-- dump date 20111121_014111 -- class Genbank::misc_feature -- table misc_feature_note -- id note 216595000001 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 216595000002 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 216595000003 P loop; other site 216595000004 Nucleotide binding site [chemical binding]; other site 216595000005 DTAP/Switch II; other site 216595000006 Switch I; other site 216595000007 ParB-like nuclease domain; Region: ParBc; cl02129 216595000008 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 216595000009 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 216595000010 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 216595000011 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 216595000012 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 216595000013 metal ion-dependent adhesion site (MIDAS); other site 216595000014 Protein of unknown function (DUF3150); Region: DUF3150; pfam11348 216595000015 SprT homologues; Region: SprT; cl01182 216595000016 AAA-like domain; Region: AAA_10; pfam12846 216595000017 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595000018 Walker A motif; other site 216595000019 ATP binding site [chemical binding]; other site 216595000020 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 216595000021 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 216595000022 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 216595000023 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595000024 Walker A motif; other site 216595000025 ATP binding site [chemical binding]; other site 216595000026 Walker B motif; other site 216595000027 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 216595000028 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 216595000029 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 216595000030 general secretion pathway protein G; Region: typeII_sec_gspG; TIGR01710 216595000031 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 216595000032 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 216595000033 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085 216595000034 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 216595000035 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 216595000036 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085 216595000037 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 216595000038 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 216595000039 FeS/SAM binding site; other site 216595000040 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 216595000041 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085 216595000042 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 216595000043 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 216595000044 FeS/SAM binding site; other site 216595000045 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 216595000046 hypothetical protein; Provisional; Region: PRK05849 216595000047 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 216595000048 FeS/SAM binding site; other site 216595000049 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 216595000050 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 216595000051 FeS/SAM binding site; other site 216595000052 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085 216595000053 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 216595000054 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 216595000055 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 216595000056 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085 216595000057 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595000058 Walker A motif; other site 216595000059 ATP binding site [chemical binding]; other site 216595000060 Walker B motif; other site 216595000061 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216595000062 probable DNA repair protein; Region: TIGR03623 216595000063 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 216595000064 UvrD/REP helicase; Region: UvrD-helicase; cl14126 216595000065 UvrD/REP helicase; Region: UvrD-helicase; cl14126 216595000066 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 216595000067 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 216595000068 PilZ domain; Region: PilZ; cl01260 216595000069 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 216595000070 DNA replication terminus site-binding protein (Ter protein); Region: Ter; cl11502 216595000071 Bacterial protein of unknown function (DUF922); Region: DUF922; cl02415 216595000072 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 216595000073 putative active site [active] 216595000074 putative catalytic site [active] 216595000075 putative Mg binding site IVb [ion binding]; other site 216595000076 putative phosphate binding site [ion binding]; other site 216595000077 putative DNA binding site [nucleotide binding]; other site 216595000078 putative Mg binding site IVa [ion binding]; other site 216595000079 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 216595000080 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 216595000081 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595000082 UvrD/REP helicase; Region: UvrD-helicase; cl14126 216595000083 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 216595000084 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 216595000085 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 216595000086 PspA/IM30 family; Region: PspA_IM30; pfam04012 216595000087 Rhomboid family; Region: Rhomboid; cl11446 216595000088 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 216595000089 Predicted membrane protein [Function unknown]; Region: COG3766 216595000090 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 216595000091 Protein of unknown function (DUF1190); Region: DUF1190; cl10031 216595000092 Glutathionylspermidine synthase; Region: GSP_synth; cl00503 216595000093 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 216595000094 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins...; Region: Band_7_flotillin; cd03399 216595000095 ATPase involved in DNA repair; Region: DUF3686; pfam12458 216595000096 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 216595000097 MoxR-like ATPases [General function prediction only]; Region: COG0714 216595000098 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 216595000099 homodimer interface [polypeptide binding]; other site 216595000100 putative active site [active] 216595000101 catalytic site [active] 216595000102 Protein of unknown function (DUF808); Region: DUF808; cl01002 216595000103 Domain of unknown function (DUF1994); Region: DUF1994; pfam09352 216595000104 Response regulator receiver domain; Region: Response_reg; pfam00072 216595000105 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595000106 active site 216595000107 phosphorylation site [posttranslational modification] 216595000108 intermolecular recognition site; other site 216595000109 dimerization interface [polypeptide binding]; other site 216595000110 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 216595000111 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 216595000112 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 216595000113 INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183 216595000114 Phage integrase family; Region: Phage_integrase; pfam00589 216595000115 Int/Topo IB signature motif; other site 216595000116 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 216595000117 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 216595000118 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 216595000119 Phage integrase family; Region: Phage_integrase; pfam00589 216595000120 DNA binding site [nucleotide binding] 216595000121 Int/Topo IB signature motif; other site 216595000122 active site 216595000123 ParB-like nuclease domain; Region: ParBc; cl02129 216595000124 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 216595000125 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 216595000126 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 216595000127 Peptidase family M48; Region: Peptidase_M48; cl12018 216595000128 Bacterial Ig-like domain (group 1); Region: Big_1; cl10510 216595000129 ERCC4-type nuclease [DNA replication, recombination, and repair]; Region: MUS81; COG1948 216595000130 ERCC4 domain; Region: ERCC4; cl10594 216595000131 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 216595000132 Gram-negative bacterial tonB protein; Region: TonB; cl10048 216595000133 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 216595000134 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 216595000135 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 216595000136 Autotransporter beta-domain; Region: Autotransporter; cl02365 216595000137 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 216595000138 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 216595000139 homodimer interface [polypeptide binding]; other site 216595000140 putative active site [active] 216595000141 catalytic site [active] 216595000142 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes...; Region: SIRT5_Af1_CobB; cd01412 216595000143 NAD+ binding site [chemical binding]; other site 216595000144 substrate binding site [chemical binding]; other site 216595000145 Zn binding site [ion binding]; other site 216595000146 Nucleoid-associated protein [General function prediction only]; Region: COG3081 216595000147 nucleoid-associated protein NdpA; Validated; Region: PRK00378 216595000148 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 216595000149 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 216595000150 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 216595000151 Catalytic site [active] 216595000152 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 216595000153 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 216595000154 active site 216595000155 DNA binding site [nucleotide binding] 216595000156 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 216595000157 metal ion-dependent adhesion site (MIDAS); other site 216595000158 stage II sporulation protein E; Region: spore_II_E; TIGR02865 216595000159 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 216595000160 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 216595000161 substrate binding site [chemical binding]; other site 216595000162 activation loop (A-loop); other site 216595000163 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 216595000164 RNA/DNA hybrid binding site [nucleotide binding]; other site 216595000165 active site 216595000166 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 216595000167 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 216595000168 IHF dimer interface [polypeptide binding]; other site 216595000169 IHF - DNA interface [nucleotide binding]; other site 216595000170 RecD/TraA family; Region: recD_rel; TIGR01448 216595000171 AAA-like domain; Region: AAA_10; pfam12846 216595000172 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl14888 216595000173 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl14888 216595000174 TraK protein; Region: TraK; pfam06586 216595000175 type IV conjugative transfer system lipoprotein TraV; Region: TraV; TIGR02747 216595000176 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 216595000177 type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746 216595000178 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595000179 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 216595000180 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 216595000181 plasmid segregation protein ParM; Provisional; Region: PRK13917 216595000182 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 216595000183 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595000184 DNA primase (bacterial type) [DNA replication, recombination, and repair]; Region: DnaG; COG0358 216595000185 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188 216595000186 active site 216595000187 metal binding site [ion binding]; metal-binding site 216595000188 Response regulator receiver domain; Region: Response_reg; pfam00072 216595000189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595000190 active site 216595000191 phosphorylation site [posttranslational modification] 216595000192 intermolecular recognition site; other site 216595000193 dimerization interface [polypeptide binding]; other site 216595000194 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216595000195 metal binding site [ion binding]; metal-binding site 216595000196 active site 216595000197 I-site; other site 216595000198 Archaeal ATPase; Region: Arch_ATPase; pfam01637 216595000199 Protein of unknown function DUF262; Region: DUF262; cl14890 216595000200 Protein of unknown function (DUF2591); Region: DUF2591; cl11584 216595000201 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 216595000202 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 216595000203 Dtr system oriT relaxase; Provisional; Region: PRK13826 216595000204 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 216595000205 Active Sites [active] 216595000206 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 216595000207 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 216595000208 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 216595000209 allantoinase; Provisional; Region: PRK08044 216595000210 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 216595000211 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 216595000212 putative homodimer interface [polypeptide binding]; other site 216595000213 putative active site [active] 216595000214 catalytic site [active] 216595000215 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216595000216 Coenzyme A binding pocket [chemical binding]; other site 216595000217 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 216595000218 stringent starvation protein A; Provisional; Region: sspA; PRK09481 216595000219 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 216595000220 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 216595000221 N-terminal domain interface [polypeptide binding]; other site 216595000222 dimer interface [polypeptide binding]; other site 216595000223 substrate binding pocket (H-site) [chemical binding]; other site 216595000224 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 216595000225 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 216595000226 putative active site [active] 216595000227 putative substrate binding site [chemical binding]; other site 216595000228 catalytic site [active] 216595000229 dimer interface [polypeptide binding]; other site 216595000230 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 216595000231 Arc-like DNA binding domain; Region: Arc; pfam03869 216595000232 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 216595000233 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216595000234 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 216595000235 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 216595000236 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 216595000237 DNA-binding site [nucleotide binding]; DNA binding site 216595000238 RNA-binding motif; other site 216595000239 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 216595000240 HSP70 interaction site [polypeptide binding]; other site 216595000241 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 216595000242 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595000243 Protein of unknown function DUF262; Region: DUF262; cl14890 216595000244 Arc-like DNA binding domain; Region: Arc; pfam03869 216595000245 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 216595000246 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 216595000247 Active Sites [active] 216595000248 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cl14780 216595000249 UvrD/REP helicase; Region: UvrD-helicase; cl14126 216595000250 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 216595000251 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 216595000252 putative outer membrane lipoprotein; Provisional; Region: PRK10510 216595000253 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216595000254 ligand binding site [chemical binding]; other site 216595000255 Peptidase M15; Region: Peptidase_M15_3; cl01194 216595000256 DNA ligase; Provisional; Region: 30; PHA02587 216595000257 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cd06846 216595000258 active site 216595000259 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 216595000260 DNA binding site [nucleotide binding] 216595000261 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 216595000262 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 216595000263 dimer interface [polypeptide binding]; other site 216595000264 ssDNA binding site [nucleotide binding]; other site 216595000265 tetramer (dimer of dimers) interface [polypeptide binding]; other site 216595000266 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cl14780 216595000267 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 216595000268 Response regulator receiver domain; Region: Response_reg; pfam00072 216595000269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595000270 active site 216595000271 phosphorylation site [posttranslational modification] 216595000272 intermolecular recognition site; other site 216595000273 dimerization interface [polypeptide binding]; other site 216595000274 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 216595000275 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 216595000276 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 216595000277 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 216595000278 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 216595000279 alkylmercury lyase; Provisional; Region: PRK13239 216595000280 Helix-turn-helix domain of alkylmercury lyase; Region: HTH_15; pfam12324 216595000281 Alkylmercury lyase; Region: MerB; pfam03243 216595000282 putative mercuric reductase; Provisional; Region: PRK13748 216595000283 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 216595000284 metal-binding site [ion binding] 216595000285 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595000286 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 216595000287 MerC mercury resistance protein; Region: MerC; cl03934 216595000288 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 216595000289 metal-binding site [ion binding] 216595000290 MerT mercuric transport protein; Region: MerT; cl03578 216595000291 putative transcriptional regulator MerR; Provisional; Region: PRK13752 216595000292 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 216595000293 DNA binding residues [nucleotide binding] 216595000294 dimer interface [polypeptide binding]; other site 216595000295 mercury binding site [ion binding]; other site 216595000296 Putative exonuclease, RdgC; Region: RdgC; cl01122 216595000297 Global regulator protein family; Region: CsrA; cl00670 216595000298 ParB-like nuclease domain; Region: ParBc; cl02129 216595000299 PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734 216595000300 PRTRC system protein E; Region: PRTRC_E; TIGR03741 216595000301 PRTRC system ThiF family protein; Region: PRTRC_ThiF; TIGR03736 216595000302 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 216595000303 ATP binding site [chemical binding]; other site 216595000304 substrate interface [chemical binding]; other site 216595000305 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 216595000306 active site 216595000307 catalytic site [active] 216595000308 substrate binding site [chemical binding]; other site 216595000309 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 216595000310 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 216595000311 DNA polymerase III beta subunit; Region: POL3Bc; smart00480 216595000312 putative DNA binding surface [nucleotide binding]; other site 216595000313 dimer interface [polypeptide binding]; other site 216595000314 beta-clamp/clamp loader binding surface; other site 216595000315 beta-clamp/translesion DNA polymerase binding surface; other site 216595000316 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 216595000317 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 216595000318 CheB methylesterase; Region: CheB_methylest; pfam01339 216595000319 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 216595000320 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 216595000321 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216595000322 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595000323 ATP binding site [chemical binding]; other site 216595000324 Mg2+ binding site [ion binding]; other site 216595000325 G-X-G motif; other site 216595000326 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 216595000327 Response regulator receiver domain; Region: Response_reg; pfam00072 216595000328 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595000329 active site 216595000330 phosphorylation site [posttranslational modification] 216595000331 intermolecular recognition site; other site 216595000332 dimerization interface [polypeptide binding]; other site 216595000333 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 216595000334 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 216595000335 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595000336 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595000337 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 216595000338 Response regulator receiver domain; Region: Response_reg; pfam00072 216595000339 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595000340 active site 216595000341 phosphorylation site [posttranslational modification] 216595000342 intermolecular recognition site; other site 216595000343 dimerization interface [polypeptide binding]; other site 216595000344 ParB-like partition proteins; Region: parB_part; TIGR00180 216595000345 ParB-like nuclease domain; Region: ParBc; cl02129 216595000346 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 216595000347 hypothetical protein; Validated; Region: PRK06672 216595000348 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595000349 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 216595000350 Walker A motif; other site 216595000351 ATP binding site [chemical binding]; other site 216595000352 Walker B motif; other site 216595000353 arginine finger; other site 216595000354 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 216595000355 DnaA box-binding interface [nucleotide binding]; other site 216595000357 PS00017 ATP/GTP-binding site motif A (P-loop). 216595000359 PS01008 DnaA protein signature. 216595000360 DNA polymerase III subunit beta; Validated; Region: PRK05643 216595000361 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 216595000362 putative DNA binding surface [nucleotide binding]; other site 216595000363 dimer interface [polypeptide binding]; other site 216595000364 beta-clamp/clamp loader binding surface; other site 216595000365 beta-clamp/translesion DNA polymerase binding surface; other site 216595000369 recombination protein F; Reviewed; Region: recF; PRK00064 216595000370 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595000371 Walker A/P-loop; other site 216595000372 ATP binding site [chemical binding]; other site 216595000373 Q-loop/lid; other site 216595000374 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595000375 ABC transporter signature motif; other site 216595000376 Walker B; other site 216595000377 D-loop; other site 216595000378 H-loop/switch region; other site 216595000380 PS00017 ATP/GTP-binding site motif A (P-loop). 216595000381 PS00617 RecF protein signature 1. 216595000382 PS00618 RecF protein signature 2. 216595000383 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 216595000384 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 216595000385 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 216595000386 anchoring element; other site 216595000387 dimer interface [polypeptide binding]; other site 216595000388 ATP binding site [chemical binding]; other site 216595000389 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 216595000390 active site 216595000391 putative metal-binding site [ion binding]; other site 216595000392 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 216595000396 PS00177 DNA topoisomerase II signature. 216595000398 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216595000399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595000400 active site 216595000401 phosphorylation site [posttranslational modification] 216595000402 intermolecular recognition site; other site 216595000403 dimerization interface [polypeptide binding]; other site 216595000404 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 216595000405 DNA binding site [nucleotide binding] 216595000407 PS00310 Lysosome-associated membrane glycoproteins duplicated domain signature. 216595000409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254 216595000410 FecR protein; Region: FecR; pfam04773 216595000412 CHASE2 domain; Region: CHASE2; cl01732 216595000413 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 216595000414 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 216595000415 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 216595000416 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595000417 ATP binding site [chemical binding]; other site 216595000418 Mg2+ binding site [ion binding]; other site 216595000419 G-X-G motif; other site 216595000420 4 probable transmembrane helices predicted for PFLU0007 by TMHMM2.0 at aa 26-48, 305-327, 332-351 and 356-375 216595000422 PS00215 Mitochondrial energy transfer proteins signature. 216595000426 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 216595000427 putative acyl-acceptor binding pocket; other site 216595000429 1 probable transmembrane helix predicted for PFLU0008 by TMHMM2.0 at aa 46-68 216595000430 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 216595000431 active site 216595000432 motif I; other site 216595000433 motif II; other site 216595000435 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 216595000436 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 216595000437 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 216595000440 glycyl-tRNA synthetase, tetrameric type, alpha subunit; Region: glyQ; TIGR00388 216595000441 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 216595000442 dimer interface [polypeptide binding]; other site 216595000443 motif 1; other site 216595000444 active site 216595000445 motif 2; other site 216595000446 motif 3; other site 216595000448 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216595000449 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 216595000451 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 216595000452 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 216595000453 putative acyl-acceptor binding pocket; other site 216595000457 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 216595000458 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595000459 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 216595000460 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595000461 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 216595000466 16S rRNA methyltransferase B; Provisional; Region: PRK10901 216595000467 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 216595000468 putative RNA binding site [nucleotide binding]; other site 216595000469 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 216595000472 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 216595000473 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 216595000474 putative active site [active] 216595000475 substrate binding site [chemical binding]; other site 216595000476 putative cosubstrate binding site; other site 216595000477 catalytic site [active] 216595000478 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 216595000479 substrate binding site [chemical binding]; other site 216595000482 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 216595000483 active site 216595000484 catalytic residues [active] 216595000485 metal binding site [ion binding]; metal-binding site 216595000487 PS00017 ATP/GTP-binding site motif A (P-loop). 216595000488 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 216595000489 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 216595000491 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 216595000493 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 216595000494 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 216595000495 NADP binding site [chemical binding]; other site 216595000496 dimer interface [polypeptide binding]; other site 216595000498 PS01162 Quinone oxidoreductase / zeta-crystallin signature. 216595000500 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 216595000502 PS01021 Coproporphyrinogen III oxidase signature. 216595000503 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 216595000504 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 216595000505 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 216595000506 shikimate binding site; other site 216595000507 NAD(P) binding site [chemical binding]; other site 216595000510 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 216595000511 Sulfate transporter family; Region: Sulfate_transp; cl00967 216595000512 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 216595000515 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 216595000516 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 216595000518 Sulfatase; Region: Sulfatase; cl10460 216595000519 choline-sulfatase; Region: chol_sulfatase; TIGR03417 216595000520 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 216595000522 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 216595000523 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595000524 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595000525 dimerization interface [polypeptide binding]; other site 216595000527 PS00044 Bacterial regulatory proteins, lysR family signature. 216595000529 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; cl01562 216595000531 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 216595000532 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 216595000534 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 216595000535 active site 216595000536 intersubunit interface [polypeptide binding]; other site 216595000537 catalytic residue [active] 216595000539 PS00160 KDPG and KHG aldolases Schiff-base forming residue. 216595000540 galactonate dehydratase; Provisional; Region: PRK14017 216595000541 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 216595000542 putative active site pocket [active] 216595000543 putative metal binding site [ion binding]; other site 216595000545 PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1. 216595000547 PS00909 Mandelate racemase / muconate lactonizing enzyme family signature 2. 216595000548 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595000549 D-galactonate transporter; Region: 2A0114; TIGR00893 216595000550 putative substrate translocation pore; other site 216595000551 11 probable transmembrane helices predicted for PFLU0033 by TMHMM2.0 at aa 20-35, 56-78, 93-115, 146-168, 173-195, 246-268, 283-302, 315-337, 342-364, 377-399 and 404-426 216595000553 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 216595000554 tryptophan synthase; Region: PLN02591 216595000555 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724 216595000556 substrate binding site [chemical binding]; other site 216595000557 active site 216595000558 catalytic residues [active] 216595000559 heterodimer interface [polypeptide binding]; other site 216595000561 PS00201 Flavodoxin signature. 216595000562 PS00167 Tryptophan synthase alpha chain signature. 216595000563 tryptophan synthase, beta chain; Region: PLN02618 216595000564 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 216595000565 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595000566 catalytic residue [active] 216595000568 PS00168 Tryptophan synthase beta chain pyridoxal-phosphate attachment site. 216595000569 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 216595000570 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595000571 The C-terminal substrate binding domain of LysR-type transcriptional regulator TrpI, which is involved in control of tryptophan synthesis, contains type 2 periplasmic binding fold; Region: PBP2_TrpI; cd08482 216595000572 putative dimerization interface [polypeptide binding]; other site 216595000573 putative substrate binding pocket [chemical binding]; other site 216595000575 PS00044 Bacterial regulatory proteins, lysR family signature. 216595000577 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 216595000579 1 probable transmembrane helix predicted for PFLU0038 by TMHMM2.0 at aa 85-104 216595000580 Protein of unknown function (DUF1458); Region: DUF1458; cl01328 216595000582 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 216595000584 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 216595000585 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 216595000587 OsmC-like protein; Region: OsmC; cl00767 216595000589 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 216595000591 PS00443 Glutamine amidotransferases class-II active site. 216595000592 Predicted aminopeptidase [General function prediction only]; Region: COG4324 216595000593 Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023 216595000594 1 probable transmembrane helix predicted for PFLU0045 by TMHMM2.0 at aa 33-55 216595000595 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595000596 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 216595000597 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 216595000598 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 216595000599 motif II; other site 216595000601 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 216595000602 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 216595000603 trimer interface [polypeptide binding]; other site 216595000604 putative metal binding site [ion binding]; other site 216595000610 oligopeptidase A; Provisional; Region: PRK10911 216595000611 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 216595000612 active site 216595000613 Zn binding site [ion binding]; other site 216595000615 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 216595000616 Probable metal-binding protein (DUF2387); Region: DUF2387; cl01410 216595000617 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 216595000619 PS00383 Tyrosine specific protein phosphatases active site. 216595000620 1 probable transmembrane helix predicted for PFLU0051 by TMHMM2.0 at aa 17-39 216595000621 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 216595000622 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 216595000624 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 216595000625 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 216595000626 Cytochrome c; Region: Cytochrom_C; cl11414 216595000627 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595000628 PS00190 Cytochrome c family heme-binding site signature. 216595000629 PS00190 Cytochrome c family heme-binding site signature. 216595000631 PS00190 Cytochrome c family heme-binding site signature. 216595000632 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 216595000633 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 216595000635 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 216595000636 active site clefts [active] 216595000637 zinc binding site [ion binding]; other site 216595000638 dimer interface [polypeptide binding]; other site 216595000640 PS00704 Prokaryotic-type carbonic anhydrases signature 1. 216595000641 PS00705 Prokaryotic-type carbonic anhydrases signature 2. 216595000642 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 216595000643 Sulfate transporter family; Region: Sulfate_transp; cl00967 216595000644 10 probable transmembrane helices predicted for PFLU0056 by TMHMM2.0 at aa 15-37, 44-66, 81-103, 115-137, 152-174, 195-217, 246-268, 288-310, 325-356 and 377-399 216595000646 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00051 216595000647 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 216595000648 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 216595000649 Cytochrome c [Energy production and conversion]; Region: COG3258 216595000650 Cytochrome c; Region: Cytochrom_C; cl11414 216595000651 3 probable transmembrane helices predicted for PFLU0058 by TMHMM2.0 at aa 7-29, 44-66 and 87-104 216595000654 PS00078 CO II and nitrous oxide reductase dinuclear copper centers signature. 216595000656 PS00190 Cytochrome c family heme-binding site signature. 216595000657 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 216595000658 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 216595000659 Subunit I/III interface [polypeptide binding]; other site 216595000660 D-pathway; other site 216595000661 Subunit I/VIIc interface [polypeptide binding]; other site 216595000662 Subunit I/IV interface [polypeptide binding]; other site 216595000663 Subunit I/II interface [polypeptide binding]; other site 216595000664 Low-spin heme (heme a) binding site [chemical binding]; other site 216595000665 Subunit I/VIIa interface [polypeptide binding]; other site 216595000666 Subunit I/VIa interface [polypeptide binding]; other site 216595000667 Dimer interface; other site 216595000668 Putative water exit pathway; other site 216595000669 Binuclear center (heme a3/CuB) [ion binding]; other site 216595000670 K-pathway; other site 216595000671 Subunit I/Vb interface [polypeptide binding]; other site 216595000672 Putative proton exit pathway; other site 216595000673 Subunit I/VIb interface; other site 216595000674 Subunit I/VIc interface [polypeptide binding]; other site 216595000675 Electron transfer pathway; other site 216595000676 Subunit I/VIIIb interface [polypeptide binding]; other site 216595000677 Subunit I/VIIb interface [polypeptide binding]; other site 216595000679 12 probable transmembrane helices predicted for PFLU0059 by TMHMM2.0 at aa 33-55, 75-97, 117-139, 159-181, 201-223, 252-274, 281-303, 318-340, 353-375, 390-412, 429-451 and 466-488 216595000680 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595000681 PS00077 Heme-copper oxidase catalytic subunit, copper B binding region signature. 216595000682 Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; cl01240 216595000683 1 probable transmembrane helix predicted for PFLU0060 by TMHMM2.0 at aa 49-71 216595000685 PS00017 ATP/GTP-binding site motif A (P-loop). 216595000686 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 216595000687 Subunit III/VIIa interface [polypeptide binding]; other site 216595000688 Phospholipid binding site [chemical binding]; other site 216595000689 Subunit I/III interface [polypeptide binding]; other site 216595000690 Subunit III/VIb interface [polypeptide binding]; other site 216595000691 Subunit III/VIa interface; other site 216595000692 Subunit III/Vb interface [polypeptide binding]; other site 216595000693 6 probable transmembrane helices predicted for PFLU0061 by TMHMM2.0 at aa 15-34, 46-68, 88-110, 191-213, 233-255 and 275-294 216595000695 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 216595000696 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 216595000697 2 probable transmembrane helices predicted for PFLU0063 by TMHMM2.0 at aa 15-37 and 214-236 216595000698 1 probable transmembrane helix predicted for PFLU0064 by TMHMM2.0 at aa 21-43 216595000699 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 216595000701 8 probable transmembrane helices predicted for PFLU0065 by TMHMM2.0 at aa 7-29, 75-97, 110-129, 144-166, 173-192, 245-267, 274-296 and 300-322 216595000702 PS00699 Nitrogenases component 1 alpha and beta subunits signature 1. 216595000703 UbiA prenyltransferase family; Region: UbiA; cl00337 216595000704 9 probable transmembrane helices predicted for PFLU0066 by TMHMM2.0 at aa 25-44, 49-71, 92-114, 119-139, 146-165, 169-191, 218-237, 242-264 and 277-296 216595000706 PS00943 UbiA prenyltransferase family signature. 216595000707 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 216595000708 Cu(I) binding site [ion binding]; other site 216595000709 1 probable transmembrane helix predicted for PFLU0067 by TMHMM2.0 at aa 7-29 216595000711 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 216595000713 PS00430 TonB-dependent receptor proteins signature 1. 216595000714 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595000715 dimer interface [polypeptide binding]; other site 216595000716 conserved gate region; other site 216595000717 ABC-ATPase subunit interface; other site 216595000719 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595000720 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 216595000721 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein; Region: ABC_MetN_methionine_transporter; cd03258 216595000722 Walker A/P-loop; other site 216595000723 ATP binding site [chemical binding]; other site 216595000724 Q-loop/lid; other site 216595000725 ABC transporter signature motif; other site 216595000726 Walker B; other site 216595000727 D-loop; other site 216595000728 H-loop/switch region; other site 216595000729 NIL domain; Region: NIL; cl09633 216595000731 PS00211 ABC transporters family signature. 216595000732 PS00017 ATP/GTP-binding site motif A (P-loop). 216595000733 hydroperoxidase II; Provisional; Region: katE; PRK11249 216595000734 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 216595000735 tetramer interface [polypeptide binding]; other site 216595000736 heme binding pocket [chemical binding]; other site 216595000737 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 216595000738 domain interactions; other site 216595000740 PS00438 Catalase proximal active site signature. 216595000741 PS00437 Catalase proximal heme-ligand signature. 216595000744 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595000745 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 216595000746 ABC-ATPase subunit interface; other site 216595000747 dimer interface [polypeptide binding]; other site 216595000748 putative PBP binding regions; other site 216595000750 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 216595000751 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 216595000753 PS00211 ABC transporters family signature. 216595000754 PS00017 ATP/GTP-binding site motif A (P-loop). 216595000755 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 216595000756 metal binding site 2 [ion binding]; metal-binding site 216595000757 putative DNA binding helix; other site 216595000758 metal binding site 1 [ion binding]; metal-binding site 216595000759 dimer interface [polypeptide binding]; other site 216595000760 structural Zn2+ binding site [ion binding]; other site 216595000761 PS00190 Cytochrome c family heme-binding site signature. 216595000762 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 216595000763 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 216595000764 metal binding site [ion binding]; metal-binding site 216595000767 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 216595000768 putative active site [active] 216595000769 putative substrate binding site [chemical binding]; other site 216595000770 ATP binding site [chemical binding]; other site 216595000772 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 216595000773 DNA polymerase I; Provisional; Region: PRK05755 216595000774 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 216595000775 active site 216595000776 metal binding site 1 [ion binding]; metal-binding site 216595000777 putative 5' ssDNA interaction site; other site 216595000778 metal binding site 3; metal-binding site 216595000779 metal binding site 2 [ion binding]; metal-binding site 216595000780 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 216595000781 putative DNA binding site [nucleotide binding]; other site 216595000782 putative metal binding site [ion binding]; other site 216595000783 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 216595000784 active site 216595000785 catalytic site [active] 216595000786 substrate binding site [chemical binding]; other site 216595000787 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 216595000788 active site 216595000789 DNA binding site [nucleotide binding] 216595000790 catalytic site [active] 216595000795 PS00447 DNA polymerase family A signature. 216595000796 The YihA (EngB) subfamily. This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876 216595000797 G1 box; other site 216595000798 GTP/Mg2+ binding site [chemical binding]; other site 216595000799 Switch I region; other site 216595000800 G2 box; other site 216595000801 G3 box; other site 216595000802 Switch II region; other site 216595000803 G4 box; other site 216595000804 G5 box; other site 216595000806 PS00017 ATP/GTP-binding site motif A (P-loop). 216595000807 Cytochrome c; Region: Cytochrom_C; cl11414 216595000808 PS00190 Cytochrome c family heme-binding site signature. 216595000809 Cytochrome c; Region: Cytochrom_C; cl11414 216595000810 Cytochrome c; Region: Cytochrom_C; cl11414 216595000812 PS00190 Cytochrome c family heme-binding site signature. 216595000814 PS00190 Cytochrome c family heme-binding site signature. 216595000815 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 216595000816 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 216595000817 catalytic residues [active] 216595000818 hinge region; other site 216595000819 alpha helical domain; other site 216595000821 PS00194 Thioredoxin family active site. 216595000822 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 216595000823 putative catalytic site [active] 216595000824 putative metal binding site [ion binding]; other site 216595000825 putative phosphate binding site [ion binding]; other site 216595000827 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216595000828 metal binding site [ion binding]; metal-binding site 216595000829 active site 216595000830 I-site; other site 216595000832 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 216595000833 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 216595000834 amidase catalytic site [active] 216595000835 Zn binding residues [ion binding]; other site 216595000836 substrate binding site [chemical binding]; other site 216595000837 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 216595000838 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595000841 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 216595000842 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595000843 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 216595000844 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 216595000845 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595000846 dimer interface [polypeptide binding]; other site 216595000847 phosphorylation site [posttranslational modification] 216595000848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595000849 ATP binding site [chemical binding]; other site 216595000850 Mg2+ binding site [ion binding]; other site 216595000851 G-X-G motif; other site 216595000856 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 216595000857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595000858 active site 216595000859 phosphorylation site [posttranslational modification] 216595000860 intermolecular recognition site; other site 216595000861 dimerization interface [polypeptide binding]; other site 216595000862 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595000863 Walker A motif; other site 216595000864 ATP binding site [chemical binding]; other site 216595000865 Walker B motif; other site 216595000866 arginine finger; other site 216595000867 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 216595000869 PS00688 Sigma-54 interaction domain C-terminal part signature. 216595000871 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 216595000872 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 216595000875 2 probable transmembrane helices predicted for PFLU0090 by TMHMM2.0 at aa 2-24 and 29-48 216595000876 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; cl07428 216595000878 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 216595000879 8 probable transmembrane helices predicted for PFLU0093 by TMHMM2.0 at aa 7-29, 49-71, 84-106, 154-176, 205-227, 232-254, 320-342 and 362-384 216595000881 PS00713 Sodium:dicarboxylate symporter family signature 1. 216595000882 PS00714 Sodium:dicarboxylate symporter family signature 2. 216595000883 Nucleoside recognition; Region: Gate; cl00486 216595000884 Nucleoside recognition; Region: Gate; cl00486 216595000885 9 probable transmembrane helices predicted for PFLU0094 by TMHMM2.0 at aa 2-24, 39-61, 140-162, 172-194, 203-225, 230-252, 278-297, 357-379 and 386-408 216595000887 PS00012 Phosphopantetheine attachment site. 216595000889 Protein of unknown function (DUF330); Region: DUF330; cl01135 216595000890 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595000891 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 216595000892 mce related protein; Region: MCE; pfam02470 216595000894 1 probable transmembrane helix predicted for PFLU0096 by TMHMM2.0 at aa 20-39 216595000895 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 216595000896 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595000897 Walker A/P-loop; other site 216595000898 ATP binding site [chemical binding]; other site 216595000899 Q-loop/lid; other site 216595000900 ABC transporter signature motif; other site 216595000901 Walker B; other site 216595000902 D-loop; other site 216595000903 H-loop/switch region; other site 216595000904 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 216595000906 PS00211 ABC transporters family signature. 216595000907 PS00017 ATP/GTP-binding site motif A (P-loop). 216595000908 Domain of unknown function DUF140; Region: DUF140; cl00510 216595000910 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 216595000911 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 216595000912 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 216595000913 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 216595000914 1 probable transmembrane helix predicted for PFLU0100 by TMHMM2.0 at aa 433-455 216595000917 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 216595000918 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 216595000920 Integral membrane protein TerC family; Region: TerC; cl10468 216595000922 Citrate transporter; Region: CitMHS; pfam03600 216595000923 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 216595000924 transmembrane helices; other site 216595000927 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 216595000928 Protein of unknown function (DUF2388); Region: DUF2388; cl09731 216595000929 Protein of unknown function (DUF2388); Region: DUF2388; cl09731 216595000930 1 probable transmembrane helix predicted for PFLU0106 by TMHMM2.0 at aa 24-46 216595000931 Protein of unknown function (DUF2388); Region: DUF2388; cl09731 216595000932 1 probable transmembrane helix predicted for PFLU0107 by TMHMM2.0 at aa 29-51 216595000933 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 216595000935 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 216595000936 succinate CoA transferases; Region: YgfH_subfam; TIGR03458 216595000937 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 216595000939 NAD(P) transhydrogenase beta subunit; Region: PNTB; cl00566 216595000941 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 216595000942 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 216595000943 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 216595000944 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 216595000947 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 216595000948 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595000949 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 216595000950 dimerization interface [polypeptide binding]; other site 216595000951 substrate binding pocket [chemical binding]; other site 216595000953 PS00430 TonB-dependent receptor proteins signature 1. 216595000955 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 216595000956 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216595000957 FAD binding site [chemical binding]; other site 216595000958 substrate binding pocket [chemical binding]; other site 216595000959 catalytic base [active] 216595000963 PS00073 Acyl-CoA dehydrogenases signature 2. 216595000964 CoA-transferase family III; Region: CoA_transf_3; cl00778 216595000966 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595000967 Cache domain; Region: Cache_1; pfam02743 216595000968 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 216595000969 dimerization interface [polypeptide binding]; other site 216595000970 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595000971 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595000972 2 probable transmembrane helices predicted for PFLU0117 by TMHMM2.0 at aa 51-73 and 318-340 216595000977 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 216595000978 putative hydrophobic ligand binding site [chemical binding]; other site 216595000979 protein interface [polypeptide binding]; other site 216595000980 gate; other site 216595000981 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216595000982 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595000983 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595000984 Phosphopantetheine attachment site; Region: PP-binding; cl09936 216595000985 thioester reductase domain; Region: Thioester-redct; TIGR01746 216595000986 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 216595000987 putative NAD(P) binding site [chemical binding]; other site 216595000988 active site 216595000989 putative substrate binding site [chemical binding]; other site 216595000992 PS00307 Legume lectins beta-chain signature. 216595000994 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 216595000995 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 216595000996 Transcriptional regulators [Transcription]; Region: GntR; COG1802 216595000997 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595000998 DNA-binding site [nucleotide binding]; DNA binding site 216595000999 FCD domain; Region: FCD; cl11656 216595001002 PS00527 Ribosomal protein S14 signature. 216595001003 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 216595001004 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 216595001006 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 216595001007 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 216595001009 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 216595001010 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 216595001011 Walker A/P-loop; other site 216595001012 ATP binding site [chemical binding]; other site 216595001013 Q-loop/lid; other site 216595001014 ABC transporter signature motif; other site 216595001015 Walker B; other site 216595001016 D-loop; other site 216595001017 H-loop/switch region; other site 216595001019 PS00017 ATP/GTP-binding site motif A (P-loop). 216595001020 PS00211 ABC transporters family signature. 216595001021 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 216595001022 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 216595001024 6 probable transmembrane helices predicted for PFLU0126 by TMHMM2.0 at aa 86-108, 123-142, 147-169, 189-211, 216-238 and 248-267 216595001025 Gram-negative bacterial tonB protein; Region: TonB; cl10048 216595001026 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 216595001027 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595001028 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 216595001029 putative substrate binding pocket [chemical binding]; other site 216595001030 putative dimerization interface [polypeptide binding]; other site 216595001032 PS00044 Bacterial regulatory proteins, lysR family signature. 216595001034 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 216595001035 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595001036 14 probable transmembrane helices predicted for PFLU0129 by TMHMM2.0 at aa 21-43, 67-89, 96-115, 125-147, 152-174, 184-204, 217-239, 244-266, 287-309, 324-346, 353-375, 385-407, 414-436 and 482-499 216595001038 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 216595001039 1 probable transmembrane helix predicted for PFLU0130 by TMHMM2.0 at aa 12-34 216595001041 NodT family; Region: outer_NodT; TIGR01845 216595001042 Outer membrane efflux protein; Region: OEP; pfam02321 216595001043 Outer membrane efflux protein; Region: OEP; pfam02321 216595001044 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595001047 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 216595001048 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 216595001049 PS00017 ATP/GTP-binding site motif A (P-loop). 