-- dump date 20111121_014123 -- class Genbank::CDS -- table cds_note -- id note YP_001201752.1 no significant database hits YP_001201756.1 no significant database hits YP_001201757.1 no significant database hits YP_001201758.1 no significant database hits YP_001201759.1 no significant database hits YP_001201761.1 no significant database hits YP_001201762.1 no significant database hits YP_001201767.1 Codons 55 to the C-terminus are similar to Shewanella sp. ANA-3 hypothetical protein. UniProt:Q36FQ9_9GAMM (146 aa) fasta scores: E()=0.48, 27.536% id in 138 aa YP_001201768.1 no significant database hits YP_001201769.1 no significant database hits YP_001201770.1 no significant database hits YP_001201771.1 no significant database hits YP_001201772.1 no significant database hits YP_001201773.1 no significant database hits YP_001201774.1 no significant database hits YP_001201775.2 N-terminus to codon 200 is similar to codons 435 to 625 of Streptococcus criceti paaA SWALL:Q9LBG3 (EMBL:AB042239) (1653 aa) fasta scores: E()=0.45, id=30.09% id in 206 aa, and to Streptococcus criceti paaA. UniProt:Q9LBG3 (EMBL:AB042239) (1653 aa) fasta scores: E()=0.24, 30.097% id in 206 aa YP_001201777.1 no significant database hits YP_001201778.1 no significant database hits YP_001201779.1 no significant database hits YP_001201780.1 Codons 148 to 560 are similar to codons 175 to the C-terminus of Aeromonas hydrophila type IV pilus assembly protein TapB SWALL:TAPB_AERHY (SWALL:P45792) (568 aa) fasta scores: E(): 7.1e-37, 36.56% id in 413 aa, and Codons 148 to 560 are similar to codons 172 to the C-terminus of Aquifex aeolicus type IV pilus assembly protein TapB or aq_1971 SWALL:O67782 (EMBL:AE000766) (566 aa) fasta scores: E(): 8.1e-43, 39.27% id in 415 aa YP_001201782.1 Similar to C-terminus of Vibrio cholerae general secretion pathway protein F EpsF or vc2731 SWALL:GSPF_VIBCH (SWALL:P45780) (406 aa) fasta scores: E()=0.0038, id=23.39% id in 295 aa, and to entire protein of Thermotoga maritima general secretion pathway protein f, putative tm0094 SWALL:Q9WXU9 (EMBL:AE001696) (399 aa) fasta scores: E()=0.00054, id=22.48% id in 338 aa YP_001201783.1 This CDS overlaps 17 nt with the downstream CDS; N-terminus is similar to Acinetobacter sp. BD413 comp SWALL:O30583 (EMBL:AF012550) (147 aa) fasta scores: E()=0.064, id=31.03% id in 116 aa, and to Pseudomonas aeruginosa PilA SWALL:Q93PL5 (EMBL:AF331071) (154 aa) fasta scores: E()=0.11, id=30.87% id in 149 aa YP_001201784.1 N-terminus is similar to Chromobacterium violaceum general secretion pathway protein g hofg or cv3811 SWALL:Q7NRH0 (EMBL:AE016923) (147 aa) fasta scores: E()=0.0042, id=36.14% id in 83 aa, and N-terminus is similar to Burkholderia ambifaria AMMD general secretion pathway protein g precursor. UniProt:Q3FDY7_9BURK (231 aa) fasta scores: E()=0.0036, 38.462% id in 91 aa YP_001201786.1 Similar, although truncated at the N-terminus, to Methanosarcina mazei transcriptional regulator mm3284 SWALL:Q8PS04 (EMBL:AE013588) (379 aa) fasta scores: E()=4e-11, id=24.02% id in 383 aa; This CDS overlaps 4 nt at the C-terminus with pQBR0045 YP_001201787.1 This CDS overlaps 4 nt at the N-terminus with pQBR0044 YP_001201788.1 no significant database hits YP_001201789.1 no significant database hits YP_001201790.1 This CDS overlaps 8 nt at the C-terminus with pQBR0049 YP_001201791.1 N-terminus to codon 370 is similar to N-terminus to codon 375 of Solibacter usitatus Ellin6076 radical sam. UniProt:Q43TZ7_SOLUS (391 aa) fasta scores: E()=0.012, 21.951% id in 369 aa. This CDS overlaps 8 nt at the N-terminus with pQBR0048 YP_001201793.1 no significant database hits YP_001201795.1 Similar to C-terminus of Sphingopyxis alaskensis RB2256 radical sam. UniProt:Q3VFX6_9SPHN (608 aa) fasta scores: E()=4.9e-06, 25.275% id in 364 aa YP_001201796.1 no significant database hits YP_001201801.1 Similar to the C-terminus of Agrobacterium tumefaciens GGDEF family protein atu3207 or agr_l_3210 SWALL:Q8UB10 (EMBL:AE009250) (668 aa) fasta scores: E()=1.3e-16, id=30.08% id in 236 aa YP_001201806.1 no significant database hits YP_001201807.1 no significant database hits YP_001201808.1 no significant database hits YP_001201809.1 no significant database hits YP_001201811.1 no significant database hits YP_001201813.1 N-terminus is similar to Nitrosococcus oceani (strain ATCC 19707/NCIMB 11848) endonuclease/exonuclease/phosphatase precursor. UniProt:Q3JF75_NITOC (398 aa) fasta scores: E()=9e-33, 41.667% id in 276 aa YP_001201814.1 no significant database hits YP_001201816.1 no significant database hits YP_001201817.1 This CDS may be transcribed together with pQBR0076 and form part of a pseudogene, alternatively the CDSs may be transcribed separately YP_001201818.1 Similar to C-terminus from codon 155 of Burkholderia vietnamiensis G4 hypothetical protein. UniProt:Q4BN10_BURVI (272 aa) fasta scores: E()=1.7e-05, 28.947% id in 114 aa. This CDS may be transcribed as part of a pseudogene with pQBR0075, or alternatively be a separate CDS YP_001201819.1 no significant database hits YP_001201820.1 no significant database hits YP_001201822.1 Similar to Pseudomonas syringae pv. phaseolicola (strain 1448A/Race 6) uvrd/rep helicase family protein. UniProt:Q48IC3_PSE14 (830 aa) fasta scores: E()=2e-86, 33.960% id in 798 aa, and to fragment of Pseudomonas fluorescens helc putative helicase (fragment). UniProt:Q708B8 (EMBL:AJ617291) (184 aa) fasta scores: E()=4.5e-62, 98.324% id in 179 aa YP_001201825.1 no significant database hits YP_001201836.1 no significant database hits YP_001201838.1 no significant database hits; C-terminus is similar to Burkholderia pseudomallei (Pseudomonas pseudomallei) hypothetical protein. UniProt:Q63NA4_BURPS (165 aa) fasta scores: E()=0.00065, 29.197% id in 137 aa YP_001201839.1 no significant database hits YP_001201840.1 no significant database hits YP_001201842.1 no significant database hits YP_001201843.1 no significant database hits YP_001201844.1 no significant database hits; Similar to Shewanella sp. ANA-3 hypothetical protein. UniProt:Q36EN8_9GAMM (316 aa) fasta scores: E()=4.7e-13, 38.971% id in 136 aa YP_001201845.1 C-terminus is similar to the N-terminus of Pseudomonas putida hypothetical protein SWALL:Q8VMP7 (EMBL:AJ344068) (244 aa) fasta scores: E()=2.3e-05, id=28.15% id in 206 aa, and to Pseudomonas putida hypothetical protein. UniProt:Q8VMP7_PSEPU (244 aa) fasta scores: E()=7.1e-05, 28.155% id in 206 aa YP_001201846.1 no significant database hits YP_001201850.1 no significant database hits YP_001201854.1 no significant database hits YP_001201855.1 no significant database hits YP_001201859.1 no significant database hits YP_001201860.1 no significant database hits YP_001201863.1 no significant database hits YP_001201864.1 no significant database hits YP_001201866.1 no significant database hits YP_001201868.1 no significant database hits YP_001201869.1 no significant database hits YP_001201872.1 no significant database hits YP_001201873.1 Similar to C-terminus of Pseudomonas aeruginosa tola protein tola or pa0971 SWALL:TOLA_PSEAE (SWALL:P50600) (347 aa) fasta scores: E()=2e-08, id=33.01% id in 206 aa, and similar to the C-terminus of Azotobacter vinelandii AvOP tonb, c-terminal precursor. UniProt:Q4IT56_AZOVI (452 aa) fasta scores: E()=1.4e-09, 29.101% id in 189 aa YP_001201874.1 no significant database hits YP_001201877.1 no significant database hits YP_001201878.1 Similar to C-terminus of Pseudomonas syringae thiol:disulfide interchange protein dsbd or pspto4858 SWALL:Q87VS7 (EMBL:AE016873) (604 aa) fasta scores: E()=2.5e-08, id=27.11% id in 236 aa YP_001201879.1 no signficant database hits YP_001201881.1 From codon 175 similar to Pseudomonas syringae autotransporter, putative pspto0714 SWALL:Q889N5 (EMBL:AE016858) (763 aa) fasta scores: E()=1e-72, id=40.65% id in 738 aa, and to Pseudomonas syringae pv. syringae (strain B728a) outer membrane autotransporter barrel precursor. UniProt:Q4ZYT2_PSEU2 (759 aa) fasta scores: E()=4.6e-70, 41.411% id in 751 aa YP_001201882.1 no significant database hits YP_001201883.1 no significant database hits YP_001201884.1 no significant database hits YP_001201885.1 no significant database hits YP_001201886.1 no significant database hits YP_001201887.1 no significant database hits YP_001201889.1 no significant database hits YP_001201890.1 no significant database hits YP_001201891.1 no significant database hits YP_001201892.2 no significant database hits YP_001201893.1 Codons 48 to the C-terminus are similar to codons 110 to 210 of Ralstonia metallidurans (strain CH34) hypothetical protein precursor. UniProt:Q3RNK6_RALME (368 aa) fasta scores: E()=7.7e-05, 51.020% id in 98 aa YP_001201894.1 Similar to Pseudomonas putida regulatory protein recx SWALL:RCXP_PSEPU (SWALL:Q8VMM5) (130 aa) fasta scores: E()=4.1e-17, id=52.68% id in 93 aa, and to Pseudomonas putida recx regulatory protein recx. UniProt:RECXP_PSEPU (130 aa) fasta scores: E()=7.4e-17, 52.688% id in 93 aa YP_001201897.1 no significant database hits YP_001201899.1 no significant database hits YP_001201900.1 no significant database hits YP_001201901.2 no significant database hits YP_001201902.1 Codons 88 to C-terminus are similar to codons 210 to 390 of Serratia entomophila PilV SWALL:AAR13116 (EMBL:AF135182) (477 aa) fasta scores: E()=0.0011, 25.946% id in 185 aa YP_001201903.2 no significant database hits YP_001201904.1 This CDS overlaps 11 nt at the C-terminus with pQBR0167 YP_001201905.1 This CDS overlaps 11 nt at the N-terminus with pQBR0166 YP_001201906.1 no significant database hits YP_001201908.1 no significant database hits YP_001201909.1 no significant database hits YP_001201910.1 no significant database hits YP_001201911.1 no significant database hits YP_001201912.1 no significant database hits YP_001201913.1 no significant database hits YP_001201917.1 no significant database hits YP_001201919.1 no significant database hits YP_001201920.1 no significant database hits YP_001201921.1 no significant database hits YP_001201923.1 no significant database hits YP_001201924.1 no significant database hits YP_001201926.1 no significant database hits YP_001201927.1 no significant database hits YP_001201930.1 no significant database hits YP_001201931.1 no significant database hits YP_001201932.1 no significant database hits YP_001201933.1 no significant database hits YP_001201934.1 no significant database hits YP_001201937.1 no significant database hits YP_001201938.1 C-terminus is similar to the C-terminus of Pseudomonas syringae conserved hypothetical protein pspto0859 SWALL:Q889A2 (EMBL:AE016858) (889 aa) fasta scores: E(): 8.1e-08, 23.1% id in 541 aa YP_001201940.1 no significant database hits YP_001201942.1 no significant database hits YP_001201943.1 no significant database hits YP_001201944.1 no significant database hits YP_001201945.1 no significant database hits YP_001201946.1 no significant database hits YP_001201953.1 no significant database hits YP_001201954.1 no significant database hits YP_001201959.1 no significant database hits YP_001201960.1 similar to INSD:BX572602 YP_001201961.1 no significant database hits. CDS start site is difficult to determine since there is a run of (GTG)10 at the N-terminus of the predicted gene YP_001201962.1 no significant database hits YP_001201966.1 no significant database hits YP_001201967.1 no significant database hits YP_001201972.1 no significant database hits YP_001201978.1 no significant database hits YP_001201980.1 no significant database hits YP_001201983.1 no significant database hits YP_001201987.1 no significant database hits YP_001201989.1 no significant database hits YP_001201990.1 no significant database hits YP_001201991.1 no significant database hits YP_001201992.1 no significant database hits YP_001201993.1 no significant database hits YP_001201994.1 no significant database hits YP_001201995.1 no significant database hits YP_001201998.1 no significant database hits YP_001201999.1 no significant database hits YP_001202000.1 no significant database hits YP_001202001.1 no significant database hits YP_001202003.1 no significant database hits YP_001202005.1 no significant database hits YP_001202006.1 no significant database hits YP_001202007.2 no significant database hits YP_001202008.1 no significant database hits YP_001202010.1 no significant database hits YP_001202012.1 no significant database hits YP_001202013.1 no significant database hits YP_001202014.1 no significant database hits YP_001202015.1 no significant database hits YP_001202016.1 no significant database hits YP_001202017.1 no significant database hits YP_001202018.1 no significant database hits YP_001202019.1 no significant database hits YP_001202020.1 no significant database hits YP_001202022.1 no significant database hits YP_001202023.1 no significant database hits YP_001202025.1 no significant database hits YP_001202026.1 no significant database hits YP_001202027.1 no significant database hits YP_001202029.1 no significant database hits YP_001202030.1 no significant database hits YP_001202032.1 no significant database hits YP_001202034.1 no significant database hits YP_001202035.1 no significant database