembrane helix predicted for PFLU3901 by TMHMM2.0 at aa 20-39
216595018530	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
216595018531	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
216595018532	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595018533	Spore Coat Protein U domain; Region: SCPU; pfam05229
216595018535	Spore Coat Protein U domain; Region: SCPU; pfam05229
216595018537	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595018538	Spore Coat Protein U domain; Region: SCPU; pfam05229
216595018540	Spore Coat Protein U domain; Region: SCPU; pfam05229
216595018542	Predicted ATPase [General function prediction only]; Region: COG1485
216595018543	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595018544	Walker A motif; other site
216595018545	ATP binding site [chemical binding]; other site
216595018546	Walker B motif; other site
216595018547	arginine finger; other site
216595018549	PS00017 ATP/GTP-binding site motif A (P-loop).
216595018550	Leucine rich repeat; Region: LRR_8; pfam13855
216595018551	Leucine rich repeat; Region: LRR_8; pfam13855
216595018552	Catalytic domain of Protein Kinases; Region: PKc; cd00180
216595018553	active site
216595018554	ATP binding site [chemical binding]; other site
216595018555	substrate binding site [chemical binding]; other site
216595018556	activation loop (A-loop); other site
216595018562	PS00107 Protein kinases ATP-binding region signature.
216595018563	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595018564	hypothetical protein; Provisional; Region: PRK12378
216595018566	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595018567	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
216595018568	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
216595018569	dimerization interface [polypeptide binding]; other site
216595018572	PS00044 Bacterial regulatory proteins, lysR family signature.
216595018573	2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479
216595018574	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
216595018575	catalytic residue [active]
216595018577	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
216595018578	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216595018579	motif II; other site
216595018581	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
216595018583	4 probable transmembrane helices predicted for PFLU3913 by TMHMM2.0 at aa 20-37, 52-74, 95-117 and 155-174
216595018584	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595018585	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
216595018586	catalytic residue [active]
216595018587	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
216595018588	PS00687 Aldehyde dehydrogenases glutamic acid active site.
216595018589	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
216595018590	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
216595018591	active site
216595018592	FMN binding site [chemical binding]; other site
216595018593	2,4-decadienoyl-CoA binding site; other site
216595018594	catalytic residue [active]
216595018595	4Fe-4S cluster binding site [ion binding]; other site
216595018596	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
216595018597	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
216595018601	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
216595018602	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
216595018603	active site
216595018604	catalytic triad [active]
216595018605	Predicted amidohydrolase [General function prediction only]; Region: COG0388
216595018606	dimer interface [polypeptide binding]; other site
216595018607	1 probable transmembrane helix predicted for PFLU3916 by TMHMM2.0 at aa 27-46
216595018609	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
216595018610	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
216595018612	2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012
216595018614	MarR family; Region: MarR_2; pfam12802
216595018616	PS01117 Bacterial regulatory proteins, marR family signature.
216595018617	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
216595018618	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
216595018619	dimer interface [polypeptide binding]; other site
216595018620	TPP-binding site [chemical binding]; other site
216595018621	Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001
216595018622	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595018623	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595018624	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595018625	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476
216595018626	putative effector binding pocket; other site
216595018627	putative dimerization interface [polypeptide binding]; other site
216595018630	PS00044 Bacterial regulatory proteins, lysR family signature.
216595018631	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595018632	Major Facilitator Superfamily; Region: MFS_1; pfam07690
216595018633	putative substrate translocation pore; other site
216595018634	12 probable transmembrane helices predicted for PFLU3923 by TMHMM2.0 at aa 58-80, 95-117, 124-146, 151-170, 183-205, 209-231, 266-288, 293-312, 319-338, 342-361, 381-403 and 407-424
216595018637	periplasmic folding chaperone; Provisional; Region: PRK10788
216595018638	SurA N-terminal domain; Region: SurA_N_3; pfam13624
216595018639	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
216595018640	PS00017 ATP/GTP-binding site motif A (P-loop).
216595018642	PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature.
216595018644	1 probable transmembrane helix predicted for PFLU3925 by TMHMM2.0 at aa 12-34
216595018645	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
216595018646	IHF - DNA interface [nucleotide binding]; other site
216595018647	IHF dimer interface [polypeptide binding]; other site
216595018649	PS00045 Bacterial histone-like DNA-binding proteins signature.
216595018650	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
216595018651	Found in ATP-dependent protease La (LON); Region: LON; smart00464
216595018652	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595018653	Walker A motif; other site
216595018654	ATP binding site [chemical binding]; other site
216595018655	Walker B motif; other site
216595018656	arginine finger; other site
216595018657	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
216595018660	PS00017 ATP/GTP-binding site motif A (P-loop).
216595018662	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
216595018663	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
216595018664	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595018665	Walker A motif; other site
216595018666	ATP binding site [chemical binding]; other site
216595018667	Walker B motif; other site
216595018668	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
216595018670	PS00017 ATP/GTP-binding site motif A (P-loop).
216595018672	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
216595018673	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
216595018674	oligomer interface [polypeptide binding]; other site
216595018675	active site residues [active]
216595018677	PS00382 Endopeptidase Clp histidine active site.
216595018678	PS00381 Endopeptidase Clp serine active site.
216595018679	trigger factor; Provisional; Region: tig; PRK01490
216595018680	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
216595018681	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
216595018685	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
216595018686	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
216595018687	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
216595018688	homodimer interface [polypeptide binding]; other site
216595018689	NADP binding site [chemical binding]; other site
216595018690	substrate binding site [chemical binding]; other site
216595018691	PS00017 ATP/GTP-binding site motif A (P-loop).
216595018694	D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669
216595018695	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
216595018697	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
216595018698	putative active site [active]
216595018699	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595018700	1 probable transmembrane helix predicted for PFLU3934 by TMHMM2.0 at aa 21-43
216595018701	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595018702	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
216595018704	10 probable transmembrane helices predicted for PFLU3936 by TMHMM2.0 at aa 21-40, 369-391, 442-464, 469-488, 570-589, 911-933, 940-959, 969-991, 1011-1033 and 1043-1065
216595018705	PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide.
216595018706	PS00138 Serine proteases, subtilase family, serine active site.
216595018707	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
216595018708	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
216595018709	HlyD family secretion protein; Region: HlyD_3; pfam13437
216595018710	1 probable transmembrane helix predicted for PFLU3937 by TMHMM2.0 at aa 12-31
216595018712	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
216595018713	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595018716	Transposase IS200 like; Region: Y1_Tnp; pfam01797
216595018718	allantoate amidohydrolase; Reviewed; Region: PRK12893
216595018719	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
216595018720	active site
216595018721	metal binding site [ion binding]; metal-binding site
216595018722	dimer interface [polypeptide binding]; other site
216595018725	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485
216595018726	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
216595018727	Na binding site [ion binding]; other site
216595018728	putative substrate binding site [chemical binding]; other site
216595018730	low G+C content region (45.1%)
216595018731	phenylhydantoinase; Validated; Region: PRK08323
216595018732	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
216595018733	tetramer interface [polypeptide binding]; other site
216595018734	active site
216595018736	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
216595018737	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
216595018739	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
216595018740	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
216595018741	homodimer interface [polypeptide binding]; other site
216595018742	active site
216595018743	FMN binding site [chemical binding]; other site
216595018744	substrate binding site [chemical binding]; other site
216595018745	4Fe-4S binding domain; Region: Fer4; cl02805
216595018748	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
216595018750	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
216595018751	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
216595018752	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216595018753	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
216595018756	CopC domain; Region: CopC; pfam04234
216595018758	Copper resistance protein D; Region: CopD; cl00563
216595018760	8 probable transmembrane helices predicted for PFLU3947 by TMHMM2.0 at aa 10-32, 48-70, 90-109, 114-136, 146-168, 181-203, 218-240 and 260-282
216595018761	outer membrane porin, OprD family; Region: OprD; pfam03573
216595018763	PS00309 Galaptin signature.
216595018764	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
216595018765	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216595018766	active site
216595018768	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
216595018770	Class II transport system: TRAP
216595018771	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
216595018772	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
216595018774	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
216595018775	4 probable transmembrane helices predicted for PFLU3952 by TMHMM2.0 at aa 28-50, 65-82, 103-122 and 145-167
216595018777	DctM-like transporters; Region: DctM; pfam06808
216595018778	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
216595018779	11 probable transmembrane helices predicted for PFLU3953 by TMHMM2.0 at aa 5-27, 42-64, 77-99, 171-193, 217-239, 243-257, 277-299, 314-331, 336-353, 363-385 and 397-419
216595018781	aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021
216595018782	active site
216595018783	catalytic residues [active]
216595018785	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
216595018786	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
216595018787	HlyD family secretion protein; Region: HlyD_3; pfam13437
216595018789	1 probable transmembrane helix predicted for PFLU3955 by TMHMM2.0 at aa 12-34
216595018790	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595018791	putative substrate translocation pore; other site
216595018793	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
216595018794	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
216595018795	transmembrane helices; other site
216595018797	PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature.
216595018798	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
216595018800	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
216595018802	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
216595018804	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
216595018805	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595018806	dimerization interface [polypeptide binding]; other site
216595018807	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
216595018808	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595018809	dimer interface [polypeptide binding]; other site
216595018810	putative CheW interface [polypeptide binding]; other site
216595018813	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
216595018814	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
216595018815	putative DNA binding site [nucleotide binding]; other site
216595018816	putative Zn2+ binding site [ion binding]; other site
216595018817	AsnC family; Region: AsnC_trans_reg; pfam01037
216595018819	PS00519 Bacterial regulatory proteins, asnC family signature.
216595018820	2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573
216595018821	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
216595018822	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
216595018823	tetramer interface [polypeptide binding]; other site
216595018824	TPP-binding site [chemical binding]; other site
216595018825	heterodimer interface [polypeptide binding]; other site
216595018826	phosphorylation loop region [posttranslational modification]
216595018828	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
216595018829	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
216595018830	alpha subunit interface [polypeptide binding]; other site
216595018831	TPP binding site [chemical binding]; other site
216595018832	heterodimer interface [polypeptide binding]; other site
216595018833	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
216595018836	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
216595018837	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
216595018838	E3 interaction surface; other site
216595018839	lipoyl attachment site [posttranslational modification]; other site
216595018840	e3 binding domain; Region: E3_binding; pfam02817
216595018841	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
216595018845	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
216595018846	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
216595018847	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
216595018849	PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site.
216595018850	PS00017 ATP/GTP-binding site motif A (P-loop).
216595018852	PS00017 ATP/GTP-binding site motif A (P-loop).
216595018854	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
216595018855	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
216595018856	homodimer interface [polypeptide binding]; other site
216595018857	substrate-cofactor binding pocket; other site
216595018858	catalytic residue [active]
216595018860	PS00770 Aminotransferases class-IV signature.
216595018861	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
216595018862	putative acetyltransferase; Provisional; Region: PRK03624
216595018863	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216595018864	Coenzyme A binding pocket [chemical binding]; other site
216595018867	ornithine cyclodeaminase; Validated; Region: PRK07589
216595018868	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
216595018870	PS00017 ATP/GTP-binding site motif A (P-loop).
216595018871	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
216595018872	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
216595018873	AsnC family; Region: AsnC_trans_reg; pfam01037
216595018875	Transposase; Region: DEDD_Tnp_IS110; pfam01548
216595018876	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
216595018877	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
216595018880	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
216595018881	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
216595018882	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216595018883	FeS/SAM binding site; other site
216595018885	L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434
216595018886	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
216595018887	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
216595018888	RNA polymerase sigma factor; Reviewed; Region: PRK12527
216595018889	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
216595018890	DNA binding residues [nucleotide binding]
216595018893	macrolide transporter subunit MacA; Provisional; Region: PRK11578
216595018894	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
216595018895	HlyD family secretion protein; Region: HlyD_3; pfam13437
216595018896	1 probable transmembrane helix predicted for PFLU3977 by TMHMM2.0 at aa 41-60
216595018898	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
216595018899	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
216595018900	Walker A/P-loop; other site
216595018901	ATP binding site [chemical binding]; other site
216595018902	Q-loop/lid; other site
216595018903	ABC transporter signature motif; other site
216595018904	Walker B; other site
216595018905	D-loop; other site
216595018906	H-loop/switch region; other site
216595018907	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
216595018908	FtsX-like permease family; Region: FtsX; pfam02687
216595018910	PS00017 ATP/GTP-binding site motif A (P-loop).
216595018911	PS00211 ABC transporters family signature.
216595018912	4 probable transmembrane helices predicted for PFLU3978 by TMHMM2.0 at aa 283-305, 531-553, 588-610 and 617-639
216595018914	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
216595018915	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595018918	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
216595018920	Transcriptional regulators [Transcription]; Region: FadR; COG2186
216595018921	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595018922	DNA-binding site [nucleotide binding]; DNA binding site
216595018923	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
216595018926	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
216595018927	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
216595018928	putative ligand binding site [chemical binding]; other site
216595018929	PS00294 Prenyl group binding site (CAAX box).
216595018930	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
216595018931	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
216595018932	TM-ABC transporter signature motif; other site
216595018934	8 probable transmembrane helices predicted for PFLU3983 by TMHMM2.0 at aa 15-33, 35-57, 62-84, 96-118, 138-160, 189-211, 226-248 and 255-277
216595018935	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
216595018936	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
216595018937	TM-ABC transporter signature motif; other site
216595018938	9 probable transmembrane helices predicted for PFLU3984 by TMHMM2.0 at aa 16-38, 42-64, 66-83, 87-109, 114-136, 166-188, 219-241, 256-278 and 291-313
216595018940	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
216595018941	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
216595018942	Walker A/P-loop; other site
216595018943	ATP binding site [chemical binding]; other site
216595018944	Q-loop/lid; other site
216595018945	ABC transporter signature motif; other site
216595018946	Walker B; other site
216595018947	D-loop; other site
216595018948	H-loop/switch region; other site
216595018950	PS00017 ATP/GTP-binding site motif A (P-loop).
216595018951	PS00211 ABC transporters family signature.
216595018952	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
216595018953	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
216595018954	Walker A/P-loop; other site
216595018955	ATP binding site [chemical binding]; other site
216595018956	Q-loop/lid; other site
216595018957	ABC transporter signature motif; other site
216595018958	Walker B; other site
216595018959	D-loop; other site
216595018960	H-loop/switch region; other site
216595018962	PS00017 ATP/GTP-binding site motif A (P-loop).
216595018963	PS00211 ABC transporters family signature.
216595018964	allantoate amidohydrolase; Reviewed; Region: PRK12893
216595018965	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
216595018966	active site
216595018967	metal binding site [ion binding]; metal-binding site
216595018968	dimer interface [polypeptide binding]; other site
216595018971	putative amidase; Provisional; Region: PRK06169
216595018972	Amidase; Region: Amidase; pfam01425
216595018974	PS00017 ATP/GTP-binding site motif A (P-loop).
216595018975	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595018976	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595018977	LysR substrate binding domain; Region: LysR_substrate; pfam03466
216595018978	dimerization interface [polypeptide binding]; other site
216595018980	PS00044 Bacterial regulatory proteins, lysR family signature.
216595018982	Transcriptional regulators [Transcription]; Region: PurR; COG1609
216595018983	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
216595018984	DNA binding site [nucleotide binding]
216595018985	domain linker motif; other site
216595018986	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
216595018987	dimerization interface [polypeptide binding]; other site
216595018988	ligand binding site [chemical binding]; other site
216595018991	short chain dehydrogenase; Provisional; Region: PRK07060
216595018992	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216595018993	NAD(P) binding site [chemical binding]; other site
216595018994	active site
216595018996	PS00061 Short-chain dehydrogenases/reductases family signature.
216595018997	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
216595018998	uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804
216595018999	N- and C-terminal domain interface [polypeptide binding]; other site
216595019000	putative active site [active]
216595019001	MgATP binding site [chemical binding]; other site
216595019002	catalytic site [active]
216595019003	metal binding site [ion binding]; metal-binding site
216595019004	putative xylulose binding site [chemical binding]; other site
216595019005	putative homodimer interface [polypeptide binding]; other site
216595019007	PS00445 FGGY family of carbohydrate kinases signature 2.
216595019009	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
216595019010	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
216595019011	NAD(P) binding site [chemical binding]; other site
216595019014	PS00059 Zinc-containing alcohol dehydrogenases signature.
216595019015	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
216595019016	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
216595019017	TM-ABC transporter signature motif; other site
216595019019	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
216595019020	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
216595019021	Walker A/P-loop; other site
216595019022	ATP binding site [chemical binding]; other site
216595019023	Q-loop/lid; other site
216595019024	ABC transporter signature motif; other site
216595019025	Walker B; other site
216595019026	D-loop; other site
216595019027	H-loop/switch region; other site
216595019028	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
216595019030	PS00211 ABC transporters family signature.
216595019032	PS00017 ATP/GTP-binding site motif A (P-loop).
216595019033	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
216595019034	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321
216595019035	putative ligand binding site [chemical binding]; other site
216595019037	PS00687 Aldehyde dehydrogenases glutamic acid active site.
216595019038	4 probable transmembrane helices predicted for PFLU3997 by TMHMM2.0 at aa 20-42, 47-69, 111-133 and 137-159
216595019040	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595019041	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
216595019042	Strictosidine synthase; Region: Str_synth; pfam03088
216595019044	Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101
216595019045	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595019046	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
216595019049	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
216595019050	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
216595019051	Walker A/P-loop; other site
216595019052	ATP binding site [chemical binding]; other site
216595019053	Q-loop/lid; other site
216595019054	ABC transporter signature motif; other site
216595019055	Walker B; other site
216595019056	D-loop; other site
216595019057	H-loop/switch region; other site
216595019059	PS00211 ABC transporters family signature.
216595019060	PS00017 ATP/GTP-binding site motif A (P-loop).
216595019061	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
216595019062	catalytic core [active]
216595019063	1 probable transmembrane helix predicted for PFLU4003 by TMHMM2.0 at aa 28-47
216595019065	4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279
216595019066	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
216595019068	11 probable transmembrane helices predicted for PFLU4004 by TMHMM2.0 at aa 7-29, 80-102, 115-132, 163-197, 204-226, 257-279, 291-308, 313-332, 345-367, 377-399 and 406-428
216595019069	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
216595019070	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
216595019072	9 probable transmembrane helices predicted for PFLU4005 by TMHMM2.0 at aa 12-34, 85-107, 128-150, 170-192, 205-227, 265-287, 299-316, 320-342 and 354-373
216595019073	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
216595019074	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
216595019075	Walker A/P-loop; other site
216595019076	ATP binding site [chemical binding]; other site
216595019077	Q-loop/lid; other site
216595019078	ABC transporter signature motif; other site
216595019079	Walker B; other site
216595019080	D-loop; other site
216595019081	H-loop/switch region; other site
216595019083	PS00017 ATP/GTP-binding site motif A (P-loop).
216595019084	low G+C contetn region (47.92%)
216595019085	Condensation domain; Region: Condensation; pfam00668
216595019086	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
216595019087	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
216595019088	acyl-activating enzyme (AAE) consensus motif; other site
216595019089	AMP binding site [chemical binding]; other site
216595019090	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
216595019091	Condensation domain; Region: Condensation; pfam00668
216595019092	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
216595019093	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
216595019094	acyl-activating enzyme (AAE) consensus motif; other site
216595019095	AMP binding site [chemical binding]; other site
216595019096	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
216595019098	PS00012 Phosphopantetheine attachment site.
216595019100	PS00455 Putative AMP-binding domain signature.
216595019103	PS00012 Phosphopantetheine attachment site.
216595019105	PS00455 Putative AMP-binding domain signature.
216595019107	low G+C content region (45.08%)
216595019108	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
216595019109	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216595019110	DNA binding residues [nucleotide binding]
216595019111	dimerization interface [polypeptide binding]; other site
216595019113	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
216595019116	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
216595019117	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
216595019120	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
216595019122	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
216595019123	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
216595019124	Walker A/P-loop; other site
216595019125	ATP binding site [chemical binding]; other site
216595019126	Q-loop/lid; other site
216595019127	ABC transporter signature motif; other site
216595019128	Walker B; other site
216595019129	D-loop; other site
216595019130	H-loop/switch region; other site
216595019132	PS00211 ABC transporters family signature.
216595019133	PS00017 ATP/GTP-binding site motif A (P-loop).
216595019134	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
216595019135	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
216595019136	active site
216595019137	catalytic tetrad [active]
216595019139	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
216595019140	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595019141	substrate binding pocket [chemical binding]; other site
216595019142	membrane-bound complex binding site; other site
216595019143	hinge residues; other site
216595019145	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
216595019146	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
216595019147	Walker A/P-loop; other site
216595019148	ATP binding site [chemical binding]; other site
216595019149	Q-loop/lid; other site
216595019150	ABC transporter signature motif; other site
216595019151	Walker B; other site
216595019152	D-loop; other site
216595019153	H-loop/switch region; other site
216595019155	PS00211 ABC transporters family signature.
216595019156	PS00017 ATP/GTP-binding site motif A (P-loop).
216595019157	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595019158	dimer interface [polypeptide binding]; other site
216595019159	conserved gate region; other site
216595019160	putative PBP binding loops; other site
216595019161	ABC-ATPase subunit interface; other site
216595019163	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595019164	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
216595019165	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595019166	dimer interface [polypeptide binding]; other site
216595019167	conserved gate region; other site
216595019168	putative PBP binding loops; other site
216595019169	ABC-ATPase subunit interface; other site
216595019171	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595019172	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
216595019173	classical (c) SDRs; Region: SDR_c; cd05233
216595019174	NAD(P) binding site [chemical binding]; other site
216595019175	active site
216595019177	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
216595019178	putative active site [active]
216595019180	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
216595019182	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
216595019183	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
216595019185	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111
216595019186	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
216595019187	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
216595019188	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
216595019191	PS00867 Carbamoyl-phosphate synthase subdomain signature 2.
216595019192	PS00866 Carbamoyl-phosphate synthase subdomain signature 1.
216595019194	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
216595019195	carboxyltransferase (CT) interaction site; other site
216595019196	biotinylation site [posttranslational modification]; other site
216595019198	PS00188 Biotin-requiring enzymes attachment site.
216595019199	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
216595019200	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595019201	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
216595019202	putative dimerization interface [polypeptide binding]; other site
216595019205	PS00044 Bacterial regulatory proteins, lysR family signature.
216595019206	aspartate aminotransferase; Provisional; Region: PRK06107
216595019207	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216595019208	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595019209	homodimer interface [polypeptide binding]; other site
216595019210	catalytic residue [active]
216595019212	PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site.
216595019213	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595019214	putative substrate translocation pore; other site
216595019215	14 probable transmembrane helices predicted for PFLU4028 by TMHMM2.0 at aa 13-35, 55-74, 81-100, 110-132, 144-166, 171-193, 206-228, 232-251, 272-291, 306-328, 337-359, 363-385, 405-427 and 469-491
216595019217	outer membrane porin, OprD family; Region: OprD; pfam03573
216595019219	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216595019220	active site
216595019221	motif I; other site
216595019222	motif II; other site
216595019223	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595019225	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595019226	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
216595019227	substrate binding pocket [chemical binding]; other site
216595019228	membrane-bound complex binding site; other site
216595019229	hinge residues; other site
216595019231	PS01039 Bacterial extracellular solute-binding proteins, family 3 signature.
216595019232	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
216595019233	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595019234	dimer interface [polypeptide binding]; other site
216595019235	conserved gate region; other site
216595019236	putative PBP binding loops; other site
216595019237	ABC-ATPase subunit interface; other site
216595019238	5 probable transmembrane helices predicted for PFLU4032 by TMHMM2.0 at aa 27-45, 74-96, 103-125, 135-157 and 240-262
216595019240	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
216595019241	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
216595019242	active site
216595019243	non-prolyl cis peptide bond; other site
216595019244	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
216595019245	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
216595019246	putative DNA binding site [nucleotide binding]; other site
216595019247	putative Zn2+ binding site [ion binding]; other site
216595019248	AsnC family; Region: AsnC_trans_reg; pfam01037
216595019250	Pyruvate-formate lyase [Energy production and conversion]; Region: PflD; COG1882
216595019251	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
216595019252	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
216595019253	inhibitor-cofactor binding pocket; inhibition site
216595019254	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595019255	catalytic residue [active]
216595019257	PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site.
216595019258	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
216595019259	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
216595019260	putative ligand binding site [chemical binding]; other site
216595019261	NAD binding site [chemical binding]; other site
216595019262	dimerization interface [polypeptide binding]; other site
216595019263	catalytic site [active]
216595019265	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
216595019266	tartrate dehydrogenase; Region: TTC; TIGR02089
216595019268	PS00470 Isocitrate and isopropylmalate dehydrogenases signature.
216595019269	succinic semialdehyde dehydrogenase; Region: PLN02278
216595019270	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
216595019271	tetramerization interface [polypeptide binding]; other site
216595019272	NAD(P) binding site [chemical binding]; other site
216595019273	catalytic residues [active]
216595019275	PS00070 Aldehyde dehydrogenases cysteine active site.
216595019276	PS00687 Aldehyde dehydrogenases glutamic acid active site.
216595019277	acetylornithine deacetylase; Provisional; Region: PRK07522
216595019278	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
216595019279	metal binding site [ion binding]; metal-binding site
216595019280	putative dimer interface [polypeptide binding]; other site
216595019283	PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1.
216595019284	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
216595019285	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
216595019286	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
216595019288	1 probable transmembrane helix predicted for PFLU4041 by TMHMM2.0 at aa 7-24
216595019289	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
216595019290	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
216595019291	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
216595019294	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
216595019295	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
216595019296	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
216595019297	Walker A/P-loop; other site
216595019298	ATP binding site [chemical binding]; other site
216595019299	Q-loop/lid; other site
216595019300	ABC transporter signature motif; other site
216595019301	Walker B; other site
216595019302	D-loop; other site
216595019303	H-loop/switch region; other site
216595019304	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
216595019305	Walker A/P-loop; other site
216595019306	ATP binding site [chemical binding]; other site
216595019307	Q-loop/lid; other site
216595019308	ABC transporter signature motif; other site
216595019309	Walker B; other site
216595019310	D-loop; other site
216595019311	H-loop/switch region; other site
216595019312	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
216595019315	PS00211 ABC transporters family signature.
216595019316	PS00017 ATP/GTP-binding site motif A (P-loop).
216595019318	PS00017 ATP/GTP-binding site motif A (P-loop).
216595019319	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
216595019320	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595019321	dimer interface [polypeptide binding]; other site
216595019322	conserved gate region; other site
216595019323	ABC-ATPase subunit interface; other site
216595019325	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
216595019326	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595019327	dimer interface [polypeptide binding]; other site
216595019328	conserved gate region; other site
216595019329	putative PBP binding loops; other site
216595019330	ABC-ATPase subunit interface; other site
216595019332	PS00962 Ribosomal protein S2 signature 1.
216595019333	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
216595019334	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
216595019336	PS00867 Carbamoyl-phosphate synthase subdomain signature 2.
216595019337	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
216595019338	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
216595019340	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
216595019341	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
216595019343	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
216595019344	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216595019345	Coenzyme A binding pocket [chemical binding]; other site
216595019347	Protein of unknown function (DUF861); Region: Cupin_3; pfam05899
216595019349	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595019350	transcriptional activator TtdR; Provisional; Region: PRK09801
216595019351	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
216595019352	putative effector binding pocket; other site
216595019353	putative dimerization interface [polypeptide binding]; other site
216595019356	PS00044 Bacterial regulatory proteins, lysR family signature.
216595019357	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812
216595019358	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
216595019359	dimer interface [polypeptide binding]; other site
216595019360	active site
216595019361	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
216595019362	substrate binding site [chemical binding]; other site
216595019363	catalytic residue [active]
216595019365	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
216595019367	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
216595019368	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216595019369	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
216595019370	Coenzyme A binding pocket [chemical binding]; other site
216595019372	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
216595019373	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
216595019374	NAD binding site [chemical binding]; other site
216595019375	catalytic residues [active]
216595019377	PS00070 Aldehyde dehydrogenases cysteine active site.
216595019378	Protein of unknown function (DUF796); Region: DUF796; pfam05638
216595019380	4 probable transmembrane helices predicted for PFLU4059 by TMHMM2.0 at aa 30-52, 56-78, 90-112 and 116-135
216595019381	PS00237 G-protein coupled receptors signature.
216595019382	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
216595019383	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
216595019384	active site
216595019385	non-prolyl cis peptide bond; other site
216595019386	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
216595019387	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
216595019388	ligand binding site [chemical binding]; other site
216595019390	PS01068 OmpA-like domain.
216595019391	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595019392	Domain of unknown function (DUF4398); Region: DUF4398; pfam14346
216595019393	Cytochrome c; Region: Cytochrom_C; pfam00034
216595019394	PS00017 ATP/GTP-binding site motif A (P-loop).
216595019395	PS00190 Cytochrome c family heme-binding site signature.
216595019396	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_3; cd06151
216595019397	homotrimer interaction site [polypeptide binding]; other site
216595019398	putative active site [active]
216595019400	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
216595019401	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
216595019403	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
216595019404	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595019405	substrate binding pocket [chemical binding]; other site
216595019406	membrane-bound complex binding site; other site
216595019407	hinge residues; other site
216595019409	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
216595019410	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
216595019411	Walker A/P-loop; other site
216595019412	ATP binding site [chemical binding]; other site
216595019413	Q-loop/lid; other site
216595019414	ABC transporter signature motif; other site
216595019415	Walker B; other site
216595019416	D-loop; other site
216595019417	H-loop/switch region; other site
216595019418	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
216595019420	PS00211 ABC transporters family signature.
216595019421	PS00017 ATP/GTP-binding site motif A (P-loop).
216595019422	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595019423	dimer interface [polypeptide binding]; other site
216595019424	conserved gate region; other site
216595019425	putative PBP binding loops; other site
216595019426	ABC-ATPase subunit interface; other site
216595019428	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595019429	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
216595019430	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216595019431	N-terminal plug; other site
216595019432	ligand-binding site [chemical binding]; other site
216595019434	PS00017 ATP/GTP-binding site motif A (P-loop).
216595019436	type II secretion system secreton cluster 3
216595019437	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
216595019438	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
216595019439	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
216595019440	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
216595019441	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
216595019446	Protein of unknown function (DUF2531); Region: DUF2531; pfam10748
216595019447	1 probable transmembrane helix predicted for PFLU4071 by TMHMM2.0 at aa 7-29
216595019448	Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741
216595019449	1 probable transmembrane helix predicted for PFLU4072 by TMHMM2.0 at aa 13-35
216595019450	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
216595019451	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
216595019454	1 probable transmembrane helix predicted for PFLU4074 by TMHMM2.0 at aa 7-29
216595019455	general secretion pathway protein J; Validated; Region: PRK08808
216595019456	1 probable transmembrane helix predicted for PFLU4075 by TMHMM2.0 at aa 13-35
216595019458	PS00409 Prokaryotic N-terminal methylation site.
216595019459	1 probable transmembrane helix predicted for PFLU4076 by TMHMM2.0 at aa 7-29
216595019461	type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708
216595019462	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
216595019464	1 probable transmembrane helix predicted for PFLU4077 by TMHMM2.0 at aa 7-29
216595019465	PS00409 Prokaryotic N-terminal methylation site.
216595019466	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
216595019467	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
216595019468	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
216595019471	1 probable transmembrane helix predicted for PFLU4078 by TMHMM2.0 at aa 13-35
216595019472	PS00409 Prokaryotic N-terminal methylation site.
216595019473	type II secretion system protein F; Region: GspF; TIGR02120
216595019474	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
216595019475	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
216595019478	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
216595019479	type II secretion system protein E; Region: type_II_gspE; TIGR02533
216595019480	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
216595019481	Walker A motif; other site
216595019482	ATP binding site [chemical binding]; other site
216595019483	Walker B motif; other site
216595019485	PS00662 Bacterial type II secretion system protein E signature.
216595019486	PS00017 ATP/GTP-binding site motif A (P-loop).
216595019488	low G+C content region (49.94%)
216595019489	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
216595019490	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
216595019491	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
216595019492	domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758
216595019493	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
216595019497	PS00018 EF-hand calcium-binding domain.
216595019498	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
216595019499	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
216595019501	Transcriptional regulators [Transcription]; Region: PurR; COG1609
216595019502	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
216595019503	DNA binding site [nucleotide binding]
216595019504	domain linker motif; other site
216595019505	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
216595019506	putative ligand binding site [chemical binding]; other site
216595019507	putative dimerization interface [polypeptide binding]; other site
216595019510	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
216595019511	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216595019512	N-terminal plug; other site
216595019513	ligand-binding site [chemical binding]; other site
216595019516	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
216595019517	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
216595019518	active site
216595019519	non-prolyl cis peptide bond; other site
216595019520	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
216595019521	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595019522	substrate binding pocket [chemical binding]; other site
216595019523	membrane-bound complex binding site; other site
216595019525	iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231
216595019526	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
216595019527	Walker A/P-loop; other site
216595019528	ATP binding site [chemical binding]; other site
216595019529	Q-loop/lid; other site
216595019530	ABC transporter signature motif; other site
216595019531	Walker B; other site
216595019532	D-loop; other site
216595019533	H-loop/switch region; other site
216595019535	PS00211 ABC transporters family signature.
216595019536	PS00017 ATP/GTP-binding site motif A (P-loop).
216595019537	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
216595019538	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
216595019539	ABC-ATPase subunit  interface; other site
216595019540	dimer interface [polypeptide binding]; other site
216595019541	putative PBP binding regions; other site
216595019543	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
216595019544	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
216595019545	putative PBP binding regions; other site
216595019546	ABC-ATPase subunit  interface; other site
216595019548	iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411
216595019549	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
216595019550	siderophore binding site; other site
216595019553	Secretin and TonB N terminus short domain; Region: STN; smart00965
216595019554	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
216595019555	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216595019556	N-terminal plug; other site
216595019557	ligand-binding site [chemical binding]; other site
216595019559	PS01156 TonB-dependent receptor proteins signature 2.
216595019562	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
216595019563	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
216595019564	putative DNA binding site [nucleotide binding]; other site
216595019565	putative Zn2+ binding site [ion binding]; other site
216595019566	AsnC family; Region: AsnC_trans_reg; pfam01037
216595019568	PS00519 Bacterial regulatory proteins, asnC family signature.
216595019569	14 probable transmembrane helices predicted for PFLU4095 by TMHMM2.0 at aa 20-39, 49-71, 78-97, 131-153, 158-180, 190-212, 217-236, 246-265, 278-300, 310-330, 351-373, 383-405, 426-448 and 463-485
216595019570	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
216595019571	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
216595019573	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
216595019574	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
216595019575	Walker A/P-loop; other site
216595019576	ATP binding site [chemical binding]; other site
216595019577	Q-loop/lid; other site
216595019578	ABC transporter signature motif; other site
216595019579	Walker B; other site
216595019580	D-loop; other site
216595019581	H-loop/switch region; other site
216595019582	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
216595019584	PS00211 ABC transporters family signature.
216595019585	PS00017 ATP/GTP-binding site motif A (P-loop).
216595019586	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
216595019587	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595019588	dimer interface [polypeptide binding]; other site
216595019589	conserved gate region; other site
216595019590	putative PBP binding loops; other site
216595019591	ABC-ATPase subunit interface; other site
216595019593	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595019594	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
216595019595	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595019596	substrate binding pocket [chemical binding]; other site
216595019597	membrane-bound complex binding site; other site
216595019598	hinge residues; other site
216595019600	Transcriptional regulators [Transcription]; Region: GntR; COG1802
216595019601	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595019602	DNA-binding site [nucleotide binding]; DNA binding site
216595019603	FCD domain; Region: FCD; pfam07729
216595019606	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
216595019607	HAMP domain; Region: HAMP; pfam00672
216595019608	dimerization interface [polypeptide binding]; other site
216595019609	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595019610	dimer interface [polypeptide binding]; other site
216595019611	phosphorylation site [posttranslational modification]
216595019612	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595019613	ATP binding site [chemical binding]; other site
216595019614	Mg2+ binding site [ion binding]; other site
216595019615	G-X-G motif; other site
216595019619	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
216595019620	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595019621	active site
216595019622	phosphorylation site [posttranslational modification]
216595019623	intermolecular recognition site; other site
216595019624	dimerization interface [polypeptide binding]; other site
216595019625	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216595019626	DNA binding site [nucleotide binding]
216595019629	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
216595019630	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
216595019631	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
216595019632	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
216595019633	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
216595019634	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
216595019635	Surface antigen; Region: Bac_surface_Ag; pfam01103
216595019642	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
216595019643	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595019644	Major Facilitator Superfamily; Region: MFS_1; pfam07690
216595019645	putative substrate translocation pore; other site
216595019646	12 probable transmembrane helices predicted for PFLU4106 by TMHMM2.0 at aa 13-35, 50-72, 79-97, 101-123, 135-157, 162-181, 201-223, 238-260, 265-287, 291-313, 326-348 and 353-375
216595019648	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
216595019649	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
216595019651	low G+C content region (49.51%)
216595019652	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
216595019653	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
216595019655	Transcriptional regulator [Transcription]; Region: IclR; COG1414
216595019656	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
216595019657	Bacterial transcriptional regulator; Region: IclR; pfam01614
216595019660	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
216595019661	TrkA-N domain; Region: TrkA_N; pfam02254
216595019662	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
216595019664	PS00283 Soybean trypsin inhibitor (Kunitz) protease inhibitors family signature.
216595019665	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
216595019666	active site
216595019667	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
216595019668	C-terminal domain of type I, class II extradiol dioxygenases; catalytic domain; Region: ED_TypeI_classII_C; cd08343
216595019669	active site
216595019670	metal binding site [ion binding]; metal-binding site
216595019672	NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151
216595019673	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
216595019674	NAD(P) binding site [chemical binding]; other site
216595019675	catalytic residues [active]
216595019677	PS00687 Aldehyde dehydrogenases glutamic acid active site.
216595019678	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
216595019679	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595019682	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
216595019683	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
216595019684	AsnC family; Region: AsnC_trans_reg; pfam01037
216595019686	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
216595019687	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260
216595019688	putative NAD(P) binding site [chemical binding]; other site
216595019689	catalytic Zn binding site [ion binding]; other site
216595019690	structural Zn binding site [ion binding]; other site
216595019692	PS00059 Zinc-containing alcohol dehydrogenases signature.
216595019694	CHASE domain; Region: CHASE; pfam03924
216595019695	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
216595019696	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216595019697	metal binding site [ion binding]; metal-binding site
216595019698	active site
216595019699	I-site; other site
216595019700	2 probable transmembrane helices predicted for PFLU4116 by TMHMM2.0 at aa 24-46 and 318-340
216595019702	VacJ like lipoprotein; Region: VacJ; cl01073
216595019704	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595019705	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
216595019708	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595019709	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
216595019710	Protein export membrane protein; Region: SecD_SecF; cl14618
216595019712	PS00095 C-5 cytosine-specific DNA methylases C-terminal signature.
216595019713	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
216595019714	HlyD family secretion protein; Region: HlyD_3; pfam13437
216595019716	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595019717	signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549
216595019718	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595019719	dimerization interface [polypeptide binding]; other site
216595019720	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595019721	dimer interface [polypeptide binding]; other site
216595019722	phosphorylation site [posttranslational modification]
216595019723	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595019724	ATP binding site [chemical binding]; other site
216595019725	Mg2+ binding site [ion binding]; other site
216595019726	G-X-G motif; other site
216595019727	2 probable transmembrane helices predicted for PFLU4121 by TMHMM2.0 at aa 10-32 and 166-185
216595019731	DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710
216595019732	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595019733	active site
216595019734	phosphorylation site [posttranslational modification]
216595019735	intermolecular recognition site; other site
216595019736	dimerization interface [polypeptide binding]; other site
216595019737	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216595019738	DNA binding site [nucleotide binding]
216595019741	Prophage 4
216595019742	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
216595019743	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595019744	dimerization interface [polypeptide binding]; other site
216595019745	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
216595019746	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595019747	dimer interface [polypeptide binding]; other site
216595019748	putative CheW interface [polypeptide binding]; other site
216595019749	2 probable transmembrane helices predicted for PFLU4125 by TMHMM2.0 at aa 32-54 and 214-236
216595019752	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
216595019753	GAF domain; Region: GAF; pfam01590
216595019755	putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830
216595019756	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216595019757	non-specific DNA binding site [nucleotide binding]; other site
216595019758	salt bridge; other site
216595019759	sequence-specific DNA binding site [nucleotide binding]; other site
216595019760	Superinfection immunity protein; Region: Imm_superinfect; pfam14373
216595019761	Predicted chitinase [General function prediction only]; Region: COG3179
216595019762	catalytic residue [active]
216595019764	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
216595019767	Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076
216595019769	PS00430 TonB-dependent receptor proteins signature 1.
216595019771	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
216595019772	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
216595019773	active site
216595019775	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
216595019776	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
216595019777	DNA binding residues [nucleotide binding]
216595019779	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
216595019780	IHF dimer interface [polypeptide binding]; other site
216595019781	IHF - DNA interface [nucleotide binding]; other site
216595019783	PS00045 Bacterial histone-like DNA-binding proteins signature.
216595019784	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
216595019785	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
216595019786	putative tRNA-binding site [nucleotide binding]; other site
216595019787	B3/4 domain; Region: B3_4; pfam03483
216595019788	tRNA synthetase B5 domain; Region: B5; smart00874
216595019789	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
216595019790	dimer interface [polypeptide binding]; other site
216595019791	motif 1; other site
216595019792	motif 3; other site
216595019793	motif 2; other site
216595019794	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
216595019799	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
216595019800	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
216595019801	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
216595019802	dimer interface [polypeptide binding]; other site
216595019803	motif 1; other site
216595019804	active site
216595019805	motif 2; other site
216595019806	motif 3; other site
216595019808	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
216595019809	PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1.
216595019811	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
216595019812	23S rRNA binding site [nucleotide binding]; other site
216595019813	L21 binding site [polypeptide binding]; other site
216595019814	L13 binding site [polypeptide binding]; other site
216595019816	PS00937 Ribosomal protein L20 signature.
216595019817	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
216595019819	PS00936 Ribosomal protein L35 signature.
216595019820	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
216595019821	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
216595019822	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
216595019825	PS00938 Initiation factor 3 signature.
216595019826	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
216595019827	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
216595019828	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
216595019829	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
216595019830	active site
216595019831	dimer interface [polypeptide binding]; other site
216595019832	motif 1; other site
216595019833	motif 2; other site
216595019834	motif 3; other site
216595019835	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
216595019836	anticodon binding site; other site
216595019838	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
216595019840	PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1.
216595019843	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
216595019844	DNA-binding site [nucleotide binding]; DNA binding site
216595019845	RNA-binding motif; other site
216595019847	PS00352 'Cold-shock' DNA-binding domain signature.
216595019848	Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720
216595019849	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595019850	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
216595019851	active site
216595019852	tetramer interface [polypeptide binding]; other site
216595019854	PS01247 Inosine-uridine preferring nucleoside hydrolase family signature.
216595019855	D-ribose pyranase; Provisional; Region: PRK11797
216595019857	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
216595019858	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
216595019859	substrate binding site [chemical binding]; other site
216595019860	dimer interface [polypeptide binding]; other site
216595019861	ATP binding site [chemical binding]; other site
216595019863	PS00017 ATP/GTP-binding site motif A (P-loop).
216595019864	PS00584 pfkB family of carbohydrate kinases signature 2.
216595019865	PS00583 pfkB family of carbohydrate kinases signature 1.
216595019866	Transcriptional regulators [Transcription]; Region: PurR; COG1609
216595019867	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
216595019868	DNA binding site [nucleotide binding]
216595019869	domain linker motif; other site
216595019870	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
216595019873	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
216595019874	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
216595019875	TM-ABC transporter signature motif; other site
216595019876	PS00307 Legume lectins beta-chain signature.
216595019878	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595019879	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
216595019880	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
216595019881	Walker A/P-loop; other site
216595019882	ATP binding site [chemical binding]; other site
216595019883	Q-loop/lid; other site
216595019884	ABC transporter signature motif; other site
216595019885	Walker B; other site
216595019886	D-loop; other site
216595019887	H-loop/switch region; other site
216595019888	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
216595019890	PS00211 ABC transporters family signature.
216595019892	PS00017 ATP/GTP-binding site motif A (P-loop).
216595019893	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
216595019894	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
216595019895	ligand binding site [chemical binding]; other site
216595019897	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411
216595019898	homodimer interface [polypeptide binding]; other site
216595019899	active site
216595019901	PS00144 Asparaginase / glutaminase active site signature 1.
216595019902	PS00917 Asparaginase / glutaminase active site signature 2.
216595019903	PS00017 ATP/GTP-binding site motif A (P-loop).
216595019904	Protein of unknown function (DUF1654); Region: DUF1654; pfam07867
216595019906	DNA-specific endonuclease I; Provisional; Region: PRK15137
216595019907	Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356
216595019908	1 probable transmembrane helix predicted for PFLU4163 by TMHMM2.0 at aa 13-30
216595019910	PS00017 ATP/GTP-binding site motif A (P-loop).
216595019911	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595019912	carbon storage regulator; Provisional; Region: PRK01712
216595019914	2 probable transmembrane helices predicted for PFLU4166 by TMHMM2.0 at aa 13-35 and 45-62
216595019915	putative phosphatase; Provisional; Region: PRK11587
216595019916	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216595019917	active site
216595019918	motif I; other site
216595019919	motif II; other site
216595019921	PS01228 Hypothetical cof family signature 1.
216595019922	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
216595019923	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
216595019924	1 probable transmembrane helix predicted for PFLU4169 by TMHMM2.0 at aa 20-42
216595019925	Protein of unknown function (DUF2790); Region: DUF2790; pfam10976
216595019926	1 probable transmembrane helix predicted for PFLU4170 by TMHMM2.0 at aa 30-52
216595019927	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
216595019928	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595019929	active site
216595019930	phosphorylation site [posttranslational modification]
216595019931	intermolecular recognition site; other site
216595019932	dimerization interface [polypeptide binding]; other site
216595019933	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216595019934	DNA binding site [nucleotide binding]
216595019937	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
216595019938	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595019939	dimerization interface [polypeptide binding]; other site
216595019940	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595019941	dimer interface [polypeptide binding]; other site
216595019942	phosphorylation site [posttranslational modification]
216595019943	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595019944	ATP binding site [chemical binding]; other site
216595019945	G-X-G motif; other site
216595019946	2 probable transmembrane helices predicted for PFLU4172 by TMHMM2.0 at aa 10-32 and 169-191
216595019950	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
216595019951	putative substrate binding pocket [chemical binding]; other site
216595019952	AC domain interface; other site
216595019953	catalytic triad [active]