216595001050 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 216595001051 8 probable transmembrane helices predicted for PFLU0134 by TMHMM2.0 at aa 32-54, 100-122, 153-172, 192-214, 226-243, 288-310, 322-344 and 370-389 216595001053 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 216595001055 Transcriptional regulators [Transcription]; Region: MarR; COG1846 216595001056 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595001058 Fusaric acid resistance protein family; Region: FUSC; pfam04632 216595001059 Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136 216595001060 Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136 216595001061 10 probable transmembrane helices predicted for PFLU0137 by TMHMM2.0 at aa 15-33, 61-83, 87-104, 111-130, 145-162, 367-389, 394-411, 418-440, 450-472 and 495-517 216595001063 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 216595001065 2 probable transmembrane helices predicted for PFLU0138 by TMHMM2.0 at aa 10-32 and 41-60 216595001066 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 216595001067 1 probable transmembrane helix predicted for PFLU0139 by TMHMM2.0 at aa 7-29 216595001069 NodT family; Region: outer_NodT; TIGR01845 216595001070 Outer membrane efflux protein; Region: OEP; pfam02321 216595001071 Outer membrane efflux protein; Region: OEP; pfam02321 216595001072 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595001075 2 probable transmembrane helices predicted for PFLU0141 by TMHMM2.0 at aa 13-35 and 45-67 216595001076 hypothetical protein; Provisional; Region: PRK11367 216595001077 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 216595001079 1 probable transmembrane helix predicted for PFLU0142 by TMHMM2.0 at aa 5-27 216595001080 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 216595001081 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 216595001082 binding surface 216595001083 TPR motif; other site 216595001085 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 216595001086 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 216595001087 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595001089 N-glycosyltransferase; Provisional; Region: PRK11204 216595001090 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 216595001091 DXD motif; other site 216595001092 5 probable transmembrane helices predicted for PFLU0145 by TMHMM2.0 at aa 13-35, 39-61, 327-349, 369-388 and 401-423 216595001094 hemin storage system protein; Provisional; Region: hmsS; cl14676 216595001095 2 probable transmembrane helices predicted for PFLU0146 by TMHMM2.0 at aa 13-35 and 55-77 216595001096 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 216595001097 Surface antigen; Region: Bac_surface_Ag; cl03097 216595001100 haemagglutination activity domain; Region: Haemagg_act; cl05436 216595001101 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 216595001110 PS00017 ATP/GTP-binding site motif A (P-loop). 216595001114 PFI-1 216595001115 Transposase IS200 like; Region: Y1_Tnp; cl00848 216595001117 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 216595001118 4 probable transmembrane helices predicted for PFLU0154 by TMHMM2.0 at aa 6-25, 30-52, 57-79 and 92-114 216595001119 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 216595001120 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 216595001121 Catalytic site [active] 216595001123 PS00760 Signal peptidases I lysine active site. 216595001124 PS00761 Signal peptidases I signature 3. 216595001125 3 probable transmembrane helices predicted for PFLU0155 by TMHMM2.0 at aa 21-40, 45-67 and 79-101 216595001126 RDD family; Region: RDD; cl00746 216595001128 2 probable transmembrane helices predicted for PFLU0156 by TMHMM2.0 at aa 20-37 and 47-69 216595001129 RDD family; Region: RDD; cl00746 216595001130 2 probable transmembrane helices predicted for PFLU0157 by TMHMM2.0 at aa 20-37 and 50-72 216595001131 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595001132 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595001133 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595001134 Curli production assembly/transport component CsgG; Region: CsgG; cl00639 216595001136 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595001137 PS00017 ATP/GTP-binding site motif A (P-loop). 216595001138 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 216595001139 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595001140 Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813 216595001142 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595001143 PS00296 Chaperonins cpn60 signature. 216595001144 von Willebrand factor; Region: vWF_A; pfam12450 216595001145 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 216595001146 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-...; Region: vWA_subgroup; cd01465 216595001147 metal ion-dependent adhesion site (MIDAS); other site 216595001148 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 216595001150 PS00435 Peroxidases proximal heme-ligand signature. 216595001151 PS00584 pfkB family of carbohydrate kinases signature 2. 216595001152 RNA polymerase sigma factor; Provisional; Region: PRK12513 216595001153 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216595001154 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 216595001155 DNA binding residues [nucleotide binding] 216595001158 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2; cl00195 216595001159 Domain of unknown function DUF87; Region: DUF87; pfam01935 216595001160 HerA helicase [Replication, recombination, and repair]; Region: COG0433 216595001162 PS00017 ATP/GTP-binding site motif A (P-loop). 216595001163 CHAT domain; Region: CHAT; cl02083 216595001164 chromosome segregation protein; Provisional; Region: PRK02224 216595001165 hypothetical protein; Validated; Region: PRK07078 216595001166 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication...; Region: TOPRIM_primases; cd01029 216595001167 active site 216595001168 metal binding site [ion binding]; metal-binding site 216595001169 interdomain interaction site; other site 216595001170 Domain of unknown function (DUF927); Region: DUF927; cl12098 216595001171 PS00017 ATP/GTP-binding site motif A (P-loop). 216595001172 Protein of unknown function (DUF3077); Region: DUF3077; pfam11275 216595001173 1 probable transmembrane helix predicted for PFLU0177 by TMHMM2.0 at aa 52-74 216595001174 integrase; Provisional; Region: PRK09692 216595001175 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 216595001176 active site 216595001177 Int/Topo IB signature motif; other site 216595001179 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216595001180 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 216595001181 tetramerization interface [polypeptide binding]; other site 216595001182 NAD(P) binding site [chemical binding]; other site 216595001183 catalytic residues [active] 216595001185 PS00687 Aldehyde dehydrogenases glutamic acid active site. 216595001186 PS00070 Aldehyde dehydrogenases cysteine active site. 216595001187 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 216595001188 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 216595001189 inhibitor-cofactor binding pocket; inhibition site 216595001190 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595001191 catalytic residue [active] 216595001193 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 216595001194 Response regulator receiver domain; Region: Response_reg; pfam00072 216595001195 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595001196 active site 216595001197 phosphorylation site [posttranslational modification] 216595001198 intermolecular recognition site; other site 216595001199 dimerization interface [polypeptide binding]; other site 216595001200 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 216595001203 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216595001204 PAS fold; Region: PAS_3; pfam08447 216595001205 putative active site [active] 216595001206 heme pocket [chemical binding]; other site 216595001207 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216595001208 metal binding site [ion binding]; metal-binding site 216595001209 active site 216595001210 I-site; other site 216595001213 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 216595001214 Di-iron ligands [ion binding]; other site 216595001215 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 216595001217 PAS domain S-box; Region: sensory_box; TIGR00229 216595001218 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216595001219 putative active site [active] 216595001220 heme pocket [chemical binding]; other site 216595001221 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216595001222 metal binding site [ion binding]; metal-binding site 216595001223 active site 216595001224 I-site; other site 216595001225 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216595001229 Uncharacterized small protein (DUF2292); Region: DUF2292; cl02371 216595001230 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595001232 PS00757 Prokaryotic sulfate-binding proteins signature 2. 216595001233 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 216595001234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595001235 dimer interface [polypeptide binding]; other site 216595001236 conserved gate region; other site 216595001237 putative PBP binding loops; other site 216595001238 ABC-ATPase subunit interface; other site 216595001239 6 probable transmembrane helices predicted for PFLU0188 by TMHMM2.0 at aa 12-34, 63-85, 98-120, 135-157, 183-205 and 243-265 216595001241 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595001242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595001243 dimer interface [polypeptide binding]; other site 216595001244 conserved gate region; other site 216595001245 putative PBP binding loops; other site 216595001246 ABC-ATPase subunit interface; other site 216595001247 6 probable transmembrane helices predicted for PFLU0189 by TMHMM2.0 at aa 25-47, 72-94, 107-129, 144-166, 205-227 and 250-272 216595001249 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595001250 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 216595001251 Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a solute-...; Region: ABC_CysA_sulfate_importer; cd03296 216595001252 Walker A/P-loop; other site 216595001253 ATP binding site [chemical binding]; other site 216595001254 Q-loop/lid; other site 216595001255 ABC transporter signature motif; other site 216595001256 Walker B; other site 216595001257 D-loop; other site 216595001258 H-loop/switch region; other site 216595001259 TOBE-like domain; Region: TOBE_3; pfam12857 216595001261 PS00017 ATP/GTP-binding site motif A (P-loop). 216595001262 PS00211 ABC transporters family signature. 216595001263 Protein of unknown function (DUF962); Region: DUF962; cl01879 216595001265 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 216595001266 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216595001267 ligand binding site [chemical binding]; other site 216595001268 flexible hinge region; other site 216595001269 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 216595001270 putative switch regulator; other site 216595001271 non-specific DNA interactions [nucleotide binding]; other site 216595001272 DNA binding site [nucleotide binding] 216595001273 sequence specific DNA binding site [nucleotide binding]; other site 216595001274 putative cAMP binding site [chemical binding]; other site 216595001277 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU)...; Region: TLP_HIUase; cd05822 216595001278 active site 216595001279 homotetramer interface [polypeptide binding]; other site 216595001281 PS00769 Transthyretin signature 2. 216595001282 Domain of unknown function (DUF336); Region: DUF336; cl01249 216595001285 PS00430 TonB-dependent receptor proteins signature 1. 216595001286 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 216595001287 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595001289 Fatty acid desaturase; Region: FA_desaturase; pfam00487 216595001290 3 probable transmembrane helices predicted for PFLU0197 by TMHMM2.0 at aa 43-65, 189-211 and 231-253 216595001291 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 216595001292 Sulfatase; Region: Sulfatase; cl10460 216595001294 PS00523 Sulfatases signature 1. 216595001295 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 216595001296 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 216595001297 Walker A/P-loop; other site 216595001298 ATP binding site [chemical binding]; other site 216595001299 Q-loop/lid; other site 216595001300 ABC transporter signature motif; other site 216595001301 Walker B; other site 216595001302 D-loop; other site 216595001303 H-loop/switch region; other site 216595001305 PS00211 ABC transporters family signature. 216595001306 PS00659 Glycosyl hydrolases family 5 signature. 216595001307 PS00017 ATP/GTP-binding site motif A (P-loop). 216595001308 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 216595001309 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 216595001310 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 216595001313 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 216595001314 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 216595001316 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595001317 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595001318 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595001319 dimerization interface [polypeptide binding]; other site 216595001322 PS00044 Bacterial regulatory proteins, lysR family signature. 216595001323 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 216595001324 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 216595001326 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 216595001327 Sulfatase; Region: Sulfatase; cl10460 216595001329 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595001330 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595001331 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 216595001332 dimerization interface [polypeptide binding]; other site 216595001334 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 216595001336 PS00044 Bacterial regulatory proteins, lysR family signature. 216595001337 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 216595001338 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216595001339 N-terminal plug; other site 216595001340 ligand-binding site [chemical binding]; other site 216595001343 PS01156 TonB-dependent receptor proteins signature 2. 216595001344 putative cyanate transporter; Provisional; Region: cynX; PRK09705 216595001345 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595001347 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595001348 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595001349 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595001350 dimerization interface [polypeptide binding]; other site 216595001352 PS00044 Bacterial regulatory proteins, lysR family signature. 216595001354 Gram-negative bacterial tonB protein; Region: TonB; cl10048 216595001355 1 probable transmembrane helix predicted for PFLU0209 by TMHMM2.0 at aa 52-71 216595001357 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 216595001358 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 216595001359 3 probable transmembrane helices predicted for PFLU0210 by TMHMM2.0 at aa 29-51, 139-161 and 181-203 216595001361 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 216595001363 1 probable transmembrane helix predicted for PFLU0211 by TMHMM2.0 at aa 20-42 216595001364 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595001366 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 216595001367 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595001368 Walker A motif; other site 216595001369 ATP binding site [chemical binding]; other site 216595001370 Walker B motif; other site 216595001372 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 216595001373 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 216595001374 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 216595001376 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 216595001378 Predicted transcriptional regulator [Transcription]; Region: COG3905 216595001381 PS00397 Site-specific recombinases active site. 216595001383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595001384 dimer interface [polypeptide binding]; other site 216595001385 conserved gate region; other site 216595001386 putative PBP binding loops; other site 216595001387 ABC-ATPase subunit interface; other site 216595001389 5 probable transmembrane helices predicted for PFLU0227 by TMHMM2.0 at aa 24-46, 71-93, 137-156, 161-183 and 188-210 216595001390 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595001391 PS00017 ATP/GTP-binding site motif A (P-loop). 216595001392 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216595001393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595001394 dimer interface [polypeptide binding]; other site 216595001395 conserved gate region; other site 216595001396 putative PBP binding loops; other site 216595001397 ABC-ATPase subunit interface; other site 216595001399 4 probable transmembrane helices predicted for PFLU0228 by TMHMM2.0 at aa 20-42, 55-77, 81-103 and 188-207 216595001400 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595001401 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 216595001402 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 216595001403 Walker A/P-loop; other site 216595001404 ATP binding site [chemical binding]; other site 216595001405 Q-loop/lid; other site 216595001406 ABC transporter signature motif; other site 216595001407 Walker B; other site 216595001408 D-loop; other site 216595001409 H-loop/switch region; other site 216595001411 PS00017 ATP/GTP-binding site motif A (P-loop). 216595001412 PS00211 ABC transporters family signature. 216595001413 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 216595001414 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595001415 substrate binding pocket [chemical binding]; other site 216595001416 membrane-bound complex binding site; other site 216595001417 hinge residues; other site 216595001418 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595001420 Predicted ATPase [General function prediction only]; Region: COG4637 216595001421 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595001423 PS00017 ATP/GTP-binding site motif A (P-loop). 216595001424 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 216595001425 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595001427 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 216595001428 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595001430 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 216595001432 11 probable transmembrane helices predicted for PFLU0234 by TMHMM2.0 at aa 15-37, 335-357, 361-380, 392-414, 434-456, 463-485, 521-543, 854-876, 881-900, 907-929 and 985-1007 216595001433 Protein of unknown function (DUF3111); Region: DUF3111; pfam11308 216595001434 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 216595001435 S-adenosylmethionine binding site [chemical binding]; other site 216595001437 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595001438 dimer interface [polypeptide binding]; other site 216595001439 conserved gate region; other site 216595001440 ABC-ATPase subunit interface; other site 216595001442 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595001443 PS00012 Phosphopantetheine attachment site. 216595001444 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 216595001445 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein; Region: ABC_MetN_methionine_transporter; cd03258 216595001446 Walker A/P-loop; other site 216595001447 ATP binding site [chemical binding]; other site 216595001448 Q-loop/lid; other site 216595001449 ABC transporter signature motif; other site 216595001450 Walker B; other site 216595001451 D-loop; other site 216595001452 H-loop/switch region; other site 216595001453 NIL domain; Region: NIL; cl09633 216595001455 PS00211 ABC transporters family signature. 216595001456 PS00017 ATP/GTP-binding site motif A (P-loop). 216595001457 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 216595001459 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 216595001460 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 216595001461 active site 216595001462 non-prolyl cis peptide bond; other site 216595001463 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 216595001464 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 216595001465 Flavin binding site [chemical binding]; other site 216595001468 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 216595001469 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 216595001470 Flavin binding site [chemical binding]; other site 216595001473 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 216595001474 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 216595001475 Walker A/P-loop; other site 216595001476 ATP binding site [chemical binding]; other site 216595001477 Q-loop/lid; other site 216595001478 ABC transporter signature motif; other site 216595001479 Walker B; other site 216595001480 D-loop; other site 216595001481 H-loop/switch region; other site 216595001483 PS00211 ABC transporters family signature. 216595001484 PS00017 ATP/GTP-binding site motif A (P-loop). 216595001485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595001486 dimer interface [polypeptide binding]; other site 216595001487 conserved gate region; other site 216595001488 putative PBP binding loops; other site 216595001489 ABC-ATPase subunit interface; other site 216595001491 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595001492 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 216595001493 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595001494 substrate binding pocket [chemical binding]; other site 216595001495 membrane-bound complex binding site; other site 216595001496 hinge residues; other site 216595001498 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 216595001499 D-cysteine desulfhydrase; Validated; Region: PRK03910 216595001500 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 216595001501 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216595001502 catalytic residue [active] 216595001504 serine O-acetyltransferase; Region: cysE; TIGR01172 216595001505 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354 216595001506 trimer interface [polypeptide binding]; other site 216595001507 active site 216595001508 substrate binding site [chemical binding]; other site 216595001509 CoA binding site [chemical binding]; other site 216595001514 choline transport protein BetT; Provisional; Region: PRK09928 216595001515 BCCT family transporter; Region: BCCT; cl00569 216595001517 12 probable transmembrane helices predicted for PFLU0249 by TMHMM2.0 at aa 55-74, 94-116, 129-151, 181-203, 224-246, 266-288, 301-323, 353-375, 388-407, 448-470, 491-510 and 516-535 216595001518 PS01303 BCCT family of transporters signature. 216595001519 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 216595001520 outer membrane porin, OprD family; Region: OprD; pfam03573 216595001522 PS00047 Histone H4 signature. 216595001523 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 216595001524 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 216595001525 active site 216595001526 catalytic tetrad [active] 216595001528 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 216595001529 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 216595001531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595001532 dimer interface [polypeptide binding]; other site 216595001533 conserved gate region; other site 216595001534 putative PBP binding loops; other site 216595001535 ABC-ATPase subunit interface; other site 216595001537 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595001538 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 216595001539 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 216595001540 Walker A/P-loop; other site 216595001541 ATP binding site [chemical binding]; other site 216595001542 Q-loop/lid; other site 216595001543 ABC transporter signature motif; other site 216595001544 Walker B; other site 216595001545 D-loop; other site 216595001546 H-loop/switch region; other site 216595001548 PS00211 ABC transporters family signature. 216595001549 PS00017 ATP/GTP-binding site motif A (P-loop). 216595001550 taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729 216595001551 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cl15306 216595001552 substrate binding pocket [chemical binding]; other site 216595001553 membrane-bound complex binding site; other site 216595001554 hinge residues; other site 216595001556 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl01099 216595001558 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 216595001559 CoenzymeA binding site [chemical binding]; other site 216595001560 subunit interaction site [polypeptide binding]; other site 216595001561 PHB binding site; other site 216595001563 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 216595001564 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 216595001565 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 216595001566 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin...; Region: S1_Tex; cd05685 216595001567 RNA binding site [nucleotide binding]; other site 216595001569 osmolarity response regulator; Provisional; Region: ompR; PRK09468 216595001570 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595001571 active site 216595001572 phosphorylation site [posttranslational modification] 216595001573 intermolecular recognition site; other site 216595001574 dimerization interface [polypeptide binding]; other site 216595001575 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 216595001576 DNA binding site [nucleotide binding] 216595001579 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 216595001580 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595001581 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595001582 ATP binding site [chemical binding]; other site 216595001583 Mg2+ binding site [ion binding]; other site 216595001584 G-X-G motif; other site 216595001585 2 probable transmembrane helices predicted for PFLU0260 by TMHMM2.0 at aa 15-37 and 145-167 216595001589 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 216595001590 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 216595001592 Protein of unknown function (DUF785); Region: DUF785; cl01682 216595001594 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216595001596 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 216595001597 RNA binding surface [nucleotide binding]; other site 216595001599 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 216595001600 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 216595001601 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 216595001602 dimerization interface [polypeptide binding]; other site 216595001603 domain crossover interface; other site 216595001604 redox-dependent activation switch; other site 216595001606 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 216595001607 active site 216595001608 substrate-binding site [chemical binding]; other site 216595001609 metal-binding site [ion binding] 216595001610 ATP binding site [chemical binding]; other site 216595001612 PS00017 ATP/GTP-binding site motif A (P-loop). 216595001613 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 216595001614 Fic/DOC family; Region: Fic; cl00960 216595001616 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; cl01910 216595001617 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 216595001618 binding surface 216595001619 TPR motif; other site 216595001623 DEAD-like helicases superfamily; Region: DEXDc; smart00487 216595001624 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216595001625 ATP binding site [chemical binding]; other site 216595001626 putative Mg++ binding site [ion binding]; other site 216595001627 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216595001628 nucleotide binding region [chemical binding]; other site 216595001629 ATP-binding site [chemical binding]; other site 216595001631 PS00690 DEAH-box subfamily ATP-dependent helicases signature. 216595001633 PS00190 Cytochrome c family heme-binding site signature. 216595001634 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 216595001635 active site 216595001640 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 216595001641 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 216595001642 putative molybdopterin cofactor binding site [chemical binding]; other site 216595001643 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT)...; Region: MopB_CT_ydeP; cd02787 216595001644 putative molybdopterin cofactor binding site; other site 216595001648 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 216595001650 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595001651 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595001652 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 216595001653 dimerization interface [polypeptide binding]; other site 216595001656 PS00044 Bacterial regulatory proteins, lysR family signature. 216595001657 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 216595001658 BON domain; Region: BON; cl02771 216595001659 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 216595001662 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 216595001663 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 216595001664 motif II; other site 216595001666 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 216595001667 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 216595001668 dimer interface [polypeptide binding]; other site 216595001669 ADP-ribose binding site [chemical binding]; other site 216595001670 active site 216595001671 nudix motif; other site 216595001672 metal binding site [ion binding]; metal-binding site 216595001674 PS00893 mutT domain signature. 216595001675 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 216595001676 active site 216595001678 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 216595001679 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 216595001680 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595001681 active site 216595001682 phosphorylation site [posttranslational modification] 216595001683 intermolecular recognition site; other site 216595001684 dimerization interface [polypeptide binding]; other site 216595001685 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595001686 Walker A motif; other site 216595001687 ATP binding site [chemical binding]; other site 216595001688 Walker B motif; other site 216595001689 arginine finger; other site 216595001690 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 216595001692 PS00688 Sigma-54 interaction domain C-terminal part signature. 216595001694 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 216595001695 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 216595001697 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 216595001698 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595001699 dimer interface [polypeptide binding]; other site 216595001700 phosphorylation site [posttranslational modification] 216595001701 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595001702 ATP binding site [chemical binding]; other site 216595001703 G-X-G motif; other site 216595001706 1 probable transmembrane helix predicted for PFLU0287 by TMHMM2.0 at aa 281-303 216595001707 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 216595001708 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 216595001709 NADP binding site [chemical binding]; other site 216595001710 active site 216595001711 putative substrate binding site [chemical binding]; other site 216595001713 Cupin domain; Region: Cupin_2; cl09118 216595001715 PS00017 ATP/GTP-binding site motif A (P-loop). 216595001716 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 216595001717 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 216595001718 substrate binding site [chemical binding]; other site 216595001719 tetramer interface [polypeptide binding]; other site 216595001721 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 216595001722 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 216595001723 NAD binding site [chemical binding]; other site 216595001724 substrate binding site [chemical binding]; other site 216595001725 homodimer interface [polypeptide binding]; other site 216595001726 active site 216595001728 PS00061 Short-chain dehydrogenases/reductases family signature. 216595001729 hypothetical protein; Provisional; Region: PRK06149 216595001730 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 216595001731 active site 216595001732 ATP binding site [chemical binding]; other site 216595001733 substrate binding site [chemical binding]; other site 216595001734 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 216595001735 inhibitor-cofactor binding pocket; inhibition site 216595001736 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595001737 catalytic residue [active] 216595001740 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 216595001741 agmatine deiminase; Region: agmatine_aguA; TIGR03380 216595001743 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 216595001744 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216595001745 N-terminal plug; other site 216595001746 ligand-binding site [chemical binding]; other site 216595001749 outer membrane porin, OprD family; Region: OprD; pfam03573 216595001751 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595001752 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 216595001753 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 216595001755 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 216595001756 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 216595001757 DXD motif; other site 216595001758 PilZ domain; Region: PilZ; cl01260 216595001759 8 probable transmembrane helices predicted for PFLU0301 by TMHMM2.0 at aa 36-55, 59-76, 83-101, 116-138, 414-436, 440-462, 524-546 and 551-573 216595001762 cellulose synthase regulator protein; Provisional; Region: PRK11114 216595001763 Bacterial cellulose synthase subunit; Region: BcsB; pfam03170 216595001765 1 probable transmembrane helix predicted for PFLU0302 by TMHMM2.0 at aa 724-746 216595001766 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 216595001768 PS00812 Glycosyl hydrolases family 8 signature. 216595001769 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 216595001770 binding surface 216595001771 TPR motif; other site 216595001772 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 216595001773 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 216595001774 binding surface 216595001775 TPR motif; other site 216595001776 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 216595001777 TPR motif; other site 216595001778 binding surface 216595001779 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 216595001785 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 216595001786 active site 216595001787 catalytic triad [active] 216595001788 Alginate O-acetyl transferase AlgF; Region: AlgF; pfam11182 216595001789 MBOAT family; Region: MBOAT; cl00738 216595001790 9 probable transmembrane helices predicted for PFLU0307 by TMHMM2.0 at aa 2-23, 43-65, 78-100, 120-138, 151-170, 239-261, 351-373, 403-425 and 438-460 216595001792 1 probable transmembrane helix predicted for PFLU0308 by TMHMM2.0 at aa 20-41 216595001793 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595001794 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 216595001795 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 216595001796 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 216595001797 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216595001798 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595001799 dimer interface [polypeptide binding]; other site 216595001800 conserved gate region; other site 216595001801 putative PBP binding loops; other site 216595001802 ABC-ATPase subunit interface; other site 216595001804 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595001805 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216595001806 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595001807 dimer interface [polypeptide binding]; other site 216595001808 conserved gate region; other site 216595001809 putative PBP binding loops; other site 216595001810 ABC-ATPase subunit interface; other site 216595001812 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595001813 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216595001814 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595001815 substrate binding pocket [chemical binding]; other site 216595001816 membrane-bound complex binding site; other site 216595001817 hinge residues; other site 216595001819 1 probable transmembrane helix predicted for PFLU0313 by TMHMM2.0 at aa 7-26 216595001820 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 216595001821 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 216595001822 Walker A/P-loop; other site 216595001823 ATP binding site [chemical binding]; other site 216595001824 Q-loop/lid; other site 216595001825 ABC transporter signature motif; other site 216595001826 Walker B; other site 216595001827 D-loop; other site 216595001828 H-loop/switch region; other site 216595001830 PS00211 ABC transporters family signature. 216595001831 PS00017 ATP/GTP-binding site motif A (P-loop). 216595001832 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 216595001834 12 probable transmembrane helices predicted for PFLU0315 by TMHMM2.0 at aa 74-96, 101-120, 141-163, 178-200, 212-234, 254-276, 296-318, 342-364, 390-409, 413-435, 456-478 and 483-505 216595001835 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 216595001836 PS00218 Amino acid permeases signature. 216595001837 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 216595001838 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595001839 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216595001841 PS00120 Lipases, serine active site. 216595001842 Membrane transport protein; Region: Mem_trans; cl09117 216595001843 8 probable transmembrane helices predicted for PFLU0318 by TMHMM2.0 at aa 13-32, 37-56, 68-87, 97-119, 126-148, 163-185, 197-219 and 232-254 216595001844 PS00044 Bacterial regulatory proteins, lysR family signature. 216595001846 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 216595001847 11 probable transmembrane helices predicted for PFLU0319 by TMHMM2.0 at aa 7-26, 85-107, 134-151, 166-188, 201-220, 257-276, 289-308, 313-332, 344-363, 373-395 and 402-424 216595001848 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595001849 Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104 216595001851 adenine DNA glycosylase; Provisional; Region: PRK10880 216595001852 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 216595001853 minor groove reading motif; other site 216595001854 helix-hairpin-helix signature motif; other site 216595001855 substrate binding pocket [chemical binding]; other site 216595001856 active site 216595001857 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 216595001858 DNA binding and oxoG recognition site [nucleotide binding] 216595001861 AsmA family; Region: AsmA; pfam05170 216595001863 PS00017 ATP/GTP-binding site motif A (P-loop). 216595001864 1 probable transmembrane helix predicted for PFLU0324 by TMHMM2.0 at aa 13-35 216595001865 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 216595001866 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595001867 13 probable transmembrane helices predicted for PFLU0325 by TMHMM2.0 at aa 31-53, 91-113, 122-141, 145-167, 187-209, 214-236, 280-302, 329-351, 363-385, 389-411, 423-445, 460-482 and 521-543 216595001869 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 216595001870 putative active site pocket [active] 216595001871 4-fold oligomerization interface [polypeptide binding]; other site 216595001872 metal binding residues [ion binding]; metal-binding site 216595001873 3-fold/trimer interface [polypeptide binding]; other site 216595001875 PS00954 Imidazoleglycerol-phosphate dehydratase signature 1. 216595001876 PS00955 Imidazoleglycerol-phosphate dehydratase signature 2. 216595001877 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 216595001878 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 216595001879 putative active site [active] 216595001880 oxyanion strand; other site 216595001881 catalytic triad [active] 216595001883 PS00442 Glutamine amidotransferases class-I active site. 216595001884 Uncharacterized conserved protein (DUF2164); Region: DUF2164; cl02278 216595001885 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 216595001886 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732 216595001887 catalytic residues [active] 216595001889 Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107 216595001890 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731 216595001891 substrate binding site [chemical binding]; other site 216595001892 glutamase interaction surface [polypeptide binding]; other site 216595001894 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595001895 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216595001896 substrate binding pocket [chemical binding]; other site 216595001897 membrane-bound complex binding site; other site 216595001898 hinge residues; other site 216595001899 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 216595001900 active site 216595001901 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595001902 Divergent polysaccharide deacetylase; Region: Polysacc_deac_2; cl04721 216595001904 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 216595001905 C-terminal peptidase (prc); Region: prc; TIGR00225 216595001906 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 216595001907 protein binding site [polypeptide binding]; other site 216595001908 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 216595001909 Catalytic dyad [active] 216595001912 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 216595001913 Peptidase family M23; Region: Peptidase_M23; pfam01551 216595001915 Sulfatase; Region: Sulfatase; cl10460 216595001916 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 216595001919 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 216595001920 active site residue [active] 216595001921 1 probable transmembrane helix predicted for PFLU0338 by TMHMM2.0 at aa 7-29 216595001923 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 216595001924 GSH binding site [chemical binding]; other site 216595001925 catalytic residues [active] 216595001927 PS00194 Thioredoxin family active site. 216595001928 PS00195 Glutaredoxin active site. 216595001929 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 216595001930 SecA binding site; other site 216595001931 Preprotein binding site; other site 216595001933 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 216595001935 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 216595001936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595001937 active site 216595001938 phosphorylation site [posttranslational modification] 216595001939 intermolecular recognition site; other site 216595001940 dimerization interface [polypeptide binding]; other site 216595001941 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595001942 Walker A motif; other site 216595001943 ATP binding site [chemical binding]; other site 216595001944 Walker B motif; other site 216595001945 arginine finger; other site 216595001946 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 216595001948 PS00688 Sigma-54 interaction domain C-terminal part signature. 216595001950 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 216595001951 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 216595001953 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 216595001954 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 216595001955 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595001956 dimer interface [polypeptide binding]; other site 216595001957 phosphorylation site [posttranslational modification] 216595001958 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595001959 ATP binding site [chemical binding]; other site 216595001960 Mg2+ binding site [ion binding]; other site 216595001961 G-X-G motif; other site 216595001965 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595001966 Cupin domain; Region: Cupin_2; cl09118 216595001968 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595001969 Chorismate mutase type II; Region: CM_2; cl00693 216595001971 glutamine synthetase; Provisional; Region: glnA; PRK09469 216595001972 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 216595001973 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 216595001974 PS00182 Glutamine synthetase class-I adenylation site. 216595001976 PS00181 Glutamine synthetase putative ATP-binding region signature. 216595001978 PS00180 Glutamine synthetase signature 1. 216595001979 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 216595001980 THUMP domain; Region: THUMP; cl12076 216595001981 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 216595001982 Ligand Binding Site [chemical binding]; other site 216595001983 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 216595001986 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 216595001987 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 216595001988 G1 box; other site 216595001989 putative GEF interaction site [polypeptide binding]; other site 216595001990 GTP/Mg2+ binding site [chemical binding]; other site 216595001991 Switch I region; other site 216595001992 G2 box; other site 216595001993 G3 box; other site 216595001994 Switch II region; other site 216595001995 G4 box; other site 216595001996 G5 box; other site 216595001997 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 216595001998 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a...; Region: BipA_TypA_C; cd03710 216595002000 PS00017 ATP/GTP-binding site motif A (P-loop). 216595002001 PS00301 GTP-binding elongation factors signature. 216595002004 Flagellin N-methylase; Region: FliB; cl00497 216595002006 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 216595002007 homodimer interface [polypeptide binding]; other site 216595002008 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 216595002009 active site pocket [active] 216595002011 PS00102 Phosphorylase pyridoxal-phosphate attachment site. 216595002012 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 216595002013 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 216595002014 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 216595002015 32 probable transmembrane helices predicted for PFLU0353 by TMHMM2.0 at aa 156-178, 193-210, 217-236, 246-263, 268-290, 294-313, 318-340, 344-366, 421-443, 447-469, 496-513, 523-542, 563-580, 584-601, 608-630, 640-662, 675-697, 701-718, 725-747, 757-779, 799-821, 826-845, 852-874, 878-897, 910-932, 942-964, 977-994, 1007-1029, 1042-1061, 1081-1103, 1110-1129 and 1134-1156 216595002016 1 probable transmembrane helix predicted for PFLU0354 by TMHMM2.0 at aa 423-445 216595002017 fructose-1,6-bisphosphatase family protein; Region: PLN02628 216595002018 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1,7-...; Region: FBPase; cd00354 216595002019 AMP binding site [chemical binding]; other site 216595002020 metal binding site [ion binding]; metal-binding site 216595002021 active site 216595002023 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 216595002024 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595002025 Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150 216595002026 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595002027 PS00213 Lipocalin signature. 216595002029 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 216595002030 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 216595002031 active site 216595002033 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 216595002034 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595002035 DNA-binding site [nucleotide binding]; DNA binding site 216595002036 UTRA domain; Region: UTRA; cl01230 216595002038 PS00043 Bacterial regulatory proteins, gntR family signature. 216595002040 HutD; Region: HutD; cl01532 216595002042 urocanate hydratase; Provisional; Region: PRK05414 216595002043 urocanate hydratase; Region: hutU; TIGR01228 216595002045 PS01233 Urocanase active site. 216595002046 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 216595002047 Sodium:solute symporter family; Region: SSF; cl00456 216595002049 13 probable transmembrane helices predicted for PFLU0362 by TMHMM2.0 at aa 31-53, 58-80, 95-117, 138-155, 160-182, 195-214, 234-256, 269-291, 296-315, 327-349, 354-376, 397-416 and 426-448 216595002050 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 216595002051 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 216595002053 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595002054 dimer interface [polypeptide binding]; other site 216595002055 conserved gate region; other site 216595002056 putative PBP binding loops; other site 216595002057 ABC-ATPase subunit interface; other site 216595002058 4 probable transmembrane helices predicted for PFLU0364 by TMHMM2.0 at aa 35-57, 70-89, 96-118 and 139-161 216595002060 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 216595002061 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 216595002062 Walker A/P-loop; other site 216595002063 ATP binding site [chemical binding]; other site 216595002064 Q-loop/lid; other site 216595002065 ABC transporter signature motif; other site 216595002066 Walker B; other site 216595002067 D-loop; other site 216595002068 H-loop/switch region; other site 216595002069 PS00017 ATP/GTP-binding site motif A (P-loop). 216595002071 PS00017 ATP/GTP-binding site motif A (P-loop). 216595002072 PS00211 ABC transporters family signature. 216595002073 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 216595002074 tyrosine 2,3-aminomutase; Region: Tyr_2_3_mutase; TIGR03832 216595002075 active sites [active] 216595002076 tetramer interface [polypeptide binding]; other site 216595002078 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595002079 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 216595002080 tyrosine 2,3-aminomutase; Region: Tyr_2_3_mutase; TIGR03832 216595002081 active sites [active] 216595002082 tetramer interface [polypeptide binding]; other site 216595002084 PS00488 Phenylalanine and histidine ammonia-lyases signature. 216595002085 PS00213 Lipocalin signature. 216595002086 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 216595002087 Amino acid permease; Region: AA_permease; pfam00324 216595002089 12 probable transmembrane helices predicted for PFLU0368 by TMHMM2.0 at aa 19-41, 45-64, 88-110, 125-147, 154-176, 201-223, 244-266, 281-303, 333-355, 359-381, 402-424 and 428-450 216595002090 PS00218 Amino acid permeases signature. 216595002091 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 216595002092 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria...; Region: Imidazolone-5PH; cd01296 216595002093 active site 216595002095 N-formylglutamate amidohydrolase; Region: FGase; cl01522 216595002097 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 216595002098 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595002100 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but...; Region: Dtyr_deacylase; cd00563 216595002101 putative active site [active] 216595002102 dimerization interface [polypeptide binding]; other site 216595002103 putative tRNAtyr binding site [nucleotide binding]; other site 216595002105 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl01208 216595002107 Membrane glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: MdoH; COG2943 216595002108 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 216595002109 Ligand binding site [chemical binding]; other site 216595002110 DXD motif; other site 216595002111 6 probable transmembrane helices predicted for PFLU0374 by TMHMM2.0 at aa 143-160, 199-221, 522-544, 572-594, 607-629 and 683-705 216595002113 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216595002114 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595002115 substrate binding pocket [chemical binding]; other site 216595002116 membrane-bound complex binding site; other site 216595002117 hinge residues; other site 216595002118 PS00430 TonB-dependent receptor proteins signature 1. 216595002120 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 216595002121 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595002122 substrate binding pocket [chemical binding]; other site 216595002123 membrane-bound complex binding site; other site 216595002124 hinge residues; other site 216595002125 1 probable transmembrane helix predicted for PFLU0376 by TMHMM2.0 at aa 7-28 216595002127 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 216595002128 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216595002129 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595002130 dimer interface [polypeptide binding]; other site 216595002131 conserved gate region; other site 216595002132 putative PBP binding loops; other site 216595002133 ABC-ATPase subunit interface; other site 216595002134 5 probable transmembrane helices predicted for PFLU0377 by TMHMM2.0 at aa 12-34, 118-140, 161-180, 190-212 and 279-301 216595002136 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595002137 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 216595002138 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 216595002139 Walker A/P-loop; other site 216595002140 ATP binding site [chemical binding]; other site 216595002141 Q-loop/lid; other site 216595002142 ABC transporter signature motif; other site 216595002143 Walker B; other site 216595002144 D-loop; other site 216595002145 H-loop/switch region; other site 216595002147 PS00017 ATP/GTP-binding site motif A (P-loop). 216595002148 PS00211 ABC transporters family signature. 216595002149 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595002150 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595002151 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595002154 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595002155 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595002156 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595002159 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 216595002161 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 216595002163 PS01218 Uncharacterized protein family UPF0032 signature. 216595002164 sec-independent translocase; Provisional; Region: tatB; PRK00404 216595002165 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 216595002167 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 216595002169 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 216595002171 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 216595002173 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 216595002174 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 216595002176 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 216595002177 SCP-2 sterol transfer family; Region: SCP2; cl01225 216595002179 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 216595002180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 216595002181 S-adenosylmethionine binding site [chemical binding]; other site 216595002182 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 216595002184 PS01184 ubiE/COQ5 methyltransferase family signature 2. 216595002185 PS01183 ubiE/COQ5 methyltransferase family signature 1. 216595002186 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865 216595002187 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 216595002189 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 216595002191 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216595002192 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216595002194 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 216595002195 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 216595002198 poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240 216595002199 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595002201 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 216595002202 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 216595002205 PS00017 ATP/GTP-binding site motif A (P-loop). 