hits YP_001202037.1 no significant database hits YP_001202039.1 no significant database hits YP_001202043.1 no significant database hits YP_001202044.2 no significant database hits YP_001202045.1 no significant database hits YP_001202046.1 no significant database hits YP_001202047.1 no significant database hits YP_001202048.1 no significant database hits YP_001202052.1 no significant database hits YP_001202053.1 no significant database hits YP_001202055.1 no significant database hits YP_001202056.1 no significant database hits YP_001202059.1 no significant database hits YP_001202061.2 no significant database hits YP_001202064.1 3'-5' exoribonuclease specific for small oligoribonuclotides YP_001202069.1 no significant database hits YP_001202071.1 Similar to Pseudomonas fluorescens hypothetical protein (fragment) SWALL:CAE84143 (EMBL:AJ617292) (205 aa) fasta scores: E(): 4.5e-83, 100% id in 205 aa. This CDS is extended at the C terminus 27 a.a. relative to the fragment YP_001202072.1 no significant database hits YP_001202074.1 no significant database hits YP_001202075.1 no significant database hits YP_001202076.1 no significant database hits YP_001202077.1 no significant database hits YP_001202078.1 Similar, but truncated at the N-terminus, to Shewanella sp. W3-18-1 hypothetical protein. UniProt:Q2X586 (EMBL:AALN01000015) (180 aa) fasta scores: E()=1.3e-08, 36.364% id in 132 aa YP_001202079.1 no significant database hits YP_001202080.1 no significant database hits YP_001202081.1 no significant database hits YP_001202082.1 no significant database hits YP_001202083.1 C-terminus is similar to Rhizobium meliloti hypothetical protein SWALL:Q91UT9 (EMBL:AJ304453) (183 aa) fasta scores: E(): 0.0016, 36.56% id in 134 aa YP_001202084.2 no significant database hits YP_001202085.1 no significant database hits YP_001202086.1 no significant database hits YP_001202087.1 no significant database hits YP_001202088.1 no significant database hits YP_001202089.1 no significant database hits YP_001202091.1 no significant database hits YP_001202092.1 no significant database hits YP_001202094.1 no significant database hits YP_001202095.1 no significant database hits YP_001202097.1 no significant database hits YP_001202098.1 no significant database hits YP_001202099.1 no significant database hits YP_001202100.1 no significant database hits YP_001202101.1 no significant database hits YP_001202102.1 no significant database hits YP_001202103.1 no significant database hits YP_001202104.1 no significant database hits YP_001202105.2 no significant database hits YP_001202106.1 no significant database hits YP_001202108.1 Similar to the C-terminus of Pseudomonas resinovorans hypothetical protein SWALL:Q8GHV5 (EMBL:AB088420) (309 aa) fasta scores: E(): 1.3e-10, 31.09% id in 164 aa. YP_001202109.1 no significant database hits YP_001202110.1 N-terminus is similar to entire Lactobacillus plantarum cold shock protein 1 Csp or CspP or lp_1160 SWALL:CSP1_LACPL (SWALL:P71478) (66 aa) fasta scores: E(): 0.0013, 45.16% id in 62 aa, and to entire protein is similar to Pseudomonas putida cold shock DNA-binding domain protein pp0636 SWALL:Q88Q61 (EMBL:AE016776) (246 aa) fasta scores: E(): 1e-30, 39.18% id in 245 aa YP_001202111.1 no significant database hits YP_001202112.1 no significant database hits YP_001202113.1 N-terminus is similar to the N-terminus of Anopheles gambiae str. PEST ensangp00000023027 SWALL:Q7PEK0 (EMBL:AAAB01007663) (128 aa) fasta scores: E(): 8.5e-07, 50% id in 76 aa YP_001202114.1 no significant database hits YP_001202115.1 no significant database hits YP_001202116.1 no significant database hits YP_001202117.1 C-terminus from codon 120 similar to the C-terminus from codon 120 of uncultured crenarchaeote 4B7 swi/snf family helicase SWALL:Q977S3 (EMBL:U40238) (570 aa) fasta scores: E(): 9.4e-23, 29.12% id in 436 aa YP_001202118.1 no significant database hits YP_001202119.1 no significant database hits YP_001202120.1 no significant database hits YP_001202122.1 no significant database hits YP_001202123.1 N-terminus is similar to the N-terminus of Pseudomonas aeruginosa DNA binding-protein AlgZ or pa3385 SWALL:Q9RPY7 (EMBL:AF139988) (108 aa) fasta scores: E(): 0.0099, 39.28% id in 84 aa YP_001202126.1 no significant database hits YP_001202127.1 no significant database hits YP_001202128.1 no significant database hits YP_001202129.1 The N-terminal 288 amino acids are similar to Escherichia coli RepA protein SWALL:Q08896 (EMBL:X73674) (288 aa) fasta scores: E(): 1.6e-42, 44.55% id in 294 aa YP_001202131.1 no significant database hits YP_001202134.1 no significant database hits YP_001202135.2 no significant database hits YP_001202136.1 no significant database hits YP_001202137.1 no significant database hits; Codons 80 to 242 are similar to codons 140 to 310 of Polaromonas sp. JS666 similar to periplasmic protein. UniProt:Q4B119_9BURK (437 aa) fasta scores: E()=3.9e-06, 32.955% id in 176 aa YP_001202140.1 no significant database hits YP_001202142.1 no significant database hits YP_001202143.1 no significant database hits YP_001202144.1 no significant database hits YP_001202145.1 no significant database hits YP_001202151.1 Similar, but extended at the C-terminus, to Nitrosomonas europaea hypothetical protein ne2572 SWALL:Q82RZ3 (EMBL:BX321865) (193 aa) fasta scores: E(): 3.4e-12, 36.5% id in 189 aa YP_001202152.1 no significant database hits YP_001202154.1 no significant database hits YP_001202156.1 no significant database hits YP_001202157.1 no significant database hits YP_001202160.1 no significant database hits YP_001202161.1 no significant database hits YP_001202163.1 no significant database hits YP_001202164.1 N-terminal 66 amino acids similar to the C-terminus of Pseudomonas aeruginosa hypothetical protein Pa4291 SWALL:Q9HWA9 (EMBL:AE004845) (228 aa) fasta scores: E(): 0.0011, 47.61% id in 63 aa YP_001202165.1 From codons 130-370 similar to codons 470 to the C-terminus of Rhizobium loti hypothetical protein Mlr1804 SWALL:Q98JS7 (EMBL:AP002998) (716 aa) fasta scores: E(): 0.0083, 27.68% id in 242 aa YP_001202166.1 no significant database hits YP_001202168.1 no significant database hits YP_001202169.1 no significant database hits YP_001202170.1 no significant database hits YP_001202171.1 no significant database hits YP_001202175.1 cleaves the carbon-mercury bond of organomercuric compounds YP_001202181.1 no significant database hits YP_001202182.1 no significant database hits YP_001202183.1 Required for efficient pilin antigenic variation YP_001202184.1 no significant database hits YP_001202185.1 no significant database hits YP_001202186.1 no significant database hits YP_001202187.1 no significant database hits YP_001202189.1 no significant database hits YP_001202191.1 no significant database hits YP_001202192.2 no significant database hits YP_001202193.1 no significant database hits YP_001202194.1 conserved hypothetical protein; Similar to C-terminus of Bacillus halodurans bh2961 protein. UniProt:Q9K8P2_BACHD (258 aa) fasta scores: E()=4, 29.126% id in 103 aa YP_001202195.1 no significant database hits YP_001202196.1 no significant database hits YP_001202197.1 no significant database hits YP_001202198.2 no significant database hits YP_001202199.2 no significant database hits YP_001202201.1 no significant database hits YP_001202202.1 no significant database hits YP_001202203.1 no significant database hits YP_001202205.1 no significant database hits YP_001202206.1 Similar to codons 70 to the C-terminus of Escherichia coli exodeoxyribonuclease I SbcB or XonA or CpeA or b2011 SWALL:EX1_ECOLI (SWALL:P04995) (475 aa) fasta scores: E()=1.5e-05, id=21.79% id in 413 aa, and to Xylella fastidiosa exodeoxyribonuclease I Xf2022 SWALL:Q9PBW3 (EMBL:AE004021) (494 aa) fasta scores: E()=8.3e-13, id=24.39% id in 451 aa, and to Escherichia coli SbcB synonyms=cpea, XonA UniProt:EX1_ECOLI (475 aa) fasta scores: E()=4.5e-05, 21.792% id in 413 aa, and to Methylococcus capsulatus SbcB orderedlocusnames=mca2382 UniProt:Q605A2_METCA (478 aa) fasta scores: E()=3.1e-13, 25.000% id in 488 aa YP_001202207.1 no significant database hits YP_001202208.2 no significant database hits YP_001202210.1 Similar, but truncated 100 residues at the N-terminus, to Escherichia coli RNA polymerase sigma factor RpoD or Alt or b3067 SWALL:RPOD_ECOLI (SWALL:P00579) (613 aa) fasta scores: E(): 2e-13, 25.48% id in 518 aa, and to Bordetella pertussis RNA polymerase sigma 80 subunit RpoD SWALL:P77833 (EMBL:U73858) (733 aa) fasta scores: E(): 9.4e-16, 25.09% id in 514 aa YP_001202211.1 no significant database hits YP_001202212.1 no significant database hits YP_001202214.1 no significant database hits YP_001202216.1 C-terminus is similar to Pseudomonas fluorescens WspE UniProt:Q842G9_PSEFL (755 aa) fasta scores: E()=7.9e-30, 28.017% id in 794 aa, and to Alkalilimnicola ehrlichei MLHE-1 UniProt:Q34VJ7_9GAMM (1795 aa) fasta scores: E()=2.5e-52, 27.083% id in 1928 aa. Possible alternative start site at codon 26 YP_001202221.1 no significant database hits YP_001202223.1 no significant database hits YP_002869698.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. YP_002869699.1 binds the polymerase to DNA and acts as a sliding clamp YP_002869700.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA YP_002869701.1 negatively supercoils closed circular double-stranded DNA YP_002869706.1 Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate YP_002869707.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_002869708.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_002869710.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA YP_002869712.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain YP_002869714.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth YP_002869715.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_002869717.1 similarity does not apply to the N-terminal region YP_002869720.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis YP_002869721.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate YP_002869728.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-galactonate 6-phosphate; functions in galactonate metabolism YP_002869732.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis YP_002869733.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_002869757.1 involved in the insertion of copper into subunit I of cytochrome C oxidase YP_002869763.1 converts protoheme IX and farnesyl diphosphate to heme O YP_002869767.1 part of the metNIQ transport system for methionine YP_002869768.1 Catalase HPII; monofunctional catalase that decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide YP_002869774.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine YP_002869776.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair YP_002869777.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential YP_002869789.1 carrier protein part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system YP_002869796.1 contains a possible sortase-binding site just before its C-teminal transmembrane region LDQTN, which could mean it is a putside membrane-bound protein YP_002869815.1 Similar to Bacillus licheniformis BacC in the D-phenylalanine activase domain YP_002869839.1 outer membrane protein essential for the synthesis of poly-beta-1,6-N-acetyl-D-glucosamine (PGA); adhesin required for biofilm formation; PgaA (HmsH) seems to translocate and/or dock PGA to the cell surface; member of the hmsHFRS (ycdSRQP or pgaABCD in Escherichia coli) operon in Yersinia YP_002869840.1 in Yersinia this protein is involved in biofilm formation and hemin adsorption; related protein PgaB in Escherichia coli is an outer membrane N-deacetylase involved in poly-beta-1,6-N-acetyl-D-glucosamine (PGA) export YP_002869841.1 predicted polysaccharide polymerase involved in biofilm formation; required for the synthesis of the beta-1,6-N-acetylglucosamine polysaccharide; PgaC; in Yersinia the HmsR protein is an inner membrane protein YP_002869844.1 N-terminal region similar to the Proteus database entry and C-terminal to the Escherichia coli one. Whole length of PLFU0148 similar to part of the Photorhabdus database entry YP_002869863.1 Bacteria have multiple sigma factors which are active under specific conditions; the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription YP_002869865.1 similarity to the database matches in PFLU0170 reduced to the N-terminal region YP_002869869.1 no full length similarity found in the database matches. Similar in its N-terminal region to the Wolbachia pipientis entry and in its C-terminal region to the Staphylococcus aureus entry YP_002869875.1 catalyzes the formation of succinate from succinate semialdehyde; NADP dependent YP_002869876.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate YP_002869892.1 (aryl-sulfate sulphohydrolase) YP_002869925.1 also similar to PFLU0242 (414 aa), E(): 2e-72; 50.646% identity in 387 aa overlap YP_002869931.1 catalyzes the formation of pyruvate from D-cysteine YP_002869936.1 catalyzes the conversion of taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde concurrently with the conversion of alpha-ketoglutarate to succinate and carbon dioxide; non-heme iron oxidase; allows the use of taurine as an alternative sulfur source; forms homodimers YP_002869938.1 Part of the ABC transporter complex tauABC involved in taurine import YP_002869940.1 involved in the first step of glutathione biosynthesis YP_002869943.1 part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation YP_002869950.