216595019954	AB domain interface; other site
216595019955	interchain disulfide; other site
216595019957	PS01334 Pyrrolidone-carboxylate peptidase cysteine active site.
216595019958	PS01333 Pyrrolidone-carboxylate peptidase glutamic acid active site.
216595019959	Predicted membrane protein [Function unknown]; Region: COG3817
216595019960	Protein of unknown function (DUF979); Region: DUF979; pfam06166
216595019962	Predicted membrane protein [Function unknown]; Region: COG3819
216595019964	Domain of unknown function (DUF4410); Region: DUF4410; pfam14366
216595019965	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595019966	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595019967	putative substrate translocation pore; other site
216595019968	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595019969	14 probable transmembrane helices predicted for PFLU4178 by TMHMM2.0 at aa 20-42, 57-79, 86-108, 112-134, 147-169, 173-195, 208-230, 235-254, 282-304, 309-328, 341-363, 368-390, 403-425 and 440-462
216595019971	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595019972	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
216595019973	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
216595019974	PS00043 Bacterial regulatory proteins, gntR family signature.
216595019976	oxidoreductase; Validated; Region: PRK05717
216595019977	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216595019978	NAD(P) binding site [chemical binding]; other site
216595019979	active site
216595019981	PS00061 Short-chain dehydrogenases/reductases family signature.
216595019982	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
216595019983	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
216595019984	homodimer interface [polypeptide binding]; other site
216595019985	substrate-cofactor binding pocket; other site
216595019986	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595019987	catalytic residue [active]
216595019989	PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site.
216595019990	amidophosphoribosyltransferase; Provisional; Region: PRK09246
216595019991	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
216595019992	active site
216595019993	tetramer interface [polypeptide binding]; other site
216595019994	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
216595019995	active site
216595019996	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
216595019998	PS00103 Purine/pyrimidine phosphoribosyl transferases signature.
216595020000	PS00443 Glutamine amidotransferases class-II active site.
216595020001	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
216595020002	Colicin V production protein; Region: Colicin_V; cl00567
216595020004	PS00294 Prenyl group binding site (CAAX box).
216595020005	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
216595020006	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
216595020007	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
216595020009	PS01011 Folylpolyglutamate synthase signature 1.
216595020010	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
216595020011	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
216595020013	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
216595020014	active site
216595020016	gcgggnnnncccgc
216595020017	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
216595020018	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
216595020019	dimerization interface 3.5A [polypeptide binding]; other site
216595020020	active site
216595020023	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
216595020024	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
216595020025	PS01070 DNA/RNA non-specific endonucleases active site.
216595020027	PS00211 ABC transporters family signature.
216595020028	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK05671
216595020029	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
216595020032	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
216595020033	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
216595020035	PS01103 Aspartate-semialdehyde dehydrogenase signature.
216595020037	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
216595020038	tartrate dehydrogenase; Region: TTC; TIGR02089
216595020040	PS00470 Isocitrate and isopropylmalate dehydrogenases signature.
216595020041	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595020042	S-adenosylmethionine binding site [chemical binding]; other site
216595020044	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
216595020045	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
216595020046	substrate binding site [chemical binding]; other site
216595020048	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
216595020049	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
216595020050	substrate binding site [chemical binding]; other site
216595020051	ligand binding site [chemical binding]; other site
216595020053	PS01244 Aconitase family signature 2.
216595020054	PS00450 Aconitase family signature 1.
216595020055	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595020056	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595020057	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
216595020058	dimerization interface [polypeptide binding]; other site
216595020060	PS00044 Bacterial regulatory proteins, lysR family signature.
216595020062	PAS fold; Region: PAS_3; pfam08447
216595020063	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595020064	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
216595020065	putative active site [active]
216595020066	heme pocket [chemical binding]; other site
216595020067	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
216595020068	PAS domain S-box; Region: sensory_box; TIGR00229
216595020069	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595020070	putative active site [active]
216595020071	heme pocket [chemical binding]; other site
216595020072	PAS domain S-box; Region: sensory_box; TIGR00229
216595020073	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595020074	putative active site [active]
216595020075	heme pocket [chemical binding]; other site
216595020076	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
216595020077	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216595020078	metal binding site [ion binding]; metal-binding site
216595020079	active site
216595020080	I-site; other site
216595020081	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
216595020089	large tegument protein UL36; Provisional; Region: PHA03247
216595020090	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
216595020091	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
216595020092	FMN binding site [chemical binding]; other site
216595020093	active site
216595020094	catalytic residues [active]
216595020095	substrate binding site [chemical binding]; other site
216595020097	PS01136 Uncharacterized protein family UPF0034 signature.
216595020098	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
216595020099	active site
216595020101	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
216595020102	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
216595020103	Serine hydrolase; Region: Ser_hydrolase; cl17834
216595020104	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
216595020105	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216595020107	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
216595020108	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
216595020109	active site
216595020110	HIGH motif; other site
216595020111	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
216595020112	active site
216595020113	KMSKS motif; other site
216595020115	PS00178 Aminoacyl-transfer RNA synthetases class-I signature.
216595020116	excinuclease ABC subunit B; Provisional; Region: PRK05298
216595020117	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
216595020118	ATP binding site [chemical binding]; other site
216595020119	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
216595020120	nucleotide binding region [chemical binding]; other site
216595020121	ATP-binding site [chemical binding]; other site
216595020122	Ultra-violet resistance protein B; Region: UvrB; pfam12344
216595020123	UvrB/uvrC motif; Region: UVR; pfam02151
216595020127	PS00017 ATP/GTP-binding site motif A (P-loop).
216595020128	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
216595020129	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216595020130	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595020131	homodimer interface [polypeptide binding]; other site
216595020132	catalytic residue [active]
216595020134	PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site.
216595020135	1 probable transmembrane helix predicted for PFLU4210 by TMHMM2.0 at aa 39-61
216595020136	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595020137	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595020138	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
216595020139	putative dimerization interface [polypeptide binding]; other site
216595020142	PS00044 Bacterial regulatory proteins, lysR family signature.
216595020143	putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968
216595020144	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
216595020145	NAD(P) binding site [chemical binding]; other site
216595020146	catalytic residues [active]
216595020148	PS00070 Aldehyde dehydrogenases cysteine active site.
216595020149	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595020150	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595020151	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475
216595020152	putative effector binding pocket; other site
216595020153	putative dimerization interface [polypeptide binding]; other site
216595020156	PS00044 Bacterial regulatory proteins, lysR family signature.
216595020157	putative transporter; Provisional; Region: PRK10054
216595020158	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595020159	putative substrate translocation pore; other site
216595020160	11 probable transmembrane helices predicted for PFLU4214 by TMHMM2.0 at aa 7-29, 44-66, 73-95, 99-116, 146-168, 214-236, 248-270, 280-299, 306-328, 341-363 and 370-392
216595020162	OsmC-like protein; Region: OsmC; cl00767
216595020163	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
216595020164	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
216595020165	active site
216595020166	Zn binding site [ion binding]; other site
216595020169	PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.
216595020170	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
216595020171	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
216595020172	active site
216595020173	substrate binding site [chemical binding]; other site
216595020174	Mg2+ binding site [ion binding]; other site
216595020176	PS00017 ATP/GTP-binding site motif A (P-loop).
216595020177	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
216595020178	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
216595020179	putative ligand binding residues [chemical binding]; other site
216595020181	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
216595020182	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
216595020183	ABC-ATPase subunit  interface; other site
216595020184	dimer interface [polypeptide binding]; other site
216595020185	putative PBP binding regions; other site
216595020186	8 probable transmembrane helices predicted for PFLU4220 by TMHMM2.0 at aa 5-27, 57-79, 92-111, 115-137, 149-168, 190-212, 244-266 and 307-329
216595020188	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
216595020189	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
216595020190	Walker A/P-loop; other site
216595020191	ATP binding site [chemical binding]; other site
216595020192	Q-loop/lid; other site
216595020193	ABC transporter signature motif; other site
216595020194	Walker B; other site
216595020195	D-loop; other site
216595020196	H-loop/switch region; other site
216595020198	PS00017 ATP/GTP-binding site motif A (P-loop).
216595020199	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
216595020200	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216595020201	Coenzyme A binding pocket [chemical binding]; other site
216595020203	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
216595020204	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
216595020206	TspO/MBR family; Region: TspO_MBR; pfam03073
216595020208	4 probable transmembrane helices predicted for PFLU4229 by TMHMM2.0 at aa 45-67, 93-115, 119-140 and 153-175
216595020210	Predicted transporter component [General function prediction only]; Region: COG2391
216595020211	Sulphur transport; Region: Sulf_transp; pfam04143
216595020212	4 probable transmembrane helices predicted for PFLU4230 by TMHMM2.0 at aa 7-26, 41-63, 84-106 and 111-130
216595020214	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268
216595020215	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
216595020216	putative NAD(P) binding site [chemical binding]; other site
216595020219	low G+C content region (47.05%)
216595020220	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
216595020221	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595020222	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
216595020223	dimerization interface [polypeptide binding]; other site
216595020224	substrate binding pocket [chemical binding]; other site
216595020227	PS00044 Bacterial regulatory proteins, lysR family signature.
216595020228	low G+C content region (42.13%)
216595020229	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595020230	putative substrate translocation pore; other site
216595020231	14 probable transmembrane helices predicted for PFLU4234 by TMHMM2.0 at aa 7-29, 44-65, 72-94, 98-120, 133-155, 160-182, 195-214, 219-241, 261-283, 293-312, 325-347, 352-369, 397-419 and 469-491
216595020233	PS00216 Sugar transport proteins signature 1.
216595020234	phosphoglycolate phosphatase; Provisional; Region: PRK13222
216595020235	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216595020236	motif II; other site
216595020238	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
216595020239	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595020240	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
216595020241	PS00041 Bacterial regulatory proteins, araC family signature.
216595020244	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216595020245	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
216595020246	NAD(P) binding site [chemical binding]; other site
216595020247	active site
216595020249	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
216595020250	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
216595020252	Uncharacterized conserved protein [Function unknown]; Region: COG3268
216595020254	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
216595020255	dimer interface [polypeptide binding]; other site
216595020256	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
216595020257	ligand binding site [chemical binding]; other site
216595020258	FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196
216595020259	PS00017 ATP/GTP-binding site motif A (P-loop).
216595020260	Uncharacterized conserved protein [Function unknown]; Region: COG1479
216595020261	Protein of unknown function DUF262; Region: DUF262; pfam03235
216595020262	Uncharacterized conserved protein [Function unknown]; Region: COG3472
216595020264	PS00146 Beta-lactamase class-A active site.
216595020265	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
216595020267	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595020268	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595020269	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
216595020270	dimerization interface [polypeptide binding]; other site
216595020272	PS00044 Bacterial regulatory proteins, lysR family signature.
216595020274	Domain of unknown function (DUF1963); Region: DUF1963; pfam09234
216595020276	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144
216595020277	conserved cys residue [active]
216595020278	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
216595020279	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
216595020280	putative C-terminal domain interface [polypeptide binding]; other site
216595020281	putative GSH binding site (G-site) [chemical binding]; other site
216595020282	putative dimer interface [polypeptide binding]; other site
216595020283	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
216595020284	putative N-terminal domain interface [polypeptide binding]; other site
216595020285	putative dimer interface [polypeptide binding]; other site
216595020286	putative substrate binding pocket (H-site) [chemical binding]; other site
216595020289	PS00017 ATP/GTP-binding site motif A (P-loop).
216595020290	OPT oligopeptide transporter protein; Region: OPT; pfam03169
216595020292	Transposase IS200 like; Region: Y1_Tnp; pfam01797
216595020294	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
216595020295	1 probable transmembrane helix predicted for PFLU4256 by TMHMM2.0 at aa 17-39
216595020296	PS00017 ATP/GTP-binding site motif A (P-loop).
216595020297	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595020298	dimer interface [polypeptide binding]; other site
216595020299	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
216595020300	putative CheW interface [polypeptide binding]; other site
216595020303	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
216595020304	Family of unknown function (DUF633); Region: DUF633; pfam04816
216595020306	Transcriptional regulators [Transcription]; Region: FadR; COG2186
216595020307	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595020308	DNA-binding site [nucleotide binding]; DNA binding site
216595020309	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
216595020312	low G+C content region (40.15%)
216595020313	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595020314	D-galactonate transporter; Region: 2A0114; TIGR00893
216595020315	putative substrate translocation pore; other site
216595020316	12 probable transmembrane helices predicted for PFLU4260 by TMHMM2.0 at aa 27-49, 59-81, 93-112, 118-140, 153-175, 185-207, 255-277, 292-314, 321-340, 344-366, 373-395 and 410-429
216595020318	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
216595020319	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
216595020320	active site
216595020321	tetramer interface [polypeptide binding]; other site
216595020324	PS00294 Prenyl group binding site (CAAX box).
216595020325	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
216595020326	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595020327	substrate binding pocket [chemical binding]; other site
216595020328	membrane-bound complex binding site; other site
216595020329	hinge residues; other site
216595020331	low G+C content region (44.97%)
216595020332	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
216595020333	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
216595020334	active site
216595020336	acetylornithine deacetylase; Provisional; Region: PRK07522
216595020337	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
216595020338	metal binding site [ion binding]; metal-binding site
216595020339	putative dimer interface [polypeptide binding]; other site
216595020342	PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2.
216595020343	Uncharacterized conserved protein [Function unknown]; Region: COG3342
216595020344	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
216595020346	hypothetical protein; Provisional; Region: PRK07490
216595020347	intersubunit interface [polypeptide binding]; other site
216595020348	active site
216595020349	Zn2+ binding site [ion binding]; other site
216595020351	PS00017 ATP/GTP-binding site motif A (P-loop).
216595020352	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595020353	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
216595020354	substrate binding pocket [chemical binding]; other site
216595020355	membrane-bound complex binding site; other site
216595020356	hinge residues; other site
216595020358	PS01039 Bacterial extracellular solute-binding proteins, family 3 signature.
216595020359	1 probable transmembrane helix predicted for PFLU4268 by TMHMM2.0 at aa 7-29
216595020360	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
216595020362	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
216595020363	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595020364	dimer interface [polypeptide binding]; other site
216595020365	conserved gate region; other site
216595020366	putative PBP binding loops; other site
216595020367	ABC-ATPase subunit interface; other site
216595020368	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
216595020369	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
216595020370	Walker A/P-loop; other site
216595020371	ATP binding site [chemical binding]; other site
216595020372	Q-loop/lid; other site
216595020373	ABC transporter signature motif; other site
216595020374	Walker B; other site
216595020375	D-loop; other site
216595020376	H-loop/switch region; other site
216595020378	PS00211 ABC transporters family signature.
216595020379	PS00017 ATP/GTP-binding site motif A (P-loop).
216595020381	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595020382	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595020383	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
216595020384	putative substrate binding pocket [chemical binding]; other site
216595020385	dimerization interface [polypeptide binding]; other site
216595020388	PS00044 Bacterial regulatory proteins, lysR family signature.
216595020389	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
216595020390	homotrimer interaction site [polypeptide binding]; other site
216595020391	putative active site [active]
216595020393	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
216595020394	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
216595020395	NAD(P) binding site [chemical binding]; other site
216595020398	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
216595020399	Dehydroquinase class II; Region: DHquinase_II; pfam01220
216595020400	trimer interface [polypeptide binding]; other site
216595020401	active site
216595020402	dimer interface [polypeptide binding]; other site
216595020404	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
216595020405	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
216595020406	FIST N domain; Region: FIST; smart00897
216595020407	FIST C domain; Region: FIST_C; pfam10442
216595020408	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595020409	dimer interface [polypeptide binding]; other site
216595020410	putative CheW interface [polypeptide binding]; other site
216595020411	PS00017 ATP/GTP-binding site motif A (P-loop).
216595020413	methionine sulfoxide reductase A; Provisional; Region: PRK14054
216595020415	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
216595020416	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
216595020417	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
216595020418	low G+C content region (47.02%)
216595020419	Sulphur transport; Region: Sulf_transp; pfam04143
216595020422	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595020423	H+ Antiporter protein; Region: 2A0121; TIGR00900
216595020424	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595020425	putative substrate translocation pore; other site
216595020426	10 probable transmembrane helices predicted for PFLU4281 by TMHMM2.0 at aa 13-35, 50-72, 84-106, 172-194, 227-249, 259-281, 288-307, 312-334, 347-369 and 373-395
216595020428	DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864
216595020429	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
216595020430	active site
216595020431	substrate binding site [chemical binding]; other site
216595020432	Mg2+ binding site [ion binding]; other site
216595020434	PS01070 DNA/RNA non-specific endonucleases active site.
216595020435	progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948
216595020436	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
216595020437	NAD(P) binding site [chemical binding]; other site
216595020438	active site
216595020440	PS00904 Protein prenyltransferases alpha subunit repeat signature.
216595020441	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
216595020442	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595020443	dimer interface [polypeptide binding]; other site
216595020444	phosphorylation site [posttranslational modification]
216595020445	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595020446	ATP binding site [chemical binding]; other site
216595020447	Mg2+ binding site [ion binding]; other site
216595020448	G-X-G motif; other site
216595020450	PS00017 ATP/GTP-binding site motif A (P-loop).
216595020452	circadian clock protein KaiC; Reviewed; Region: PRK09302
216595020453	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
216595020454	Walker A motif; other site
216595020455	ATP binding site [chemical binding]; other site
216595020456	Walker B motif; other site
216595020457	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
216595020458	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
216595020459	Walker A motif; other site
216595020460	Walker A motif; other site
216595020461	ATP binding site [chemical binding]; other site
216595020462	Walker B motif; other site
216595020464	PS00017 ATP/GTP-binding site motif A (P-loop).
216595020465	PS00017 ATP/GTP-binding site motif A (P-loop).
216595020466	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
216595020467	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595020468	putative substrate translocation pore; other site
216595020470	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
216595020471	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216595020473	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595020474	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595020475	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
216595020476	dimerization interface [polypeptide binding]; other site
216595020479	PS00044 Bacterial regulatory proteins, lysR family signature.
216595020480	hypothetical protein; Validated; Region: PRK06201
216595020481	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
216595020483	aspartate aminotransferase; Provisional; Region: PRK05764
216595020484	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216595020485	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595020486	homodimer interface [polypeptide binding]; other site
216595020487	catalytic residue [active]
216595020489	PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site.
216595020490	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
216595020491	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
216595020492	8 probable transmembrane helices predicted for PFLU4294 by TMHMM2.0 at aa 7-29, 49-71, 84-106, 150-172, 192-214, 229-251, 306-328 and 358-380
216595020494	PS00713 Sodium:dicarboxylate symporter family signature 1.
216595020495	PS00017 ATP/GTP-binding site motif A (P-loop).
216595020496	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
216595020497	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
216595020498	putative dimer interface [polypeptide binding]; other site
216595020501	Domain of unknown function (DUF4279); Region: DUF4279; pfam14106
216595020505	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595020506	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595020507	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
216595020508	putative dimerization interface [polypeptide binding]; other site
216595020511	PS00044 Bacterial regulatory proteins, lysR family signature.
216595020512	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
216595020513	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
216595020514	active site
216595020515	substrate binding site [chemical binding]; other site
216595020516	FMN binding site [chemical binding]; other site
216595020517	putative catalytic residues [active]
216595020519	PS00557 FMN-dependent alpha-hydroxy acid dehydrogenases active site.
216595020520	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
216595020521	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216595020522	metal binding site [ion binding]; metal-binding site
216595020523	active site
216595020524	I-site; other site
216595020526	Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424
216595020528	PAS fold; Region: PAS; pfam00989
216595020529	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595020530	putative active site [active]
216595020531	heme pocket [chemical binding]; other site
216595020532	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
216595020533	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216595020534	metal binding site [ion binding]; metal-binding site
216595020535	active site
216595020536	I-site; other site
216595020537	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
216595020541	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
216595020542	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
216595020543	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216595020544	Walker A/P-loop; other site
216595020545	ATP binding site [chemical binding]; other site
216595020546	Q-loop/lid; other site
216595020547	ABC transporter signature motif; other site
216595020548	Walker B; other site
216595020549	D-loop; other site
216595020550	H-loop/switch region; other site
216595020552	PS00211 ABC transporters family signature.
216595020553	PS00017 ATP/GTP-binding site motif A (P-loop).
216595020555	Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
216595020556	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
216595020557	catalytic residues [active]
216595020558	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
216595020559	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
216595020560	active site residue [active]
216595020562	BolA-like protein; Region: BolA; pfam01722
216595020564	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243
216595020565	fumarate hydratase; Provisional; Region: PRK12425
216595020566	Class II fumarases; Region: Fumarase_classII; cd01362
216595020567	active site
216595020568	tetramer interface [polypeptide binding]; other site
216595020570	PS00017 ATP/GTP-binding site motif A (P-loop).
216595020571	PS00163 Fumarate lyases signature.
216595020572	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
216595020573	EamA-like transporter family; Region: EamA; pfam00892
216595020576	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
216595020577	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
216595020578	dimer interface [polypeptide binding]; other site
216595020579	active site
216595020581	PS00737 Thiolases signature 2.
216595020583	PS00098 Thiolases acyl-enzyme intermediate signature.
216595020584	polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708
216595020585	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
216595020586	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
216595020589	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
216595020590	Uncharacterized conserved protein [Function unknown]; Region: COG4121
216595020591	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
216595020594	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
216595020595	Leucine rich repeat; Region: LRR_8; pfam13855
216595020596	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
216595020598	asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104
216595020599	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
216595020600	active site
216595020601	dimer interface [polypeptide binding]; other site
216595020602	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
216595020603	Ligand Binding Site [chemical binding]; other site
216595020604	Molecular Tunnel; other site
216595020607	GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT
216595020608	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216595020609	Coenzyme A binding pocket [chemical binding]; other site
216595020610	ATP-grasp domain; Region: ATP-grasp_4; cl17255
216595020613	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
216595020614	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
216595020615	putative oligomer interface [polypeptide binding]; other site
216595020616	putative active site [active]
216595020617	metal binding site [ion binding]; metal-binding site
216595020619	PS00290 Immunoglobulins and major histocompatibility complex proteins signature.
216595020620	hypothetical protein; Provisional; Region: PRK00304
216595020622	Global regulator protein family; Region: CsrA; pfam02599
216595020624	short chain dehydrogenase; Provisional; Region: PRK05650
216595020625	classical (c) SDRs; Region: SDR_c; cd05233
216595020626	NAD(P) binding site [chemical binding]; other site
216595020627	active site
216595020629	Protein of unknown function (DUF3309); Region: DUF3309; pfam11752
216595020630	2 probable transmembrane helices predicted for PFLU4326 by TMHMM2.0 at aa 2-21 and 26-48
216595020631	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
216595020632	Sulfatase; Region: Sulfatase; pfam00884
216595020634	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
216595020635	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
216595020636	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
216595020640	long-chain-acyl-CoA synthetase; Validated; Region: PRK08279
216595020641	Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940
216595020642	acyl-activating enzyme (AAE) consensus motif; other site
216595020643	putative AMP binding site [chemical binding]; other site
216595020644	putative active site [active]
216595020645	putative CoA binding site [chemical binding]; other site
216595020647	PS00455 Putative AMP-binding domain signature.
216595020648	Protein of unknown function (DUF3509); Region: DUF3509; pfam12021
216595020649	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
216595020650	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216595020651	DNA binding residues [nucleotide binding]
216595020652	dimerization interface [polypeptide binding]; other site
216595020654	ARD/ARD' family; Region: ARD; pfam03079
216595020656	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595020657	putative substrate translocation pore; other site
216595020658	PS00044 Bacterial regulatory proteins, lysR family signature.
216595020660	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
216595020661	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
216595020662	Tetramer interface [polypeptide binding]; other site
216595020663	active site
216595020664	FMN-binding site [chemical binding]; other site
216595020666	PS00789 Chorismate synthase signature 3.
216595020667	PS00788 Chorismate synthase signature 2.
216595020668	PS00787 Chorismate synthase signature 1.
216595020669	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
216595020670	PS00120 Lipases, serine active site.
216595020671	1 probable transmembrane helix predicted for PFLU4340 by TMHMM2.0 at aa 272-294
216595020672	HemK family putative methylases; Region: hemK_fam; TIGR00536
216595020673	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595020674	S-adenosylmethionine binding site [chemical binding]; other site
216595020676	PS00092 N-6 Adenine-specific DNA methylases signature.
216595020677	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595020678	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
216595020679	Isochorismatase family; Region: Isochorismatase; pfam00857
216595020680	catalytic triad [active]
216595020681	conserved cis-peptide bond; other site
216595020683	2 probable transmembrane helices predicted for PFLU4343 by TMHMM2.0 at aa 20-42 and 62-81
216595020684	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
216595020685	Smr domain; Region: Smr; pfam01713
216595020687	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
216595020688	homodecamer interface [polypeptide binding]; other site
216595020689	GTP cyclohydrolase I; Provisional; Region: PLN03044
216595020690	active site
216595020691	putative catalytic site residues [active]
216595020692	zinc binding site [ion binding]; other site
216595020693	GTP-CH-I/GFRP interaction surface; other site
216595020695	PS00859 GTP cyclohydrolase I signature 1.
216595020696	PS00860 GTP cyclohydrolase I signature 2.
216595020697	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
216595020698	Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417
216595020700	PS00195 Glutaredoxin active site.
216595020701	Helix-turn-helix domain; Region: HTH_28; pfam13518
216595020702	Winged helix-turn helix; Region: HTH_29; pfam13551
216595020703	Homeodomain-like domain; Region: HTH_32; pfam13565
216595020704	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
216595020705	Integrase core domain; Region: rve; pfam00665
216595020706	Integrase core domain; Region: rve_3; pfam13683
216595020708	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
216595020710	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
216595020711	Citrate transporter; Region: CitMHS; pfam03600
216595020713	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595020714	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595020715	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
216595020716	putative dimerization interface [polypeptide binding]; other site
216595020718	PS00044 Bacterial regulatory proteins, lysR family signature.
216595020720	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
216595020721	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
216595020722	putative C-terminal domain interface [polypeptide binding]; other site
216595020723	putative GSH binding site (G-site) [chemical binding]; other site
216595020724	putative dimer interface [polypeptide binding]; other site
216595020725	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
216595020726	N-terminal domain interface [polypeptide binding]; other site
216595020727	dimer interface [polypeptide binding]; other site
216595020728	substrate binding pocket (H-site) [chemical binding]; other site
216595020731	aspartate aminotransferase; Provisional; Region: PRK05764
216595020732	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216595020733	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595020734	homodimer interface [polypeptide binding]; other site
216595020735	catalytic residue [active]
216595020737	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
216595020738	MarR family; Region: MarR_2; pfam12802
216595020740	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
216595020742	11 probable transmembrane helices predicted for PFLU4355 by TMHMM2.0 at aa 38-60, 70-92, 113-135, 150-172, 184-206, 210-232, 253-272, 330-352, 359-381, 396-418 and 430-447
216595020743	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
216595020744	5 probable transmembrane helices predicted for PFLU4356 by TMHMM2.0 at aa 15-37, 49-71, 81-98, 125-147 and 162-184
216595020746	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
216595020747	active site
216595020748	homotetramer interface [polypeptide binding]; other site
216595020750	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
216595020751	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
216595020752	active site
216595020753	catalytic site [active]
216595020754	tetramer interface [polypeptide binding]; other site
216595020756	OHCU decarboxylase; Region: UHCUDC; TIGR03164
216595020757	allantoicase; Provisional; Region: PRK13257
216595020758	Allantoicase repeat; Region: Allantoicase; pfam03561
216595020759	Allantoicase repeat; Region: Allantoicase; pfam03561
216595020762	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
216595020763	ureidoglycolate hydrolase; Provisional; Region: PRK03606
216595020765	Predicted membrane protein [Function unknown]; Region: COG3748
216595020766	Protein of unknown function (DUF989); Region: DUF989; pfam06181
216595020767	Cytochrome c; Region: Cytochrom_C; pfam00034
216595020769	8 probable transmembrane helices predicted for PFLU4363 by TMHMM2.0 at aa 15-34, 81-103, 118-137, 146-163, 173-192, 223-240, 250-267 and 276-295
216595020770	PS00190 Cytochrome c family heme-binding site signature.
216595020771	xanthine permease; Region: pbuX; TIGR03173
216595020773	11 probable transmembrane helices predicted for PFLU4364 by TMHMM2.0 at aa 23-45, 57-79, 108-130, 137-159, 169-191, 198-220, 249-271, 325-347, 351-373, 385-404 and 414-436
216595020774	PS01116 Xanthine/uracil permeases family signature.
216595020775	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114
216595020776	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
216595020777	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
216595020778	active site
216595020779	nucleophile elbow; other site
216595020781	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
216595020782	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
216595020783	putative acyl-acceptor binding pocket; other site
216595020785	1 probable transmembrane helix predicted for PFLU4368 by TMHMM2.0 at aa 22-44
216595020786	septum formation inhibitor; Reviewed; Region: minC; PRK00339
216595020787	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
216595020788	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
216595020791	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
216595020792	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
216595020793	Switch I; other site
216595020794	Switch II; other site
216595020796	PS00017 ATP/GTP-binding site motif A (P-loop).
216595020797	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
216595020799	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
216595020800	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
216595020801	active site
216595020803	PS01129 Rlu family of pseudouridine synthase signature.
216595020804	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
216595020805	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
216595020806	active site
216595020807	metal binding site [ion binding]; metal-binding site
216595020809	2 probable transmembrane helices predicted for PFLU4374 by TMHMM2.0 at aa 5-27 and 32-54
216595020810	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
216595020811	Mechanosensitive ion channel; Region: MS_channel; pfam00924
216595020812	12 probable transmembrane helices predicted for PFLU4375 by TMHMM2.0 at aa 5-27, 139-161, 186-208, 218-240, 261-283, 288-310, 335-357, 367-389, 414-436, 456-478, 499-521 and 531-553
216595020814	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667
216595020815	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
216595020816	metal binding site [ion binding]; metal-binding site
216595020817	putative dimer interface [polypeptide binding]; other site
216595020820	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251
216595020822	PS00017 ATP/GTP-binding site motif A (P-loop).
216595020823	diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938
216595020824	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
216595020825	inhibitor-cofactor binding pocket; inhibition site
216595020826	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595020827	catalytic residue [active]
216595020829	PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site.
216595020831	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
216595020832	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
216595020833	amidase catalytic site [active]
216595020834	Zn binding residues [ion binding]; other site
216595020835	substrate binding site [chemical binding]; other site
216595020837	sensor protein QseC; Provisional; Region: PRK10337
216595020838	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595020839	dimer interface [polypeptide binding]; other site
216595020840	phosphorylation site [posttranslational modification]
216595020841	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595020842	ATP binding site [chemical binding]; other site
216595020843	G-X-G motif; other site
216595020847	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595020848	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
216595020849	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595020850	active site
216595020851	phosphorylation site [posttranslational modification]
216595020852	intermolecular recognition site; other site
216595020853	dimerization interface [polypeptide binding]; other site
216595020854	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216595020855	DNA binding site [nucleotide binding]
216595020858	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
216595020859	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
216595020860	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
216595020861	DsbD alpha interface [polypeptide binding]; other site
216595020862	catalytic residues [active]
216595020864	8 probable transmembrane helices predicted for PFLU4382 by TMHMM2.0 at aa 169-191, 203-225, 235-257, 277-299, 319-341, 354-376, 380-399 and 408-430
216595020866	PS00194 Thioredoxin family active site.
216595020867	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
216595020868	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
216595020869	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
216595020870	catalytic residues [active]
216595020871	4 probable transmembrane helices predicted for PFLU4383 by TMHMM2.0 at aa 10-32, 45-67, 82-101 and 108-130
216595020873	PS00194 Thioredoxin family active site.
216595020874	disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657
216595020875	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
216595020876	dimerization domain [polypeptide binding]; other site
216595020877	dimer interface [polypeptide binding]; other site
216595020878	catalytic residues [active]
216595020879	peptide synthase; Validated; Region: PRK05691
216595020880	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
216595020881	acyl-activating enzyme (AAE) consensus motif; other site
216595020882	active site
216595020883	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
216595020884	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
216595020885	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
216595020886	acyl-activating enzyme (AAE) consensus motif; other site
216595020887	AMP binding site [chemical binding]; other site
216595020888	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
216595020889	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
216595020890	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
216595020891	acyl-activating enzyme (AAE) consensus motif; other site
216595020892	AMP binding site [chemical binding]; other site
216595020893	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
216595020894	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
216595020895	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
216595020896	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
216595020897	acyl-activating enzyme (AAE) consensus motif; other site
216595020898	AMP binding site [chemical binding]; other site
216595020899	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
216595020900	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
216595020902	extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037
216595020903	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
216595020904	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
216595020905	DNA binding residues [nucleotide binding]
216595020908	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
216595020909	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595020910	substrate binding pocket [chemical binding]; other site
216595020911	membrane-bound complex binding site; other site
216595020912	hinge residues; other site
216595020913	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
216595020914	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216595020916	PS01081 Bacterial regulatory proteins, tetR family signature.
216595020917	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
216595020919	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
216595020920	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
216595020921	NAD(P) binding site [chemical binding]; other site
216595020922	substrate binding site [chemical binding]; other site
216595020923	homotetramer interface [polypeptide binding]; other site
216595020924	active site
216595020925	homodimer interface [polypeptide binding]; other site
216595020927	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
216595020928	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
216595020929	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
216595020931	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
216595020932	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
216595020933	active site
216595020936	PS00072 Acyl-CoA dehydrogenases signature 1.
216595020938	PS00073 Acyl-CoA dehydrogenases signature 2.
216595020939	enoyl-CoA hydratase; Provisional; Region: PRK05995
216595020940	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
216595020941	substrate binding site [chemical binding]; other site
216595020942	oxyanion hole (OAH) forming residues; other site
216595020943	trimer interface [polypeptide binding]; other site
216595020945	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
216595020946	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
216595020947	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
216595020948	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
216595020949	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
216595020950	carboxyltransferase (CT) interaction site; other site
216595020951	biotinylation site [posttranslational modification]; other site
216595020954	PS00866 Carbamoyl-phosphate synthase subdomain signature 1.
216595020955	PS00867 Carbamoyl-phosphate synthase subdomain signature 2.
216595020957	PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide.
216595020959	PS00188 Biotin-requiring enzymes attachment site.
216595020960	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
216595020961	active site
216595020962	catalytic site [active]
216595020963	substrate binding site [chemical binding]; other site
216595020965	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
216595020967	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
216595020968	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
216595020969	MOSC domain; Region: MOSC; pfam03473
216595020972	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
216595020973	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
216595020974	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595020975	active site
216595020976	phosphorylation site [posttranslational modification]
216595020977	intermolecular recognition site; other site
216595020978	dimerization interface [polypeptide binding]; other site
216595020981	low G+C content region (41.84%)
216595020982	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
216595020983	Histidine kinase; Region: HisKA_3; pfam07730
216595020984	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595020985	ATP binding site [chemical binding]; other site
216595020986	Mg2+ binding site [ion binding]; other site
216595020987	G-X-G motif; other site
216595020988	2 probable transmembrane helices predicted for PFLU4403 by TMHMM2.0 at aa 53-70 and 75-92
216595020991	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
216595020992	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595020993	active site
216595020994	phosphorylation site [posttranslational modification]
216595020995	intermolecular recognition site; other site
216595020996	dimerization interface [polypeptide binding]; other site
216595020997	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216595020998	DNA binding residues [nucleotide binding]
216595020999	dimerization interface [polypeptide binding]; other site
216595021002	lipid kinase; Reviewed; Region: PRK13054
216595021003	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
216595021005	Protein of unknown function (DUF2802); Region: DUF2802; pfam10975
216595021006	1 probable transmembrane helix predicted for PFLU4406 by TMHMM2.0 at aa 5-22
216595021007	chemotaxis gene cluster
216595021008	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
216595021009	putative CheA interaction surface; other site
216595021011	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
216595021013	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
216595021014	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
216595021015	P-loop; other site
216595021016	Magnesium ion binding site [ion binding]; other site
216595021017	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
216595021018	Magnesium ion binding site [ion binding]; other site
216595021020	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
216595021021	flagellar motor protein MotD; Reviewed; Region: PRK09038
216595021022	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
216595021023	ligand binding site [chemical binding]; other site
216595021025	1 probable transmembrane helix predicted for PFLU4410 by TMHMM2.0 at aa 19-41
216595021026	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
216595021027	flagellar motor protein; Reviewed; Region: motC; PRK09109
216595021029	PS00622 Bacterial regulatory proteins, luxR family signature.
216595021030	Response regulator receiver domain; Region: Response_reg; pfam00072
216595021031	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595021032	active site
216595021033	phosphorylation site [posttranslational modification]
216595021034	intermolecular recognition site; other site
216595021035	dimerization interface [polypeptide binding]; other site
216595021036	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
216595021037	CheB methylesterase; Region: CheB_methylest; pfam01339
216595021040	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
216595021041	putative binding surface; other site
216595021042	active site
216595021043	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
216595021044	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
216595021045	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595021046	ATP binding site [chemical binding]; other site
216595021047	Mg2+ binding site [ion binding]; other site
216595021048	G-X-G motif; other site
216595021049	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
216595021051	PS00018 EF-hand calcium-binding domain.
216595021055	Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344
216595021057	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
216595021058	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595021059	active site
216595021060	phosphorylation site [posttranslational modification]
216595021061	intermolecular recognition site; other site
216595021062	dimerization interface [polypeptide binding]; other site
216595021064	flagella biosynthesis gene cluster
216595021065	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
216595021066	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
216595021067	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
216595021068	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
216595021069	DNA binding residues [nucleotide binding]
216595021073	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
216595021074	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
216595021075	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
216595021077	PS00017 ATP/GTP-binding site motif A (P-loop).
216595021078	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
216595021079	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
216595021081	PS00017 ATP/GTP-binding site motif A (P-loop).
216595021082	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
216595021083	FHIPEP family; Region: FHIPEP; pfam00771
216595021085	PS00994 Bacterial export FHIPEP family signature.
216595021086	low G+C content region (51.91%)
216595021087	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
216595021088	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
216595021090	PS00678 Trp-Asp (WD) repeats signature.
216595021091	PS00639 Eukaryotic thiol (cysteine) proteases histidine active site.
216595021092	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
216595021094	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
216595021096	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
216595021098	PS01061 Flagella transport protein fliP family signature 2.
216595021099	PS01060 Flagella transport protein fliP family signature 1.
216595021100	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
216595021102	1 probable transmembrane helix predicted for PFLU4426 by TMHMM2.0 at aa 38-60
216595021103	flagellar motor switch protein; Validated; Region: fliN; PRK05698
216595021104	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
216595021106	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
216595021107	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
216595021110	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK05696
216595021112	1 probable transmembrane helix predicted for PFLU4429 by TMHMM2.0 at aa 20-42
216595021113	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
216595021115	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
216595021116	putative binding surface; other site
216595021117	active site
216595021119	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595021120	Response regulator receiver domain; Region: Response_reg; pfam00072
216595021121	active site
216595021122	phosphorylation site [posttranslational modification]
216595021123	intermolecular recognition site; other site
216595021124	dimerization interface [polypeptide binding]; other site
216595021125	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
216595021126	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
216595021127	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595021128	ATP binding site [chemical binding]; other site
216595021129	Mg2+ binding site [ion binding]; other site
216595021130	G-X-G motif; other site
216595021134	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
216595021135	anti sigma factor interaction site; other site
216595021136	regulatory phosphorylation site [posttranslational modification]; other site
216595021138	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
216595021139	flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473
216595021140	flagellum-specific ATP synthase; Validated; Region: fliI; PRK05688
216595021141	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
216595021142	Walker A motif/ATP binding site; other site
216595021143	Walker B motif; other site
216595021145	PS00152 ATP synthase alpha and beta subunits signature.
216595021146	PS00017 ATP/GTP-binding site motif A (P-loop).
216595021147	flagellar assembly protein H; Validated; Region: fliH; PRK05687
216595021148	Flagellar assembly protein FliH; Region: FliH; pfam02108
216595021150	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
216595021151	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
216595021152	MgtE intracellular N domain; Region: MgtE_N; smart00924
216595021153	FliG C-terminal domain; Region: FliG_C; pfam01706
216595021155	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
216595021156	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
216595021157	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
216595021160	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253
216595021162	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
216595021163	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595021164	active site
216595021165	phosphorylation site [posttranslational modification]
216595021166	intermolecular recognition site; other site
216595021167	dimerization interface [polypeptide binding]; other site
216595021168	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595021169	Walker A motif; other site
216595021170	ATP binding site [chemical binding]; other site
216595021171	Walker B motif; other site
216595021172	arginine finger; other site
216595021173	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
216595021174	putative DNA binding site [nucleotide binding]; other site
216595021175	putative Zn2+ binding site [ion binding]; other site
216595021177	PS00688 Sigma-54 interaction domain C-terminal part signature.
216595021179	PS00676 Sigma-54 interaction domain ATP-binding region B signature.
216595021180	PS00675 Sigma-54 interaction domain ATP-binding region A signature.
216595021182	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
216595021183	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595021184	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595021185	dimer interface [polypeptide binding]; other site
216595021186	phosphorylation site [posttranslational modification]
216595021187	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595021188	ATP binding site [chemical binding]; other site
216595021189	Mg2+ binding site [ion binding]; other site
216595021190	G-X-G motif; other site
216595021194	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
216595021195	Flagellar regulatory protein FleQ; Region: FleQ; pfam06490
216595021196	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595021197	Walker A motif; other site
216595021198	ATP binding site [chemical binding]; other site
216595021199	Walker B motif; other site
216595021200	arginine finger; other site
216595021201	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
216595021203	PS00688 Sigma-54 interaction domain C-terminal part signature.
216595021205	PS00676 Sigma-54 interaction domain ATP-binding region B signature.
216595021206	PS00675 Sigma-54 interaction domain ATP-binding region A signature.
216595021208	flagellar protein FliS; Validated; Region: fliS; PRK05685
216595021210	Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345
216595021211	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
216595021212	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
216595021216	FlaG protein; Region: FlaG; pfam03646
216595021218	flagellin; Provisional; Region: PRK12806
216595021219	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
216595021220	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
216595021225	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
216595021226	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
216595021227	dimer interface [polypeptide binding]; other site
216595021228	active site
216595021229	CoA binding pocket [chemical binding]; other site
216595021232	PS00017 ATP/GTP-binding site motif A (P-loop).
216595021233	flagellar hook-associated protein FlgL; Provisional; Region: flgL; PRK12717
216595021234	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
216595021235	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
216595021237	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK05683
216595021238	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
216595021239	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
216595021242	PS00588 Flagella basal body rod proteins signature.
216595021243	Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951
216595021244	flagellar rod assembly protein/muramidase FlgJ; Provisional; Region: flgJ; PRK12713
216595021245	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
216595021247	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
216595021248	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
216595021250	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698
216595021251	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
216595021253	PS00017 ATP/GTP-binding site motif A (P-loop).
216595021254	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595021255	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
216595021256	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
216595021257	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
216595021260	PS00588 Flagella basal body rod proteins signature.
216595021261	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
216595021262	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
216595021263	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
216595021265	Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283
216595021266	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
216595021267	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595021268	putative active site [active]
216595021269	heme pocket [chemical binding]; other site
216595021270	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595021271	Walker A motif; other site
216595021272	ATP binding site [chemical binding]; other site
216595021273	Walker B motif; other site
216595021274	arginine finger; other site
216595021275	Helix-turn-helix domain; Region: HTH_38; pfam13936
216595021276	PS00688 Sigma-54 interaction domain C-terminal part signature.
216595021278	PS00675 Sigma-54 interaction domain ATP-binding region A signature.
216595021280	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
216595021281	cofactor binding site; other site
216595021282	metal binding site [ion binding]; metal-binding site
216595021284	PS00367 Biopterin-dependent aromatic amino acid hydroxylases signature.
216595021285	pterin-4-alpha-carbinolamine dehydratase; Validated; Region: phhB; PRK00823
216595021286	aromatic arch; other site
216595021287	DCoH dimer interaction site [polypeptide binding]; other site
216595021288	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
216595021289	DCoH tetramer interaction site [polypeptide binding]; other site
216595021290	substrate binding site [chemical binding]; other site
216595021292	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
216595021293	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216595021294	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595021295	homodimer interface [polypeptide binding]; other site
216595021296	catalytic residue [active]
216595021298	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
216595021299	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
216595021300	putative active site [active]
216595021301	putative metal binding site [ion binding]; other site
216595021303	Cupin domain; Region: Cupin_2; cl17218
216595021304	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
216595021305	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595021308	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
216595021309	EamA-like transporter family; Region: EamA; pfam00892
216595021310	10 probable transmembrane helices predicted for PFLU4463 by TMHMM2.0 at aa 7-29, 33-55, 68-87, 92-114, 121-138, 148-165, 177-199, 209-231, 238-257 and 262-284
216595021313	PS00089 Ribonucleotide reductase large subunit signature.
216595021314	PS00626 Regulator of chromosome condensation (RCC1) signature 2.
216595021315	3 probable transmembrane helices predicted for PFLU4464 by TMHMM2.0 at aa 10-32, 44-66 and 76-98
216595021316	Uncharacterized protein conserved in bacteria [Posttranslational modification, protein turnover, chaperones]; Region: COG3526
216595021318	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
216595021319	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
216595021320	active site
216595021321	nucleophile elbow; other site
216595021322	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
216595021323	Surface antigen; Region: Bac_surface_Ag; pfam01103
216595021327	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
216595021328	MarR family; Region: MarR_2; pfam12802
216595021330	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
216595021331	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
216595021332	ATP binding site [chemical binding]; other site
216595021333	putative Mg++ binding site [ion binding]; other site
216595021334	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
216595021335	nucleotide binding region [chemical binding]; other site
216595021336	ATP-binding site [chemical binding]; other site
216595021337	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
216595021338	HRDC domain; Region: HRDC; pfam00570
216595021342	Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318
216595021343	yecA family protein; Region: ygfB_yecA; TIGR02292
216595021344	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
216595021345	2 probable transmembrane helices predicted for PFLU4470 by TMHMM2.0 at aa 12-34 and 86-108
216595021347	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
216595021348	Na binding site [ion binding]; other site
216595021349	PAS domain; Region: PAS; smart00091
216595021350	PAS fold; Region: PAS_7; pfam12860
216595021351	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
216595021352	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595021353	dimer interface [polypeptide binding]; other site
216595021354	phosphorylation site [posttranslational modification]
216595021355	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595021356	ATP binding site [chemical binding]; other site
216595021357	Mg2+ binding site [ion binding]; other site
216595021358	G-X-G motif; other site
216595021359	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
216595021360	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595021361	active site
216595021362	phosphorylation site [posttranslational modification]
216595021363	intermolecular recognition site; other site
216595021364	dimerization interface [polypeptide binding]; other site
216595021365	12 probable transmembrane helices predicted for PFLU4471 by TMHMM2.0 at aa 4-26, 39-61, 65-87, 115-134, 161-178, 191-213, 247-266, 279-301, 329-351, 382-401, 411-433 and 440-462
216595021370	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
216595021371	RmuC family; Region: RmuC; pfam02646
216595021373	1 probable transmembrane helix predicted for PFLU4472 by TMHMM2.0 at aa 13-32
216595021374	3 probable transmembrane helices predicted for PFLU4474 by TMHMM2.0 at aa 36-58, 63-85 and 106-128
216595021375	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
216595021377	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
216595021378	catalytic residues [active]
216595021379	dimer interface [polypeptide binding]; other site
216595021381	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595021382	Major Facilitator Superfamily; Region: MFS_1; pfam07690
216595021383	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595021385	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
216595021386	MarR family; Region: MarR_2; pfam12802
216595021388	cobalamin synthase; Reviewed; Region: cobS; PRK00235
216595021390	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595021391	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
216595021392	catalytic core [active]
216595021394	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
216595021395	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
216595021396	putative dimer interface [polypeptide binding]; other site
216595021397	active site pocket [active]
216595021398	putative cataytic base [active]
216595021400	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595021401	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
216595021402	homotrimer interface [polypeptide binding]; other site
216595021403	Walker A motif; other site
216595021404	GTP binding site [chemical binding]; other site
216595021406	PS00017 ATP/GTP-binding site motif A (P-loop).
216595021407	gcgggnnnncccgc
216595021408	gcgggnnnncccgc
216595021409	gcgggnnnncccgc
216595021410	gcgggnnnncccgc
216595021411	cobyric acid synthase; Provisional; Region: PRK00784
216595021412	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
216595021413	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
216595021414	catalytic triad [active]
216595021417	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
216595021418	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216595021419	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595021420	homodimer interface [polypeptide binding]; other site
216595021421	catalytic residue [active]
216595021423	PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site.
216595021424	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
216595021426	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
216595021427	FMN binding site [chemical binding]; other site
216595021428	dimer interface [polypeptide binding]; other site
216595021430	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
216595021431	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
216595021432	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
216595021433	catalytic triad [active]
216595021436	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
216595021437	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
216595021438	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
216595021439	Walker A motif; other site
216595021440	homodimer interface [polypeptide binding]; other site
216595021441	ATP binding site [chemical binding]; other site
216595021442	hydroxycobalamin binding site [chemical binding]; other site
216595021443	Walker B motif; other site
216595021445	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
216595021446	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595021449	PS00133 Zinc carboxypeptidases, zinc-binding region 2 signature.