216595002206 Protein of unknown function (DUF971); Region: DUF971; cl01414 216595002208 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 216595002209 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595002210 Walker A motif; other site 216595002211 ATP binding site [chemical binding]; other site 216595002212 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595002213 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 216595002216 PS00017 ATP/GTP-binding site motif A (P-loop). 216595002217 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 216595002218 active site 216595002219 HslU subunit interaction site [polypeptide binding]; other site 216595002221 Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087 216595002222 Sporulation related domain; Region: SPOR; cl10051 216595002224 1 probable transmembrane helix predicted for PFLU0400 by TMHMM2.0 at aa 24-43 216595002225 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 216595002226 arginine-tRNA ligase; Region: PLN02286 216595002227 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 216595002228 active site 216595002229 HIGH motif; other site 216595002230 KMSK motif region; other site 216595002231 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 216595002232 tRNA binding surface [nucleotide binding]; other site 216595002233 anticodon binding site; other site 216595002236 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 216595002238 primosome assembly protein PriA; Validated; Region: PRK05580 216595002239 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216595002240 ATP binding site [chemical binding]; other site 216595002241 putative Mg++ binding site [ion binding]; other site 216595002242 Hydrogenase expression/synthesis hypA family; Region: HypA; cl00418 216595002243 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595002246 PS00017 ATP/GTP-binding site motif A (P-loop). 216595002247 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 216595002249 PS00190 Cytochrome c family heme-binding site signature. 216595002250 PS01143 Ribosomal protein L31 signature. 216595002251 Staphylococcal nuclease homologues; Region: SNc; smart00318 216595002252 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 216595002253 Catalytic site; other site 216595002255 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 216595002256 Malic enzyme, N-terminal domain; Region: malic; pfam00390 216595002257 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 216595002258 putative NAD(P) binding site [chemical binding]; other site 216595002260 PS00331 Malic enzymes signature. 216595002262 PS00017 ATP/GTP-binding site motif A (P-loop). 216595002264 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 216595002265 Transglycosylase; Region: Transgly; cl07896 216595002266 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 216595002269 1 probable transmembrane helix predicted for PFLU0406 by TMHMM2.0 at aa 7-29 216595002270 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 216595002271 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 216595002273 1 probable transmembrane helix predicted for PFLU0408 by TMHMM2.0 at aa 30-49 216595002274 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595002275 Pilus assembly protein, PilO; Region: PilO; cl01234 216595002276 Pilus assembly protein, PilP; Region: PilP; cl01235 216595002282 PS00875 Bacterial type II secretion system protein D signature. 216595002283 shikimate kinase; Reviewed; Region: aroK; PRK00131 216595002284 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464 216595002285 ADP binding site [chemical binding]; other site 216595002286 magnesium binding site [ion binding]; other site 216595002287 putative shikimate binding site; other site 216595002288 PS00017 ATP/GTP-binding site motif A (P-loop). 216595002290 PS01128 Shikimate kinase signature. 216595002291 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 216595002292 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 216595002293 active site 216595002294 dimer interface [polypeptide binding]; other site 216595002295 metal binding site [ion binding]; metal-binding site 216595002297 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 216595002298 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595002299 Sporulation related domain; Region: SPOR; cl10051 216595002300 PS00017 ATP/GTP-binding site motif A (P-loop). 216595002301 1 probable transmembrane helix predicted for PFLU0413 by TMHMM2.0 at aa 264-281 216595002303 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 216595002304 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The N-...; Region: GltS; cd00713 216595002305 active site 216595002306 dimer interface [polypeptide binding]; other site 216595002307 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 216595002308 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 216595002309 active site 216595002310 FMN binding site [chemical binding]; other site 216595002311 substrate binding site [chemical binding]; other site 216595002312 3Fe-4S cluster binding site [ion binding]; other site 216595002313 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 216595002314 domain interface; other site 216595002316 PS00017 ATP/GTP-binding site motif A (P-loop). 216595002320 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 216595002321 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 216595002322 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595002325 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 216595002326 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This...; Region: URO-D; cd00717 216595002327 substrate binding site [chemical binding]; other site 216595002328 active site 216595002330 PS00906 Uroporphyrinogen decarboxylase signature 1. 216595002331 PS00907 Uroporphyrinogen decarboxylase signature 2. 216595002332 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 216595002333 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595002334 putative substrate translocation pore; other site 216595002336 PS00216 Sugar transport proteins signature 1. 216595002337 PS00216 Sugar transport proteins signature 1. 216595002338 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 216595002339 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595002340 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 216595002341 dimerization interface [polypeptide binding]; other site 216595002342 substrate binding pocket [chemical binding]; other site 216595002344 PS00044 Bacterial regulatory proteins, lysR family signature. 216595002346 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595002347 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 216595002348 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 216595002349 dimer interface [polypeptide binding]; other site 216595002350 active site 216595002353 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595002354 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 216595002355 NAD(P) binding site [chemical binding]; other site 216595002356 active site 216595002358 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 216595002359 putative active site 1 [active] 216595002360 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 216595002361 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 216595002362 dimer interface [polypeptide binding]; other site 216595002363 active site 216595002366 PS00606 Beta-ketoacyl synthases active site. 216595002367 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595002368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 216595002369 S-adenosylmethionine binding site [chemical binding]; other site 216595002370 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 216595002372 PS00017 ATP/GTP-binding site motif A (P-loop). 216595002373 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 216595002374 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595002376 Predicted exporter [General function prediction only]; Region: COG4258 216595002377 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 216595002378 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 216595002379 1 probable transmembrane helix predicted for PFLU0428 by TMHMM2.0 at aa 34-56 216595002380 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 216595002381 active site 216595002383 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 216595002384 tyrosine 2,3-aminomutase; Region: Tyr_2_3_mutase; TIGR03832 216595002385 active sites [active] 216595002386 tetramer interface [polypeptide binding]; other site 216595002388 PS00488 Phenylalanine and histidine ammonia-lyases signature. 216595002389 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595002390 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid...; Region: FabA_FabZ; cd00493 216595002391 active site 2 [active] 216595002392 dimer interface [polypeptide binding]; other site 216595002393 active site 1 [active] 216595002397 Predicted membrane protein [Function unknown]; Region: COG4648 216595002398 Phosphopantetheine attachment site; Region: PP-binding; cl09936 216595002400 Phosphopantetheine attachment site; Region: PP-binding; cl09936 216595002402 PS00012 Phosphopantetheine attachment site. 216595002403 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 216595002404 putative acyl-acceptor binding pocket; other site 216595002406 1 probable transmembrane helix predicted for PFLU0437 by TMHMM2.0 at aa 20-42 216595002407 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 216595002408 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 216595002409 P loop; other site 216595002410 Nucleotide binding site [chemical binding]; other site 216595002411 DTAP/Switch II; other site 216595002412 Switch I; other site 216595002414 thioredoxin 2; Provisional; Region: PRK10996 216595002415 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 216595002416 catalytic residues [active] 216595002418 PS00194 Thioredoxin family active site. 216595002419 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 216595002420 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 216595002421 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 216595002422 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 216595002424 hypothetical protein; Provisional; Region: PRK11281 216595002425 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 216595002426 Mechanosensitive ion channel; Region: MS_channel; pfam00924 216595002428 PS01246 Uncharacterized protein family UPF0003 signature. 216595002429 PS00012 Phosphopantetheine attachment site. 216595002430 PS00017 ATP/GTP-binding site motif A (P-loop). 216595002431 potassium/proton antiporter; Reviewed; Region: PRK05326 216595002432 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 216595002433 Transporter associated domain; Region: CorC_HlyC; cl08393 216595002437 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 216595002438 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595002439 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595002440 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595002443 Cell division protein ZapA; Region: ZapA; cl01146 216595002445 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 216595002446 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 216595002447 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216595002448 active site 216595002449 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 216595002450 PS00216 Sugar transport proteins signature 1. 216595002453 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 216595002454 Predicted transcriptional regulator [Transcription]; Region: COG3905 216595002455 Proline dehydrogenase; Region: Pro_dh; cl03282 216595002456 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 216595002457 Glutamate binding site [chemical binding]; other site 216595002458 NAD binding site [chemical binding]; other site 216595002459 catalytic residues [active] 216595002461 PS00070 Aldehyde dehydrogenases cysteine active site. 216595002463 Sodium:solute symporter family; Region: SSF; cl00456 216595002464 12 probable transmembrane helices predicted for PFLU0452 by TMHMM2.0 at aa 7-26, 66-88, 127-149, 164-183, 196-218, 233-255, 276-298, 326-348, 369-391, 401-422, 429-446 and 450-469 216595002466 PS00456 Sodium:solute symporter family signature 1. 216595002467 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 216595002468 Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432 216595002470 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 216595002471 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 216595002472 homodimer interface [polypeptide binding]; other site 216595002473 substrate-cofactor binding pocket; other site 216595002474 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595002475 catalytic residue [active] 216595002477 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 216595002479 PS00092 N-6 Adenine-specific DNA methylases signature. 216595002480 PS00092 N-6 Adenine-specific DNA methylases signature. 216595002482 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 216595002484 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 216595002485 GAF domain; Region: GAF; cl00853 216595002486 PAS domain S-box; Region: sensory_box; TIGR00229 216595002487 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216595002488 putative active site [active] 216595002489 heme pocket [chemical binding]; other site 216595002490 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216595002491 metal binding site [ion binding]; metal-binding site 216595002492 active site 216595002493 I-site; other site 216595002494 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216595002499 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 216595002500 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 216595002501 E3 interaction surface; other site 216595002502 lipoyl attachment site [posttranslational modification]; other site 216595002503 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 216595002504 E3 interaction surface; other site 216595002505 lipoyl attachment site [posttranslational modification]; other site 216595002506 e3 binding domain; Region: E3_binding; pfam02817 216595002507 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 216595002511 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 216595002513 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 216595002514 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 216595002515 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 216595002516 dimer interface [polypeptide binding]; other site 216595002517 TPP-binding site [chemical binding]; other site 216595002520 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 216595002521 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 216595002522 metal binding triad; other site 216595002523 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 216595002524 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 216595002525 metal binding triad; other site 216595002528 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 216595002529 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 216595002530 putative active site [active] 216595002532 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 216595002533 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 216595002534 putative active site [active] 216595002536 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216595002537 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 216595002538 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 216595002540 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 216595002542 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 216595002544 PS00108 Serine/Threonine protein kinases active-site signature. 216595002545 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 216595002547 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 216595002548 active site 216595002549 ATP binding site [chemical binding]; other site 216595002550 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 216595002552 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 216595002553 putative ligand binding site [chemical binding]; other site 216595002554 PS00017 ATP/GTP-binding site motif A (P-loop). 216595002555 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216595002556 TM-ABC transporter signature motif; other site 216595002557 9 probable transmembrane helices predicted for PFLU0471 by TMHMM2.0 at aa 10-32, 39-61, 87-109, 116-135, 150-172, 200-222, 227-249, 256-278 and 282-301 216595002559 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595002560 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 216595002561 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216595002562 N-terminal plug; other site 216595002563 ligand-binding site [chemical binding]; other site 216595002565 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 216595002567 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 216595002568 2 probable transmembrane helices predicted for PFLU0474 by TMHMM2.0 at aa 13-35 and 85-107 216595002569 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 216595002570 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 216595002572 Mig-14; Region: Mig-14; pfam07395 216595002574 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 216595002575 1 probable transmembrane helix predicted for PFLU0477 by TMHMM2.0 at aa 26-48 216595002577 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 216595002578 putative ADP-binding pocket [chemical binding]; other site 216595002580 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 216595002581 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 216595002582 active site 216595002584 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 216595002585 O-Antigen ligase; Region: Wzy_C; cl04850 216595002586 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 216595002587 active site 216595002588 substrate binding site [chemical binding]; other site 216595002589 ATP binding site [chemical binding]; other site 216595002591 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 216595002592 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 216595002593 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 216595002594 Walker A/P-loop; other site 216595002595 ATP binding site [chemical binding]; other site 216595002596 Q-loop/lid; other site 216595002597 ABC transporter signature motif; other site 216595002598 Walker B; other site 216595002599 D-loop; other site 216595002600 H-loop/switch region; other site 216595002601 5 probable transmembrane helices predicted for PFLU0481 by TMHMM2.0 at aa 39-61, 94-116, 172-189, 194-213 and 277-299 216595002604 PS00017 ATP/GTP-binding site motif A (P-loop). 216595002605 PS00211 ABC transporters family signature. 216595002606 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 216595002607 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 216595002608 putative ribose interaction site [chemical binding]; other site 216595002609 putative ADP binding site [chemical binding]; other site 216595002610 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 216595002611 active site 216595002612 nucleotide binding site [chemical binding]; other site 216595002613 HIGH motif; other site 216595002614 KMSKS motif; other site 216595002616 PS00583 pfkB family of carbohydrate kinases signature 1. 216595002618 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595002619 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 216595002620 NAD(P) binding site [chemical binding]; other site 216595002621 active site 216595002623 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 216595002624 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 216595002625 active site 216595002626 catalytic tetrad [active] 216595002628 PS00017 ATP/GTP-binding site motif A (P-loop). 216595002629 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 216595002630 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595002631 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 216595002633 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 216595002635 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595002636 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595002637 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 216595002638 dimerization interface [polypeptide binding]; other site 216595002641 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 216595002642 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 216595002643 Glycosyl transferases group 1; Region: Glycos_transf_1; cl12012 216595002644 1 probable transmembrane helix predicted for PFLU0490 by TMHMM2.0 at aa 20-38 216595002647 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 216595002648 Outer membrane efflux protein; Region: OEP; pfam02321 216595002649 Outer membrane efflux protein; Region: OEP; pfam02321 216595002652 ThiC family; Region: ThiC; cl08031 216595002654 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595002655 Sodium:solute symporter family; Region: SSF; cl00456 216595002657 11 probable transmembrane helices predicted for PFLU0493 by TMHMM2.0 at aa 20-39, 60-82, 104-126, 133-150, 165-187, 199-221, 231-253, 280-299, 304-321, 334-356 and 362-384 216595002658 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 216595002659 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595002660 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 216595002661 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 216595002662 dimer interface [polypeptide binding]; other site 216595002663 ADP-ribose binding site [chemical binding]; other site 216595002664 active site 216595002665 nudix motif; other site 216595002666 metal binding site [ion binding]; metal-binding site 216595002668 Protein of unknown function (DUF1249); Region: DUF1249; cl01223 216595002670 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 216595002671 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 216595002672 active site 216595002673 metal binding site [ion binding]; metal-binding site 216595002674 hexamer interface [polypeptide binding]; other site 216595002677 Uncharacterised protein family (UPF0227); Region: UPF0227; cl14886 216595002679 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 216595002680 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595002681 ATP binding site [chemical binding]; other site 216595002682 Mg2+ binding site [ion binding]; other site 216595002683 G-X-G motif; other site 216595002684 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 216595002685 anchoring element; other site 216595002686 dimer interface [polypeptide binding]; other site 216595002687 ATP binding site [chemical binding]; other site 216595002688 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 216595002689 active site 216595002690 metal binding site [ion binding]; metal-binding site 216595002691 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 216595002694 PS00177 DNA topoisomerase II signature. 216595002696 SdiA-regulated; Region: SdiA-regulated; cl06158 216595002697 putative active site [active] 216595002698 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 216595002699 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 216595002700 CAP-like domain; other site 216595002701 Active site [active] 216595002702 primary dimer interface [polypeptide binding]; other site 216595002706 Protein of unknown function (DUF330); Region: DUF330; cl01135 216595002708 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595002709 Bacterial virulence factor haemolysin; Region: SMP_2; cl11479 216595002711 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 216595002712 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 216595002713 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 216595002714 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 216595002715 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 216595002716 motif II; other site 216595002717 PS00228 Tubulin-beta mRNA autoregulation signal. 216595002720 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 216595002722 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but...; Region: TST_Repeat_1; cd01448 216595002723 active site residue [active] 216595002724 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 216595002725 active site residue [active] 216595002727 PS00683 Rhodanese C-terminal signature. 216595002729 PS00380 Rhodanese signature 1. 216595002730 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 216595002731 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 216595002732 5 probable transmembrane helices predicted for PFLU0508 by TMHMM2.0 at aa 4-21, 26-48, 63-85, 172-191 and 201-223 216595002733 PS01307 Flagellar motor protein motA family signature. 216595002734 flagellar motor protein MotB; Validated; Region: motB; PRK09041 216595002735 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216595002736 ligand binding site [chemical binding]; other site 216595002737 1 probable transmembrane helix predicted for PFLU0509 by TMHMM2.0 at aa 21-43 216595002739 PemK-like protein; Region: PemK; cl00995 216595002740 GTPase RsgA; Reviewed; Region: PRK12288 216595002741 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854 216595002742 GTPase/OB domain interface [polypeptide binding]; other site 216595002743 GTPase/Zn-binding domain interface [polypeptide binding]; other site 216595002744 GTP/Mg2+ binding site [chemical binding]; other site 216595002745 G4 box; other site 216595002746 G5 box; other site 216595002747 G1 box; other site 216595002748 Switch I region; other site 216595002749 G2 box; other site 216595002750 G3 box; other site 216595002751 Switch II region; other site 216595002753 PS00017 ATP/GTP-binding site motif A (P-loop). 216595002754 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 216595002755 putative active site [active] 216595002756 putative substrate binding site [chemical binding]; other site 216595002757 catalytic site [active] 216595002758 dimer interface [polypeptide binding]; other site 216595002760 Predicted membrane protein [Function unknown]; Region: COG2860 216595002761 UPF0126 domain; Region: UPF0126; pfam03458 216595002762 UPF0126 domain; Region: UPF0126; pfam03458 216595002764 7 probable transmembrane helices predicted for PFLU0513 by TMHMM2.0 at aa 4-21, 28-50, 63-80, 87-109, 113-135, 148-167 and 171-188 216595002766 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 216595002767 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 216595002769 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216595002771 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 216595002772 putative substrate binding site [chemical binding]; other site 216595002773 putative ATP binding site [chemical binding]; other site 216595002775 PS00017 ATP/GTP-binding site motif A (P-loop). 216595002776 PS01050 Uncharacterized protein family UPF0031 signature 2. 216595002777 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 216595002779 PS00017 ATP/GTP-binding site motif A (P-loop). 216595002780 Localisation of periplasmic protein complexes; Region: AMIN; pfam11741 216595002781 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 216595002782 active site 216595002783 metal binding site [ion binding]; metal-binding site 216595002784 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 216595002785 putative peptidoglycan binding site; other site 216595002786 1 probable transmembrane helix predicted for PFLU0517 by TMHMM2.0 at aa 7-29 216595002789 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 216595002790 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595002791 ATP binding site [chemical binding]; other site 216595002792 Mg2+ binding site [ion binding]; other site 216595002793 G-X-G motif; other site 216595002794 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 216595002795 ATP binding site [chemical binding]; other site 216595002796 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 216595002798 PS00058 DNA mismatch repair proteins mutL / hexB / PMS1 signature. 216595002801 IPP transferase; Region: IPPT; cl00403 216595002802 PS00017 ATP/GTP-binding site motif A (P-loop). 216595002804 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 216595002805 Sm1 motif; other site 216595002806 D3 - B interaction site; other site 216595002807 D1 - D2 interaction site; other site 216595002808 Hfq - Hfq interaction site; other site 216595002809 RNA binding pocket [nucleotide binding]; other site 216595002810 Sm2 motif; other site 216595002812 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 216595002813 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 216595002814 G1 box; other site 216595002815 GTP/Mg2+ binding site [chemical binding]; other site 216595002816 Switch I region; other site 216595002817 G2 box; other site 216595002818 G3 box; other site 216595002819 Switch II region; other site 216595002820 G4 box; other site 216595002821 G5 box; other site 216595002823 PS00017 ATP/GTP-binding site motif A (P-loop). 216595002824 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 216595002825 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 216595002826 HflK protein; Region: hflK; TIGR01933 216595002827 1 probable transmembrane helix predicted for PFLU0522 by TMHMM2.0 at aa 93-115 216595002829 FtsH protease regulator HflC; Provisional; Region: PRK11029 216595002830 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 216595002831 1 probable transmembrane helix predicted for PFLU0523 by TMHMM2.0 at aa 7-29 216595002833 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 216595002834 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 216595002835 dimer interface [polypeptide binding]; other site 216595002836 motif 1; other site 216595002837 active site 216595002838 motif 2; other site 216595002839 motif 3; other site 216595002841 adenylosuccinate synthetase; Provisional; Region: PRK01117 216595002842 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108 216595002843 GDP-binding site [chemical binding]; other site 216595002844 ACT binding site; other site 216595002845 IMP binding site; other site 216595002847 PS01266 Adenylosuccinate synthetase GTP-binding site. 216595002848 PS00513 Adenylosuccinate synthetase active site. 216595002849 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595002850 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595002851 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595002852 2 probable transmembrane helices predicted for PFLU0526 by TMHMM2.0 at aa 44-66 and 322-344 216595002855 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 216595002856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595002857 dimer interface [polypeptide binding]; other site 216595002858 conserved gate region; other site 216595002859 putative PBP binding loops; other site 216595002860 ABC-ATPase subunit interface; other site 216595002861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 216595002863 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595002865 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595002866 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595002868 1 probable transmembrane helix predicted for PFLU0528 by TMHMM2.0 at aa 12-31 216595002869 ribonuclease R; Region: RNase_R; TIGR02063 216595002870 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 216595002871 RNB domain; Region: RNB; pfam00773 216595002872 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an...; Region: S1_RNase_R; cd04471 216595002873 RNA binding site [nucleotide binding]; other site 216595002877 PS01175 Ribonuclease II family signature. 216595002879 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 216595002880 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 216595002881 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 216595002884 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 216595002886 PS01048 Ribosomal protein S6 signature. 216595002887 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 216595002889 PS00057 Ribosomal protein S18 signature. 216595002890 7 probable transmembrane helices predicted for PFLU0535 by TMHMM2.0 at aa 15-37, 49-66, 90-109, 151-173, 193-215, 220-242 and 252-274 216595002891 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 216595002892 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 216595002894 PS00651 Ribosomal protein L9 signature. 216595002896 replicative DNA helicase; Provisional; Region: PRK05748 216595002897 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 216595002898 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 216595002899 Walker A motif; other site 216595002900 ATP binding site [chemical binding]; other site 216595002901 Walker B motif; other site 216595002902 DNA binding loops [nucleotide binding] 216595002905 PS00017 ATP/GTP-binding site motif A (P-loop). 216595002906 hypothetical protein; Provisional; Region: PRK01254 216595002907 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 216595002908 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 216595002911 PS01278 Uncharacterized protein family UPF0004 signature. 216595002912 4 probable transmembrane helices predicted for PFLU0540 by TMHMM2.0 at aa 13-35, 50-72, 79-98 and 103-122 216595002913 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 216595002914 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 216595002915 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 216595002916 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 216595002917 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 216595002920 Uncharacterized conserved protein [Function unknown]; Region: COG2308 216595002921 Domain of unknown function (DUF404); Region: DUF404; pfam04169 216595002922 Domain of unknown function (DUF407); Region: DUF407; pfam04174 216595002923 Bacterial domain of unknown function (DUF403); Region: DUF403; cl00980 216595002927 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 216595002928 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 216595002931 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 216595002933 PS00196 Type-1 copper (blue) proteins signature. 216595002934 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 216595002935 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 216595002936 homodimer interface [polypeptide binding]; other site 216595002937 NAD binding pocket [chemical binding]; other site 216595002938 ATP binding pocket [chemical binding]; other site 216595002939 Mg binding site [ion binding]; other site 216595002940 active-site loop [active] 216595002942 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 216595002943 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: PncB_like; cd01401 216595002944 active site 216595002946 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 216595002947 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595002948 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595002949 dimerization interface [polypeptide binding]; other site 216595002952 PS00044 Bacterial regulatory proteins, lysR family signature. 216595002953 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216595002954 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 216595002955 tetrameric interface [polypeptide binding]; other site 216595002956 NAD binding site [chemical binding]; other site 216595002957 catalytic residues [active] 216595002959 PS00687 Aldehyde dehydrogenases glutamic acid active site. 216595002960 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 216595002961 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 216595002963 Signal peptide predicted for PFLU0551 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.994 between residues 38 and 39 216595002964 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 216595002965 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 216595002966 dimerization interface [polypeptide binding]; other site 216595002967 ligand binding site [chemical binding]; other site 216595002968 1 probable transmembrane helix predicted for PFLU0551 by TMHMM2.0 at aa 21-38 216595002970 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 216595002971 TM-ABC transporter signature motif; other site 216595002973 8 probable transmembrane helices predicted for PFLU0553 by TMHMM2.0 at aa 15-37, 44-61, 66-88, 149-171, 199-221, 228-250, 254-271 and 278-295 216595002974 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 216595002975 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 216595002976 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 216595002977 TM-ABC transporter signature motif; other site 216595002978 11 probable transmembrane helices predicted for PFLU0554 by TMHMM2.0 at aa 13-35, 45-65, 95-113, 117-139, 146-165, 170-192, 199-221, 265-282, 312-334, 354-376 and 389-406 216595002980 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 216595002981 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 216595002982 Walker A/P-loop; other site 216595002983 ATP binding site [chemical binding]; other site 216595002984 Q-loop/lid; other site 216595002985 ABC transporter signature motif; other site 216595002986 Walker B; other site 216595002987 D-loop; other site 216595002988 H-loop/switch region; other site 216595002990 PS00017 ATP/GTP-binding site motif A (P-loop). 216595002991 PS00211 ABC transporters family signature. 216595002992 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 216595002993 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 216595002994 Walker A/P-loop; other site 216595002995 ATP binding site [chemical binding]; other site 216595002996 Q-loop/lid; other site 216595002997 ABC transporter signature motif; other site 216595002998 Walker B; other site 216595002999 D-loop; other site 216595003000 H-loop/switch region; other site 216595003002 PS00017 ATP/GTP-binding site motif A (P-loop). 216595003003 PS00211 ABC transporters family signature. 216595003004 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 216595003005 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 216595003006 putative NAD(P) binding site [chemical binding]; other site 216595003007 homotetramer interface [polypeptide binding]; other site 216595003008 homodimer interface [polypeptide binding]; other site 216595003009 active site 216595003011 PS00061 Short-chain dehydrogenases/reductases family signature. 216595003012 Cation efflux family; Region: Cation_efflux; cl00316 216595003014 6 probable transmembrane helices predicted for PFLU0558 by TMHMM2.0 at aa 31-53, 57-76, 97-119, 129-148, 165-187 and 197-219 216595003015 N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942 216595003016 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 216595003017 putative active cleft [active] 216595003019 HupE / UreJ protein; Region: HupE_UreJ; cl01011 216595003021 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 216595003023 PS00017 ATP/GTP-binding site motif A (P-loop). 216595003024 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 216595003025 UreF; Region: UreF; pfam01730 216595003026 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595003028 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 216595003029 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The C-...; Region: UreE; cd00571 216595003030 dimer interface [polypeptide binding]; other site 216595003031 catalytic residues [active] 216595003034 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 216595003035 NlpC/P60 family; Region: NLPC_P60; cl11438 216595003037 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 216595003038 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216595003040 3 probable transmembrane helices predicted for PFLU0566 by TMHMM2.0 at aa 56-78, 85-107 and 127-149 216595003041 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 216595003043 1 probable transmembrane helix predicted for PFLU0567 by TMHMM2.0 at aa 7-29 216595003044 Ferritin-like domain; Region: Ferritin; pfam00210 216595003045 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 216595003046 dinuclear metal binding motif [ion binding]; other site 216595003048 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 216595003050 PS00120 Lipases, serine active site. 216595003051 PS00215 Mitochondrial energy transfer proteins signature. 216595003052 EamA-like transporter family; Region: EamA; cl01037 216595003055 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216595003058 psiF repeat; Region: PsiF_repeat; pfam07769 216595003059 psiF repeat; Region: PsiF_repeat; pfam07769 216595003062 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 216595003063 7 probable transmembrane helices predicted for PFLU0573 by TMHMM2.0 at aa 10-41, 62-84, 149-168, 206-228, 233-250, 255-277 and 305-327 216595003064 putative chaperone; Provisional; Region: PRK11678 216595003066 PS00329 Heat shock hsp70 proteins family signature 2. 216595003067 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 216595003068 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 216595003069 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 216595003072 E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387 216595003075 urease subunit alpha; Reviewed; Region: ureC; PRK13207 216595003076 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 216595003077 subunit interactions [polypeptide binding]; other site 216595003078 active site 216595003079 flap region; other site 216595003081 PS00145 Urease active site. 216595003082 PS01120 Urease nickel ligands signature. 216595003084 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_beta; cd00407 216595003085 gamma-beta subunit interface [polypeptide binding]; other site 216595003086 alpha-beta subunit interface [polypeptide binding]; other site 216595003088 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216595003089 Coenzyme A binding pocket [chemical binding]; other site 216595003091 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 216595003092 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 216595003094 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 216595003095 alpha-gamma subunit interface [polypeptide binding]; other site 216595003096 beta-gamma subunit interface [polypeptide binding]; other site 216595003098 UreD urease accessory protein; Region: UreD; cl00530 216595003100 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 216595003101 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 216595003102 Walker A/P-loop; other site 216595003103 ATP binding site [chemical binding]; other site 216595003104 Q-loop/lid; other site 216595003105 ABC transporter signature motif; other site 216595003106 Walker B; other site 216595003107 D-loop; other site 216595003108 H-loop/switch region; other site 216595003110 PS00017 ATP/GTP-binding site motif A (P-loop). 216595003111 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 216595003112 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 216595003113 Walker A/P-loop; other site 216595003114 ATP binding site [chemical binding]; other site 216595003115 Q-loop/lid; other site 216595003116 ABC transporter signature motif; other site 216595003117 Walker B; other site 216595003118 D-loop; other site 216595003119 H-loop/switch region; other site 216595003121 PS00017 ATP/GTP-binding site motif A (P-loop). 216595003122 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 216595003123 TM-ABC transporter signature motif; other site 216595003125 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 216595003126 TM-ABC transporter signature motif; other site 216595003128 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 216595003129 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 216595003130 putative ligand binding site [chemical binding]; other site 216595003131 PS00014 Endoplasmic reticulum targeting sequence. 216595003132 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 216595003133 ABC-ATPase subunit interface; other site 216595003134 dimer interface [polypeptide binding]; other site 216595003135 putative PBP binding regions; other site 216595003137 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595003138 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 216595003139 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 216595003140 putative ligand binding residues [chemical binding]; other site 216595003142 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 216595003143 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 216595003144 Walker A/P-loop; other site 216595003145 ATP binding site [chemical binding]; other site 216595003146 Q-loop/lid; other site 216595003147 ABC transporter signature motif; other site 216595003148 Walker B; other site 216595003149 D-loop; other site 216595003150 H-loop/switch region; other site 216595003152 PS00211 ABC transporters family signature. 216595003153 PS00017 ATP/GTP-binding site motif A (P-loop). 216595003154 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 216595003155 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216595003156 N-terminal plug; other site 216595003157 ligand-binding site [chemical binding]; other site 216595003159 PS00815 Alpha-isopropylmalate and homocitrate synthases signature 1. 216595003161 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216595003162 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 216595003163 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 216595003169 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216595003170 N-terminal plug; other site 216595003171 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 216595003172 ligand-binding site [chemical binding]; other site 216595003175 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 216595003176 1 probable transmembrane helix predicted for PFLU0596 by TMHMM2.0 at aa 17-39 216595003177 Protein of unknown function (DUF461); Region: DUF461; cl01071 216595003179 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 216595003180 1 probable transmembrane helix predicted for PFLU0598 by TMHMM2.0 at aa 7-29 216595003181 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 216595003182 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 216595003184 PS00304 Small, acid-soluble spore proteins, alpha/beta type, signature 1. 216595003185 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 216595003186 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 216595003187 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 216595003189 precorrin-3B synthase; Region: CobG; TIGR02435 216595003190 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 216595003193 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 216595003195 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 216595003196 Precorrin-8X methylmutase; Region: CbiC; pfam02570 216595003198 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 216595003200 PS00840 Uroporphyrin-III C-methyltransferase signature 2. 216595003201 PS00215 Mitochondrial energy transfer proteins signature. 216595003202 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 216595003203 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 216595003204 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 216595003205 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 216595003207 PS00300 SRP54-type proteins GTP-binding domain signature. 216595003209 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 216595003210 tetramer interface [polypeptide binding]; other site 216595003211 MarC family integral membrane protein; Region: MarC; cl00919 216595003213 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 216595003214 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 216595003215 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595003216 dimer interface [polypeptide binding]; other site 216595003217 phosphorylation site [posttranslational modification] 216595003218 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595003219 ATP binding site [chemical binding]; other site 216595003220 Mg2+ binding site [ion binding]; other site 216595003221 G-X-G motif; other site 216595003222 Response regulator receiver domain; Region: Response_reg; pfam00072 216595003223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595003224 active site 216595003225 phosphorylation site [posttranslational modification] 216595003226 intermolecular recognition site; other site 216595003227 dimerization interface [polypeptide binding]; other site 216595003228 Response regulator receiver domain; Region: Response_reg; pfam00072 216595003229 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595003230 active site 216595003231 phosphorylation site [posttranslational modification] 216595003232 intermolecular recognition site; other site 216595003233 dimerization interface [polypeptide binding]; other site 216595003240 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 216595003241 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 216595003242 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 216595003243 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 216595003245 PS00184 Phosphoribosylglycinamide synthetase signature. 216595003248 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 216595003249 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421 216595003250 purine monophosphate binding site [chemical binding]; other site 216595003251 dimer interface [polypeptide binding]; other site 216595003252 putative catalytic residues [active] 216595003253 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 216595003254 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 216595003257 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 216595003259 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 216595003260 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 216595003261 FMN binding site [chemical binding]; other site 216595003262 active site 216595003263 catalytic residues [active] 216595003264 substrate binding site [chemical binding]; other site 216595003266 PS01136 Uncharacterized protein family UPF0034 signature. 216595003267 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 216595003268 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 216595003269 1 probable transmembrane helix predicted for PFLU0615 by TMHMM2.0 at aa 263-285 216595003270 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 216595003271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 216595003273 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 216595003274 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 216595003275 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 216595003276 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 216595003279 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 216595003280 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 216595003282 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 216595003283 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 216595003284 carboxyltransferase (CT) interaction site; other site 216595003285 biotinylation site [posttranslational modification]; other site 216595003287 PS00188 Biotin-requiring enzymes attachment site. 216595003288 PS00017 ATP/GTP-binding site motif A (P-loop). 216595003289 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 216595003290 active site 216595003291 trimer interface [polypeptide binding]; other site 216595003292 dimer interface [polypeptide binding]; other site 216595003294 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595003295 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595003297 1 probable transmembrane helix predicted for PFLU0620 by TMHMM2.0 at aa 5-27 216595003298 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 216595003299 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595003300 active site 216595003301 phosphorylation site [posttranslational modification] 216595003302 intermolecular recognition site; other site 216595003303 dimerization interface [polypeptide binding]; other site 216595003304 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216595003305 metal binding site [ion binding]; metal-binding site 216595003306 active site 216595003307 I-site; other site 216595003310 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; cl11978 216595003311 1 probable transmembrane helix predicted for PFLU0623 by TMHMM2.0 at aa 29-51 216595003312 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 216595003313 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 216595003314 nudix motif; other site 216595003316 PS00893 mutT domain signature. 216595003317 translation initiation factor Sui1; Validated; Region: PRK06824 216595003318 The SUI1/eIF1 (eukaryotic initiation factor 1) fold is found in eukaryotes, archaea, and some bacteria and is thought to play an important role in accurate initiator codon recognition during translation initiation. This fold, which includes two...; Region: SUI1_eIF1; cd00474 216595003319 Predicted RNA interaction site [nucleotide binding]; other site 216595003320 putative binding site; other site 216595003321 Mutations affecting start-site selection; other site 216595003323 PS01118 Translation initiation factor SUI1 signature. 216595003324 arginine decarboxylase; Provisional; Region: PRK05354 216595003325 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 216595003326 dimer interface [polypeptide binding]; other site 216595003327 active site 216595003328 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 216595003329 catalytic residues [active] 216595003330 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 216595003332 PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2. 216595003334 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595003335 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 216595003336 substrate binding pocket [chemical binding]; other site 216595003338 PS00120 Lipases, serine active site. 216595003339 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 216595003340 MatE; Region: MatE; cl10513 216595003343 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 216595003344 MG2 domain; Region: A2M_N; pfam01835 216595003345 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 216595003346 Alpha-2-macroglobulin family; Region: A2M; pfam00207 216595003347 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 216595003348 surface patch; other site 216595003349 thioester region; other site 216595003350 specificity defining residues; other site 216595003351 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595003354 penicillin-binding protein 1C; Provisional; Region: PRK11240 216595003355 Transglycosylase; Region: Transgly; cl07896 216595003356 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 216595003357 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 216595003358 1 probable transmembrane helix predicted for PFLU0631 by TMHMM2.0 at aa 5-24 216595003362 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 216595003363 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 216595003364 S-adenosylmethionine binding site [chemical binding]; other site 216595003366 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595003367 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595003368 Predicted membrane protein [Function unknown]; Region: COG4655 216595003369 Predicted membrane protein (DUF2134); Region: DUF2134; pfam09977 216595003370 1 probable transmembrane helix predicted for PFLU0636 by TMHMM2.0 at aa 13-32 216595003371 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595003372 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216595003373 PAS fold; Region: PAS_3; pfam08447 216595003374 putative active site [active] 216595003375 heme pocket [chemical binding]; other site 216595003376 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 216595003377 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595003378 dimer interface [polypeptide binding]; other site 216595003379 phosphorylation site [posttranslational modification] 216595003380 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595003381 ATP binding site [chemical binding]; other site 216595003382 Mg2+ binding site [ion binding]; other site 216595003383 G-X-G motif; other site 216595003388 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 216595003389 TadE-like protein; Region: TadE; pfam07811 216595003391 1 probable transmembrane helix predicted for PFLU0638 by TMHMM2.0 at aa 13-35 216595003393 4 probable transmembrane helices predicted for PFLU0639 by TMHMM2.0 at aa 24-46, 56-78, 85-107 and 131-148 216595003394 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216595003395 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595003396 active site 216595003397 phosphorylation site [posttranslational modification] 216595003398 intermolecular recognition site; other site 216595003399 dimerization interface [polypeptide binding]; other site 216595003400 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 216595003401 DNA binding residues [nucleotide binding] 216595003402 dimerization interface [polypeptide binding]; other site 216595003405 Protein of unknown function (DUF3613); Region: DUF3613; pfam12266 216595003406 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 216595003407 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 216595003408 binding surface 216595003409 TPR motif; other site 216595003411 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595003413 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 216595003415 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 216595003416 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial...; Region: VirB11-like_ATPase; cd01130 216595003417 ATP binding site [chemical binding]; other site 216595003418 Walker A motif; other site 216595003419 hexamer interface [polypeptide binding]; other site 216595003420 Walker B motif; other site 216595003422 PS00017 ATP/GTP-binding site motif A (P-loop). 