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers YP_002869951.1 [ATP]; PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP YP_002869966.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose YP_002869976.1 catalyzes the formation of carbamoylputrescine from agmatine in the arginine decarboxylase pathway of putrescine biosynthesis YP_002869983.1 binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP) YP_002869984.1 catalyzes the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans YP_002870007.1 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis YP_002870008.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide YP_002870010.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide YP_002870011.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase YP_002870017.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate YP_002870020.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA YP_002870026.1 catalyzes the interconversion of chorismate to prephenate YP_002870029.1 Required for the synthesis of the thiazole moiety YP_002870035.1 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate YP_002870038.1 catalyzes the deimination of N-formimino-L-glutamate to ammonia and N-formyl-L-glutamate YP_002870041.1 catalyzes the formation of 4-imidazolone-5-propanoate from urocanate during histidine metabolism YP_002870046.1 also similar to the CDS just downstream, PFLU0367, hutH (512 aa); E(): 8.1e-55; 37.251% identity in 502 aa overlap YP_002870047.1 catalyzes the degradation of histidine to urocanate and ammmonia YP_002870049.1 catalyzing the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway YP_002870052.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine YP_002870053.1 involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan YP_002870054.1 necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space YP_002870061.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_002870063.1 Required for correct localization of precursor proteins bearing signal peptides with the twin arginine conserved motif YP_002870064.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes YP_002870065.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis YP_002870066.1 PR-AMP cyclohydrolase; functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers YP_002870069.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone YP_002870078.1 heat shock protein involved in degradation of misfolded proteins YP_002870079.1 heat shock protein involved in degradation of misfolded proteins YP_002870081.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_002870082.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity YP_002870088.1 N-terminus similar to Pseudomonas syringae PilO and C-terminus similar to Pseudomonas syringae PilP YP_002870089.1 catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis YP_002870090.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis YP_002870092.1 catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate YP_002870093.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate YP_002870094.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III YP_002870098.1 FabB; beta-ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_002870099.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_002870101.1 FabB; beta-ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_002870111.1 carries the fatty acid chain in fatty acid biosynthesis YP_002870121.1 small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS YP_002870122.1 the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli YP_002870127.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichai coli this protein also self-regulates transcription via a DNA-binding domain at the N-terminus; forms dimers and is a peripherally membrane-associated protein YP_002870133.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress YP_002870136.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC YP_002870137.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme YP_002870157.1 catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose YP_002870164.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A YP_002870166.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine YP_002870173.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_002870175.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_002870179.1 catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine YP_002870182.1 With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine YP_002870183.1 with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine YP_002870185.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity YP_002870186.1 3'-5' exoribonuclease specific for small oligoribonuclotides YP_002870189.1 similarity to the Pseudomonas syringae database match is limited to the C-terminal region of the latter YP_002870192.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex YP_002870193.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_002870194.1 Stimulates the elongation of poly(A) tails YP_002870198.1 May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine YP_002870199.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_002870205.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_002870206.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_002870208.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_002870209.1 unwinds double stranded DNA YP_002870217.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers YP_002870218.1 catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate YP_002870233.1 involved in the assembly of the urease metallocenter; possible nickel donor YP_002870248.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits YP_002870249.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); in Brucella suis the urease encoded by this operon (one of two urease-encoding operons found in its genome) is involved with urease activity, optimum growth, resistance to low-pH killing in-vitro and persistence in-vivo, while the other operon does not seem to be active YP_002870252.1 UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter YP_002870270.1 CobK/CbiJ; there are 2 pathways for cobalamin (vitamin B12) production, one aerobic (ex. P. denitrificans), the other anaerobic (ex. S. typhimurium); the CobK/CbiJ perform similar reactions in both; the anaerobic pathway includes the use of a chelated cobalt ion in order for ring contraction to occur; CobK thus converts precorrin 6 into dihydro-precorrin 6 while CbiJ converts cobalt-precorrin 6 into cobalt-deihydro-precorrin 6 YP_002870271.1 [decarboxylating] YP_002870273.1 catalyzes the interconversion of precorrin-8X and hydrogenobyrinate YP_002870274.1 catalyzes the formation of precorrin-3 from precorrin-2 YP_002870279.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_002870280.1 involved in de novo purine biosynthesis YP_002870281.1 Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription YP_002870284.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype YP_002870285.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_002870286.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_002870287.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis YP_002870292.1 involved in start site selection during the initiation of translation YP_002870293.1 catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis YP_002870298.1 penicillin-insensitive transglycosylase/transpeptidase YP_002870321.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_002870322.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_002870334.1 catalyzes the formation of inosine from adenosine YP_002870336.1 catalyzes the transformation of hydroxyatrazine to N-isopropylammelide and ethylamine in the atrazine degradation pathway. YP_002870342.1 catalyzes the formation of pyruvate and beta-alanine from L-alanine and 3-oxopropanoate YP_002870344.1 similarity is reduced to the C-terminal region of the to the E.coli entry. Possible duplication with the downstream CDS, PFLU0678 YP_002870345.1 similarity is reduced to the C-terminal region of the E.coli entry. Possible duplication with the upstream CDS, PFLU0677 YP_002870346.1 similarity reduced to the N-terminal region of the E.coli sequence YP_002870373.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_002870378.1 The N-terminal region of this CDS overlaps in 21 residues with the CDS upstream YP_002870379.1 N-terminal identical to the previously sequenced RscQA and C-terminal region identical to RscQB both from Pseudomonas fluorescens YP_002870380.1 part of a set of proteins involved in the infection of eukaryotic cells; in plant pathogens involved in the hypersensitivity response YP_002870394.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_002870395.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_002870396.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response YP_002870397.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_002870398.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis YP_002870399.1 Incorporates lipoproteins in the outer membrane after they are released by the LolA protein YP_002870401.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins YP_002870402.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_002870404.1 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase YP_002870405.1 converts L-glutamate to D-glutamate, a component of peptidoglycan YP_002870420.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic YP_002870424.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP YP_002870425.1 in Rhizobium meliloti this protein is involved in the synthesis of nodulation factors that are active on the roots of alfalfa; catalyzes formation of activated sulfate intermediate; converts ATP and sulfate to diphosphate and adenylylsulfate and then ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; the activated intermediate is transferred to the nodulation factors by NodH; may interact with NodP and NodQ; similar to the CysD and CysN proteins from EScherichia coli involved in cysteine biosynthesis YP_002870427.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate YP_002870430.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_002870432.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities YP_002870433.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme YP_002870434.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_002870436.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway YP_002870454.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis YP_002870460.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide YP_002870467.1 binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism YP_002870480.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein YP_002870483.1 Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides YP_002870498.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002870503.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_002870504.1 forms a direct contact with the tRNA during translation YP_002870512.1 catalyzes the formation of 2,5-dioxopentanoate from 5-dehydro-4-deoxy-D-glucarate YP_002870517.1 similarity reduced to parts of the sequence of the database matches YP_002870523.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_002870524.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_002870525.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain YP_002870526.1 functions in MreBCD complex in some organisms YP_002870527.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall YP_002870529.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell YP_002870537.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle YP_002870539.1 [Mn] YP_002870545.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen YP_002870557.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_002870558.1 short form of enzyme; requires HisZ for function; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms heteromultimer of HisG and HisZ YP_002870559.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_002870560.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_002870562.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate YP_002870563.1 Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively YP_002870567.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate YP_002870582.1 Catalyzes the reduction of hydroxypyruvate to form D-glycerate, using NADH as an electron donor YP_002870584.1 activates fatty acids by binding to coenzyme A YP_002870590.1 similarity to the E. coli database entry reduced to the C-terminal region of this entry YP_002870591.1 similarity to the E. coli database entry reduced to the C-terminal region of this entry YP_002870595.1 catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate YP_002870600.1 MraZ; UPF0040; crystal structure shows similarity to AbrB YP_002870604.