216595021451	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
216595021452	NlpC/P60 family; Region: NLPC_P60; pfam00877
216595021454	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595021455	NlpC/P60 family; Region: NLPC_P60; pfam00877
216595021457	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595021458	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
216595021459	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595021460	Walker A motif; other site
216595021461	ATP binding site [chemical binding]; other site
216595021462	Walker B motif; other site
216595021463	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
216595021464	arginine finger; other site
216595021466	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
216595021467	Domain of unknown function DUF20; Region: UPF0118; pfam01594
216595021469	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3249
216595021470	Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839
216595021471	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
216595021472	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
216595021473	dimerization interface [polypeptide binding]; other site
216595021474	putative ATP binding site [chemical binding]; other site
216595021477	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
216595021478	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
216595021479	active site
216595021480	substrate binding site [chemical binding]; other site
216595021481	cosubstrate binding site; other site
216595021482	catalytic site [active]
216595021484	PS00373 Phosphoribosylglycinamide formyltransferase active site.
216595021485	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
216595021486	PS00052 Ribosomal protein S7 signature.
216595021487	Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831
216595021488	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
216595021489	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
216595021490	homodimer interface [polypeptide binding]; other site
216595021491	metal binding site [ion binding]; metal-binding site
216595021492	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
216595021493	homodimer interface [polypeptide binding]; other site
216595021494	active site
216595021495	putative chemical substrate binding site [chemical binding]; other site
216595021496	metal binding site [ion binding]; metal-binding site
216595021499	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
216595021500	HD domain; Region: HD_4; pfam13328
216595021501	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
216595021502	synthetase active site [active]
216595021503	NTP binding site [chemical binding]; other site
216595021504	metal binding site [ion binding]; metal-binding site
216595021505	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
216595021506	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
216595021507	active site
216595021508	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
216595021512	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
216595021513	TRAM domain; Region: TRAM; pfam01938
216595021514	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595021515	S-adenosylmethionine binding site [chemical binding]; other site
216595021516	PS01231 RNA methyltransferase trmA family signature 2.
216595021517	PS01230 RNA methyltransferase trmA family signature 1.
216595021520	cysteine synthase B; Region: cysM; TIGR01138
216595021521	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
216595021522	dimer interface [polypeptide binding]; other site
216595021523	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595021524	catalytic residue [active]
216595021526	PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site.
216595021527	Uncharacterized conserved protein [Function unknown]; Region: COG3148
216595021529	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595021530	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595021531	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
216595021532	dimerization interface [polypeptide binding]; other site
216595021535	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
216595021536	agmatinase; Region: agmatinase; TIGR01230
216595021537	oligomer interface [polypeptide binding]; other site
216595021538	putative active site [active]
216595021539	Mn binding site [ion binding]; other site
216595021541	PS00147 Arginase family signature 1.
216595021542	PS00148 Arginase family signature 2.
216595021543	PS01053 Arginase family signature 3.
216595021544	SnoaL-like domain; Region: SnoaL_4; cl17707
216595021545	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
216595021546	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
216595021547	Na binding site [ion binding]; other site
216595021549	12 probable transmembrane helices predicted for PFLU4512 by TMHMM2.0 at aa 36-58, 63-85, 106-128, 148-170, 177-196, 211-233, 254-276, 291-313, 334-356, 366-388, 420-442 and 452-474
216595021550	13 probable transmembrane helices predicted for PFLU4513 by TMHMM2.0 at aa 35-57, 78-100, 105-127, 155-177, 187-209, 216-238, 253-275, 296-318, 341-363, 384-406, 411-433, 440-457 and 467-484
216595021551	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479
216595021552	Na binding site [ion binding]; other site
216595021554	PS00044 Bacterial regulatory proteins, lysR family signature.
216595021555	1 probable transmembrane helix predicted for PFLU4514 by TMHMM2.0 at aa 21-43
216595021556	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595021557	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595021558	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
216595021559	putative dimerization interface [polypeptide binding]; other site
216595021562	PS00044 Bacterial regulatory proteins, lysR family signature.
216595021563	Protein of unknown function (DUF1228); Region: DUF1228; pfam06779
216595021564	12 probable transmembrane helices predicted for PFLU4517 by TMHMM2.0 at aa 7-26, 41-63, 75-92, 102-124, 131-153, 163-182, 203-225, 235-257, 270-287, 291-313, 326-348 and 353-375
216595021566	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
216595021567	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
216595021568	Na binding site [ion binding]; other site
216595021569	putative substrate binding site [chemical binding]; other site
216595021570	PS00017 ATP/GTP-binding site motif A (P-loop).
216595021572	Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945
216595021573	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
216595021574	S1 domain; Region: S1_2; pfam13509
216595021575	S1 domain; Region: S1_2; pfam13509
216595021576	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
216595021577	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
216595021578	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595021579	1 probable transmembrane helix predicted for PFLU4523 by TMHMM2.0 at aa 17-36
216595021580	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595021581	Protein of unknown function (DUF3373); Region: DUF3373; pfam11853
216595021582	helicase 45; Provisional; Region: PTZ00424
216595021583	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
216595021584	ATP binding site [chemical binding]; other site
216595021585	Mg++ binding site [ion binding]; other site
216595021586	motif III; other site
216595021587	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
216595021588	nucleotide binding region [chemical binding]; other site
216595021589	ATP-binding site [chemical binding]; other site
216595021592	PS00039 DEAD-box subfamily ATP-dependent helicases signature.
216595021593	PS00041 Bacterial regulatory proteins, araC family signature.
216595021594	PS00017 ATP/GTP-binding site motif A (P-loop).
216595021595	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
216595021596	Mechanosensitive ion channel; Region: MS_channel; pfam00924
216595021597	4 probable transmembrane helices predicted for PFLU4527 by TMHMM2.0 at aa 45-67, 124-146, 166-188 and 193-210
216595021599	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
216595021602	azoreductase; Reviewed; Region: PRK00170
216595021603	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
216595021605	1 probable transmembrane helix predicted for PFLU4530 by TMHMM2.0 at aa 20-37
216595021606	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595021607	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595021608	LysR substrate binding domain; Region: LysR_substrate; pfam03466
216595021609	dimerization interface [polypeptide binding]; other site
216595021612	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
216595021613	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
216595021614	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
216595021616	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
216595021617	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
216595021618	active site
216595021620	PS00170 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature.
216595021621	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
216595021622	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
216595021623	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216595021624	Walker A/P-loop; other site
216595021625	ATP binding site [chemical binding]; other site
216595021626	Q-loop/lid; other site
216595021627	ABC transporter signature motif; other site
216595021628	Walker B; other site
216595021629	D-loop; other site
216595021630	H-loop/switch region; other site
216595021631	6 probable transmembrane helices predicted for PFLU4534 by TMHMM2.0 at aa 39-61, 76-98, 157-179, 183-205, 271-293 and 297-319
216595021633	PS00017 ATP/GTP-binding site motif A (P-loop).
216595021634	PS00211 ABC transporters family signature.
216595021635	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
216595021636	Protein of unknown function, DUF482; Region: DUF482; pfam04339
216595021638	1 probable transmembrane helix predicted for PFLU4536 by TMHMM2.0 at aa 35-54
216595021639	Putative zinc-finger; Region: zf-HC2; pfam13490
216595021640	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
216595021641	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
216595021642	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
216595021643	DNA binding residues [nucleotide binding]
216595021646	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515
216595021647	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
216595021648	dimer interface [polypeptide binding]; other site
216595021649	active site
216595021650	CoA binding pocket [chemical binding]; other site
216595021653	PS00606 Beta-ketoacyl synthases active site.
216595021654	PS00017 ATP/GTP-binding site motif A (P-loop).
216595021655	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
216595021656	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
216595021657	ATP binding site [chemical binding]; other site
216595021658	putative Mg++ binding site [ion binding]; other site
216595021659	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
216595021660	nucleotide binding region [chemical binding]; other site
216595021661	ATP-binding site [chemical binding]; other site
216595021662	Helicase associated domain (HA2); Region: HA2; pfam04408
216595021663	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
216595021664	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
216595021668	PS00017 ATP/GTP-binding site motif A (P-loop).
216595021669	bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946
216595021670	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
216595021672	PS00017 ATP/GTP-binding site motif A (P-loop).
216595021673	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
216595021674	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
216595021675	dimerization interface [polypeptide binding]; other site
216595021676	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
216595021677	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595021678	dimer interface [polypeptide binding]; other site
216595021679	putative CheW interface [polypeptide binding]; other site
216595021680	2 probable transmembrane helices predicted for PFLU4548 by TMHMM2.0 at aa 10-32 and 190-212
216595021683	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
216595021684	EamA-like transporter family; Region: EamA; pfam00892
216595021685	EamA-like transporter family; Region: EamA; pfam00892
216595021686	10 probable transmembrane helices predicted for PFLU4549 by TMHMM2.0 at aa 13-32, 42-59, 72-94, 98-120, 127-149, 153-175, 188-210, 220-242, 249-271 and 276-295
216595021689	CAAX protease self-immunity; Region: Abi; pfam02517
216595021690	8 probable transmembrane helices predicted for PFLU4550 by TMHMM2.0 at aa 19-41, 45-67, 74-96, 126-143, 150-172, 182-201, 222-244 and 259-281
216595021691	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595021693	PAS domain; Region: PAS_9; pfam13426
216595021694	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595021695	putative active site [active]
216595021696	heme pocket [chemical binding]; other site
216595021697	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
216595021698	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595021699	dimer interface [polypeptide binding]; other site
216595021700	putative CheW interface [polypeptide binding]; other site
216595021703	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571
216595021704	Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752
216595021705	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
216595021706	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
216595021707	Low-spin heme binding site [chemical binding]; other site
216595021708	Putative water exit pathway; other site
216595021709	Binuclear center (active site) [active]
216595021710	Putative proton exit pathway; other site
216595021711	12 probable transmembrane helices predicted for PFLU4553 by TMHMM2.0 at aa 51-73, 88-110, 123-142, 157-179, 191-213, 233-255, 268-285, 300-322, 335-357, 372-394, 407-429 and 463-485
216595021713	PS00077 Heme-copper oxidase catalytic subunit, copper B binding region signature.
216595021714	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
216595021715	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
216595021717	1 probable transmembrane helix predicted for PFLU4554 by TMHMM2.0 at aa 13-35
216595021718	PS00190 Cytochrome c family heme-binding site signature.
216595021719	Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545
216595021720	1 probable transmembrane helix predicted for PFLU4555 by TMHMM2.0 at aa 10-32
216595021721	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
216595021722	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
216595021723	Cytochrome c; Region: Cytochrom_C; cl11414
216595021724	2 probable transmembrane helices predicted for PFLU4556 by TMHMM2.0 at aa 4-26 and 57-79
216595021726	PS00190 Cytochrome c family heme-binding site signature.
216595021728	PS00190 Cytochrome c family heme-binding site signature.
216595021729	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
216595021730	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
216595021731	Low-spin heme binding site [chemical binding]; other site
216595021732	Putative water exit pathway; other site
216595021733	Binuclear center (active site) [active]
216595021734	Putative proton exit pathway; other site
216595021735	12 probable transmembrane helices predicted for PFLU4558 by TMHMM2.0 at aa 45-67, 87-109, 122-141, 156-178, 185-207, 233-255, 262-284, 299-321, 334-356, 371-393, 406-428 and 462-484
216595021737	PS00077 Heme-copper oxidase catalytic subunit, copper B binding region signature.
216595021738	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
216595021739	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
216595021741	1 probable transmembrane helix predicted for PFLU4559 by TMHMM2.0 at aa 12-34
216595021742	PS00190 Cytochrome c family heme-binding site signature.
216595021743	PS00017 ATP/GTP-binding site motif A (P-loop).
216595021744	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
216595021746	1 probable transmembrane helix predicted for PFLU4560 by TMHMM2.0 at aa 4-26
216595021747	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
216595021748	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
216595021749	Cytochrome c; Region: Cytochrom_C; pfam00034
216595021750	2 probable transmembrane helices predicted for PFLU4561 by TMHMM2.0 at aa 4-26 and 57-79
216595021752	PS00190 Cytochrome c family heme-binding site signature.
216595021754	PS00190 Cytochrome c family heme-binding site signature.
216595021755	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
216595021756	4Fe-4S binding domain; Region: Fer4_5; pfam12801
216595021757	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
216595021758	5 probable transmembrane helices predicted for PFLU4563 by TMHMM2.0 at aa 46-68, 94-116, 169-188, 203-222 and 343-362
216595021760	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
216595021761	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198
216595021762	FixH; Region: FixH; pfam05751
216595021763	1 probable transmembrane helix predicted for PFLU4564 by TMHMM2.0 at aa 15-37
216595021764	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
216595021765	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
216595021766	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
216595021767	metal-binding site [ion binding]
216595021768	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
216595021769	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216595021770	motif II; other site
216595021771	7 probable transmembrane helices predicted for PFLU4565 by TMHMM2.0 at aa 173-195, 210-232, 245-267, 272-290, 425-447, 452-471 and 752-774
216595021774	PS00154 E1-E2 ATPases phosphorylation site.
216595021775	PS01229 Hypothetical cof family signature 2.
216595021776	Uncharacterized protein, possibly involved in nitrogen fixation [Inorganic ion transport and metabolism]; Region: FixS; COG3197
216595021778	1 probable transmembrane helix predicted for PFLU4566 by TMHMM2.0 at aa 5-27
216595021779	Uncharacterized conserved protein [Function unknown]; Region: COG2836
216595021780	6 probable transmembrane helices predicted for PFLU4567 by TMHMM2.0 at aa 15-37, 49-71, 81-103, 135-157, 167-189 and 202-224
216595021781	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
216595021782	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216595021783	FeS/SAM binding site; other site
216595021784	HemN C-terminal domain; Region: HemN_C; pfam06969
216595021787	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
216595021788	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
216595021789	ligand binding site [chemical binding]; other site
216595021790	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
216595021791	putative switch regulator; other site
216595021792	non-specific DNA interactions [nucleotide binding]; other site
216595021793	DNA binding site [nucleotide binding]
216595021794	sequence specific DNA binding site [nucleotide binding]; other site
216595021795	putative cAMP binding site [chemical binding]; other site
216595021798	PS00042 Bacterial regulatory proteins, crp family signature.
216595021799	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
216595021800	active site
216595021802	PS00103 Purine/pyrimidine phosphoribosyl transferases signature.
216595021803	Transposase; Region: DEDD_Tnp_IS110; pfam01548
216595021804	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
216595021805	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
216595021808	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
216595021809	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
216595021810	active site
216595021813	PS00072 Acyl-CoA dehydrogenases signature 1.
216595021815	recombination protein RecR; Reviewed; Region: recR; PRK00076
216595021816	RecR protein; Region: RecR; pfam02132
216595021817	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
216595021818	putative active site [active]
216595021819	putative metal-binding site [ion binding]; other site
216595021820	tetramer interface [polypeptide binding]; other site
216595021823	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
216595021824	Prostaglandin dehydrogenases; Region: PGDH; cd05288
216595021825	NAD(P) binding site [chemical binding]; other site
216595021826	substrate binding site [chemical binding]; other site
216595021827	dimer interface [polypeptide binding]; other site
216595021829	hypothetical protein; Validated; Region: PRK00153
216595021831	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
216595021832	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595021833	Walker A motif; other site
216595021834	ATP binding site [chemical binding]; other site
216595021835	Walker B motif; other site
216595021836	arginine finger; other site
216595021837	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
216595021839	PS00017 ATP/GTP-binding site motif A (P-loop).
216595021840	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
216595021841	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
216595021842	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261
216595021843	putative dimer interface [polypeptide binding]; other site
216595021845	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
216595021846	EamA-like transporter family; Region: EamA; pfam00892
216595021847	EamA-like transporter family; Region: EamA; pfam00892
216595021850	PS00211 ABC transporters family signature.
216595021851	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595021852	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595021853	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
216595021854	dimerization interface [polypeptide binding]; other site
216595021856	PS00044 Bacterial regulatory proteins, lysR family signature.
216595021858	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595021859	Protein of unknown function (DUF3380); Region: DUF3380; pfam11860
216595021860	AAA domain; Region: AAA_30; pfam13604
216595021861	PS00017 ATP/GTP-binding site motif A (P-loop).
216595021862	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
216595021863	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
216595021864	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
216595021865	Ligase N family; Region: LIGANc; smart00532
216595021866	nucleotide binding pocket [chemical binding]; other site
216595021867	K-X-D-G motif; other site
216595021868	catalytic site [active]
216595021869	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
216595021870	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
216595021871	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
216595021872	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
216595021873	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
216595021874	Dimer interface [polypeptide binding]; other site
216595021877	PS01056 NAD-dependent DNA ligase signature 2.
216595021879	PS01055 NAD-dependent DNA ligase signature 1.
216595021880	cell division protein ZipA; Reviewed; Region: zipA; PRK00269
216595021881	Cell division protein [Cell division and chromosome partitioning]; Region: ZipA; COG3115
216595021882	FtsZ protein binding site [polypeptide binding]; other site
216595021884	1 probable transmembrane helix predicted for PFLU4589 by TMHMM2.0 at aa 7-25
216595021885	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
216595021886	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
216595021887	Walker A/P-loop; other site
216595021888	ATP binding site [chemical binding]; other site
216595021889	Q-loop/lid; other site
216595021890	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
216595021891	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
216595021892	ABC transporter signature motif; other site
216595021893	Walker B; other site
216595021894	D-loop; other site
216595021895	H-loop/switch region; other site
216595021898	PS00017 ATP/GTP-binding site motif A (P-loop).
216595021899	Transcriptional regulators [Transcription]; Region: GntR; COG1802
216595021900	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595021901	DNA-binding site [nucleotide binding]; DNA binding site
216595021903	PS00043 Bacterial regulatory proteins, gntR family signature.
216595021904	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
216595021905	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
216595021906	catalytic loop [active]
216595021907	iron binding site [ion binding]; other site
216595021908	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
216595021909	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
216595021911	PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature.
216595021915	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
216595021916	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
216595021917	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
216595021920	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595021921	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
216595021922	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
216595021923	XdhC Rossmann domain; Region: XdhC_C; pfam13478
216595021925	guanine deaminase; Provisional; Region: PRK09228
216595021926	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
216595021927	active site
216595021929	Transcriptional regulators [Transcription]; Region: GntR; COG1802
216595021930	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595021931	DNA-binding site [nucleotide binding]; DNA binding site
216595021932	FCD domain; Region: FCD; pfam07729
216595021935	PS00043 Bacterial regulatory proteins, gntR family signature.
216595021936	benzoate transporter; Region: benE; TIGR00843
216595021937	Benzoate membrane transport protein; Region: BenE; pfam03594
216595021939	9 probable transmembrane helices predicted for PFLU4597 by TMHMM2.0 at aa 20-42, 52-74, 94-116, 131-153, 173-195, 210-232, 301-323, 328-347 and 368-390
216595021940	hypothetical protein; Provisional; Region: PRK11702
216595021942	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
216595021943	probable transmembrane helix predicted for PFLU4599 by TMHMM2.0 at aa 7-26
216595021946	CHASE domain; Region: CHASE; pfam03924
216595021947	PAS fold; Region: PAS; pfam00989
216595021948	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595021949	putative active site [active]
216595021950	heme pocket [chemical binding]; other site
216595021951	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595021952	putative active site [active]
216595021953	heme pocket [chemical binding]; other site
216595021954	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
216595021955	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216595021956	metal binding site [ion binding]; metal-binding site
216595021957	active site
216595021958	I-site; other site
216595021963	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
216595021964	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
216595021965	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
216595021966	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595021967	S-adenosylmethionine binding site [chemical binding]; other site
216595021969	PS00092 N-6 Adenine-specific DNA methylases signature.
216595021971	low GC content region (52.4%)
216595021972	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
216595021973	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
216595021974	quinone interaction residues [chemical binding]; other site
216595021975	active site
216595021976	catalytic residues [active]
216595021977	FMN binding site [chemical binding]; other site
216595021978	substrate binding site [chemical binding]; other site
216595021980	PS00911 Dihydroorotate dehydrogenase signature 1.
216595021981	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
216595021982	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
216595021983	N-acetyl-D-glucosamine binding site [chemical binding]; other site
216595021984	catalytic residue [active]
216595021987	type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516
216595021988	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
216595021989	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
216595021992	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
216595021993	NMT1-like family; Region: NMT1_2; pfam13379
216595021994	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
216595021995	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595021996	active site
216595021997	phosphorylation site [posttranslational modification]
216595021998	intermolecular recognition site; other site
216595021999	dimerization interface [polypeptide binding]; other site
216595022000	ANTAR domain; Region: ANTAR; pfam03861
216595022003	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
216595022004	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595022005	putative substrate translocation pore; other site
216595022006	11 probable transmembrane helices predicted for PFLU4609 by TMHMM2.0 at aa 68-90, 103-125, 135-153, 160-182, 192-214, 219-241, 266-288, 326-348, 353-375, 388-410 and 420-439
216595022008	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
216595022009	active site
216595022010	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
216595022011	Catalytic domain of Protein Kinases; Region: PKc; cd00180
216595022012	active site
216595022013	ATP binding site [chemical binding]; other site
216595022014	substrate binding site [chemical binding]; other site
216595022015	activation loop (A-loop); other site
216595022017	1 probable transmembrane helix predicted for PFLU4610 by TMHMM2.0 at aa 532-554
216595022018	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
216595022019	active site
216595022020	SAM binding site [chemical binding]; other site
216595022021	homodimer interface [polypeptide binding]; other site
216595022023	PS00839 Uroporphyrin-III C-methyltransferase signature 1.
216595022024	OprF membrane domain; Region: OprF; pfam05736
216595022025	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
216595022026	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
216595022027	ligand binding site [chemical binding]; other site
216595022029	PS01068 OmpA-like domain.
216595022031	RNA polymerase sigma factor SigX; Reviewed; Region: PRK09640
216595022032	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
216595022033	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
216595022034	DNA binding residues [nucleotide binding]
216595022039	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
216595022040	Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833
216595022041	Cl binding site [ion binding]; other site
216595022042	oligomer interface [polypeptide binding]; other site
216595022044	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595022045	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
216595022047	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
216595022048	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
216595022049	phosphoenolpyruvate synthase; Validated; Region: PRK06464
216595022050	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
216595022051	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
216595022052	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
216595022054	PS00742 PEP-utilizing enzymes signature 2.
216595022056	PS00370 PEP-utilizing enzymes phosphorylation site signature.
216595022058	PS00687 Aldehyde dehydrogenases glutamic acid active site.
216595022059	PEP synthetase regulatory protein; Provisional; Region: PRK05339
216595022061	PS00017 ATP/GTP-binding site motif A (P-loop).
216595022062	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
216595022063	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595022064	DNA-binding site [nucleotide binding]; DNA binding site
216595022065	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216595022066	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595022067	homodimer interface [polypeptide binding]; other site
216595022068	catalytic residue [active]
216595022071	10 probable transmembrane helices predicted for PFLU4623 by TMHMM2.0 at aa 19-41, 56-73, 86-103, 113-133, 138-157, 167-189, 196-218, 233-255, 262-281 and 291-313
216595022072	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
216595022073	EamA-like transporter family; Region: EamA; pfam00892
216595022075	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595022077	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
216595022078	MPN+ (JAMM) motif; other site
216595022079	Zinc-binding site [ion binding]; other site
216595022080	hypothetical protein; Validated; Region: PRK07411
216595022081	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
216595022082	ATP binding site [chemical binding]; other site
216595022083	substrate interface [chemical binding]; other site
216595022084	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
216595022085	active site residue [active]
216595022090	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
216595022091	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
216595022092	dimer interface [polypeptide binding]; other site
216595022093	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595022094	catalytic residue [active]
216595022096	serine O-acetyltransferase; Region: cysE; TIGR01172
216595022097	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
216595022098	trimer interface [polypeptide binding]; other site
216595022099	active site
216595022100	substrate binding site [chemical binding]; other site
216595022101	CoA binding site [chemical binding]; other site
216595022106	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
216595022107	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
216595022110	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
216595022111	2-methylcitrate dehydratase; Region: prpD; TIGR02330
216595022113	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
216595022115	1 probable transmembrane helix predicted for PFLU4629 by TMHMM2.0 at aa 318-340
216595022116	2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333
216595022117	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
216595022118	substrate binding site [chemical binding]; other site
216595022119	ligand binding site [chemical binding]; other site
216595022120	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
216595022121	substrate binding site [chemical binding]; other site
216595022125	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
216595022126	Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108
216595022127	dimer interface [polypeptide binding]; other site
216595022128	active site
216595022129	citrylCoA binding site [chemical binding]; other site
216595022130	oxalacetate/citrate binding site [chemical binding]; other site
216595022131	coenzyme A binding site [chemical binding]; other site
216595022132	catalytic triad [active]
216595022134	PS00480 Citrate synthase signature.
216595022135	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
216595022136	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
216595022137	tetramer interface [polypeptide binding]; other site
216595022138	active site
216595022139	Mg2+/Mn2+ binding site [ion binding]; other site
216595022141	Transcriptional regulators [Transcription]; Region: GntR; COG1802
216595022142	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595022143	DNA-binding site [nucleotide binding]; DNA binding site
216595022144	FCD domain; Region: FCD; pfam07729
216595022147	PS00043 Bacterial regulatory proteins, gntR family signature.
216595022148	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
216595022150	Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400
216595022151	7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402
216595022152	7 probable transmembrane helices predicted for PFLU4635 by TMHMM2.0 at aa 10-32, 313-335, 355-377, 384-406, 416-433, 440-462 and 467-489
216595022153	alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291
216595022155	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
216595022156	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
216595022157	chorismate binding enzyme; Region: Chorismate_bind; cl10555
216595022160	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
216595022161	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
216595022162	Transposase; Region: DEDD_Tnp_IS110; pfam01548
216595022163	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
216595022164	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
216595022167	phosphoserine phosphatase; Provisional; Region: thrH; PRK13582
216595022168	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
216595022170	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
216595022171	Active Sites [active]
216595022173	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
216595022174	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
216595022175	Na binding site [ion binding]; other site
216595022176	putative substrate binding site [chemical binding]; other site
216595022178	12 probable transmembrane helices predicted for PFLU4643 by TMHMM2.0 at aa 80-102, 107-129, 162-184, 199-221, 234-256, 271-293, 306-328, 348-370, 391-413, 417-439, 473-495 and 499-516
216595022179	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
216595022181	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595022182	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595022183	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
216595022184	putative effector binding pocket; other site
216595022185	dimerization interface [polypeptide binding]; other site
216595022188	PS00044 Bacterial regulatory proteins, lysR family signature.
216595022189	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
216595022190	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216595022191	NAD(P) binding site [chemical binding]; other site
216595022192	active site
216595022194	hydrolase; Region: PLN02811
216595022195	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216595022196	motif II; other site
216595022198	Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861
216595022199	2 probable transmembrane helices predicted for PFLU4648 by TMHMM2.0 at aa 13-32 and 96-118
216595022200	Domain of unknown function (DUF4337); Region: DUF4337; pfam14235
216595022201	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
216595022202	EamA-like transporter family; Region: EamA; pfam00892
216595022203	EamA-like transporter family; Region: EamA; pfam00892
216595022204	10 probable transmembrane helices predicted for PFLU4651 by TMHMM2.0 at aa 5-22, 27-49, 69-91, 95-117, 124-141, 146-165, 178-200, 210-232, 241-260 and 265-282
216595022207	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
216595022208	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
216595022210	Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341
216595022212	gamma-butyrobetaine hydroxylase; Region: carnitine_bodg; TIGR02409
216595022213	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250
216595022214	substrate binding pocket [chemical binding]; other site
216595022215	active site
216595022216	iron coordination sites [ion binding]; other site
216595022218	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
216595022219	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595022220	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
216595022221	dimerization interface [polypeptide binding]; other site
216595022223	PS00044 Bacterial regulatory proteins, lysR family signature.
216595022225	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
216595022226	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
216595022227	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
216595022228	substrate binding site [chemical binding]; other site
216595022229	oxyanion hole (OAH) forming residues; other site
216595022230	trimer interface [polypeptide binding]; other site
216595022232	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
216595022233	putative acyl-acceptor binding pocket; other site
216595022234	1 probable transmembrane helix predicted for PFLU4658 by TMHMM2.0 at aa 22-44
216595022236	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
216595022237	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
216595022238	oligomer interface [polypeptide binding]; other site
216595022239	metal binding site [ion binding]; metal-binding site
216595022240	metal binding site [ion binding]; metal-binding site
216595022241	putative Cl binding site [ion binding]; other site
216595022242	basic sphincter; other site
216595022243	hydrophobic gate; other site
216595022244	periplasmic entrance; other site
216595022246	2 probable transmembrane helices predicted for PFLU4659 by TMHMM2.0 at aa 266-285 and 295-317
216595022247	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
216595022248	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
216595022249	catalytic triad [active]
216595022251	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
216595022252	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
216595022253	substrate binding site [chemical binding]; other site
216595022254	oxyanion hole (OAH) forming residues; other site
216595022255	trimer interface [polypeptide binding]; other site
216595022256	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
216595022257	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
216595022261	PS00166 Enoyl-CoA hydratase/isomerase signature.
216595022262	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
216595022263	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
216595022264	dimer interface [polypeptide binding]; other site
216595022265	active site
216595022267	PS00099 Thiolases active site.
216595022268	PS00737 Thiolases signature 2.
216595022270	PS00098 Thiolases acyl-enzyme intermediate signature.
216595022271	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
216595022272	Cytochrome c; Region: Cytochrom_C; pfam00034
216595022273	PS00190 Cytochrome c family heme-binding site signature.
216595022274	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
216595022275	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
216595022276	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
216595022279	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
216595022280	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
216595022282	Uncharacterized conserved protein [Function unknown]; Region: COG2308
216595022285	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
216595022287	Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876
216595022288	putative lipid binding site [chemical binding]; other site
216595022290	Flagellin N-methylase; Region: FliB; cl00497
216595022292	1 probable transmembrane helix predicted for PFLU4671 by TMHMM2.0 at aa 7-29
216595022293	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
216595022294	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595022295	DNA-binding site [nucleotide binding]; DNA binding site
216595022296	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216595022297	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595022298	homodimer interface [polypeptide binding]; other site
216595022299	catalytic residue [active]
216595022302	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
216595022303	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
216595022304	ligand binding site [chemical binding]; other site
216595022306	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595022307	Domain of unknown function (DUF4398); Region: DUF4398; pfam14346
216595022308	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595022309	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
216595022310	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595022311	substrate binding pocket [chemical binding]; other site
216595022312	membrane-bound complex binding site; other site
216595022313	hinge residues; other site
216595022314	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
216595022315	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
216595022316	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
216595022317	PS00696 Electron transfer flavoprotein alpha-subunit signature.
216595022320	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
216595022321	Ligand binding site [chemical binding]; other site
216595022322	Electron transfer flavoprotein domain; Region: ETF; pfam01012
216595022324	PS01065 Electron transfer flavoprotein beta-subunit signature.
216595022325	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
216595022326	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
216595022327	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
216595022330	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
216595022331	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
216595022332	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595022333	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595022335	PS00041 Bacterial regulatory proteins, araC family signature.
216595022338	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
216595022339	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
216595022340	putative NAD(P) binding site [chemical binding]; other site
216595022341	putative substrate binding site [chemical binding]; other site
216595022342	catalytic Zn binding site [ion binding]; other site
216595022343	structural Zn binding site [ion binding]; other site
216595022344	dimer interface [polypeptide binding]; other site
216595022346	PS00190 Cytochrome c family heme-binding site signature.
216595022347	PS00059 Zinc-containing alcohol dehydrogenases signature.
216595022349	PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature.
216595022350	Transcriptional regulator [Transcription]; Region: IclR; COG1414
216595022351	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
216595022352	Bacterial transcriptional regulator; Region: IclR; pfam01614
216595022355	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
216595022356	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
216595022357	TM-ABC transporter signature motif; other site
216595022359	L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288
216595022360	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
216595022361	Walker A/P-loop; other site
216595022362	ATP binding site [chemical binding]; other site
216595022363	Q-loop/lid; other site
216595022364	ABC transporter signature motif; other site
216595022365	Walker B; other site
216595022366	D-loop; other site
216595022367	H-loop/switch region; other site
216595022368	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
216595022370	PS00213 Lipocalin signature.
216595022371	PS00211 ABC transporters family signature.
216595022373	PS00211 ABC transporters family signature.
216595022374	PS00017 ATP/GTP-binding site motif A (P-loop).
216595022375	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
216595022376	Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540
216595022377	ligand binding site [chemical binding]; other site
216595022379	short chain dehydrogenase; Provisional; Region: PRK07063
216595022380	classical (c) SDRs; Region: SDR_c; cd05233
216595022381	NAD(P) binding site [chemical binding]; other site
216595022382	active site
216595022384	PS00061 Short-chain dehydrogenases/reductases family signature.
216595022385	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
216595022386	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216595022387	Coenzyme A binding pocket [chemical binding]; other site
216595022389	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
216595022390	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
216595022391	substrate binding site [chemical binding]; other site
216595022392	ATP binding site [chemical binding]; other site
216595022394	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
216595022395	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
216595022396	Na binding site [ion binding]; other site
216595022398	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
216595022400	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
216595022401	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595022402	DNA-binding site [nucleotide binding]; DNA binding site
216595022403	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
216595022406	PS00043 Bacterial regulatory proteins, gntR family signature.
216595022407	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816
216595022408	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
216595022410	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595022411	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
216595022412	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216595022413	FeS/SAM binding site; other site
216595022414	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
216595022417	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
216595022418	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216595022421	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
216595022422	active site
216595022424	PS01091 Uncharacterized protein family UPF0006 signature 3.
216595022425	PS01137 Uncharacterized protein family UPF0006 signature 1.
216595022426	DNA polymerase III subunit delta'; Validated; Region: PRK05707
216595022427	DNA polymerase III subunit delta'; Validated; Region: PRK08485
216595022428	thymidylate kinase; Validated; Region: tmk; PRK00698
216595022429	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
216595022430	TMP-binding site; other site
216595022431	ATP-binding site [chemical binding]; other site
216595022433	PS01331 Thymidylate kinase signature.
216595022434	PS00017 ATP/GTP-binding site motif A (P-loop).
216595022435	YceG-like family; Region: YceG; pfam02618
216595022436	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
216595022437	dimerization interface [polypeptide binding]; other site
216595022439	1 probable transmembrane helix predicted for PFLU4701 by TMHMM2.0 at aa 5-25
216595022440	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
216595022441	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
216595022442	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595022443	catalytic residue [active]
216595022445	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
216595022446	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
216595022447	dimer interface [polypeptide binding]; other site
216595022448	active site
216595022451	PS00606 Beta-ketoacyl synthases active site.
216595022452	acyl carrier protein; Provisional; Region: acpP; PRK00982
216595022453	PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature.
216595022455	PS00012 Phosphopantetheine attachment site.
216595022456	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
216595022457	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
216595022458	NAD(P) binding site [chemical binding]; other site
216595022459	homotetramer interface [polypeptide binding]; other site
216595022460	homodimer interface [polypeptide binding]; other site
216595022461	active site
216595022463	PS00061 Short-chain dehydrogenases/reductases family signature.
216595022464	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
216595022465	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
216595022467	putative phosphate acyltransferase; Provisional; Region: PRK05331
216595022469	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
216595022471	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
216595022473	Maf-like protein; Region: Maf; pfam02545
216595022474	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
216595022475	active site
216595022476	dimer interface [polypeptide binding]; other site
216595022478	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
216595022479	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
216595022480	tandem repeat interface [polypeptide binding]; other site
216595022481	oligomer interface [polypeptide binding]; other site
216595022482	active site residues [active]
216595022484	1 probable transmembrane helix predicted for PFLU4711 by TMHMM2.0 at aa 39-61
216595022485	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
216595022486	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216595022487	motif II; other site
216595022489	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
216595022490	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
216595022491	RNA binding surface [nucleotide binding]; other site
216595022492	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
216595022493	active site
216595022495	PS01129 Rlu family of pseudouridine synthase signature.
216595022497	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
216595022498	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
216595022499	homodimer interface [polypeptide binding]; other site
216595022500	oligonucleotide binding site [chemical binding]; other site
216595022502	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
216595022503	Ligand binding site; other site
216595022504	metal-binding site
216595022505	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
216595022506	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
216595022507	XdhC Rossmann domain; Region: XdhC_C; pfam13478
216595022509	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
216595022510	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
216595022512	PS00714 Sodium:dicarboxylate symporter family signature 2.
216595022513	PS00713 Sodium:dicarboxylate symporter family signature 1.
216595022514	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
216595022515	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
216595022516	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595022518	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
216595022519	PhoQ Sensor; Region: PhoQ_Sensor; pfam08918
216595022520	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
216595022521	dimer interface [polypeptide binding]; other site
216595022522	phosphorylation site [posttranslational modification]
216595022523	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595022524	ATP binding site [chemical binding]; other site
216595022525	G-X-G motif; other site
216595022529	DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816
216595022530	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595022531	active site
216595022532	phosphorylation site [posttranslational modification]
216595022533	intermolecular recognition site; other site
216595022534	dimerization interface [polypeptide binding]; other site
216595022535	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216595022536	DNA binding site [nucleotide binding]
216595022539	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
216595022540	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
216595022542	sensor protein RstB; Provisional; Region: PRK10604
216595022543	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595022544	dimerization interface [polypeptide binding]; other site
216595022545	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595022546	dimer interface [polypeptide binding]; other site
216595022547	phosphorylation site [posttranslational modification]
216595022548	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595022549	ATP binding site [chemical binding]; other site
216595022550	Mg2+ binding site [ion binding]; other site
216595022551	G-X-G motif; other site
216595022553	PS00017 ATP/GTP-binding site motif A (P-loop).
216595022556	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
216595022557	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595022558	active site
216595022559	phosphorylation site [posttranslational modification]
216595022560	intermolecular recognition site; other site
216595022561	dimerization interface [polypeptide binding]; other site
216595022562	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216595022563	DNA binding site [nucleotide binding]
216595022566	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
216595022567	ATP cone domain; Region: ATP-cone; pfam03477
216595022568	ATP cone domain; Region: ATP-cone; pfam03477
216595022569	Class I ribonucleotide reductase; Region: RNR_I; cd01679
216595022570	active site
216595022571	dimer interface [polypeptide binding]; other site
216595022572	catalytic residues [active]
216595022573	effector binding site; other site
216595022574	R2 peptide binding site; other site
216595022578	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
216595022579	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
216595022580	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
216595022581	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
216595022585	PS00588 Flagella basal body rod proteins signature.
216595022586	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
216595022587	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
216595022588	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
216595022590	PS00012 Phosphopantetheine attachment site.
216595022591	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
216595022592	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
216595022593	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
216595022596	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
216595022597	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
216595022599	PS00588 Flagella basal body rod proteins signature.
216595022600	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
216595022601	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
216595022602	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595022605	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
216595022606	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
216595022607	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595022608	active site
216595022609	phosphorylation site [posttranslational modification]
216595022610	intermolecular recognition site; other site
216595022611	dimerization interface [polypeptide binding]; other site
216595022614	PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature.
216595022615	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018
216595022616	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
216595022618	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
216595022620	FlgN protein; Region: FlgN; pfam05130
216595022622	Flagellar regulator YcgR; Region: YcgR; pfam07317
216595022623	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
216595022624	PilZ domain; Region: PilZ; pfam07238
216595022626	putative MFS family transporter protein; Provisional; Region: PRK03633
216595022627	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595022628	putative substrate translocation pore; other site
216595022630	2 probable transmembrane helices predicted for PFLU4742 by TMHMM2.0 at aa 5-22 and 27-49
216595022631	Arc-like DNA binding domain; Region: Arc; pfam03869
216595022633	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
216595022634	MgtE intracellular N domain; Region: MgtE_N; smart00924
216595022635	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
216595022636	Divalent cation transporter; Region: MgtE; pfam01769
216595022640	carbon storage regulator; Provisional; Region: PRK01712
216595022642	aspartate kinase; Reviewed; Region: PRK06635
216595022643	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
216595022644	putative nucleotide binding site [chemical binding]; other site
216595022645	putative catalytic residues [active]
216595022646	putative Mg ion binding site [ion binding]; other site
216595022647	putative aspartate binding site [chemical binding]; other site
216595022648	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
216595022649	putative allosteric regulatory site; other site
216595022650	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
216595022651	putative allosteric regulatory residue; other site
216595022655	PS00324 Aspartokinase signature.
216595022656	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
216595022657	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
216595022658	motif 1; other site
216595022659	active site
216595022660	motif 2; other site
216595022661	motif 3; other site
216595022662	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
216595022666	PS00017 ATP/GTP-binding site motif A (P-loop).
216595022667	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
216595022668	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
216595022669	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
216595022670	tetramer interface [polypeptide binding]; other site
216595022671	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595022672	catalytic residue [active]
216595022674	ggaaccnnnnnnnnnnnnnnnnccacnna
216595022675	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-II; Region: Lumazine_synthase-II; cd09208
216595022676	active site
216595022677	homopentamer interface [polypeptide binding]; other site
216595022678	dimer interface [polypeptide binding]; other site
216595022680	Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855
216595022681	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
216595022682	putative active site [active]
216595022683	Zn binding site [ion binding]; other site
216595022685	succinylarginine dihydrolase; Provisional; Region: PRK13281
216595022687	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
216595022688	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
216595022689	NAD(P) binding site [chemical binding]; other site
216595022690	catalytic residues [active]
216595022692	PS00070 Aldehyde dehydrogenases cysteine active site.
216595022693	PS00687 Aldehyde dehydrogenases glutamic acid active site.
216595022694	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
216595022695	arginine N-succinyltransferase; Region: arg_catab_AstA; TIGR03244
216595022697	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
216595022698	Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440
216595022700	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
216595022701	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
216595022702	inhibitor-cofactor binding pocket; inhibition site
216595022703	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595022704	catalytic residue [active]
216595022706	PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site.
216595022707	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
216595022708	Leucine rich repeat; Region: LRR_8; pfam13855
216595022709	Substrate binding site [chemical binding]; other site
216595022710	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
216595022711	Leucine-rich repeats; other site
216595022712	Substrate binding site [chemical binding]; other site
216595022713	Leucine rich repeat; Region: LRR_8; pfam13855
216595022721	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
216595022722	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
216595022723	conserved cys residue [active]
216595022724	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595022725	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595022727	PS00041 Bacterial regulatory proteins, araC family signature.