216595003423 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 216595003424 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 216595003425 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 216595003427 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595003428 1 probable transmembrane helix predicted for PFLU0647 by TMHMM2.0 at aa 7-29 216595003429 SAF domain; Region: SAF; cl00555 216595003431 1 probable transmembrane helix predicted for PFLU0648 by TMHMM2.0 at aa 5-27 216595003433 1 probable transmembrane helix predicted for PFLU0649 by TMHMM2.0 at aa 25-47 216595003434 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595003435 active site 216595003436 phosphorylation site [posttranslational modification] 216595003437 intermolecular recognition site; other site 216595003438 dimerization interface [polypeptide binding]; other site 216595003440 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 216595003441 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 216595003442 PS00213 Lipocalin signature. 216595003444 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595003445 enoyl-CoA hydratase; Region: PLN02864 216595003446 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 216595003447 active site 2 [active] 216595003448 active site 1 [active] 216595003450 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 216595003451 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595003452 NAD(P) binding site [chemical binding]; other site 216595003453 active site 216595003455 PS00061 Short-chain dehydrogenases/reductases family signature. 216595003456 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 216595003457 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 216595003458 dimer interface [polypeptide binding]; other site 216595003459 active site 216595003462 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 216595003463 ATP binding site [chemical binding]; other site 216595003465 PS00109 Tyrosine protein kinases specific active-site signature. 216595003466 PS01245 RIO1/ZK632.3/MJ0444 family signature. 216595003467 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 216595003468 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 216595003469 DNA binding residues [nucleotide binding] 216595003470 dimer interface [polypeptide binding]; other site 216595003471 copper binding site [ion binding]; other site 216595003474 PS00552 Bacterial regulatory proteins, merR family signature. 216595003475 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 216595003476 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 216595003477 metal-binding site [ion binding] 216595003478 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216595003480 PS01229 Hypothetical cof family signature 2. 216595003481 PS00154 E1-E2 ATPases phosphorylation site. 216595003484 PS01047 Heavy-metal-associated domain. 216595003485 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 216595003486 metal-binding site [ion binding] 216595003488 PS01047 Heavy-metal-associated domain. 216595003489 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595003490 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 216595003491 putative substrate translocation pore; other site 216595003492 12 probable transmembrane helices predicted for PFLU0661 by TMHMM2.0 at aa 5-26, 41-63, 70-92, 96-118, 130-152, 157-179, 207-229, 244-266, 273-295, 300-322, 335-357 and 362-384 216595003494 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 216595003495 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 216595003496 putative NAD(P) binding site [chemical binding]; other site 216595003497 dimer interface [polypeptide binding]; other site 216595003500 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 216595003502 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595003503 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595003504 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 216595003505 putative effector binding pocket; other site 216595003506 dimerization interface [polypeptide binding]; other site 216595003508 PS00044 Bacterial regulatory proteins, lysR family signature. 216595003510 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595003511 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 216595003512 active site 216595003513 purine riboside binding site [chemical binding]; other site 216595003515 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 216595003516 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 216595003517 11 probable transmembrane helices predicted for PFLU0668 by TMHMM2.0 at aa 12-29, 34-56, 69-91, 102-124, 137-154, 164-181, 211-233, 253-275, 282-301, 316-335 and 342-361 216595003519 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 216595003520 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 216595003521 active site 216595003522 putative substrate binding pocket [chemical binding]; other site 216595003524 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595003525 NAD(P) binding site [chemical binding]; other site 216595003526 active site 216595003528 Uncharacterized conserved protein [Function unknown]; Region: COG1739 216595003529 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 216595003530 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 216595003533 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 216595003534 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216595003535 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 216595003538 Permease family; Region: Xan_ur_permease; pfam00860 216595003539 Sulfate transporter family; Region: Sulfate_transp; cl00967 216595003541 PS01116 Xanthine/uracil permeases family signature. 216595003542 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595003543 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595003544 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 216595003545 dimerization interface [polypeptide binding]; other site 216595003548 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 216595003549 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 216595003550 inhibitor-cofactor binding pocket; inhibition site 216595003551 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595003552 catalytic residue [active] 216595003554 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 216595003555 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 216595003556 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 216595003557 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216595003558 tetrameric interface [polypeptide binding]; other site 216595003559 NAD binding site [chemical binding]; other site 216595003560 catalytic residues [active] 216595003562 PS00070 Aldehyde dehydrogenases cysteine active site. 216595003563 Paraquat-inducible protein A; Region: PqiA; pfam04403 216595003565 4 probable transmembrane helices predicted for PFLU0677 by TMHMM2.0 at aa 59-81, 109-131, 155-173 and 178-200 216595003566 Paraquat-inducible protein A; Region: PqiA; pfam04403 216595003568 PS00190 Cytochrome c family heme-binding site signature. 216595003569 4 probable transmembrane helices predicted for PFLU0678 by TMHMM2.0 at aa 47-69, 98-120, 141-163 and 173-191 216595003570 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 216595003571 mce related protein; Region: MCE; pfam02470 216595003572 mce related protein; Region: MCE; pfam02470 216595003573 mce related protein; Region: MCE; pfam02470 216595003574 mce related protein; Region: MCE; pfam02470 216595003575 mce related protein; Region: MCE; pfam02470 216595003576 mce related protein; Region: MCE; pfam02470 216595003577 1 probable transmembrane helix predicted for PFLU0679 by TMHMM2.0 at aa 12-34 216595003584 PS00017 ATP/GTP-binding site motif A (P-loop). 216595003585 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 216595003586 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 216595003589 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 216595003590 active site clefts [active] 216595003591 zinc binding site [ion binding]; other site 216595003592 dimer interface [polypeptide binding]; other site 216595003594 PS00705 Prokaryotic-type carbonic anhydrases signature 2. 216595003595 SET domain; Region: SET; cl02566 216595003596 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 216595003597 Sulfatase; Region: Sulfatase; cl10460 216595003599 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595003600 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 216595003602 metabolite-proton symporter; Region: 2A0106; TIGR00883 216595003603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595003604 12 probable transmembrane helices predicted for PFLU0692 by TMHMM2.0 at aa 20-42, 57-79, 92-114, 124-146, 159-181, 196-215, 246-268, 283-305, 317-339, 344-366, 373-395 and 400-422 216595003606 PS00216 Sugar transport proteins signature 1. 216595003607 PS00217 Sugar transport proteins signature 2. 216595003608 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 216595003609 Domain of unknown function (DUF955); Region: DUF955; cl01076 216595003612 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 216595003613 GntP family permease; Region: GntP_permease; cl15264 216595003614 gluconate transporter; Region: gntP; TIGR00791 216595003616 Cation efflux family; Region: Cation_efflux; cl00316 216595003617 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 216595003618 5 probable transmembrane helices predicted for PFLU0696 by TMHMM2.0 at aa 17-39, 43-65, 85-104, 119-141 and 162-181 216595003620 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 216595003621 Outer membrane efflux protein; Region: OEP; pfam02321 216595003622 Outer membrane efflux protein; Region: OEP; pfam02321 216595003623 1 probable transmembrane helix predicted for PFLU0697 by TMHMM2.0 at aa 7-29 216595003625 PS00017 ATP/GTP-binding site motif A (P-loop). 216595003627 Outer membrane efflux protein; Region: OEP; pfam02321 216595003628 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 216595003630 heavy metal efflux pump (cobalt-zinc-cadmium); Region: 2A0601; TIGR00914 216595003632 12 probable transmembrane helices predicted for PFLU0699 by TMHMM2.0 at aa 13-32, 348-365, 367-386, 396-418, 452-474, 484-506, 539-556, 883-900, 907-926, 936-958, 979-1001 and 1011-1033 216595003633 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 216595003634 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595003635 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595003636 dimer interface [polypeptide binding]; other site 216595003637 phosphorylation site [posttranslational modification] 216595003638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595003639 ATP binding site [chemical binding]; other site 216595003640 Mg2+ binding site [ion binding]; other site 216595003641 G-X-G motif; other site 216595003645 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 216595003646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595003647 active site 216595003648 phosphorylation site [posttranslational modification] 216595003649 intermolecular recognition site; other site 216595003650 dimerization interface [polypeptide binding]; other site 216595003651 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 216595003652 DNA binding site [nucleotide binding] 216595003655 outer membrane porin, OprD family; Region: OprD; pfam03573 216595003657 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 216595003658 1 probable transmembrane helix predicted for PFLU0703 by TMHMM2.0 at aa 3-25 216595003659 PAS fold; Region: PAS_4; pfam08448 216595003660 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216595003661 putative active site [active] 216595003662 heme pocket [chemical binding]; other site 216595003663 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216595003664 PAS fold; Region: PAS_3; pfam08447 216595003665 putative active site [active] 216595003666 heme pocket [chemical binding]; other site 216595003667 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595003671 Cupin domain; Region: Cupin_2; cl09118 216595003672 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216595003673 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595003677 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216595003678 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 216595003679 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 216595003680 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 216595003682 PS00843 D-alanine--D-alanine ligase signature 1. 216595003684 PS00844 D-alanine--D-alanine ligase signature 2. 216595003686 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 216595003687 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 216595003689 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595003690 Type III secretion system gene cluster 216595003691 Pathogenicity factor; Region: AvrE; pfam11725 216595003692 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 216595003693 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216595003694 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 216595003695 DNA binding residues [nucleotide binding] 216595003698 ggaaccnnnnnnnnnnnnnnnnccacnna 216595003700 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 216595003701 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 216595003702 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 216595003704 FliP family; Region: FliP; cl00593 216595003705 4 probable transmembrane helices predicted for PFLU0715 by TMHMM2.0 at aa 10-32, 53-75, 158-180 and 187-209 216595003707 PS00043 Bacterial regulatory proteins, gntR family signature. 216595003708 PS01060 Flagella transport protein fliP family signature 1. 216595003709 PS01061 Flagella transport protein fliP family signature 2. 216595003710 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 216595003712 2 probable transmembrane helices predicted for PFLU0716 by TMHMM2.0 at aa 13-35 and 45-67 216595003713 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 216595003715 6 probable transmembrane helices predicted for PFLU0717 by TMHMM2.0 at aa 10-29, 41-60, 75-97, 129-148, 183-205 and 218-240 216595003716 FlhB HrpN YscU SpaS Family; Region: Bac_export_2; pfam01312 216595003717 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017 216595003719 3 probable transmembrane helices predicted for PFLU0718 by TMHMM2.0 at aa 77-99, 143-165 and 186-208 216595003720 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595003721 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 216595003722 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 216595003723 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 216595003727 HrpE/YscL/FliH and V-type ATPase subunit E; Region: HrpE; pfam06188 216595003729 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 216595003730 1 probable transmembrane helix predicted for PFLU0726 by TMHMM2.0 at aa 228-250 216595003732 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 216595003733 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595003734 Walker A motif; other site 216595003735 ATP binding site [chemical binding]; other site 216595003736 Walker B motif; other site 216595003737 arginine finger; other site 216595003738 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 216595003741 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 216595003742 GTP-binding protein YchF; Reviewed; Region: PRK09601 216595003743 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 216595003744 G1 box; other site 216595003745 GTP/Mg2+ binding site [chemical binding]; other site 216595003746 Switch I region; other site 216595003747 G2 box; other site 216595003748 Switch II region; other site 216595003749 G3 box; other site 216595003750 G4 box; other site 216595003751 G5 box; other site 216595003752 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 216595003755 PS00017 ATP/GTP-binding site motif A (P-loop). 216595003756 PS00443 Glutamine amidotransferases class-II active site. 216595003757 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 216595003758 putative active site [active] 216595003759 catalytic residue [active] 216595003761 PS01196 Peptidyl-tRNA hydrolase signature 2. 216595003762 PS01195 Peptidyl-tRNA hydrolase signature 1. 216595003763 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 216595003764 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 216595003765 5S rRNA interface [nucleotide binding]; other site 216595003766 CTC domain interface [polypeptide binding]; other site 216595003767 L16 interface [polypeptide binding]; other site 216595003769 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK04923 216595003770 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 216595003771 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595003773 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 216595003774 PS00114 Phosphoribosyl pyrophosphate synthetase signature. 216595003775 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216595003776 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 216595003777 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 216595003780 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 216595003781 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 216595003783 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595003784 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 216595003785 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 216595003786 TPR motif; other site 216595003787 binding surface 216595003788 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 216595003789 binding surface 216595003790 TPR motif; other site 216595003793 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 216595003794 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 216595003795 tRNA; other site 216595003796 putative tRNA binding site [nucleotide binding]; other site 216595003797 putative NADP binding site [chemical binding]; other site 216595003798 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 216595003800 PS00747 Glutamyl-tRNA reductase signature. 216595003803 peptide chain release factor 1; Validated; Region: prfA; PRK00591 216595003804 RF-1 domain; Region: RF-1; cl02875 216595003805 RF-1 domain; Region: RF-1; cl02875 216595003808 PS00745 Prokaryotic-type class I peptide chain release factors signature. 216595003809 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 216595003810 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 216595003811 S-adenosylmethionine binding site [chemical binding]; other site 216595003813 PS00092 N-6 Adenine-specific DNA methylases signature. 216595003814 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 216595003815 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 216595003816 ATP binding site [chemical binding]; other site 216595003817 substrate interface [chemical binding]; other site 216595003819 1 probable transmembrane helix predicted for PFLU0740 by TMHMM2.0 at aa 32-54 216595003821 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 216595003823 PS00923 Aspartate and glutamate racemases signature 1. 216595003824 PS00924 Aspartate and glutamate racemases signature 2. 216595003825 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 216595003826 Flagellin N-methylase; Region: FliB; cl00497 216595003828 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 216595003829 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 216595003830 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 216595003831 S-adenosylmethionine binding site [chemical binding]; other site 216595003833 Protein of unknown function (DUF1365); Region: DUF1365; cl01388 216595003835 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 216595003836 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595003838 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595003839 short chain dehydrogenase; Provisional; Region: PRK06101 216595003840 NAD(P) binding site [chemical binding]; other site 216595003841 active site 216595003843 PS00061 Short-chain dehydrogenases/reductases family signature. 216595003844 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 216595003846 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 216595003847 DNA photolyase; Region: DNA_photolyase; pfam00875 216595003848 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 216595003850 PS00394 DNA photolyases class 1 signature 1. 216595003852 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 216595003853 DNA binding residues [nucleotide binding] 216595003855 Protein of unknown function (DUF523); Region: DUF523; cl00733 216595003856 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 216595003859 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216595003860 Tryptophan-rich protein (DUF2389); Region: DUF2389; cl09726 216595003861 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 216595003862 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595003865 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595003866 TIGR01777 family protein; Region: yfcH 216595003867 NAD(P) binding site [chemical binding]; other site 216595003868 active site 216595003871 ferrochelatase; Reviewed; Region: hemH; PRK00035 216595003872 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 216595003873 C-terminal domain interface [polypeptide binding]; other site 216595003874 active site 216595003875 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 216595003876 active site 216595003877 N-terminal domain interface [polypeptide binding]; other site 216595003879 PS00398 Site-specific recombinases signature 2. 216595003880 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 216595003881 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216595003882 N-terminal plug; other site 216595003883 ligand-binding site [chemical binding]; other site 216595003885 PS00017 ATP/GTP-binding site motif A (P-loop). 216595003887 serine endoprotease; Provisional; Region: PRK10898 216595003888 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 216595003889 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 216595003890 protein binding site [polypeptide binding]; other site 216595003893 1 probable transmembrane helix predicted for PFLU0758 by TMHMM2.0 at aa 7-24 216595003894 Uncharacterized conserved protein [Function unknown]; Region: COG0327 216595003895 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 216595003897 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 216595003898 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 216595003899 Active Sites [active] 216595003901 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 216595003902 CysN_ATPS subfamily. CysN, together with protein CysD, form the ATP sulfurylase (ATPS) complex in some bacteria and lower eukaryotes. ATPS catalyzes the production of ATP sulfurylase (APS) and pyrophosphate (PPi) from ATP and sulfate. CysD, which...; Region: CysN_ATPS; cd04166 216595003903 CysD dimerization site [polypeptide binding]; other site 216595003904 G1 box; other site 216595003905 putative GEF interaction site [polypeptide binding]; other site 216595003906 GTP/Mg2+ binding site [chemical binding]; other site 216595003907 Switch I region; other site 216595003908 G2 box; other site 216595003909 G3 box; other site 216595003910 Switch II region; other site 216595003911 G4 box; other site 216595003912 G5 box; other site 216595003913 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NodQ_II; cd03695 216595003914 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NoDQ_III; cd04095 216595003915 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation...; Region: APSK; cd02027 216595003916 ligand-binding site [chemical binding]; other site 216595003918 PS00017 ATP/GTP-binding site motif A (P-loop). 216595003919 PS00301 GTP-binding elongation factors signature. 216595003922 PS00017 ATP/GTP-binding site motif A (P-loop). 216595003923 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 216595003924 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 216595003925 putative acyl-acceptor binding pocket; other site 216595003927 phosphate acetyltransferase; Reviewed; Region: PRK05632 216595003928 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 216595003929 DRTGG domain; Region: DRTGG; cl12147 216595003930 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 216595003933 Protein of unknown function (DUF3565); Region: DUF3565; pfam12088 216595003934 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 216595003936 PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2. 216595003937 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 216595003939 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 216595003940 13 probable transmembrane helices predicted for PFLU0766 by TMHMM2.0 at aa 26-45, 88-110, 130-152, 159-181, 186-203, 237-259, 274-296, 309-328, 348-370, 383-405, 410-429, 441-463 and 478-500 216595003942 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 216595003943 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 216595003944 active site 216595003945 Riboflavin kinase; Region: Flavokinase; cl03312 216595003948 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 216595003949 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 216595003950 active site 216595003951 HIGH motif; other site 216595003952 nucleotide binding site [chemical binding]; other site 216595003953 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 216595003954 active site 216595003955 KMSKS motif; other site 216595003956 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 216595003957 tRNA binding surface [nucleotide binding]; other site 216595003958 anticodon binding site; other site 216595003959 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 216595003961 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 216595003962 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595003965 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 216595003966 5 probable transmembrane helices predicted for PFLU0769 by TMHMM2.0 at aa 24-43, 58-80, 87-104, 114-131 and 152-174 216595003968 PS00855 Signal peptidases II signature. 216595003969 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 216595003971 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 216595003972 PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2. 216595003973 LytB protein; Region: LYTB; cl00507 216595003974 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 216595003976 pilus (type IV secretion system) biosynthesis gene cluster. Possibly related to competence 216595003977 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 216595003978 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 216595003979 Type II transport protein GspH; Region: GspH; pfam12019 216595003980 1 probable transmembrane helix predicted for PFLU0772 by TMHMM2.0 at aa 7-29 216595003982 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 216595003983 PS00409 Prokaryotic N-terminal methylation site. 216595003984 1 probable transmembrane helix predicted for PFLU0773 by TMHMM2.0 at aa 29-51 216595003985 PS00409 Prokaryotic N-terminal methylation site. 216595003986 1 probable transmembrane helix predicted for PFLU0774 by TMHMM2.0 at aa 7-29 216595003987 1 probable transmembrane helix predicted for PFLU0775 by TMHMM2.0 at aa 12-34 216595003988 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 216595003990 PS00409 Prokaryotic N-terminal methylation site. 216595003991 1 probable transmembrane helix predicted for PFLU0776 by TMHMM2.0 at aa 10-32 216595003992 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 216595003993 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 216595003994 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 216595003996 1 probable transmembrane helix predicted for PFLU0777 by TMHMM2.0 at aa 33-55 216595003997 1 probable transmembrane helix predicted for PFLU0778 by TMHMM2.0 at aa 4-21 216595003998 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 216595003999 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595004000 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 216595004001 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 216595004002 RNA binding surface [nucleotide binding]; other site 216595004003 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 216595004004 active site 216595004007 PS01129 Rlu family of pseudouridine synthase signature. 216595004008 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 216595004009 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 216595004011 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 216595004012 Clp amino terminal domain; Region: Clp_N; pfam02861 216595004013 Clp amino terminal domain; Region: Clp_N; pfam02861 216595004014 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595004015 Walker A motif; other site 216595004016 ATP binding site [chemical binding]; other site 216595004017 Walker B motif; other site 216595004018 arginine finger; other site 216595004019 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595004020 Walker A motif; other site 216595004021 ATP binding site [chemical binding]; other site 216595004022 Walker B motif; other site 216595004023 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 216595004027 PS00017 ATP/GTP-binding site motif A (P-loop). 216595004028 PS00870 Chaperonins clpA/B signature 1. 216595004030 PS00017 ATP/GTP-binding site motif A (P-loop). 216595004031 PS00871 Chaperonins clpA/B signature 2. 216595004032 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 216595004033 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595004036 Protein of unknown function (DUF3094); Region: DUF3094; pfam11293 216595004037 1 probable transmembrane helix predicted for PFLU0784 by TMHMM2.0 at aa 41-63 216595004038 Protein of unknown function (DUF1780); Region: DUF1780; pfam08682 216595004040 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 216595004041 6 probable transmembrane helices predicted for PFLU0786 by TMHMM2.0 at aa 7-29, 44-58, 70-92, 107-129, 141-163 and 183-205 216595004042 Domain of unknown function (DUF329); Region: DUF329; cl01144 216595004044 PS00237 G-protein coupled receptors signature. 216595004045 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 216595004046 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 216595004047 CoA-binding site [chemical binding]; other site 216595004048 ATP-binding [chemical binding]; other site 216595004050 PS01294 Uncharacterized protein family UPF0038 signature. 216595004051 PS00017 ATP/GTP-binding site motif A (P-loop). 216595004052 pilus (type IV secretion system) biosynthesis gene cluster 216595004053 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 216595004054 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 216595004055 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 216595004058 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 216595004059 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 216595004060 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 216595004063 PS00874 Bacterial type II secretion system protein F signature. 216595004064 Pilin (bacterial filament); Region: Pilin; pfam00114 216595004066 PS00409 Prokaryotic N-terminal methylation site. 216595004067 1 probable transmembrane helix predicted for PFLU0793 by TMHMM2.0 at aa 10-32 216595004069 O-Antigen ligase; Region: Wzy_C; cl04850 216595004070 11 probable transmembrane helices predicted for PFLU0794 by TMHMM2.0 at aa 9-31, 36-55, 62-81, 85-107, 120-142, 162-184, 191-213, 233-255, 358-375, 385-402 and 411-433 216595004072 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05742 216595004073 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-...; Region: QPRTase; cd01572 216595004074 dimerization interface [polypeptide binding]; other site 216595004075 active site 216595004077 PS00190 Cytochrome c family heme-binding site signature. 216595004079 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793 216595004081 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 216595004082 amidase catalytic site [active] 216595004083 Zn binding residues [ion binding]; other site 216595004084 substrate binding site [chemical binding]; other site 216595004086 CobD/Cbib protein; Region: CobD_Cbib; cl00561 216595004087 5 probable transmembrane helices predicted for PFLU0799 by TMHMM2.0 at aa 45-67, 72-94, 146-168, 192-214 and 255-277 216595004088 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 216595004089 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595004090 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595004091 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595004092 2 probable transmembrane helices predicted for PFLU0800 by TMHMM2.0 at aa 15-37 and 325-347 216595004095 2 probable transmembrane helices predicted for PFLU0801 by TMHMM2.0 at aa 99-121 and 125-147 216595004096 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 216595004097 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 216595004098 active site 216595004100 PS01137 Uncharacterized protein family UPF0006 signature 1. 216595004101 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 216595004102 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216595004103 DNA binding site [nucleotide binding] 216595004104 domain linker motif; other site 216595004105 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 216595004106 dimerization interface [polypeptide binding]; other site 216595004107 ligand binding site [chemical binding]; other site 216595004110 PS00356 Bacterial regulatory proteins, lacI family signature. 216595004111 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 216595004112 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 216595004113 active site 216595004114 phosphorylation site [posttranslational modification] 216595004115 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 216595004116 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 216595004117 dimerization domain swap beta strand [polypeptide binding]; other site 216595004118 regulatory protein interface [polypeptide binding]; other site 216595004119 active site 216595004120 regulatory phosphorylation site [posttranslational modification]; other site 216595004121 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 216595004122 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 216595004123 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 216595004124 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 216595004126 PS00372 PTS EIIA domains phosphorylation site signature 2. 216595004131 PS00370 PEP-utilizing enzymes phosphorylation site signature. 216595004133 PS00742 PEP-utilizing enzymes signature 2. 216595004134 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 216595004135 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 216595004136 putative substrate binding site [chemical binding]; other site 216595004137 putative ATP binding site [chemical binding]; other site 216595004139 PS00583 pfkB family of carbohydrate kinases signature 1. 216595004140 PS00584 pfkB family of carbohydrate kinases signature 2. 216595004141 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 216595004142 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 216595004143 P-loop; other site 216595004144 active site 216595004145 phosphorylation site [posttranslational modification] 216595004146 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 216595004147 P-loop; other site 216595004148 active site 216595004149 phosphorylation site [posttranslational modification] 216595004150 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 216595004153 9 probable transmembrane helices predicted for PFLU0806 by TMHMM2.0 at aa 240-262, 282-299, 311-333, 353-375, 396-415, 435-457, 470-487, 492-514 and 534-556 216595004154 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 216595004155 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 216595004156 putative active site [active] 216595004157 putative metal binding site [ion binding]; other site 216595004158 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 216595004160 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 216595004161 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 216595004162 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 216595004163 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron...; Region: FNR_like; cl06868 216595004164 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 216595004165 FAD binding pocket [chemical binding]; other site 216595004166 FAD binding motif [chemical binding]; other site 216595004167 catalytic residues [active] 216595004168 NAD binding pocket [chemical binding]; other site 216595004169 phosphate binding motif [ion binding]; other site 216595004170 beta-alpha-beta structure motif; other site 216595004177 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 216595004178 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 216595004179 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 216595004180 active site 216595004181 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 216595004182 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 216595004184 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 216595004185 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 216595004186 dimer interface [polypeptide binding]; other site 216595004187 active site 216595004188 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 216595004189 catalytic residues [active] 216595004190 substrate binding site [chemical binding]; other site 216595004193 PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site. 216595004194 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 216595004195 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family...; Region: ABC_OpuCA_Osmoprotection; cd03295 216595004196 Walker A/P-loop; other site 216595004197 ATP binding site [chemical binding]; other site 216595004198 Q-loop/lid; other site 216595004199 ABC transporter signature motif; other site 216595004200 Walker B; other site 216595004201 D-loop; other site 216595004202 H-loop/switch region; other site 216595004203 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 216595004204 PS00017 ATP/GTP-binding site motif A (P-loop). 216595004207 PS00211 ABC transporters family signature. 216595004208 PS00017 ATP/GTP-binding site motif A (P-loop). 216595004209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 216595004211 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595004212 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 216595004213 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 216595004215 PS00583 pfkB family of carbohydrate kinases signature 1. 216595004216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595004217 dimer interface [polypeptide binding]; other site 216595004218 conserved gate region; other site 216595004219 putative PBP binding loops; other site 216595004220 ABC-ATPase subunit interface; other site 216595004222 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595004223 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595004224 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 216595004225 RF3 subfamily. Peptide chain release factor 3 (RF3) is a protein involved in the termination step of translation in bacteria. Termination occurs when class I release factors (RF1 or RF2) recognize the stop codon at the A-site of the ribosome and...; Region: RF3; cd04169 216595004226 G1 box; other site 216595004227 putative GEF interaction site [polypeptide binding]; other site 216595004228 GTP/Mg2+ binding site [chemical binding]; other site 216595004229 Switch I region; other site 216595004230 G2 box; other site 216595004231 G3 box; other site 216595004232 Switch II region; other site 216595004233 G4 box; other site 216595004234 G5 box; other site 216595004235 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 216595004237 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 216595004238 PS00301 GTP-binding elongation factors signature. 216595004240 1 probable transmembrane helix predicted for PFLU0817 by TMHMM2.0 at aa 7-29 216595004241 1 probable transmembrane helix predicted for PFLU0818 by TMHMM2.0 at aa 7-26 216595004243 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 216595004244 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 216595004245 Walker A/P-loop; other site 216595004246 ATP binding site [chemical binding]; other site 216595004247 Q-loop/lid; other site 216595004248 ABC transporter signature motif; other site 216595004249 Walker B; other site 216595004250 D-loop; other site 216595004251 H-loop/switch region; other site 216595004252 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216595004255 PS00211 ABC transporters family signature. 216595004256 PS00017 ATP/GTP-binding site motif A (P-loop). 216595004257 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 216595004258 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 216595004259 Walker A/P-loop; other site 216595004260 ATP binding site [chemical binding]; other site 216595004261 Q-loop/lid; other site 216595004262 ABC transporter signature motif; other site 216595004263 Walker B; other site 216595004264 D-loop; other site 216595004265 H-loop/switch region; other site 216595004266 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216595004269 PS00211 ABC transporters family signature. 216595004270 PS00017 ATP/GTP-binding site motif A (P-loop). 216595004271 dipeptide transporter; Provisional; Region: PRK10913 216595004272 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 216595004273 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595004274 dimer interface [polypeptide binding]; other site 216595004275 conserved gate region; other site 216595004276 putative PBP binding loops; other site 216595004277 ABC-ATPase subunit interface; other site 216595004279 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216595004280 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595004281 dimer interface [polypeptide binding]; other site 216595004282 conserved gate region; other site 216595004283 putative PBP binding loops; other site 216595004284 ABC-ATPase subunit interface; other site 216595004286 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595004287 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 216595004288 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 216595004289 peptide binding site [polypeptide binding]; other site 216595004291 outer membrane porin, OprD family; Region: OprD; pfam03573 216595004293 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 216595004294 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 216595004295 peptide binding site [polypeptide binding]; other site 216595004297 PS01040 Bacterial extracellular solute-binding proteins, family 5 signature. 216595004298 1 probable transmembrane helix predicted for PFLU0825 by TMHMM2.0 at aa 7-24 216595004299 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 216595004300 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 216595004301 peptide binding site [polypeptide binding]; other site 216595004303 PS01040 Bacterial extracellular solute-binding proteins, family 5 signature. 216595004304 1 probable transmembrane helix predicted for PFLU0826 by TMHMM2.0 at aa 12-34 216595004305 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 216595004306 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 216595004307 peptide binding site [polypeptide binding]; other site 216595004309 PS01040 Bacterial extracellular solute-binding proteins, family 5 signature. 216595004310 Protein of unknown function (DUF541); Region: SIMPL; cl01077 216595004312 1 probable transmembrane helix predicted for PFLU0828 by TMHMM2.0 at aa 7-26 216595004313 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216595004314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 216595004315 5 probable transmembrane helices predicted for PFLU0829 by TMHMM2.0 at aa 70-92, 97-119, 139-161, 174-196 and 208-230 216595004318 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 216595004319 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595004320 active site 216595004321 phosphorylation site [posttranslational modification] 216595004322 intermolecular recognition site; other site 216595004323 dimerization interface [polypeptide binding]; other site 216595004324 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 216595004327 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 216595004328 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 216595004329 Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223 216595004331 5 probable transmembrane helices predicted for PFLU0831 by TMHMM2.0 at aa 38-60, 80-102, 158-180, 185-207 and 281-303 216595004333 PS00017 ATP/GTP-binding site motif A (P-loop). 216595004334 PS00211 ABC transporters family signature. 216595004335 Protein of unknown function (DUF1043); Region: DUF1043; cl11473 216595004337 1 probable transmembrane helix predicted for PFLU0832 by TMHMM2.0 at aa 4-26 216595004338 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 216595004339 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284 216595004340 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 216595004341 active site 216595004342 HIGH motif; other site 216595004343 dimer interface [polypeptide binding]; other site 216595004344 KMSKS motif; other site 216595004346 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 216595004348 PS00017 ATP/GTP-binding site motif A (P-loop). 216595004349 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 216595004350 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 216595004351 conserved cys residue [active] 216595004352 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595004354 PS00041 Bacterial regulatory proteins, araC family signature. 216595004356 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216595004357 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216595004358 active site 216595004361 PS00072 Acyl-CoA dehydrogenases signature 1. 216595004363 PS00073 Acyl-CoA dehydrogenases signature 2. 216595004364 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 216595004365 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 216595004366 active site 216595004367 catalytic tetrad [active] 216595004369 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 216595004370 23S rRNA interface [nucleotide binding]; other site 216595004371 L3 interface [polypeptide binding]; other site 216595004373 PS00783 Ribosomal protein L13 signature. 216595004374 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 216595004376 PS00360 Ribosomal protein S9 signature. 216595004377 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 216595004378 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 216595004379 [2Fe-2S] cluster binding site [ion binding]; other site 216595004380 1 probable transmembrane helix predicted for PFLU0841 by TMHMM2.0 at aa 13-35 216595004382 PS00199 Rieske iron-sulfur protein signature 1. 216595004383 PS00200 Rieske iron-sulfur protein signature 2. 216595004384 cytochrome b; Provisional; Region: CYTB; MTH00145 216595004385 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cd00284 216595004386 Qi binding site; other site 216595004387 intrachain domain interface; other site 216595004388 interchain domain interface [polypeptide binding]; other site 216595004389 heme bH binding site [chemical binding]; other site 216595004390 heme bL binding site [chemical binding]; other site 216595004391 Qo binding site; other site 216595004392 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: cytochrome_b_C; cd00290 216595004393 interchain domain interface [polypeptide binding]; other site 216595004394 intrachain domain interface; other site 216595004395 Qi binding site; other site 216595004396 Qo binding site; other site 216595004398 9 probable transmembrane helices predicted for PFLU0842 by TMHMM2.0 at aa 34-56, 83-105, 118-140, 145-164, 185-207, 246-263, 308-327, 344-363 and 370-392 216595004400 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 216595004401 PS00190 Cytochrome c family heme-binding site signature. 216595004402 1 probable transmembrane helix predicted for PFLU0843 by TMHMM2.0 at aa 232-250 216595004403 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 216595004404 stringent starvation protein A; Provisional; Region: sspA; PRK09481 216595004405 C-terminal domain interface [polypeptide binding]; other site 216595004406 putative GSH binding site (G-site) [chemical binding]; other site 216595004407 dimer interface [polypeptide binding]; other site 216595004408 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 216595004409 dimer interface [polypeptide binding]; other site 216595004410 N-terminal domain interface [polypeptide binding]; other site 216595004413 Stringent starvation protein B; Region: SspB; cl01120 216595004415 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216595004416 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595004417 DNA-binding site [nucleotide binding]; DNA binding site 216595004418 FCD domain; Region: FCD; cl11656 216595004421 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 216595004422 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 216595004423 putative active site [active] 216595004424 catalytic residue [active] 216595004426 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 216595004427 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216595004428 NAD(P) binding site [chemical binding]; other site 216595004429 catalytic residues [active] 216595004431 PS00687 Aldehyde dehydrogenases glutamic acid active site. 216595004432 PS00070 Aldehyde dehydrogenases cysteine active site. 216595004433 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595004434 D-galactonate transporter; Region: 2A0114; TIGR00893 216595004435 putative substrate translocation pore; other site 216595004436 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595004437 12 probable transmembrane helices predicted for PFLU0851 by TMHMM2.0 at aa 12-34, 49-71, 78-97, 102-124, 145-167, 171-193, 247-269, 284-303, 316-338, 343-365, 378-400 and 410-429 216595004439 galactarate dehydratase; Region: galactar-dH20; TIGR03248 216595004440 SAF domain; Region: SAF; cl00555 216595004441 SAF domain; Region: SAF; cl00555 216595004444 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 216595004445 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 216595004446 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 216595004447 putative acyl-acceptor binding pocket; other site 216595004448 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 216595004449 Membrane transport protein; Region: Mem_trans; cl09117 216595004450 10 probable transmembrane helices predicted for PFLU0856 by TMHMM2.0 at aa 4-26, 39-58, 68-90, 103-122, 132-154, 166-188, 198-220, 227-249, 253-275 and 284-306 216595004452 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 216595004454 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 216595004455 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 216595004458 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 216595004460 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595004462 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 216595004463 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 216595004464 GatB domain; Region: GatB_Yqey; cl11497 216595004468 PS01234 PET112 family signature. 216595004469 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 216595004470 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 216595004472 PS00571 Amidases signature. 216595004473 PS00017 ATP/GTP-binding site motif A (P-loop). 216595004474 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 216595004476 rod shape-determining protein MreB; Provisional; Region: PRK13927 216595004477 Cell division protein FtsA; Region: FtsA; cl11496 216595004479 rod shape-determining protein MreC; Region: MreC; pfam04085 216595004480 1 probable transmembrane helix predicted for PFLU0864 by TMHMM2.0 at aa 5-24 216595004482 rod shape-determining protein MreD; Region: MreD; cl01087 216595004484 4 probable transmembrane helices predicted for PFLU0865 by TMHMM2.0 at aa 9-31, 69-91, 104-126 and 130-152 216595004485 Maf-like protein; Region: Maf; pfam02545 216595004486 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 216595004487 active site 216595004488 dimer interface [polypeptide binding]; other site 216595004490 ribonuclease G; Provisional; Region: PRK11712 216595004491 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 216595004492 homodimer interface [polypeptide binding]; other site 216595004493 oligonucleotide binding site [chemical binding]; other site 216595004495 TIGR02099 family protein; Region: TIGR02099 216595004496 2 probable transmembrane helices predicted for PFLU0868 by TMHMM2.0 at aa 7-29 and 1215-1234 216595004497 PS00041 Bacterial regulatory proteins, araC family signature. 216595004498 Predicted amidohydrolase [General function prediction only]; Region: COG0388 216595004499 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 216595004500 putative active site [active] 216595004501 catalytic triad [active] 216595004502 dimer interface [polypeptide binding]; other site 216595004504 PS01227 Uncharacterized protein family UPF0012 signature. 216595004505 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 216595004506 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 216595004508 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 216595004509 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 216595004511 fumarate hydratase; Reviewed; Region: fumC; PRK00485 216595004512 Class II fumarases; Region: Fumarase_classII; cd01362 216595004513 active site 216595004514 tetramer interface [polypeptide binding]; other site 216595004516 PS00163 Fumarate lyases signature. 216595004517 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 216595004518 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 216595004519 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 216595004522 PS00088 Manganese and iron superoxide dismutases signature. 216595004523 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 216595004524 ZIP Zinc transporter; Region: Zip; pfam02535 216595004525 9 probable transmembrane helices predicted for PFLU0877 by TMHMM2.0 at aa 13-35, 45-67, 79-101, 111-130, 156-178, 188-210, 217-239, 244-266 and 279-296 216595004527 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 216595004528 dimerization domain swap beta strand [polypeptide binding]; other site 216595004529 regulatory protein interface [polypeptide binding]; other site 216595004530 active site 216595004531 regulatory phosphorylation site [posttranslational modification]; other site 216595004533 PS00369 PTS HPR component histidine phosphorylation site signature. 216595004534 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595004536 PS00017 ATP/GTP-binding site motif A (P-loop). 216595004537 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 216595004538 active site 216595004539 phosphorylation site [posttranslational modification] 216595004541 PS00372 PTS EIIA domains phosphorylation site signature 2. 216595004542 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552 216595004543 30S subunit binding site; other site 216595004545 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 216595004546 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 216595004547 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 216595004548 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 216595004550 PS00718 Sigma-54 factors family signature 2. 216595004551 PS00717 Sigma-54 factors family signature 1. 216595004554 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 216595004555 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 216595004556 Walker A/P-loop; other site 216595004557 ATP binding site [chemical binding]; other site 216595004558 Q-loop/lid; other site 216595004559 ABC transporter signature motif; other site 216595004560 Walker B; other site 216595004561 D-loop; other site 216595004562 H-loop/switch region; other site 216595004564 PS00211 ABC transporters family signature. 