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate YP_002870606.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_002870607.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation YP_002870609.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_002870610.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_002870611.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_002870614.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_002870615.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis YP_002870644.1 Depolymerizes alginate by cleaving the beta-1,4 glycosidic bond: may enhance the production of alginate by controlling the length of the polymer chain during export YP_002870655.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis YP_002870658.1 enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation YP_002870677.1 similarity reduced to parts of the sequence in the database matches YP_002870685.1 An oxygenase that acts to open the ring of homogentisate formingmaleylacetoacetate as part of the catabolism of L-tyrosine and L-phenylalanine YP_002870702.1 Bacteria have multiple sigma factors which are active under specific conditions; the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in Pseudomonas aeruginosa this protein may be involved in ferric dicitrate uptake YP_002870712.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_002870714.1 binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB YP_002870715.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides YP_002870718.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_002870720.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity YP_002870721.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_002870722.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA YP_002870723.1 involved in the de novo synthesis of pyridoxine (Vitamin B6) YP_002870740.1 Possible duplication as also similar to the downstream CDS PFLU1083 (792 aa), E(): 1.8e-154; 59.794% identity in 776 aa overlap YP_002870742.1 Possible duplication as also similar to the upstream CDS PFLU1081, (808 aa), E(): 1.3e-145; 59.923% identity in 776 aa overlap YP_002870767.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_002870790.1 similarity reduced to the N-terminal region of the sequence in the database matches YP_002870799.1 in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane YP_002870801.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP YP_002870805.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation YP_002870811.1 Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A) YP_002870812.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis YP_002870814.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming YP_002870819.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_002870822.1 This protein performs the mismatch recognition step during the DNA repair process YP_002870839.1 similarity reduced to the C-terminal part of this CDS YP_002870846.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_002870847.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities YP_002870859.1 catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit YP_002870863.1 involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans YP_002870865.1 catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation YP_002870870.1 catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation YP_002870879.1 regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins YP_002870881.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 YP_002870892.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate YP_002870893.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_002870907.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA YP_002870911.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica. YP_002870919.1 catalyzes the formation of succinyldiaminopimelate from N-succinyl-2-amino-6-ketopimelate YP_002870920.1 Catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein YP_002870921.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn YP_002870922.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_002870923.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_002870924.1 Catalyzes the phosphorylation of UMP to UDP YP_002870925.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_002870928.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate YP_002870932.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis YP_002870933.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP YP_002870934.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis YP_002870935.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM YP_002870936.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_002870937.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase YP_002870938.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein YP_002870940.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_002870941.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis YP_002870942.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_002870944.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers YP_002870948.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate YP_002870949.1 catalyzes the modification of U13 in tRNA(Glu) YP_002870950.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate YP_002870951.1 catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins YP_002870953.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor controls a regulon of genes required for protection against external stresses YP_002870963.1 catalyzes the ATP-dependent formation of a phosphodiester at the site of a single strand break in duplex DNA YP_002870974.1 helicase involved in DNA repair and perhaps also replication YP_002870978.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate YP_002870981.1 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH YP_002870992.1 Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine YP_002870993.1 Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine YP_002871001.1 transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA YP_002871014.1 catalyzes the thiolytic cleavage of beta-ketoadipyl-CoA to succinate and acetyl-CoA YP_002871018.1 Catalyzes the cycloisomerization of cis,cis-muconate YP_002871022.1 also similar to the downstream CDS, PFLU1374, (513 aa); E(): 2e-82; 49.894% identity in 471 aa overlap YP_002871023.1 also similar to the upstream CDS, PFLU1373, (497 aa); E(): 3.5e-82; 49.894% identity in 471 aa overlap YP_002871027.1 also similar to PFLU4009, (491 aa); E(): 4e-112; 69.165% identity in 467 aa overlap and to PFLU4118, (465 aa); E(): 5.4e-79; 52.766% identity in 470 aa overlap YP_002871032.1 similarity reduced to the C-terminal part of the sequence in the database YP_002871044.1 low G+C content (47.41%); No significant database matches YP_002871089.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine YP_002871093.1 the P. syringae entry presents similarities to the N-terminal region of PFLU1445 and the P. putaida entry to the C-terminal region YP_002871112.1 catalyzes the formation of oxaloacetate from L-aspartate YP_002871113.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor regulates genes involved in alginate biosynthesis YP_002871122.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_002871125.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_002871127.1 N-terminus presents similarities to the E. coli database entry and the C-terminus to the P. syringae entry YP_002871131.1 No significant database matches. Contains a TAT-secretion recognition signal close to the N-terminal region YP_002871152.1 catalyzes the formation of protocatechuate from 4-hydroxybenzoate YP_002871184.1 catalyzes the conversion of citrate to isocitrate YP_002871186.1 TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs YP_002871188.1 Required for the de novo synthesis of pyroxidine via the pdxA branch; catalyzes the formation of 3-hydroxy-4-phospho-hydroxy-alpha-ketobutyrate from erythronate-4-phosphate YP_002871195.1 includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids YP_002871196.1 FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids YP_002871198.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity YP_002871202.1 Represses a number of genes involved in the response to DNA damage YP_002871204.1 hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides YP_002871208.1 catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; involved in growth under gluconeogenic conditions and in glycolytic activity at high ATP concentrations in Corynebacterium; NAD and NADP dependent YP_002871210.1 catalyzes the conversion of NADPH to NADH YP_002871217.1 Also similar to PFLU4171, (224 aa); E(): 2.5e-44; 58.904% identity in 219 aa overlap YP_002871219.1 catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis YP_002871233.1 No significant database matches. Very low G+C content (39.53%) YP_002871234.1 No significant database matches. Very low G+C content (37.85%) YP_002871242.1 Similarity matches reduced to the N-terminal region of this CDS YP_002871254.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate YP_002871262.1 enzyme from Treponema denticola exhibits NADH-dependent trans-2-enoyl-CoA reductase activity YP_002871265.1 catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine YP_002871267.1 uncharacterized member of the major facilitator superfamily (MFS) YP_002871279.1 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate YP_002871280.1 Involved in ubiquinone biosynthesis YP_002871281.1 Catalyzes the hydrolytic cleavage of a carbon-halogen bond in N-ethylammeline YP_002871282.1 isomerizes methylthioribose-1-phosphate into methylthioribulose-1-phosphate; involved in methionine salvage pathway YP_002871283.1 negatively supercoils closed circular double-stranded DNA YP_002871284.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine YP_002871286.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_002871287.1 catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate and the formation of tyrosine from arogenate and catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_002871288.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP YP_002871289.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_002871291.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_002871314.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions YP_002871315.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions YP_002871316.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex YP_002871342.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive YP_002871345.1 catalyzes the formation of 2-dehydropantoate from (R)-pantoate YP_002871348.1 LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation YP_002871352.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_002871363.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_002871367.1 putative metalloprotease YP_002871368.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor YP_002871369.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress YP_002871379.1 dGTPase family type 3 subfamily, presumably hydrolyzes dGTP to deoxyguanosine and triphosphate YP_002871390.1 in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis YP_002871393.1 similarity with the E. coli entry reduced to the C-terminal region of the sequence in the database YP_002871395.1 ATP-binding protein; required for proper cytochrome c maturation YP_002871399.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane YP_002871425.1 required for the use of phosphonates and phosphite as phosphorus sources YP_002871435.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_002871439.1 catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate YP_002871450.1 member of the sodium:solute symporter family; cotranscribed with the acs gene which encodes acetyl coenzyme A synthase; mutations affect acetate uptake YP_002871451.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH YP_002871454.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol YP_002871455.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase YP_002871456.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide YP_002871457.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA YP_002871458.1 E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_002871459.1 catalyzes the interconversion of succinyl-CoA and succinate YP_002871460.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle YP_002871466.1 molecular chaperone YP_002871471.1 FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_002871472.1 catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP YP_002871476.1 [NAD(P)+]; catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_002871487.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase YP_002871494.1 also similar to the doswnstream CDS PFLU1860, (580 aa); E(): 1.7e-154; 70.639% identity in 579 aa overlap YP_002871495.1 also similar to the upstream CDS PFLU1859, (579 aa); E(): 7.3e-155; 70.639% identity in 579 aa overlap YP_002871500.1 functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA YP_002871512.1 Required for efficient pilin antigenic variation YP_002871519.1 also similar to PFLU5306, (114 aa); E(): 6.6e-30; 72.917% identity in 96 aa overlap YP_002871537.