216595022729	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
216595022730	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
216595022731	Walker A/P-loop; other site
216595022732	ATP binding site [chemical binding]; other site
216595022733	Q-loop/lid; other site
216595022734	ABC transporter signature motif; other site
216595022735	Walker B; other site
216595022736	D-loop; other site
216595022737	H-loop/switch region; other site
216595022739	PS00211 ABC transporters family signature.
216595022740	PS00017 ATP/GTP-binding site motif A (P-loop).
216595022741	Predicted deacylase [General function prediction only]; Region: COG3608
216595022742	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
216595022743	active site
216595022744	Zn binding site [ion binding]; other site
216595022746	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595022747	dimer interface [polypeptide binding]; other site
216595022748	conserved gate region; other site
216595022749	putative PBP binding loops; other site
216595022750	ABC-ATPase subunit interface; other site
216595022752	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595022753	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
216595022754	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595022755	dimer interface [polypeptide binding]; other site
216595022756	conserved gate region; other site
216595022757	putative PBP binding loops; other site
216595022758	ABC-ATPase subunit interface; other site
216595022760	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595022761	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
216595022762	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595022763	substrate binding pocket [chemical binding]; other site
216595022764	membrane-bound complex binding site; other site
216595022765	hinge residues; other site
216595022768	acetyl-CoA synthetase; Provisional; Region: PRK00174
216595022769	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
216595022770	active site
216595022771	CoA binding site [chemical binding]; other site
216595022772	acyl-activating enzyme (AAE) consensus motif; other site
216595022773	AMP binding site [chemical binding]; other site
216595022774	acetate binding site [chemical binding]; other site
216595022776	PS00455 Putative AMP-binding domain signature.
216595022777	PFI-10
216595022778	Protein of unknown function (DUF2790); Region: DUF2790; pfam10976
216595022779	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
216595022780	dimer interface [polypeptide binding]; other site
216595022781	putative radical transfer pathway; other site
216595022782	diiron center [ion binding]; other site
216595022783	tyrosyl radical; other site
216595022785	AAA ATPase domain; Region: AAA_15; pfam13175
216595022786	P-loop containing region of AAA domain; Region: AAA_29; cl17516
216595022787	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
216595022788	Q-loop/lid; other site
216595022789	ABC transporter signature motif; other site
216595022790	Walker B; other site
216595022791	D-loop; other site
216595022792	H-loop/switch region; other site
216595022793	PS00017 ATP/GTP-binding site motif A (P-loop).
216595022795	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
216595022796	active site
216595022798	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
216595022799	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
216595022800	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
216595022801	oligomeric interface; other site
216595022802	putative active site [active]
216595022803	homodimer interface [polypeptide binding]; other site
216595022806	5 probable transmembrane helices predicted for PFLU4775 by TMHMM2.0 at aa 4-26, 33-52, 58-80, 93-115 and 119-141
216595022808	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216595022809	salt bridge; other site
216595022810	non-specific DNA binding site [nucleotide binding]; other site
216595022811	sequence-specific DNA binding site [nucleotide binding]; other site
216595022812	amidase; Provisional; Region: PRK08137
216595022813	Amidase; Region: Amidase; cl11426
216595022815	PS00017 ATP/GTP-binding site motif A (P-loop).
216595022816	PS00217 Sugar transport proteins signature 2.
216595022817	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
216595022818	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
216595022819	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216595022820	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
216595022821	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
216595022823	PS01081 Bacterial regulatory proteins, tetR family signature.
216595022824	diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245
216595022825	MASE2 domain; Region: MASE2; pfam05230
216595022826	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216595022827	metal binding site [ion binding]; metal-binding site
216595022828	active site
216595022829	I-site; other site
216595022831	4 probable transmembrane helices predicted for PFLU4782 by TMHMM2.0 at aa 50-72, 112-134, 147-169 and 179-201
216595022833	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595022834	PAS domain; Region: PAS_9; pfam13426
216595022835	putative active site [active]
216595022836	heme pocket [chemical binding]; other site
216595022837	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595022838	PAS domain; Region: PAS_9; pfam13426
216595022839	putative active site [active]
216595022840	heme pocket [chemical binding]; other site
216595022841	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595022842	dimer interface [polypeptide binding]; other site
216595022843	putative CheW interface [polypeptide binding]; other site
216595022847	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
216595022849	2 probable transmembrane helices predicted for PFLU4784 by TMHMM2.0 at aa 42-64 and 74-96
216595022850	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595022851	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595022852	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
216595022853	dimerization interface [polypeptide binding]; other site
216595022856	hypothetical protein; Validated; Region: PRK06186
216595022857	conserved cys residue [active]
216595022859	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
216595022861	Protein of unknown function (DUF2025); Region: DUF2025; pfam09634
216595022862	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
216595022863	Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601
216595022864	active site
216595022865	catalytic site [active]
216595022866	metal binding site [ion binding]; metal-binding site
216595022868	PS00017 ATP/GTP-binding site motif A (P-loop).
216595022869	Predicted membrane protein [Function unknown]; Region: COG3212
216595022870	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
216595022872	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
216595022873	GAF domain; Region: GAF; cl17456
216595022874	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
216595022875	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595022876	dimer interface [polypeptide binding]; other site
216595022877	phosphorylation site [posttranslational modification]
216595022878	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595022879	ATP binding site [chemical binding]; other site
216595022880	Mg2+ binding site [ion binding]; other site
216595022881	G-X-G motif; other site
216595022885	HAMP domain; Region: HAMP; pfam00672
216595022886	dimerization interface [polypeptide binding]; other site
216595022887	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
216595022888	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595022889	dimer interface [polypeptide binding]; other site
216595022890	putative CheW interface [polypeptide binding]; other site
216595022893	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
216595022894	Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834
216595022895	Cl binding site [ion binding]; other site
216595022896	oligomer interface [polypeptide binding]; other site
216595022898	2 probable transmembrane helices predicted for PFLU4793 by TMHMM2.0 at aa 278-300 and 315-334
216595022899	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
216595022900	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
216595022901	10 probable transmembrane helices predicted for PFLU4794 by TMHMM2.0 at aa 27-49, 62-84, 104-126, 146-168, 175-192, 207-229, 249-266, 276-293, 420-439 and 512-534
216595022903	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
216595022905	PS00095 C-5 cytosine-specific DNA methylases C-terminal signature.
216595022906	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
216595022907	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
216595022909	uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_2; cd11664
216595022910	putative active site [active]
216595022912	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595022913	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595022914	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
216595022915	putative substrate binding pocket [chemical binding]; other site
216595022916	dimerization interface [polypeptide binding]; other site
216595022919	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595022920	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595022921	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
216595022922	putative effector binding pocket; other site
216595022923	putative dimerization interface [polypeptide binding]; other site
216595022926	PS00044 Bacterial regulatory proteins, lysR family signature.
216595022927	short chain dehydrogenase; Provisional; Region: PRK12939
216595022928	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216595022929	NAD(P) binding site [chemical binding]; other site
216595022930	active site
216595022932	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595022933	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595022934	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
216595022935	dimerization interface [polypeptide binding]; other site
216595022937	PS00017 ATP/GTP-binding site motif A (P-loop).
216595022939	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
216595022940	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
216595022944	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896
216595022945	putative hydrophobic ligand binding site [chemical binding]; other site
216595022947	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
216595022949	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
216595022950	SnoaL-like domain; Region: SnoaL_3; pfam13474
216595022951	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
216595022952	PS00430 TonB-dependent receptor proteins signature 1.
216595022954	low G+C content region 48.38%
216595022955	PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025
216595022957	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
216595022959	aminotransferase; Validated; Region: PRK08175
216595022960	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216595022961	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595022962	homodimer interface [polypeptide binding]; other site
216595022963	catalytic residue [active]
216595022965	fructuronate transporter; Provisional; Region: PRK10034; cl15264
216595022966	GntP family permease; Region: GntP_permease; pfam02447
216595022968	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
216595022969	AAA domain; Region: AAA_33; pfam13671
216595022970	ATP-binding site [chemical binding]; other site
216595022971	Gluconate-6-phosphate binding site [chemical binding]; other site
216595022972	PS00017 ATP/GTP-binding site motif A (P-loop).
216595022973	Transcriptional regulators [Transcription]; Region: PurR; COG1609
216595022974	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
216595022975	DNA binding site [nucleotide binding]
216595022976	domain linker motif; other site
216595022977	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
216595022978	putative ligand binding site [chemical binding]; other site
216595022979	putative dimerization interface [polypeptide binding]; other site
216595022981	PS00356 Bacterial regulatory proteins, lacI family signature.
216595022983	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
216595022984	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
216595022985	putative C-terminal domain interface [polypeptide binding]; other site
216595022986	putative GSH binding site (G-site) [chemical binding]; other site
216595022987	putative dimer interface [polypeptide binding]; other site
216595022988	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
216595022989	putative N-terminal domain interface [polypeptide binding]; other site
216595022990	putative dimer interface [polypeptide binding]; other site
216595022991	putative substrate binding pocket (H-site) [chemical binding]; other site
216595022994	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
216595022995	extended (e) SDRs; Region: SDR_e; cd08946
216595022996	NAD(P) binding site [chemical binding]; other site
216595022997	active site
216595022998	PS00017 ATP/GTP-binding site motif A (P-loop).
216595023000	benzoate transport; Region: 2A0115; TIGR00895
216595023001	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595023002	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595023003	12 probable transmembrane helices predicted for PFLU4817 by TMHMM2.0 at aa 25-47, 78-100, 107-129, 133-155, 167-189, 199-216, 286-308, 318-340, 347-364, 368-390, 407-429 and 434-456
216595023005	PS00216 Sugar transport proteins signature 1.
216595023006	PS00217 Sugar transport proteins signature 2.
216595023007	PS00225 Crystallins beta and gamma 'Greek key' motif signature.
216595023008	Pyruvate dehydrogenase E1 component subunit alpha; Region: PLN02269
216595023009	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595023010	PAS domain; Region: PAS_9; pfam13426
216595023011	putative active site [active]
216595023012	heme pocket [chemical binding]; other site
216595023013	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595023014	PAS domain; Region: PAS_9; pfam13426
216595023015	putative active site [active]
216595023016	heme pocket [chemical binding]; other site
216595023017	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595023018	dimer interface [polypeptide binding]; other site
216595023019	putative CheW interface [polypeptide binding]; other site
216595023023	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595023024	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595023025	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
216595023026	dimerization interface [polypeptide binding]; other site
216595023029	PS00044 Bacterial regulatory proteins, lysR family signature.
216595023030	glutathionine S-transferase; Provisional; Region: PRK10542
216595023031	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
216595023032	C-terminal domain interface [polypeptide binding]; other site
216595023033	GSH binding site (G-site) [chemical binding]; other site
216595023034	dimer interface [polypeptide binding]; other site
216595023035	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
216595023036	dimer interface [polypeptide binding]; other site
216595023037	N-terminal domain interface [polypeptide binding]; other site
216595023038	substrate binding pocket (H-site) [chemical binding]; other site
216595023041	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216595023042	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
216595023043	Coenzyme A binding pocket [chemical binding]; other site
216595023045	Methyltransferase domain; Region: Methyltransf_23; pfam13489
216595023046	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595023047	S-adenosylmethionine binding site [chemical binding]; other site
216595023049	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
216595023050	active site
216595023051	catalytic residues [active]
216595023052	metal binding site [ion binding]; metal-binding site
216595023054	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
216595023056	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677
216595023057	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
216595023058	acyl-activating enzyme (AAE) consensus motif; other site
216595023059	putative AMP binding site [chemical binding]; other site
216595023060	putative active site [active]
216595023061	putative CoA binding site [chemical binding]; other site
216595023063	PS00455 Putative AMP-binding domain signature.
216595023064	PS00017 ATP/GTP-binding site motif A (P-loop).
216595023065	long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12492
216595023066	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
216595023067	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
216595023068	acyl-activating enzyme (AAE) consensus motif; other site
216595023069	putative AMP binding site [chemical binding]; other site
216595023070	putative active site [active]
216595023071	putative CoA binding site [chemical binding]; other site
216595023073	PS00455 Putative AMP-binding domain signature.
216595023074	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
216595023075	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
216595023076	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
216595023078	PS00120 Lipases, serine active site.
216595023079	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
216595023080	dimer interaction site [polypeptide binding]; other site
216595023081	substrate-binding tunnel; other site
216595023082	active site
216595023083	catalytic site [active]
216595023084	substrate binding site [chemical binding]; other site
216595023086	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595023087	Domain of unknown function (DUF2383); Region: DUF2383; cl17556
216595023088	Protein of unknown function (DUF3820); Region: DUF3820; pfam12843
216595023089	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
216595023090	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
216595023091	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
216595023092	catalytic residue [active]
216595023094	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
216595023095	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
216595023096	active site
216595023097	intersubunit interface [polypeptide binding]; other site
216595023098	catalytic residue [active]
216595023100	PS00160 KDPG and KHG aldolases Schiff-base forming residue.
216595023101	PS00159 KDPG and KHG aldolases active site.
216595023102	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
216595023103	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
216595023104	putative active site [active]
216595023105	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
216595023106	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
216595023107	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
216595023110	PS00069 Glucose-6-phosphate dehydrogenase active site.
216595023111	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
216595023112	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
216595023113	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
216595023114	putative active site [active]
216595023117	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
216595023118	active site
216595023119	phosphate binding residues; other site
216595023120	catalytic residues [active]
216595023122	Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659
216595023124	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
216595023125	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
216595023126	Walker A/P-loop; other site
216595023127	ATP binding site [chemical binding]; other site
216595023128	Q-loop/lid; other site
216595023129	ABC transporter signature motif; other site
216595023130	Walker B; other site
216595023131	D-loop; other site
216595023132	H-loop/switch region; other site
216595023133	TOBE domain; Region: TOBE_2; pfam08402
216595023136	PS00211 ABC transporters family signature.
216595023137	PS00017 ATP/GTP-binding site motif A (P-loop).
216595023138	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
216595023139	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595023140	dimer interface [polypeptide binding]; other site
216595023141	conserved gate region; other site
216595023142	putative PBP binding loops; other site
216595023143	ABC-ATPase subunit interface; other site
216595023145	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595023146	dimer interface [polypeptide binding]; other site
216595023147	conserved gate region; other site
216595023148	putative PBP binding loops; other site
216595023149	ABC-ATPase subunit interface; other site
216595023151	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595023153	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
216595023154	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
216595023156	N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221
216595023157	putative active cleft [active]
216595023159	6 probable transmembrane helices predicted for PFLU4849 by TMHMM2.0 at aa 13-35, 40-62, 74-93, 108-130, 135-152 and 187-209
216595023160	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
216595023161	1 probable transmembrane helix predicted for PFLU4850 by TMHMM2.0 at aa 48-70
216595023162	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
216595023163	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216595023164	NAD(P) binding site [chemical binding]; other site
216595023165	active site
216595023167	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
216595023168	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595023169	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
216595023170	dimerization interface [polypeptide binding]; other site
216595023173	PS00044 Bacterial regulatory proteins, lysR family signature.
216595023174	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602
216595023175	ACT domain; Region: ACT_3; pfam10000
216595023176	Family description; Region: ACT_7; pfam13840
216595023178	Lysine efflux permease [General function prediction only]; Region: COG1279
216595023179	6 probable transmembrane helices predicted for PFLU4854 by TMHMM2.0 at aa 5-27, 40-62, 67-89, 110-132, 147-169 and 176-198
216595023181	superoxide dismutase; Provisional; Region: PRK10543
216595023182	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
216595023183	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
216595023185	PS00017 ATP/GTP-binding site motif A (P-loop).
216595023187	PS00088 Manganese and iron superoxide dismutases signature.
216595023188	PS00017 ATP/GTP-binding site motif A (P-loop).
216595023189	ggaaccnnnnnnnnnnnnnnnnccacnna
216595023190	biofilm formation regulator HmsP; Provisional; Region: PRK11829
216595023191	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216595023192	metal binding site [ion binding]; metal-binding site
216595023193	active site
216595023194	I-site; other site
216595023195	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
216595023196	2 probable transmembrane helices predicted for PFLU4858 by TMHMM2.0 at aa 13-35 and 157-179
216595023199	PS00017 ATP/GTP-binding site motif A (P-loop).
216595023200	Imelysin; Region: Peptidase_M75; cl09159
216595023201	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
216595023202	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
216595023203	10 probable transmembrane helices predicted for PFLU4861 by TMHMM2.0 at aa 12-34, 44-61, 73-95, 138-160, 181-203, 238-260, 273-295, 333-355, 395-417 and 457-479
216595023205	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
216595023206	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
216595023207	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595023209	Protein of unknown function (DUF962); Region: DUF962; cl01879
216595023210	2 probable transmembrane helices predicted for PFLU4863 by TMHMM2.0 at aa 29-46 and 50-72
216595023211	major facilitator superfamily transporter; Provisional; Region: PRK05122
216595023212	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
216595023213	putative substrate translocation pore; other site
216595023214	12 probable transmembrane helices predicted for PFLU4866 by TMHMM2.0 at aa 13-35, 45-67, 80-102, 112-134, 146-168, 172-194, 215-237, 248-267, 274-296, 306-328, 337-359 and 364-386
216595023216	hypothetical protein; Provisional; Region: PRK09256
216595023217	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
216595023219	PS00745 Prokaryotic-type class I peptide chain release factors signature.
216595023220	PS00228 Tubulin-beta mRNA autoregulation signal.
216595023221	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
216595023222	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
216595023223	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
216595023224	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
216595023229	aromatic amino acid transporter; Provisional; Region: PRK10238
216595023231	PS00218 Amino acid permeases signature.
216595023232	low G+C region (42.15%)
216595023233	Helix-turn-helix domain; Region: HTH_28; pfam13518
216595023234	Winged helix-turn helix; Region: HTH_29; pfam13551
216595023235	Homeodomain-like domain; Region: HTH_32; pfam13565
216595023236	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
216595023237	Integrase core domain; Region: rve; pfam00665
216595023238	Integrase core domain; Region: rve_3; pfam13683
216595023240	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
216595023241	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
216595023242	RNA binding surface [nucleotide binding]; other site
216595023243	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
216595023244	probable active site [active]
216595023246	PS01149 Rsu family of pseudouridine synthase signature.
216595023248	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
216595023250	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
216595023252	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
216595023254	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
216595023256	PS01147 SUA5/yciO/yrdC family signature.
216595023257	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
216595023258	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
216595023259	active site
216595023260	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
216595023262	intracellular septation protein A; Reviewed; Region: PRK00259
216595023264	6 probable transmembrane helices predicted for PFLU4881 by TMHMM2.0 at aa 7-29, 44-66, 79-96, 106-128, 148-167 and 177-196
216595023265	YciI-like protein; Reviewed; Region: PRK11370
216595023267	PsiA protein; Region: PsiA; cl11646
216595023268	1 probable transmembrane helix predicted for PFLU4883 by TMHMM2.0 at aa 105-127
216595023269	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
216595023270	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595023271	active site
216595023272	phosphorylation site [posttranslational modification]
216595023273	intermolecular recognition site; other site
216595023274	dimerization interface [polypeptide binding]; other site
216595023275	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216595023276	DNA binding site [nucleotide binding]
216595023280	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
216595023281	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
216595023282	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595023283	ATP binding site [chemical binding]; other site
216595023284	Mg2+ binding site [ion binding]; other site
216595023285	G-X-G motif; other site
216595023286	2 probable transmembrane helices predicted for PFLU4886 by TMHMM2.0 at aa 4-26 and 152-174
216595023290	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
216595023291	CoA-transferase family III; Region: CoA_transf_3; pfam02515
216595023293	AlkA N-terminal domain; Region: AlkA_N; pfam06029
216595023294	3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308
216595023295	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
216595023296	minor groove reading motif; other site
216595023297	helix-hairpin-helix signature motif; other site
216595023298	substrate binding pocket [chemical binding]; other site
216595023299	active site
216595023302	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
216595023304	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
216595023305	13 probable transmembrane helices predicted for PFLU4890 by TMHMM2.0 at aa 20-40, 53-75, 85-107, 109-131, 136-155, 162-184, 211-233, 246-268, 292-314, 342-364, 369-391, 411-433 and 463-485
216595023307	arginine deiminase; Provisional; Region: PRK01388
216595023309	PS00687 Aldehyde dehydrogenases glutamic acid active site.
216595023310	ornithine carbamoyltransferase; Validated; Region: PRK02102
216595023311	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
216595023312	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
216595023314	PS00097 Aspartate and ornithine carbamoyltransferases signature.
216595023316	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
216595023317	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
216595023318	putative substrate binding site [chemical binding]; other site
216595023319	nucleotide binding site [chemical binding]; other site
216595023320	nucleotide binding site [chemical binding]; other site
216595023321	homodimer interface [polypeptide binding]; other site
216595023323	Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283
216595023324	N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877
216595023325	putative aromatic amino acid binding site; other site
216595023326	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595023327	putative active site [active]
216595023328	heme pocket [chemical binding]; other site
216595023329	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595023330	Walker A motif; other site
216595023331	ATP binding site [chemical binding]; other site
216595023332	Walker B motif; other site
216595023333	arginine finger; other site
216595023337	PS00675 Sigma-54 interaction domain ATP-binding region A signature.
216595023338	PS00688 Sigma-54 interaction domain C-terminal part signature.
216595023339	glycine cleavage system protein H; Provisional; Region: PRK13380
216595023340	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
216595023341	lipoyl attachment site [posttranslational modification]; other site
216595023343	glycine dehydrogenase; Provisional; Region: PRK05367
216595023344	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
216595023345	tetramer interface [polypeptide binding]; other site
216595023346	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595023347	catalytic residue [active]
216595023348	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
216595023349	tetramer interface [polypeptide binding]; other site
216595023350	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595023351	catalytic residue [active]
216595023353	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
216595023354	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
216595023355	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
216595023358	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
216595023359	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
216595023362	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
216595023363	DNA-binding site [nucleotide binding]; DNA binding site
216595023364	RNA-binding motif; other site
216595023366	PS00352 'Cold-shock' DNA-binding domain signature.
216595023367	RDD family; Region: RDD; pfam06271
216595023369	3 probable transmembrane helices predicted for PFLU4901 by TMHMM2.0 at aa 25-47, 68-90 and 116-138
216595023370	quinolinate synthetase; Provisional; Region: PRK09375
216595023372	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
216595023374	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
216595023375	Ligand Binding Site [chemical binding]; other site
216595023377	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349
216595023378	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216595023379	FeS/SAM binding site; other site
216595023381	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
216595023382	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
216595023383	binding surface
216595023384	TPR motif; other site
216595023385	1 probable transmembrane helix predicted for PFLU4906 by TMHMM2.0 at aa 7-24
216595023386	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
216595023387	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
216595023388	ligand binding site [chemical binding]; other site
216595023390	PS01068 OmpA-like domain.
216595023391	PS00697 ATP-dependent DNA ligase AMP-binding site.
216595023392	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595023393	translocation protein TolB; Provisional; Region: tolB; PRK00178
216595023394	TolB amino-terminal domain; Region: TolB_N; pfam04052
216595023395	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
216595023396	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
216595023397	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
216595023404	TolA protein; Region: tolA_full; TIGR02794
216595023405	TolA protein; Region: tolA_full; TIGR02794
216595023406	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
216595023408	1 probable transmembrane helix predicted for PFLU4909 by TMHMM2.0 at aa 13-35
216595023409	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
216595023410	TolR protein; Region: tolR; TIGR02801
216595023412	1 probable transmembrane helix predicted for PFLU4910 by TMHMM2.0 at aa 19-41
216595023413	TolQ protein; Region: tolQ; TIGR02796
216595023415	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
216595023416	active site
216595023418	PS00036 bZIP transcription factors basic domain signature.
216595023419	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
216595023420	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595023421	Walker A motif; other site
216595023422	ATP binding site [chemical binding]; other site
216595023423	Walker B motif; other site
216595023424	arginine finger; other site
216595023425	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
216595023428	PS00017 ATP/GTP-binding site motif A (P-loop).
216595023430	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
216595023431	RuvA N terminal domain; Region: RuvA_N; pfam01330
216595023432	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
216595023433	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
216595023437	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
216595023438	active site
216595023439	putative DNA-binding cleft [nucleotide binding]; other site
216595023440	dimer interface [polypeptide binding]; other site
216595023442	PS01321 Crossover junction endodeoxyribonuclease ruvC signature.
216595023443	hypothetical protein; Validated; Region: PRK00110
216595023445	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
216595023446	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
216595023447	dimer interface [polypeptide binding]; other site
216595023448	anticodon binding site; other site
216595023449	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
216595023450	homodimer interface [polypeptide binding]; other site
216595023451	motif 1; other site
216595023452	active site
216595023453	motif 2; other site
216595023454	GAD domain; Region: GAD; pfam02938
216595023455	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
216595023456	active site
216595023457	motif 3; other site
216595023459	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
216595023461	PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1.
216595023463	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
216595023464	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
216595023465	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
216595023466	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
216595023467	dimerization interface [polypeptide binding]; other site
216595023468	DPS ferroxidase diiron center [ion binding]; other site
216595023469	ion pore; other site
216595023471	PS00819 Dps protein family signature 2.
216595023472	PS00818 Dps protein family signature 1.
216595023473	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
216595023474	DNA-binding site [nucleotide binding]; DNA binding site
216595023475	RNA-binding motif; other site
216595023477	PS00352 'Cold-shock' DNA-binding domain signature.
216595023478	hypothetical protein; Provisional; Region: PRK00295
216595023480	HIT domain; Region: HIT; pfam01230
216595023482	outer membrane porin, OprD family; Region: OprD; pfam03573
216595023484	mechanosensitive channel MscS; Provisional; Region: PRK10334
216595023485	Mechanosensitive ion channel; Region: MS_channel; pfam00924
216595023487	PS01246 Uncharacterized protein family UPF0003 signature.
216595023488	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
216595023489	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
216595023491	2-dehydropantoate 2-reductase; Provisional; Region: PRK05708
216595023492	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
216595023493	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
216595023496	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595023497	dimerization interface [polypeptide binding]; other site
216595023498	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
216595023499	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595023500	putative active site [active]
216595023501	heme pocket [chemical binding]; other site
216595023502	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595023503	dimer interface [polypeptide binding]; other site
216595023504	phosphorylation site [posttranslational modification]
216595023505	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595023506	ATP binding site [chemical binding]; other site
216595023507	Mg2+ binding site [ion binding]; other site
216595023508	G-X-G motif; other site
216595023509	2 probable transmembrane helices predicted for PFLU4929 by TMHMM2.0 at aa 5-27 and 142-164
216595023514	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
216595023517	hypothetical protein; Provisional; Region: PRK08999
216595023518	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
216595023519	active site
216595023520	8-oxo-dGMP binding site [chemical binding]; other site
216595023521	nudix motif; other site
216595023522	metal binding site [ion binding]; metal-binding site
216595023523	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
216595023524	thiamine phosphate binding site [chemical binding]; other site
216595023525	active site
216595023526	pyrophosphate binding site [ion binding]; other site
216595023529	PS00893 mutT domain signature.
216595023530	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
216595023531	heterotetramer interface [polypeptide binding]; other site
216595023532	active site pocket [active]
216595023533	cleavage site
216595023535	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK13103
216595023536	DEAD/DEAH box helicase; Region: DEAD; pfam00270
216595023537	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
216595023538	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
216595023539	nucleotide binding region [chemical binding]; other site
216595023540	ATP-binding site [chemical binding]; other site
216595023541	SEC-C motif; Region: SEC-C; pfam02810
216595023547	Protein of unknown function (DUF721); Region: DUF721; pfam05258
216595023548	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
216595023549	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
216595023551	PS00017 ATP/GTP-binding site motif A (P-loop).
216595023552	Cache domain; Region: Cache_1; pfam02743
216595023553	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595023554	dimerization interface [polypeptide binding]; other site
216595023555	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
216595023556	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595023557	dimer interface [polypeptide binding]; other site
216595023558	putative CheW interface [polypeptide binding]; other site
216595023559	2 probable transmembrane helices predicted for PFLU4936 by TMHMM2.0 at aa 7-29 and 279-301
216595023563	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
216595023564	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
216595023565	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
216595023566	putative active site [active]
216595023567	putative substrate binding site [chemical binding]; other site
216595023568	putative cosubstrate binding site; other site
216595023569	catalytic site [active]
216595023572	PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature.
216595023573	exonuclease I; Provisional; Region: sbcB; PRK11779
216595023574	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
216595023575	active site
216595023576	catalytic site [active]
216595023577	substrate binding site [chemical binding]; other site
216595023578	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
216595023581	RDD family; Region: RDD; pfam06271
216595023583	1 probable transmembrane helix predicted for PFLU4941 by TMHMM2.0 at aa 97-119
216595023584	PS00107 Protein kinases ATP-binding region signature.
216595023585	Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300
216595023586	6 probable transmembrane helices predicted for PFLU4942 by TMHMM2.0 at aa 104-126, 176-198, 203-225, 229-251, 271-290 and 295-317
216595023588	PS00922 Prokaryotic transglycosylases signature.
216595023589	5 probable transmembrane helices predicted for PFLU4943 by TMHMM2.0 at aa 31-53, 154-176, 206-228, 249-271 and 346-368
216595023590	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
216595023591	2 probable transmembrane helices predicted for PFLU4944 by TMHMM2.0 at aa 5-24 and 254-276
216595023592	MoxR-like ATPases [General function prediction only]; Region: COG0714
216595023593	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595023594	Walker A motif; other site
216595023595	ATP binding site [chemical binding]; other site
216595023596	Walker B motif; other site
216595023597	arginine finger; other site
216595023599	PS00017 ATP/GTP-binding site motif A (P-loop).
216595023600	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
216595023601	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
216595023602	metal ion-dependent adhesion site (MIDAS); other site
216595023603	2 probable transmembrane helices predicted for PFLU4946 by TMHMM2.0 at aa 7-29 and 34-52
216595023605	PilZ domain; Region: PilZ; pfam07238
216595023606	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
216595023607	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595023608	pyruvate kinase; Provisional; Region: PRK05826
216595023609	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
216595023610	domain interfaces; other site
216595023611	active site
216595023613	PS00110 Pyruvate kinase active site signature.
216595023615	enoyl-CoA hydratase; Provisional; Region: PRK06688
216595023616	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
216595023617	substrate binding site [chemical binding]; other site
216595023618	oxyanion hole (OAH) forming residues; other site
216595023619	trimer interface [polypeptide binding]; other site
216595023620	Tellurite resistance protein TerB; Region: TerB; cl17311
216595023622	1 probable transmembrane helix predicted for PFLU4950 by TMHMM2.0 at aa 97-119
216595023623	hypothetical protein; Provisional; Region: PRK05713
216595023624	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
216595023625	catalytic loop [active]
216595023626	iron binding site [ion binding]; other site
216595023627	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194
216595023628	FAD binding pocket [chemical binding]; other site
216595023629	FAD binding motif [chemical binding]; other site
216595023630	phosphate binding motif [ion binding]; other site
216595023631	beta-alpha-beta structure motif; other site
216595023632	NAD binding pocket [chemical binding]; other site
216595023636	putative fumarate hydratase; Provisional; Region: PRK15392
216595023637	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
216595023638	Fumarase C-terminus; Region: Fumerase_C; pfam05683
216595023641	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
216595023642	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595023643	dimer interface [polypeptide binding]; other site
216595023644	phosphorylation site [posttranslational modification]
216595023645	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595023646	ATP binding site [chemical binding]; other site
216595023647	Mg2+ binding site [ion binding]; other site
216595023648	G-X-G motif; other site
216595023649	1 probable transmembrane helix predicted for PFLU4953 by TMHMM2.0 at aa 71-90
216595023652	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
216595023653	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595023654	active site
216595023655	phosphorylation site [posttranslational modification]
216595023656	intermolecular recognition site; other site
216595023657	dimerization interface [polypeptide binding]; other site
216595023658	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595023659	Walker A motif; other site
216595023660	ATP binding site [chemical binding]; other site
216595023661	Walker B motif; other site
216595023662	arginine finger; other site
216595023663	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
216595023666	PS00675 Sigma-54 interaction domain ATP-binding region A signature.
216595023667	PS00676 Sigma-54 interaction domain ATP-binding region B signature.
216595023668	PS00688 Sigma-54 interaction domain C-terminal part signature.
216595023670	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
216595023671	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595023672	putative substrate translocation pore; other site
216595023674	11 probable transmembrane helices predicted for PFLU4955 by TMHMM2.0 at aa 64-86, 99-118, 122-144, 164-186, 196-218, 249-271, 286-308, 315-337, 341-363, 376-398 and 408-425
216595023675	PS00216 Sugar transport proteins signature 1.
216595023676	PS00217 Sugar transport proteins signature 2.
216595023677	PS00216 Sugar transport proteins signature 1.
216595023678	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705
216595023679	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
216595023680	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
216595023681	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
216595023684	PS00107 Protein kinases ATP-binding region signature.
216595023686	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
216595023687	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
216595023689	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
216595023690	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
216595023691	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595023693	PS00041 Bacterial regulatory proteins, araC family signature.
216595023695	HAMP domain; Region: HAMP; pfam00672
216595023696	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595023697	ATP binding site [chemical binding]; other site
216595023698	Mg2+ binding site [ion binding]; other site
216595023699	G-X-G motif; other site
216595023703	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
216595023704	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595023705	active site
216595023706	phosphorylation site [posttranslational modification]
216595023707	intermolecular recognition site; other site
216595023708	dimerization interface [polypeptide binding]; other site
216595023709	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216595023710	DNA binding site [nucleotide binding]
216595023713	glucokinase, proteobacterial type; Region: glk; TIGR00749
216595023714	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
216595023715	nucleotide binding site [chemical binding]; other site
216595023717	phosphogluconate dehydratase; Validated; Region: PRK09054
216595023718	6-phosphogluconate dehydratase; Region: edd; TIGR01196
216595023720	PS00887 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 2.
216595023721	PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1.
216595023722	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595023723	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
216595023724	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
216595023725	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
216595023727	PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site.
216595023729	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
216595023730	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
216595023731	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
216595023732	DNA binding residues [nucleotide binding]
216595023735	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
216595023736	FecR protein; Region: FecR; pfam04773
216595023737	PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.
216595023739	Secretin and TonB N terminus short domain; Region: STN; smart00965
216595023740	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
216595023741	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216595023742	N-terminal plug; other site
216595023743	ligand-binding site [chemical binding]; other site
216595023744	1 probable transmembrane helix predicted for PFLU4968 by TMHMM2.0 at aa 12-34
216595023748	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
216595023749	heme binding pocket [chemical binding]; other site
216595023750	heme ligand [chemical binding]; other site
216595023752	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
216595023753	2 probable transmembrane helices predicted for PFLU4970 by TMHMM2.0 at aa 12-34 and 106-123
216595023755	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595023756	dimerization interface [polypeptide binding]; other site
216595023757	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
216595023758	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595023759	dimer interface [polypeptide binding]; other site
216595023760	putative CheW interface [polypeptide binding]; other site
216595023761	2 probable transmembrane helices predicted for PFLU4971 by TMHMM2.0 at aa 15-37 and 366-388
216595023766	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
216595023767	putative FMN binding site [chemical binding]; other site
216595023769	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
216595023770	Protein of unknown function (DUF1111); Region: DUF1111; pfam06537
216595023772	PS00190 Cytochrome c family heme-binding site signature.
216595023773	PS00190 Cytochrome c family heme-binding site signature.
216595023774	Imelysin; Region: Peptidase_M75; cl09159
216595023775	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3490
216595023777	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
216595023778	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
216595023779	HlyD family secretion protein; Region: HlyD_3; pfam13437
216595023780	1 probable transmembrane helix predicted for PFLU4976 by TMHMM2.0 at aa 7-29
216595023782	multidrug efflux protein; Reviewed; Region: PRK09579
216595023783	Protein export membrane protein; Region: SecD_SecF; cl14618
216595023784	Protein export membrane protein; Region: SecD_SecF; cl14618
216595023786	12 probable transmembrane helices predicted for PFLU4977 by TMHMM2.0 at aa 12-30, 333-355, 357-379, 383-405, 430-452, 467-489, 525-547, 844-866, 873-895, 900-922, 943-965 and 980-1002
216595023787	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
216595023788	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
216595023789	HlyD family secretion protein; Region: HlyD_3; pfam13437
216595023790	1 probable transmembrane helix predicted for PFLU4978 by TMHMM2.0 at aa 46-68
216595023793	multidrug efflux protein; Reviewed; Region: PRK09579
216595023794	Protein export membrane protein; Region: SecD_SecF; cl14618
216595023796	12 probable transmembrane helices predicted for PFLU4979 by TMHMM2.0 at aa 7-29, 333-355, 357-379, 383-405, 430-452, 467-489, 520-542, 843-865, 872-894, 899-921, 942-964 and 979-1001
216595023797	PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide.
216595023798	1 probable transmembrane helix predicted for PFLU4980 by TMHMM2.0 at aa 5-24
216595023799	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
216595023801	Methyltransferase domain; Region: Methyltransf_23; pfam13489
216595023802	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595023803	S-adenosylmethionine binding site [chemical binding]; other site
216595023805	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
216595023806	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595023807	dimer interface [polypeptide binding]; other site
216595023808	phosphorylation site [posttranslational modification]
216595023809	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595023810	ATP binding site [chemical binding]; other site
216595023811	Mg2+ binding site [ion binding]; other site
216595023812	G-X-G motif; other site
216595023816	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
216595023817	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595023818	active site
216595023819	phosphorylation site [posttranslational modification]
216595023820	intermolecular recognition site; other site
216595023821	dimerization interface [polypeptide binding]; other site
216595023822	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216595023823	DNA binding site [nucleotide binding]
216595023826	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
216595023827	Sulfatase; Region: Sulfatase; pfam00884
216595023828	5 probable transmembrane helices predicted for PFLU4985 by TMHMM2.0 at aa 59-81, 96-118, 131-153, 180-202 and 223-240
216595023830	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
216595023831	active site
216595023832	6 probable transmembrane helices predicted for PFLU4986 by TMHMM2.0 at aa 13-35, 71-93, 100-122, 155-172, 184-201 and 211-230
216595023834	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
216595023835	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
216595023836	ring oligomerisation interface [polypeptide binding]; other site
216595023837	ATP/Mg binding site [chemical binding]; other site
216595023838	stacking interactions; other site
216595023839	hinge regions; other site
216595023841	PS00296 Chaperonins cpn60 signature.
216595023842	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
216595023843	oligomerisation interface [polypeptide binding]; other site
216595023844	mobile loop; other site
216595023845	roof hairpin; other site
216595023847	PS00681 Chaperonins cpn10 signature.
216595023848	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
216595023850	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
216595023851	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
216595023852	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
216595023854	Protein of unknown function, DUF481; Region: DUF481; pfam04338
216595023855	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
216595023856	DNA binding site [nucleotide binding]
216595023857	active site
216595023859	muropeptide transporter; Validated; Region: ampG; cl17669
216595023860	muropeptide transporter; Validated; Region: ampG; cl17669
216595023861	14 probable transmembrane helices predicted for PFLU4993 by TMHMM2.0 at aa 20-42, 52-69, 89-108, 113-130, 151-173, 188-210, 231-253, 276-295, 315-337, 352-374, 379-401, 411-433, 446-468 and 473-495
216595023863	prolyl-tRNA synthetase; Provisional; Region: PRK09194
216595023864	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
216595023865	dimer interface [polypeptide binding]; other site
216595023866	motif 1; other site
216595023867	active site
216595023868	motif 2; other site
216595023869	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
216595023870	putative deacylase active site [active]
216595023871	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
216595023872	active site
216595023873	motif 3; other site
216595023874	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
216595023875	anticodon binding site; other site
216595023877	PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1.
216595023880	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595023881	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
216595023882	active site
216595023883	DNA polymerase IV; Validated; Region: PRK02406
216595023884	DNA binding site [nucleotide binding]
216595023886	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
216595023887	Uncharacterized conserved protein [Function unknown]; Region: COG2898
216595023888	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
216595023889	14 probable transmembrane helices predicted for PFLU4997 by TMHMM2.0 at aa 35-57, 74-96, 111-133, 154-176, 186-208, 238-260, 270-301, 314-336, 351-373, 394-416, 421-440, 447-466, 476-498 and 519-541
216595023893	Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946
216595023894	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
216595023895	1 probable transmembrane helix predicted for PFLU4998 by TMHMM2.0 at aa 5-27
216595023897	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
216595023898	DHH family; Region: DHH; pfam01368
216595023899	DHHA1 domain; Region: DHHA1; pfam02272
216595023902	YaeQ protein; Region: YaeQ; pfam07152
216595023904	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
216595023905	CoA-transferase family III; Region: CoA_transf_3; pfam02515
216595023907	conserved hypothetical protein; Region: TIGR02285
216595023908	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595023909	Protein of unknown function (DUF3509); Region: DUF3509; pfam12021
216595023910	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
216595023911	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
216595023912	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595023913	catalytic residue [active]
216595023915	PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site.
216595023916	homoserine dehydrogenase; Provisional; Region: PRK06349
216595023917	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
216595023918	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
216595023919	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
216595023922	PS01042 Homoserine dehydrogenase signature.
216595023924	PS00318 Hydroxymethylglutaryl-coenzyme A reductases signature 2.
216595023925	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
216595023926	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
216595023927	dimerization domain [polypeptide binding]; other site
216595023928	dimer interface [polypeptide binding]; other site
216595023929	catalytic residues [active]
216595023930	PS00194 Thioredoxin family active site.
216595023931	1 probable transmembrane helix predicted for PFLU5007 by TMHMM2.0 at aa 28-50
216595023932	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
216595023933	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
216595023934	active site
216595023935	Int/Topo IB signature motif; other site
216595023938	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
216595023940	PS01015 Ribosomal protein L19 signature.
216595023941	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
216595023943	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
216595023944	RimM N-terminal domain; Region: RimM; pfam01782
216595023945	PRC-barrel domain; Region: PRC; pfam05239
216595023948	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
216595023950	signal recognition particle protein; Provisional; Region: PRK10867
216595023951	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
216595023952	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
216595023953	P loop; other site
216595023954	GTP binding site [chemical binding]; other site
216595023955	Signal peptide binding domain; Region: SRP_SPB; pfam02978
216595023958	PS00300 SRP54-type proteins GTP-binding domain signature.
216595023959	PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide.
216595023960	PS00017 ATP/GTP-binding site motif A (P-loop).
216595023962	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
216595023963	8 probable transmembrane helices predicted for PFLU5014 by TMHMM2.0 at aa 4-26, 39-61, 66-88, 95-117, 132-154, 180-202, 207-229 and 242-259
216595023965	hypothetical protein; Provisional; Region: PRK11573
216595023966	Domain of unknown function DUF21; Region: DUF21; pfam01595
216595023967	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
216595023968	Transporter associated domain; Region: CorC_HlyC; smart01091
216595023969	4 probable transmembrane helices predicted for PFLU5015 by TMHMM2.0 at aa 4-26, 59-81, 86-108 and 115-137
216595023973	metabolite-proton symporter; Region: 2A0106; TIGR00883
216595023974	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595023975	putative substrate translocation pore; other site
216595023977	11 probable transmembrane helices predicted for PFLU5016 by TMHMM2.0 at aa 36-58, 68-90, 99-121, 170-192, 199-221, 254-276, 289-311, 321-340, 347-369, 379-401 and 408-430
216595023978	PS00216 Sugar transport proteins signature 1.
216595023979	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
216595023980	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216595023981	ATP-grasp domain; Region: ATP-grasp; pfam02222
216595023983	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
216595023984	Predicted Fe-S protein [General function prediction only]; Region: COG3313
216595023986	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
216595023987	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
216595023988	trimer interface [polypeptide binding]; other site
216595023989	putative metal binding site [ion binding]; other site
216595023994	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
216595023995	putative active site [active]
216595023996	putative CoA binding site [chemical binding]; other site
216595023997	nudix motif; other site
216595023998	metal binding site [ion binding]; metal-binding site
216595024000	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
216595024001	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
216595024002	nudix motif; other site
216595024004	PS00893 mutT domain signature.
216595024005	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
216595024007	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
216595024008	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595024009	DNA-binding site [nucleotide binding]; DNA binding site
216595024010	UTRA domain; Region: UTRA; pfam07702
216595024012	PS00043 Bacterial regulatory proteins, gntR family signature.
216595024014	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
216595024015	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
216595024016	active site
216595024017	dimer interface [polypeptide binding]; other site
216595024019	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
216595024020	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
216595024021	dimer interface [polypeptide binding]; other site
216595024022	active site
216595024023	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
216595024024	dimer interface [polypeptide binding]; other site
216595024025	active site
216595024028	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
216595024029	HPr interaction site; other site
216595024030	glycerol kinase (GK) interaction site [polypeptide binding]; other site
216595024031	active site
216595024032	phosphorylation site [posttranslational modification]
216595024033	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
216595024034	dimerization domain swap beta strand [polypeptide binding]; other site
216595024035	regulatory protein interface [polypeptide binding]; other site
216595024036	active site
216595024037	regulatory phosphorylation site [posttranslational modification]; other site
216595024038	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
216595024039	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
216595024040	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
216595024041	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
216595024043	PS00178 Aminoacyl-transfer RNA synthetases class-I signature.
216595024044	PS00371 PTS EIIA domains phosphorylation site signature 1.
216595024046	PS00369 PTS HPR component histidine phosphorylation site signature.
216595024050	PS00742 PEP-utilizing enzymes signature 2.
216595024051	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
216595024052	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
216595024053	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
216595024054	active site turn [active]
216595024055	phosphorylation site [posttranslational modification]
216595024056	phosphotransferase system, EIIB; Region: PTS_EIIB; pfam00367
216595024057	active site turn [active]
216595024058	phosphorylation site [posttranslational modification]
216595024059	12 probable transmembrane helices predicted for PFLU5028 by TMHMM2.0 at aa 12-30, 45-67, 72-89, 94-113, 134-156, 166-188, 195-217, 232-249, 262-280, 285-307, 314-332 and 337-359
216595024062	PS01035 PTS EIIB domains cysteine phosphorylation site signature.
216595024063	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
216595024064	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216595024065	sequence-specific DNA binding site [nucleotide binding]; other site
216595024066	salt bridge; other site
216595024067	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
216595024069	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
216595024070	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
216595024071	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
216595024072	dimerization interface [polypeptide binding]; other site
216595024073	ATP binding site [chemical binding]; other site
216595024074	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
216595024075	dimerization interface [polypeptide binding]; other site
216595024076	ATP binding site [chemical binding]; other site
216595024077	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
216595024078	putative active site [active]
216595024079	catalytic triad [active]
216595024083	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
216595024084	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595024085	substrate binding pocket [chemical binding]; other site
216595024086	membrane-bound complex binding site; other site
216595024087	hinge residues; other site
216595024088	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
216595024089	N-acetyl-D-glucosamine binding site [chemical binding]; other site
216595024090	catalytic residue [active]
216595024091	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595024094	PS00922 Prokaryotic transglycosylases signature.