216595004565 PS00017 ATP/GTP-binding site motif A (P-loop). 216595004566 OstA-like protein; Region: OstA; cl00844 216595004568 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 216595004569 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 216595004571 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 216595004573 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 216595004574 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-...; Region: SIS_Kpsf; cd05014 216595004575 putative active site [active] 216595004576 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 216595004579 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 216595004580 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 216595004581 Walker A/P-loop; other site 216595004582 ATP binding site [chemical binding]; other site 216595004583 Q-loop/lid; other site 216595004584 ABC transporter signature motif; other site 216595004585 Walker B; other site 216595004586 D-loop; other site 216595004587 H-loop/switch region; other site 216595004589 PS00017 ATP/GTP-binding site motif A (P-loop). 216595004590 PS00211 ABC transporters family signature. 216595004591 Domain of unknown function DUF140; Region: DUF140; cl00510 216595004592 5 probable transmembrane helices predicted for PFLU0889 by TMHMM2.0 at aa 12-34, 54-76, 152-174, 201-223 and 243-262 216595004594 mce related protein; Region: MCE; pfam02470 216595004595 2 probable transmembrane helices predicted for PFLU0890 by TMHMM2.0 at aa 7-29 and 49-71 216595004597 ABC-type transport system involved in resistance to organic solvents, auxiliary component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2D; cl01074 216595004598 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 216595004600 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 216595004601 anti sigma factor interaction site; other site 216595004602 regulatory phosphorylation site [posttranslational modification]; other site 216595004604 BolA-like protein; Region: BolA; cl00386 216595004606 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 216595004607 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 216595004608 hinge; other site 216595004609 active site 216595004611 ATP phosphoribosyltransferase; Region: HisG; cl15266 216595004613 PS01316 ATP phosphoribosyltransferase signature. 216595004614 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 216595004615 E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572 216595004616 NAD binding site [chemical binding]; other site 216595004617 dimerization interface [polypeptide binding]; other site 216595004618 product binding site; other site 216595004619 substrate binding site [chemical binding]; other site 216595004620 zinc binding site [ion binding]; other site 216595004621 catalytic residues [active] 216595004623 PS00017 ATP/GTP-binding site motif A (P-loop). 216595004624 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 216595004625 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216595004626 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595004627 homodimer interface [polypeptide binding]; other site 216595004628 catalytic residue [active] 216595004630 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 216595004631 Sulfate transporter family; Region: Sulfate_transp; cl00967 216595004632 Permease family; Region: Xan_ur_permease; pfam00860 216595004634 PS01116 Xanthine/uracil permeases family signature. 216595004635 PS00017 ATP/GTP-binding site motif A (P-loop). 216595004636 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 216595004638 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 216595004640 PS00213 Lipocalin signature. 216595004641 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 216595004642 Predicted dehydrogenase [General function prediction only]; Region: COG0579 216595004644 1 probable transmembrane helix predicted for PFLU0904 by TMHMM2.0 at aa 7-24 216595004645 hypothetical protein; Provisional; Region: PRK11627 216595004646 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 216595004647 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595004648 2 probable transmembrane helices predicted for PFLU0910 by TMHMM2.0 at aa 4-26 and 63-82 216595004649 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595004650 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 216595004651 putative acyl-acceptor binding pocket; other site 216595004653 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 216595004655 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595004656 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595004657 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595004660 Peptidase family M48; Region: Peptidase_M48; cl12018 216595004661 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595004663 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 216595004664 Predicted membrane protein [Function unknown]; Region: COG2119 216595004665 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 216595004666 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 216595004668 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 216595004669 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 216595004670 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 216595004671 S-adenosylmethionine binding site [chemical binding]; other site 216595004673 PS00092 N-6 Adenine-specific DNA methylases signature. 216595004675 glycerate dehydrogenase; Provisional; Region: PRK06487 216595004676 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595004679 PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 216595004680 LysE type translocator; Region: LysE; cl00565 216595004681 5 probable transmembrane helices predicted for PFLU0921 by TMHMM2.0 at aa 24-46, 82-104, 152-174, 184-206 and 219-241 216595004683 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 216595004684 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595004686 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 216595004688 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 216595004690 PS00904 Protein prenyltransferases alpha subunit repeat signature. 216595004692 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 216595004693 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 216595004694 DNA binding residues [nucleotide binding] 216595004695 dimerization interface [polypeptide binding]; other site 216595004696 PS00017 ATP/GTP-binding site motif A (P-loop). 216595004698 PS00622 Bacterial regulatory proteins, luxR family signature. 216595004699 Protein of unknown function (DUF330); Region: DUF330; cl01135 216595004701 PS00430 TonB-dependent receptor proteins signature 1. 216595004702 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595004703 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 216595004704 mce related protein; Region: MCE; pfam02470 216595004705 mce related protein; Region: MCE; pfam02470 216595004706 mce related protein; Region: MCE; pfam02470 216595004710 1 probable transmembrane helix predicted for PFLU0927 by TMHMM2.0 at aa 26-48 216595004711 Paraquat-inducible protein A; Region: PqiA; pfam04403 216595004713 Paraquat-inducible protein A; Region: PqiA; pfam04403 216595004715 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 216595004717 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216595004718 ligand binding site [chemical binding]; other site 216595004720 PS01068 OmpA-like domain. 216595004721 outer membrane lipoprotein; Provisional; Region: PRK11023 216595004722 BON domain; Region: BON; cl02771 216595004725 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595004726 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 216595004727 dimer interface [polypeptide binding]; other site 216595004728 active site 216595004730 LppC putative lipoprotein; Region: LppC; pfam04348 216595004731 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 216595004732 putative ligand binding site [chemical binding]; other site 216595004734 PS00041 Bacterial regulatory proteins, araC family signature. 216595004735 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595004736 Predicted methyltransferases [General function prediction only]; Region: COG0313 216595004737 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 216595004739 PS01296 Uncharacterized protein family UPF0011 signature. 216595004740 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 216595004741 MraZ protein; Region: MraZ; pfam02381 216595004742 MraZ protein; Region: MraZ; pfam02381 216595004745 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 216595004746 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 216595004748 Septum formation initiator; Region: DivIC; cl11433 216595004750 1 probable transmembrane helix predicted for PFLU0940 by TMHMM2.0 at aa 10-32 216595004751 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 216595004752 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 216595004753 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 216595004754 1 probable transmembrane helix predicted for PFLU0941 by TMHMM2.0 at aa 13-32 216595004757 PS00017 ATP/GTP-binding site motif A (P-loop). 216595004758 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 216595004759 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 216595004760 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 216595004761 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 216595004765 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 216595004766 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 216595004767 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 216595004768 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 216595004772 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 216595004773 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852 216595004774 Mg++ binding site [ion binding]; other site 216595004775 putative catalytic motif [active] 216595004776 putative substrate binding site [chemical binding]; other site 216595004777 10 probable transmembrane helices predicted for PFLU0944 by TMHMM2.0 at aa 21-43, 71-90, 97-114, 134-156, 168-185, 200-222, 229-251, 261-283, 288-310 and 338-357 216595004779 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 216595004780 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 216595004782 PS00012 Phosphopantetheine attachment site. 216595004784 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 216595004785 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 216595004787 10 probable transmembrane helices predicted for PFLU0946 by TMHMM2.0 at aa 26-48, 63-85, 90-110, 125-147, 159-176, 180-202, 204-226, 289-311, 323-345 and 355-377 216595004788 PS00428 Cell cycle proteins ftsW / rodA / spoVE signature. 216595004789 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 216595004790 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785 216595004791 active site 216595004792 homodimer interface [polypeptide binding]; other site 216595004795 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 216595004796 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 216595004797 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 216595004798 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 216595004800 1 probable transmembrane helix predicted for PFLU0948 by TMHMM2.0 at aa 21-43 216595004803 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 216595004804 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 216595004805 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 216595004807 PS00017 ATP/GTP-binding site motif A (P-loop). 216595004808 PS00843 D-alanine--D-alanine ligase signature 1. 216595004810 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 216595004811 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 216595004812 Cell division protein FtsQ; Region: FtsQ; pfam03799 216595004813 1 probable transmembrane helix predicted for PFLU0950 by TMHMM2.0 at aa 39-61 216595004816 cell division protein FtsA; Region: ftsA; TIGR01174 216595004817 Cell division protein FtsA; Region: FtsA; cl11496 216595004818 Cell division protein FtsA; Region: FtsA; cl11496 216595004821 cell division protein FtsZ; Validated; Region: PRK09330 216595004822 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201 216595004823 nucleotide binding site [chemical binding]; other site 216595004824 SulA interaction site; other site 216595004826 PS01134 FtsZ protein signature 1. 216595004827 PS01135 FtsZ protein signature 2. 216595004829 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 216595004830 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 216595004833 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216595004834 metal binding site [ion binding]; metal-binding site 216595004835 active site 216595004836 I-site; other site 216595004838 outer membrane porin, OprD family; Region: OprD; pfam03573 216595004840 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 216595004841 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595004842 dimer interface [polypeptide binding]; other site 216595004843 phosphorylation site [posttranslational modification] 216595004844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595004845 ATP binding site [chemical binding]; other site 216595004846 Mg2+ binding site [ion binding]; other site 216595004847 G-X-G motif; other site 216595004851 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 216595004852 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595004853 active site 216595004854 phosphorylation site [posttranslational modification] 216595004855 intermolecular recognition site; other site 216595004856 dimerization interface [polypeptide binding]; other site 216595004857 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 216595004858 DNA binding site [nucleotide binding] 216595004861 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 216595004863 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 216595004865 1 probable transmembrane helix predicted for PFLU0961 by TMHMM2.0 at aa 31-48 216595004866 PS00583 pfkB family of carbohydrate kinases signature 1. 216595004867 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216595004868 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595004869 substrate binding pocket [chemical binding]; other site 216595004870 membrane-bound complex binding site; other site 216595004871 hinge residues; other site 216595004873 Flagellin N-methylase; Region: FliB; cl00497 216595004874 Pyrimidine 5'-nucleotidase (UMPH-1); Region: UMPH-1; pfam05822 216595004876 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 216595004878 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 216595004879 Response regulator receiver domain; Region: Response_reg; pfam00072 216595004880 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595004881 active site 216595004882 phosphorylation site [posttranslational modification] 216595004883 intermolecular recognition site; other site 216595004884 dimerization interface [polypeptide binding]; other site 216595004887 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 216595004888 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595004891 PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 216595004892 PS00017 ATP/GTP-binding site motif A (P-loop). 216595004893 transcriptional regulator; Provisional; Region: PRK10632 216595004894 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595004895 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 216595004896 putative effector binding pocket; other site 216595004897 dimerization interface [polypeptide binding]; other site 216595004900 PS00044 Bacterial regulatory proteins, lysR family signature. 216595004901 NodT family; Region: outer_NodT; TIGR01845 216595004902 Outer membrane efflux protein; Region: OEP; pfam02321 216595004903 Outer membrane efflux protein; Region: OEP; pfam02321 216595004904 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595004907 Fusaric acid resistance protein family; Region: FUSC; pfam04632 216595004908 Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136 216595004909 Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136 216595004910 11 probable transmembrane helices predicted for PFLU0971 by TMHMM2.0 at aa 30-52, 79-101, 106-123, 130-149, 159-181, 393-415, 420-439, 446-468, 473-492, 497-514 and 529-548 216595004912 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 216595004914 2 probable transmembrane helices predicted for PFLU0972 by TMHMM2.0 at aa 7-29 and 42-64 216595004915 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 216595004916 1 probable transmembrane helix predicted for PFLU0973 by TMHMM2.0 at aa 4-26 216595004918 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 216595004919 short chain dehydrogenase; Provisional; Region: PRK05693 216595004920 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 216595004921 NADP binding site [chemical binding]; other site 216595004922 active site 216595004923 steroid binding site; other site 216595004925 PS00061 Short-chain dehydrogenases/reductases family signature. 216595004926 ggaaccnnnnnnnnnnnnnnnnccacnna 216595004927 ggaaccnnnnnnnnnnnnnnnnccacnna 216595004928 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 216595004929 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 216595004930 Substrate binding site [chemical binding]; other site 216595004931 Cupin domain; Region: Cupin_2; cl09118 216595004934 Alginate O-acetyl transferase AlgF; Region: AlgF; pfam11182 216595004935 1 probable transmembrane helix predicted for PFLU0980 by TMHMM2.0 at aa 13-35 216595004936 1 probable transmembrane helix predicted for PFLU0981 by TMHMM2.0 at aa 7-25 216595004937 MBOAT family; Region: MBOAT; cl00738 216595004939 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cd00244 216595004940 active site 216595004942 Domain present in carbohydrate binding proteins and sugar hydrolses; Region: CASH; smart00722 216595004943 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 216595004944 Sel1 repeat; Region: Sel1; cl02723 216595004947 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595004948 PilZ domain; Region: PilZ; cl01260 216595004949 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 216595004950 1 probable transmembrane helix predicted for PFLU0988 by TMHMM2.0 at aa 158-177 216595004952 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 216595004953 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 216595004954 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595004955 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 216595004956 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595004959 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 216595004961 Protein of unknown function (DUF328); Region: DUF328; cl01143 216595004963 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 216595004964 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 216595004966 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 216595004967 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 216595004968 putative active site [active] 216595004969 PhoH-like protein; Region: PhoH; cl12134 216595004971 PS00017 ATP/GTP-binding site motif A (P-loop). 216595004972 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a...; Region: MoaC_PE; cd01420 216595004973 trimer interface [polypeptide binding]; other site 216595004974 dimer interface [polypeptide binding]; other site 216595004975 putative active site [active] 216595004977 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 216595004978 MoaE interaction surface [polypeptide binding]; other site 216595004979 MoeB interaction surface [polypeptide binding]; other site 216595004980 thiocarboxylated glycine; other site 216595004982 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 216595004983 MoaE homodimer interface [polypeptide binding]; other site 216595004984 MoaD interaction [polypeptide binding]; other site 216595004985 active site residues [active] 216595004987 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 216595004988 DEAD-like helicases superfamily; Region: DEXDc; smart00487 216595004989 ATP binding site [chemical binding]; other site 216595004990 Mg++ binding site [ion binding]; other site 216595004991 motif III; other site 216595004992 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216595004993 nucleotide binding region [chemical binding]; other site 216595004994 ATP-binding site [chemical binding]; other site 216595004997 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 216595004998 PS00017 ATP/GTP-binding site motif A (P-loop). 216595004999 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 216595005000 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595005002 PS00237 G-protein coupled receptors signature. 216595005003 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595005004 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 216595005005 substrate binding pocket [chemical binding]; other site 216595005006 membrane-bound complex binding site; other site 216595005007 hinge residues; other site 216595005008 1 probable transmembrane helix predicted for PFLU1000 by TMHMM2.0 at aa 7-29 216595005009 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 216595005010 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 216595005011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595005012 dimer interface [polypeptide binding]; other site 216595005013 ABC-ATPase subunit interface; other site 216595005014 putative PBP binding loops; other site 216595005015 8 probable transmembrane helices predicted for PFLU1001 by TMHMM2.0 at aa 21-40, 87-109, 130-152, 182-204, 217-239, 254-276, 333-352 and 362-384 216595005017 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595005018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595005019 dimer interface [polypeptide binding]; other site 216595005020 conserved gate region; other site 216595005021 putative PBP binding loops; other site 216595005022 ABC-ATPase subunit interface; other site 216595005023 8 probable transmembrane helices predicted for PFLU1002 by TMHMM2.0 at aa 35-57, 97-116, 123-145, 155-177, 198-220, 230-249, 289-311 and 326-348 216595005025 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595005026 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 216595005027 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 216595005028 Walker A/P-loop; other site 216595005029 ATP binding site [chemical binding]; other site 216595005030 Q-loop/lid; other site 216595005031 ABC transporter signature motif; other site 216595005032 Walker B; other site 216595005033 D-loop; other site 216595005034 H-loop/switch region; other site 216595005036 PS00017 ATP/GTP-binding site motif A (P-loop). 216595005037 PS00211 ABC transporters family signature. 216595005038 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 216595005039 YgiT-type zinc finger domain; Region: YgiT_finger; TIGR03831 216595005040 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 216595005041 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216595005042 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595005043 DNA-binding site [nucleotide binding]; DNA binding site 216595005044 FCD domain; Region: FCD; cl11656 216595005046 PS00043 Bacterial regulatory proteins, gntR family signature. 216595005048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595005049 putative substrate translocation pore; other site 216595005050 12 probable transmembrane helices predicted for PFLU1007 by TMHMM2.0 at aa 37-59, 74-96, 103-122, 127-149, 161-180, 190-212, 233-255, 270-292, 299-321, 325-347, 354-376 and 391-413 216595005052 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 216595005054 hypothetical protein; Provisional; Region: PRK15301 216595005055 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 216595005057 PS00017 ATP/GTP-binding site motif A (P-loop). 216595005058 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 216595005059 pilin outer membrane usher protein SafC; Provisional; Region: PRK15223; cl14650 216595005061 PS01151 Fimbrial biogenesis outer membrane usher protein signature. 216595005062 putative fimbrial chaperone protein; Provisional; Region: PRK09918 216595005063 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 216595005064 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 216595005067 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595005068 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 216595005070 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 216595005072 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 216595005074 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 216595005076 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 216595005078 Response regulator receiver domain; Region: Response_reg; pfam00072 216595005079 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595005080 active site 216595005081 phosphorylation site [posttranslational modification] 216595005082 intermolecular recognition site; other site 216595005083 dimerization interface [polypeptide binding]; other site 216595005086 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216595005087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595005088 active site 216595005089 phosphorylation site [posttranslational modification] 216595005090 intermolecular recognition site; other site 216595005091 dimerization interface [polypeptide binding]; other site 216595005092 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 216595005093 DNA binding residues [nucleotide binding] 216595005094 dimerization interface [polypeptide binding]; other site 216595005097 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 216595005099 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 216595005100 GIY-YIG motif/motif A; other site 216595005101 putative active site [active] 216595005102 putative metal binding site [ion binding]; other site 216595005104 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 216595005105 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 216595005106 C-terminal domain interface [polypeptide binding]; other site 216595005107 GSH binding site (G-site) [chemical binding]; other site 216595005108 dimer interface [polypeptide binding]; other site 216595005109 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 216595005110 N-terminal domain interface [polypeptide binding]; other site 216595005111 Secretin and TonB N terminus short domain; Region: STN; cl06624 216595005112 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 216595005113 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216595005114 N-terminal plug; other site 216595005115 ligand-binding site [chemical binding]; other site 216595005119 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 216595005120 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl15297 216595005121 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595005123 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595005124 Transcriptional regulator [Transcription]; Region: IclR; COG1414 216595005125 Bacterial transcriptional regulator; Region: IclR; pfam01614 216595005128 homogentisate 1,2-dioxygenase; Region: HgmA; cl10473 216595005130 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 216595005131 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 216595005132 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 216595005135 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_N_Zeta; cd03042 216595005136 maleylacetoacetate isomerase; Region: maiA; TIGR01262 216595005137 C-terminal domain interface [polypeptide binding]; other site 216595005138 GSH binding site (G-site) [chemical binding]; other site 216595005139 putative dimer interface [polypeptide binding]; other site 216595005140 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 216595005141 N-terminal domain interface [polypeptide binding]; other site 216595005142 dimer interface [polypeptide binding]; other site 216595005143 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 216595005145 benzoate transport; Region: 2A0115; TIGR00895 216595005146 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595005147 putative substrate translocation pore; other site 216595005148 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595005149 12 probable transmembrane helices predicted for PFLU1028 by TMHMM2.0 at aa 22-44, 59-78, 90-109, 114-136, 149-171, 176-198, 259-278, 293-315, 324-343, 353-375, 388-410 and 414-431 216595005151 Uncharacterized conserved protein [Function unknown]; Region: COG2912 216595005152 hypothetical protein; Provisional; Region: PRK10941 216595005153 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 216595005154 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 216595005155 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 216595005156 NAD binding site [chemical binding]; other site 216595005157 Phe binding site; other site 216595005160 YebG protein; Region: YebG; cl01217 216595005162 Phosphate-starvation-inducible E; Region: PsiE; cl01264 216595005164 4 probable transmembrane helices predicted for PFLU1032 by TMHMM2.0 at aa 30-52, 62-79, 86-103 and 113-135 216595005165 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 216595005166 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 216595005167 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 216595005168 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 216595005169 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 216595005170 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 216595005173 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595005174 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 216595005175 HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 216595005176 dimerization interface [polypeptide binding]; other site 216595005177 substrate binding pocket [chemical binding]; other site 216595005179 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 216595005181 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552 216595005182 30S subunit binding site; other site 216595005183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595005184 putative substrate translocation pore; other site 216595005186 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595005187 LysR family transcriptional regulator; Provisional; Region: PRK14997 216595005188 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 216595005189 putative effector binding pocket; other site 216595005190 putative dimerization interface [polypeptide binding]; other site 216595005192 PS00044 Bacterial regulatory proteins, lysR family signature. 216595005194 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 216595005195 Secretin and TonB N terminus short domain; Region: STN; cl06624 216595005196 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216595005197 N-terminal plug; other site 216595005198 ligand-binding site [chemical binding]; other site 216595005200 PS01156 TonB-dependent receptor proteins signature 2. 216595005203 fec operon regulator FecR; Reviewed; Region: PRK09774 216595005204 FecR protein; Region: FecR; pfam04773 216595005206 RNA polymerase sigma factor; Provisional; Region: PRK12528 216595005207 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216595005208 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 216595005211 3 probable transmembrane helices predicted for PFLU1043 by TMHMM2.0 at aa 31-53, 58-80 and 87-109 216595005212 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 216595005214 8 probable transmembrane helices predicted for PFLU1044 by TMHMM2.0 at aa 12-34, 141-163, 190-212, 342-364, 385-404, 419-436, 443-465 and 480-499 216595005218 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 216595005219 3 probable transmembrane helices predicted for PFLU1045 by TMHMM2.0 at aa 37-59, 63-81 and 88-107 216595005220 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 216595005221 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216595005222 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 216595005223 DNA binding residues [nucleotide binding] 216595005226 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 216595005227 FecR protein; Region: FecR; pfam04773 216595005228 1 probable transmembrane helix predicted for PFLU1047 by TMHMM2.0 at aa 86-108 216595005230 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide...; Region: NrdH; cd02976 216595005231 catalytic residues [active] 216595005233 PS00194 Thioredoxin family active site. 216595005234 Nucleoid-associated protein [General function prediction only]; Region: COG3081 216595005235 nucleoid-associated protein NdpA; Validated; Region: PRK00378 216595005237 PS00847 MCM family signature. 216595005238 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 216595005239 IHF - DNA interface [nucleotide binding]; other site 216595005240 IHF dimer interface [polypeptide binding]; other site 216595005242 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 216595005243 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 216595005245 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 216595005246 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 216595005247 HIGH motif; other site 216595005248 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 216595005249 active site 216595005250 KMSKS motif; other site 216595005251 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 216595005252 tRNA binding surface [nucleotide binding]; other site 216595005253 anticodon binding site; other site 216595005254 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 216595005257 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 216595005258 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 216595005260 multifunctional aminopeptidase A; Provisional; Region: PRK00913 216595005261 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 216595005262 interface (dimer of trimers) [polypeptide binding]; other site 216595005263 Substrate-binding/catalytic site; other site 216595005264 Zn-binding sites [ion binding]; other site 216595005266 PS00631 Cytosol aminopeptidase signature. 216595005268 PS00017 ATP/GTP-binding site motif A (P-loop). 216595005269 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 216595005270 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 216595005272 6 probable transmembrane helices predicted for PFLU1056 by TMHMM2.0 at aa 13-35, 61-80, 101-123, 276-298, 305-327 and 337-359 216595005273 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 216595005274 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 216595005276 6 probable transmembrane helices predicted for PFLU1057 by TMHMM2.0 at aa 7-29, 63-85, 98-120, 238-260, 273-295 and 333-355 216595005277 PS00107 Protein kinases ATP-binding region signature. 216595005278 GTP-binding protein LepA; Provisional; Region: PRK05433 216595005279 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 216595005280 G1 box; other site 216595005281 putative GEF interaction site [polypeptide binding]; other site 216595005282 GTP/Mg2+ binding site [chemical binding]; other site 216595005283 Switch I region; other site 216595005284 G2 box; other site 216595005285 G3 box; other site 216595005286 Switch II region; other site 216595005287 G4 box; other site 216595005288 G5 box; other site 216595005289 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699 216595005290 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 216595005291 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 216595005293 PS00017 ATP/GTP-binding site motif A (P-loop). 216595005297 signal peptidase I; Provisional; Region: PRK10861 216595005298 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 216595005299 Catalytic site [active] 216595005300 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 216595005301 2 probable transmembrane helices predicted for PFLU1059 by TMHMM2.0 at aa 5-27 and 59-81 216595005303 PS00501 Signal peptidases I serine active site. 216595005304 PS00760 Signal peptidases I lysine active site. 216595005305 PS00761 Signal peptidases I signature 3. 216595005306 ribonuclease III; Reviewed; Region: rnc; PRK00102 216595005307 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 216595005308 dimerization interface [polypeptide binding]; other site 216595005309 active site 216595005310 metal binding site [ion binding]; metal-binding site 216595005311 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048 216595005312 dsRNA binding site [nucleotide binding]; other site 216595005314 PS00517 Ribonuclease III family signature. 216595005316 GTPase Era; Reviewed; Region: era; PRK00089 216595005317 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 216595005318 G1 box; other site 216595005319 GTP/Mg2+ binding site [chemical binding]; other site 216595005320 Switch I region; other site 216595005321 G2 box; other site 216595005322 Switch II region; other site 216595005323 G3 box; other site 216595005324 G4 box; other site 216595005325 G5 box; other site 216595005326 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 216595005328 PS00017 ATP/GTP-binding site motif A (P-loop). 216595005330 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 216595005331 Recombination protein O N terminal; Region: RecO_N; pfam11967 216595005332 Recombination protein O C terminal; Region: RecO_C; pfam02565 216595005334 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 216595005335 active site 216595005336 hydrophilic channel; other site 216595005337 dimerization interface [polypeptide binding]; other site 216595005338 catalytic residues [active] 216595005339 active site lid [active] 216595005341 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 216595005342 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 216595005343 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 216595005344 1 probable transmembrane helix predicted for PFLU1064 by TMHMM2.0 at aa 31-53 216595005347 PS00017 ATP/GTP-binding site motif A (P-loop). 216595005348 PS00079 Multicopper oxidases signature 1. 216595005349 PS00080 Multicopper oxidases signature 2. 216595005350 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 216595005351 nucleoside/Zn binding site; other site 216595005352 dimer interface [polypeptide binding]; other site 216595005353 catalytic motif [active] 216595005355 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 216595005356 tRNA mo(5)U34 methyltransferase; Provisional; Region: PRK15068 216595005357 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 216595005358 S-adenosylmethionine binding site [chemical binding]; other site 216595005360 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 216595005361 S-adenosylmethionine binding site [chemical binding]; other site 216595005363 YhhN-like protein; Region: YhhN; cl01505 216595005365 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; cl02325 216595005366 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595005367 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 216595005368 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595005369 Walker A motif; other site 216595005370 ATP binding site [chemical binding]; other site 216595005371 Walker B motif; other site 216595005372 arginine finger; other site 216595005373 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 216595005375 PS01046 ATP-dependent serine proteases, lon family, serine active site. 216595005377 PS00017 ATP/GTP-binding site motif A (P-loop). 216595005379 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595005380 DNA-binding site [nucleotide binding]; DNA binding site 216595005381 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595005382 DNA-binding site [nucleotide binding]; DNA binding site 216595005383 FCD domain; Region: FCD; cl11656 216595005387 PS00043 Bacterial regulatory proteins, gntR family signature. 216595005388 hypothetical protein; Provisional; Region: PRK06102 216595005389 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 216595005391 PS00017 ATP/GTP-binding site motif A (P-loop). 216595005392 PS00571 Amidases signature. 216595005393 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 216595005394 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 216595005396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595005397 benzoate transport; Region: 2A0115; TIGR00895 216595005398 putative substrate translocation pore; other site 216595005399 10 probable transmembrane helices predicted for PFLU1074 by TMHMM2.0 at aa 33-55, 70-92, 165-187, 191-210, 269-291, 306-328, 335-357, 361-383, 395-417 and 427-449 216595005401 PS00216 Sugar transport proteins signature 1. 216595005402 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595005403 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216595005404 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595005405 NAD(P) binding site [chemical binding]; other site 216595005406 active site 216595005408 PS00061 Short-chain dehydrogenases/reductases family signature. 216595005409 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595005410 NAD(P) binding site [chemical binding]; other site 216595005411 active site 216595005413 PS00061 Short-chain dehydrogenases/reductases family signature. 216595005414 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 216595005415 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 216595005416 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 216595005418 PS00017 ATP/GTP-binding site motif A (P-loop). 216595005420 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 216595005422 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 216595005423 dimerization interface [polypeptide binding]; other site 216595005424 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216595005425 metal binding site [ion binding]; metal-binding site 216595005426 active site 216595005427 I-site; other site 216595005428 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216595005432 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595005433 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216595005434 metal binding site [ion binding]; metal-binding site 216595005435 active site 216595005436 I-site; other site 216595005437 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216595005438 2 probable transmembrane helices predicted for PFLU1083 by TMHMM2.0 at aa 15-37 and 286-308 216595005442 Protein of unknown function (DUF3034); Region: DUF3034; pfam11231 216595005443 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is...; Region: Trunc_globin; cd00454 216595005444 apolar tunnel; other site 216595005445 heme binding site [chemical binding]; other site 216595005446 dimerization interface [polypeptide binding]; other site 216595005447 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595005449 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 216595005450 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 216595005451 Trp docking motif; other site 216595005452 active site 216595005453 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 216595005454 'Velcro' closure; other site 216595005461 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 216595005462 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216595005463 N-terminal plug; other site 216595005464 ligand-binding site [chemical binding]; other site 216595005467 Uncharacterized conserved protein (DUF2132); Region: DUF2132; cl01894 216595005468 6 probable transmembrane helices predicted for PFLU1088 by TMHMM2.0 at aa 5-23, 38-60, 72-94, 104-126, 139-157 and 177-199 216595005469 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 216595005470 FAD binding pocket [chemical binding]; other site 216595005471 FAD binding motif [chemical binding]; other site 216595005472 phosphate binding motif [ion binding]; other site 216595005473 NAD binding pocket [chemical binding]; other site 216595005476 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595005478 PFI-2 216595005479 putative fimbria biosynthesis-related CDS cluster 216595005480 Fimbrial protein; Region: Fimbrial; cl01416 216595005482 Fimbrial protein; Region: Fimbrial; cl01416 216595005484 pilin outer membrane usher protein SafC; Provisional; Region: PRK15223; cl14650 216595005485 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 216595005487 PS01151 Fimbrial biogenesis outer membrane usher protein signature. 216595005488 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 216595005489 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 216595005490 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 216595005492 PS00635 Gram-negative pili assembly chaperone signature. 216595005494 Fimbrial protein; Region: Fimbrial; cl01416 216595005496 Fimbrial protein; Region: Fimbrial; cl01416 216595005497 Fimbrial protein; Region: Fimbrial; cl01416 216595005498 Fimbrial protein; Region: Fimbrial; cl01416 216595005500 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 216595005501 Transglycosylase; Region: Transgly; cl07896 216595005502 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 216595005503 1 probable transmembrane helix predicted for PFLU1101 by TMHMM2.0 at aa 37-54 216595005504 PS00017 ATP/GTP-binding site motif A (P-loop). 216595005505 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 216595005507 12 probable transmembrane helices predicted for PFLU1103 by TMHMM2.0 at aa 41-60, 64-86, 119-141, 146-165, 177-199, 219-241, 262-284, 304-326, 357-375, 379-401, 422-444 and 449-471 216595005508 PS00218 Amino acid permeases signature. 216595005509 E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370 216595005510 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl15309 216595005511 Substrate binding site [chemical binding]; other site 216595005515 OpgC protein; Region: OpgC_C; cl10497 216595005516 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 216595005517 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 216595005518 active site 216595005519 FMN binding site [chemical binding]; other site 216595005520 substrate binding site [chemical binding]; other site 216595005521 3Fe-4S cluster binding site [ion binding]; other site 216595005523 1 probable transmembrane helix predicted for PFLU1107 by TMHMM2.0 at aa 5-27 216595005524 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 216595005526 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 216595005528 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 216595005530 Response regulator receiver domain; Region: Response_reg; pfam00072 216595005531 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595005532 active site 216595005533 phosphorylation site [posttranslational modification] 216595005534 intermolecular recognition site; other site 216595005535 dimerization interface [polypeptide binding]; other site 216595005536 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 216595005537 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595005538 ATP binding site [chemical binding]; other site 216595005539 Mg2+ binding site [ion binding]; other site 216595005540 G-X-G motif; other site 216595005544 two-component VirA-like sensor kinase; Provisional; Region: PRK13837 216595005545 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 216595005546 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595005547 ATP binding site [chemical binding]; other site 216595005548 Mg2+ binding site [ion binding]; other site 216595005549 G-X-G motif; other site 216595005551 Cytochrome c; Region: Cytochrom_C; cl11414 216595005552 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 216595005553 PS00190 Cytochrome c family heme-binding site signature. 216595005554 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 216595005556 PS00190 Cytochrome c family heme-binding site signature. 216595005557 Response regulator receiver domain; Region: Response_reg; pfam00072 216595005558 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595005559 active site 216595005560 phosphorylation site [posttranslational modification] 216595005561 intermolecular recognition site; other site 216595005562 dimerization interface [polypeptide binding]; other site 216595005563 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216595005564 metal binding site [ion binding]; metal-binding site 216595005565 active site 216595005566 I-site; other site 216595005567 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216595005569 PS00017 ATP/GTP-binding site motif A (P-loop). 216595005572 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 216595005573 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595005574 active site 216595005575 phosphorylation site [posttranslational modification] 216595005576 intermolecular recognition site; other site 216595005577 dimerization interface [polypeptide binding]; other site 216595005579 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 216595005580 nudix motif; other site 216595005582 PS00893 mutT domain signature. 216595005583 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 216595005585 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 216595005586 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595005587 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 216595005588 putative dimerization interface [polypeptide binding]; other site 216595005591 PS00044 Bacterial regulatory proteins, lysR family signature. 216595005592 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 216595005593 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595005595 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 216595005596 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 216595005597 catalytic residues [active] 216595005599 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 216595005600 4 probable transmembrane helices predicted for PFLU1123 by TMHMM2.0 at aa 5-27, 39-61, 76-98 and 105-124 216595005601 4 probable transmembrane helices predicted for PFLU1124 by TMHMM2.0 at aa 13-35, 55-77, 84-106 and 110-129 216595005603 Fatty acid desaturase; Region: FA_desaturase; pfam00487 216595005604 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 216595005605 putative di-iron ligands [ion binding]; other site 216595005607 MltA-interacting protein MipA; Region: MipA; cl01504 216595005609 1 probable transmembrane helix predicted for PFLU1126 by TMHMM2.0 at aa 13-32 216595005610 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 216595005611 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 216595005612 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 216595005613 4-aminobutyrate aminotransferase; Provisional; Region: PRK08360 216595005614 inhibitor-cofactor binding pocket; inhibition site 216595005615 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595005616 catalytic residue [active] 216595005618 PS01159 WW/rsp5/WWP domain signature. 216595005619 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 216595005620 Esterase/lipase [General function prediction only]; Region: COG1647 216595005621 FemAB family; Region: FemAB; cl11444 216595005622 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 216595005623 dimerization interface [polypeptide binding]; other site 216595005624 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595005625 dimer interface [polypeptide binding]; other site 216595005626 phosphorylation site [posttranslational modification] 216595005627 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595005628 ATP binding site [chemical binding]; other site 216595005629 Mg2+ binding site [ion binding]; other site 216595005630 G-X-G motif; other site 216595005631 1 probable transmembrane helix predicted for PFLU1131 by TMHMM2.0 at aa 24-46 216595005635 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 216595005636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595005637 active site 216595005638 phosphorylation site [posttranslational modification] 216595005639 intermolecular recognition site; other site 216595005640 dimerization interface [polypeptide binding]; other site 216595005641 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595005642 Walker A motif; other site 216595005643 ATP binding site [chemical binding]; other site 216595005644 Walker B motif; other site 216595005645 arginine finger; other site 216595005646 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 216595005649 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 216595005650 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 216595005651 PS00688 Sigma-54 interaction domain C-terminal part signature. 216595005653 GlpM protein; Region: GlpM; cl01212 216595005655 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 216595005656 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595005657 active site 216595005658 phosphorylation site [posttranslational modification] 216595005659 intermolecular recognition site; other site 216595005660 dimerization interface [polypeptide binding]; other site 216595005661 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595005662 Walker A motif; other site 216595005663 ATP binding site [chemical binding]; other site 216595005664 Walker B motif; other site 216595005665 arginine finger; other site 216595005666 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 216595005668 PS00688 Sigma-54 interaction domain C-terminal part signature. 216595005670 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 216595005671 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 216595005673 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 216595005674 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 216595005675 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595005676 ATP binding site [chemical binding]; other site 216595005677 Mg2+ binding site [ion binding]; other site 216595005678 G-X-G motif; other site 216595005681 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 216595005682 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 216595005683 Walker A/P-loop; other site 216595005684 ATP binding site [chemical binding]; other site 216595005685 Q-loop/lid; other site 216595005686 ABC transporter signature motif; other site 216595005687 Walker B; other site 216595005688 D-loop; other site 216595005689 H-loop/switch region; other site 216595005691 PS00211 ABC transporters family signature. 216595005692 PS00017 ATP/GTP-binding site motif A (P-loop). 216595005693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 216595005694 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216595005696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595005697 dimer interface [polypeptide binding]; other site 216595005698 conserved gate region; other site 216595005699 putative PBP binding loops; other site 216595005700 ABC-ATPase subunit interface; other site 216595005702 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 216595005703 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595005704 substrate binding pocket [chemical binding]; other site 216595005705 membrane-bound complex binding site; other site 216595005706 hinge residues; other site 216595005708 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 216595005709 PS00978 FAD-dependent glycerol-3-phosphate dehydrogenase signature 2. 216595005711 PS00977 FAD-dependent glycerol-3-phosphate dehydrogenase signature 1. 216595005712 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 216595005713 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595005714 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 216595005717 PS00894 Bacterial regulatory proteins, deoR family signature. 216595005718 glycerol kinase; Provisional; Region: glpK; PRK00047 216595005719 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 216595005720 N- and C-terminal domain interface [polypeptide binding]; other site 216595005721 active site 216595005722 MgATP binding site [chemical binding]; other site 216595005723 catalytic site [active] 216595005724 metal binding site [ion binding]; metal-binding site 216595005725 glycerol binding site [chemical binding]; other site 216595005726 homotetramer interface [polypeptide binding]; other site 216595005727 homodimer interface [polypeptide binding]; other site 216595005728 protein IIAGlc interface [polypeptide binding]; other site 216595005730 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595005731 PS00445 FGGY family of carbohydrate kinases signature 2. 216595005732 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595005734 PS00933 FGGY family of carbohydrate kinases signature 1. 216595005735 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cd00333 216595005736 amphipathic channel; other site 216595005737 Asn-Pro-Ala signature motifs; other site 216595005739 PS00221 MIP family signature. 