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_002871551.1 similarity reduced to the N-terminal region of the Escherichia coli database match YP_002871580.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_002871597.1 decatenates replicating daughter chromosomes YP_002871598.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA YP_002871615.1 also similar to PFLU1075, (254 aa); E(): 1.7e-68; 75.494% identity in 253 aa overlap YP_002871623.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_002871624.1 also similar to PFLU4796, (357 aa); E(): 3.3e-110; 93.056% identity in 288 aa overlap YP_002871631.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_002871633.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine YP_002871669.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_002871683.1 also similar to PFLU5423, (633 aa); E(): 5.4e-186; 74.718% identity in 621 aa overlap YP_002871686.1 Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C YP_002871750.1 catalyzes the conversion of shikimate to 3-dehydroshikimate YP_002871755.1 involved in the import of serine and threonine coupled with the import of sodium YP_002871763.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_002871766.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_002871773.1 decatenates replicating daughter chromosomes YP_002871793.1 P-type ATPase involved in magnesium influx YP_002871798.1 catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid YP_002871799.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive YP_002871805.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_002871811.1 catalyzes the reversible formation of diaminobutyrate and 2-oxoglutarate from glutamate and L-aspartic beta-semialdehyde YP_002871825.1 possible duplication with the downstream CDS PFLU2213, (327 aa); E(): 1.2e-39; 43.161% identity in 329 aa overlap YP_002871826.1 possible duplication with the upstream CDS PFLU2212, (340 aa); E(): 2.9e-40; 43.465% identity in 329 aa overlap YP_002871864.1 similarity reduced to the C-terminal region of the CDS sequence YP_002871892.1 catalyzes the formation of 2,5-dioxopentanoate from 5-dehydro-4-deoxy-D-glucarate YP_002871907.1 with XylFH is part of the high affinity xylose ABC transporter YP_002871909.1 catalyzes the interconversion of D-xylose to D-xylulose YP_002871925.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate YP_002871949.1 bifunctional enzyme DHBP synthase/GTP cyclohydrolase II-like protein; functions in riboflavin synthesis YP_002871972.1 catalyzes the formation of 3-methyl-2-oxobutanoate from 2,3,-dihydroxy-3-methylbutanoate YP_002871978.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose YP_002871979.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose YP_002872017.1 also similar to PFLU3240, (204 aa); E(): 1.4e-51; 71.287% identity in 202 aa overlap YP_002872043.1 catalyzes the formation of precorrin 6x from precorrin 5 YP_002872071.1 Converts D-sorbitol to L-sorbose YP_002872110.1 catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate YP_002872111.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers YP_002872125.1 aliphatic amidase; catalyzes the hydrolysis of short-chain aliphatic amides to their organic acids and can also transfer the acyl moiety of short-chain amides to hydroxylamine to form hydroxamates YP_002872132.1 catalyzes the specific recognition and activation of amino acids during peptide synthesis YP_002872133.1 catalyzes the specific recognition and activation of amino acids during peptide synthesis YP_002872146.1 catalyzes the formation of methanethiol and 2-ocobutanoate from L-methionine YP_002872196.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription YP_002872201.1 SohB; periplasmic protein; member of the peptidase S49 family YP_002872214.1 AcsA; in Sinorhizobium meliloti this enzyme is required for acetoacetate activation; similar to acetyl-CoA synthase YP_002872215.1 catalyzes the formation of acetoacetate from 3-hydroxybutyrate YP_002872231.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids YP_002872232.1 3'-5' exonuclease of DNA polymerase III YP_002872239.1 [cytochrome]; catalyzes the formation of acetate from pyruvate YP_002872246.1 one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity YP_002872254.1 with CobST catalyzes the formation of cobyrinic acid a,c-diamide from hydrogenobyrinic acid a,c-diamide in an ATP-dependent manner; involved in porphyrin and chlorophyll metabolism; vitamin B12 metabolism YP_002872258.1 catalyzes the phosphorylation of NAD to NADP YP_002872273.1 Doubtful CDS YP_002872274.1 similar to full-length Gnd, these proteins seems to have a truncated C-terminal 6PGD domainin; in Methylobacillus flagellatus this gene is essential for NAD+-dependent oxidation of 6-phosphogluconate YP_002872275.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_002872277.1 Doubtful CDS YP_002872308.1 Bacteria have multiple sigma factors which are active under specific conditions; the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription YP_002872344.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain YP_002872358.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_002872359.1 can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates YP_002872364.1 Catalyzes the rate-limiting step in dNTP synthesis YP_002872389.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell YP_002872393.1 FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds YP_002872489.1 catalyzes the ATP dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA YP_002872495.1 catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome YP_002872566.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense YP_002872592.1 CcoN; FixN YP_002872619.1 catalyzes the addition of 4-amino-4-deoxy-L-arabinose to lipid A YP_002872621.1 Bifunctional polymyxin resistance arnA protein; catalyzes the decarboxylation of UDP-glucuronic acid to UDP-4-keto-arabinose and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose to form UDP-L-4-formamido-arabinose; active in certain mutant strains YP_002872650.1 catalyzes the formation of L-proline from L-ornithine YP_002872659.1 catalyzes the formation of 3-(2,3-dihydroxyphenyl)propionate from 3-(3-hydroxyphenyl)propionate YP_002872665.1 thiamine-pyrophosphate requiring enzyme YP_002872684.1 FabF, beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP. YP_002872732.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate YP_002872765.1 paralogs to the E1 component of pyruvate dehydrogenase subunit E1 YP_002872773.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs YP_002872777.1 No significant database matches. Doubtful CDS YP_002872780.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia YP_002872854.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_002872856.1 activator of genes involved in phenylacetic acid catabolism YP_002872869.1 catalyzes the conversion of ferulic acid to feruloyl-CoA YP_002872871.1 catalyzes the conversion of feruloyl-CoA to vanillin and acetyl-CoA YP_002872876.1 catalyzes the formation of 5-alpha-androstane-3,17-dione from androsterone; Acts on other 3-alpha-hydroxysteroids and on 9-, 11- and 15-hydroxyprostaglandin. YP_002872886.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_002872933.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose YP_002872992.1 [NAD(P)H] YP_002873019.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia YP_002873053.1 catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate YP_002873064.1 involved in the transport of C4-dicarboxylates across the membrane YP_002873088.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_002873090.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_002873091.1 functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA YP_002873132.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine YP_002873149.1 catalyzes the formation of glutamate from glutamine YP_002873164.1 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis. It is not the major replicative DNA polymerase. YP_002873167.1 Represses a number of genes involved in the response to DNA damage YP_002873210.1 catalyzes the release of C-terminal glutamate residues from N-acylating moieties YP_002873322.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_002873324.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS YP_002873326.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate YP_002873340.1 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs YP_002873344.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs YP_002873345.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs YP_002873351.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002873352.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling YP_002873354.1 participates with LolB in the incorporation of lipoprotein into the outer membrane YP_002873356.1 leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys YP_002873357.1 Conjugates Arg from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate YP_002873358.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_002873360.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA YP_002873362.1 [NADP] YP_002873363.1 [NADP] YP_002873365.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_002873366.1 HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis YP_002873367.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_002873372.1 Catalyzes the transfer of electrons from NADH to quinone YP_002873373.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen YP_002873374.1 NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms YP_002873375.1 Catalyzes the transfer of electrons from NADH to quinone YP_002873376.1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase YP_002873377.1 Catalyzes the transfer of electrons from NADH to quinone YP_002873378.1 Catalyzes the transfer of electrons from NADH to quinone YP_002873379.1 Catalyzes the transfer of electrons from NADH to quinone YP_002873380.1 Catalyzes the transfer of electrons from NADH to quinone YP_002873381.1 Catalyzes the transfer of electrons from NADH to quinone YP_002873382.1 Catalyzes the transfer of electrons from NADH to ubiquinone YP_002873383.1 Catalyzes the transfer of electrons from NADH to quinone YP_002873384.1 Catalyzes the transfer of electrons from NADH to quinone YP_002873417.1 subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_002873418.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone YP_002873419.1 subunit E of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport YP_002873420.1 subunit F of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport YP_002873421.1 subunit G of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport YP_002873423.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_002873424.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002873426.1 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine YP_002873434.1 removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction YP_002873439.1 catalyzes the formation of acetoacetate and acetyl-CoA from 3-hydroxy-3-methylglutaryl-CoA YP_002873443.1 catalyzes the hydration of gamma-carboxygeranoyl-CoA to 3-hydroxy-gamma-carboxygeranoyl-CoA YP_002873463.1 catalyzes the formation of phosphonoacetaldehyde from 2-aminoethylphosphonate and pyruvate YP_002873464.1 catalyzes the degradation of phosphonoacetaldehyde to acetaldehyde and phosphate YP_002873472.1 paralogs to the E1 component of pyruvate dehydrogenase subunit E1 YP_002873478.1 also similar to PFLU1926 (pseudogene) and PFLU6032 YP_002873480.1 binds and unfolds substrates as part of the ClpXP protease YP_002873481.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_002873482.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_002873483.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate YP_002873484.1 specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7 YP_002873492.1 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide YP_002873494.1 catalyzes the hydrolytic cleavage of hydantoin with aromatic side chains at the 5'position YP_002873495.1 function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain YP_002873496.1 catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines YP_002873518.1 E3 component of the branched-chain alpha-keto acid dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_002873519.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_002873521.1 catalyzes the formation of L-proline from L-ornithine YP_002873527.1 Bacteria have multiple sigma factors which are active under specific conditions; the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in Pseudomonas aeruginosa this extracytoplasmic function sigma factor may be involved in the transcription of the ferric pyoverdine receptor gene, fpvA. YP_002873538.1 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide YP_002873555.1 catalyzes the addition of 4-amino-4-deoxy-L-arabinose to lipid A YP_002873575.