216595024095	1 probable transmembrane helix predicted for PFLU5036 by TMHMM2.0 at aa 68-90
216595024096	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
216595024097	HPr interaction site; other site
216595024098	glycerol kinase (GK) interaction site [polypeptide binding]; other site
216595024099	active site
216595024100	phosphorylation site [posttranslational modification]
216595024101	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
216595024102	dimerization domain swap beta strand [polypeptide binding]; other site
216595024103	regulatory protein interface [polypeptide binding]; other site
216595024104	active site
216595024105	regulatory phosphorylation site [posttranslational modification]; other site
216595024106	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
216595024107	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
216595024108	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
216595024109	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
216595024111	PS00742 PEP-utilizing enzymes signature 2.
216595024115	PS00012 Phosphopantetheine attachment site.
216595024116	PS00369 PTS HPR component histidine phosphorylation site signature.
216595024118	PS00371 PTS EIIA domains phosphorylation site signature 1.
216595024120	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
216595024121	trimer interface; other site
216595024122	sugar binding site [chemical binding]; other site
216595024124	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
216595024125	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
216595024126	Ca binding site [ion binding]; other site
216595024127	active site
216595024128	catalytic site [active]
216595024130	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
216595024131	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
216595024132	active site turn [active]
216595024133	phosphorylation site [posttranslational modification]
216595024134	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
216595024136	PS00017 ATP/GTP-binding site motif A (P-loop).
216595024138	PS01035 PTS EIIB domains cysteine phosphorylation site signature.
216595024139	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595024140	DNA-binding site [nucleotide binding]; DNA binding site
216595024141	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
216595024142	UTRA domain; Region: UTRA; pfam07702
216595024145	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
216595024146	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216595024147	non-specific DNA binding site [nucleotide binding]; other site
216595024148	salt bridge; other site
216595024149	sequence-specific DNA binding site [nucleotide binding]; other site
216595024151	GMP synthase; Reviewed; Region: guaA; PRK00074
216595024152	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
216595024153	AMP/PPi binding site [chemical binding]; other site
216595024154	candidate oxyanion hole; other site
216595024155	catalytic triad [active]
216595024156	potential glutamine specificity residues [chemical binding]; other site
216595024157	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
216595024158	ATP Binding subdomain [chemical binding]; other site
216595024159	Ligand Binding sites [chemical binding]; other site
216595024160	Dimerization subdomain; other site
216595024164	PS00442 Glutamine amidotransferases class-I active site.
216595024165	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
216595024166	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
216595024167	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
216595024168	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
216595024169	active site
216595024171	PS00487 IMP dehydrogenase / GMP reductase signature.
216595024173	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
216595024175	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595024176	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595024177	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
216595024178	dimerization interface [polypeptide binding]; other site
216595024179	substrate binding pocket [chemical binding]; other site
216595024181	PS00044 Bacterial regulatory proteins, lysR family signature.
216595024183	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
216595024184	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
216595024185	generic binding surface II; other site
216595024186	generic binding surface I; other site
216595024189	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
216595024190	Peptidase family M23; Region: Peptidase_M23; pfam01551
216595024192	2-isopropylmalate synthase; Validated; Region: PRK03739
216595024193	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
216595024194	active site
216595024195	catalytic residues [active]
216595024196	metal binding site [ion binding]; metal-binding site
216595024197	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
216595024198	PS00815 Alpha-isopropylmalate and homocitrate synthases signature 1.
216595024200	PS00816 Alpha-isopropylmalate and homocitrate synthases signature 2.
216595024202	C-N hydrolase family amidase; Provisional; Region: PRK10438
216595024203	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
216595024204	putative active site [active]
216595024205	catalytic triad [active]
216595024206	dimer interface [polypeptide binding]; other site
216595024207	multimer interface [polypeptide binding]; other site
216595024209	methionine aminotransferase; Validated; Region: PRK09082
216595024210	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216595024211	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595024212	homodimer interface [polypeptide binding]; other site
216595024213	catalytic residue [active]
216595024215	GTP-binding protein Der; Reviewed; Region: PRK00093
216595024216	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
216595024217	G1 box; other site
216595024218	GTP/Mg2+ binding site [chemical binding]; other site
216595024219	Switch I region; other site
216595024220	G2 box; other site
216595024221	Switch II region; other site
216595024222	G3 box; other site
216595024223	G4 box; other site
216595024224	G5 box; other site
216595024225	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
216595024226	G1 box; other site
216595024227	GTP/Mg2+ binding site [chemical binding]; other site
216595024228	Switch I region; other site
216595024229	G2 box; other site
216595024230	G3 box; other site
216595024231	Switch II region; other site
216595024232	G4 box; other site
216595024233	G5 box; other site
216595024235	PS00017 ATP/GTP-binding site motif A (P-loop).
216595024237	PS00017 ATP/GTP-binding site motif A (P-loop).
216595024238	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
216595024239	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
216595024240	Trp docking motif [polypeptide binding]; other site
216595024241	active site
216595024244	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595024245	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
216595024246	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
216595024247	1 probable transmembrane helix predicted for PFLU5055 by TMHMM2.0 at aa 15-37
216595024248	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
216595024249	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
216595024250	dimer interface [polypeptide binding]; other site
216595024251	motif 1; other site
216595024252	active site
216595024253	motif 2; other site
216595024254	motif 3; other site
216595024255	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
216595024256	anticodon binding site; other site
216595024258	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
216595024260	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
216595024261	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
216595024262	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
216595024264	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
216595024265	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216595024266	non-specific DNA binding site [nucleotide binding]; other site
216595024267	salt bridge; other site
216595024268	sequence-specific DNA binding site [nucleotide binding]; other site
216595024269	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
216595024270	1 probable transmembrane helix predicted for PFLU5058 by TMHMM2.0 at aa 111-133
216595024271	PS00716 Sigma-70 factors family signature 2.
216595024273	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
216595024274	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
216595024275	binding surface
216595024276	TPR motif; other site
216595024277	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
216595024278	binding surface
216595024279	TPR motif; other site
216595024284	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595024285	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
216595024286	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216595024287	FeS/SAM binding site; other site
216595024289	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
216595024290	active site
216595024291	multimer interface [polypeptide binding]; other site
216595024293	PS00469 Nucleoside diphosphate kinases active site.
216595024294	FeS assembly protein IscX; Region: iscX_yfhJ; TIGR03412
216595024296	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
216595024297	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
216595024298	catalytic loop [active]
216595024299	iron binding site [ion binding]; other site
216595024301	chaperone protein HscA; Provisional; Region: hscA; PRK05183
216595024302	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
216595024303	nucleotide binding site [chemical binding]; other site
216595024304	putative NEF/HSP70 interaction site [polypeptide binding]; other site
216595024305	SBD interface [polypeptide binding]; other site
216595024307	PS01036 Heat shock hsp70 proteins family signature 3.
216595024308	PS00329 Heat shock hsp70 proteins family signature 2.
216595024309	PS01036 Heat shock hsp70 proteins family signature 3.
216595024310	PS00297 Heat shock hsp70 proteins family signature 1.
216595024311	co-chaperone HscB; Provisional; Region: hscB; PRK00294
216595024312	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
216595024313	HSP70 interaction site [polypeptide binding]; other site
216595024314	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
216595024317	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
216595024318	PS01152 Hypothetical hesB/yadR/yfhF family signature.
216595024320	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
216595024321	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
216595024322	trimerization site [polypeptide binding]; other site
216595024323	active site
216595024325	cysteine desulfurase; Provisional; Region: PRK14012
216595024326	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
216595024327	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
216595024328	catalytic residue [active]
216595024330	PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site.
216595024331	iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010
216595024332	Rrf2 family protein; Region: rrf2_super; TIGR00738
216595024334	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
216595024335	serine O-acetyltransferase; Region: cysE; TIGR01172
216595024336	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
216595024337	trimer interface [polypeptide binding]; other site
216595024338	active site
216595024339	substrate binding site [chemical binding]; other site
216595024340	CoA binding site [chemical binding]; other site
216595024345	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
216595024346	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
216595024348	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
216595024349	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
216595024350	active site
216595024351	dimerization interface [polypeptide binding]; other site
216595024353	PS00629 Inositol monophosphatase family signature 1.
216595024354	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595024355	PS00630 Inositol monophosphatase family signature 2.
216595024357	hypothetical protein; Provisional; Region: PRK11280
216595024359	1 probable transmembrane helix predicted for PFLU5073 by TMHMM2.0 at aa 13-35
216595024360	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
216595024361	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
216595024362	Protein export membrane protein; Region: SecD_SecF; pfam02355
216595024365	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
216595024366	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
216595024367	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
216595024368	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
216595024370	PS00132 Zinc carboxypeptidases, zinc-binding region 1 signature.
216595024371	PS00017 ATP/GTP-binding site motif A (P-loop).
216595024373	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
216595024375	1 probable transmembrane helix predicted for PFLU5076 by TMHMM2.0 at aa 20-42
216595024376	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
216595024377	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
216595024379	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
216595024380	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
216595024382	PFI-11
216595024383	integrase; Provisional; Region: PRK09692
216595024384	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
216595024385	active site
216595024386	Int/Topo IB signature motif; other site
216595024388	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
216595024390	Ion channel; Region: Ion_trans_2; pfam07885
216595024392	AAA domain; Region: AAA_21; pfam13304
216595024393	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
216595024394	Q-loop/lid; other site
216595024395	ABC transporter signature motif; other site
216595024396	Walker B; other site
216595024397	D-loop; other site
216595024398	H-loop/switch region; other site
216595024399	PS00017 ATP/GTP-binding site motif A (P-loop).
216595024400	PS00017 ATP/GTP-binding site motif A (P-loop).
216595024401	Response regulator receiver domain; Region: Response_reg; pfam00072
216595024402	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595024403	active site
216595024404	phosphorylation site [posttranslational modification]
216595024405	intermolecular recognition site; other site
216595024406	dimerization interface [polypeptide binding]; other site
216595024408	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
216595024409	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595024410	active site
216595024411	phosphorylation site [posttranslational modification]
216595024412	intermolecular recognition site; other site
216595024413	dimerization interface [polypeptide binding]; other site
216595024414	CheB methylesterase; Region: CheB_methylest; pfam01339
216595024417	chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13498
216595024418	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
216595024419	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
216595024420	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595024421	S-adenosylmethionine binding site [chemical binding]; other site
216595024424	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
216595024425	putative CheA interaction surface; other site
216595024427	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
216595024428	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595024429	dimerization interface [polypeptide binding]; other site
216595024430	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
216595024431	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595024432	dimer interface [polypeptide binding]; other site
216595024433	putative CheW interface [polypeptide binding]; other site
216595024436	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
216595024437	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
216595024438	putative binding surface; other site
216595024439	active site
216595024440	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
216595024441	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595024442	ATP binding site [chemical binding]; other site
216595024443	Mg2+ binding site [ion binding]; other site
216595024444	G-X-G motif; other site
216595024445	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
216595024448	PS00017 ATP/GTP-binding site motif A (P-loop).
216595024451	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
216595024452	anti sigma factor interaction site; other site
216595024453	regulatory phosphorylation site [posttranslational modification]; other site
216595024455	Response regulator receiver domain; Region: Response_reg; pfam00072
216595024456	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595024457	active site
216595024458	phosphorylation site [posttranslational modification]
216595024459	intermolecular recognition site; other site
216595024460	dimerization interface [polypeptide binding]; other site
216595024463	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
216595024465	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
216595024467	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
216595024468	pentamer interface [polypeptide binding]; other site
216595024469	dodecaamer interface [polypeptide binding]; other site
216595024471	Protein of unknown function (DUF3077); Region: DUF3077; pfam11275
216595024472	Low G+C content region (39.7%)
216595024473	PIN domain; Region: PIN_3; pfam13470
216595024474	PS00334 Myb DNA-binding domain repeat signature 2.
216595024475	DNA binding domain, excisionase family; Region: excise; TIGR01764
216595024477	S-type Pyocin; Region: Pyocin_S; pfam06958
216595024478	Cytotoxic; Region: Cytotoxic; pfam09000
216595024481	Cloacin immunity protein; Region: Cloacin_immun; pfam03513
216595024483	Chordopoxvirus G3 protein; Region: Chordopox_G3; cl17332
216595024484	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595024485	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
216595024486	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595024487	dimer interface [polypeptide binding]; other site
216595024488	phosphorylation site [posttranslational modification]
216595024489	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595024490	ATP binding site [chemical binding]; other site
216595024491	Mg2+ binding site [ion binding]; other site
216595024492	G-X-G motif; other site
216595024495	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
216595024496	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595024497	active site
216595024498	phosphorylation site [posttranslational modification]
216595024499	intermolecular recognition site; other site
216595024500	dimerization interface [polypeptide binding]; other site
216595024501	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216595024502	DNA binding site [nucleotide binding]
216595024505	PS00217 Sugar transport proteins signature 2.
216595024506	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
216595024507	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
216595024509	4 probable transmembrane helices predicted for PFLU5113 by TMHMM2.0 at aa 13-30, 37-59, 95-117 and 137-159
216595024510	BNR repeat-like domain; Region: BNR_2; pfam13088
216595024511	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
216595024512	Asp-box motif; other site
216595024515	6 probable transmembrane helices predicted for PFLU5115 by TMHMM2.0 at aa 5-27, 32-54, 61-80, 90-112, 125-147 and 167-189
216595024516	Sulfatase; Region: Sulfatase; pfam00884
216595024517	5 probable transmembrane helices predicted for PFLU5116 by TMHMM2.0 at aa 13-35, 55-73, 86-105, 139-161 and 177-199
216595024519	Cytochrome c2 [Energy production and conversion]; Region: COG3474
216595024521	PS00190 Cytochrome c family heme-binding site signature.
216595024522	1 probable transmembrane helix predicted for PFLU5117 by TMHMM2.0 at aa 21-43
216595024523	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
216595024524	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595024525	active site
216595024526	phosphorylation site [posttranslational modification]
216595024527	intermolecular recognition site; other site
216595024528	dimerization interface [polypeptide binding]; other site
216595024530	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
216595024531	heme binding pocket [chemical binding]; other site
216595024532	heme ligand [chemical binding]; other site
216595024534	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
216595024535	GAF domain; Region: GAF; pfam01590
216595024536	Phytochrome region; Region: PHY; pfam00360
216595024537	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595024538	dimer interface [polypeptide binding]; other site
216595024539	phosphorylation site [posttranslational modification]
216595024540	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595024541	ATP binding site [chemical binding]; other site
216595024542	Mg2+ binding site [ion binding]; other site
216595024543	G-X-G motif; other site
216595024549	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
216595024550	metal binding site [ion binding]; metal-binding site
216595024551	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
216595024552	putative active site [active]
216595024553	putative metal binding site [ion binding]; other site
216595024554	Low G+C content region (43.86%)
216595024555	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
216595024557	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
216595024558	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595024559	PAS fold; Region: PAS_3; pfam08447
216595024560	putative active site [active]
216595024561	heme pocket [chemical binding]; other site
216595024562	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
216595024563	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216595024564	metal binding site [ion binding]; metal-binding site
216595024565	active site
216595024566	I-site; other site
216595024569	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
216595024570	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595024571	substrate binding pocket [chemical binding]; other site
216595024572	membrane-bound complex binding site; other site
216595024573	hinge residues; other site
216595024575	PS01039 Bacterial extracellular solute-binding proteins, family 3 signature.
216595024576	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
216595024577	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595024578	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
216595024579	dimerization interface [polypeptide binding]; other site
216595024581	PS00044 Bacterial regulatory proteins, lysR family signature.
216595024583	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
216595024584	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
216595024585	inhibitor-cofactor binding pocket; inhibition site
216595024586	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595024587	catalytic residue [active]
216595024589	PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site.
216595024590	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
216595024592	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
216595024594	5 probable transmembrane helices predicted for PFLU5133 by TMHMM2.0 at aa 10-29, 36-58, 62-79, 92-114 and 129-151
216595024595	putative aminotransferase; Provisional; Region: PRK09105
216595024596	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216595024597	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595024598	homodimer interface [polypeptide binding]; other site
216595024599	catalytic residue [active]
216595024601	protoheme IX farnesyltransferase; Provisional; Region: PRK13362
216595024602	UbiA prenyltransferase family; Region: UbiA; pfam01040
216595024604	PS00943 UbiA prenyltransferase family signature.
216595024605	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
216595024607	PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature.
216595024608	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
216595024609	Subunit I/III interface [polypeptide binding]; other site
216595024610	Subunit III/IV interface [polypeptide binding]; other site
216595024612	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
216595024613	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
216595024614	D-pathway; other site
216595024615	Putative ubiquinol binding site [chemical binding]; other site
216595024616	Low-spin heme (heme b) binding site [chemical binding]; other site
216595024617	Putative water exit pathway; other site
216595024618	Binuclear center (heme o3/CuB) [ion binding]; other site
216595024619	K-pathway; other site
216595024620	Putative proton exit pathway; other site
216595024622	PS00077 Heme-copper oxidase catalytic subunit, copper B binding region signature.
216595024623	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
216595024624	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
216595024625	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
216595024628	low G+C content region (49.77%)
216595024629	disulfide bond formation protein B; Provisional; Region: PRK02110
216595024631	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
216595024632	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
216595024633	heme-binding site [chemical binding]; other site
216595024634	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
216595024635	FAD binding pocket [chemical binding]; other site
216595024636	FAD binding motif [chemical binding]; other site
216595024637	phosphate binding motif [ion binding]; other site
216595024638	beta-alpha-beta structure motif; other site
216595024639	NAD binding pocket [chemical binding]; other site
216595024640	Heme binding  pocket [chemical binding]; other site
216595024644	low G+C content region (37.83%)
216595024645	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
216595024646	GAF domain; Region: GAF; pfam01590
216595024647	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595024648	Walker A motif; other site
216595024649	ATP binding site [chemical binding]; other site
216595024650	Walker B motif; other site
216595024651	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
216595024654	PS00675 Sigma-54 interaction domain ATP-binding region A signature.
216595024655	PS00676 Sigma-54 interaction domain ATP-binding region B signature.
216595024656	PS00688 Sigma-54 interaction domain C-terminal part signature.
216595024658	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
216595024661	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
216595024662	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595024663	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595024665	PS00041 Bacterial regulatory proteins, araC family signature.
216595024667	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
216595024668	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216595024669	DNA binding residues [nucleotide binding]
216595024670	dimerization interface [polypeptide binding]; other site
216595024672	PS00622 Bacterial regulatory proteins, luxR family signature.
216595024674	PS00017 ATP/GTP-binding site motif A (P-loop).
216595024675	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
216595024677	Protein of unknown function (DUF1302); Region: DUF1302; pfam06980
216595024679	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
216595024680	homodimer interface [polypeptide binding]; other site
216595024681	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
216595024682	NAD binding site [chemical binding]; other site
216595024683	active site
216595024684	PS00017 ATP/GTP-binding site motif A (P-loop).
216595024686	PS00061 Short-chain dehydrogenases/reductases family signature.
216595024687	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
216595024689	aldolase II superfamily protein; Provisional; Region: PRK07044
216595024690	intersubunit interface [polypeptide binding]; other site
216595024691	active site
216595024692	Zn2+ binding site [ion binding]; other site
216595024694	flavodoxin; Provisional; Region: PRK05723
216595024696	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595024697	PAS domain; Region: PAS_9; pfam13426
216595024698	putative active site [active]
216595024699	heme pocket [chemical binding]; other site
216595024701	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
216595024702	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
216595024703	DNA binding residues [nucleotide binding]
216595024704	B12 binding domain; Region: B12-binding_2; pfam02607
216595024706	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
216595024707	2 probable transmembrane helices predicted for PFLU5156 by TMHMM2.0 at aa 135-157 and 164-186
216595024708	dihydromonapterin reductase; Provisional; Region: PRK06483
216595024709	pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357
216595024710	NADP binding site [chemical binding]; other site
216595024711	substrate binding pocket [chemical binding]; other site
216595024712	active site
216595024714	PS00061 Short-chain dehydrogenases/reductases family signature.
216595024715	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
216595024716	homodecamer interface [polypeptide binding]; other site
216595024717	GTP cyclohydrolase I; Provisional; Region: PLN03044
216595024718	active site
216595024719	putative catalytic site residues [active]
216595024720	zinc binding site [ion binding]; other site
216595024721	GTP-CH-I/GFRP interaction surface; other site
216595024723	PS00859 GTP cyclohydrolase I signature 1.
216595024724	PS00860 GTP cyclohydrolase I signature 2.
216595024725	D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase; Provisional; Region: folX; PRK11245
216595024726	active site
216595024728	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492
216595024730	PS00017 ATP/GTP-binding site motif A (P-loop).
216595024731	HopJ type III effector protein; Region: HopJ; pfam08888
216595024733	thioredoxin reductase; Provisional; Region: PRK10262
216595024734	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
216595024735	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
216595024738	PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site.
216595024739	putative sulfate transport protein CysZ; Validated; Region: PRK04949
216595024740	4 probable transmembrane helices predicted for PFLU5163 by TMHMM2.0 at aa 24-46, 67-89, 148-170 and 208-230
216595024742	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
216595024743	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
216595024745	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
216595024746	Old yellow enzyme (OYE)-related FMN binding domain, group 5.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747
216595024747	putative active site [active]
216595024748	putative FMN binding site [chemical binding]; other site
216595024749	putative substrate binding site [chemical binding]; other site
216595024750	putative catalytic residue [active]
216595024752	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
216595024753	catalytic residues [active]
216595024754	dimer interface [polypeptide binding]; other site
216595024756	CreA protein; Region: CreA; pfam05981
216595024758	PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature.
216595024759	gamma-glutamyl kinase; Provisional; Region: PRK05429
216595024760	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
216595024761	nucleotide binding site [chemical binding]; other site
216595024762	homotetrameric interface [polypeptide binding]; other site
216595024763	putative phosphate binding site [ion binding]; other site
216595024764	putative allosteric binding site; other site
216595024765	PUA domain; Region: PUA; pfam01472
216595024768	PS00902 Glutamate 5-kinase signature.
216595024769	GTPase CgtA; Reviewed; Region: obgE; PRK12298
216595024770	GTP1/OBG; Region: GTP1_OBG; pfam01018
216595024771	Obg GTPase; Region: Obg; cd01898
216595024772	G1 box; other site
216595024773	GTP/Mg2+ binding site [chemical binding]; other site
216595024774	Switch I region; other site
216595024775	G2 box; other site
216595024776	G3 box; other site
216595024777	Switch II region; other site
216595024778	G4 box; other site
216595024779	G5 box; other site
216595024781	PS00905 GTP1/OBG family signature.
216595024782	PS00017 ATP/GTP-binding site motif A (P-loop).
216595024784	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
216595024786	PS00831 Ribosomal protein L27 signature.
216595024787	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
216595024789	PS01169 Ribosomal protein L21 signature.
216595024790	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
216595024791	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
216595024792	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
216595024793	substrate binding pocket [chemical binding]; other site
216595024794	chain length determination region; other site
216595024795	substrate-Mg2+ binding site; other site
216595024796	catalytic residues [active]
216595024797	aspartate-rich region 1; other site
216595024798	active site lid residues [active]
216595024799	aspartate-rich region 2; other site
216595024801	PS00723 Polyprenyl synthetases signature 1.
216595024802	PS00444 Polyprenyl synthetases signature 2.
216595024803	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
216595024804	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
216595024805	PhnA protein; Region: PhnA; pfam03831
216595024808	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
216595024809	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
216595024810	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
216595024812	PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2.
216595024814	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
216595024815	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595024816	dimerization interface [polypeptide binding]; other site
216595024817	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
216595024818	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595024819	dimer interface [polypeptide binding]; other site
216595024820	putative CheW interface [polypeptide binding]; other site
216595024821	2 probable transmembrane helices predicted for PFLU5176 by TMHMM2.0 at aa 15-37 and 286-308
216595024824	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
216595024825	dimer interface [polypeptide binding]; other site
216595024826	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
216595024827	ligand binding site [chemical binding]; other site
216595024829	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
216595024830	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
216595024831	active site
216595024832	putative substrate binding pocket [chemical binding]; other site
216595024835	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
216595024836	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
216595024837	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
216595024838	putative active site [active]
216595024841	fructuronate transporter; Provisional; Region: PRK10034; cl15264
216595024842	GntP family permease; Region: GntP_permease; pfam02447
216595024844	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755
216595024846	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
216595024847	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
216595024848	Sulfate transporter family; Region: Sulfate_transp; pfam00916
216595024849	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
216595024852	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595024853	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216595024854	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
216595024855	NAD(P) binding site [chemical binding]; other site
216595024856	active site
216595024858	PS00017 ATP/GTP-binding site motif A (P-loop).
216595024859	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595024860	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595024861	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
216595024862	dimerization interface [polypeptide binding]; other site
216595024865	PS00044 Bacterial regulatory proteins, lysR family signature.
216595024867	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595024868	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595024869	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
216595024870	putative dimerization interface [polypeptide binding]; other site
216595024873	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
216595024875	PS00218 Amino acid permeases signature.
216595024876	Kynureninase [Amino acid transport and metabolism]; Region: COG3844
216595024877	kynureninase; Region: kynureninase; TIGR01814
216595024878	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
216595024879	catalytic residue [active]
216595024881	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
216595024882	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
216595024883	putative DNA binding site [nucleotide binding]; other site
216595024884	putative Zn2+ binding site [ion binding]; other site
216595024885	AsnC family; Region: AsnC_trans_reg; pfam01037
216595024887	PS00519 Bacterial regulatory proteins, asnC family signature.
216595024889	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
216595024890	Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460
216595024891	dimer interface [polypeptide binding]; other site
216595024892	active site
216595024894	PS00083 Intradiol ring-cleavage dioxygenases signature.
216595024896	PS00017 ATP/GTP-binding site motif A (P-loop).
216595024897	muconolactone delta-isomerase; Region: muco_delta; TIGR03221
216595024899	muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
216595024900	Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318
216595024901	octamer interface [polypeptide binding]; other site
216595024902	active site
216595024904	PS00909 Mandelate racemase / muconate lactonizing enzyme family signature 2.
216595024906	PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1.
216595024907	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
216595024908	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595024909	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445
216595024910	dimerizarion interface [polypeptide binding]; other site
216595024911	CrgA pocket; other site
216595024912	substrate binding pocket [chemical binding]; other site
216595024915	Helix-turn-helix domain; Region: HTH_18; pfam12833
216595024916	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595024918	PS00041 Bacterial regulatory proteins, araC family signature.
216595024920	anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228
216595024921	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
216595024922	iron-sulfur cluster [ion binding]; other site
216595024923	[2Fe-2S] cluster binding site [ion binding]; other site
216595024924	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
216595024925	putative alpha subunit interface [polypeptide binding]; other site
216595024926	putative active site [active]
216595024927	putative substrate binding site [chemical binding]; other site
216595024928	Fe binding site [ion binding]; other site
216595024930	PS00570 Bacterial ring hydroxylating dioxygenases alpha-subunit signature.
216595024932	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
216595024933	inter-subunit interface; other site
216595024935	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
216595024936	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
216595024937	catalytic loop [active]
216595024938	iron binding site [ion binding]; other site
216595024939	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
216595024940	FAD binding pocket [chemical binding]; other site
216595024941	FAD binding motif [chemical binding]; other site
216595024942	phosphate binding motif [ion binding]; other site
216595024943	beta-alpha-beta structure motif; other site
216595024944	NAD binding pocket [chemical binding]; other site
216595024946	PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature.
216595024949	aromatic amino acid transporter; Provisional; Region: PRK10238
216595024951	12 probable transmembrane helices predicted for PFLU5197 by TMHMM2.0 at aa 21-43, 47-69, 89-111, 121-143, 156-178, 201-223, 243-262, 294-316, 343-365, 369-391, 412-434 and 440-459
216595024952	PS00218 Amino acid permeases signature.
216595024953	tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036
216595024955	arylformamidase; Region: trp_arylform; TIGR03035
216595024957	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
216595024959	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
216595024960	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
216595024962	PS00895 3-hydroxyisobutyrate dehydrogenase signature.
216595024963	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
216595024964	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
216595024965	tetrameric interface [polypeptide binding]; other site
216595024966	NAD binding site [chemical binding]; other site
216595024967	catalytic residues [active]
216595024969	PS00225 Crystallins beta and gamma 'Greek key' motif signature.
216595024970	PS00070 Aldehyde dehydrogenases cysteine active site.
216595024971	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595024972	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595024973	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595024974	LysR substrate binding domain; Region: LysR_substrate; pfam03466
216595024975	dimerization interface [polypeptide binding]; other site
216595024978	Protein of unknown function (DUF3077); Region: DUF3077; pfam11275
216595024979	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
216595024980	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595024981	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
216595024982	substrate binding pocket [chemical binding]; other site
216595024985	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
216595024986	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
216595024987	EamA-like transporter family; Region: EamA; pfam00892
216595024990	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
216595024991	active site
216595024992	iron coordination sites [ion binding]; other site
216595024993	substrate binding pocket [chemical binding]; other site
216595024995	putative outer membrane lipoprotein; Provisional; Region: PRK09967
216595024996	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
216595024997	ligand binding site [chemical binding]; other site
216595024999	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595025000	HAMP domain; Region: HAMP; pfam00672
216595025001	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
216595025002	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216595025003	metal binding site [ion binding]; metal-binding site
216595025004	active site
216595025005	I-site; other site
216595025008	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
216595025009	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
216595025010	AAA domain; Region: AAA_30; pfam13604
216595025011	Family description; Region: UvrD_C_2; pfam13538
216595025012	PS00017 ATP/GTP-binding site motif A (P-loop).
216595025013	PS00024 Hemopexin domain signature.
216595025014	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
216595025015	Family description; Region: UvrD_C_2; pfam13538
216595025016	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
216595025018	PS00017 ATP/GTP-binding site motif A (P-loop).
216595025019	exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
216595025020	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
216595025022	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595025023	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595025024	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
216595025026	TMAO/DMSO reductase; Reviewed; Region: PRK05363
216595025027	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
216595025028	Moco binding site; other site
216595025029	metal coordination site [ion binding]; other site
216595025031	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
216595025032	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
216595025034	PS00379 CDP-alcohol phosphatidyltransferases signature.
216595025035	ketol-acid reductoisomerase; Provisional; Region: PRK05479
216595025036	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
216595025037	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
216595025040	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
216595025041	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
216595025042	putative valine binding site [chemical binding]; other site
216595025043	dimer interface [polypeptide binding]; other site
216595025044	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
216595025046	PS00430 TonB-dependent receptor proteins signature 1.
216595025047	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466
216595025048	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
216595025049	PYR/PP interface [polypeptide binding]; other site
216595025050	dimer interface [polypeptide binding]; other site
216595025051	TPP binding site [chemical binding]; other site
216595025052	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
216595025053	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
216595025054	TPP-binding site [chemical binding]; other site
216595025055	dimer interface [polypeptide binding]; other site
216595025059	PS00044 Bacterial regulatory proteins, lysR family signature.
216595025060	tRNA pseudouridine synthase C; Region: DUF446; pfam04287
216595025062	Tetratricopeptide repeat; Region: TPR_16; pfam13432
216595025063	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
216595025064	TPR motif; other site
216595025066	penicillin-binding protein 1B; Region: PBP_1b; TIGR02071
216595025067	Transglycosylase; Region: Transgly; pfam00912
216595025068	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
216595025070	PS00017 ATP/GTP-binding site motif A (P-loop).
216595025072	1 probable transmembrane helix predicted for PFLU5223 by TMHMM2.0 at aa 21-43
216595025073	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
216595025074	AAA domain; Region: AAA_33; pfam13671
216595025075	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
216595025076	ATP-binding site [chemical binding]; other site
216595025077	Gluconate-6-phosphate binding site [chemical binding]; other site
216595025078	PS00017 ATP/GTP-binding site motif A (P-loop).
216595025079	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
216595025080	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
216595025082	TfoX C-terminal domain; Region: TfoX_C; pfam04994
216595025084	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
216595025085	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
216595025086	Walker A/P-loop; other site
216595025087	ATP binding site [chemical binding]; other site
216595025088	Q-loop/lid; other site
216595025089	ABC transporter signature motif; other site
216595025090	Walker B; other site
216595025091	D-loop; other site
216595025092	H-loop/switch region; other site
216595025094	PS00017 ATP/GTP-binding site motif A (P-loop).
216595025095	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
216595025096	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
216595025097	ABC-ATPase subunit  interface; other site
216595025098	dimer interface [polypeptide binding]; other site
216595025099	putative PBP binding regions; other site
216595025101	ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558
216595025102	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
216595025103	intersubunit interface [polypeptide binding]; other site
216595025105	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
216595025106	iron-sulfur cluster [ion binding]; other site
216595025107	[2Fe-2S] cluster binding site [ion binding]; other site
216595025109	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
216595025111	hypothetical protein; Provisional; Region: PRK08960
216595025112	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216595025113	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595025114	homodimer interface [polypeptide binding]; other site
216595025115	catalytic residue [active]
216595025117	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595025118	PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site.
216595025119	PS00017 ATP/GTP-binding site motif A (P-loop).
216595025120	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
216595025122	PS01102 Prokaryotic dksA/traR C4-type zinc finger.
216595025123	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
216595025124	Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008
216595025125	active site
216595025126	HIGH motif; other site
216595025127	nucleotide binding site [chemical binding]; other site
216595025128	KMSKS motif; other site
216595025130	2 probable transmembrane helices predicted for PFLU5235 by TMHMM2.0 at aa 7-26 and 30-49
216595025131	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
216595025132	Na binding site [ion binding]; other site
216595025133	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
216595025134	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595025135	putative active site [active]
216595025136	heme pocket [chemical binding]; other site
216595025137	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595025138	dimer interface [polypeptide binding]; other site
216595025139	phosphorylation site [posttranslational modification]
216595025140	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595025141	ATP binding site [chemical binding]; other site
216595025142	Mg2+ binding site [ion binding]; other site
216595025143	G-X-G motif; other site
216595025144	14 probable transmembrane helices predicted for PFLU5236 by TMHMM2.0 at aa 5-27, 42-64, 71-93, 113-135, 156-178, 188-210, 244-261, 276-298, 307-329, 333-355, 376-395, 400-422, 429-451 and 471-493
216595025148	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
216595025149	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595025150	active site
216595025151	phosphorylation site [posttranslational modification]
216595025152	intermolecular recognition site; other site
216595025153	dimerization interface [polypeptide binding]; other site
216595025154	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595025155	Walker A motif; other site
216595025156	ATP binding site [chemical binding]; other site
216595025157	Walker B motif; other site
216595025158	arginine finger; other site
216595025161	PS00675 Sigma-54 interaction domain ATP-binding region A signature.
216595025162	PS00676 Sigma-54 interaction domain ATP-binding region B signature.
216595025163	PS00688 Sigma-54 interaction domain C-terminal part signature.
216595025164	poly(A) polymerase; Region: pcnB; TIGR01942
216595025165	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
216595025166	active site
216595025167	NTP binding site [chemical binding]; other site
216595025168	metal binding triad [ion binding]; metal-binding site
216595025169	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
216595025170	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
216595025171	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595025173	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
216595025174	catalytic center binding site [active]
216595025175	ATP binding site [chemical binding]; other site
216595025177	PS00794 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature.
216595025178	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
216595025179	oligomerization interface [polypeptide binding]; other site
216595025180	active site
216595025181	metal binding site [ion binding]; metal-binding site
216595025183	Pantoate-beta-alanine ligase; Region: PanC; cd00560
216595025184	pantoate--beta-alanine ligase; Region: panC; TIGR00018
216595025185	active site
216595025186	ATP-binding site [chemical binding]; other site
216595025187	pantoate-binding site; other site
216595025188	HXXH motif; other site
216595025190	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
216595025191	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
216595025192	active site
216595025193	dimer interface [polypeptide binding]; other site
216595025194	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
216595025195	dimer interface [polypeptide binding]; other site
216595025196	active site
216595025198	PS00765 Phosphoglucose isomerase signature 1.
216595025199	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595025200	PS00174 Phosphoglucose isomerase signature 2.
216595025201	acetyl-CoA synthetase; Provisional; Region: PRK00174
216595025202	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
216595025203	active site
216595025204	CoA binding site [chemical binding]; other site
216595025205	acyl-activating enzyme (AAE) consensus motif; other site
216595025206	AMP binding site [chemical binding]; other site
216595025207	acetate binding site [chemical binding]; other site
216595025209	PS00455 Putative AMP-binding domain signature.
216595025210	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
216595025211	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
216595025212	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
216595025213	putative RNA binding site [nucleotide binding]; other site
216595025214	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595025215	S-adenosylmethionine binding site [chemical binding]; other site
216595025217	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
216595025218	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
216595025219	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
216595025220	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
216595025221	1 probable transmembrane helix predicted for PFLU5247 by TMHMM2.0 at aa 9-31
216595025225	PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide.
216595025226	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
216595025227	BON domain; Region: BON; pfam04972
216595025230	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
216595025231	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
216595025232	RNase E interface [polypeptide binding]; other site
216595025233	trimer interface [polypeptide binding]; other site
216595025234	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
216595025235	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
216595025236	RNase E interface [polypeptide binding]; other site
216595025237	trimer interface [polypeptide binding]; other site
216595025238	active site
216595025239	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
216595025240	putative nucleic acid binding region [nucleotide binding]; other site
216595025241	G-X-X-G motif; other site
216595025242	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
216595025243	RNA binding site [nucleotide binding]; other site
216595025244	domain interface; other site
216595025252	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
216595025253	16S/18S rRNA binding site [nucleotide binding]; other site
216595025254	S13e-L30e interaction site [polypeptide binding]; other site
216595025255	25S rRNA binding site [nucleotide binding]; other site
216595025257	PS00362 Ribosomal protein S15 signature.
216595025258	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
216595025259	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
216595025260	RNA binding site [nucleotide binding]; other site
216595025261	active site
216595025262	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
216595025265	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
216595025267	PS01319 Ribosome-binding factor A signature.
216595025268	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
216595025269	translation initiation factor IF-2; Region: IF-2; TIGR00487
216595025270	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
216595025271	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
216595025272	G1 box; other site
216595025273	putative GEF interaction site [polypeptide binding]; other site
216595025274	GTP/Mg2+ binding site [chemical binding]; other site
216595025275	Switch I region; other site
216595025276	G2 box; other site
216595025277	G3 box; other site
216595025278	Switch II region; other site
216595025279	G4 box; other site
216595025280	G5 box; other site
216595025281	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
216595025282	Translation-initiation factor 2; Region: IF-2; pfam11987
216595025283	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
216595025285	PS01176 Initiation factor 2 signature.
216595025288	PS00017 ATP/GTP-binding site motif A (P-loop).
216595025292	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
216595025293	NusA N-terminal domain; Region: NusA_N; pfam08529
216595025294	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
216595025295	RNA binding site [nucleotide binding]; other site
216595025296	homodimer interface [polypeptide binding]; other site
216595025297	NusA-like KH domain; Region: KH_5; pfam13184
216595025298	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
216595025299	G-X-X-G motif; other site
216595025300	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
216595025301	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
216595025304	PS00037 Myb DNA-binding domain repeat signature 1.
216595025305	ribosome maturation protein RimP; Reviewed; Region: PRK00092
216595025306	Sm and related proteins; Region: Sm_like; cl00259
216595025307	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
216595025308	putative oligomer interface [polypeptide binding]; other site
216595025309	putative RNA binding site [nucleotide binding]; other site
216595025311	Preprotein translocase SecG subunit; Region: SecG; pfam03840
216595025313	triosephosphate isomerase; Provisional; Region: PRK14567
216595025314	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
216595025315	substrate binding site [chemical binding]; other site
216595025316	dimer interface [polypeptide binding]; other site
216595025317	catalytic triad [active]
216595025319	PS00171 Triosephosphate isomerase active site.
216595025320	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
216595025321	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
216595025322	active site
216595025323	substrate binding site [chemical binding]; other site
216595025324	metal binding site [ion binding]; metal-binding site
216595025329	PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature.
216595025330	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
216595025331	dihydropteroate synthase; Region: DHPS; TIGR01496
216595025332	substrate binding pocket [chemical binding]; other site
216595025333	dimer interface [polypeptide binding]; other site
216595025334	inhibitor binding site; inhibition site
216595025336	PS00793 Dihydropteroate synthase signature 2.
216595025337	PS00792 Dihydropteroate synthase signature 1.
216595025338	FtsH Extracellular; Region: FtsH_ext; pfam06480
216595025339	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
216595025340	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595025341	Walker A motif; other site
216595025342	ATP binding site [chemical binding]; other site
216595025343	Walker B motif; other site
216595025344	arginine finger; other site
216595025345	Peptidase family M41; Region: Peptidase_M41; pfam01434
216595025348	PS00674 AAA-protein family signature.
216595025349	PS00017 ATP/GTP-binding site motif A (P-loop).
216595025351	PS00017 ATP/GTP-binding site motif A (P-loop).
216595025352	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
216595025353	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595025354	S-adenosylmethionine binding site [chemical binding]; other site
216595025356	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103
216595025358	PS01301 Uncharacterized protein family UPF0044 signature.
216595025359	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
216595025360	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
216595025361	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
216595025363	PS00830 Prokaryotic transcription elongation factors signature 2.
216595025365	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
216595025366	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
216595025367	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
216595025368	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
216595025369	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
216595025370	ATP-grasp domain; Region: ATP-grasp_4; cl17255
216595025371	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
216595025372	IMP binding site; other site
216595025373	dimer interface [polypeptide binding]; other site
216595025374	interdomain contacts; other site
216595025375	partial ornithine binding site; other site
216595025377	PS00017 ATP/GTP-binding site motif A (P-loop).
216595025378	PS00867 Carbamoyl-phosphate synthase subdomain signature 2.
216595025380	PS00866 Carbamoyl-phosphate synthase subdomain signature 1.
216595025384	PS00867 Carbamoyl-phosphate synthase subdomain signature 2.
216595025385	PS00866 Carbamoyl-phosphate synthase subdomain signature 1.
216595025387	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595025388	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
216595025389	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
216595025390	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
216595025391	catalytic site [active]
216595025392	subunit interface [polypeptide binding]; other site
216595025394	PS00442 Glutamine amidotransferases class-I active site.
216595025396	dihydrodipicolinate reductase; Provisional; Region: PRK00048
216595025397	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
216595025398	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
216595025400	PS01298 Dihydrodipicolinate reductase signature.
216595025402	PS00017 ATP/GTP-binding site motif A (P-loop).
216595025403	chaperone protein DnaJ; Provisional; Region: PRK10767
216595025404	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
216595025405	HSP70 interaction site [polypeptide binding]; other site
216595025406	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
216595025407	substrate binding site [polypeptide binding]; other site
216595025408	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
216595025409	Zn binding sites [ion binding]; other site
216595025410	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
216595025411	dimer interface [polypeptide binding]; other site
216595025414	PS00190 Cytochrome c family heme-binding site signature.
216595025415	PS00637 CXXCXGXG dnaJ domain signature.
216595025417	PS00636 Nt-dnaJ domain signature.
216595025418	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
216595025419	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
216595025420	nucleotide binding site [chemical binding]; other site
216595025422	PS01036 Heat shock hsp70 proteins family signature 3.
216595025423	PS00329 Heat shock hsp70 proteins family signature 2.
216595025424	PS00297 Heat shock hsp70 proteins family signature 1.
216595025425	GrpE; Region: GrpE; pfam01025
216595025426	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
216595025427	dimer interface [polypeptide binding]; other site
216595025428	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
216595025430	PS01071 grpE protein signature.
216595025431	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
216595025432	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
216595025433	Walker A/P-loop; other site
216595025434	ATP binding site [chemical binding]; other site
216595025435	Q-loop/lid; other site
216595025436	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
216595025437	Q-loop/lid; other site
216595025438	ABC transporter signature motif; other site
216595025439	Walker B; other site
216595025440	D-loop; other site
216595025441	H-loop/switch region; other site
216595025443	PS00017 ATP/GTP-binding site motif A (P-loop).
216595025444	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
216595025445	metal binding site 2 [ion binding]; metal-binding site
216595025446	putative DNA binding helix; other site
216595025447	metal binding site 1 [ion binding]; metal-binding site
216595025448	dimer interface [polypeptide binding]; other site
216595025449	structural Zn2+ binding site [ion binding]; other site
216595025451	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
216595025452	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
216595025453	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
216595025454	1 probable transmembrane helix predicted for PFLU5273 by TMHMM2.0 at aa 7-28
216595025455	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595025457	RnfH family Ubiquitin; Region: Ub-RnfH; pfam03658
216595025459	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
216595025460	putative coenzyme Q binding site [chemical binding]; other site
216595025462	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
216595025463	SmpB-tmRNA interface; other site
216595025465	PS01317 Protein smpB signature.
216595025466	Transcriptional regulators [Transcription]; Region: FadR; COG2186
216595025467	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595025468	DNA-binding site [nucleotide binding]; DNA binding site
216595025469	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
216595025472	PS00043 Bacterial regulatory proteins, gntR family signature.
216595025473	glycolate transporter; Provisional; Region: PRK09695
216595025474	L-lactate permease; Region: Lactate_perm; cl00701
216595025475	16 probable transmembrane helices predicted for PFLU5278 by TMHMM2.0 at aa 10-32, 39-58, 73-95, 116-135, 139-161, 168-186, 191-213, 220-242, 252-269, 276-298, 308-330, 335-352, 381-403, 415-434, 444-466 and 541-563
216595025477	PS00043 Bacterial regulatory proteins, gntR family signature.
216595025478	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
216595025479	FAD binding domain; Region: FAD_binding_4; pfam01565
216595025480	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
216595025481	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
216595025485	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
216595025486	PS00017 ATP/GTP-binding site motif A (P-loop).
216595025487	PFI-12
216595025488	integrase; Provisional; Region: PRK09692
216595025489	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
216595025490	active site
216595025491	Int/Topo IB signature motif; other site
216595025494	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
216595025495	multiple promoter invertase; Provisional; Region: mpi; PRK13413
216595025496	catalytic residues [active]
216595025497	catalytic nucleophile [active]
216595025498	Presynaptic Site I dimer interface [polypeptide binding]; other site
216595025499	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
216595025500	Synaptic Flat tetramer interface [polypeptide binding]; other site
216595025501	Synaptic Site I dimer interface [polypeptide binding]; other site
216595025502	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
216595025503	DNA-binding interface [nucleotide binding]; DNA binding site
216595025507	Transposase; Region: HTH_Tnp_1; pfam01527
216595025508	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
216595025510	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
216595025511	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
216595025513	carotene beta-ring hydroxylase; Region: PLN02738
216595025514	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
216595025515	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216595025517	PS01081 Bacterial regulatory proteins, tetR family signature.