216595005740 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS); Region: YbaK_deacylase; cd00002 216595005741 putative deacylase active site [active] 216595005743 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 216595005744 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 216595005745 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 216595005746 Walker A/P-loop; other site 216595005747 ATP binding site [chemical binding]; other site 216595005748 Q-loop/lid; other site 216595005749 ABC transporter signature motif; other site 216595005750 Walker B; other site 216595005751 D-loop; other site 216595005752 H-loop/switch region; other site 216595005753 TOBE domain; Region: TOBE_2; cl01440 216595005756 PS00211 ABC transporters family signature. 216595005757 PS00017 ATP/GTP-binding site motif A (P-loop). 216595005758 ornithine carbamoyltransferase; Provisional; Region: PRK00779 216595005759 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 216595005760 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595005763 PS00097 Aspartate and ornithine carbamoyltransferases signature. 216595005764 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 216595005765 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 216595005766 putative [Fe4-S4] binding site [ion binding]; other site 216595005767 putative molybdopterin cofactor binding site [chemical binding]; other site 216595005768 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 216595005769 putative molybdopterin cofactor binding site; other site 216595005774 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 216595005775 putative GSH binding site [chemical binding]; other site 216595005776 catalytic residues [active] 216595005778 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 216595005779 Ferritin-like domain; Region: Ferritin; pfam00210 216595005780 heme binding site [chemical binding]; other site 216595005781 ferroxidase pore; other site 216595005782 ferroxidase diiron center [ion binding]; other site 216595005784 PS00549 Bacterioferritin signature. 216595005785 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 216595005787 peroxidase; Provisional; Region: PRK15000 216595005788 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic...; Region: PRX_Typ2cys; cd03015 216595005789 dimer interface [polypeptide binding]; other site 216595005790 decamer (pentamer of dimers) interface [polypeptide binding]; other site 216595005791 catalytic triad [active] 216595005792 peroxidatic and resolving cysteines [active] 216595005795 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 216595005796 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 216595005797 dimer interface [polypeptide binding]; other site 216595005798 putative active site [active] 216595005799 putative substrate binding site [chemical binding]; other site 216595005800 catalytic site [active] 216595005802 Dihydroorotase [Nucleotide transport and metabolism]; Region: PyrC; COG0418 216595005803 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 216595005804 active site 216595005805 substrate binding pocket [chemical binding]; other site 216595005806 dimer interface [polypeptide binding]; other site 216595005808 PS00483 Dihydroorotase signature 2. 216595005809 PS00482 Dihydroorotase signature 1. 216595005810 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216595005811 ligand binding site [chemical binding]; other site 216595005813 argininosuccinate synthase; Provisional; Region: PLN00200 216595005814 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 216595005815 ANP binding site [chemical binding]; other site 216595005816 Substrate Binding Site II [chemical binding]; other site 216595005817 Substrate Binding Site I [chemical binding]; other site 216595005819 PS00564 Argininosuccinate synthase signature 1. 216595005820 PS00565 Argininosuccinate synthase signature 2. 216595005821 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216595005822 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595005823 active site 216595005824 phosphorylation site [posttranslational modification] 216595005825 intermolecular recognition site; other site 216595005826 dimerization interface [polypeptide binding]; other site 216595005827 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 216595005828 DNA binding residues [nucleotide binding] 216595005829 dimerization interface [polypeptide binding]; other site 216595005832 PS00622 Bacterial regulatory proteins, luxR family signature. 216595005833 endonuclease III; Provisional; Region: PRK10702 216595005834 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 216595005835 minor groove reading motif; other site 216595005836 helix-hairpin-helix signature motif; other site 216595005837 substrate binding pocket [chemical binding]; other site 216595005838 active site 216595005839 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 216595005840 PS00764 Endonuclease III iron-sulfur binding region signature. 216595005843 electron transport complex protein RnfB; Provisional; Region: PRK05113 216595005844 Putative Fe-S cluster; Region: FeS; pfam04060 216595005845 4Fe-4S binding domain; Region: Fer4; cl02805 216595005847 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216595005849 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216595005851 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 216595005852 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 216595005853 active site 216595005854 HIGH motif; other site 216595005855 KMSKS motif; other site 216595005856 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 216595005857 tRNA binding surface [nucleotide binding]; other site 216595005858 anticodon binding site; other site 216595005859 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 216595005860 dimer interface [polypeptide binding]; other site 216595005861 putative tRNA-binding site [nucleotide binding]; other site 216595005864 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 216595005865 antiporter inner membrane protein; Provisional; Region: PRK11670 216595005866 Domain of unknown function DUF59; Region: DUF59; cl00941 216595005867 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 216595005869 PS01118 Translation initiation factor SUI1 signature. 216595005870 PS00017 ATP/GTP-binding site motif A (P-loop). 216595005871 PS01215 Mrp family signature. 216595005872 Ferredoxin [Energy production and conversion]; Region: COG1146 216595005873 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 216595005875 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216595005877 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 216595005878 MutS domain I; Region: MutS_I; pfam01624 216595005879 MutS domain II; Region: MutS_II; pfam05188 216595005880 MutS family domain IV; Region: MutS_IV; pfam05190 216595005881 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 216595005882 Walker A/P-loop; other site 216595005883 ATP binding site [chemical binding]; other site 216595005884 Q-loop/lid; other site 216595005885 ABC transporter signature motif; other site 216595005886 Walker B; other site 216595005887 D-loop; other site 216595005888 H-loop/switch region; other site 216595005890 PS00486 DNA mismatch repair proteins mutS family signature. 216595005891 PS00017 ATP/GTP-binding site motif A (P-loop). 216595005895 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595005897 Uncharacterized phage-associated protein [Function unknown]; Region: GepA; COG3600 216595005898 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216595005899 non-specific DNA binding site [nucleotide binding]; other site 216595005900 salt bridge; other site 216595005901 sequence-specific DNA binding site [nucleotide binding]; other site 216595005902 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 216595005903 Catalytic site [active] 216595005906 Prophage 1 216595005907 3 probable transmembrane helices predicted for PFLU1169 by TMHMM2.0 at aa 10-32, 45-67 and 71-93 216595005908 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595005909 Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432 216595005911 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 216595005912 Baseplate J-like protein; Region: Baseplate_J; cl01294 216595005914 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 216595005915 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 216595005916 Phage Tail Collar Domain; Region: Collar; pfam07484 216595005917 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 216595005918 Phage Tail Collar Domain; Region: Collar; pfam07484 216595005921 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 216595005922 Phage tail tube protein FII; Region: Phage_tube; cl01390 216595005923 PS00017 ATP/GTP-binding site motif A (P-loop). 216595005924 Phage P2 GpU; Region: Phage_P2_GpU; cl01391 216595005926 Phage Tail Protein X; Region: Phage_tail_X; cl02088 216595005928 Phage protein D [General function prediction only]; Region: COG3500; cl12180 216595005929 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 216595005931 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 216595005932 catalytic residue [active] 216595005934 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 216595005935 Competence-damaged protein; Region: CinA; cl00666 216595005937 recombinase A; Provisional; Region: recA; PRK09354 216595005938 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 216595005939 hexamer interface [polypeptide binding]; other site 216595005940 Walker A motif; other site 216595005941 ATP binding site [chemical binding]; other site 216595005942 Walker B motif; other site 216595005944 PS00017 ATP/GTP-binding site motif A (P-loop). 216595005945 PS00321 recA signature. 216595005946 RecX family; Region: RecX; cl00936 216595005948 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 216595005950 DTW domain; Region: DTW; cl01221 216595005952 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216595005953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595005954 active site 216595005955 phosphorylation site [posttranslational modification] 216595005956 intermolecular recognition site; other site 216595005957 dimerization interface [polypeptide binding]; other site 216595005958 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 216595005959 DNA binding residues [nucleotide binding] 216595005960 dimerization interface [polypeptide binding]; other site 216595005963 PS00622 Bacterial regulatory proteins, luxR family signature. 216595005964 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 216595005966 3 probable transmembrane helices predicted for PFLU1196 by TMHMM2.0 at aa 36-57, 64-86 and 106-123 216595005967 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 216595005968 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595005969 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 216595005970 putative dimerization interface [polypeptide binding]; other site 216595005973 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 216595005974 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 216595005975 FAD binding pocket [chemical binding]; other site 216595005976 FAD binding motif [chemical binding]; other site 216595005977 phosphate binding motif [ion binding]; other site 216595005978 beta-alpha-beta structure motif; other site 216595005979 NAD binding pocket [chemical binding]; other site 216595005982 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 216595005983 homodimer interaction site [polypeptide binding]; other site 216595005984 cofactor binding site; other site 216595005986 PS01318 Uncharacterized protein family UPF0066 signature. 216595005987 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 216595005988 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 216595005989 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 216595005992 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 216595005993 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 216595005994 PSSA_1: Pseudouridine synthase, a subgroup of the RsuA family. This group is comprised of bacterial proteins assigned to the RsuA family of pseudouridine synthases. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PSSA_1; cd02555 216595005995 active site 216595005997 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216595005998 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 216595005999 Coenzyme A binding pocket [chemical binding]; other site 216595006001 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 216595006002 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 216595006003 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 216595006004 FeS/SAM binding site; other site 216595006006 PS01278 Uncharacterized protein family UPF0004 signature. 216595006008 K+ potassium transporter; Region: K_trans; cl01227 216595006009 potassium uptake protein; Region: kup; TIGR00794 216595006010 12 probable transmembrane helices predicted for PFLU1204 by TMHMM2.0 at aa 20-42, 57-76, 113-135, 150-169, 181-203, 223-245, 258-280, 295-317, 349-368, 378-400, 407-426 and 431-448 216595006012 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 216595006013 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 216595006014 active site 216595006015 FMN binding site [chemical binding]; other site 216595006016 substrate binding site [chemical binding]; other site 216595006017 homotetramer interface [polypeptide binding]; other site 216595006018 catalytic residue [active] 216595006020 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl01208 216595006022 1 probable transmembrane helix predicted for PFLU1207 by TMHMM2.0 at aa 12-31 216595006024 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216595006025 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 216595006026 tetrameric interface [polypeptide binding]; other site 216595006027 NAD binding site [chemical binding]; other site 216595006028 catalytic residues [active] 216595006029 substrate binding site [chemical binding]; other site 216595006031 PS00687 Aldehyde dehydrogenases glutamic acid active site. 216595006032 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 216595006033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595006034 dimer interface [polypeptide binding]; other site 216595006035 conserved gate region; other site 216595006036 putative PBP binding loops; other site 216595006037 ABC-ATPase subunit interface; other site 216595006039 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595006040 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 216595006041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595006042 dimer interface [polypeptide binding]; other site 216595006043 putative PBP binding loops; other site 216595006044 ABC-ATPase subunit interface; other site 216595006046 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595006047 PS00017 ATP/GTP-binding site motif A (P-loop). 216595006048 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 216595006049 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595006050 Walker A/P-loop; other site 216595006051 ATP binding site [chemical binding]; other site 216595006052 Q-loop/lid; other site 216595006053 ABC transporter signature motif; other site 216595006054 Walker B; other site 216595006055 D-loop; other site 216595006056 H-loop/switch region; other site 216595006057 TOBE domain; Region: TOBE_2; cl01440 216595006060 PS00211 ABC transporters family signature. 216595006061 PS00017 ATP/GTP-binding site motif A (P-loop). 216595006062 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595006064 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216595006065 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 216595006066 tetrameric interface [polypeptide binding]; other site 216595006067 NAD binding site [chemical binding]; other site 216595006068 catalytic residues [active] 216595006069 substrate binding site [chemical binding]; other site 216595006071 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595006072 PS00687 Aldehyde dehydrogenases glutamic acid active site. 216595006073 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595006074 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595006075 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 216595006076 putative substrate binding pocket [chemical binding]; other site 216595006077 dimerization interface [polypeptide binding]; other site 216595006080 PS00044 Bacterial regulatory proteins, lysR family signature. 216595006081 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 216595006082 putative metal binding site [ion binding]; other site 216595006083 2 probable transmembrane helices predicted for PFLU1216 by TMHMM2.0 at aa 43-65 and 85-102 216595006085 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 216595006086 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 216595006088 PS00041 Bacterial regulatory proteins, araC family signature. 216595006089 wsp operon EMBL:AY074937 216595006090 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 216595006091 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595006092 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595006093 2 probable transmembrane helices predicted for PFLU1219 by TMHMM2.0 at aa 10-29 and 192-214 216595006096 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 216595006098 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 216595006099 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 216595006100 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 216595006101 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 216595006102 binding surface 216595006103 TPR motif; other site 216595006106 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 216595006108 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 216595006109 putative binding surface; other site 216595006110 active site 216595006111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595006112 ATP binding site [chemical binding]; other site 216595006113 Mg2+ binding site [ion binding]; other site 216595006114 G-X-G motif; other site 216595006115 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 216595006116 Response regulator receiver domain; Region: Response_reg; pfam00072 216595006117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595006118 active site 216595006119 phosphorylation site [posttranslational modification] 216595006120 intermolecular recognition site; other site 216595006121 dimerization interface [polypeptide binding]; other site 216595006126 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 216595006127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595006128 active site 216595006129 phosphorylation site [posttranslational modification] 216595006130 intermolecular recognition site; other site 216595006131 dimerization interface [polypeptide binding]; other site 216595006132 CheB methylesterase; Region: CheB_methylest; pfam01339 216595006135 Response regulator receiver domain; Region: Response_reg; pfam00072 216595006136 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595006137 active site 216595006138 phosphorylation site [posttranslational modification] 216595006139 intermolecular recognition site; other site 216595006140 dimerization interface [polypeptide binding]; other site 216595006141 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216595006142 metal binding site [ion binding]; metal-binding site 216595006143 active site 216595006144 I-site; other site 216595006149 PS00745 Prokaryotic-type class I peptide chain release factors signature. 216595006150 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595006151 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 216595006152 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 216595006153 dimer interface [polypeptide binding]; other site 216595006154 putative anticodon binding site; other site 216595006155 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 216595006156 motif 1; other site 216595006157 active site 216595006158 motif 2; other site 216595006159 motif 3; other site 216595006162 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 216595006163 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216595006164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 216595006166 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595006167 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 216595006168 conserved hypothetical protein; Region: QEGLA; TIGR02421 216595006170 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595006171 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216595006172 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595006173 1 probable transmembrane helix predicted for PFLU1232 by TMHMM2.0 at aa 12-31 216595006175 1 probable transmembrane helix predicted for PFLU1233 by TMHMM2.0 at aa 7-29 216595006176 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595006177 1 probable transmembrane helix predicted for PFLU1234 by TMHMM2.0 at aa 13-35 216595006178 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 216595006179 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216595006180 ligand binding site [chemical binding]; other site 216595006182 PS01068 OmpA-like domain. 216595006183 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595006184 Phosphoenolpyruvate carboxylase [Carbohydrate transport and metabolism; Energy production and conversion]; Region: COG1892; cl14656 216595006185 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 216595006187 PS00781 Phosphoenolpyruvate carboxylase active site 1. 216595006188 PS00393 Phosphoenolpyruvate carboxylase active site 2. 216595006189 adenylate kinase; Reviewed; Region: adk; PRK00279 216595006190 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 216595006191 AMP-binding site [chemical binding]; other site 216595006192 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 216595006194 PS00113 Adenylate kinase signature. 216595006196 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 216595006198 Protein of unknown function DUF72; Region: DUF72; cl00777 216595006200 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 216595006201 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 216595006202 tetramer interface [polypeptide binding]; other site 216595006203 active site 216595006204 Mg2+/Mn2+ binding site [ion binding]; other site 216595006205 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 216595006206 2 probable transmembrane helices predicted for PFLU1246 by TMHMM2.0 at aa 7-26 and 95-117 216595006207 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595006209 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 216595006211 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216595006212 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216595006214 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 216595006215 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595006217 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 216595006219 12 probable transmembrane helices predicted for PFLU1251 by TMHMM2.0 at aa 13-32, 336-355, 362-384, 388-407, 427-449, 464-486, 532-551, 865-882, 889-908, 912-934, 961-978 and 988-1010 216595006220 PS00589 PTS HPR component serine phosphorylation site signature. 216595006221 1 probable transmembrane helix predicted for PFLU1252 by TMHMM2.0 at aa 107-129 216595006222 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 216595006223 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595006224 Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937 216595006225 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 216595006226 putative acyl-acceptor binding pocket; other site 216595006228 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 216595006229 DNA-binding site [nucleotide binding]; DNA binding site 216595006230 RNA-binding motif; other site 216595006232 PS00352 'Cold-shock' DNA-binding domain signature. 216595006233 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 216595006234 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 216595006236 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 216595006237 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 216595006238 metal binding site [ion binding]; metal-binding site 216595006239 dimer interface [polypeptide binding]; other site 216595006242 Glycosyl hydrolases family 17; Region: Glyco_hydro_17; cl02191 216595006243 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 216595006244 NdvC_like proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase; Region: CESA_NdvC_like; cd06435 216595006245 Ligand binding site [chemical binding]; other site 216595006246 DXD motif; other site 216595006249 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 216595006250 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-...; Region: YgdL_like; cd00755 216595006251 putative ATP binding site [chemical binding]; other site 216595006252 putative substrate interface [chemical binding]; other site 216595006254 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 216595006255 Fe-S metabolism associated domain; Region: SufE; cl00951 216595006257 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 216595006258 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 216595006259 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216595006260 catalytic residue [active] 216595006262 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 216595006263 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536 216595006264 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 216595006265 putative trimer interface [polypeptide binding]; other site 216595006266 putative CoA binding site [chemical binding]; other site 216595006267 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 216595006268 putative catalytic residues [active] 216595006270 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 216595006271 10 probable transmembrane helices predicted for PFLU1266 by TMHMM2.0 at aa 21-43, 58-80, 101-123, 128-150, 171-190, 194-216, 285-307, 331-353, 374-396 and 411-433 216595006273 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595006274 hypothetical protein; Validated; Region: PRK07682 216595006275 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216595006276 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595006277 homodimer interface [polypeptide binding]; other site 216595006278 catalytic residue [active] 216595006280 PS00215 Mitochondrial energy transfer proteins signature. 216595006281 PS00215 Mitochondrial energy transfer proteins signature. 216595006282 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 216595006283 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 216595006284 metal binding triad; other site 216595006285 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 216595006286 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 216595006287 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 216595006288 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 216595006294 methionine aminopeptidase; Reviewed; Region: PRK07281 216595006295 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 216595006296 active site 216595006298 PS00680 Methionine aminopeptidase subfamily 1 signature. 216595006299 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 216595006300 rRNA interaction site [nucleotide binding]; other site 216595006301 S8 interaction site; other site 216595006302 putative laminin-1 binding site; other site 216595006303 PS00962 Ribosomal protein S2 signature 1. 216595006305 PS00963 Ribosomal protein S2 signature 2. 216595006306 elongation factor Ts; Provisional; Region: tsf; PRK09377 216595006307 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 216595006308 Elongation factor TS; Region: EF_TS; pfam00889 216595006309 Elongation factor TS; Region: EF_TS; pfam00889 216595006311 PS01126 Elongation factor Ts signature 1. 216595006313 PS00017 ATP/GTP-binding site motif A (P-loop). 216595006314 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 216595006315 putative nucleotide binding site [chemical binding]; other site 216595006316 uridine monophosphate binding site [chemical binding]; other site 216595006317 homohexameric interface [polypeptide binding]; other site 216595006319 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 216595006320 hinge region; other site 216595006322 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 216595006323 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 216595006324 catalytic residue [active] 216595006325 putative FPP diphosphate binding site; other site 216595006326 putative FPP binding hydrophobic cleft; other site 216595006327 dimer interface [polypeptide binding]; other site 216595006328 putative IPP diphosphate binding site; other site 216595006330 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 216595006332 8 probable transmembrane helices predicted for PFLU1275 by TMHMM2.0 at aa 5-23, 27-49, 56-73, 78-97, 104-126, 136-155, 176-198 and 202-219 216595006333 ggaaccnnnnnnnnnnnnnnnnccacnna 216595006334 PS01315 Phosphatidate cytidylyltransferase signature. 216595006335 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 216595006336 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 216595006337 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 216595006340 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 216595006341 zinc metallopeptidase RseP; Provisional; Region: PRK10779 216595006342 active site 216595006343 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 216595006344 protein binding site [polypeptide binding]; other site 216595006345 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 216595006346 protein binding site [polypeptide binding]; other site 216595006347 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 216595006348 putative substrate binding region [chemical binding]; other site 216595006349 4 probable transmembrane helices predicted for PFLU1277 by TMHMM2.0 at aa 7-29, 97-119, 379-401 and 425-444 216595006351 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 216595006353 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 216595006354 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 216595006355 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 216595006356 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 216595006357 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 216595006358 Surface antigen; Region: Bac_surface_Ag; cl03097 216595006365 periplasmic chaperone; Provisional; Region: PRK10780 216595006366 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 216595006368 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 216595006369 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 216595006370 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2,3-...; Region: LbH_LpxD; cd03352 216595006371 trimer interface [polypeptide binding]; other site 216595006372 active site 216595006373 UDP-GlcNAc binding site [chemical binding]; other site 216595006374 lipid binding site [chemical binding]; lipid-binding site 216595006377 PS00101 Hexapeptide-repeat containing-transferases signature. 216595006385 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 216595006387 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 216595006388 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A...; Region: LbH_UDP-GlcNAc_AT; cd03351 216595006389 active site 216595006390 PS00101 Hexapeptide-repeat containing-transferases signature. 216595006398 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 216595006399 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 216595006401 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 216595006402 RNA/DNA hybrid binding site [nucleotide binding]; other site 216595006403 active site 216595006405 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 216595006406 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 216595006407 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 216595006408 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 216595006409 generic binding surface II; other site 216595006410 generic binding surface I; other site 216595006414 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 216595006416 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 216595006417 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 216595006418 Ligand Binding Site [chemical binding]; other site 216595006419 TilS substrate binding domain; Region: TilS; pfam09179 216595006420 B3/4 domain; Region: B3_4; cl11458 216595006423 CTP synthetase; Validated; Region: pyrG; PRK05380 216595006424 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 216595006425 Catalytic site [active] 216595006426 Active site [active] 216595006427 UTP binding site [chemical binding]; other site 216595006428 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 216595006429 active site 216595006430 putative oxyanion hole; other site 216595006431 catalytic triad [active] 216595006433 1 probable transmembrane helix predicted for PFLU1289 by TMHMM2.0 at aa 5-27 216595006435 PS00442 Glutamine amidotransferases class-I active site. 216595006436 NeuB family; Region: NeuB; cl00496 216595006437 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 216595006439 enolase; Provisional; Region: eno; PRK00077 216595006440 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 216595006441 dimer interface [polypeptide binding]; other site 216595006442 metal binding site [ion binding]; metal-binding site 216595006443 substrate binding pocket [chemical binding]; other site 216595006446 PS00164 Enolase signature. 216595006447 Septum formation initiator; Region: DivIC; cl11433 216595006448 1 probable transmembrane helix predicted for PFLU1292 by TMHMM2.0 at aa 27-46 216595006450 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 216595006451 substrate binding site [chemical binding]; other site 216595006452 dimer interface [polypeptide binding]; other site 216595006454 PS01295 Uncharacterized protein family UPF0007 signature. 216595006455 LysR family transcriptional regulator; Provisional; Region: PRK14997 216595006456 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595006457 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like_1; cd08470 216595006458 putative effector binding pocket; other site 216595006459 putative dimerization interface [polypeptide binding]; other site 216595006462 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 216595006463 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 216595006464 substrate binding site [chemical binding]; other site 216595006465 catalytic Zn binding site [ion binding]; other site 216595006466 NAD binding site [chemical binding]; other site 216595006467 structural Zn binding site [ion binding]; other site 216595006468 dimer interface [polypeptide binding]; other site 216595006471 Predicted esterase [General function prediction only]; Region: COG0627 216595006472 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595006474 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cd00554 216595006475 homotrimer interaction site [polypeptide binding]; other site 216595006476 zinc binding site [ion binding]; other site 216595006477 CDP-binding sites; other site 216595006479 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 216595006480 PseudoU_synth_EcTruD: Pseudouridine synthase, TruD family. This group consists of bacterial pseudouridine synthases similar to Escherichia coli TruD. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_EcTruD; cd02575 216595006481 Permutation of conserved domain; other site 216595006482 active site 216595006483 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 216595006485 PS01268 Uncharacterized protein family UPF0024 signature. 216595006486 Survival protein SurE; Region: SurE; cl00448 216595006488 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 216595006489 S-adenosylmethionine binding site [chemical binding]; other site 216595006491 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216595006492 PS01279 Protein-L-isoaspartate(D-aspartate) O-methyltransferase signature. 216595006493 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 216595006494 putative peptidoglycan binding site; other site 216595006495 Peptidase family M23; Region: Peptidase_M23; pfam01551 216595006496 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595006499 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 216595006500 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 216595006501 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216595006502 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 216595006503 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 216595006506 PS00715 Sigma-70 factors family signature 1. 216595006509 PS00716 Sigma-70 factors family signature 2. 216595006510 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 216595006511 DNA-binding site [nucleotide binding]; DNA binding site 216595006512 RNA-binding motif; other site 216595006514 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 216595006515 trimer interface [polypeptide binding]; other site 216595006516 active site 216595006518 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 216595006519 putative active site [active] 216595006520 putative metal binding site [ion binding]; other site 216595006522 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 216595006523 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216595006524 ATP binding site [chemical binding]; other site 216595006525 putative Mg++ binding site [ion binding]; other site 216595006526 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216595006527 nucleotide binding region [chemical binding]; other site 216595006528 ATP-binding site [chemical binding]; other site 216595006529 DEAD/H associated; Region: DEAD_assoc; pfam08494 216595006533 PS00017 ATP/GTP-binding site motif A (P-loop). 216595006534 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 216595006535 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 216595006536 Walker A/P-loop; other site 216595006537 ATP binding site [chemical binding]; other site 216595006538 Q-loop/lid; other site 216595006539 ABC transporter signature motif; other site 216595006540 Walker B; other site 216595006541 D-loop; other site 216595006542 H-loop/switch region; other site 216595006544 PS00211 ABC transporters family signature. 216595006545 PS00017 ATP/GTP-binding site motif A (P-loop). 216595006546 An uncharacterized subgroup of the Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) subfamily which is part of the the M14 family of metallocarboxypeptidases. This subgroup includes Pseudomonas aeruginosa AotO and related proteins. ASTE...; Region: M14_PaAOTO_like; cd06250 216595006547 putative active site [active] 216595006548 Zn-binding site [ion binding]; other site 216595006550 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595006551 dimer interface [polypeptide binding]; other site 216595006552 conserved gate region; other site 216595006553 putative PBP binding loops; other site 216595006554 ABC-ATPase subunit interface; other site 216595006556 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595006557 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216595006558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595006559 dimer interface [polypeptide binding]; other site 216595006560 conserved gate region; other site 216595006561 putative PBP binding loops; other site 216595006562 ABC-ATPase subunit interface; other site 216595006564 PS00017 ATP/GTP-binding site motif A (P-loop). 216595006565 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595006566 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 216595006567 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595006568 substrate binding pocket [chemical binding]; other site 216595006569 membrane-bound complex binding site; other site 216595006570 hinge residues; other site 216595006572 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 216595006573 1 probable transmembrane helix predicted for PFLU1311 by TMHMM2.0 at aa 12-29 216595006574 ATP-dependent DNA ligase; Validated; Region: PRK09247 216595006575 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 216595006576 active site 216595006577 DNA binding site [nucleotide binding] 216595006578 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 216595006579 DNA binding site [nucleotide binding] 216595006582 PS00697 ATP-dependent DNA ligase AMP-binding site. 216595006583 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 216595006584 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 216595006585 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 216595006586 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 216595006587 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and 7-...; Region: Ntn_PGA_like; cd03747 216595006588 active site 216595006590 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595006591 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 216595006592 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_N_Ure2p_like; cd03048 216595006593 C-terminal domain interface [polypeptide binding]; other site 216595006594 GSH binding site (G-site) [chemical binding]; other site 216595006595 dimer interface [polypeptide binding]; other site 216595006596 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 216595006597 N-terminal domain interface [polypeptide binding]; other site 216595006598 putative dimer interface [polypeptide binding]; other site 216595006599 active site 216595006602 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12900 216595006603 SEC-C motif; Region: SEC-C; cl12132 216595006605 LEA14-like dessication related protein [Defense mechanisms]; Region: COG5608 216595006606 Late embryogenesis abundant protein; Region: LEA_2; cl12118 216595006607 1 probable transmembrane helix predicted for PFLU1318 by TMHMM2.0 at aa 21-43 216595006608 hypothetical protein; Provisional; Region: PRK00183 216595006609 SEC-C motif; Region: SEC-C; cl12132 216595006610 SEC-C motif; Region: SEC-C; cl12132 216595006612 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216595006613 ligand binding site [chemical binding]; other site 216595006614 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595006616 Copper resistance protein D; Region: CopD; cl00563 216595006617 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 216595006618 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595006619 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595006620 PS00017 ATP/GTP-binding site motif A (P-loop). 216595006621 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 216595006622 Beta-lactamase; Region: Beta-lactamase; cl01009 216595006624 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216595006625 ligand binding site [chemical binding]; other site 216595006627 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 216595006628 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 216595006629 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 216595006631 PS01064 Pyridoxamine 5'-phosphate oxidase signature. 216595006632 1 probable transmembrane helix predicted for PFLU1329 by TMHMM2.0 at aa 4-21 216595006633 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 216595006634 2 probable transmembrane helices predicted for PFLU1330 by TMHMM2.0 at aa 33-55 and 105-127 216595006635 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595006637 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 216595006639 PS00017 ATP/GTP-binding site motif A (P-loop). 216595006640 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 216595006641 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 216595006642 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216595006643 catalytic residue [active] 216595006645 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 216595006647 Predicted membrane protein [Function unknown]; Region: COG3650 216595006648 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595006649 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595006650 NAD(P) binding site [chemical binding]; other site 216595006651 active site 216595006653 transcriptional regulator; Provisional; Region: PRK10632 216595006654 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595006655 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 216595006656 putative effector binding pocket; other site 216595006657 dimerization interface [polypeptide binding]; other site 216595006660 DoxX; Region: DoxX; cl00976 216595006662 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 216595006663 hypothetical protein; Provisional; Region: PRK05409 216595006664 Protein of unknown function (DUF692); Region: DUF692; cl01263 216595006666 Predicted integral membrane protein (DUF2282); Region: DUF2282; cl02366 216595006667 1 probable transmembrane helix predicted for PFLU1341 by TMHMM2.0 at aa 20-42 216595006668 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 216595006669 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 216595006670 Walker A/P-loop; other site 216595006671 ATP binding site [chemical binding]; other site 216595006672 Q-loop/lid; other site 216595006673 ABC transporter signature motif; other site 216595006674 Walker B; other site 216595006675 D-loop; other site 216595006676 H-loop/switch region; other site 216595006678 PS00211 ABC transporters family signature. 216595006679 PS00017 ATP/GTP-binding site motif A (P-loop). 216595006680 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 216595006681 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 216595006682 Walker A/P-loop; other site 216595006683 ATP binding site [chemical binding]; other site 216595006684 Q-loop/lid; other site 216595006685 ABC transporter signature motif; other site 216595006686 Walker B; other site 216595006687 D-loop; other site 216595006688 H-loop/switch region; other site 216595006690 PS00211 ABC transporters family signature. 216595006691 PS00017 ATP/GTP-binding site motif A (P-loop). 216595006692 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 216595006693 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 216595006694 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 216595006695 TM-ABC transporter signature motif; other site 216595006697 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 216595006698 TM-ABC transporter signature motif; other site 216595006700 PS00044 Bacterial regulatory proteins, lysR family signature. 216595006701 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 216595006702 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 216595006703 dimerization interface [polypeptide binding]; other site 216595006704 ligand binding site [chemical binding]; other site 216595006706 Protein of unknown function (DUF2288); Region: DUF2288; cl02399 216595006707 PS00605 ATP synthase c subunit signature. 216595006708 PS00227 Tubulin subunits alpha, beta, and gamma signature. 216595006709 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 216595006710 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 216595006711 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 216595006712 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216595006713 metal binding site [ion binding]; metal-binding site 216595006714 active site 216595006715 I-site; other site 216595006716 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216595006722 Flagellin N-methylase; Region: FliB; cl00497 216595006724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595006725 putative substrate translocation pore; other site 216595006726 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216595006727 12 probable transmembrane helices predicted for PFLU1351 by TMHMM2.0 at aa 13-35, 48-70, 83-105, 109-131, 138-160, 170-187, 212-234, 254-276, 289-307, 317-339, 352-374 and 404-426 216595006730 ATP-dependent helicase HepA; Validated; Region: PRK04914 216595006731 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216595006732 ATP binding site [chemical binding]; other site 216595006733 putative Mg++ binding site [ion binding]; other site 216595006734 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216595006735 nucleotide binding region [chemical binding]; other site 216595006736 ATP-binding site [chemical binding]; other site 216595006739 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 216595006740 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 216595006741 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216595006742 catalytic residue [active] 216595006744 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 216595006745 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 216595006746 homotrimer interaction site [polypeptide binding]; other site 216595006747 putative active site [active] 216595006749 PS00044 Bacterial regulatory proteins, lysR family signature. 216595006750 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 216595006751 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595006752 HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 216595006753 dimerization interface [polypeptide binding]; other site 216595006754 substrate binding pocket [chemical binding]; other site 216595006757 PS00044 Bacterial regulatory proteins, lysR family signature. 216595006758 1 probable transmembrane helix predicted for PFLU1358 by TMHMM2.0 at aa 7-29 216595006759 Phosphate transporter family; Region: PHO4; cl00396 216595006760 Phosphate transporter family; Region: PHO4; cl00396 216595006762 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 216595006763 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595006764 Bacterial transcriptional regulator; Region: IclR; pfam01614 216595006767 PS01051 Bacterial regulatory proteins, iclR family signature. 216595006768 benzoate transport; Region: 2A0115; TIGR00895 216595006769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595006770 putative substrate translocation pore; other site 216595006771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595006772 12 probable transmembrane helices predicted for PFLU1362 by TMHMM2.0 at aa 54-76, 91-113, 120-142, 146-168, 175-197, 207-229, 292-314, 324-346, 358-380, 384-406, 419-441 and 446-468 216595006774 PS00216 Sugar transport proteins signature 1. 216595006775 PS00217 Sugar transport proteins signature 2. 216595006776 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 216595006778 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 216595006780 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 216595006781 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 216595006782 dimer interface [polypeptide binding]; other site 216595006783 active site 216595006785 PS00098 Thiolases acyl-enzyme intermediate signature. 216595006787 PS00737 Thiolases signature 2. 216595006788 PS00099 Thiolases active site. 216595006789 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 216595006790 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 216595006791 multimer interface [polypeptide binding]; other site 216595006792 heterodimer interface [polypeptide binding]; other site 216595006793 active site 216595006795 PS00083 Intradiol ring-cleavage dioxygenases signature. 216595006796 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 216595006797 heterodimer interface [polypeptide binding]; other site 216595006798 active site 216595006800 PS00083 Intradiol ring-cleavage dioxygenases signature. 216595006801 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 216595006802 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595006803 putative substrate translocation pore; other site 216595006805 12 probable transmembrane helices predicted for PFLU1368 by TMHMM2.0 at aa 21-43, 58-80, 93-112, 117-136, 156-178, 193-210, 241-263, 278-300, 307-324, 334-356, 369-391 and 401-418 216595006806 PS00217 Sugar transport proteins signature 2. 216595006807 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 216595006808 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 216595006809 tetramer interface [polypeptide binding]; other site 216595006810 active site 216595006812 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595006813 PS00163 Fumarate lyases signature. 216595006814 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 216595006816 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 216595006818 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 216595006820 1 probable transmembrane helix predicted for PFLU1372 by TMHMM2.0 at aa 26-45 216595006821 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595006822 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 216595006823 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 216595006827 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 216595006828 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 216595006832 outer membrane porin, OprD family; Region: OprD; pfam03573 216595006834 PS00309 Galaptin signature. 216595006835 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cl02542 216595006837 Hsp70 protein; Region: HSP70; pfam00012 216595006838 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 216595006840 PS01036 Heat shock hsp70 proteins family signature 3. 216595006841 PS00329 Heat shock hsp70 proteins family signature 2. 216595006842 PS00297 Heat shock hsp70 proteins family signature 1. 216595006843 NodT family; Region: outer_NodT; TIGR01845 216595006844 Outer membrane efflux protein; Region: OEP; pfam02321 216595006845 Outer membrane efflux protein; Region: OEP; pfam02321 216595006848 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595006849 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 216595006850 Protein export membrane protein; Region: SecD_SecF; cl14618 216595006852 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 216595006854 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595006855 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 216595006856 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216595006857 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 216595006859 PS01081 Bacterial regulatory proteins, tetR family signature. 216595006861 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595006863 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 216595006865 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 216595006866 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 216595006867 chorismate binding enzyme; Region: Chorismate_bind; cl10555 216595006870 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 216595006871 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 216595006872 glutamine binding [chemical binding]; other site 216595006873 catalytic triad [active] 216595006875 PS00442 Glutamine amidotransferases class-I active site. 216595006876 PS00572 Glycosyl hydrolases family 1 active site. 216595006877 Autoinducer binding domain; Region: Autoind_bind; pfam03472 216595006878 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 216595006879 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 216595006880 DNA binding residues [nucleotide binding] 216595006881 dimerization interface [polypeptide binding]; other site 216595006884 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 216595006885 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 216595006886 FMN binding site [chemical binding]; other site 216595006887 active site 216595006888 substrate binding site [chemical binding]; other site 216595006889 catalytic residue [active] 216595006891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595006892 putative substrate translocation pore; other site 216595006893 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216595006895 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216595006896 dimerization interface [polypeptide binding]; other site 216595006897 putative DNA binding site [nucleotide binding]; other site 216595006898 putative Zn2+ binding site [ion binding]; other site 216595006900 Protein of unknown function, DUF479; Region: DUF479; cl01203 216595006902 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 216595006903 putative acyl-acceptor binding pocket; other site 216595006905 1 probable transmembrane helix predicted for PFLU1391 by TMHMM2.0 at aa 12-31 216595006906 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 216595006907 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 216595006908 Beta-lactamase; Region: Beta-lactamase; cl01009 216595006910 1 probable transmembrane helix predicted for PFLU1395 by TMHMM2.0 at aa 7-24 216595006911 PS00294 Prenyl group binding site (CAAX box). 