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_002873577.1 Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation YP_002873578.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate YP_002873590.1 [NADP+] YP_002873591.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine YP_002873638.1 part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic subunit SsuB the ATP-binding subunit and SsuC the permease YP_002873639.1 Part of the FecBCDE citrate-dependent iron (III) transport system YP_002873641.1 part of the FecBCDE citrate-dependent iron (III) transport system YP_002873642.1 part of the ABC transporter involved in the uptake of citrate-dependent Fe(3+) YP_002873660.1 catalyzes the formation of 3-(2,3-dihydroxyphenyl)propionate from 3-(3-hydroxyphenyl)propionate YP_002873674.1 Doubtful CDS YP_002873692.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_002873693.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_002873694.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_002873695.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_002873697.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits YP_002873698.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) YP_002873705.1 cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source YP_002873731.1 catalyzes the conversion of O-succinylhomoserine into homocysteine YP_002873732.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_002873735.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits YP_002873736.1 catalyzes the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)-anthranilate in tryptophan biosynthesis YP_002873737.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_002873739.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde YP_002873740.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde YP_002873741.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis YP_002873743.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D YP_002873744.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_002873754.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_002873755.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_002873756.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate YP_002873810.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine YP_002873822.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress YP_002873843.1 flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration YP_002873852.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle YP_002873856.1 catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules YP_002873869.1 activates fatty acids by binding to coenzyme A; may be involved in acyclic terpene utilization YP_002873874.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_002873877.1 involved in methylation of ribosomal protein L3 YP_002873881.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer YP_002873897.1 catalyzes the formation of S-ureidoglycolate and urea from allantoate YP_002873898.1 catalyzes the formation of glyoxylate from (S)-ureidoglycolate YP_002873903.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA YP_002873904.1 blocks the formation of polar Z-ring septums YP_002873906.1 works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell YP_002873908.1 catalyzes the removal of amino acids from the N termini of peptides YP_002873913.1 catalyzes the reversible formation of diaminobutyrate and 2-oxoglutarate from glutamate and L-aspartic beta-semialdehyde YP_002873919.1 Involved in disulfide bond formation YP_002873922.1 catalyzes the specific recognition and activation of amino acids during peptide synthesis; involved in the biosynthesis of the peptide chain of pyoverdines YP_002873924.1 RNA polymerase sigma factor involved in the synthesis of the siderophores pyoverdine in Pseudomonas and malleobactin in Burkholderia; also involved in the synthesis of exotoxin and PrpL protease YP_002873940.1 cytosolic protein with phosphatidylglycerol kinase activity; undetermined physiological role YP_002873945.1 Homologous to MotB. These organism have both MotB and MotD. With MotC (a MotA homolog) forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine. Either MotAB or MotCD is sufficient for swimming, but both are necessary for swarming motility YP_002873946.1 homologous to MotA; this protein with a related protein (a MotB homolog) forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; either MotAB or MotCD is sufficient for swimming, but both are necessary for swarming motility; these organisms have both MotA and MotC YP_002873947.1 regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins YP_002873951.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes YP_002873953.1 positive regulator of class III flagellar genes YP_002873954.1 membrane protein involved in the flagellar export apparatus YP_002873956.1 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export YP_002873957.1 FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus YP_002873958.1 with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus YP_002873959.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus YP_002873961.1 One of three proteins involved in switching the direction of the flagellar rotation YP_002873962.1 with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation YP_002873963.1 interacts with the cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring YP_002873968.1 rod/hook and filament chaperone YP_002873969.1 involved in type III protein export during flagellum assembly YP_002873970.1 binds to and inhibits the function of flagella specific ATPase FliI YP_002873971.1 One of three proteins involved in switching the direction of the flagellar rotation YP_002873972.1 the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod YP_002873973.1 forms a junction between the M-ring and FlgB during flagella biosynthesis YP_002873978.1 flagellin specific chaperone YP_002873983.1 With FlgK acts as a hook filament junction protein to join the flagellar filament to the hook YP_002873984.1 with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook YP_002873985.1 Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space YP_002873986.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum YP_002873987.1 part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod YP_002873988.1 makes up the distal portion of the flagellar basal body rod YP_002873989.1 FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod YP_002873991.1 phenylalanine 4-hydroxylase; phenylalanine 4-hydroxylase; catalyzes the formation of 4a-hydroxytetrahydrobiopterin and tyrosine from phenylalanine and tetrahydrobiopterin YP_002873992.1 4-alpha-hydroxytetrahydrobiopterin dehydratase activity; catalyzes the formation of (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7, 8-dihydro-6H-pterin from (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7, 8-tetrahydro-4a-hydroxypterin; functions in recycling tetrahydrobiopterin (BH4) in phenylalanine hydroxylase reaction YP_002873993.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate YP_002874013.1 catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole YP_002874015.1 catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole YP_002874016.1 catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP YP_002874017.1 catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation YP_002874018.1 cobalamin biosynthesis protein; decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin; structurally similar to histidinol phosphate aminotransferase YP_002874019.1 CobD; CbiD in Salmonella; converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group YP_002874021.1 responsible for the amidation of carboxylic groups at position A and C of cobyrinic acid or hydrogenobrynic acid YP_002874022.1 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide YP_002874026.1 controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP YP_002874029.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_002874030.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate YP_002874034.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era YP_002874036.1 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S] YP_002874037.1 catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide YP_002874068.1 catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs YP_002874074.1 catalyzes the phosphorylation/dephosphorylation of the enzyme isocitrate dehydrogenase on a specific serine which regulates activity; unphosphorylated IDH is fully active when cells are grown on glucose while the enzyme becomes phosphorylated and inactive in the presence of acetate or ethanol YP_002874080.1 CcoN; FixN YP_002874081.1 CcoO; FixO YP_002874084.1 CcoN; FixN YP_002874085.1 CcoO; FixO YP_002874093.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_002874096.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis YP_002874099.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_002874102.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA YP_002874112.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB YP_002874113.1 interacts directly with the cell division protein ftsZ; probable receptor for the septal ring structure, may anchor it to the inner-membrane YP_002874119.1 Catalyzes the deamination of guanine YP_002874125.1 catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA YP_002874126.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors YP_002874133.1 catalyzes 2 sequential methylations, the formation of precorrin-1 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and uroporphyrin III, and the formation of precorrin-2 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and precorrin-1 YP_002874135.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in Pseudomonas fluorescens and P. aeruginosa regulates outer membrane protein OprF expression YP_002874139.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity YP_002874141.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_002874145.1 similarity reduced to the C-terminal end of the CDS YP_002874149.1 functions in propionate metabolism; involved in isomerization of (2S,3S)-methylcitrate to (2R,3S)-methylisocitrate; also encodes minor aconitase or dehydratase activity; aconitase C YP_002874151.1 Catalyzes the conversion of citrate to isocitrate YP_002874152.1 catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity YP_002874153.1 catalyzes the formation of pyruvate and succinate from 2-methylisocitrate YP_002874162.1 catalyzes the formation of serine from phosphoserine; also has phosphoserine:homoserine phosphotransferase activity YP_002874163.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite YP_002874167.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_002874173.1 also similar to PFLU5680, (316 aa); E(): 2.4e-56; 50.323% identity in 310 aa overlap YP_002874178.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_002874183.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_002874203.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose YP_002874204.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose YP_002874220.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA YP_002874221.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) YP_002874223.1 catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate YP_002874224.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_002874225.1 carries the fatty acid chain in fatty acid biosynthesis YP_002874226.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_002874228.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY YP_002874229.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_002874231.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell YP_002874238.1 involved in the transport of C4-dicarboxylates across the membrane YP_002874247.1 Catalyzes the rate-limiting step in dNTP synthesis YP_002874249.1 the hook connects flagellar basal body to the flagellar filament YP_002874250.1 acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production YP_002874251.1 with FlgF and B makes up the proximal portion of the flagellar basal body rod YP_002874252.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella YP_002874255.1 required for the assembly of the flagellar basal body P-ring YP_002874264.1 affects carbohydrate metabolism; has regulatory role in many processes YP_002874265.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation. YP_002874266.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002874268.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_002874269.1 catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism YP_002874271.1 catalyzes the hydrolysis of 2-N-succinylarginine into 2-N-succinylornithine, ammonia and carbon dioxide in arginine degradation YP_002874272.1 a high throughput screen identified this enzyme as an aldehyde dehydrogenase with broad substrate specificity; converts succinylglutamate semialdehyde and NAD to succinylglutamate and NADH YP_002874275.1 DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate YP_002874283.