216595025518	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595025519	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
216595025520	putative substrate translocation pore; other site
216595025521	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595025522	13 probable transmembrane helices predicted for PFLU5296 by TMHMM2.0 at aa 20-42, 57-79, 86-108, 112-134, 147-169, 174-196, 209-227, 237-256, 276-298, 313-335, 342-361, 366-388 and 476-498
216595025524	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
216595025525	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
216595025526	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595025528	choline dehydrogenase; Validated; Region: PRK02106
216595025529	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
216595025531	PS00017 ATP/GTP-binding site motif A (P-loop).
216595025532	PS00623 GMC oxidoreductases signature 1.
216595025533	PS00624 GMC oxidoreductases signature 2.
216595025535	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
216595025536	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
216595025537	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
216595025538	1 probable transmembrane helix predicted for PFLU5301 by TMHMM2.0 at aa 38-57
216595025540	PS01173 Lipolytic enzymes G-D-X-G family, putative histidine active site.
216595025541	PS01174 Lipolytic enzymes G-D-X-G family, putative serine active site.
216595025542	classical (c) SDRs; Region: SDR_c; cd05233
216595025543	NAD(P) binding site [chemical binding]; other site
216595025544	active site
216595025546	PS00061 Short-chain dehydrogenases/reductases family signature.
216595025547	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
216595025548	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
216595025549	catalytic residues [active]
216595025550	catalytic nucleophile [active]
216595025551	Recombinase; Region: Recombinase; pfam07508
216595025554	ParB-like nuclease domain; Region: ParB; smart00470
216595025555	RepB plasmid partitioning protein; Region: RepB; pfam07506
216595025558	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
216595025559	ParB-like nuclease domain; Region: ParBc; cl02129
216595025560	RepB plasmid partitioning protein; Region: RepB; pfam07506
216595025562	Transposase; Region: HTH_Tnp_1; pfam01527
216595025563	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
216595025565	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
216595025566	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
216595025568	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
216595025569	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
216595025570	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
216595025571	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
216595025572	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
216595025574	Nitrate and nitrite sensing; Region: NIT; pfam08376
216595025575	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
216595025576	HAMP domain; Region: HAMP; pfam00672
216595025577	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595025578	dimer interface [polypeptide binding]; other site
216595025579	putative CheW interface [polypeptide binding]; other site
216595025580	2 probable transmembrane helices predicted for PFLU5309 by TMHMM2.0 at aa 25-44 and 314-336
216595025584	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
216595025585	synthetase active site [active]
216595025586	NTP binding site [chemical binding]; other site
216595025587	metal binding site [ion binding]; metal-binding site
216595025589	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
216595025590	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
216595025591	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595025592	active site
216595025593	phosphorylation site [posttranslational modification]
216595025594	intermolecular recognition site; other site
216595025595	dimerization interface [polypeptide binding]; other site
216595025598	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
216595025599	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
216595025600	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
216595025601	Zn2+ binding site [ion binding]; other site
216595025602	Mg2+ binding site [ion binding]; other site
216595025604	Cache domain; Region: Cache_1; pfam02743
216595025605	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
216595025606	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595025607	dimerization interface [polypeptide binding]; other site
216595025608	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
216595025609	dimerization interface [polypeptide binding]; other site
216595025610	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595025611	dimer interface [polypeptide binding]; other site
216595025612	putative CheW interface [polypeptide binding]; other site
216595025613	2 probable transmembrane helices predicted for PFLU5316 by TMHMM2.0 at aa 10-32 and 355-377
216595025616	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
216595025617	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
216595025619	10 probable transmembrane helices predicted for PFLU5317 by TMHMM2.0 at aa 5-22, 78-100, 110-127, 134-151, 161-195, 208-230, 263-285, 297-316, 320-342 and 358-380
216595025620	hypothetical protein; Provisional; Region: PRK05208
216595025622	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595025623	AAA domain; Region: AAA_32; pfam13654
216595025624	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
216595025625	Protein of unknown function (DUF3015); Region: DUF3015; pfam11220
216595025626	PS00017 ATP/GTP-binding site motif A (P-loop).
216595025627	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
216595025628	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595025629	transcription elongation factor regulatory protein; Validated; Region: PRK06342
216595025630	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
216595025632	glutamate dehydrogenase; Provisional; Region: PRK09414
216595025633	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
216595025634	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
216595025635	NAD(P) binding site [chemical binding]; other site
216595025638	PS00074 Glu / Leu / Phe / Val dehydrogenases active site.
216595025639	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
216595025640	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
216595025641	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
216595025642	ABC transporter; Region: ABC_tran_2; pfam12848
216595025643	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
216595025645	PS00017 ATP/GTP-binding site motif A (P-loop).
216595025647	PS00211 ABC transporters family signature.
216595025648	PS00017 ATP/GTP-binding site motif A (P-loop).
216595025649	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
216595025650	6 probable transmembrane helices predicted for PFLU5328 by TMHMM2.0 at aa 5-27, 34-56, 69-86, 107-129, 134-156 and 176-193
216595025651	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
216595025652	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
216595025653	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
216595025654	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595025655	PAS domain; Region: PAS_9; pfam13426
216595025656	putative active site [active]
216595025657	heme pocket [chemical binding]; other site
216595025658	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
216595025659	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216595025660	metal binding site [ion binding]; metal-binding site
216595025661	active site
216595025662	I-site; other site
216595025663	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
216595025664	2 probable transmembrane helices predicted for PFLU5329 by TMHMM2.0 at aa 28-45 and 258-280
216595025670	PS00225 Crystallins beta and gamma 'Greek key' motif signature.
216595025671	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
216595025672	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
216595025673	dimer interface [polypeptide binding]; other site
216595025674	active site
216595025675	glycine-pyridoxal phosphate binding site [chemical binding]; other site
216595025676	folate binding site [chemical binding]; other site
216595025678	PS00096 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site.
216595025679	putative GTP-binding protein YjiA; Provisional; Region: PRK11537
216595025680	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
216595025681	P-loop, Walker A motif; other site
216595025682	Base recognition motif; other site
216595025683	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
216595025686	PS00017 ATP/GTP-binding site motif A (P-loop).
216595025687	Protein of unknown function (DUF466); Region: DUF466; pfam04328
216595025689	carbon starvation protein A; Provisional; Region: PRK15015
216595025690	Carbon starvation protein CstA; Region: CstA; pfam02554
216595025691	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
216595025693	PilZ domain; Region: PilZ; pfam07238
216595025695	hypothetical protein; Provisional; Region: PRK10621
216595025696	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
216595025698	5 probable transmembrane helices predicted for PFLU5335 by TMHMM2.0 at aa 12-34, 74-96, 101-120, 145-167 and 180-202
216595025699	DNA repair protein RadA; Provisional; Region: PRK11823
216595025700	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
216595025701	Walker A motif/ATP binding site; other site
216595025702	ATP binding site [chemical binding]; other site
216595025703	Walker B motif; other site
216595025704	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
216595025705	PS00017 ATP/GTP-binding site motif A (P-loop).
216595025706	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
216595025707	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
216595025708	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
216595025713	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
216595025714	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
216595025715	tetramer interface [polypeptide binding]; other site
216595025716	heme binding pocket [chemical binding]; other site
216595025718	PS00017 ATP/GTP-binding site motif A (P-loop).
216595025719	PS00437 Catalase proximal heme-ligand signature.
216595025720	PS00438 Catalase proximal active site signature.
216595025721	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
216595025722	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
216595025724	PS01327 Large-conductance mechanosensitive channels mscL family signature.
216595025725	2 probable transmembrane helices predicted for PFLU5340 by TMHMM2.0 at aa 20-42 and 71-93
216595025726	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
216595025727	ferredoxin-NADP reductase; Provisional; Region: PRK10926
216595025728	FAD binding pocket [chemical binding]; other site
216595025729	FAD binding motif [chemical binding]; other site
216595025730	phosphate binding motif [ion binding]; other site
216595025731	beta-alpha-beta structure motif; other site
216595025732	NAD binding pocket [chemical binding]; other site
216595025735	DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188
216595025736	Autoinducer binding domain; Region: Autoind_bind; pfam03472
216595025737	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216595025738	DNA binding residues [nucleotide binding]
216595025739	dimerization interface [polypeptide binding]; other site
216595025742	PS00622 Bacterial regulatory proteins, luxR family signature.
216595025743	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
216595025744	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595025745	S-adenosylmethionine binding site [chemical binding]; other site
216595025747	PS00092 N-6 Adenine-specific DNA methylases signature.
216595025748	Protein of unknown function (DUF2474); Region: DUF2474; pfam10617
216595025749	1 probable transmembrane helix predicted for PFLU5344 by TMHMM2.0 at aa 21-43
216595025750	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
216595025751	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
216595025753	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
216595025755	enterobactin exporter EntS; Provisional; Region: PRK10489
216595025756	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595025757	putative substrate translocation pore; other site
216595025758	8 probable transmembrane helices predicted for PFLU5347 by TMHMM2.0 at aa 15-37, 80-102, 171-193, 221-243, 253-275, 282-304, 309-331 and 369-391
216595025760	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
216595025761	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
216595025762	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
216595025766	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
216595025767	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
216595025770	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
216595025771	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
216595025773	PS00070 Aldehyde dehydrogenases cysteine active site.
216595025775	PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature.
216595025776	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
216595025778	12 probable transmembrane helices predicted for PFLU5352 by TMHMM2.0 at aa 65-87, 94-116, 141-163, 175-197, 217-236, 241-263, 286-308, 328-350, 360-378, 385-407, 422-444 and 457-475
216595025779	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
216595025780	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595025781	S-adenosylmethionine binding site [chemical binding]; other site
216595025783	PS01230 RNA methyltransferase trmA family signature 1.
216595025784	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
216595025785	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
216595025788	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
216595025789	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
216595025790	HlyD family secretion protein; Region: HlyD_3; pfam13437
216595025791	PS00543 HlyD family secretion proteins signature.
216595025793	1 probable transmembrane helix predicted for PFLU5357 by TMHMM2.0 at aa 27-46
216595025794	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
216595025795	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
216595025796	Walker A/P-loop; other site
216595025797	ATP binding site [chemical binding]; other site
216595025798	Q-loop/lid; other site
216595025799	ABC transporter signature motif; other site
216595025800	Walker B; other site
216595025801	D-loop; other site
216595025802	H-loop/switch region; other site
216595025804	PS00211 ABC transporters family signature.
216595025805	PS00017 ATP/GTP-binding site motif A (P-loop).
216595025806	Heme-binding protein A (HasA); Region: HasA; pfam06438
216595025808	Secretin and TonB N terminus short domain; Region: STN; smart00965
216595025809	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
216595025810	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216595025811	N-terminal plug; other site
216595025812	ligand-binding site [chemical binding]; other site
216595025816	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
216595025817	FecR protein; Region: FecR; pfam04773
216595025819	1 probable transmembrane helix predicted for PFLU5362 by TMHMM2.0 at aa 73-90
216595025820	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
216595025821	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
216595025822	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
216595025823	DNA binding residues [nucleotide binding]
216595025826	Dehydroquinase class II; Region: DHquinase_II; pfam01220
216595025827	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
216595025828	active site
216595025829	trimer interface [polypeptide binding]; other site
216595025830	dimer interface [polypeptide binding]; other site
216595025832	PS01029 Dehydroquinase class II signature.
216595025833	shikimate 5-dehydrogenase; Reviewed; Region: PRK12549
216595025834	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
216595025835	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
216595025836	shikimate binding site; other site
216595025837	NAD(P) binding site [chemical binding]; other site
216595025840	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
216595025841	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216595025843	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
216595025844	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
216595025845	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
216595025846	dimer interface [polypeptide binding]; other site
216595025847	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
216595025848	active site
216595025849	Fe binding site [ion binding]; other site
216595025852	PS00216 Sugar transport proteins signature 1.
216595025853	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595025854	D-galactonate transporter; Region: 2A0114; TIGR00893
216595025855	putative substrate translocation pore; other site
216595025856	PS00017 ATP/GTP-binding site motif A (P-loop).
216595025857	10 probable transmembrane helices predicted for PFLU5368 by TMHMM2.0 at aa 76-94, 109-131, 144-166, 228-250, 291-313, 333-355, 362-384, 388-410, 423-445 and 455-477
216595025859	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
216595025860	EamA-like transporter family; Region: EamA; pfam00892
216595025862	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
216595025863	Predicted metalloprotease [General function prediction only]; Region: COG2321
216595025864	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
216595025866	PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.
216595025867	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
216595025868	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216595025869	active site
216595025870	motif I; other site
216595025871	motif II; other site
216595025873	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
216595025874	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
216595025875	active site
216595025876	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
216595025877	catalytic triad [active]
216595025878	dimer interface [polypeptide binding]; other site
216595025881	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
216595025882	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
216595025884	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
216595025885	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
216595025886	putative active site [active]
216595025887	Zn binding site [ion binding]; other site
216595025889	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
216595025890	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
216595025892	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
216595025893	DEAD-like helicases superfamily; Region: DEXDc; smart00487
216595025894	ATP binding site [chemical binding]; other site
216595025895	Mg++ binding site [ion binding]; other site
216595025896	motif III; other site
216595025897	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
216595025898	nucleotide binding region [chemical binding]; other site
216595025899	ATP-binding site [chemical binding]; other site
216595025902	PS00039 DEAD-box subfamily ATP-dependent helicases signature.
216595025903	PS00017 ATP/GTP-binding site motif A (P-loop).
216595025904	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
216595025905	EamA-like transporter family; Region: EamA; pfam00892
216595025906	EamA-like transporter family; Region: EamA; pfam00892
216595025909	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
216595025910	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
216595025911	putative DNA binding site [nucleotide binding]; other site
216595025912	putative Zn2+ binding site [ion binding]; other site
216595025913	AsnC family; Region: AsnC_trans_reg; pfam01037
216595025915	1 probable transmembrane helix predicted for PFLU5382 by TMHMM2.0 at aa 10-29
216595025916	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595025917	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
216595025918	active site
216595025919	catalytic site [active]
216595025920	substrate binding site [chemical binding]; other site
216595025922	Uncharacterized conserved protein [Function unknown]; Region: COG1432
216595025923	LabA_like proteins; Region: LabA; cd10911
216595025924	putative metal binding site [ion binding]; other site
216595025926	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
216595025928	6 probable transmembrane helices predicted for PFLU5387 by TMHMM2.0 at aa 20-42, 52-74, 95-114, 118-137, 158-180 and 195-217
216595025929	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
216595025930	putative catalytic site [active]
216595025931	putative metal binding site [ion binding]; other site
216595025932	putative phosphate binding site [ion binding]; other site
216595025933	1 probable transmembrane helix predicted for PFLU5388 by TMHMM2.0 at aa 7-28
216595025935	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
216595025936	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
216595025937	ATP binding site [chemical binding]; other site
216595025938	putative Mg++ binding site [ion binding]; other site
216595025939	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
216595025940	nucleotide binding region [chemical binding]; other site
216595025941	ATP-binding site [chemical binding]; other site
216595025942	Helicase associated domain (HA2); Region: HA2; pfam04408
216595025943	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
216595025948	PS00017 ATP/GTP-binding site motif A (P-loop).
216595025949	2 probable transmembrane helices predicted for PFLU5390 by TMHMM2.0 at aa 21-43 and 56-78
216595025950	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
216595025951	Cation efflux family; Region: Cation_efflux; cl00316
216595025952	6 probable transmembrane helices predicted for PFLU5391 by TMHMM2.0 at aa 13-35, 39-61, 82-104, 114-136, 160-177 and 182-199
216595025954	Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436
216595025955	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
216595025956	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
216595025957	putative DNA binding site [nucleotide binding]; other site
216595025958	putative Zn2+ binding site [ion binding]; other site
216595025959	AsnC family; Region: AsnC_trans_reg; pfam01037
216595025961	PS00519 Bacterial regulatory proteins, asnC family signature.
216595025963	Protein of unknown function (DUF2788); Region: DUF2788; pfam10981
216595025964	2 probable transmembrane helices predicted for PFLU5394 by TMHMM2.0 at aa 34-56 and 69-91
216595025965	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
216595025966	pseudouridine synthase; Region: TIGR00093
216595025967	active site
216595025969	PS01149 Rsu family of pseudouridine synthase signature.
216595025970	AMP nucleosidase; Provisional; Region: PRK08292
216595025971	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
216595025972	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
216595025974	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
216595025975	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
216595025976	active site
216595025978	PS00073 Acyl-CoA dehydrogenases signature 2.
216595025980	PS00072 Acyl-CoA dehydrogenases signature 1.
216595025982	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
216595025983	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
216595025984	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
216595025985	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595025986	dimer interface [polypeptide binding]; other site
216595025987	phosphorylation site [posttranslational modification]
216595025988	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595025989	ATP binding site [chemical binding]; other site
216595025990	Mg2+ binding site [ion binding]; other site
216595025991	G-X-G motif; other site
216595025992	Response regulator receiver domain; Region: Response_reg; pfam00072
216595025993	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595025994	active site
216595025995	phosphorylation site [posttranslational modification]
216595025996	intermolecular recognition site; other site
216595025997	dimerization interface [polypeptide binding]; other site
216595026003	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
216595026004	dimer interface [polypeptide binding]; other site
216595026005	substrate binding site [chemical binding]; other site
216595026006	ATP binding site [chemical binding]; other site
216595026008	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
216595026009	thiamine phosphate binding site [chemical binding]; other site
216595026010	active site
216595026011	pyrophosphate binding site [ion binding]; other site
216595026013	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
216595026014	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
216595026015	inhibitor-cofactor binding pocket; inhibition site
216595026016	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595026017	catalytic residue [active]
216595026019	PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site.
216595026020	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
216595026021	Sel1 repeat; Region: Sel1; cl02723
216595026022	Sel1-like repeats; Region: SEL1; smart00671
216595026025	Domain of unknown function (DUF1820); Region: DUF1820; pfam08850
216595026027	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
216595026028	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
216595026029	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216595026030	FeS/SAM binding site; other site
216595026031	TRAM domain; Region: TRAM; pfam01938
216595026034	PS01278 Uncharacterized protein family UPF0004 signature.
216595026036	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
216595026037	PhoH-like protein; Region: PhoH; pfam02562
216595026039	PS00017 ATP/GTP-binding site motif A (P-loop).
216595026040	metal-binding heat shock protein; Provisional; Region: PRK00016
216595026042	PS01306 Uncharacterized protein family UPF0054 signature.
216595026043	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
216595026044	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
216595026045	Transporter associated domain; Region: CorC_HlyC; smart01091
216595026048	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
216595026049	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
216595026050	putative active site [active]
216595026051	catalytic triad [active]
216595026052	putative dimer interface [polypeptide binding]; other site
216595026053	6 probable transmembrane helices predicted for PFLU5408 by TMHMM2.0 at aa 13-44, 54-76, 83-105, 160-182, 195-214 and 481-500
216595026055	Uncharacterized conserved protein [Function unknown]; Region: COG1434
216595026056	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
216595026057	putative active site [active]
216595026059	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
216595026060	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
216595026061	HIGH motif; other site
216595026062	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
216595026063	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
216595026064	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
216595026065	active site
216595026066	KMSKS motif; other site
216595026067	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
216595026068	tRNA binding surface [nucleotide binding]; other site
216595026070	PS00178 Aminoacyl-transfer RNA synthetases class-I signature.
216595026073	Lipopolysaccharide-assembly; Region: LptE; cl01125
216595026074	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595026076	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
216595026077	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
216595026079	Domain of unknown function; Region: DUF331; cl01149
216595026081	Transglycosylase SLT domain; Region: SLT_2; pfam13406
216595026082	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
216595026083	N-acetyl-D-glucosamine binding site [chemical binding]; other site
216595026084	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
216595026085	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595026087	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
216595026088	dimer interface [polypeptide binding]; other site
216595026089	catalytic triad [active]
216595026091	lipoyl synthase; Provisional; Region: PRK05481
216595026092	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216595026093	FeS/SAM binding site; other site
216595026095	lipoate-protein ligase B; Provisional; Region: PRK14342
216595026097	PS01313 Lipoate-protein ligase B signature.
216595026098	hypothetical protein; Provisional; Region: PRK00341
216595026100	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
216595026101	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
216595026102	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
216595026105	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
216595026106	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
216595026107	Sporulation related domain; Region: SPOR; pfam05036
216595026110	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595026111	Transglycosylase SLT domain; Region: SLT_2; pfam13406
216595026112	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
216595026113	N-acetyl-D-glucosamine binding site [chemical binding]; other site
216595026114	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
216595026116	PS00428 Cell cycle proteins ftsW / rodA / spoVE signature.
216595026117	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
216595026118	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
216595026119	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
216595026122	PS00017 ATP/GTP-binding site motif A (P-loop).
216595026123	1 probable transmembrane helix predicted for PFLU5423 by TMHMM2.0 at aa 20-42
216595026124	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
216595026126	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
216595026128	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
216595026129	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
216595026130	active site
216595026131	(T/H)XGH motif; other site
216595026133	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
216595026134	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
216595026135	putative catalytic cysteine [active]
216595026137	PS01223 Gamma-glutamyl phosphate reductase signature.
216595026138	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
216595026139	active site
216595026140	DNA binding site [nucleotide binding]
216595026142	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
216595026143	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
216595026144	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
216595026145	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
216595026146	active site
216595026147	11 probable transmembrane helices predicted for PFLU5429 by TMHMM2.0 at aa 21-52, 62-81, 145-167, 177-199, 206-228, 263-277, 282-304, 319-341, 348-370, 374-396 and 409-431
216595026150	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
216595026152	LrgB-like family; Region: LrgB; pfam04172
216595026154	LrgA family; Region: LrgA; pfam03788
216595026156	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
216595026157	putative active site [active]
216595026158	putative catalytic site [active]
216595026160	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
216595026161	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
216595026162	Peptidase C13 family; Region: Peptidase_C13; pfam01650
216595026163	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595026175	PS00225 Crystallins beta and gamma 'Greek key' motif signature.
216595026176	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
216595026177	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
216595026178	NAD binding site [chemical binding]; other site
216595026179	active site
216595026181	Protein of unknown function (DUF1375); Region: DUF1375; cl11456
216595026183	aromatic acid decarboxylase; Validated; Region: PRK05920
216595026184	Flavoprotein; Region: Flavoprotein; pfam02441
216595026186	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
216595026187	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
216595026188	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
216595026189	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
216595026193	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
216595026194	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595026195	Walker A motif; other site
216595026196	ATP binding site [chemical binding]; other site
216595026197	Walker B motif; other site
216595026198	arginine finger; other site
216595026199	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
216595026201	PS00688 Sigma-54 interaction domain C-terminal part signature.
216595026203	PS00676 Sigma-54 interaction domain ATP-binding region B signature.
216595026204	PS00675 Sigma-54 interaction domain ATP-binding region A signature.
216595026206	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
216595026207	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
216595026208	NAD(P) binding site [chemical binding]; other site
216595026209	catalytic residues [active]
216595026211	PS00017 ATP/GTP-binding site motif A (P-loop).
216595026212	PS00687 Aldehyde dehydrogenases glutamic acid active site.
216595026213	PS00070 Aldehyde dehydrogenases cysteine active site.
216595026214	ethanolamine permease; Region: 2A0305; TIGR00908
216595026215	12 probable transmembrane helices predicted for PFLU5442 by TMHMM2.0 at aa 28-50, 60-82, 107-129, 139-161, 166-188, 208-230, 251-273, 300-322, 347-366, 371-393, 406-428 and 433-452
216595026217	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595026218	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
216595026219	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
216595026221	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
216595026223	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
216595026224	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216595026225	Coenzyme A binding pocket [chemical binding]; other site
216595026227	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
216595026228	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
216595026229	5 probable transmembrane helices predicted for PFLU5446 by TMHMM2.0 at aa 28-50, 57-79, 129-148, 155-177 and 187-209
216595026231	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167
216595026233	PS00142 Neutral zinc metallopeptidases, zinc-binding region signature.
216595026234	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
216595026235	dimer interface [polypeptide binding]; other site
216595026236	substrate binding site [chemical binding]; other site
216595026237	metal binding sites [ion binding]; metal-binding site
216595026239	PS00387 Inorganic pyrophosphatase signature.
216595026240	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216595026241	non-specific DNA binding site [nucleotide binding]; other site
216595026242	salt bridge; other site
216595026243	sequence-specific DNA binding site [nucleotide binding]; other site
216595026244	Predicted transcriptional regulator [Transcription]; Region: COG2932
216595026245	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
216595026246	Catalytic site [active]
216595026248	Isochorismatase family; Region: Isochorismatase; pfam00857
216595026249	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
216595026250	catalytic triad [active]
216595026251	dimer interface [polypeptide binding]; other site
216595026252	conserved cis-peptide bond; other site
216595026254	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
216595026255	GAF domain; Region: GAF; pfam01590
216595026256	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595026257	dimer interface [polypeptide binding]; other site
216595026258	phosphorylation site [posttranslational modification]
216595026259	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595026260	ATP binding site [chemical binding]; other site
216595026261	Mg2+ binding site [ion binding]; other site
216595026262	G-X-G motif; other site
216595026266	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
216595026267	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
216595026268	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
216595026270	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
216595026271	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
216595026273	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
216595026274	Helix-Turn-Helix DNA binding domain of MerR2-like transcription regulators; Region: HTH_MerR2; cd04769
216595026275	DNA binding residues [nucleotide binding]
216595026276	putative dimer interface [polypeptide binding]; other site
216595026279	Fic family protein [Function unknown]; Region: COG3177
216595026280	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
216595026281	Fic/DOC family; Region: Fic; pfam02661
216595026283	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
216595026285	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
216595026286	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
216595026287	substrate binding pocket [chemical binding]; other site
216595026288	chain length determination region; other site
216595026289	substrate-Mg2+ binding site; other site
216595026290	catalytic residues [active]
216595026291	aspartate-rich region 1; other site
216595026292	active site lid residues [active]
216595026293	aspartate-rich region 2; other site
216595026295	PS00723 Polyprenyl synthetases signature 1.
216595026296	PS00444 Polyprenyl synthetases signature 2.
216595026297	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
216595026298	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
216595026299	TPP-binding site; other site
216595026300	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
216595026301	PYR/PP interface [polypeptide binding]; other site
216595026302	dimer interface [polypeptide binding]; other site
216595026303	TPP binding site [chemical binding]; other site
216595026304	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
216595026307	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
216595026308	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216595026309	N-terminal plug; other site
216595026310	ligand-binding site [chemical binding]; other site
216595026313	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
216595026314	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
216595026315	cobalamin binding residues [chemical binding]; other site
216595026316	putative BtuC binding residues; other site
216595026317	dimer interface [polypeptide binding]; other site
216595026319	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
216595026320	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
216595026321	dimerization interface [polypeptide binding]; other site
216595026322	active site
216595026324	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
216595026325	thiamine monophosphate kinase; Provisional; Region: PRK05731
216595026326	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
216595026327	ATP binding site [chemical binding]; other site
216595026328	dimerization interface [polypeptide binding]; other site
216595026331	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
216595026333	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
216595026334	homopentamer interface [polypeptide binding]; other site
216595026335	active site
216595026337	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
216595026338	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
216595026339	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
216595026340	dimerization interface [polypeptide binding]; other site
216595026341	active site
216595026344	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
216595026345	Lumazine binding domain; Region: Lum_binding; pfam00677
216595026346	Lumazine binding domain; Region: Lum_binding; pfam00677
216595026349	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
216595026350	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
216595026351	catalytic motif [active]
216595026352	Zn binding site [ion binding]; other site
216595026353	RibD C-terminal domain; Region: RibD_C; cl17279
216595026356	PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature.
216595026357	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
216595026358	ATP cone domain; Region: ATP-cone; pfam03477
216595026360	Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825
216595026361	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595026362	Predicted methyltransferase [General function prediction only]; Region: COG3897
216595026363	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
216595026365	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
216595026366	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
216595026368	PS00194 Thioredoxin family active site.
216595026369	Protein of unknown function (DUF2796); Region: DUF2796; pfam10986
216595026370	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
216595026371	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
216595026372	Walker A/P-loop; other site
216595026373	ATP binding site [chemical binding]; other site
216595026374	Q-loop/lid; other site
216595026375	ABC transporter signature motif; other site
216595026376	Walker B; other site
216595026377	D-loop; other site
216595026378	H-loop/switch region; other site
216595026380	PS00017 ATP/GTP-binding site motif A (P-loop).
216595026381	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
216595026382	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
216595026383	FtsX-like permease family; Region: FtsX; pfam02687
216595026384	4 probable transmembrane helices predicted for PFLU5481 by TMHMM2.0 at aa 13-35, 293-315, 336-358 and 387-409
216595026386	Protein of unknown function (DUF3299); Region: DUF3299; pfam11736
216595026387	OmpW family; Region: OmpW; cl17427
216595026389	PS00695 Enterobacterial virulence outer membrane protein signature 2.
216595026390	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
216595026391	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
216595026392	NAD(P) binding site [chemical binding]; other site
216595026393	active site
216595026395	Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201
216595026396	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
216595026397	ATP binding site [chemical binding]; other site
216595026398	putative Mg++ binding site [ion binding]; other site
216595026399	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
216595026400	nucleotide binding region [chemical binding]; other site
216595026401	ATP-binding site [chemical binding]; other site
216595026402	DEAD/H associated; Region: DEAD_assoc; pfam08494
216595026404	PS00017 ATP/GTP-binding site motif A (P-loop).
216595026405	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
216595026407	PS00041 Bacterial regulatory proteins, araC family signature.
216595026409	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
216595026410	Mechanosensitive ion channel; Region: MS_channel; pfam00924
216595026413	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
216595026414	putative catalytic site [active]
216595026415	putative metal binding site [ion binding]; other site
216595026416	putative phosphate binding site [ion binding]; other site
216595026418	cardiolipin synthase 2; Provisional; Region: PRK11263
216595026419	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
216595026420	putative active site [active]
216595026421	catalytic site [active]
216595026422	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
216595026423	putative active site [active]
216595026424	catalytic site [active]
216595026427	Predicted integral membrane protein [Function unknown]; Region: COG0392
216595026428	8 probable transmembrane helices predicted for PFLU5489 by TMHMM2.0 at aa 15-32, 52-71, 86-108, 128-150, 165-187, 207-229, 239-261 and 282-304
216595026429	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
216595026430	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
216595026432	PS00708 Prolyl endopeptidase family serine active site.
216595026433	Protein of unknown function (DUF3182); Region: DUF3182; pfam11379
216595026434	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
216595026435	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
216595026436	conserved cys residue [active]
216595026437	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595026439	PS00041 Bacterial regulatory proteins, araC family signature.
216595026441	Isochorismatase family; Region: Isochorismatase; pfam00857
216595026442	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
216595026443	catalytic triad [active]
216595026444	conserved cis-peptide bond; other site
216595026446	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
216595026447	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595026448	S-adenosylmethionine binding site [chemical binding]; other site
216595026450	Domain of unknown function (DUF4365); Region: DUF4365; pfam14280
216595026451	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
216595026452	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
216595026453	dimer interface [polypeptide binding]; other site
216595026454	ssDNA binding site [nucleotide binding]; other site
216595026455	tetramer (dimer of dimers) interface [polypeptide binding]; other site
216595026457	PS00736 Single-strand binding protein family signature 2.
216595026458	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595026459	Major Facilitator Superfamily; Region: MFS_1; pfam07690
216595026460	putative substrate translocation pore; other site
216595026462	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
216595026463	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
216595026464	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
216595026465	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
216595026466	PS00017 ATP/GTP-binding site motif A (P-loop).
216595026467	PS00211 ABC transporters family signature.
216595026469	PS00017 ATP/GTP-binding site motif A (P-loop).
216595026470	PS00211 ABC transporters family signature.
216595026471	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
216595026472	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
216595026473	heme binding site [chemical binding]; other site
216595026474	ferroxidase pore; other site
216595026475	ferroxidase diiron center [ion binding]; other site
216595026477	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
216595026478	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
216595026479	tetramer interface [polypeptide binding]; other site
216595026480	heme binding pocket [chemical binding]; other site
216595026481	NADPH binding site [chemical binding]; other site
216595026483	PS00437 Catalase proximal heme-ligand signature.
216595026484	PS00438 Catalase proximal active site signature.
216595026485	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
216595026487	PS01167 Ribosomal protein L17 signature.
216595026488	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
216595026489	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
216595026490	alphaNTD homodimer interface [polypeptide binding]; other site
216595026491	alphaNTD - beta interaction site [polypeptide binding]; other site
216595026492	alphaNTD - beta' interaction site [polypeptide binding]; other site
216595026493	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
216595026497	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
216595026498	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
216595026499	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
216595026500	RNA binding surface [nucleotide binding]; other site
216595026502	PS00632 Ribosomal protein S4 signature.
216595026504	30S ribosomal protein S11; Validated; Region: PRK05309
216595026506	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
216595026507	30S ribosomal protein S13; Region: bact_S13; TIGR03631
216595026509	PS00646 Ribosomal protein S13 signature.
216595026510	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
216595026512	PS00828 Ribosomal protein L36 signature.
216595026513	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
216595026514	SecY translocase; Region: SecY; pfam00344
216595026516	PS00095 C-5 cytosine-specific DNA methylases C-terminal signature.
216595026517	PS00756 Protein secY signature 2.
216595026518	PS00755 Protein secY signature 1.
216595026519	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
216595026520	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
216595026523	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
216595026524	23S rRNA binding site [nucleotide binding]; other site
216595026526	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
216595026527	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
216595026528	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
216595026531	PS00585 Ribosomal protein S5 signature.
216595026532	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
216595026533	5S rRNA interface [nucleotide binding]; other site
216595026534	23S rRNA interface [nucleotide binding]; other site
216595026535	L5 interface [polypeptide binding]; other site
216595026537	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
216595026538	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
216595026539	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
216595026541	PS00525 Ribosomal protein L6 signature 1.
216595026543	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
216595026545	PS00294 Prenyl group binding site (CAAX box).
216595026546	PS00053 Ribosomal protein S8 signature.
216595026547	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
216595026549	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
216595026550	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
216595026551	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
216595026554	PS00358 Ribosomal protein L5 signature.
216595026555	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
216595026556	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
216595026557	RNA binding site [nucleotide binding]; other site
216595026559	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
216595026561	PS00049 Ribosomal protein L14 signature.
216595026562	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
216595026564	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
216595026565	23S rRNA interface [nucleotide binding]; other site
216595026566	putative translocon interaction site; other site
216595026567	signal recognition particle (SRP54) interaction site; other site
216595026568	L23 interface [polypeptide binding]; other site
216595026569	trigger factor interaction site; other site
216595026571	PS00579 Ribosomal protein L29 signature.
216595026572	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
216595026573	23S rRNA interface [nucleotide binding]; other site
216595026574	5S rRNA interface [nucleotide binding]; other site
216595026575	putative antibiotic binding site [chemical binding]; other site
216595026576	L25 interface [polypeptide binding]; other site
216595026577	L27 interface [polypeptide binding]; other site
216595026579	PS00701 Ribosomal protein L16 signature 2.
216595026580	PS00586 Ribosomal protein L16 signature 1.
216595026581	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
216595026582	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
216595026583	G-X-X-G motif; other site
216595026584	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
216595026586	PS00548 Ribosomal protein S3 signature.
216595026589	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
216595026590	protein-rRNA interface [nucleotide binding]; other site
216595026591	putative translocon binding site; other site
216595026593	PS00464 Ribosomal protein L22 signature.
216595026594	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
216595026596	PS00323 Ribosomal protein S19 signature.
216595026597	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
216595026598	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
216595026599	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
216595026601	PS00467 Ribosomal protein L2 signature.
216595026603	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
216595026605	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
216595026607	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
216595026609	PS00474 Ribosomal protein L3 signature.
216595026610	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
216595026612	PS00361 Ribosomal protein S10 signature.
216595026613	elongation factor Tu; Reviewed; Region: PRK00049
216595026614	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
216595026615	G1 box; other site
216595026616	GEF interaction site [polypeptide binding]; other site
216595026617	GTP/Mg2+ binding site [chemical binding]; other site
216595026618	Switch I region; other site
216595026619	G2 box; other site
216595026620	G3 box; other site
216595026621	Switch II region; other site
216595026622	G4 box; other site
216595026623	G5 box; other site
216595026624	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
216595026625	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
216595026626	Antibiotic Binding Site [chemical binding]; other site
216595026630	PS00301 GTP-binding elongation factors signature.
216595026631	PS00017 ATP/GTP-binding site motif A (P-loop).
216595026632	elongation factor G; Reviewed; Region: PRK00007
216595026633	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
216595026634	G1 box; other site
216595026635	putative GEF interaction site [polypeptide binding]; other site
216595026636	GTP/Mg2+ binding site [chemical binding]; other site
216595026637	Switch I region; other site
216595026638	G2 box; other site
216595026639	G3 box; other site
216595026640	Switch II region; other site
216595026641	G4 box; other site
216595026642	G5 box; other site
216595026643	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
216595026644	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
216595026645	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
216595026650	PS00301 GTP-binding elongation factors signature.
216595026651	PS00017 ATP/GTP-binding site motif A (P-loop).
216595026652	30S ribosomal protein S7; Validated; Region: PRK05302
216595026654	PS00052 Ribosomal protein S7 signature.
216595026655	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
216595026656	S17 interaction site [polypeptide binding]; other site
216595026657	S8 interaction site; other site
216595026658	16S rRNA interaction site [nucleotide binding]; other site
216595026659	streptomycin interaction site [chemical binding]; other site
216595026660	23S rRNA interaction site [nucleotide binding]; other site
216595026661	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
216595026663	PS00055 Ribosomal protein S12 signature.
216595026664	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
216595026665	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
216595026666	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
216595026667	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
216595026668	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
216595026669	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
216595026670	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
216595026671	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
216595026672	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
216595026673	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
216595026674	DNA binding site [nucleotide binding]
216595026675	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
216595026681	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
216595026682	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
216595026683	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
216595026684	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
216595026685	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
216595026686	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
216595026687	RPB3 interaction site [polypeptide binding]; other site
216595026688	RPB1 interaction site [polypeptide binding]; other site
216595026689	RPB11 interaction site [polypeptide binding]; other site
216595026690	RPB10 interaction site [polypeptide binding]; other site
216595026693	PS01166 RNA polymerases beta chain signature.
216595026694	PS00223 Annexins repeated domain signature.
216595026698	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
216595026699	peripheral dimer interface [polypeptide binding]; other site
216595026700	core dimer interface [polypeptide binding]; other site
216595026701	L10 interface [polypeptide binding]; other site
216595026702	L11 interface [polypeptide binding]; other site
216595026703	putative EF-Tu interaction site [polypeptide binding]; other site
216595026704	putative EF-G interaction site [polypeptide binding]; other site
216595026706	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
216595026707	23S rRNA interface [nucleotide binding]; other site
216595026708	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
216595026710	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
216595026711	mRNA/rRNA interface [nucleotide binding]; other site
216595026713	PS01199 Ribosomal protein L1 signature.
216595026714	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
216595026715	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
216595026716	23S rRNA interface [nucleotide binding]; other site
216595026717	L7/L12 interface [polypeptide binding]; other site
216595026718	putative thiostrepton binding site; other site
216595026719	L25 interface [polypeptide binding]; other site
216595026720	PS00359 Ribosomal protein L11 signature.
216595026723	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
216595026724	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
216595026725	putative homodimer interface [polypeptide binding]; other site
216595026726	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
216595026727	heterodimer interface [polypeptide binding]; other site
216595026728	homodimer interface [polypeptide binding]; other site
216595026729	PS01014 Transcription termination factor nusG signature.
216595026732	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
216595026734	PS01067 Protein secE/sec61-gamma signature.
216595026735	pantothenate kinase; Reviewed; Region: PRK13322
216595026736	PS00294 Prenyl group binding site (CAAX box).
216595026738	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
216595026739	Biotin operon repressor [Transcription]; Region: BirA; COG1654
216595026740	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
216595026743	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
216595026744	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
216595026745	active site
216595026746	HIGH motif; other site
216595026747	dimer interface [polypeptide binding]; other site
216595026748	KMSKS motif; other site
216595026751	PS00178 Aminoacyl-transfer RNA synthetases class-I signature.
216595026752	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
216595026753	Peptidase family M23; Region: Peptidase_M23; pfam01551
216595026755	1 probable transmembrane helix predicted for PFLU5545 by TMHMM2.0 at aa 16-35
216595026758	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
216595026760	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
216595026761	PS01152 Hypothetical hesB/yadR/yfhF family signature.
216595026763	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
216595026764	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
216595026767	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
216595026769	4 probable transmembrane helices predicted for PFLU5549 by TMHMM2.0 at aa 10-29, 50-72, 82-104 and 117-139
216595026770	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
216595026771	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
216595026772	FMN binding site [chemical binding]; other site
216595026773	substrate binding site [chemical binding]; other site
216595026774	putative catalytic residue [active]
216595026775	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595026777	Protein of unknown function (DUF805); Region: DUF805; pfam05656
216595026779	4 probable transmembrane helices predicted for PFLU5551 by TMHMM2.0 at aa 139-161, 171-193, 205-227 and 247-269
216595026780	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
216595026781	classical (c) SDRs; Region: SDR_c; cd05233
216595026782	NAD(P) binding site [chemical binding]; other site
216595026783	active site
216595026785	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
216595026786	nucleotide binding site/active site [active]
216595026787	HIT family signature motif; other site
216595026788	catalytic residue [active]
216595026790	PS00892 HIT family signature.
216595026791	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
216595026792	diiron binding motif [ion binding]; other site
216595026793	OsmC-like protein; Region: OsmC; cl00767
216595026795	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
216595026796	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
216595026797	ligand binding site [chemical binding]; other site
216595026798	flexible hinge region; other site
216595026799	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
216595026800	putative switch regulator; other site
216595026801	non-specific DNA interactions [nucleotide binding]; other site
216595026802	DNA binding site [nucleotide binding]
216595026803	sequence specific DNA binding site [nucleotide binding]; other site
216595026804	putative cAMP binding site [chemical binding]; other site
216595026806	PS00889 Cyclic nucleotide-binding domain signature 2.
216595026808	PS00042 Bacterial regulatory proteins, crp family signature.
216595026809	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
216595026810	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
216595026811	active site
216595026812	ribulose/triose binding site [chemical binding]; other site
216595026813	phosphate binding site [ion binding]; other site
216595026814	substrate (anthranilate) binding pocket [chemical binding]; other site
216595026815	product (indole) binding pocket [chemical binding]; other site
216595026817	PS00614 Indole-3-glycerol phosphate synthase signature.
216595026818	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
216595026819	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
216595026820	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
216595026822	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595026824	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
216595026825	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
216595026826	glutamine binding [chemical binding]; other site
216595026827	catalytic triad [active]
216595026829	PS00037 Myb DNA-binding domain repeat signature 1.
216595026830	PS00442 Glutamine amidotransferases class-I active site.
216595026831	anthranilate synthase component I; Provisional; Region: PRK13565
216595026832	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
216595026833	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
216595026836	phosphoglycolate phosphatase; Provisional; Region: PRK13223
216595026837	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216595026838	motif II; other site
216595026840	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
216595026841	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
216595026842	substrate binding site [chemical binding]; other site
216595026843	hexamer interface [polypeptide binding]; other site
216595026844	metal binding site [ion binding]; metal-binding site
216595026846	PS01086 Ribulose-phosphate 3-epimerase family signature 2.
216595026847	PS01085 Ribulose-phosphate 3-epimerase family signature 1.
216595026848	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
216595026849	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
216595026850	active site
216595026851	NAD binding site [chemical binding]; other site
216595026852	metal binding site [ion binding]; metal-binding site
216595026854	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
216595026855	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595026856	dimer interface [polypeptide binding]; other site
216595026857	conserved gate region; other site
216595026858	putative PBP binding loops; other site
216595026859	ABC-ATPase subunit interface; other site
216595026861	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595026862	PS00430 TonB-dependent receptor proteins signature 1.