216595006912 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595006913 YceI-like domain; Region: YceI; cl01001 216595006915 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 216595006916 putative active site [active] 216595006917 catalytic site [active] 216595006918 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 216595006919 putative active site [active] 216595006920 catalytic site [active] 216595006923 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 216595006924 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 216595006925 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 216595006928 LemA family; Region: LemA; cl00742 216595006930 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595006931 Domain of unknown function (DUF477); Region: DUF477; cl01535 216595006932 2 probable transmembrane helices predicted for PFLU1401 by TMHMM2.0 at aa 10-32 and 180-202 216595006934 Domain of unknown function (DUF477); Region: DUF477; cl01535 216595006936 2 probable transmembrane helices predicted for PFLU1402 by TMHMM2.0 at aa 72-94 and 98-120 216595006938 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 216595006939 EamA-like transporter family; Region: EamA; cl01037 216595006942 Secretin and TonB N terminus short domain; Region: STN; cl06624 216595006943 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 216595006944 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216595006945 N-terminal plug; other site 216595006946 ligand-binding site [chemical binding]; other site 216595006950 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 216595006951 FecR protein; Region: FecR; pfam04773 216595006953 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216595006954 RNA polymerase sigma factor; Reviewed; Region: PRK12527 216595006955 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 216595006956 DNA binding residues [nucleotide binding] 216595006959 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 216595006960 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 216595006961 inhibitor site; inhibition site 216595006962 active site 216595006963 dimer interface [polypeptide binding]; other site 216595006964 catalytic residue [active] 216595006966 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 216595006967 intersubunit interface [polypeptide binding]; other site 216595006968 active site 216595006969 Zn2+ binding site [ion binding]; other site 216595006971 PS00070 Aldehyde dehydrogenases cysteine active site. 216595006972 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216595006973 non-specific DNA binding site [nucleotide binding]; other site 216595006974 salt bridge; other site 216595006975 sequence-specific DNA binding site [nucleotide binding]; other site 216595006976 Cupin domain; Region: Cupin_2; cl09118 216595006979 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 216595006980 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 216595006981 dimer interface [polypeptide binding]; other site 216595006982 active site 216595006983 metal binding site [ion binding]; metal-binding site 216595006985 PS00913 Iron-containing alcohol dehydrogenases signature 1. 216595006986 PS00060 Iron-containing alcohol dehydrogenases signature 2. 216595006987 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595006988 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 216595006989 putative substrate translocation pore; other site 216595006991 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595006992 NAD(P) binding site [chemical binding]; other site 216595006993 active site 216595006994 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595006995 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595006996 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 216595006997 putative dimerization interface [polypeptide binding]; other site 216595006999 PS00044 Bacterial regulatory proteins, lysR family signature. 216595007001 CoA-transferase family III; Region: CoA_transf_3; cl00778 216595007003 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 216595007004 active site 216595007005 catalytic residues [active] 216595007006 metal binding site [ion binding]; metal-binding site 216595007008 PS00059 Zinc-containing alcohol dehydrogenases signature. 216595007009 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 216595007010 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595007011 putative substrate translocation pore; other site 216595007012 12 probable transmembrane helices predicted for PFLU1418 by TMHMM2.0 at aa 21-43, 67-89, 96-115, 125-147, 154-176, 189-211, 254-276, 286-308, 321-340, 345-367, 374-396 and 411-433 216595007014 Protein of unknown function, DUF606; Region: DUF606; cl01273 216595007016 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595007017 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595007018 The C-terminal substrate binding domain of LysR-type transcriptional regulator ToxR regulates the expression of the toxoflavin biosynthesis genes; contains the type 2 periplasmic bindinig fold; Region: PBP2_ToxR; cd08465 216595007019 putative substrate binding pocket [chemical binding]; other site 216595007020 putative dimerization interface [polypeptide binding]; other site 216595007022 PS00044 Bacterial regulatory proteins, lysR family signature. 216595007024 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 216595007025 active site 216595007026 metal binding site [ion binding]; metal-binding site 216595007028 LysE type translocator; Region: LysE; cl00565 216595007029 6 probable transmembrane helices predicted for PFLU1422 by TMHMM2.0 at aa 10-32, 39-61, 71-90, 111-133, 148-170 and 182-204 216595007031 Predicted outer membrane protein [Function unknown]; Region: COG3652 216595007032 Low affinity iron permease; Region: Iron_permease; cl12096 216595007034 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 216595007035 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 216595007036 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 216595007037 DNA binding site [nucleotide binding] 216595007038 active site 216595007041 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 216595007043 YcfA-like protein; Region: YcfA; cl00752 216595007045 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 216595007046 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595007047 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 216595007048 dimerization interface [polypeptide binding]; other site 216595007049 substrate binding pocket [chemical binding]; other site 216595007052 PS00044 Bacterial regulatory proteins, lysR family signature. 216595007053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595007054 putative substrate translocation pore; other site 216595007055 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216595007056 12 probable transmembrane helices predicted for PFLU1430 by TMHMM2.0 at aa 36-58, 73-95, 102-121, 127-149, 162-181, 196-213, 233-255, 265-287, 299-316, 321-343, 356-378 and 383-405 216595007058 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595007059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595007061 9 probable transmembrane helices predicted for PFLU1431 by TMHMM2.0 at aa 35-57, 78-100, 171-193, 213-235, 250-272, 284-301, 306-328, 341-363 and 367-389 216595007062 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 216595007063 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595007064 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216595007066 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 216595007067 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 216595007068 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 216595007069 active site 216595007070 uracil binding [chemical binding]; other site 216595007072 PS01149 Rsu family of pseudouridine synthase signature. 216595007074 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 216595007075 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595007076 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595007077 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595007080 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595007081 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 216595007082 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 216595007083 substrate binding site [chemical binding]; other site 216595007084 oxyanion hole (OAH) forming residues; other site 216595007085 trimer interface [polypeptide binding]; other site 216595007087 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 216595007088 ligand binding site [chemical binding]; other site 216595007089 active site 216595007090 UGI interface [polypeptide binding]; other site 216595007091 catalytic site [active] 216595007093 PS00130 Uracil-DNA glycosylase signature. 216595007094 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases...; Region: PL1_Passenger_AT; cd01343 216595007095 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 216595007096 Autotransporter beta-domain; Region: Autotransporter; cl02365 216595007097 1 probable transmembrane helix predicted for PFLU1444 by TMHMM2.0 at aa 7-29 216595007100 Class II transport system: TTT 216595007101 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 216595007102 Putative ammonia monooxygenase; Region: AmoA; pfam05145 216595007103 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 216595007105 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 216595007107 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 216595007108 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 216595007109 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 216595007111 outer membrane porin, OprD family; Region: OprD; pfam03573 216595007113 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 216595007114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595007115 active site 216595007116 phosphorylation site [posttranslational modification] 216595007117 intermolecular recognition site; other site 216595007118 dimerization interface [polypeptide binding]; other site 216595007119 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 216595007120 DNA binding site [nucleotide binding] 216595007123 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 216595007124 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595007125 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595007126 dimer interface [polypeptide binding]; other site 216595007127 phosphorylation site [posttranslational modification] 216595007128 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595007129 ATP binding site [chemical binding]; other site 216595007130 Mg2+ binding site [ion binding]; other site 216595007131 G-X-G motif; other site 216595007132 2 probable transmembrane helices predicted for PFLU1452 by TMHMM2.0 at aa 10-32 and 172-194 216595007137 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 216595007138 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 216595007140 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 216595007141 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 216595007143 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 216595007145 1 probable transmembrane helix predicted for PFLU1456 by TMHMM2.0 at aa 10-32 216595007147 PFI-3 216595007148 Phage integrase family; Region: Phage_integrase; pfam00589 216595007149 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 216595007150 DNA binding site [nucleotide binding] 216595007151 Int/Topo IB signature motif; other site 216595007152 active site 216595007154 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 216595007155 PS00430 TonB-dependent receptor proteins signature 1. 216595007156 L-aspartate oxidase; Provisional; Region: PRK09077 216595007157 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595007158 domain; Region: Succ_DH_flav_C; pfam02910 216595007161 RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923 216595007162 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216595007163 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 216595007164 DNA binding residues [nucleotide binding] 216595007166 PS01063 Sigma-70 factors ECF subfamily signature. 216595007168 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073 216595007169 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 216595007170 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 216595007173 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 216595007175 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 216595007176 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 216595007177 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 216595007178 protein binding site [polypeptide binding]; other site 216595007179 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 216595007180 protein binding site [polypeptide binding]; other site 216595007184 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 216595007185 Peptidase family M48; Region: Peptidase_M48; cl12018 216595007187 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 216595007188 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-...; Region: SirA_YedF_YeeD; cd00291 216595007189 CPxP motif; other site 216595007191 PS01148 Uncharacterized protein family UPF0033 signature. 216595007192 Domain of unknown function DUF20; Region: UPF0118; cl00465 216595007194 7 probable transmembrane helices predicted for PFLU1474 by TMHMM2.0 at aa 20-52, 72-94, 156-178, 218-235, 245-267, 279-301 and 311-333 216595007195 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 216595007196 catalytic triad [active] 216595007198 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 216595007199 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 216595007200 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 216595007201 dihydrodipicolinate synthase; Region: dapA; TIGR00674 216595007202 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 216595007203 dimer interface [polypeptide binding]; other site 216595007204 active site 216595007205 catalytic residue [active] 216595007207 PS00665 Dihydrodipicolinate synthetase signature 1. 216595007208 PS00666 Dihydrodipicolinate synthetase signature 2. 216595007209 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 216595007210 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 216595007211 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595007212 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 216595007214 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 216595007215 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 216595007216 ATP binding site [chemical binding]; other site 216595007217 active site 216595007218 substrate binding site [chemical binding]; other site 216595007220 PS01057 SAICAR synthetase signature 1. 216595007221 PS01058 SAICAR synthetase signature 2. 216595007222 Colicin pore forming domain; Region: Colicin; pfam01024 216595007224 PS00017 ATP/GTP-binding site motif A (P-loop). 216595007225 1 probable transmembrane helix predicted for PFLU1482 by TMHMM2.0 at aa 390-412 216595007226 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 216595007227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595007228 putative substrate translocation pore; other site 216595007230 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 216595007231 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595007232 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595007233 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595007234 2 probable transmembrane helices predicted for PFLU1485 by TMHMM2.0 at aa 15-37 and 192-211 216595007237 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595007238 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595007239 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 216595007240 putative dimerization interface [polypeptide binding]; other site 216595007242 PS00044 Bacterial regulatory proteins, lysR family signature. 216595007244 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595007245 citrate-proton symporter; Provisional; Region: PRK15075 216595007246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595007247 putative substrate translocation pore; other site 216595007249 PS00216 Sugar transport proteins signature 1. 216595007250 PS00217 Sugar transport proteins signature 2. 216595007251 PS00216 Sugar transport proteins signature 1. 216595007252 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595007253 DNA-binding site [nucleotide binding]; DNA binding site 216595007254 FCD domain; Region: FCD; cl11656 216595007257 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216595007258 classical (c) SDRs; Region: SDR_c; cd05233 216595007259 NAD(P) binding site [chemical binding]; other site 216595007260 active site 216595007262 PS00061 Short-chain dehydrogenases/reductases family signature. 216595007263 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl01276 216595007265 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 216595007267 5 probable transmembrane helices predicted for PFLU1494 by TMHMM2.0 at aa 27-44, 67-89, 101-118, 169-188 and 195-217 216595007269 6 probable transmembrane helices predicted for PFLU1495 by TMHMM2.0 at aa 5-27, 34-56, 66-88, 95-117, 132-154 and 161-183 216595007270 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 216595007271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595007272 putative substrate translocation pore; other site 216595007273 12 probable transmembrane helices predicted for PFLU1496 by TMHMM2.0 at aa 41-58, 73-95, 108-130, 136-158, 171-193, 203-222, 271-293, 303-325, 338-355, 360-382, 389-411 and 421-443 216595007275 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595007276 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595007277 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 216595007278 putative substrate binding pocket [chemical binding]; other site 216595007279 putative dimerization interface [polypeptide binding]; other site 216595007282 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 216595007283 putative substrate binding pocket [chemical binding]; other site 216595007284 trimer interface [polypeptide binding]; other site 216595007286 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595007287 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595007288 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 216595007289 substrate binding pocket [chemical binding]; other site 216595007290 dimerization interface [polypeptide binding]; other site 216595007293 PS00044 Bacterial regulatory proteins, lysR family signature. 216595007294 putative cyanate transporter; Provisional; Region: cynX; PRK09705 216595007295 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595007296 putative substrate translocation pore; other site 216595007298 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216595007299 Arabidopsis betaine aldehyde dehydrogenase 1 and 2, ALDH family 10A8 and 10A9-like; Region: ALDH_F10_BADH; cd07110 216595007300 NAD(P) binding site [chemical binding]; other site 216595007301 catalytic residues [active] 216595007302 catalytic residues [active] 216595007304 PS00070 Aldehyde dehydrogenases cysteine active site. 216595007305 hypothetical protein; Provisional; Region: PRK07524 216595007306 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 216595007307 PYR/PP interface [polypeptide binding]; other site 216595007308 dimer interface [polypeptide binding]; other site 216595007309 TPP binding site [chemical binding]; other site 216595007310 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 216595007311 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cd00568 216595007312 TPP-binding site [chemical binding]; other site 216595007316 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 216595007317 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595007318 HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 216595007319 substrate binding pocket [chemical binding]; other site 216595007320 dimerization interface [polypeptide binding]; other site 216595007322 PS00044 Bacterial regulatory proteins, lysR family signature. 216595007324 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595007325 NAD(P) binding site [chemical binding]; other site 216595007326 active site 216595007328 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 216595007330 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595007331 transcriptional activator TtdR; Provisional; Region: PRK09801 216595007332 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 216595007333 putative effector binding pocket; other site 216595007334 dimerization interface [polypeptide binding]; other site 216595007337 1 probable transmembrane helix predicted for PFLU1508 by TMHMM2.0 at aa 7-29 216595007338 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 216595007339 Cupin domain; Region: Cupin_2; cl09118 216595007340 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595007342 PS00041 Bacterial regulatory proteins, araC family signature. 216595007344 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 216595007345 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595007347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595007348 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216595007349 putative substrate translocation pore; other site 216595007350 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595007351 13 probable transmembrane helices predicted for PFLU1511 by TMHMM2.0 at aa 20-42, 55-77, 87-105, 112-134, 171-193, 206-228, 241-258, 271-293, 313-332, 344-363, 368-390, 410-432 and 481-503 216595007353 Cache domain; Region: Cache_2; cl07034 216595007355 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 216595007356 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595007357 substrate binding pocket [chemical binding]; other site 216595007358 membrane-bound complex binding site; other site 216595007359 hinge residues; other site 216595007361 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 216595007362 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 216595007364 PS00181 Glutamine synthetase putative ATP-binding region signature. 216595007365 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 216595007366 S-adenosylmethionine binding site [chemical binding]; other site 216595007368 ribonuclease D; Region: rnd; TIGR01388 216595007369 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 216595007370 putative active site [active] 216595007371 catalytic site [active] 216595007372 putative substrate binding site [chemical binding]; other site 216595007373 HRDC domain; Region: HRDC; cl02578 216595007376 YcgL domain; Region: YcgL; cl01189 216595007378 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 216595007379 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595007381 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 216595007382 putative FMN binding site [chemical binding]; other site 216595007384 Flagellin N-methylase; Region: FliB; cl00497 216595007386 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 216595007387 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 216595007388 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 216595007390 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 216595007392 PS00190 Cytochrome c family heme-binding site signature. 216595007393 Putative ParB-like nuclease; Region: ParBc_2; cl01772 216595007395 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 216595007396 PS00017 ATP/GTP-binding site motif A (P-loop). 216595007397 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216595007398 ligand binding site [chemical binding]; other site 216595007399 flexible hinge region; other site 216595007401 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 216595007402 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595007405 2 probable transmembrane helices predicted for PFLU1530 by TMHMM2.0 at aa 31-53 and 111-133 216595007406 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 216595007407 putative active site [active] 216595007408 putative dimer interface [polypeptide binding]; other site 216595007410 Protein of unknown function (DUF2937); Region: DUF2937; pfam11157 216595007411 2 probable transmembrane helices predicted for PFLU1532 by TMHMM2.0 at aa 5-24 and 134-156 216595007412 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595007413 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595007414 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 216595007415 dimerization interface [polypeptide binding]; other site 216595007418 PS00044 Bacterial regulatory proteins, lysR family signature. 216595007419 LamB/YcsF family; Region: LamB_YcsF; cl00664 216595007421 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 216595007422 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 216595007424 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 216595007425 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 216595007427 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 216595007428 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 216595007429 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595007430 Walker A motif; other site 216595007431 ATP binding site [chemical binding]; other site 216595007432 Walker B motif; other site 216595007433 arginine finger; other site 216595007435 PS00017 ATP/GTP-binding site motif A (P-loop). 216595007436 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 216595007437 1 probable transmembrane helix predicted for PFLU1539 by TMHMM2.0 at aa 7-29 216595007438 cysteine synthases; Region: cysKM; TIGR01136 216595007439 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 216595007440 dimer interface [polypeptide binding]; other site 216595007441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595007442 catalytic residue [active] 216595007444 PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. 216595007445 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl01426 216595007446 2 probable transmembrane helices predicted for PFLU1541 by TMHMM2.0 at aa 5-24 and 293-311 216595007448 aconitate hydratase; Validated; Region: PRK09277 216595007449 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 216595007450 substrate binding site [chemical binding]; other site 216595007451 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 216595007452 ligand binding site [chemical binding]; other site 216595007453 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 216595007454 substrate binding site [chemical binding]; other site 216595007457 PS01244 Aconitase family signature 2. 216595007458 PS00450 Aconitase family signature 1. 216595007459 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595007460 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 216595007461 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 216595007462 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 216595007463 CPxP motif; other site 216595007465 PS01148 Uncharacterized protein family UPF0033 signature. 216595007466 multidrug efflux protein; Reviewed; Region: PRK01766 216595007467 MatE; Region: MatE; cl10513 216595007468 MatE; Region: MatE; cl10513 216595007471 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 216595007472 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595007473 Domain of unknown function (DUF3410); Region: DUF3410; pfam11890 216595007476 PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 216595007477 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 216595007478 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 216595007479 MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249 216595007480 Walker A/P-loop; other site 216595007481 ATP binding site [chemical binding]; other site 216595007482 Q-loop/lid; other site 216595007483 ABC transporter signature motif; other site 216595007484 Walker B; other site 216595007485 D-loop; other site 216595007486 H-loop/switch region; other site 216595007487 6 probable transmembrane helices predicted for PFLU1548 by TMHMM2.0 at aa 21-43, 68-90, 146-163, 168-187, 250-272 and 287-309 216595007490 PS00017 ATP/GTP-binding site motif A (P-loop). 216595007491 PS00211 ABC transporters family signature. 216595007492 lytic murein transglycosylase; Provisional; Region: PRK11619 216595007493 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 216595007494 N-acetyl-D-glucosamine binding site [chemical binding]; other site 216595007495 catalytic residue [active] 216595007497 ABC transporter ATPase component; Reviewed; Region: PRK11147 216595007498 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595007499 Walker A/P-loop; other site 216595007500 ATP binding site [chemical binding]; other site 216595007501 Q-loop/lid; other site 216595007502 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 216595007503 ABC transporter signature motif; other site 216595007504 Walker B; other site 216595007505 D-loop; other site 216595007506 ABC transporter; Region: ABC_tran_2; pfam12848 216595007507 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 216595007509 PS00017 ATP/GTP-binding site motif A (P-loop). 216595007510 PS00211 ABC transporters family signature. 216595007512 PS00017 ATP/GTP-binding site motif A (P-loop). 216595007513 PS00211 ABC transporters family signature. 216595007514 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216595007515 Ligand Binding Site [chemical binding]; other site 216595007517 1 probable transmembrane helix predicted for PFLU1552 by TMHMM2.0 at aa 4-23 216595007518 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 216595007519 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 216595007520 substrate binding site [chemical binding]; other site 216595007521 oxyanion hole (OAH) forming residues; other site 216595007522 trimer interface [polypeptide binding]; other site 216595007523 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 216595007524 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 216595007526 PS00166 Enoyl-CoA hydratase/isomerase signature. 216595007528 PS00067 3-hydroxyacyl-CoA dehydrogenase signature. 216595007530 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 216595007531 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 216595007532 dimer interface [polypeptide binding]; other site 216595007533 active site 216595007535 PS00098 Thiolases acyl-enzyme intermediate signature. 216595007536 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 216595007538 PS00737 Thiolases signature 2. 216595007539 PS00099 Thiolases active site. 216595007540 Protein of unknown function (DUF1653); Region: DUF1653; cl01949 216595007541 PS00430 TonB-dependent receptor proteins signature 1. 216595007543 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 216595007544 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363 216595007545 active site 216595007546 interdomain interaction site; other site 216595007547 putative metal-binding site [ion binding]; other site 216595007548 nucleotide binding site [chemical binding]; other site 216595007549 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 216595007550 domain I; other site 216595007551 DNA binding groove [nucleotide binding] 216595007552 phosphate binding site [ion binding]; other site 216595007553 domain II; other site 216595007554 domain III; other site 216595007555 nucleotide binding site [chemical binding]; other site 216595007556 catalytic site [active] 216595007557 domain IV; other site 216595007558 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 216595007559 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 216595007560 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 216595007563 PS00396 Prokaryotic DNA topoisomerase I active site. 216595007568 Cell division inhibitor SulA; Region: SulA; cl01880 216595007569 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595007570 LexA repressor; Validated; Region: PRK00215 216595007571 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 216595007572 Catalytic site [active] 216595007575 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 216595007576 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216595007577 Protein of unknown function (DUF3179); Region: DUF3179; pfam11376 216595007579 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 216595007581 PS00775 Glycosyl hydrolases family 3 active site. 216595007582 Uncharacterized conserved protein [Function unknown]; Region: COG4715 216595007583 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 216595007584 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216595007585 ATP binding site [chemical binding]; other site 216595007586 putative Mg++ binding site [ion binding]; other site 216595007587 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216595007588 nucleotide binding region [chemical binding]; other site 216595007589 ATP-binding site [chemical binding]; other site 216595007591 PS00030 Eukaryotic putative RNA-binding region RNP-1 signature. 216595007594 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 216595007595 transcription-repair coupling factor; Provisional; Region: PRK10689 216595007596 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 216595007597 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216595007598 ATP binding site [chemical binding]; other site 216595007599 putative Mg++ binding site [ion binding]; other site 216595007600 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216595007601 nucleotide binding region [chemical binding]; other site 216595007602 ATP-binding site [chemical binding]; other site 216595007603 TRCF domain; Region: TRCF; cl04088 216595007605 PS00107 Protein kinases ATP-binding region signature. 216595007608 PS00017 ATP/GTP-binding site motif A (P-loop). 216595007610 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 216595007611 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 216595007612 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 216595007614 PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. 216595007616 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 216595007617 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595007618 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 216595007621 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595007623 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 216595007624 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 216595007625 active site 216595007626 catalytic site [active] 216595007628 PilZ domain; Region: PilZ; cl01260 216595007630 LolC/E family; Region: lolCE; TIGR02212 216595007631 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 216595007632 FtsX-like permease family; Region: FtsX; pfam02687 216595007633 4 probable transmembrane helices predicted for PFLU1572 by TMHMM2.0 at aa 21-43, 274-296, 317-339 and 382-404 216595007635 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 216595007636 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 216595007637 Walker A/P-loop; other site 216595007638 ATP binding site [chemical binding]; other site 216595007639 Q-loop/lid; other site 216595007640 ABC transporter signature motif; other site 216595007641 Walker B; other site 216595007642 D-loop; other site 216595007643 H-loop/switch region; other site 216595007645 PS00017 ATP/GTP-binding site motif A (P-loop). 216595007646 PS00211 ABC transporters family signature. 216595007647 LolC/E family; Region: lolCE; TIGR02212 216595007648 FtsX-like permease family; Region: FtsX; pfam02687 216595007649 4 probable transmembrane helices predicted for PFLU1574 by TMHMM2.0 at aa 21-43, 272-294, 315-337 and 375-397 216595007651 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 216595007652 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595007653 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595007654 dimer interface [polypeptide binding]; other site 216595007655 phosphorylation site [posttranslational modification] 216595007656 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595007657 ATP binding site [chemical binding]; other site 216595007658 Mg2+ binding site [ion binding]; other site 216595007659 G-X-G motif; other site 216595007663 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 216595007664 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595007665 active site 216595007666 phosphorylation site [posttranslational modification] 216595007667 intermolecular recognition site; other site 216595007668 dimerization interface [polypeptide binding]; other site 216595007669 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 216595007670 DNA binding site [nucleotide binding] 216595007673 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 216595007675 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 216595007676 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 216595007678 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 216595007679 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595007680 ggaaccnnnnnnnnnnnnnnnnccacnna 216595007681 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595007682 VacJ like lipoprotein; Region: VacJ; cl01073 216595007684 PilZ domain; Region: PilZ; cl01260 216595007686 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 216595007687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595007688 active site 216595007689 phosphorylation site [posttranslational modification] 216595007690 intermolecular recognition site; other site 216595007691 dimerization interface [polypeptide binding]; other site 216595007692 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 216595007695 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 216595007696 anti sigma factor interaction site; other site 216595007697 regulatory phosphorylation site [posttranslational modification]; other site 216595007700 transaldolase-like protein; Provisional; Region: PTZ00411 216595007701 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 216595007702 active site 216595007703 dimer interface [polypeptide binding]; other site 216595007704 catalytic residue [active] 216595007706 PS00958 Transaldolase active site. 216595007707 PS01054 Transaldolase signature 1. 216595007708 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 216595007709 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 216595007710 FMN binding site [chemical binding]; other site 216595007711 active site 216595007712 catalytic residues [active] 216595007713 substrate binding site [chemical binding]; other site 216595007715 PS01136 Uncharacterized protein family UPF0034 signature. 216595007716 Prophage 2 216595007717 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 216595007718 Phage integrase family; Region: Phage_integrase; pfam00589 216595007719 DNA binding site [nucleotide binding] 216595007720 Int/Topo IB signature motif; other site 216595007721 active site 216595007723 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 216595007725 capsid-scaffolding protein; Provisional; Region: O; PHA02529 216595007726 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929 216595007728 terminase ATPase subunit; Provisional; Region: P; PHA02535 216595007729 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 216595007730 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 216595007733 Phage-related protein [Function unknown]; Region: COG4695; cl01923 216595007734 phage portal protein, PBSX family; Region: portal_PBSX; TIGR01540 216595007736 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 216595007738 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 216595007739 synthetase active site [active] 216595007740 NTP binding site [chemical binding]; other site 216595007741 metal binding site [ion binding]; metal-binding site 216595007744 Chain length determinant protein; Region: Wzz; cl01623 216595007745 1 probable transmembrane helix predicted for PFLU1601 by TMHMM2.0 at aa 189-211 216595007747 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 216595007748 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595007749 putative substrate translocation pore; other site 216595007751 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 216595007752 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595007753 dimer interface [polypeptide binding]; other site 216595007754 phosphorylation site [posttranslational modification] 216595007755 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595007756 ATP binding site [chemical binding]; other site 216595007757 G-X-G motif; other site 216595007758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595007759 active site 216595007760 phosphorylation site [posttranslational modification] 216595007761 intermolecular recognition site; other site 216595007762 dimerization interface [polypeptide binding]; other site 216595007763 1 probable transmembrane helix predicted for PFLU1603 by TMHMM2.0 at aa 64-86 216595007767 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 216595007768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595007769 active site 216595007770 phosphorylation site [posttranslational modification] 216595007771 intermolecular recognition site; other site 216595007772 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216595007775 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 216595007776 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595007777 dimer interface [polypeptide binding]; other site 216595007778 phosphorylation site [posttranslational modification] 216595007779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595007780 ATP binding site [chemical binding]; other site 216595007781 Mg2+ binding site [ion binding]; other site 216595007782 G-X-G motif; other site 216595007783 Response regulator receiver domain; Region: Response_reg; pfam00072 216595007784 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595007785 active site 216595007786 phosphorylation site [posttranslational modification] 216595007787 intermolecular recognition site; other site 216595007788 dimerization interface [polypeptide binding]; other site 216595007789 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 216595007790 2 probable transmembrane helices predicted for PFLU1605 by TMHMM2.0 at aa 37-59 and 349-371 216595007791 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595007795 PS00070 Aldehyde dehydrogenases cysteine active site. 216595007797 transcriptional regulator RcsB; Provisional; Region: PRK10840 216595007798 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595007799 active site 216595007800 phosphorylation site [posttranslational modification] 216595007801 intermolecular recognition site; other site 216595007802 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 216595007803 DNA binding residues [nucleotide binding] 216595007804 dimerization interface [polypeptide binding]; other site 216595007807 PS00622 Bacterial regulatory proteins, luxR family signature. 216595007808 Fimbrial protein; Region: Fimbrial; cl01416 216595007810 Fimbrial protein; Region: Fimbrial; cl01416 216595007812 Fimbrial Usher protein; Region: Usher; pfam00577 216595007813 pilin outer membrane usher protein SafC; Provisional; Region: PRK15223; cl14650 216595007815 PS01151 Fimbrial biogenesis outer membrane usher protein signature. 216595007816 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 216595007817 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 216595007818 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 216595007820 Fimbrial protein; Region: Fimbrial; cl01416 216595007822 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 216595007823 Predicted dehydrogenase [General function prediction only]; Region: COG0579 216595007825 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 216595007826 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595007828 PS00017 ATP/GTP-binding site motif A (P-loop). 216595007829 transcriptional regulator; Provisional; Region: PRK10632 216595007830 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595007831 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 216595007832 putative effector binding pocket; other site 216595007833 putative dimerization interface [polypeptide binding]; other site 216595007835 PS00044 Bacterial regulatory proteins, lysR family signature. 216595007837 1 probable transmembrane helix predicted for PFLU1616 by TMHMM2.0 at aa 10-29 216595007838 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595007839 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 216595007841 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 216595007842 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 216595007844 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl01426 216595007846 1 probable transmembrane helix predicted for PFLU1620 by TMHMM2.0 at aa 13-35 216595007847 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 216595007848 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 216595007849 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595007850 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 216595007852 Anthrax toxin LF subunit; Region: Anthrax_toxA; pfam03497 216595007854 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595007855 LysR family transcriptional regulator; Provisional; Region: PRK14997 216595007856 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 216595007857 putative effector binding pocket; other site 216595007858 putative dimerization interface [polypeptide binding]; other site 216595007861 PS00044 Bacterial regulatory proteins, lysR family signature. 216595007862 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595007863 acetylornithine aminotransferase; Provisional; Region: PRK02627 216595007864 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 216595007865 inhibitor-cofactor binding pocket; inhibition site 216595007866 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595007867 catalytic residue [active] 216595007869 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 216595007870 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 216595007871 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595007872 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595007873 dimerization interface [polypeptide binding]; other site 216595007876 PS00044 Bacterial regulatory proteins, lysR family signature. 216595007877 putative transporter; Provisional; Region: PRK11043 216595007878 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595007879 12 probable transmembrane helices predicted for PFLU1626 by TMHMM2.0 at aa 7-29, 39-61, 73-92, 97-119, 131-153, 157-179, 210-232, 242-260, 273-295, 300-322, 335-357 and 361-383 216595007881 Permease family; Region: Xan_ur_permease; pfam00860 216595007882 Sulfate transporter family; Region: Sulfate_transp; cl00967 216595007884 12 probable transmembrane helices predicted for PFLU1628 by TMHMM2.0 at aa 56-76, 81-103, 110-129, 134-156, 163-185, 195-217, 224-246, 266-288, 351-370, 375-397, 410-427 and 437-459 216595007885 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 216595007886 PS01116 Xanthine/uracil permeases family signature. 216595007887 PS00012 Phosphopantetheine attachment site. 216595007888 proline-specific peptidases, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 216595007890 Autoinducer binding domain; Region: Autoind_bind; pfam03472 216595007891 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 216595007892 DNA binding residues [nucleotide binding] 216595007893 dimerization interface [polypeptide binding]; other site 216595007896 proline-specific peptidases, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 216595007898 PS00120 Lipases, serine active site. 216595007899 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216595007900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595007901 dimer interface [polypeptide binding]; other site 216595007902 conserved gate region; other site 216595007903 putative PBP binding loops; other site 216595007904 ABC-ATPase subunit interface; other site 216595007905 6 probable transmembrane helices predicted for PFLU1632 by TMHMM2.0 at aa 13-35, 102-124, 144-166, 181-198, 249-271 and 286-308 216595007906 PS00215 Mitochondrial energy transfer proteins signature. 216595007908 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595007909 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 216595007910 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595007911 dimer interface [polypeptide binding]; other site 216595007912 conserved gate region; other site 216595007913 putative PBP binding loops; other site 216595007914 ABC-ATPase subunit interface; other site 216595007915 6 probable transmembrane helices predicted for PFLU1633 by TMHMM2.0 at aa 25-47, 92-114, 127-145, 150-167, 214-236 and 251-273 216595007917 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 216595007918 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 216595007919 Walker A/P-loop; other site 216595007920 ATP binding site [chemical binding]; other site 216595007921 Q-loop/lid; other site 216595007922 ABC transporter signature motif; other site 216595007923 Walker B; other site 216595007924 D-loop; other site 216595007925 H-loop/switch region; other site 216595007926 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216595007928 PS00017 ATP/GTP-binding site motif A (P-loop). 216595007929 PS00211 ABC transporters family signature. 216595007931 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 216595007932 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 216595007933 Walker A/P-loop; other site 216595007934 ATP binding site [chemical binding]; other site 216595007935 Q-loop/lid; other site 216595007936 ABC transporter signature motif; other site 216595007937 Walker B; other site 216595007938 D-loop; other site 216595007939 H-loop/switch region; other site 216595007940 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216595007942 PS00017 ATP/GTP-binding site motif A (P-loop). 216595007943 PS00211 ABC transporters family signature. 216595007945 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 216595007946 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 216595007947 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595007949 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595007950 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 216595007951 NAD(P) binding site [chemical binding]; other site 216595007952 active site 216595007954 PS00061 Short-chain dehydrogenases/reductases family signature. 216595007956 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 216595007957 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 216595007958 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 216595007959 motif II; other site 216595007961 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 216595007962 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 216595007963 S-adenosylmethionine binding site [chemical binding]; other site 216595007965 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 216595007966 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 216595007967 active site 216595007968 putative substrate binding pocket [chemical binding]; other site 216595007970 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 216595007971 Initiation factor 2 subunit family; Region: IF-2B; pfam01008 216595007973 DNA gyrase subunit A; Validated; Region: PRK05560 216595007974 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 216595007975 CAP-like domain; other site 216595007976 Active site [active] 216595007977 primary dimer interface [polypeptide binding]; other site 216595007978 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 216595007979 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 216595007980 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 216595007981 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 216595007982 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 216595007983 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 216595007991 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active...; Region: PSAT_like; cd00611 216595007992 homodimer interface [polypeptide binding]; other site 216595007993 substrate-cofactor binding pocket; other site 216595007994 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 216595007995 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595007996 catalytic residue [active] 216595007998 Chorismate mutase type II; Region: CM_2; cl00693 216595007999 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 216595008000 Prephenate dehydratase; Region: PDT; pfam00800 216595008001 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 216595008002 putative L-Phe binding site [chemical binding]; other site 216595008005 PS00857 Prephenate dehydratase signature 1. 216595008007 PS00858 Prephenate dehydratase signature 2. 216595008008 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 216595008009 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216595008010 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595008011 homodimer interface [polypeptide binding]; other site 216595008012 catalytic residue [active] 216595008014 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 216595008015 bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK14806 216595008016 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595008017 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556 216595008018 hinge; other site 216595008019 active site 216595008022 PS00104 EPSP synthase signature 1. 216595008023 PS00017 ATP/GTP-binding site motif A (P-loop). 216595008024 cytidylate kinase; Provisional; Region: cmk; PRK00023 216595008025 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 216595008026 CMP-binding site; other site 216595008027 The sites determining sugar specificity; other site 216595008029 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 216595008030 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 216595008031 RNA binding site [nucleotide binding]; other site 216595008032 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 216595008033 RNA binding site [nucleotide binding]; other site 216595008034 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 216595008035 RNA binding site [nucleotide binding]; other site 216595008036 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 216595008037 RNA binding site [nucleotide binding]; other site 216595008038 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 216595008039 RNA binding site [nucleotide binding]; other site 216595008040 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec6; cd05691 216595008041 RNA binding site [nucleotide binding]; other site 216595008048 PFI-4 216595008049 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595008050 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 216595008051 IHF dimer interface [polypeptide binding]; other site 216595008052 IHF - DNA interface [nucleotide binding]; other site 216595008054 PS00045 Bacterial histone-like DNA-binding proteins signature. 216595008055 2 probable transmembrane helices predicted for PFLU1652 by TMHMM2.0 at aa 7-25 and 45-67 216595008056 MatE; Region: MatE; cl10513 216595008058 11 probable transmembrane helices predicted for PFLU1653 by TMHMM2.0 at aa 4-26, 46-68, 88-110, 119-141, 145-167, 188-207, 231-253, 273-295, 305-327, 336-355 and 359-381 216595008059 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 216595008060 active site 216595008061 11 probable transmembrane helices predicted for PFLU1656 by TMHMM2.0 at aa 21-40, 44-66, 78-100, 110-132, 139-158, 178-200, 207-229, 234-251, 256-278, 340-358 and 371-393 216595008062 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 216595008063 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 216595008064 NAD(P) binding site [chemical binding]; other site 216595008065 homodimer interface [polypeptide binding]; other site 216595008066 substrate binding site [chemical binding]; other site 216595008067 active site 216595008068 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 216595008071 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 216595008072 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 216595008073 putative NAD(P) binding site [chemical binding]; other site 216595008074 active site 216595008075 putative substrate binding site [chemical binding]; other site 216595008076 Cupin domain; Region: Cupin_2; cl09118 216595008078 PS00061 Short-chain dehydrogenases/reductases family signature. 216595008079 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 216595008080 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues...; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 216595008081 active site 216595008082 homodimer interface [polypeptide binding]; other site 216595008084 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 216595008085 putative glycosyl transferase; Provisional; Region: PRK10307 216595008088 1 probable transmembrane helix predicted for PFLU1661 by TMHMM2.0 at aa 7-29 216595008089 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 216595008090 iron-sulfur cluster [ion binding]; other site 216595008091 [2Fe-2S] cluster binding site [ion binding]; other site 216595008092 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 216595008093 alpha subunit interface [polypeptide binding]; other site 216595008094 active site 216595008095 substrate binding site [chemical binding]; other site 216595008096 Fe binding site [ion binding]; other site 216595008098 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 216595008099 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 216595008100 dimer interface [polypeptide binding]; other site 216595008101 active site 216595008102 CoA binding pocket [chemical binding]; other site 216595008105 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216595008106 classical (c) SDRs; Region: SDR_c; cd05233 216595008107 NAD(P) binding site [chemical binding]; other site 216595008108 active site 216595008110 PS00061 Short-chain dehydrogenases/reductases family signature. 