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA YP_002874285.1 Catalyzes the rate-limiting step in dNTP synthesis YP_002874286.1 very low G+C content, 37.8% YP_002874287.1 doubtful CDS. Annotated as hit to insertion element ISPa4 YP_002874338.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_002874341.1 activates fatty acids by binding to coenzyme A; involved in the beta-oxidation of n-alkanoic and n-phenylalkanoic acids YP_002874342.1 Disruption of the fadD2 gene did not have any effect on the catabolism of acetic, butyric and longer fatty acids (aliphatic or aromatic); however, might be involved in the specific activation of other fatty acids and may be functional when FadD1 is inactivated. YP_002874348.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate YP_002874350.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_002874351.1 Represses the expression of the zwf, eda, glp and gap YP_002874363.1 specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport YP_002874387.1 Involved in cell division; probably involved in intracellular septation YP_002874397.1 catalyzes the degradation of arginine to citruline and ammonia YP_002874398.1 catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway YP_002874399.1 reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP YP_002874402.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor YP_002874403.1 [decarboxylating]; acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine YP_002874408.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate YP_002874414.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA YP_002874419.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_002874420.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_002874421.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity YP_002874423.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_002874433.1 putative nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription YP_002874434.1 catalyzes the formation of 2-dehydropantoate from (R)-pantoate YP_002874438.1 bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate YP_002874439.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; in some organisms, there are paralogous proteins that have been found to be nonessential but do function in secretion of a subset of exported proteins YP_002874444.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine YP_002874446.1 Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates YP_002874455.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_002874469.1 catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate YP_002874470.1 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate YP_002874483.1 MexW; inner membrane protein; member of RND (resistance, nodulation, and division) family; involved in resistance to fluoroquinolones, tetracycline, chloramphenicol, erythromycin, ethidium bromide, and acriflavine; functions along with MexV and OprM YP_002874485.1 MexW; inner membrane protein; member of RND (resistance, nodulation, and division) family; involved in resistance to fluoroquinolones, tetracycline, chloramphenicol, erythromycin, ethidium bromide, and acriflavine; functions along with MexV and OprM YP_002874493.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_002874494.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_002874495.1 F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein YP_002874500.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_002874502.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function YP_002874510.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_002874511.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine YP_002874513.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_002874514.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_002874515.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_002874516.1 Essential for efficient processing of 16S rRNA YP_002874517.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_002874522.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis YP_002874538.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_002874539.1 YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function YP_002874546.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_002874547.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate YP_002874551.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_002874555.1 catalyzes the transfer of an amino moiety YP_002874556.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_002874559.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_002874560.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis YP_002874564.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate YP_002874567.1 involved in the maturation of iron-sulfur cluster-containing proteins YP_002874568.1 J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins YP_002874571.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis YP_002874577.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF YP_002874578.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane YP_002874579.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex YP_002874580.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) YP_002874581.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step YP_002874593.1 regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins YP_002874594.1 catalyzes the conversion of glutamine residues to glutamate on methyl-accepting chemotaxis receptors YP_002874624.1 putative heme oxygenase YP_002874639.1 converts protoheme IX and farnesyl diphosphate to heme O YP_002874644.1 disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein YP_002874645.1 flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine YP_002874646.1 Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon YP_002874655.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_002874661.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer YP_002874662.1 catalyzes the formation of dihydromonapterin triphosphate from dihydroneopterin triphosphate YP_002874666.1 putative role in sulfur assimilation YP_002874671.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis YP_002874672.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_002874673.1 involved in the peptidyltransferase reaction during translation YP_002874700.1 catalyzes the formation of catechol from anthranilate YP_002874718.1 in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme YP_002874719.1 in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ YP_002874721.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_002874722.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit YP_002874723.1 catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; also known as acetolactate synthase large subunit YP_002874730.1 with HmuTU is involved in the transport of hemin YP_002874734.1 Regulatory factor involved in maltose metabolism YP_002874737.1 this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu YP_002874743.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate YP_002874744.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine YP_002874745.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_002874746.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA YP_002874752.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_002874753.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs YP_002874754.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock YP_002874755.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_002874756.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_002874757.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins YP_002874759.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate YP_002874760.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_002874766.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_002874767.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity YP_002874768.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_002874769.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_002874770.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_002874771.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_002874772.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor YP_002874778.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_002874790.1 identical to PFLU2400 and PFLU5851 YP_002874803.1 this CDS has an alternative start codon at codon 19 YP_002874825.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer YP_002874826.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence YP_002874829.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_002874836.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_002874839.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock YP_002874852.1 catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs YP_002874862.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis YP_002874863.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate YP_002874864.1 This CDS seems to have an alternative start codon at residue 23 YP_002874894.1 Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile YP_002874897.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine YP_002874898.1 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate YP_002874899.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway YP_002874902.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) YP_002874906.1 Transfers the fatty acyl group on membrane lipoproteins YP_002874908.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_002874910.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA YP_002874914.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_002874915.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein YP_002874922.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA YP_002874923.1 This CDS contains a possible alternative start codon in residue 40 YP_002874924.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria YP_002874925.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway YP_002874926.1 responsible for recognizing base lesions in the genome and initiating base excision DNA repair YP_002874942.1 catalyzes the formation of acetaldehyde from ethanolamine YP_002874946.1 catalyzes the hydrolysis of pyrophosphate to phosphate YP_002874955.1 catalyzes the bidirectional exonucleolytic cleavage of DNA YP_002874957.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_002874961.1 catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate YP_002874963.1 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP YP_002874964.1 Regulates rRNA biosynthesis by transcriptional antitermination YP_002874965.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_002874966.1 bifunctional enzyme DHBP synthase/GTP cyclohydrolase II-like protein; functions in riboflavin synthesis YP_002874967.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine YP_002874968.1 [includes: diaminohydroxyphosphoribosylaminopyrimidine deaminase; 5-amino-6-(5-phosphoribosylamino)uracil reductase] YP_002874983.1 This CDS has a possible alternative start codon at residue 34 YP_002874990.1 No significant database matches. Low GC content YP_002874991.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA YP_002874993.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate YP_002874996.1 is a component of the macrolide binding site in the peptidyl transferase center YP_002874997.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_002874998.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_002874999.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_002875000.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_002875001.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif YP_002875002.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_002875003.1 late assembly protein YP_002875004.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_002875005.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_002875006.1 binds 5S rRNA along with protein L5 and L25 YP_002875007.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_002875008.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_002875009.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif YP_002875010.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_002875011.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_002875012.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_002875013.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_002875014.1 one of the stabilizing components for the large ribosomal subunit YP_002875015.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_002875016.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_002875017.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_002875018.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_002875019.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_002875020.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_002875021.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_002875022.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_002875023.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex YP_002875024.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_002875025.