216595026863	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595026864	dimer interface [polypeptide binding]; other site
216595026865	conserved gate region; other site
216595026866	putative PBP binding loops; other site
216595026867	ABC-ATPase subunit interface; other site
216595026869	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595026871	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
216595026872	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
216595026874	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
216595026875	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
216595026876	Walker A/P-loop; other site
216595026877	ATP binding site [chemical binding]; other site
216595026878	Q-loop/lid; other site
216595026879	ABC transporter signature motif; other site
216595026880	Walker B; other site
216595026881	D-loop; other site
216595026882	H-loop/switch region; other site
216595026883	TOBE domain; Region: TOBE_2; pfam08402
216595026886	PS00211 ABC transporters family signature.
216595026887	PS00017 ATP/GTP-binding site motif A (P-loop).
216595026888	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
216595026889	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595026890	active site
216595026891	phosphorylation site [posttranslational modification]
216595026892	intermolecular recognition site; other site
216595026893	dimerization interface [polypeptide binding]; other site
216595026894	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
216595026895	DNA binding residues [nucleotide binding]
216595026896	dimerization interface [polypeptide binding]; other site
216595026898	PS00622 Bacterial regulatory proteins, luxR family signature.
216595026900	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595026901	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
216595026902	substrate binding pocket [chemical binding]; other site
216595026903	membrane-bound complex binding site; other site
216595026904	hinge residues; other site
216595026905	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595026906	putative active site [active]
216595026907	heme pocket [chemical binding]; other site
216595026908	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
216595026909	Histidine kinase; Region: HisKA_3; pfam07730
216595026910	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595026911	ATP binding site [chemical binding]; other site
216595026912	Mg2+ binding site [ion binding]; other site
216595026913	G-X-G motif; other site
216595026917	Protein of unknown function (DUF3530); Region: DUF3530; pfam12048
216595026918	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
216595026919	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
216595026920	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
216595026921	putative metal binding site [ion binding]; other site
216595026922	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
216595026923	HSP70 interaction site [polypeptide binding]; other site
216595026925	PS00017 ATP/GTP-binding site motif A (P-loop).
216595026926	1 probable transmembrane helix predicted for PFLU5572 by TMHMM2.0 at aa 21-43
216595026927	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
216595026928	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
216595026929	Substrate binding site; other site
216595026930	metal-binding site
216595026932	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
216595026933	Phosphotransferase enzyme family; Region: APH; pfam01636
216595026935	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
216595026936	OstA-like protein; Region: OstA; cl00844
216595026937	Organic solvent tolerance protein; Region: OstA_C; pfam04453
216595026940	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
216595026941	SurA N-terminal domain; Region: SurA_N; pfam09312
216595026942	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
216595026943	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
216595026947	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
216595026948	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
216595026950	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
216595026951	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
216595026952	S-adenosylmethionine binding site [chemical binding]; other site
216595026954	PS01131 Ribosomal RNA adenine dimethylases signature.
216595026955	PS00290 Immunoglobulins and major histocompatibility complex proteins signature.
216595026956	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
216595026958	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
216595026959	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
216595026960	active site
216595026961	metal binding site [ion binding]; metal-binding site
216595026963	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
216595026964	active site residue [active]
216595026966	PrkA family serine protein kinase; Provisional; Region: PRK15455
216595026967	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
216595026969	PS00017 ATP/GTP-binding site motif A (P-loop).
216595026970	PS00107 Protein kinases ATP-binding region signature.
216595026972	hypothetical protein; Provisional; Region: PRK05325
216595026974	SpoVR family protein; Provisional; Region: PRK11767
216595026975	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
216595026977	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
216595026978	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
216595026979	active site
216595026980	NTP binding site [chemical binding]; other site
216595026981	metal binding triad [ion binding]; metal-binding site
216595026982	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
216595026983	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
216595026984	Zn2+ binding site [ion binding]; other site
216595026985	Mg2+ binding site [ion binding]; other site
216595026988	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
216595026989	catalytic center binding site [active]
216595026990	ATP binding site [chemical binding]; other site
216595026992	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
216595026993	homooctamer interface [polypeptide binding]; other site
216595026994	active site
216595026996	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
216595026997	4 probable transmembrane helices predicted for PFLU5588 by TMHMM2.0 at aa 2-24, 80-99, 112-134 and 149-171
216595026999	UGMP family protein; Validated; Region: PRK09604
216595027000	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
216595027002	1 probable transmembrane helix predicted for PFLU5590 by TMHMM2.0 at aa 35-57
216595027003	DNA primase, catalytic core; Region: dnaG; TIGR01391
216595027004	CHC2 zinc finger; Region: zf-CHC2; pfam01807
216595027005	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
216595027006	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
216595027007	active site
216595027008	metal binding site [ion binding]; metal-binding site
216595027009	interdomain interaction site; other site
216595027010	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
216595027011	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
216595027016	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
216595027017	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
216595027018	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
216595027019	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
216595027020	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
216595027021	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
216595027022	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
216595027023	DNA binding residues [nucleotide binding]
216595027028	PS00715 Sigma-70 factors family signature 1.
216595027031	PS00716 Sigma-70 factors family signature 2.
216595027032	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
216595027033	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595027034	substrate binding pocket [chemical binding]; other site
216595027035	membrane-bound complex binding site; other site
216595027036	hinge residues; other site
216595027037	PAS domain S-box; Region: sensory_box; TIGR00229
216595027038	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595027039	putative active site [active]
216595027040	heme pocket [chemical binding]; other site
216595027041	PAS domain S-box; Region: sensory_box; TIGR00229
216595027042	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595027043	putative active site [active]
216595027044	heme pocket [chemical binding]; other site
216595027045	PAS domain; Region: PAS_9; pfam13426
216595027046	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595027047	PAS domain; Region: PAS_9; pfam13426
216595027048	putative active site [active]
216595027049	heme pocket [chemical binding]; other site
216595027050	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
216595027051	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216595027052	metal binding site [ion binding]; metal-binding site
216595027053	active site
216595027054	I-site; other site
216595027055	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
216595027057	1 probable transmembrane helix predicted for PFLU5593 by TMHMM2.0 at aa 338-360
216595027060	PS00017 ATP/GTP-binding site motif A (P-loop).
216595027065	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
216595027066	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
216595027067	putative DNA binding site [nucleotide binding]; other site
216595027068	putative Zn2+ binding site [ion binding]; other site
216595027069	AsnC family; Region: AsnC_trans_reg; pfam01037
216595027071	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
216595027073	Predicted amidohydrolase [General function prediction only]; Region: COG0388
216595027074	Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576
216595027075	putative active site [active]
216595027076	catalytic triad [active]
216595027077	putative dimer interface [polypeptide binding]; other site
216595027079	PS01227 Uncharacterized protein family UPF0012 signature.
216595027080	coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110
216595027081	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
216595027082	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
216595027083	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
216595027085	PS00143 Insulinase family, zinc-binding region signature.
216595027088	coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284
216595027090	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
216595027091	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
216595027092	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
216595027094	pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079
216595027096	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
216595027097	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216595027098	FeS/SAM binding site; other site
216595027099	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
216595027101	PS01305 moaA / nifB / pqqE family signature.
216595027102	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
216595027104	PS01309 Uncharacterized protein family UPF0057 signature.
216595027105	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
216595027106	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
216595027107	inhibitor-cofactor binding pocket; inhibition site
216595027108	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595027110	PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site.
216595027111	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595027112	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595027113	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
216595027114	dimerization interface [polypeptide binding]; other site
216595027116	PS00044 Bacterial regulatory proteins, lysR family signature.
216595027118	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
216595027119	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
216595027120	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
216595027121	active site
216595027122	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
216595027123	PS00216 Sugar transport proteins signature 1.
216595027126	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
216595027127	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
216595027128	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
216595027129	FAD binding site [chemical binding]; other site
216595027130	substrate binding site [chemical binding]; other site
216595027131	catalytic residues [active]
216595027132	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
216595027133	PS00216 Sugar transport proteins signature 1.
216595027136	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
216595027137	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216595027138	metal binding site [ion binding]; metal-binding site
216595027139	active site
216595027140	I-site; other site
216595027142	PS00017 ATP/GTP-binding site motif A (P-loop).
216595027143	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
216595027144	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
216595027145	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
216595027146	active site
216595027147	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
216595027148	PS00216 Sugar transport proteins signature 1.
216595027151	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
216595027152	AAA domain; Region: AAA_26; pfam13500
216595027154	PS00017 ATP/GTP-binding site motif A (P-loop).
216595027155	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
216595027156	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595027157	S-adenosylmethionine binding site [chemical binding]; other site
216595027158	PS00639 Eukaryotic thiol (cysteine) proteases histidine active site.
216595027160	pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738
216595027162	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
216595027163	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
216595027164	substrate-cofactor binding pocket; other site
216595027165	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595027166	catalytic residue [active]
216595027168	PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site.
216595027169	biotin synthase; Provisional; Region: PRK15108
216595027170	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216595027171	FeS/SAM binding site; other site
216595027172	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
216595027175	DNA utilization protein GntX; Provisional; Region: PRK11595
216595027176	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
216595027177	active site
216595027179	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
216595027180	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
216595027181	molybdenum-pterin binding domain; Region: Mop; TIGR00638
216595027185	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
216595027186	Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318
216595027188	possible TAT system recognition site
216595027189	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
216595027190	serine/threonine protein kinase; Provisional; Region: PRK11768
216595027192	Predicted permeases [General function prediction only]; Region: RarD; COG2962
216595027193	9 probable transmembrane helices predicted for PFLU5621 by TMHMM2.0 at aa 10-31, 38-57, 72-94, 103-125, 145-167, 174-196, 211-230, 237-259 and 269-291
216595027195	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
216595027196	ACT domain; Region: ACT_6; pfam13740
216595027197	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869
216595027200	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
216595027201	active site
216595027203	PS00589 PTS HPR component serine phosphorylation site signature.
216595027204	Response regulator receiver domain; Region: Response_reg; pfam00072
216595027205	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595027206	active site
216595027207	phosphorylation site [posttranslational modification]
216595027208	intermolecular recognition site; other site
216595027209	dimerization interface [polypeptide binding]; other site
216595027211	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
216595027212	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
216595027213	ligand binding site [chemical binding]; other site
216595027214	flexible hinge region; other site
216595027215	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
216595027216	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
216595027217	metal binding triad; other site
216595027218	PS00017 ATP/GTP-binding site motif A (P-loop).
216595027222	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
216595027223	active site
216595027224	catalytic site [active]
216595027225	substrate binding site [chemical binding]; other site
216595027227	RNA polymerase sigma factor; Reviewed; Region: PRK12523
216595027228	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
216595027229	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
216595027230	DNA binding residues [nucleotide binding]
216595027233	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
216595027234	FecR protein; Region: FecR; pfam04773
216595027235	1 probable transmembrane helix predicted for PFLU5628 by TMHMM2.0 at aa 96-118
216595027237	Secretin and TonB N terminus short domain; Region: STN; smart00965
216595027238	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
216595027239	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216595027240	N-terminal plug; other site
216595027241	ligand-binding site [chemical binding]; other site
216595027245	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
216595027246	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
216595027248	4 probable transmembrane helices predicted for PFLU5630 by TMHMM2.0 at aa 21-43, 157-179, 200-222 and 346-368
216595027252	2 probable transmembrane helices predicted for PFLU5631 by TMHMM2.0 at aa 7-29 and 39-56
216595027253	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
216595027254	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
216595027256	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595027257	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
216595027258	substrate binding pocket [chemical binding]; other site
216595027259	membrane-bound complex binding site; other site
216595027260	hinge residues; other site
216595027262	PS01039 Bacterial extracellular solute-binding proteins, family 3 signature.
216595027263	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
216595027264	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595027265	dimer interface [polypeptide binding]; other site
216595027266	conserved gate region; other site
216595027267	putative PBP binding loops; other site
216595027268	ABC-ATPase subunit interface; other site
216595027269	3 probable transmembrane helices predicted for PFLU5634 by TMHMM2.0 at aa 15-46, 97-119 and 203-225
216595027271	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595027272	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595027273	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595027274	dimer interface [polypeptide binding]; other site
216595027275	conserved gate region; other site
216595027276	putative PBP binding loops; other site
216595027277	ABC-ATPase subunit interface; other site
216595027279	5 probable transmembrane helices predicted for PFLU5635 by TMHMM2.0 at aa 29-51, 64-86, 96-118, 159-181 and 201-220
216595027280	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595027281	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
216595027282	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
216595027283	Walker A/P-loop; other site
216595027284	ATP binding site [chemical binding]; other site
216595027285	Q-loop/lid; other site
216595027286	ABC transporter signature motif; other site
216595027287	Walker B; other site
216595027288	D-loop; other site
216595027289	H-loop/switch region; other site
216595027291	PS00017 ATP/GTP-binding site motif A (P-loop).
216595027292	PS00211 ABC transporters family signature.
216595027293	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
216595027294	YheO-like PAS domain; Region: PAS_6; pfam08348
216595027295	HTH domain; Region: HTH_22; pfam13309
216595027297	putative glutathione S-transferase; Provisional; Region: PRK10357
216595027298	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
216595027299	putative C-terminal domain interface [polypeptide binding]; other site
216595027300	putative GSH binding site (G-site) [chemical binding]; other site
216595027301	putative dimer interface [polypeptide binding]; other site
216595027302	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
216595027303	dimer interface [polypeptide binding]; other site
216595027304	N-terminal domain interface [polypeptide binding]; other site
216595027305	putative substrate binding pocket (H-site) [chemical binding]; other site
216595027308	inner membrane protein; Provisional; Region: PRK11715
216595027310	sensory histidine kinase CreC; Provisional; Region: PRK11100
216595027311	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595027312	dimer interface [polypeptide binding]; other site
216595027313	phosphorylation site [posttranslational modification]
216595027314	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595027315	ATP binding site [chemical binding]; other site
216595027316	Mg2+ binding site [ion binding]; other site
216595027317	G-X-G motif; other site
216595027321	DNA-binding response regulator CreB; Provisional; Region: PRK11083
216595027322	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595027323	active site
216595027324	phosphorylation site [posttranslational modification]
216595027325	intermolecular recognition site; other site
216595027326	dimerization interface [polypeptide binding]; other site
216595027327	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216595027328	DNA binding site [nucleotide binding]
216595027331	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
216595027333	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
216595027334	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
216595027335	putative acyl-acceptor binding pocket; other site
216595027336	1 probable transmembrane helix predicted for PFLU5643 by TMHMM2.0 at aa 7-29
216595027338	Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075
216595027339	1 probable transmembrane helix predicted for PFLU5644 by TMHMM2.0 at aa 34-56
216595027340	Anti-sigma-K factor rskA; Region: RskA; pfam10099
216595027341	1 probable transmembrane helix predicted for PFLU5645 by TMHMM2.0 at aa 31-50
216595027342	gcgggnnnncccgc
216595027343	formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819
216595027344	Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282
216595027345	NAD binding site [chemical binding]; other site
216595027346	catalytic Zn binding site [ion binding]; other site
216595027347	structural Zn binding site [ion binding]; other site
216595027350	PS00059 Zinc-containing alcohol dehydrogenases signature.
216595027351	formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011
216595027352	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
216595027353	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
216595027354	putative active site [active]
216595027355	putative substrate binding site [chemical binding]; other site
216595027356	putative cosubstrate binding site; other site
216595027357	catalytic site [active]
216595027359	Sarcosine oxidase, gamma subunit family; Region: SoxG; pfam04268
216595027361	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
216595027362	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
216595027363	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
216595027366	Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311
216595027368	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
216595027369	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
216595027371	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
216595027372	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
216595027373	dimer interface [polypeptide binding]; other site
216595027374	active site
216595027375	glycine-pyridoxal phosphate binding site [chemical binding]; other site
216595027376	folate binding site [chemical binding]; other site
216595027378	PS00096 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site.
216595027379	TraX protein; Region: TraX; pfam05857
216595027381	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
216595027382	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
216595027383	tetramer interface [polypeptide binding]; other site
216595027384	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595027385	catalytic residue [active]
216595027387	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
216595027389	Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457
216595027390	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
216595027391	Na binding site [ion binding]; other site
216595027393	12 probable transmembrane helices predicted for PFLU5657 by TMHMM2.0 at aa 41-63, 68-90, 111-133, 148-167, 174-196, 206-228, 249-271, 286-308, 335-357, 362-380, 401-423 and 433-455
216595027394	Predicted amidohydrolase [General function prediction only]; Region: COG0388
216595027395	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_2; cd07580
216595027396	putative active site [active]
216595027397	catalytic triad [active]
216595027398	putative dimer interface [polypeptide binding]; other site
216595027400	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
216595027401	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
216595027402	FAD binding pocket [chemical binding]; other site
216595027403	FAD binding motif [chemical binding]; other site
216595027404	phosphate binding motif [ion binding]; other site
216595027405	beta-alpha-beta structure motif; other site
216595027406	NAD binding pocket [chemical binding]; other site
216595027407	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
216595027408	catalytic loop [active]
216595027409	iron binding site [ion binding]; other site
216595027411	PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature.
216595027414	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
216595027415	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
216595027416	[2Fe-2S] cluster binding site [ion binding]; other site
216595027417	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
216595027418	putative alpha subunit interface [polypeptide binding]; other site
216595027419	putative active site [active]
216595027420	putative substrate binding site [chemical binding]; other site
216595027421	Fe binding site [ion binding]; other site
216595027423	PS00290 Immunoglobulins and major histocompatibility complex proteins signature.
216595027424	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
216595027425	Ligand Binding Site [chemical binding]; other site
216595027426	Electron transfer flavoprotein domain; Region: ETF; pfam01012
216595027428	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985
216595027429	Ligand binding site [chemical binding]; other site
216595027430	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
216595027431	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
216595027434	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2.
216595027435	Domain of unknown function (DUF3483); Region: DUF3483; pfam11982
216595027436	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
216595027437	Cysteine-rich domain; Region: CCG; pfam02754
216595027438	Cysteine-rich domain; Region: CCG; pfam02754
216595027440	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
216595027442	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
216595027443	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
216595027444	Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734
216595027445	putative active site [active]
216595027446	putative FMN binding site [chemical binding]; other site
216595027447	putative substrate binding site [chemical binding]; other site
216595027448	putative catalytic residue [active]
216595027449	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
216595027452	V4R domain; Region: V4R; cl15268
216595027453	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
216595027454	Membrane dipeptidase (Peptidase family M19); Region: Peptidase_M19; pfam01244
216595027455	active site
216595027457	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
216595027459	HipA N-terminal domain; Region: Couple_hipA; pfam13657
216595027460	HipA-like N-terminal domain; Region: HipA_N; pfam07805
216595027461	HipA-like C-terminal domain; Region: HipA_C; pfam07804
216595027464	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
216595027465	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216595027466	non-specific DNA binding site [nucleotide binding]; other site
216595027467	salt bridge; other site
216595027468	sequence-specific DNA binding site [nucleotide binding]; other site
216595027469	Protein of unknown function (DUF3010); Region: DUF3010; pfam11215
216595027470	Archaeal ATPase; Region: Arch_ATPase; pfam01637
216595027471	PS00017 ATP/GTP-binding site motif A (P-loop).
216595027472	PS00017 ATP/GTP-binding site motif A (P-loop).
216595027473	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
216595027474	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
216595027475	conserved cys residue [active]
216595027476	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595027479	1 probable transmembrane helix predicted for PFLU5672 by TMHMM2.0 at aa 16-33
216595027480	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
216595027481	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
216595027483	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
216595027485	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066
216595027486	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
216595027487	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
216595027490	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
216595027491	active site
216595027492	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
216595027493	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
216595027494	conserved cys residue [active]
216595027495	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595027497	PS00041 Bacterial regulatory proteins, araC family signature.
216595027500	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595027501	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
216595027502	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
216595027503	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
216595027506	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
216595027507	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
216595027509	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595027510	dimer interface [polypeptide binding]; other site
216595027511	conserved gate region; other site
216595027512	putative PBP binding loops; other site
216595027513	ABC-ATPase subunit interface; other site
216595027514	6 probable transmembrane helices predicted for PFLU5681 by TMHMM2.0 at aa 42-64, 69-88, 95-117, 141-163, 210-232 and 247-266
216595027516	choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415
216595027517	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216595027518	Walker A/P-loop; other site
216595027519	ATP binding site [chemical binding]; other site
216595027520	Q-loop/lid; other site
216595027521	ABC transporter signature motif; other site
216595027522	Walker B; other site
216595027523	D-loop; other site
216595027524	H-loop/switch region; other site
216595027526	PS00017 ATP/GTP-binding site motif A (P-loop).
216595027527	PS00211 ABC transporters family signature.
216595027528	BCCT family transporter; Region: BCCT; cl00569
216595027530	PS00017 ATP/GTP-binding site motif A (P-loop).
216595027531	transcriptional regulator BetI; Validated; Region: PRK00767
216595027532	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216595027533	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
216595027535	PS01081 Bacterial regulatory proteins, tetR family signature.
216595027536	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
216595027537	NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090
216595027538	tetrameric interface [polypeptide binding]; other site
216595027539	NAD binding site [chemical binding]; other site
216595027540	catalytic residues [active]
216595027542	PS00687 Aldehyde dehydrogenases glutamic acid active site.
216595027543	PS00070 Aldehyde dehydrogenases cysteine active site.
216595027544	choline dehydrogenase; Validated; Region: PRK02106
216595027545	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
216595027547	PS00623 GMC oxidoreductases signature 1.
216595027548	PS00624 GMC oxidoreductases signature 2.
216595027550	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
216595027552	PS00237 G-protein coupled receptors signature.
216595027553	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
216595027554	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
216595027556	putative transporter; Provisional; Region: PRK10504
216595027557	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595027558	putative substrate translocation pore; other site
216595027559	14 probable transmembrane helices predicted for PFLU5690 by TMHMM2.0 at aa 17-39, 54-73, 80-102, 106-128, 135-157, 167-189, 202-219, 229-251, 272-294, 304-326, 333-352, 362-384, 397-419 and 434-456
216595027561	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
216595027562	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
216595027563	ATP binding site [chemical binding]; other site
216595027564	Mg++ binding site [ion binding]; other site
216595027565	motif III; other site
216595027566	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
216595027567	nucleotide binding region [chemical binding]; other site
216595027568	ATP-binding site [chemical binding]; other site
216595027569	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
216595027570	putative RNA binding site [nucleotide binding]; other site
216595027572	PS00017 ATP/GTP-binding site motif A (P-loop).
216595027573	PS00039 DEAD-box subfamily ATP-dependent helicases signature.
216595027576	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
216595027577	HI0933-like protein; Region: HI0933_like; pfam03486
216595027579	integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667
216595027580	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
216595027581	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
216595027583	10 probable transmembrane helices predicted for PFLU5693 by TMHMM2.0 at aa 21-38, 42-59, 66-88, 93-112, 117-134, 149-171, 396-418, 465-484, 491-510 and 520-539
216595027584	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595027585	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
216595027586	substrate binding pocket [chemical binding]; other site
216595027587	membrane-bound complex binding site; other site
216595027588	hinge residues; other site
216595027589	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
216595027590	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216595027591	Coenzyme A binding pocket [chemical binding]; other site
216595027593	Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; pfam09904
216595027594	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
216595027596	Response regulator receiver domain; Region: Response_reg; pfam00072
216595027597	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595027598	active site
216595027599	phosphorylation site [posttranslational modification]
216595027600	intermolecular recognition site; other site
216595027601	dimerization interface [polypeptide binding]; other site
216595027602	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595027603	PAS domain; Region: PAS_9; pfam13426
216595027604	putative active site [active]
216595027605	heme pocket [chemical binding]; other site
216595027606	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
216595027607	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216595027608	metal binding site [ion binding]; metal-binding site
216595027609	active site
216595027610	I-site; other site
216595027611	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
216595027616	1 probable transmembrane helix predicted for PFLU5700 by TMHMM2.0 at aa 13-35
216595027617	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
216595027618	intersubunit interface [polypeptide binding]; other site
216595027619	active site
216595027620	zinc binding site [ion binding]; other site
216595027621	Na+ binding site [ion binding]; other site
216595027623	PS00806 Fructose-bisphosphate aldolase class-II signature 2.
216595027624	PS00602 Fructose-bisphosphate aldolase class-II signature 1.
216595027625	lysozyme inhibitor; Provisional; Region: PRK11372
216595027626	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
216595027627	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595027628	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595027629	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
216595027630	Phosphoglycerate kinase; Region: PGK; pfam00162
216595027631	substrate binding site [chemical binding]; other site
216595027632	hinge regions; other site
216595027633	ADP binding site [chemical binding]; other site
216595027634	catalytic site [active]
216595027636	PS00017 ATP/GTP-binding site motif A (P-loop).
216595027637	PS00111 Phosphoglycerate kinase signature.
216595027638	erythrose-4-phosphate dehydrogenase; Region: E4PD_g-proteo; TIGR01532
216595027639	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
216595027640	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
216595027643	gcgggnnnncccgc
216595027644	gcgggnnnncccgc
216595027645	gcgggnnnncccgc
216595027646	gcgggnnnncccgc
216595027647	transketolase; Reviewed; Region: PRK12753
216595027648	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
216595027649	TPP-binding site [chemical binding]; other site
216595027650	dimer interface [polypeptide binding]; other site
216595027651	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
216595027652	PYR/PP interface [polypeptide binding]; other site
216595027653	dimer interface [polypeptide binding]; other site
216595027654	TPP binding site [chemical binding]; other site
216595027655	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
216595027658	PS00802 Transketolase signature 2.
216595027660	PS00801 Transketolase signature 1.
216595027661	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
216595027662	putative DNA binding site [nucleotide binding]; other site
216595027663	dimerization interface [polypeptide binding]; other site
216595027664	putative Zn2+ binding site [ion binding]; other site
216595027665	Methyltransferase domain; Region: Methyltransf_31; pfam13847
216595027666	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595027667	S-adenosylmethionine binding site [chemical binding]; other site
216595027670	S-adenosylmethionine synthetase; Validated; Region: PRK05250
216595027671	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
216595027672	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
216595027673	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
216595027676	PS00376 S-adenosylmethionine synthetase signature 1.
216595027678	PS00377 S-adenosylmethionine synthetase signature 2.
216595027679	1 probable transmembrane helix predicted for PFLU5710 by TMHMM2.0 at aa 21-43
216595027680	NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097
216595027681	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
216595027682	nucleotide binding pocket [chemical binding]; other site
216595027683	K-X-D-G motif; other site
216595027684	catalytic site [active]
216595027685	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
216595027686	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595027689	Protein of unknown function (DUF1090); Region: DUF1090; pfam06476
216595027691	Cytochrome C' Region: Cytochrom_C_2; pfam01322
216595027693	PS00190 Cytochrome c family heme-binding site signature.
216595027694	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595027695	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
216595027696	MltA specific insert domain; Region: MltA; pfam03562
216595027697	3D domain; Region: 3D; pfam06725
216595027698	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595027699	PS00225 Crystallins beta and gamma 'Greek key' motif signature.
216595027702	Predicted membrane protein [Function unknown]; Region: COG3686
216595027703	PS00430 TonB-dependent receptor proteins signature 1.
216595027704	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
216595027705	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
216595027707	12 probable transmembrane helices predicted for PFLU5716 by TMHMM2.0 at aa 20-42, 69-86, 98-120, 130-152, 165-187, 202-224, 231-248, 252-274, 295-314, 319-341, 354-376 and 381-400
216595027708	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
216595027709	PS00017 ATP/GTP-binding site motif A (P-loop).
216595027710	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
216595027711	active site
216595027712	nucleophile elbow; other site
216595027714	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
216595027716	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
216595027717	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
216595027718	homotetramer interface [polypeptide binding]; other site
216595027719	ligand binding site [chemical binding]; other site
216595027720	catalytic site [active]
216595027721	NAD binding site [chemical binding]; other site
216595027723	PS00738 S-adenosyl-L-homocysteine hydrolase signature 1.
216595027725	PS00739 S-adenosyl-L-homocysteine hydrolase signature 2.
216595027726	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
216595027727	FAD binding site [chemical binding]; other site
216595027729	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
216595027730	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595027731	substrate binding pocket [chemical binding]; other site
216595027732	membrane-bound complex binding site; other site
216595027733	hinge residues; other site
216595027734	helicase 45; Provisional; Region: PTZ00424
216595027735	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
216595027736	ATP binding site [chemical binding]; other site
216595027737	Mg++ binding site [ion binding]; other site
216595027738	motif III; other site
216595027739	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
216595027740	nucleotide binding region [chemical binding]; other site
216595027741	ATP-binding site [chemical binding]; other site
216595027743	PS00017 ATP/GTP-binding site motif A (P-loop).
216595027744	PS00039 DEAD-box subfamily ATP-dependent helicases signature.
216595027746	hypothetical protein; Provisional; Region: PRK03757
216595027748	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
216595027750	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK07030
216595027751	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
216595027752	inhibitor-cofactor binding pocket; inhibition site
216595027753	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595027754	catalytic residue [active]
216595027756	PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site.
216595027757	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
216595027758	RNA methyltransferase, RsmE family; Region: TIGR00046
216595027760	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595027761	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
216595027762	substrate binding pocket [chemical binding]; other site
216595027763	membrane-bound complex binding site; other site
216595027764	hinge residues; other site
216595027766	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
216595027767	homotrimer interaction site [polypeptide binding]; other site
216595027768	putative active site [active]
216595027770	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
216595027771	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
216595027772	hydroxyglutarate oxidase; Provisional; Region: PRK11728
216595027774	1 probable transmembrane helix predicted for PFLU5731 by TMHMM2.0 at aa 7-26
216595027775	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
216595027776	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595027777	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
216595027778	dimerization interface [polypeptide binding]; other site
216595027781	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
216595027782	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
216595027784	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595027785	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595027786	The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416
216595027787	putative dimerization interface [polypeptide binding]; other site
216595027789	PS00044 Bacterial regulatory proteins, lysR family signature.
216595027791	malonate transporter, MadM subunit; Region: malonate_madM; TIGR00808
216595027793	Malonate transporter MadL subunit; Region: MadL; cl04273
216595027795	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595027796	malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131
216595027797	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
216595027799	phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293
216595027800	Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620
216595027801	Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; pfam06833
216595027803	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189
216595027804	malonate decarboxylase subunit delta; Provisional; Region: PRK01220
216595027806	triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237
216595027808	malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110
216595027809	PS00017 ATP/GTP-binding site motif A (P-loop).
216595027810	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
216595027812	pilus (type IV secretion system) biosynthesis gene cluster
216595027813	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
216595027814	putative binding surface; other site
216595027815	active site
216595027816	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
216595027817	putative binding surface; other site
216595027818	active site
216595027819	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
216595027820	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
216595027821	putative binding surface; other site
216595027822	active site
216595027823	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
216595027824	putative binding surface; other site
216595027825	active site
216595027826	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
216595027827	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595027828	ATP binding site [chemical binding]; other site
216595027829	Mg2+ binding site [ion binding]; other site
216595027830	G-X-G motif; other site
216595027831	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
216595027832	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595027833	Response regulator receiver domain; Region: Response_reg; pfam00072
216595027834	active site
216595027835	phosphorylation site [posttranslational modification]
216595027836	intermolecular recognition site; other site
216595027837	dimerization interface [polypeptide binding]; other site
216595027847	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
216595027848	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
216595027849	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595027850	dimer interface [polypeptide binding]; other site
216595027851	putative CheW interface [polypeptide binding]; other site
216595027853	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
216595027855	Response regulator receiver domain; Region: Response_reg; pfam00072
216595027856	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595027857	active site
216595027858	phosphorylation site [posttranslational modification]
216595027859	intermolecular recognition site; other site
216595027860	dimerization interface [polypeptide binding]; other site
216595027862	Response regulator receiver domain; Region: Response_reg; pfam00072
216595027863	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595027864	active site
216595027865	phosphorylation site [posttranslational modification]
216595027866	intermolecular recognition site; other site
216595027867	dimerization interface [polypeptide binding]; other site
216595027869	glutathione synthetase; Provisional; Region: PRK05246
216595027870	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
216595027871	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
216595027874	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
216595027875	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
216595027876	1 probable transmembrane helix predicted for PFLU5754 by TMHMM2.0 at aa 22-44
216595027877	hypothetical protein; Validated; Region: PRK00228
216595027879	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
216595027881	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
216595027882	active site
216595027884	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
216595027885	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
216595027886	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
216595027888	PS00097 Aspartate and ornithine carbamoyltransferases signature.
216595027890	dihydroorotase; Validated; Region: pyrC; PRK09357
216595027891	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
216595027892	active site
216595027894	TM2 domain; Region: TM2; cl00984
216595027895	TM2 domain; Region: TM2; cl00984
216595027898	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
216595027899	NlpC/P60 family; Region: NLPC_P60; pfam00877
216595027901	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
216595027902	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
216595027903	Walker A motif; other site
216595027904	ATP binding site [chemical binding]; other site
216595027905	Walker B motif; other site
216595027907	PS00662 Bacterial type II secretion system protein E signature.
216595027908	PS00017 ATP/GTP-binding site motif A (P-loop).
216595027909	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
216595027910	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
216595027911	catalytic residue [active]
216595027913	PS01211 Uncharacterized protein family UPF0001 signature.
216595027914	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
216595027915	pyrroline-5-carboxylate reductase; Region: PLN02688
216595027917	PS00521 Delta 1-pyrroline-5-carboxylate reductase signature.
216595027918	YGGT family; Region: YGGT; pfam02325
216595027919	YGGT family; Region: YGGT; pfam02325
216595027920	4 probable transmembrane helices predicted for PFLU5765 by TMHMM2.0 at aa 7-29, 69-91, 98-120 and 162-184
216595027923	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
216595027924	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
216595027926	Methyltransferase domain; Region: Methyltransf_23; pfam13489
216595027927	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595027928	S-adenosylmethionine binding site [chemical binding]; other site
216595027930	Domain of unknown function (DUF4426); Region: DUF4426; pfam14467
216595027931	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
216595027932	active site
216595027933	dimerization interface [polypeptide binding]; other site
216595027935	HemN family oxidoreductase; Provisional; Region: PRK05660
216595027936	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
216595027937	FeS/SAM binding site; other site
216595027938	HemN C-terminal domain; Region: HemN_C; pfam06969
216595027941	Protein of unknown function (DUF3392); Region: DUF3392; pfam11872
216595027942	3 probable transmembrane helices predicted for PFLU5771 by TMHMM2.0 at aa 20-42, 55-77 and 87-104
216595027943	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595027944	S-adenosylmethionine binding site [chemical binding]; other site
216595027946	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
216595027947	ThiS interaction site; other site
216595027948	putative active site [active]
216595027949	tetramer interface [polypeptide binding]; other site
216595027951	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
216595027952	thiS-thiF/thiG interaction site; other site
216595027954	Protein of unknown function (DUF423); Region: DUF423; pfam04241
216595027956	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
216595027957	Transglycosylase; Region: Transgly; cl17702
216595027958	1 probable transmembrane helix predicted for PFLU5776 by TMHMM2.0 at aa 9-31
216595027960	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
216595027961	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
216595027962	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
216595027963	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
216595027964	DNA binding residues [nucleotide binding]
216595027966	PS00716 Sigma-70 factors family signature 2.
216595027968	PS00715 Sigma-70 factors family signature 1.
216595027969	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
216595027970	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
216595027972	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
216595027973	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216595027974	Walker A/P-loop; other site
216595027975	ATP binding site [chemical binding]; other site
216595027976	Q-loop/lid; other site
216595027977	ABC transporter signature motif; other site
216595027978	Walker B; other site
216595027979	D-loop; other site
216595027980	H-loop/switch region; other site
216595027982	PS00017 ATP/GTP-binding site motif A (P-loop).
216595027983	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
216595027984	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
216595027985	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
216595027986	P loop; other site
216595027987	GTP binding site [chemical binding]; other site
216595027989	PS00300 SRP54-type proteins GTP-binding domain signature.
216595027990	PS00017 ATP/GTP-binding site motif A (P-loop).
216595027992	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
216595027993	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
216595027994	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
216595027997	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
216595027998	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
216595027999	1 probable transmembrane helix predicted for PFLU5783 by TMHMM2.0 at aa 9-28
216595028002	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
216595028003	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595028004	S-adenosylmethionine binding site [chemical binding]; other site
216595028006	PS00092 N-6 Adenine-specific DNA methylases signature.
216595028007	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
216595028009	PS01133 Uncharacterized protein family UPF0017 signature.
216595028010	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
216595028011	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
216595028012	active site residue [active]
216595028013	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
216595028014	active site residue [active]
216595028016	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595028017	PS00215 Mitochondrial energy transfer proteins signature.
216595028019	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
216595028020	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216595028021	Bacterial transcriptional repressor; Region: TetR; pfam13972
216595028023	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
216595028024	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
216595028025	NAD(P) binding site [chemical binding]; other site
216595028026	catalytic residues [active]
216595028028	PS00211 ABC transporters family signature.
216595028029	PS00687 Aldehyde dehydrogenases glutamic acid active site.
216595028030	PS00070 Aldehyde dehydrogenases cysteine active site.
216595028031	GMC oxidoreductase; Region: GMC_oxred_N; pfam00732
216595028032	dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970
216595028033	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
216595028037	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
216595028038	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
216595028039	active site
216595028040	(T/H)XGH motif; other site
216595028042	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
216595028044	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature.
216595028045	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
216595028046	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
216595028047	DNA binding site [nucleotide binding]
216595028048	catalytic residue [active]
216595028049	H2TH interface [polypeptide binding]; other site
216595028050	putative catalytic residues [active]
216595028051	turnover-facilitating residue; other site
216595028052	intercalation triad [nucleotide binding]; other site
216595028053	8OG recognition residue [nucleotide binding]; other site
216595028054	putative reading head residues; other site
216595028055	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
216595028056	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
216595028059	Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639
216595028060	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
216595028061	Zn2+ binding site [ion binding]; other site
216595028062	Mg2+ binding site [ion binding]; other site
216595028064	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
216595028065	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
216595028066	putative RNA binding site [nucleotide binding]; other site
216595028067	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595028068	S-adenosylmethionine binding site [chemical binding]; other site
216595028070	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
216595028071	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595028072	putative substrate translocation pore; other site
216595028073	11 probable transmembrane helices predicted for PFLU5796 by TMHMM2.0 at aa 12-34, 49-71, 78-100, 105-124, 136-158, 168-190, 211-233, 248-270, 282-304, 338-360 and 367-389
216595028075	PS00216 Sugar transport proteins signature 1.
216595028076	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
216595028078	PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1.
216595028079	PS00017 ATP/GTP-binding site motif A (P-loop).
216595028080	PS00887 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 2.
216595028081	Secretin and TonB N terminus short domain; Region: STN; smart00965
216595028082	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
216595028083	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216595028084	N-terminal plug; other site
216595028085	ligand-binding site [chemical binding]; other site
216595028089	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595028090	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
216595028091	FecR protein; Region: FecR; pfam04773
216595028093	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
216595028094	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
216595028095	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
216595028096	DNA binding residues [nucleotide binding]
216595028099	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
216595028100	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
216595028101	10 probable transmembrane helices predicted for PFLU5802 by TMHMM2.0 at aa 5-20, 33-51, 71-93, 105-127, 186-205, 232-254, 264-286, 333-355, 370-392 and 399-421
216595028103	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
216595028104	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
216595028105	folate binding site [chemical binding]; other site
216595028106	NADP+ binding site [chemical binding]; other site
216595028108	PS00075 Dihydrofolate reductase signature.
216595028109	Protein of unknown function (DUF2868); Region: DUF2868; pfam11067
216595028110	5 probable transmembrane helices predicted for PFLU5804 by TMHMM2.0 at aa 72-94, 104-126, 174-196, 211-233 and 254-276
216595028111	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
216595028112	G1 box; other site
216595028113	GTP/Mg2+ binding site [chemical binding]; other site
216595028114	G2 box; other site
216595028115	Switch I region; other site
216595028116	G3 box; other site
216595028117	Switch II region; other site
216595028118	G4 box; other site
216595028119	Domain of unknown function (DUF3482); Region: DUF3482; pfam11981
216595028120	G5 box; other site
216595028122	PS00017 ATP/GTP-binding site motif A (P-loop).
216595028123	phosphonate degradation operons associated HDIG domain protein; Region: Phn-HD; TIGR03276
216595028125	FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed
216595028127	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
216595028128	putative 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate-binding protein; Region: phnS2; TIGR03261
216595028130	putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262
216595028131	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595028132	dimer interface [polypeptide binding]; other site
216595028133	conserved gate region; other site
216595028134	putative PBP binding loops; other site
216595028135	ABC-ATPase subunit interface; other site
216595028136	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595028137	dimer interface [polypeptide binding]; other site
216595028138	conserved gate region; other site
216595028139	putative PBP binding loops; other site
216595028140	ABC-ATPase subunit interface; other site
216595028143	putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265
216595028144	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216595028145	Walker A/P-loop; other site
216595028146	ATP binding site [chemical binding]; other site
216595028147	Q-loop/lid; other site
216595028148	ABC transporter signature motif; other site
216595028149	Walker B; other site
216595028150	D-loop; other site
216595028151	H-loop/switch region; other site
216595028152	TOBE domain; Region: TOBE_2; pfam08402
216595028155	PS00211 ABC transporters family signature.
216595028156	PS00017 ATP/GTP-binding site motif A (P-loop).
216595028157	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
216595028158	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595028159	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
216595028160	dimerization interface [polypeptide binding]; other site
216595028163	PS00044 Bacterial regulatory proteins, lysR family signature.
216595028164	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
216595028165	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
216595028166	metal-binding site [ion binding]
216595028167	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
216595028168	Soluble P-type ATPase [General function prediction only]; Region: COG4087
216595028170	PS01229 Hypothetical cof family signature 2.
216595028171	PS00017 ATP/GTP-binding site motif A (P-loop).
216595028172	PS00154 E1-E2 ATPases phosphorylation site.
216595028174	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
216595028175	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
216595028176	DNA binding residues [nucleotide binding]
216595028177	dimer interface [polypeptide binding]; other site
216595028178	putative metal binding site [ion binding]; other site
216595028181	thymidylate synthase; Reviewed; Region: thyA; PRK01827
216595028182	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
216595028183	dimerization interface [polypeptide binding]; other site
216595028184	active site
216595028186	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
216595028188	PS01311 Prolipoprotein diacylglyceryl transferase signature.
216595028189	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
216595028191	NRDE protein; Region: NRDE; cl01315
216595028193	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
216595028194	GAF domain; Region: GAF; pfam01590
216595028195	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
216595028196	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
216595028197	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
216595028199	PS00742 PEP-utilizing enzymes signature 2.
216595028203	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
216595028204	putative active site [active]
216595028205	Ap4A binding site [chemical binding]; other site
216595028206	nudix motif; other site
216595028207	putative metal binding site [ion binding]; other site
216595028209	PS00893 mutT domain signature.
216595028210	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
216595028211	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216595028212	motif II; other site
216595028214	Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027
216595028215	threonine dehydratase; Reviewed; Region: PRK09224
216595028216	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
216595028217	tetramer interface [polypeptide binding]; other site
216595028218	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595028219	catalytic residue [active]
216595028220	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
216595028221	putative Ile/Val binding site [chemical binding]; other site
216595028222	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
216595028223	putative Ile/Val binding site [chemical binding]; other site
216595028227	PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site.
216595028228	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
216595028229	tetramer (dimer of dimers) interface [polypeptide binding]; other site
216595028230	active site
216595028231	dimer interface [polypeptide binding]; other site
216595028233	SdiA-regulated; Region: SdiA-regulated; pfam06977
216595028234	SdiA-regulated; Region: SdiA-regulated; cd09971
216595028235	putative active site [active]
216595028237	SdiA-regulated; Region: SdiA-regulated; pfam06977
216595028238	SdiA-regulated; Region: SdiA-regulated; cd09971
216595028239	putative active site [active]
216595028241	1 probable transmembrane helix predicted for PFLU5826 by TMHMM2.0 at aa 21-40
216595028242	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
216595028243	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
216595028245	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
216595028246	FAD binding domain; Region: FAD_binding_4; pfam01565
216595028247	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
216595028250	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
216595028251	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
216595028252	ligand binding site [chemical binding]; other site
216595028253	NAD binding site [chemical binding]; other site
216595028254	tetramer interface [polypeptide binding]; other site
216595028255	catalytic site [active]
216595028256	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
216595028257	L-serine binding site [chemical binding]; other site
216595028258	ACT domain interface; other site
216595028261	PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature.
216595028262	PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2.
216595028264	Domain of unknown function (DUF4399); Region: DUF4399; pfam14347
216595028265	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595028266	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
216595028267	substrate binding pocket [chemical binding]; other site
216595028268	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
216595028269	membrane-bound complex binding site; other site
216595028270	hinge residues; other site
216595028272	PS01039 Bacterial extracellular solute-binding proteins, family 3 signature.
216595028273	Helix-turn-helix domain; Region: HTH_28; pfam13518
216595028274	Winged helix-turn helix; Region: HTH_29; pfam13551
216595028275	Homeodomain-like domain; Region: HTH_32; pfam13565
216595028276	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
216595028277	Integrase core domain; Region: rve; pfam00665
216595028278	Integrase core domain; Region: rve_3; pfam13683
216595028280	Uncharacterized conserved protein [Function unknown]; Region: COG1683
216595028282	Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702
216595028284	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
216595028285	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
216595028286	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
216595028288	1 probable transmembrane helix predicted for PFLU5837 by TMHMM2.0 at aa 7-29
216595028289	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595028290	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
216595028291	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
216595028292	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
216595028293	active site
216595028294	1 probable transmembrane helix predicted for PFLU5838 by TMHMM2.0 at aa 7-24
216595028296	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
216595028297	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
216595028298	conserved cys residue [active]
216595028299	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
216595028303	PS00017 ATP/GTP-binding site motif A (P-loop).
216595028304	HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401
216595028306	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
216595028307	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595028308	dimer interface [polypeptide binding]; other site
216595028309	conserved gate region; other site
216595028310	putative PBP binding loops; other site
216595028311	ABC-ATPase subunit interface; other site
216595028313	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595028314	PS00340 Growth factor and cytokines receptors family signature 2.