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_002875026.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_002875027.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_002875028.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_002875029.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_002875030.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_002875031.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_002875032.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_002875033.1 binds directly to 23S ribosomal RNA YP_002875034.1 Modulates Rho-dependent transcription termination YP_002875035.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_002875037.1 type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP YP_002875038.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon YP_002875039.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) YP_002875041.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling YP_002875042.1 essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors YP_002875043.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate YP_002875051.1 complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons YP_002875053.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water YP_002875054.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate YP_002875055.1 TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity YP_002875056.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine YP_002875057.1 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate YP_002875058.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate YP_002875072.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate) YP_002875073.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_002875074.1 protein associated with Co2+ and Mg2+ efflux YP_002875075.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP YP_002875076.1 belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine YP_002875080.1 [includes: cca-adding enzyme (ec 2.7.7.25) (ec 2.7.7.21) (trna nucleotidyltransferase) (trna adenylyl-/cytidylyl-transferase) (trna cca-pyrophosphorylase) (trna-nt); 2'-nucleotidase (ec 3.1.3.-); 2',3'-cyclic phosphodiesterase (ec 3.1.4.-); phosphatase (ec 3.1.3.-)]; catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases YP_002875083.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX YP_002875084.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_002875086.1 synthesizes RNA primers at the replication forks YP_002875087.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria YP_002875093.1 Required for coenzyme pyrroloquinoline quinone (PQQ) biosynthesis; probably provides the glutamate and tyrosine residues that are cross-linked and modified to form the coenzyme YP_002875094.1 possibly involved in transport of pyrroloquinoline quinone transport YP_002875095.1 Required in the synthesis of PPQ, but its exact function is unknown YP_002875096.1 with PqqC converts a biosynthetic intermediate to pyrroloquinoline quinone YP_002875101.1 possible duplication of downstream CDSs PFLU5606, (593 aa); E(): 1.6e-127; 56.734% identity in 594 aa overlap and PFLU5609, (633 aa); E(): 7.9e-118; 52.508% identity in 598 aa overlap YP_002875102.1 possible duplication of downstream and upstream CDSs PFLU5609, (633 aa); E(): 7.8e-157; 65.557% identity in 601 aa overlap and PFLU5606, (593 aa); E(): 1.6e-127; 56.734% identity in 594 aa overlap YP_002875104.1 possible duplication with upstream CDSs, PFLU5607, (609 aa); E(): 1.3e-1565; 65.557% identity in 601 aa overlap and PFLU5606, (593 aa); E(): 1.2e-121; 52.508% identity in 598 aa overlap YP_002875106.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium YP_002875109.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine YP_002875114.1 catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages YP_002875117.1 catalyzes the formation of malate from glyoxylate and acetyl-CoA YP_002875121.1 Bacteria have multiple sigma factors which are active under specific conditions; the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in P. aeruginosa this sigma factor regulates the production of the ferrichrome outer membrane receptor FiuA. YP_002875134.1 part of a two-component regulatory system with CreB or PhoB; involved in catabolic regulation YP_002875135.1 response regulator in two-component regulatory system with CreC; CreB protein is phosphorylated by sensor protein phospho-CreC; involved in catabolic regulation YP_002875141.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine YP_002875146.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_002875168.1 converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA YP_002875173.1 also similar to PFLU4652, (312 aa); E(): 2.2e-57; 50.323% identity in 310 aa overlap YP_002875176.1 also similar to PFLU0249, (704 aa); E(): 5.5e-117; 51.267% identity in 671 aa overlap YP_002875177.1 HTH-type; bet1; Repressor involved in choline regulation of the bet genes YP_002875178.1 catalyzes the formation of betaine from betaine aldehyde YP_002875179.1 catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine YP_002875184.1 exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA YP_002875194.1 class II aldolase; catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis YP_002875197.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_002875199.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase YP_002875201.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_002875203.1 this ligase is similar to LigA but it lacks the C-terminal BRCT domain; catalyzes strand joining of nicked DNA in the presence of a divalent cation and NAD+ YP_002875212.1 catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine YP_002875219.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate YP_002875220.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_002875230.1 Catalyzes the transfer of 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A to the apo-acyl carrier protein of malonate dehydrogenase to form holo-acyl carrier protein YP_002875232.1 The beta subunit catalyzes the decarboxylation of the malonyl moiety on coenzyme A YP_002875233.1 acyl carrier protein of malonate decarboxylase YP_002875234.1 catalyzes the reversible formation of 2'-(5''-triphosphoribosyl)-3'dephospho-CoA from 3-dephospho-CoA YP_002875243.1 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione YP_002875246.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function YP_002875247.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity YP_002875248.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis YP_002875249.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis YP_002875254.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate YP_002875256.1 Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine YP_002875259.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine YP_002875260.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_002875262.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine YP_002875263.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate YP_002875264.1 with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate YP_002875266.1 glycosyltransferase; polymerizes glycan strands in the peptidoglycan YP_002875267.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters YP_002875280.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_002875282.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases YP_002875283.1 this CDS has a possible alternative start codon at residue 26 YP_002875286.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_002875305.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein YP_002875309.1 hydrolyzes diadenosine polyphosphate YP_002875312.1 threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway YP_002875313.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway YP_002875318.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate YP_002875342.1 part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic substrate-binding subunit, SsuB the ATP-binding subunit and SsuC the permease YP_002875344.1 catalyzes the release of sulfite from alkanesulfonates YP_002875349.1 catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis YP_002875350.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis YP_002875360.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor YP_002875361.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein YP_002875364.1 catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol YP_002875366.1 Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone YP_002875368.1 the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown YP_002875379.1 catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell YP_002875383.1 catalyzes the formation of 3,6-dideoxy-D-glycero-D-glycero-4-hexulose YP_002875386.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_002875398.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate YP_002875399.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_002875415.1 binds specifically to the major sigma factor sigma 70; active in stationary phase YP_002875419.1 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane YP_002875420.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis YP_002875422.1 catalyzes the formation of arginine from (N-L-arginino)succinate YP_002875426.1 catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP YP_002875427.1 Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation YP_002875429.1 defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly YP_002875432.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate YP_002875434.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_002875445.1 functions as a Na(+)/drug antiporter YP_002875448.1 Catalyzes the transfer of the phosphoribosyl moiety from 5-phospho--D-ribosyl-1-pyrophosphate (PRib-PP) to the 6-oxo-guanine and -xanthine YP_002875452.1 catabolic enzyme, converts L-alanine to D-alanine which is then oxidized to pyruvate by dadA YP_002875454.1 catalyzes the oxidative deamination of D-amino acids YP_002875467.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase YP_002875468.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine YP_002875469.1 catalyzes the formation of dUMP from dUTP YP_002875471.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate YP_002875472.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_002875475.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs YP_002875477.1 Essential for recycling GMP and indirectly, cGMP YP_002875478.1 Promotes RNA polymerase assembly; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits YP_002875484.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell YP_002875487.1 catalyzes branch migration in Holliday junction intermediates YP_002875512.1 possible duplication with the dowstream CDS PFLU6030, (1460 aa); E(): 0; 71.470% identity in 1381 aa overlap YP_002875514.1 possible duplication with the upstream CDS PFLU6028, (1477 aa); E(): 0; 71.398% identity in 1381 aa overlap YP_002875520.1 catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway YP_002875528.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_002875537.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway YP_002875540.1 catalyzes the formation of fumarate from aspartate YP_002875551.1 catalyzes the formation of oxaloacetate from pyruvate YP_002875552.1 biotin carboxylase; with subunit B, the carboxyltansferase/biotincarboxyl carrier subunit catalyzes the formation of oxaloacetate from pyruvate YP_002875556.1 unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair. YP_002875562.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal YP_002875570.1 similar protein in Methanocaldococcus converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate as the first step in methanopterin biosynthesis YP_002875576.1 Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides YP_002875578.1 catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol) YP_002875595.1 No significant database matches. Doubtful CDS YP_002875596.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source YP_002875598.1 GlmU protein YP_002875599.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane YP_002875600.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_002875601.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_002875602.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_002875603.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex YP_002875604.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. YP_002875605.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 YP_002875606.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_002875607.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation YP_002875610.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA YP_002875611.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_002875615.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_002875616.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria YP_002875617.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates YP_002875618.1 in Escherichia coli transcription of this gene is enhanced by polyamines