216595028315	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595028316	dimer interface [polypeptide binding]; other site
216595028317	conserved gate region; other site
216595028318	putative PBP binding loops; other site
216595028319	ABC-ATPase subunit interface; other site
216595028321	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595028322	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
216595028323	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216595028324	Walker A/P-loop; other site
216595028325	ATP binding site [chemical binding]; other site
216595028326	Q-loop/lid; other site
216595028327	ABC transporter signature motif; other site
216595028328	Walker B; other site
216595028329	D-loop; other site
216595028330	H-loop/switch region; other site
216595028331	TOBE domain; Region: TOBE_2; pfam08402
216595028334	PS00211 ABC transporters family signature.
216595028335	PS00017 ATP/GTP-binding site motif A (P-loop).
216595028336	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
216595028337	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
216595028339	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
216595028340	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
216595028342	PS00017 ATP/GTP-binding site motif A (P-loop).
216595028343	PS00017 ATP/GTP-binding site motif A (P-loop).
216595028344	putative aminotransferase; Validated; Region: PRK07480
216595028345	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
216595028346	inhibitor-cofactor binding pocket; inhibition site
216595028347	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595028348	catalytic residue [active]
216595028350	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
216595028351	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
216595028353	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
216595028354	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
216595028356	PS00181 Glutamine synthetase putative ATP-binding region signature.
216595028358	Transposase; Region: HTH_Tnp_1; pfam01527
216595028359	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
216595028361	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
216595028362	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
216595028364	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
216595028366	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
216595028367	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216595028368	Walker A/P-loop; other site
216595028369	ATP binding site [chemical binding]; other site
216595028370	Q-loop/lid; other site
216595028371	ABC transporter signature motif; other site
216595028372	Walker B; other site
216595028373	D-loop; other site
216595028374	H-loop/switch region; other site
216595028376	PS00211 ABC transporters family signature.
216595028377	PS00017 ATP/GTP-binding site motif A (P-loop).
216595028378	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
216595028379	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595028380	dimer interface [polypeptide binding]; other site
216595028381	conserved gate region; other site
216595028382	putative PBP binding loops; other site
216595028383	ABC-ATPase subunit interface; other site
216595028385	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
216595028386	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
216595028387	active site
216595028388	dimer interface [polypeptide binding]; other site
216595028389	non-prolyl cis peptide bond; other site
216595028390	insertion regions; other site
216595028392	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
216595028393	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595028394	substrate binding pocket [chemical binding]; other site
216595028395	membrane-bound complex binding site; other site
216595028396	hinge residues; other site
216595028398	1 probable transmembrane helix predicted for PFLU5857 by TMHMM2.0 at aa 7-29
216595028399	NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569
216595028400	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
216595028402	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
216595028403	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
216595028404	dimer interface [polypeptide binding]; other site
216595028405	decamer (pentamer of dimers) interface [polypeptide binding]; other site
216595028406	catalytic triad [active]
216595028408	outer membrane porin, OprD family; Region: OprD; pfam03573
216595028410	N-acetylglutamate synthase; Validated; Region: PRK05279
216595028411	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
216595028412	putative feedback inhibition sensing region; other site
216595028413	putative nucleotide binding site [chemical binding]; other site
216595028414	putative substrate binding site [chemical binding]; other site
216595028415	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216595028416	Coenzyme A binding pocket [chemical binding]; other site
216595028419	acetylornithine deacetylase; Provisional; Region: PRK05111
216595028420	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
216595028421	metal binding site [ion binding]; metal-binding site
216595028422	putative dimer interface [polypeptide binding]; other site
216595028425	Uncharacterized conserved protein [Function unknown]; Region: COG3025
216595028426	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
216595028427	putative active site [active]
216595028428	putative metal binding residues [ion binding]; other site
216595028429	signature motif; other site
216595028430	putative triphosphate binding site [ion binding]; other site
216595028432	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
216595028433	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
216595028434	putative DNA binding site [nucleotide binding]; other site
216595028435	putative Zn2+ binding site [ion binding]; other site
216595028436	AsnC family; Region: AsnC_trans_reg; pfam01037
216595028438	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
216595028439	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
216595028440	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
216595028441	Walker A motif; other site
216595028442	ATP binding site [chemical binding]; other site
216595028443	Walker B motif; other site
216595028446	PS00017 ATP/GTP-binding site motif A (P-loop).
216595028447	PS00662 Bacterial type II secretion system protein E signature.
216595028448	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
216595028449	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
216595028450	1 probable transmembrane helix predicted for PFLU5868 by TMHMM2.0 at aa 7-29
216595028452	PS00216 Sugar transport proteins signature 1.
216595028453	PS01270 Band 7 protein family signature.
216595028454	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
216595028456	2 probable transmembrane helices predicted for PFLU5869 by TMHMM2.0 at aa 13-35 and 55-73
216595028457	conserverd hypothetical protein; Region: TIGR02448
216595028458	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
216595028459	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
216595028460	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
216595028461	inhibitor-cofactor binding pocket; inhibition site
216595028462	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595028463	catalytic residue [active]
216595028465	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
216595028466	lipoyl attachment site [posttranslational modification]; other site
216595028468	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
216595028469	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
216595028471	PS00213 Lipocalin signature.
216595028473	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
216595028474	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595028475	dimer interface [polypeptide binding]; other site
216595028476	conserved gate region; other site
216595028477	putative PBP binding loops; other site
216595028478	ABC-ATPase subunit interface; other site
216595028480	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595028482	PS00095 C-5 cytosine-specific DNA methylases C-terminal signature.
216595028483	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
216595028484	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
216595028486	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
216595028487	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK05714
216595028488	PS01304 ubiH/COQ6 monooxygenase family signature.
216595028490	1 probable transmembrane helix predicted for PFLU5877 by TMHMM2.0 at aa 7-29
216595028491	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732
216595028492	2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984
216595028494	1 probable transmembrane helix predicted for PFLU5879 by TMHMM2.0 at aa 7-26
216595028495	proline aminopeptidase P II; Provisional; Region: PRK10879
216595028496	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
216595028497	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
216595028498	active site
216595028500	PS00213 Lipocalin signature.
216595028502	hypothetical protein; Reviewed; Region: PRK02166
216595028504	TIGR02449 family protein; Region: TIGR02449
216595028505	Cell division protein ZapA; Region: ZapA; pfam05164
216595028507	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
216595028509	1 probable transmembrane helix predicted for PFLU5886 by TMHMM2.0 at aa 17-39
216595028510	EVE domain; Region: EVE; cl00728
216595028512	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
216595028513	HlyD family secretion protein; Region: HlyD_3; pfam13437
216595028514	1 probable transmembrane helix predicted for PFLU5888 by TMHMM2.0 at aa 12-34
216595028516	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216595028517	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
216595028518	Walker A/P-loop; other site
216595028519	ATP binding site [chemical binding]; other site
216595028520	Q-loop/lid; other site
216595028521	ABC transporter signature motif; other site
216595028522	Walker B; other site
216595028523	D-loop; other site
216595028524	H-loop/switch region; other site
216595028525	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
216595028526	Walker A/P-loop; other site
216595028527	ATP binding site [chemical binding]; other site
216595028528	Q-loop/lid; other site
216595028529	ABC transporter signature motif; other site
216595028530	Walker B; other site
216595028531	D-loop; other site
216595028532	H-loop/switch region; other site
216595028533	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
216595028534	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
216595028536	PS00017 ATP/GTP-binding site motif A (P-loop).
216595028537	PS00211 ABC transporters family signature.
216595028539	PS00017 ATP/GTP-binding site motif A (P-loop).
216595028540	7 probable transmembrane helices predicted for PFLU5889 by TMHMM2.0 at aa 553-575, 705-727, 760-782, 789-811, 816-838, 845-867 and 877-899
216595028542	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
216595028543	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
216595028544	6 probable transmembrane helices predicted for PFLU5890 by TMHMM2.0 at aa 23-45, 177-199, 231-253, 258-280, 287-306 and 341-363
216595028546	flagellar basal body-associated protein FliL-like protein; Validated; Region: PRK05697
216595028548	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
216595028549	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
216595028550	NAD(P) binding site [chemical binding]; other site
216595028554	sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
216595028555	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595028556	putative substrate translocation pore; other site
216595028557	12 probable transmembrane helices predicted for PFLU5893 by TMHMM2.0 at aa 28-45, 65-87, 94-116, 120-142, 155-177, 187-206, 254-273, 293-312, 319-341, 351-373, 380-402 and 417-439
216595028559	PS00942 glpT family of transporters signature.
216595028560	Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703
216595028561	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
216595028562	putative active site pocket [active]
216595028563	dimerization interface [polypeptide binding]; other site
216595028564	putative catalytic residue [active]
216595028566	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
216595028567	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216595028568	N-terminal plug; other site
216595028569	ligand-binding site [chemical binding]; other site
216595028572	PS00430 TonB-dependent receptor proteins signature 1.
216595028573	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
216595028574	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
216595028575	catalytic loop [active]
216595028576	iron binding site [ion binding]; other site
216595028577	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
216595028578	FAD binding pocket [chemical binding]; other site
216595028579	FAD binding motif [chemical binding]; other site
216595028580	phosphate binding motif [ion binding]; other site
216595028581	beta-alpha-beta structure motif; other site
216595028582	NAD binding pocket [chemical binding]; other site
216595028586	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
216595028588	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
216595028590	transcription termination factor Rho; Provisional; Region: rho; PRK09376
216595028591	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
216595028592	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
216595028593	RNA binding site [nucleotide binding]; other site
216595028594	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
216595028595	multimer interface [polypeptide binding]; other site
216595028596	Walker A motif; other site
216595028597	ATP binding site [chemical binding]; other site
216595028598	Walker B motif; other site
216595028600	PS00017 ATP/GTP-binding site motif A (P-loop).
216595028603	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
216595028604	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
216595028605	catalytic residues [active]
216595028607	PS00194 Thioredoxin family active site.
216595028608	Transcriptional regulators [Transcription]; Region: FadR; COG2186
216595028609	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595028610	DNA-binding site [nucleotide binding]; DNA binding site
216595028611	FCD domain; Region: FCD; pfam07729
216595028613	PS00211 ABC transporters family signature.
216595028615	PS00043 Bacterial regulatory proteins, gntR family signature.
216595028616	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
216595028617	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
216595028618	substrate binding pocket [chemical binding]; other site
216595028619	membrane-bound complex binding site; other site
216595028620	hinge residues; other site
216595028622	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
216595028623	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595028624	dimer interface [polypeptide binding]; other site
216595028625	conserved gate region; other site
216595028626	putative PBP binding loops; other site
216595028627	ABC-ATPase subunit interface; other site
216595028629	5 probable transmembrane helices predicted for PFLU5904 by TMHMM2.0 at aa 20-42, 55-77, 87-104, 138-160 and 191-213
216595028630	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
216595028631	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595028632	dimer interface [polypeptide binding]; other site
216595028633	conserved gate region; other site
216595028634	putative PBP binding loops; other site
216595028635	ABC-ATPase subunit interface; other site
216595028637	5 probable transmembrane helices predicted for PFLU5905 by TMHMM2.0 at aa 15-37, 57-79, 83-105, 142-164 and 184-203
216595028638	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
216595028639	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
216595028640	Walker A/P-loop; other site
216595028641	ATP binding site [chemical binding]; other site
216595028642	Q-loop/lid; other site
216595028643	ABC transporter signature motif; other site
216595028644	Walker B; other site
216595028645	D-loop; other site
216595028646	H-loop/switch region; other site
216595028648	PS00017 ATP/GTP-binding site motif A (P-loop).
216595028649	PS00211 ABC transporters family signature.
216595028650	hypothetical protein; Provisional; Region: PRK15301
216595028651	putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304
216595028652	PapC N-terminal domain; Region: PapC_N; pfam13954
216595028653	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
216595028654	PapC C-terminal domain; Region: PapC_C; pfam13953
216595028655	PS00294 Prenyl group binding site (CAAX box).
216595028657	putative fimbrial chaperone protein; Provisional; Region: PRK09918
216595028658	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
216595028661	1 probable transmembrane helix predicted for PFLU5909 by TMHMM2.0 at aa 7-29
216595028662	Protein of unknown function (DUF1120); Region: DUF1120; cl05856
216595028664	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
216595028665	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
216595028667	polyphosphate kinase; Provisional; Region: PRK05443
216595028668	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
216595028669	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
216595028670	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
216595028671	putative active site [active]
216595028672	catalytic site [active]
216595028673	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
216595028674	putative domain interface [polypeptide binding]; other site
216595028675	putative active site [active]
216595028676	catalytic site [active]
216595028678	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
216595028679	dimer interface [polypeptide binding]; other site
216595028680	active site
216595028681	aspartate-rich active site metal binding site; other site
216595028682	allosteric magnesium binding site [ion binding]; other site
216595028683	Schiff base residues; other site
216595028685	PS00169 Delta-aminolevulinic acid dehydratase active site.
216595028686	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
216595028687	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
216595028688	5 probable transmembrane helices predicted for PFLU5914 by TMHMM2.0 at aa 11-33, 40-62, 93-115, 122-144 and 159-176
216595028689	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
216595028690	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
216595028691	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
216595028692	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
216595028693	conserved cys residue [active]
216595028695	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671
216595028697	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
216595028698	Cytochrome c; Region: Cytochrom_C; pfam00034
216595028699	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
216595028702	PS00190 Cytochrome c family heme-binding site signature.
216595028703	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014
216595028704	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595028706	Putative periplasmic lipoprotein; Region: DUF1425; cd09030
216595028707	putative dimer interface [polypeptide binding]; other site
216595028709	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595028710	Protein of unknown function (DUF3897); Region: DUF3897; pfam13036
216595028711	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595028712	Protein of unknown function (DUF3897); Region: DUF3897; cl17494
216595028713	LysE type translocator; Region: LysE; cl00565
216595028715	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
216595028716	Mechanosensitive ion channel; Region: MS_channel; pfam00924
216595028718	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
216595028719	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
216595028720	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
216595028721	ABC transporter; Region: ABC_tran_2; pfam12848
216595028722	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
216595028724	PS00211 ABC transporters family signature.
216595028725	PS00017 ATP/GTP-binding site motif A (P-loop).
216595028727	PS00211 ABC transporters family signature.
216595028728	PS00017 ATP/GTP-binding site motif A (P-loop).
216595028729	Protein of unknown function (DUF2390); Region: DUF2390; pfam09523
216595028730	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
216595028731	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
216595028732	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
216595028735	PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1.
216595028736	PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2.
216595028737	anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718
216595028739	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
216595028740	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
216595028741	HemY protein N-terminus; Region: HemY_N; pfam07219
216595028743	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
216595028745	PS00215 Mitochondrial energy transfer proteins signature.
216595028746	1 probable transmembrane helix predicted for PFLU5932 by TMHMM2.0 at aa 30-52
216595028747	uroporphyrinogen-III synthase; Validated; Region: PRK05752
216595028748	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
216595028749	active site
216595028751	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
216595028752	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
216595028753	domain interfaces; other site
216595028754	active site
216595028756	PS00533 Porphobilinogen deaminase cofactor-binding site.
216595028758	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
216595028759	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595028760	active site
216595028761	phosphorylation site [posttranslational modification]
216595028762	intermolecular recognition site; other site
216595028763	dimerization interface [polypeptide binding]; other site
216595028764	LytTr DNA-binding domain; Region: LytTR; pfam04397
216595028767	argininosuccinate lyase; Provisional; Region: PRK00855
216595028768	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
216595028769	active sites [active]
216595028770	tetramer interface [polypeptide binding]; other site
216595028772	PS00163 Fumarate lyases signature.
216595028773	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
216595028774	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
216595028775	C-terminal domain interface [polypeptide binding]; other site
216595028776	GSH binding site (G-site) [chemical binding]; other site
216595028777	dimer interface [polypeptide binding]; other site
216595028778	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
216595028779	N-terminal domain interface [polypeptide binding]; other site
216595028780	dimer interface [polypeptide binding]; other site
216595028781	substrate binding pocket (H-site) [chemical binding]; other site
216595028783	Phosphate-starvation-inducible E; Region: PsiE; cl01264
216595028784	adenylate cyclase; Provisional; Region: cyaA; PRK09450
216595028785	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
216595028786	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
216595028788	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
216595028789	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
216595028790	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
216595028792	frataxin-like protein; Provisional; Region: cyaY; PRK00446
216595028793	putative iron binding site [ion binding]; other site
216595028795	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361
216595028796	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595028797	diaminopimelate decarboxylase; Region: lysA; TIGR01048
216595028798	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
216595028799	active site
216595028800	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
216595028801	substrate binding site [chemical binding]; other site
216595028802	catalytic residues [active]
216595028803	dimer interface [polypeptide binding]; other site
216595028805	PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site.
216595028806	PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2.
216595028808	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
216595028809	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
216595028810	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
216595028812	PS01326 Diaminopimelate epimerase signature.
216595028813	PS00017 ATP/GTP-binding site motif A (P-loop).
216595028815	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3159
216595028817	PS00017 ATP/GTP-binding site motif A (P-loop).
216595028818	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
216595028819	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
216595028820	active site
216595028821	DNA binding site [nucleotide binding]
216595028822	Int/Topo IB signature motif; other site
216595028825	flavin mononucleotide phosphatase; Provisional; Region: PRK10748
216595028826	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
216595028827	motif II; other site
216595028829	Uncharacterized conserved protein [Function unknown]; Region: COG0432
216595028831	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
216595028833	PS01219 Ammonium transporters signature.
216595028834	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595028835	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
216595028836	Nitrogen regulatory protein P-II; Region: P-II; smart00938
216595028838	PS00638 P-II protein C-terminal region signature.
216595028839	PS00496 P-II protein urydylation site.
216595028840	Membrane fusogenic activity; Region: BMFP; pfam04380
216595028842	3 probable transmembrane helices predicted for PFLU5955 by TMHMM2.0 at aa 37-54, 61-80 and 84-106
216595028843	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
216595028844	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
216595028845	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
216595028846	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
216595028848	PS00017 ATP/GTP-binding site motif A (P-loop).
216595028849	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
216595028850	dimerization interface [polypeptide binding]; other site
216595028851	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
216595028852	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
216595028853	dimer interface [polypeptide binding]; other site
216595028854	putative CheW interface [polypeptide binding]; other site
216595028858	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
216595028859	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595028860	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
216595028861	dimerization interface [polypeptide binding]; other site
216595028864	PS00044 Bacterial regulatory proteins, lysR family signature.
216595028865	multidrug efflux protein NorA; Provisional; Region: PRK00187
216595028866	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
216595028867	cation binding site [ion binding]; other site
216595028868	12 probable transmembrane helices predicted for PFLU5959 by TMHMM2.0 at aa 9-31, 51-73, 93-110, 125-147, 160-179, 189-211, 239-261, 271-293, 313-335, 350-372, 393-415 and 419-441
216595028871	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
216595028872	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216595028873	metal binding site [ion binding]; metal-binding site
216595028874	active site
216595028875	I-site; other site
216595028876	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
216595028879	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
216595028880	Part of AAA domain; Region: AAA_19; pfam13245
216595028881	Family description; Region: UvrD_C_2; pfam13538
216595028883	PS00017 ATP/GTP-binding site motif A (P-loop).
216595028884	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
216595028885	active site
216595028888	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
216595028889	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
216595028890	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
216595028891	PS00190 Cytochrome c family heme-binding site signature.
216595028892	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
216595028893	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
216595028894	non-specific DNA binding site [nucleotide binding]; other site
216595028895	salt bridge; other site
216595028896	sequence-specific DNA binding site [nucleotide binding]; other site
216595028897	Cupin domain; Region: Cupin_2; pfam07883
216595028900	alanine racemase; Reviewed; Region: dadX; PRK03646
216595028901	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
216595028902	active site
216595028903	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
216595028904	substrate binding site [chemical binding]; other site
216595028905	catalytic residues [active]
216595028906	dimer interface [polypeptide binding]; other site
216595028909	PS00395 Alanine racemase pyridoxal-phosphate attachment site.
216595028910	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
216595028911	homotrimer interaction site [polypeptide binding]; other site
216595028912	putative active site [active]
216595028914	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
216595028915	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
216595028917	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595028918	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
216595028919	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
216595028920	putative DNA binding site [nucleotide binding]; other site
216595028921	putative Zn2+ binding site [ion binding]; other site
216595028922	AsnC family; Region: AsnC_trans_reg; pfam01037
216595028923	PS00519 Bacterial regulatory proteins, asnC family signature.
216595028925	Flagellin N-methylase; Region: FliB; pfam03692
216595028927	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
216595028928	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
216595028930	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
216595028931	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595028932	DNA-binding site [nucleotide binding]; DNA binding site
216595028933	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216595028934	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595028935	homodimer interface [polypeptide binding]; other site
216595028936	catalytic residue [active]
216595028939	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
216595028940	PLD-like domain; Region: PLDc_2; pfam13091
216595028941	putative active site [active]
216595028942	catalytic site [active]
216595028943	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
216595028944	PLD-like domain; Region: PLDc_2; pfam13091
216595028945	putative active site [active]
216595028946	catalytic site [active]
216595028947	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595028950	enterobactin exporter EntS; Provisional; Region: PRK10489
216595028952	gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847
216595028953	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
216595028954	NAD(P) binding site [chemical binding]; other site
216595028955	catalytic residues [active]
216595028957	PS00070 Aldehyde dehydrogenases cysteine active site.
216595028958	PS00687 Aldehyde dehydrogenases glutamic acid active site.
216595028959	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595028960	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
216595028962	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
216595028964	PS00228 Tubulin-beta mRNA autoregulation signal.
216595028965	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
216595028967	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
216595028968	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
216595028969	peptide binding site [polypeptide binding]; other site
216595028971	hypothetical protein; Reviewed; Region: PRK00024
216595028972	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
216595028973	MPN+ (JAMM) motif; other site
216595028974	Zinc-binding site [ion binding]; other site
216595028976	PS01302 DNA repair protein radC family signature.
216595028977	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
216595028978	Flavoprotein; Region: Flavoprotein; pfam02441
216595028979	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
216595028981	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595028983	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
216595028984	trimer interface [polypeptide binding]; other site
216595028985	active site
216595028987	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
216595028988	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
216595028989	active site
216595028990	substrate binding site [chemical binding]; other site
216595028991	metal binding site [ion binding]; metal-binding site
216595028993	PS00017 ATP/GTP-binding site motif A (P-loop).
216595028994	PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature.
216595028998	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
216595028999	feedback inhibition sensing region; other site
216595029000	homohexameric interface [polypeptide binding]; other site
216595029001	nucleotide binding site [chemical binding]; other site
216595029002	N-acetyl-L-glutamate binding site [chemical binding]; other site
216595029004	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
216595029005	active site
216595029007	PS00103 Purine/pyrimidine phosphoribosyl transferases signature.
216595029008	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
216595029009	putative active site [active]
216595029010	putative catalytic site [active]
216595029011	putative DNA binding site [nucleotide binding]; other site
216595029012	putative phosphate binding site [ion binding]; other site
216595029013	metal binding site A [ion binding]; metal-binding site
216595029014	putative AP binding site [nucleotide binding]; other site
216595029015	putative metal binding site B [ion binding]; other site
216595029017	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296
216595029018	ribonuclease PH; Reviewed; Region: rph; PRK00173
216595029019	Ribonuclease PH; Region: RNase_PH_bact; cd11362
216595029020	hexamer interface [polypeptide binding]; other site
216595029021	active site
216595029024	PS01277 Ribonuclease PH signature.
216595029025	hypothetical protein; Provisional; Region: PRK11820
216595029026	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
216595029027	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
216595029030	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
216595029031	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
216595029032	catalytic site [active]
216595029033	G-X2-G-X-G-K; other site
216595029034	PS00017 ATP/GTP-binding site motif A (P-loop).
216595029035	PS00856 Guanylate kinase signature.
216595029037	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
216595029039	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
216595029040	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
216595029041	Zn2+ binding site [ion binding]; other site
216595029042	Mg2+ binding site [ion binding]; other site
216595029043	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
216595029044	synthetase active site [active]
216595029045	NTP binding site [chemical binding]; other site
216595029046	metal binding site [ion binding]; metal-binding site
216595029047	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
216595029048	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
216595029052	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
216595029053	homotrimer interaction site [polypeptide binding]; other site
216595029054	putative active site [active]
216595029056	PS01094 Uncharacterized protein family UPF0076 signature.
216595029057	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595029059	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
216595029060	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
216595029061	putative NAD(P) binding site [chemical binding]; other site
216595029063	tonB-system energizer ExbB; Region: exbB; TIGR02797
216595029064	4 probable transmembrane helices predicted for PFLU5999 by TMHMM2.0 at aa 20-39, 104-126, 212-234 and 258-280
216595029066	biopolymer transport protein ExbD; Provisional; Region: PRK11267
216595029067	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
216595029069	1 probable transmembrane helix predicted for PFLU6000 by TMHMM2.0 at aa 20-42
216595029070	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
216595029071	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
216595029072	1 probable transmembrane helix predicted for PFLU6001 by TMHMM2.0 at aa 13-35
216595029073	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
216595029074	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595029075	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
216595029076	dimerization interface [polypeptide binding]; other site
216595029078	PS00044 Bacterial regulatory proteins, lysR family signature.
216595029080	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
216595029081	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
216595029082	generic binding surface II; other site
216595029083	ssDNA binding site; other site
216595029084	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
216595029085	ATP binding site [chemical binding]; other site
216595029086	putative Mg++ binding site [ion binding]; other site
216595029087	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
216595029088	nucleotide binding region [chemical binding]; other site
216595029089	ATP-binding site [chemical binding]; other site
216595029092	PS00017 ATP/GTP-binding site motif A (P-loop).
216595029094	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
216595029095	putative deacylase active site [active]
216595029096	Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639
216595029099	PS00024 Hemopexin domain signature.
216595029101	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
216595029104	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
216595029105	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216595029106	Walker A/P-loop; other site
216595029107	ATP binding site [chemical binding]; other site
216595029108	Q-loop/lid; other site
216595029109	ABC transporter signature motif; other site
216595029110	Walker B; other site
216595029111	D-loop; other site
216595029112	H-loop/switch region; other site
216595029114	PS00017 ATP/GTP-binding site motif A (P-loop).
216595029115	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
216595029116	Catalytic domain of Protein Kinases; Region: PKc; cd00180
216595029117	active site
216595029118	ATP binding site [chemical binding]; other site
216595029119	substrate binding site [chemical binding]; other site
216595029120	activation loop (A-loop); other site
216595029121	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
216595029122	metal ion-dependent adhesion site (MIDAS); other site
216595029123	1 probable transmembrane helix predicted for PFLU6010 by TMHMM2.0 at aa 325-347
216595029125	PS00108 Serine/Threonine protein kinases active-site signature.
216595029126	PS00107 Protein kinases ATP-binding region signature.
216595029127	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
216595029128	Protein phosphatase 2C; Region: PP2C; pfam00481
216595029129	active site
216595029131	Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867
216595029132	type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348
216595029133	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
216595029134	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
216595029137	PS00017 ATP/GTP-binding site motif A (P-loop).
216595029138	hypothetical protein; Provisional; Region: PRK07033
216595029139	Type VI protein secretion system component VasF [Intracellular    trafficking, secretion, and vesicular transport]; Region: COG3455
216595029140	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
216595029141	ligand binding site [chemical binding]; other site
216595029143	1 probable transmembrane helix predicted for PFLU6014 by TMHMM2.0 at aa 223-245
216595029144	PS00017 ATP/GTP-binding site motif A (P-loop).
216595029145	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3522
216595029146	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
216595029148	type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352
216595029149	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595029150	type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354
216595029151	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
216595029152	phosphopeptide binding site; other site
216595029154	type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363
216595029155	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
216595029157	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3516
216595029159	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517
216595029160	Protein of unknown function (DUF877); Region: DUF877; pfam05943
216595029162	Protein of unknown function (DUF796); Region: DUF796; pfam05638
216595029164	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3518
216595029166	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
216595029167	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
216595029169	Protein of unknown function (DUF1305); Region: DUF1305; pfam06996
216595029171	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
216595029172	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595029173	Walker A motif; other site
216595029174	ATP binding site [chemical binding]; other site
216595029175	Walker B motif; other site
216595029176	arginine finger; other site
216595029177	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
216595029178	Walker A motif; other site
216595029179	ATP binding site [chemical binding]; other site
216595029180	Walker B motif; other site
216595029181	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
216595029184	PS00017 ATP/GTP-binding site motif A (P-loop).
216595029185	PS00870 Chaperonins clpA/B signature 1.
216595029187	PS00017 ATP/GTP-binding site motif A (P-loop).
216595029188	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
216595029189	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
216595029190	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
216595029192	Domain of unknown function (DUF1795); Region: DUF1795; pfam08786
216595029194	PAAR motif; Region: PAAR_motif; pfam05488
216595029195	RHS Repeat; Region: RHS_repeat; cl11982
216595029196	RHS Repeat; Region: RHS_repeat; pfam05593
216595029197	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
216595029198	RHS Repeat; Region: RHS_repeat; pfam05593
216595029199	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
216595029200	RHS protein; Region: RHS; pfam03527
216595029201	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
216595029202	RES domain; Region: RES; smart00953
216595029203	2 probable transmembrane helices predicted for PFLU6028 by TMHMM2.0 at aa 24-46 and 53-75
216595029220	PAAR motif; Region: PAAR_motif; pfam05488
216595029221	RHS Repeat; Region: RHS_repeat; cl11982
216595029222	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
216595029223	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
216595029224	RHS Repeat; Region: RHS_repeat; pfam05593
216595029225	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
216595029226	RHS Repeat; Region: RHS_repeat; pfam05593
216595029227	RHS Repeat; Region: RHS_repeat; pfam05593
216595029228	RHS Repeat; Region: RHS_repeat; cl11982
216595029229	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
216595029230	RHS Repeat; Region: RHS_repeat; cl11982
216595029231	RHS protein; Region: RHS; pfam03527
216595029232	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
216595029234	2 probable transmembrane helices predicted for PFLU6030 by TMHMM2.0 at aa 26-48 and 55-77
216595029250	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
216595029251	Sel1-like repeats; Region: SEL1; smart00671
216595029253	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
216595029254	IHF - DNA interface [nucleotide binding]; other site
216595029255	IHF dimer interface [polypeptide binding]; other site
216595029257	PS00045 Bacterial histone-like DNA-binding proteins signature.
216595029258	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
216595029259	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
216595029260	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
216595029263	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595029264	Rubredoxin [Energy production and conversion]; Region: COG1773
216595029265	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
216595029266	iron binding site [ion binding]; other site
216595029268	PS00202 Rubredoxin signature.
216595029269	Chorismate lyase; Region: Chor_lyase; cl01230
216595029271	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
216595029272	UbiA prenyltransferase family; Region: UbiA; pfam01040
216595029273	7 probable transmembrane helices predicted for PFLU6036 by TMHMM2.0 at aa 29-46, 51-73, 102-124, 144-166, 173-195, 241-263 and 276-295
216595029275	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
216595029276	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4315
216595029279	1 probable transmembrane helix predicted for PFLU6037 by TMHMM2.0 at aa 37-59
216595029280	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
216595029281	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595029282	active site
216595029283	phosphorylation site [posttranslational modification]
216595029284	intermolecular recognition site; other site
216595029285	dimerization interface [polypeptide binding]; other site
216595029286	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
216595029287	DNA binding site [nucleotide binding]
216595029290	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
216595029291	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
216595029292	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595029293	putative active site [active]
216595029294	heme pocket [chemical binding]; other site
216595029295	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
216595029296	dimer interface [polypeptide binding]; other site
216595029297	phosphorylation site [posttranslational modification]
216595029298	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
216595029299	ATP binding site [chemical binding]; other site
216595029300	Mg2+ binding site [ion binding]; other site
216595029301	G-X-G motif; other site
216595029302	1 probable transmembrane helix predicted for PFLU6040 by TMHMM2.0 at aa 21-43
216595029306	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
216595029307	Domain of unknown function DUF21; Region: DUF21; pfam01595
216595029308	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
216595029309	Transporter associated domain; Region: CorC_HlyC; smart01091
216595029310	4 probable transmembrane helices predicted for PFLU6041 by TMHMM2.0 at aa 36-58, 95-117, 137-159 and 172-194
216595029312	PS00192 Cytochrome b/b6 heme-ligand signature.
216595029315	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
216595029316	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
216595029317	Peptidase family M23; Region: Peptidase_M23; pfam01551
216595029319	Response regulator receiver domain; Region: Response_reg; pfam00072
216595029320	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
216595029321	active site
216595029322	phosphorylation site [posttranslational modification]
216595029323	intermolecular recognition site; other site
216595029324	dimerization interface [polypeptide binding]; other site
216595029326	transcriptional regulator PhoU; Provisional; Region: PRK11115
216595029327	PhoU domain; Region: PhoU; pfam01895
216595029328	PhoU domain; Region: PhoU; pfam01895
216595029331	phosphate transporter ATP-binding protein; Provisional; Region: PRK14236
216595029332	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
216595029333	Walker A/P-loop; other site
216595029334	ATP binding site [chemical binding]; other site
216595029335	Q-loop/lid; other site
216595029336	ABC transporter signature motif; other site
216595029337	Walker B; other site
216595029338	D-loop; other site
216595029339	H-loop/switch region; other site
216595029341	PS00211 ABC transporters family signature.
216595029342	PS00017 ATP/GTP-binding site motif A (P-loop).
216595029343	ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985
216595029344	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
216595029345	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595029346	dimer interface [polypeptide binding]; other site
216595029347	conserved gate region; other site
216595029348	putative PBP binding loops; other site
216595029349	ABC-ATPase subunit interface; other site
216595029351	PS00402 Binding-protein-dependent transport systems inner membrane comp. sign.
216595029352	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590
216595029353	The Sema domain, a protein interacting module, of semaphorins and plexins; Region: Sema; cl15693
216595029354	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
216595029355	dimer interface [polypeptide binding]; other site
216595029356	conserved gate region; other site
216595029357	putative PBP binding loops; other site
216595029358	ABC-ATPase subunit interface; other site
216595029360	PBP superfamily domain; Region: PBP_like_2; cl17296
216595029361	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
216595029362	metabolite-proton symporter; Region: 2A0106; TIGR00883
216595029363	putative substrate translocation pore; other site
216595029365	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
216595029366	PS00213 Lipocalin signature.
216595029368	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
216595029369	active site
216595029370	phosphate binding residues; other site
216595029371	catalytic residues [active]
216595029373	Protein of unknown function (DUF3299); Region: DUF3299; pfam11736
216595029374	Predicted membrane protein [Function unknown]; Region: COG2261
216595029376	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
216595029377	ATP-grasp domain; Region: ATP-grasp; pfam02222
216595029379	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
216595029382	cell density-dependent motility repressor; Provisional; Region: PRK10082
216595029383	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595029384	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
216595029385	dimerization interface [polypeptide binding]; other site
216595029387	PS00435 Peroxidases proximal heme-ligand signature.
216595029389	PS00044 Bacterial regulatory proteins, lysR family signature.
216595029390	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
216595029391	Aspartase; Region: Aspartase; cd01357
216595029392	active sites [active]
216595029393	tetramer interface [polypeptide binding]; other site
216595029395	PS00163 Fumarate lyases signature.
216595029396	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
216595029397	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
216595029398	10 probable transmembrane helices predicted for PFLU6058 by TMHMM2.0 at aa 26-45, 90-112, 156-178, 193-212, 219-241, 256-275, 310-332, 357-379, 400-419 and 423-440
216595029400	PS00873 Sodium:alanine symporter family signature.
216595029401	PS00225 Crystallins beta and gamma 'Greek key' motif signature.
216595029402	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
216595029403	active site
216595029404	homodimer interface [polypeptide binding]; other site
216595029406	PS00144 Asparaginase / glutaminase active site signature 1.
216595029407	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
216595029408	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
216595029410	Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001
216595029411	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
216595029412	active site
216595029413	Zn binding site [ion binding]; other site
216595029415	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
216595029416	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
216595029418	PS00017 ATP/GTP-binding site motif A (P-loop).
216595029419	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
216595029420	DNA-binding site [nucleotide binding]; DNA binding site
216595029421	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
216595029422	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
216595029423	pyridoxal 5'-phosphate binding site [chemical binding]; other site
216595029424	homodimer interface [polypeptide binding]; other site
216595029425	catalytic residue [active]
216595029427	PS00626 Regulator of chromosome condensation (RCC1) signature 2.
216595029429	PS00043 Bacterial regulatory proteins, gntR family signature.
216595029430	Putative FMN-binding domain; Region: FMN_bind_2; pfam04299
216595029432	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
216595029433	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
216595029434	Coenzyme A binding pocket [chemical binding]; other site
216595029436	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
216595029437	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
216595029438	PS00019 Actinin-type actin-binding domain signature 1.
216595029442	pyruvate carboxylase subunit B; Validated; Region: PRK09282
216595029443	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
216595029444	active site
216595029445	catalytic residues [active]
216595029446	metal binding site [ion binding]; metal-binding site
216595029447	homodimer binding site [polypeptide binding]; other site
216595029448	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
216595029449	carboxyltransferase (CT) interaction site; other site
216595029450	biotinylation site [posttranslational modification]; other site
216595029454	PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site.
216595029455	pyruvate carboxylase subunit A; Validated; Region: PRK07178
216595029456	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
216595029457	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
216595029458	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
216595029461	PS00867 Carbamoyl-phosphate synthase subdomain signature 2.
216595029462	PS00866 Carbamoyl-phosphate synthase subdomain signature 1.
216595029464	Transcriptional regulator [Transcription]; Region: LysR; COG0583
216595029465	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
216595029466	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
216595029467	putative dimerization interface [polypeptide binding]; other site
216595029469	PS00044 Bacterial regulatory proteins, lysR family signature.
216595029471	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
216595029472	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
216595029473	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
216595029474	putative active site [active]
216595029477	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595029478	PAS fold; Region: PAS_3; pfam08447
216595029479	putative active site [active]
216595029480	heme pocket [chemical binding]; other site
216595029481	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
216595029482	PAS domain; Region: PAS_9; pfam13426
216595029483	putative active site [active]
216595029484	heme pocket [chemical binding]; other site
216595029485	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
216595029486	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
216595029487	metal binding site [ion binding]; metal-binding site
216595029488	active site
216595029489	I-site; other site
216595029490	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
216595029495	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
216595029496	Part of AAA domain; Region: AAA_19; pfam13245
216595029497	Family description; Region: UvrD_C_2; pfam13538
216595029499	PS00017 ATP/GTP-binding site motif A (P-loop).
216595029500	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395
216595029501	2 probable transmembrane helices predicted for PFLU6076 by TMHMM2.0 at aa 74-96 and 101-120
216595029503	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
216595029504	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
216595029506	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
216595029508	PS00017 ATP/GTP-binding site motif A (P-loop).
216595029509	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595029510	pyridoxamine kinase; Validated; Region: PRK05756
216595029511	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
216595029512	pyridoxal binding site [chemical binding]; other site
216595029513	dimer interface [polypeptide binding]; other site
216595029514	ATP binding site [chemical binding]; other site
216595029515	Protein of unknown function (DUF3301); Region: DUF3301; pfam11743
216595029516	1 probable transmembrane helix predicted for PFLU6082 by TMHMM2.0 at aa 4-26
216595029517	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
216595029518	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
216595029519	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
216595029522	PS00017 ATP/GTP-binding site motif A (P-loop).
216595029523	Protein of unknown function (DUF1826); Region: DUF1826; pfam08856
216595029525	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
216595029526	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
216595029527	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
216595029530	PS00017 ATP/GTP-binding site motif A (P-loop).
216595029531	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
216595029533	AMIN domain; Region: AMIN; pfam11741
216595029534	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
216595029535	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
216595029536	active site
216595029537	metal binding site [ion binding]; metal-binding site
216595029539	putative GTP cyclohydrolase; Provisional; Region: PRK13674
216595029541	ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559
216595029542	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
216595029543	Walker A/P-loop; other site
216595029544	ATP binding site [chemical binding]; other site
216595029545	Q-loop/lid; other site
216595029546	ABC transporter signature motif; other site
216595029547	Walker B; other site
216595029548	D-loop; other site
216595029549	H-loop/switch region; other site
216595029551	PS00017 ATP/GTP-binding site motif A (P-loop).
216595029552	PS00211 ABC transporters family signature.
216595029553	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
216595029554	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
216595029555	ABC-ATPase subunit  interface; other site
216595029556	dimer interface [polypeptide binding]; other site
216595029557	putative PBP binding regions; other site
216595029559	8 probable transmembrane helices predicted for PFLU6090 by TMHMM2.0 at aa 15-37, 44-66, 71-90, 102-121, 143-165, 186-208, 228-250 and 257-279
216595029560	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
216595029561	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
216595029562	metal binding site [ion binding]; metal-binding site
216595029564	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
216595029566	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
216595029567	Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710
216595029568	trimer interface [polypeptide binding]; other site
216595029569	active site
216595029574	dihydroorotase; Reviewed; Region: PRK09236
216595029575	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
216595029576	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
216595029577	active site
216595029578	PS00483 Dihydroorotase signature 2.
216595029580	Protein of unknown function (DUF3617); Region: DUF3617; pfam12276
216595029581	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
216595029582	Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155
216595029583	putative active site [active]
216595029584	catalytic site [active]
216595029585	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
216595029586	putative active site [active]
216595029587	catalytic site [active]
216595029588	2 probable transmembrane helices predicted for PFLU6096 by TMHMM2.0 at aa 15-37 and 44-66
216595029591	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
216595029592	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595029593	S-adenosylmethionine binding site [chemical binding]; other site
216595029595	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
216595029596	hypothetical protein; Provisional; Region: PRK05409
216595029598	Predicted integral membrane protein (DUF2282); Region: DUF2282; cl02366
216595029599	PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
216595029600	1 probable transmembrane helix predicted for PFLU6100 by TMHMM2.0 at aa 7-29
216595029601	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
216595029602	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
216595029604	PS00154 E1-E2 ATPases phosphorylation site.
216595029606	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
216595029607	HflK protein; Region: hflK; TIGR01933
216595029609	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
216595029610	HflC protein; Region: hflC; TIGR01932
216595029612	1 probable transmembrane helix predicted for PFLU6103 by TMHMM2.0 at aa 32-51
216595029613	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
216595029614	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
216595029615	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
216595029616	4 probable transmembrane helices predicted for PFLU6105 by TMHMM2.0 at aa 34-56, 112-134, 154-171 and 176-193
216595029618	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
216595029619	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
216595029620	Putative methyltransferase; Region: Methyltransf_20; pfam12147
216595029622	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
216595029623	active site
216595029624	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
216595029625	active site
216595029626	catalytic residues [active]
216595029627	7 probable transmembrane helices predicted for PFLU6107 by TMHMM2.0 at aa 9-31, 51-73, 86-105, 128-147, 154-176, 186-208 and 221-243
216595029630	2 probable transmembrane helices predicted for PFLU6108 by TMHMM2.0 at aa 39-61 and 123-145
216595029631	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
216595029632	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
216595029633	putative acyl-acceptor binding pocket; other site
216595029635	Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589
216595029636	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
216595029637	9 probable transmembrane helices predicted for PFLU6110 by TMHMM2.0 at aa 15-37, 57-90, 105-122, 127-149, 164-186, 191-213, 233-250, 257-279 and 299-321
216595029639	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506
216595029640	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
216595029641	MG2 domain; Region: A2M_N; pfam01835
216595029642	Alpha-2-macroglobulin family; Region: A2M; pfam00207
216595029643	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
216595029644	1 probable transmembrane helix predicted for PFLU6111 by TMHMM2.0 at aa 54-76
216595029647	penicillin-binding protein 1C; Region: PBP_1c; TIGR02073
216595029648	Transglycosylase; Region: Transgly; pfam00912
216595029649	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
216595029650	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
216595029654	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
216595029655	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
216595029656	glutaminase active site [active]
216595029657	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
216595029658	dimer interface [polypeptide binding]; other site
216595029659	active site
216595029660	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
216595029661	dimer interface [polypeptide binding]; other site
216595029662	active site
216595029666	PS00443 Glutamine amidotransferases class-II active site.
216595029667	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
216595029668	putative DNA binding site [nucleotide binding]; other site
216595029669	DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434
216595029670	putative Zn2+ binding site [ion binding]; other site
216595029671	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
216595029674	PS00894 Bacterial regulatory proteins, deoR family signature.
216595029676	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
216595029677	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
216595029678	Substrate binding site; other site
216595029679	Mg++ binding site; other site
216595029680	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
216595029681	active site
216595029682	substrate binding site [chemical binding]; other site
216595029683	CoA binding site [chemical binding]; other site
216595029693	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
216595029694	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
216595029695	gamma subunit interface [polypeptide binding]; other site
216595029696	epsilon subunit interface [polypeptide binding]; other site
216595029697	LBP interface [polypeptide binding]; other site
216595029699	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
216595029700	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
216595029701	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
216595029702	alpha subunit interaction interface [polypeptide binding]; other site
216595029703	Walker A motif; other site
216595029704	ATP binding site [chemical binding]; other site
216595029705	Walker B motif; other site
216595029706	inhibitor binding site; inhibition site
216595029707	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
216595029710	PS00152 ATP synthase alpha and beta subunits signature.
216595029711	PS00017 ATP/GTP-binding site motif A (P-loop).
216595029713	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
216595029714	core domain interface [polypeptide binding]; other site
216595029715	delta subunit interface [polypeptide binding]; other site
216595029716	epsilon subunit interface [polypeptide binding]; other site
216595029718	PS00153 ATP synthase gamma subunit signature.
216595029719	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
216595029720	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
216595029721	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
216595029722	beta subunit interaction interface [polypeptide binding]; other site
216595029723	Walker A motif; other site
216595029724	ATP binding site [chemical binding]; other site
216595029725	Walker B motif; other site
216595029726	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
216595029729	PS00152 ATP synthase alpha and beta subunits signature.
216595029730	PS00017 ATP/GTP-binding site motif A (P-loop).
216595029732	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
216595029733	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
216595029735	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
216595029736	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
216595029738	1 probable transmembrane helix predicted for PFLU6122 by TMHMM2.0 at aa 12-34
216595029739	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
216595029741	PS00605 ATP synthase c subunit signature.
216595029742	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
216595029743	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
216595029745	PS00449 ATP synthase a subunit signature.
216595029746	F0F1 ATP synthase subunit I; Validated; Region: PRK05760
216595029748	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
216595029749	ParB-like nuclease domain; Region: ParBc; pfam02195
216595029751	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
216595029752	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
216595029753	P-loop; other site
216595029754	Magnesium ion binding site [ion binding]; other site
216595029755	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
216595029756	Magnesium ion binding site [ion binding]; other site
216595029758	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
216595029759	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
216595029760	S-adenosylmethionine binding site [chemical binding]; other site
216595029762	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
216595029763	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
216595029764	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
216595029765	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
216595029767	PS01281 Glucose inhibited division protein A family signature 2.
216595029768	PS01280 Glucose inhibited division protein A family signature 1.
216595029769	PS00017 ATP/GTP-binding site motif A (P-loop).
216595029770	low G+C content region (42.88%)
216595029771	RNA polymerase sigma factor; Provisional; Region: PRK12528
216595029772	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
216595029773	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
216595029774	DNA binding residues [nucleotide binding]
216595029777	fec operon regulator FecR; Reviewed; Region: PRK09774
216595029778	FecR protein; Region: FecR; pfam04773
216595029780	Secretin and TonB N terminus short domain; Region: STN; smart00965
216595029781	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
216595029782	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
216595029783	N-terminal plug; other site
216595029784	ligand-binding site [chemical binding]; other site
216595029788	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
216595029789	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
216595029790	trmE is a tRNA modification GTPase; Region: trmE; cd04164
216595029791	G1 box; other site
216595029792	GTP/Mg2+ binding site [chemical binding]; other site
216595029793	Switch I region; other site
216595029794	G2 box; other site
216595029795	Switch II region; other site
216595029796	G3 box; other site
216595029797	G4 box; other site
216595029798	G5 box; other site
216595029799	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
216595029801	PS00017 ATP/GTP-binding site motif A (P-loop).
216595029802	membrane protein insertase; Provisional; Region: PRK01318
216595029803	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
216595029805	ribonuclease P; Reviewed; Region: rnpA; PRK00396
216595029807	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
216595029809	PS00784 Ribosomal protein L34 signature.