216595008111 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 216595008112 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 216595008113 putative trimer interface [polypeptide binding]; other site 216595008114 putative CoA binding site [chemical binding]; other site 216595008119 PS00101 Hexapeptide-repeat containing-transferases signature. 216595008121 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 216595008122 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 216595008123 dimer interface [polypeptide binding]; other site 216595008124 active site 216595008125 CoA binding pocket [chemical binding]; other site 216595008128 PS00017 ATP/GTP-binding site motif A (P-loop). 216595008129 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 216595008130 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 216595008131 inhibitor-cofactor binding pocket; inhibition site 216595008132 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595008133 catalytic residue [active] 216595008135 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 216595008136 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 216595008137 NAD(P) binding site [chemical binding]; other site 216595008138 homodimer interface [polypeptide binding]; other site 216595008139 substrate binding site [chemical binding]; other site 216595008140 active site 216595008141 4 probable transmembrane helices predicted for PFLU1668 by TMHMM2.0 at aa 30-47, 54-76, 89-111 and 124-141 216595008143 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 216595008144 1 probable transmembrane helix predicted for PFLU1669 by TMHMM2.0 at aa 11-33 216595008145 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216595008146 PS01148 Uncharacterized protein family UPF0033 signature. 216595008148 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216595008149 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595008150 DNA-binding site [nucleotide binding]; DNA binding site 216595008151 FCD domain; Region: FCD; cl11656 216595008154 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 216595008155 Protein of unknown function (DUF2897); Region: DUF2897; pfam11446 216595008156 1 probable transmembrane helix predicted for PFLU1673 by TMHMM2.0 at aa 15-37 216595008157 ethanolamine permease; Region: 2A0305; TIGR00908 216595008158 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 216595008160 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; cl00903 216595008161 Potassium-transporting ATPase A subunit; Region: KdpA; pfam03814 216595008162 10 probable transmembrane helices predicted for PFLU1676 by TMHMM2.0 at aa 6-28, 66-88, 134-156, 177-199, 252-274, 286-305, 375-397, 418-440, 487-509 and 530-552 216595008164 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 216595008165 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216595008166 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 216595008167 7 probable transmembrane helices predicted for PFLU1677 by TMHMM2.0 at aa 48-70, 74-96, 227-249, 259-281, 592-614, 624-646 and 659-681 216595008170 PS00154 E1-E2 ATPases phosphorylation site. 216595008171 PS01229 Hypothetical cof family signature 2. 216595008173 K+-transporting ATPase, c chain; Region: KdpC; cl00944 216595008175 1 probable transmembrane helix predicted for PFLU1678 by TMHMM2.0 at aa 13-35 216595008176 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 216595008177 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 216595008178 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 216595008179 Ligand Binding Site [chemical binding]; other site 216595008180 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595008181 dimer interface [polypeptide binding]; other site 216595008182 phosphorylation site [posttranslational modification] 216595008183 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595008184 ATP binding site [chemical binding]; other site 216595008185 Mg2+ binding site [ion binding]; other site 216595008186 G-X-G motif; other site 216595008188 PS00017 ATP/GTP-binding site motif A (P-loop). 216595008190 4 probable transmembrane helices predicted for PFLU1679 by TMHMM2.0 at aa 385-407, 414-433, 437-459 and 466-484 216595008193 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 216595008194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595008195 active site 216595008196 phosphorylation site [posttranslational modification] 216595008197 intermolecular recognition site; other site 216595008198 dimerization interface [polypeptide binding]; other site 216595008199 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 216595008200 DNA binding site [nucleotide binding] 216595008203 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 216595008204 active site 216595008205 nucleophile elbow; other site 216595008206 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 216595008208 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595008209 CHAD domain; Region: CHAD; cl10506 216595008211 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 216595008212 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 216595008213 active site 216595008214 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 216595008215 active site 2 [active] 216595008216 active site 1 [active] 216595008217 Protein of unknown function (DUF962); Region: DUF962; cl01879 216595008218 Terminase small subunit; Region: Terminase_2; cl01513 216595008219 low GC region (40.21%) 216595008220 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 216595008221 RHS Repeat; Region: RHS_repeat; cl11982 216595008222 RHS Repeat; Region: RHS_repeat; cl11982 216595008223 RHS Repeat; Region: RHS_repeat; cl11982 216595008224 RHS Repeat; Region: RHS_repeat; cl11982 216595008225 RHS Repeat; Region: RHS_repeat; cl11982 216595008226 RHS protein; Region: RHS; pfam03527 216595008227 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 216595008241 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595008242 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595008243 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595008246 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 216595008247 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 216595008248 active site 216595008250 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 216595008251 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595008252 substrate binding pocket [chemical binding]; other site 216595008253 membrane-bound complex binding site; other site 216595008254 hinge residues; other site 216595008255 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 216595008256 N-acetyl-D-glucosamine binding site [chemical binding]; other site 216595008257 catalytic residue [active] 216595008259 DoxX; Region: DoxX; cl00976 216595008260 4 probable transmembrane helices predicted for PFLU1690 by TMHMM2.0 at aa 13-32, 47-69, 76-98 and 108-130 216595008262 ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility and secretion]; Region: GldG; COG3225 216595008263 gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521 216595008264 ABC-2 type transporter; Region: ABC2_membrane; cl11417 216595008265 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 216595008266 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595008267 Walker A/P-loop; other site 216595008268 ATP binding site [chemical binding]; other site 216595008269 Q-loop/lid; other site 216595008270 ABC transporter signature motif; other site 216595008271 Walker B; other site 216595008272 D-loop; other site 216595008273 H-loop/switch region; other site 216595008275 phosphodiesterase; Provisional; Region: PRK12704 216595008276 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 216595008277 domain; Region: GreA_GreB_N; pfam03449 216595008278 C-term; Region: GreA_GreB; pfam01272 216595008281 PS00830 Prokaryotic transcription elongation factors signature 2. 216595008282 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 216595008284 PS00778 Histidine acid phosphatases active site signature. 216595008286 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 216595008287 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 216595008288 Walker A/P-loop; other site 216595008289 ATP binding site [chemical binding]; other site 216595008290 Q-loop/lid; other site 216595008291 ABC transporter signature motif; other site 216595008292 Walker B; other site 216595008293 D-loop; other site 216595008294 H-loop/switch region; other site 216595008296 PS00211 ABC transporters family signature. 216595008297 PS00017 ATP/GTP-binding site motif A (P-loop). 216595008298 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 216595008299 active site 216595008300 catalytic triad [active] 216595008301 oxyanion hole [active] 216595008302 switch loop; other site 216595008304 PS01098 Lipolytic enzymes G-D-S-L family, serine active site. 216595008305 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 216595008306 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 216595008308 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595008309 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 216595008310 NeuB family; Region: NeuB; cl00496 216595008311 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 216595008313 PilZ domain; Region: PilZ; cl01260 216595008314 2-dehydropantoate 2-reductase; Provisional; Region: PRK06249 216595008315 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595008316 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 216595008318 1 probable transmembrane helix predicted for PFLU1707 by TMHMM2.0 at aa 13-32 216595008320 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 216595008322 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216595008323 Ligand Binding Site [chemical binding]; other site 216595008325 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 216595008326 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595008327 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 216595008328 substrate binding site [chemical binding]; other site 216595008329 dimerization interface [polypeptide binding]; other site 216595008331 PS00044 Bacterial regulatory proteins, lysR family signature. 216595008333 C-term; Region: GreA_GreB; pfam01272 216595008334 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 216595008335 1 probable transmembrane helix predicted for PFLU1712 by TMHMM2.0 at aa 42-64 216595008336 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; cl01823 216595008337 elongation factor P; Validated; Region: PRK00529 216595008338 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 216595008339 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 216595008340 RNA binding site [nucleotide binding]; other site 216595008341 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 216595008345 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595008346 Chlorophyllase; Region: Chlorophyllase; cl15281 216595008347 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 216595008348 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595008350 OsmC-like protein; Region: OsmC; cl00767 216595008352 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595008354 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595008355 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595008356 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 216595008357 putative effector binding pocket; other site 216595008358 dimerization interface [polypeptide binding]; other site 216595008361 PS00044 Bacterial regulatory proteins, lysR family signature. 216595008362 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 216595008364 8 probable transmembrane helices predicted for PFLU1719 by TMHMM2.0 at aa 7-29, 44-61, 74-93, 97-116, 136-158, 173-195, 202-219 and 229-247 216595008365 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595008366 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595008367 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595008368 dimerization interface [polypeptide binding]; other site 216595008371 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 216595008373 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 216595008374 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 216595008376 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 216595008378 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595008379 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 216595008380 enoyl-CoA hydratase; Provisional; Region: PRK06563 216595008381 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 216595008382 substrate binding site [chemical binding]; other site 216595008383 oxyanion hole (OAH) forming residues; other site 216595008384 trimer interface [polypeptide binding]; other site 216595008386 helicase 45; Provisional; Region: PTZ00424 216595008387 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 216595008388 ATP binding site [chemical binding]; other site 216595008389 Mg++ binding site [ion binding]; other site 216595008390 motif III; other site 216595008391 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216595008392 nucleotide binding region [chemical binding]; other site 216595008393 ATP-binding site [chemical binding]; other site 216595008394 DbpA RNA binding domain; Region: DbpA; pfam03880 216595008396 PS00017 ATP/GTP-binding site motif A (P-loop). 216595008397 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 216595008400 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 216595008401 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 216595008402 putative active site [active] 216595008403 metal binding site [ion binding]; metal-binding site 216595008405 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 216595008408 Peptidase family M48; Region: Peptidase_M48; cl12018 216595008411 tyrosine aminotransferase, eukaryotic; Region: tyr_amTase_E; TIGR01264 216595008412 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216595008413 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595008414 homodimer interface [polypeptide binding]; other site 216595008415 catalytic residue [active] 216595008417 SelR domain; Region: SelR; cl00369 216595008419 Transposase; Region: DEDD_Tnp_IS110; pfam01548 216595008420 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 216595008423 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340 216595008424 catalytic residues [active] 216595008425 dimer interface [polypeptide binding]; other site 216595008427 PS00460 Glutathione peroxidases selenocysteine active site. 216595008428 PS00763 Glutathione peroxidases signature 2. 216595008429 Transcriptional regulators [Transcription]; Region: MarR; COG1846 216595008430 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595008432 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 216595008433 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595008434 dimer interface [polypeptide binding]; other site 216595008435 phosphorylation site [posttranslational modification] 216595008436 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595008437 ATP binding site [chemical binding]; other site 216595008438 Mg2+ binding site [ion binding]; other site 216595008439 G-X-G motif; other site 216595008440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595008441 active site 216595008442 phosphorylation site [posttranslational modification] 216595008443 intermolecular recognition site; other site 216595008444 dimerization interface [polypeptide binding]; other site 216595008448 1 probable transmembrane helix predicted for PFLU1736 by TMHMM2.0 at aa 203-225 216595008449 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 216595008450 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595008451 Walker A motif; other site 216595008452 ATP binding site [chemical binding]; other site 216595008453 Walker B motif; other site 216595008454 PS00017 ATP/GTP-binding site motif A (P-loop). 216595008456 GAF domain; Region: GAF; cl00853 216595008458 PS01320 Uncharacterized protein family UPF0067 signature. 216595008459 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 216595008460 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595008461 substrate binding pocket [chemical binding]; other site 216595008462 membrane-bound complex binding site; other site 216595008463 hinge residues; other site 216595008464 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595008465 substrate binding pocket [chemical binding]; other site 216595008466 membrane-bound complex binding site; other site 216595008467 hinge residues; other site 216595008468 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 216595008469 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595008470 dimer interface [polypeptide binding]; other site 216595008471 phosphorylation site [posttranslational modification] 216595008472 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595008473 ATP binding site [chemical binding]; other site 216595008474 Mg2+ binding site [ion binding]; other site 216595008475 G-X-G motif; other site 216595008476 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595008477 active site 216595008478 phosphorylation site [posttranslational modification] 216595008479 intermolecular recognition site; other site 216595008480 dimerization interface [polypeptide binding]; other site 216595008481 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 216595008487 1 probable transmembrane helix predicted for PFLU1739 by TMHMM2.0 at aa 545-567 216595008489 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216595008490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595008491 active site 216595008492 phosphorylation site [posttranslational modification] 216595008493 intermolecular recognition site; other site 216595008494 dimerization interface [polypeptide binding]; other site 216595008495 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 216595008496 DNA binding residues [nucleotide binding] 216595008497 dimerization interface [polypeptide binding]; other site 216595008499 PS00622 Bacterial regulatory proteins, luxR family signature. 216595008501 Response regulator receiver domain; Region: Response_reg; pfam00072 216595008502 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595008503 active site 216595008504 phosphorylation site [posttranslational modification] 216595008505 intermolecular recognition site; other site 216595008506 dimerization interface [polypeptide binding]; other site 216595008508 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 216595008509 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 216595008511 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216595008512 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 216595008514 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 216595008515 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 216595008517 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 216595008519 11 probable transmembrane helices predicted for PFLU1747 by TMHMM2.0 at aa 31-50, 63-85, 105-127, 134-156, 176-198, 210-232, 247-269, 274-293, 297-314, 326-348 and 363-385 216595008520 PS01219 Ammonium transporters signature. 216595008521 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 216595008522 putative cation:proton antiport protein; Provisional; Region: PRK10669 216595008523 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595008526 PS00041 Bacterial regulatory proteins, araC family signature. 216595008527 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 216595008529 PS00017 ATP/GTP-binding site motif A (P-loop). 216595008530 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 216595008531 PSRA_1: Pseudouridine synthase, a subgroup of the RluA family. This group is comprised of bacterial proteins assigned to the RluA family of pseudouridine synthases. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PSRA_1; cd02558 216595008532 probable active site [active] 216595008534 PS01129 Rlu family of pseudouridine synthase signature. 216595008535 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 216595008537 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595008538 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 216595008539 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 216595008540 GTP binding site [chemical binding]; other site 216595008541 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886 216595008542 MPT binding site; other site 216595008543 trimer interface [polypeptide binding]; other site 216595008545 PS01078 Molybdenum cofactor biosynthesis proteins signature 1. 216595008546 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 216595008547 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 216595008548 dimer interface [polypeptide binding]; other site 216595008549 putative functional site; other site 216595008550 putative MPT binding site; other site 216595008553 PS01079 Molybdenum cofactor biosynthesis proteins signature 2. 216595008555 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017 216595008557 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 216595008558 PS00017 ATP/GTP-binding site motif A (P-loop). 216595008559 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 216595008560 CcmA, the ATP-binding component of the bacterial CcmAB transporter. The CCM family is involved in bacterial cytochrome c biogenesis. Cytochrome c maturation in E. coli requires the ccm operon, which encodes eight membrane proteins (CcmABCDEFGH); Region: ABC_CcmA_heme_exporter; cd03231 216595008561 Walker A/P-loop; other site 216595008562 ATP binding site [chemical binding]; other site 216595008563 Q-loop/lid; other site 216595008564 ABC transporter signature motif; other site 216595008565 Walker B; other site 216595008566 D-loop; other site 216595008567 H-loop/switch region; other site 216595008569 PS00017 ATP/GTP-binding site motif A (P-loop). 216595008570 PS00211 ABC transporters family signature. 216595008571 CcmB protein; Region: CcmB; cl01016 216595008573 6 probable transmembrane helices predicted for PFLU1759 by TMHMM2.0 at aa 23-45, 52-74, 101-123, 130-152, 162-184 and 197-219 216595008574 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 216595008576 6 probable transmembrane helices predicted for PFLU1760 by TMHMM2.0 at aa 34-56, 71-93, 105-127, 142-164, 171-193 and 213-235 216595008577 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595008578 Heme exporter protein D (CcmD); Region: CcmD; cl11475 216595008580 1 probable transmembrane helix predicted for PFLU1761 by TMHMM2.0 at aa 18-40 216595008581 CcmE; Region: CcmE; cl00994 216595008583 1 probable transmembrane helix predicted for PFLU1762 by TMHMM2.0 at aa 9-31 216595008584 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 216595008585 15 probable transmembrane helices predicted for PFLU1763 by TMHMM2.0 at aa 15-34, 46-68, 96-118, 125-147, 181-203, 216-238, 253-270, 282-304, 319-337, 358-380, 395-417, 426-448, 452-471, 492-514 and 620-639 216595008587 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 216595008588 catalytic residues [active] 216595008589 central insert; other site 216595008590 1 probable transmembrane helix predicted for PFLU1764 by TMHMM2.0 at aa 7-26 216595008592 Cytochrome C biogenesis protein; Region: CcmH; cl01179 216595008594 2 probable transmembrane helices predicted for PFLU1765 by TMHMM2.0 at aa 5-22 and 103-125 216595008595 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 216595008596 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 216595008597 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 216595008598 binding surface 216595008599 TPR motif; other site 216595008600 2 probable transmembrane helices predicted for PFLU1766 by TMHMM2.0 at aa 4-26 and 94-116 216595008603 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595008604 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216595008605 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595008606 putative substrate translocation pore; other site 216595008607 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595008609 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 216595008610 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595008612 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 216595008613 Glutamine amidotransferase class-I; Region: GATase; pfam00117 216595008614 glutamine binding [chemical binding]; other site 216595008615 catalytic triad [active] 216595008616 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 216595008617 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 216595008618 chorismate binding enzyme; Region: Chorismate_bind; cl10555 216595008622 PS00442 Glutamine amidotransferases class-I active site. 216595008623 Chorismate mutase type II; Region: CM_2; cl00693 216595008625 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 216595008626 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 216595008627 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216595008628 catalytic residue [active] 216595008630 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 216595008631 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 216595008632 S-adenosylmethionine binding site [chemical binding]; other site 216595008634 PS00092 N-6 Adenine-specific DNA methylases signature. 216595008635 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 216595008638 PS00175 Phosphoglycerate mutase family phosphohistidine signature. 216595008639 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 216595008640 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256 216595008641 Walker A/P-loop; other site 216595008642 ATP binding site [chemical binding]; other site 216595008643 Q-loop/lid; other site 216595008644 ABC transporter signature motif; other site 216595008645 Walker B; other site 216595008646 D-loop; other site 216595008647 H-loop/switch region; other site 216595008649 PS00017 ATP/GTP-binding site motif A (P-loop). 216595008650 PS00211 ABC transporters family signature. 216595008651 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 216595008652 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595008653 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 216595008654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595008655 dimer interface [polypeptide binding]; other site 216595008656 conserved gate region; other site 216595008657 ABC-ATPase subunit interface; other site 216595008658 6 probable transmembrane helices predicted for PFLU1779 by TMHMM2.0 at aa 13-32, 71-93, 122-144, 180-197, 204-226 and 230-252 216595008660 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 216595008661 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595008662 DNA-binding site [nucleotide binding]; DNA binding site 216595008663 UTRA domain; Region: UTRA; cl01230 216595008665 PS00043 Bacterial regulatory proteins, gntR family signature. 216595008667 Phosphonate metabolism protein PhnG; Region: PhnG; cl01454 216595008669 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; cl01455 216595008671 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; cl01456 216595008673 Phosphonate metabolism protein PhnJ; Region: PhnJ; cl01457 216595008675 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 216595008676 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 216595008677 Walker A/P-loop; other site 216595008678 ATP binding site [chemical binding]; other site 216595008679 Q-loop/lid; other site 216595008680 ABC transporter signature motif; other site 216595008681 Walker B; other site 216595008682 D-loop; other site 216595008683 H-loop/switch region; other site 216595008684 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216595008686 PS00017 ATP/GTP-binding site motif A (P-loop). 216595008687 PS00211 ABC transporters family signature. 216595008689 phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324 216595008690 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595008691 Walker A/P-loop; other site 216595008692 ATP binding site [chemical binding]; other site 216595008693 Q-loop/lid; other site 216595008694 ABC transporter signature motif; other site 216595008695 Walker B; other site 216595008696 D-loop; other site 216595008697 H-loop/switch region; other site 216595008699 PS00017 ATP/GTP-binding site motif A (P-loop). 216595008700 PS00211 ABC transporters family signature. 216595008701 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 216595008702 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 216595008703 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 216595008704 active site 216595008706 PS00190 Cytochrome c family heme-binding site signature. 216595008707 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595008708 Active site [active] 216595008709 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 216595008710 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 216595008712 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595008713 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595008714 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 216595008715 putative effector binding pocket; other site 216595008716 dimerization interface [polypeptide binding]; other site 216595008719 YcfA-like protein; Region: YcfA; cl00752 216595008721 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 216595008723 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 216595008724 active site 216595008725 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 216595008727 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 216595008731 1 probable transmembrane helix predicted for PFLU1793 by TMHMM2.0 at aa 475-497 216595008732 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 216595008733 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595008734 putative substrate translocation pore; other site 216595008736 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595008738 Ion transport protein; Region: Ion_trans; pfam00520 216595008739 Ion channel; Region: Ion_trans_2; cl11596 216595008741 Urea transporter; Region: UT; cl01829 216595008743 pyruvate kinase; Provisional; Region: PRK06247 216595008744 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 216595008745 domain interfaces; other site 216595008746 active site 216595008749 PS00110 Pyruvate kinase active site signature. 216595008750 MOFRL family; Region: MOFRL; cl01013 216595008752 tartronate semialdehyde reductase; Provisional; Region: PRK15059 216595008753 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595008755 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 216595008757 glyoxylate carboligase; Provisional; Region: PRK11269 216595008758 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 216595008759 PYR/PP interface [polypeptide binding]; other site 216595008760 dimer interface [polypeptide binding]; other site 216595008761 TPP binding site [chemical binding]; other site 216595008762 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 216595008763 TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the condensation of two molecules of glyoxylate to give...; Region: TPP_Gcl; cd02006 216595008764 TPP-binding site [chemical binding]; other site 216595008768 Domain of unknown function (DUF336); Region: DUF336; cl01249 216595008770 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 216595008771 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216595008772 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 216595008775 Protein of unknown function (DUF808); Region: DUF808; cl01002 216595008777 4 probable transmembrane helices predicted for PFLU1806 by TMHMM2.0 at aa 91-113, 195-217, 252-274 and 294-316 216595008778 VacJ like lipoprotein; Region: VacJ; cl01073 216595008780 3 probable transmembrane helices predicted for PFLU1810 by TMHMM2.0 at aa 7-29, 61-83 and 90-112 216595008781 Glycosyl hydrolases family 17; Region: Glyco_hydro_17; cl02191 216595008783 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 216595008784 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 216595008786 Protein of unknown function, DUF485; Region: DUF485; cl01231 216595008788 2 probable transmembrane helices predicted for PFLU1813 by TMHMM2.0 at aa 24-46 and 61-83 216595008789 Sodium:solute symporter family; Region: SSF; cl00456 216595008790 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 216595008791 14 probable transmembrane helices predicted for PFLU1814 by TMHMM2.0 at aa 5-24, 34-56, 77-99, 105-127, 148-170, 185-204, 211-228, 266-288, 301-323, 364-386, 407-426, 431-453, 465-487 and 497-519 216595008793 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 216595008794 dimer interface [polypeptide binding]; other site 216595008795 Citrate synthase; Region: Citrate_synt; pfam00285 216595008796 active site 216595008797 citrylCoA binding site [chemical binding]; other site 216595008798 NADH binding [chemical binding]; other site 216595008799 cationic pore residues; other site 216595008800 oxalacetate/citrate binding site [chemical binding]; other site 216595008801 coenzyme A binding site [chemical binding]; other site 216595008802 catalytic triad [active] 216595008804 PS00480 Citrate synthase signature. 216595008805 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 216595008806 Iron-sulfur protein interface; other site 216595008807 proximal quinone binding site [chemical binding]; other site 216595008808 SdhD (CybS) interface [polypeptide binding]; other site 216595008809 proximal heme binding site [chemical binding]; other site 216595008811 PS01000 Succinate dehydrogenase cytochrome b subunit signature 1. 216595008812 3 probable transmembrane helices predicted for PFLU1816 by TMHMM2.0 at aa 21-43, 68-90 and 103-123 216595008813 PS01001 Succinate dehydrogenase cytochrome b subunit signature 2. 216595008814 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 216595008815 SdhC subunit interface [polypeptide binding]; other site 216595008816 proximal heme binding site [chemical binding]; other site 216595008817 cardiolipin binding site; other site 216595008818 Iron-sulfur protein interface; other site 216595008819 proximal quinone binding site [chemical binding]; other site 216595008820 3 probable transmembrane helices predicted for PFLU1817 by TMHMM2.0 at aa 25-47, 57-79 and 100-122 216595008821 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05675 216595008822 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595008823 domain; Region: Succ_DH_flav_C; pfam02910 216595008825 PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site. 216595008827 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 216595008828 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216595008829 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 216595008830 TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of...; Region: TPP_E1_OGDC_like; cd02016 216595008831 TPP-binding site [chemical binding]; other site 216595008832 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 216595008835 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 216595008836 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 216595008837 E3 interaction surface; other site 216595008838 lipoyl attachment site [posttranslational modification]; other site 216595008839 e3 binding domain; Region: E3_binding; pfam02817 216595008840 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 216595008842 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 216595008845 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 216595008846 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595008847 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595008848 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 216595008850 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 216595008853 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 216595008854 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 216595008855 CoA-ligase; Region: Ligase_CoA; pfam00549 216595008858 PS01217 ATP-citrate lyase / succinyl-CoA ligases family signature 3. 216595008859 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 216595008860 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595008861 CoA-ligase; Region: Ligase_CoA; pfam00549 216595008864 PS01216 ATP-citrate lyase / succinyl-CoA ligases family signature 1. 216595008865 PS00399 ATP-citrate lyase / succinyl-CoA ligases family active site. 216595008867 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 216595008869 12 probable transmembrane helices predicted for PFLU1825 by TMHMM2.0 at aa 82-104, 114-136, 149-171, 191-213, 220-242, 262-284, 297-319, 348-370, 377-399, 409-431, 444-466 and 481-498 216595008870 Protein of unknown function, DUF599; Region: DUF599; cl01575 216595008871 4 probable transmembrane helices predicted for PFLU1826 by TMHMM2.0 at aa 29-51, 93-115, 136-158 and 215-237 216595008873 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595008874 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 216595008875 CoenzymeA binding site [chemical binding]; other site 216595008876 subunit interaction site [polypeptide binding]; other site 216595008877 PHB binding site; other site 216595008879 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 216595008880 CoenzymeA binding site [chemical binding]; other site 216595008881 subunit interaction site [polypeptide binding]; other site 216595008882 PHB binding site; other site 216595008884 heat shock protein 90; Provisional; Region: PRK05218 216595008885 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 216595008886 PS00298 Heat shock hsp90 proteins family signature. 216595008889 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 216595008890 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595008892 Pirin-related protein [General function prediction only]; Region: COG1741 216595008893 Cupin domain; Region: Cupin_2; cl09118 216595008894 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 216595008897 OsmC-like protein; Region: OsmC; cl00767 216595008899 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 216595008901 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 216595008902 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 216595008903 dimer interface [polypeptide binding]; other site 216595008904 active site 216595008906 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 216595008908 PS00606 Beta-ketoacyl synthases active site. 216595008909 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595008910 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 216595008911 active site 1 [active] 216595008912 dimer interface [polypeptide binding]; other site 216595008913 active site 2 [active] 216595008915 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595008916 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595008917 dimer interface [polypeptide binding]; other site 216595008918 phosphorylation site [posttranslational modification] 216595008919 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595008920 ATP binding site [chemical binding]; other site 216595008921 Mg2+ binding site [ion binding]; other site 216595008922 G-X-G motif; other site 216595008923 Response regulator receiver domain; Region: Response_reg; pfam00072 216595008924 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595008925 active site 216595008926 phosphorylation site [posttranslational modification] 216595008927 intermolecular recognition site; other site 216595008928 dimerization interface [polypeptide binding]; other site 216595008933 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 216595008934 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 216595008935 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 216595008938 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 216595008939 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595008940 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 216595008943 1 probable transmembrane helix predicted for PFLU1841 by TMHMM2.0 at aa 25-47 216595008944 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 216595008945 catalytic core [active] 216595008947 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 216595008948 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595008950 PS00455 Putative AMP-binding domain signature. 216595008951 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 216595008952 CoenzymeA binding site [chemical binding]; other site 216595008953 subunit interaction site [polypeptide binding]; other site 216595008954 PHB binding site; other site 216595008956 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216595008958 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216595008960 Domain of unknown function DUF20; Region: UPF0118; cl00465 216595008961 8 probable transmembrane helices predicted for PFLU1848 by TMHMM2.0 at aa 7-26, 31-53, 58-80, 149-171, 208-230, 235-257, 269-286 and 301-323 216595008963 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595008964 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 216595008965 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595008966 ATP binding site [chemical binding]; other site 216595008967 Mg2+ binding site [ion binding]; other site 216595008968 G-X-G motif; other site 216595008972 osmolarity response regulator; Provisional; Region: ompR; PRK09468 216595008973 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595008974 active site 216595008975 phosphorylation site [posttranslational modification] 216595008976 intermolecular recognition site; other site 216595008977 dimerization interface [polypeptide binding]; other site 216595008978 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 216595008979 DNA binding site [nucleotide binding] 216595008982 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 216595008983 active site 216595008984 dimer interface [polypeptide binding]; other site 216595008986 PS00156 Orotidine 5'-phosphate decarboxylase active site. 216595008987 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 216595008988 Prostaglandin dehydrogenases; Region: PGDH; cd05288 216595008989 NAD(P) binding site [chemical binding]; other site 216595008990 substrate binding site [chemical binding]; other site 216595008991 dimer interface [polypeptide binding]; other site 216595008993 PS00017 ATP/GTP-binding site motif A (P-loop). 216595008994 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 216595008995 classical (c) SDRs; Region: SDR_c; cd05233 216595008996 NAD(P) binding site [chemical binding]; other site 216595008997 active site 216595008999 PS00061 Short-chain dehydrogenases/reductases family signature. 216595009000 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 216595009001 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595009002 DNA-binding site [nucleotide binding]; DNA binding site 216595009003 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216595009004 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595009005 homodimer interface [polypeptide binding]; other site 216595009006 catalytic residue [active] 216595009009 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 216595009010 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 216595009011 dimerization interface [polypeptide binding]; other site 216595009012 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595009013 2 probable transmembrane helices predicted for PFLU1855 by TMHMM2.0 at aa 41-63 and 326-348 216595009016 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216595009017 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595009019 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 216595009020 1 probable transmembrane helix predicted for PFLU1858 by TMHMM2.0 at aa 4-26 216595009021 hypothetical protein; Provisional; Region: PRK06156 216595009022 M28, and M42; Region: Zinc_peptidase_like; cl14876 216595009023 metal binding site [ion binding]; metal-binding site 216595009026 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 216595009027 1 probable transmembrane helix predicted for PFLU1859 by TMHMM2.0 at aa 7-29 216595009028 hypothetical protein; Provisional; Region: PRK06156 216595009029 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 216595009030 active site 216595009031 metal binding site [ion binding]; metal-binding site 216595009034 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 216595009035 PS00017 ATP/GTP-binding site motif A (P-loop). 216595009036 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 216595009037 alanine-tRNA ligase; Region: PLN02961 216595009038 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 216595009040 transcriptional activator TtdR; Provisional; Region: PRK09801 216595009041 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 216595009042 putative effector binding pocket; other site 216595009043 dimerization interface [polypeptide binding]; other site 216595009046 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 216595009047 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 216595009048 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 216595009049 active site 216595009050 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 216595009054 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 216595009055 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 216595009056 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 216595009057 putative C-terminal domain interface [polypeptide binding]; other site 216595009058 putative GSH binding site (G-site) [chemical binding]; other site 216595009059 putative dimer interface [polypeptide binding]; other site 216595009060 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 216595009061 putative N-terminal domain interface [polypeptide binding]; other site 216595009062 putative dimer interface [polypeptide binding]; other site 216595009063 putative substrate binding pocket (H-site) [chemical binding]; other site 216595009066 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 216595009067 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595009068 Walker A/P-loop; other site 216595009069 ATP binding site [chemical binding]; other site 216595009070 Q-loop/lid; other site 216595009071 ABC transporter signature motif; other site 216595009072 Walker B; other site 216595009073 D-loop; other site 216595009074 H-loop/switch region; other site 216595009076 PS00017 ATP/GTP-binding site motif A (P-loop). 216595009077 PS00211 ABC transporters family signature. 216595009078 ABC-2 type transporter; Region: ABC2_membrane; cl11417 216595009080 6 probable transmembrane helices predicted for PFLU1869 by TMHMM2.0 at aa 31-50, 65-87, 108-130, 145-167, 174-196 and 231-253 216595009081 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216595009083 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595009084 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216595009085 12 probable transmembrane helices predicted for PFLU1871 by TMHMM2.0 at aa 12-34, 44-66, 78-95, 105-125, 132-154, 164-181, 210-232, 245-267, 274-293, 298-320, 333-355 and 370-387 216595009087 PS00216 Sugar transport proteins signature 1. 216595009088 Cupin domain; Region: Cupin_2; cl09118 216595009090 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318 216595009091 C4-dicarboxylate transporter/malic acid transport protein; Region: C4dic_mal_tran; pfam03595 216595009092 gating phenylalanine in ion channel; other site 216595009093 10 probable transmembrane helices predicted for PFLU1873 by TMHMM2.0 at aa 27-49, 59-81, 94-116, 131-153, 166-188, 198-220, 233-255, 275-297, 309-326 and 336-358 216595009095 H+ Antiporter protein; Region: 2A0121; TIGR00900 216595009096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595009097 putative substrate translocation pore; other site 216595009098 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 216595009099 putative acyl-acceptor binding pocket; other site 216595009101 11 probable transmembrane helices predicted for PFLU1874 by TMHMM2.0 at aa 52-71, 83-105, 110-132, 145-167, 172-191, 232-254, 264-286, 293-315, 338-360, 373-395 and 405-424 216595009103 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 216595009105 Membrane transport protein; Region: Mem_trans; cl09117 216595009106 bile acid transporter; Region: bass; TIGR00841 216595009109 Putative exonuclease, RdgC; Region: RdgC; cl01122 216595009111 1/3 vs 2/3 216595009112 PFI-5 216595009113 integrase; Provisional; Region: PRK09692 216595009114 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 216595009115 active site 216595009116 Int/Topo IB signature motif; other site 216595009118 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 216595009119 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 216595009120 putative active site [active] 216595009121 putative metal binding site [ion binding]; other site 216595009122 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 216595009124 Predicted GTPase [General function prediction only]; Region: Obg; COG0536 216595009125 PS00017 ATP/GTP-binding site motif A (P-loop). 216595009126 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 216595009128 PS00216 Sugar transport proteins signature 1. 216595009129 Integrase core domain; Region: rve; cl01316 216595009131 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 216595009132 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595009133 Walker A motif; other site 216595009134 ATP binding site [chemical binding]; other site 216595009135 Walker B motif; other site 216595009136 arginine finger; other site 216595009138 PS00017 ATP/GTP-binding site motif A (P-loop). 216595009139 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 216595009140 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 216595009143 PS00017 ATP/GTP-binding site motif A (P-loop). 216595009144 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 216595009145 Cytochrome c; Region: Cytochrom_C; cl11414 216595009146 Cytochrome c; Region: Cytochrom_C; cl11414 216595009148 PS00190 Cytochrome c family heme-binding site signature. 216595009149 PS00190 Cytochrome c family heme-binding site signature. 216595009151 PS00190 Cytochrome c family heme-binding site signature. 216595009152 1 probable transmembrane helix predicted for PFLU1891 by TMHMM2.0 at aa 13-35 216595009153 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily...; Region: Heme_Cu_Oxidase_I; cl00275 216595009154 Low-spin heme binding site [chemical binding]; other site 216595009155 D-pathway; other site 216595009156 Putative water exit pathway; other site 216595009157 Binuclear center (active site) [active] 216595009158 K-pathway; other site 216595009159 Putative proton exit pathway; other site 216595009161 Cytochrome c; Region: Cytochrom_C; cl11414 216595009163 PS00190 Cytochrome c family heme-binding site signature. 216595009164 1 probable transmembrane helix predicted for PFLU1893 by TMHMM2.0 at aa 15-37 216595009165 PS00190 Cytochrome c family heme-binding site signature. 216595009166 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 216595009167 Moco binding site; other site 216595009168 metal coordination site [ion binding]; other site 216595009171 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 216595009172 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 216595009173 structural tetrad; other site 216595009174 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 216595009175 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595009176 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 216595009177 putative dimerization interface [polypeptide binding]; other site 216595009180 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318 216595009181 C4-dicarboxylate transporter/malic acid transport protein; Region: C4dic_mal_tran; pfam03595 216595009182 gating phenylalanine in ion channel; other site 216595009184 10 probable transmembrane helices predicted for PFLU1898 by TMHMM2.0 at aa 32-54, 64-86, 98-120, 135-157, 170-192, 202-224, 237-259, 279-301, 313-330 and 340-362 216595009185 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035 216595009186 putative uracil binding site [chemical binding]; other site 216595009187 putative active site [active] 216595009188 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 216595009190 9 probable transmembrane helices predicted for PFLU1900 by TMHMM2.0 at aa 28-50, 62-84, 104-126, 133-155, 194-216, 223-245, 330-352, 365-387 and 414-436 216595009191 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 216595009192 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 216595009193 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 216595009195 8 probable transmembrane helices predicted for PFLU1901 by TMHMM2.0 at aa 7-26, 74-96, 117-139, 159-181, 194-216, 231-253, 260-282 and 302-324 216595009196 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 216595009197 dimer interface [polypeptide binding]; other site 216595009198 substrate binding site [chemical binding]; other site 216595009199 metal binding sites [ion binding]; metal-binding site 216595009201 PS00387 Inorganic pyrophosphatase signature. 216595009202 enolase; Provisional; Region: eno; PRK00077 216595009203 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 216595009204 dimer interface [polypeptide binding]; other site 216595009205 metal binding site [ion binding]; metal-binding site 216595009206 substrate binding pocket [chemical binding]; other site 216595009208 PS00164 Enolase signature. 216595009210 1 probable transmembrane helix predicted for PFLU1905 by TMHMM2.0 at aa 21-40 216595009211 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 216595009212 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 216595009213 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 216595009214 putative Cl- selectivity filter; other site 216595009215 putative pore gating glutamate residue; other site 216595009217 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 216595009219 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 216595009221 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 216595009222 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 216595009223 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 216595009225 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 216595009226 putative active site [active] 216595009227 putative NTP binding site [chemical binding]; other site 216595009228 putative nucleic acid binding site [nucleotide binding]; other site 216595009229 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595009230 Walker A/P-loop; other site 216595009231 ATP binding site [chemical binding]; other site 216595009232 PS00017 ATP/GTP-binding site motif A (P-loop). 216595009233 PS00017 ATP/GTP-binding site motif A (P-loop). 216595009234 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 216595009235 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 216595009238 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 216595009239 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 216595009241 1 probable transmembrane helix predicted for PFLU1919 by TMHMM2.0 at aa 64-86 216595009242 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 216595009243 PS00017 ATP/GTP-binding site motif A (P-loop). 216595009244 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 216595009245 TraU protein; Region: TraU; cl06067 216595009247 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216595009248 non-specific DNA binding site [nucleotide binding]; other site 216595009249 salt bridge; other site 216595009250 sequence-specific DNA binding site [nucleotide binding]; other site 216595009252 PS00045 Bacterial histone-like DNA-binding proteins signature. 216595009253 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 216595009254 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595009255 Walker A motif; other site 216595009256 ATP binding site [chemical binding]; other site 216595009257 Walker B motif; other site 216595009258 arginine finger; other site 216595009259 PS00017 ATP/GTP-binding site motif A (P-loop). 216595009260 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 216595009261 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595009262 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 216595009263 1 probable transmembrane helix predicted for PFLU1929 by TMHMM2.0 at aa 23-45 216595009264 Protein of unknown function (DUF3438); Region: DUF3438; cl13372 216595009265 Protein of unknown function (DUF2895); Region: DUF2895; cl12968 216595009266 1 probable transmembrane helix predicted for PFLU1931 by TMHMM2.0 at aa 20-39 216595009267 Protein of unknown function (DUF3487); Region: DUF3487; cl13432 216595009268 Protein of unknown function (DUF2976); Region: DUF2976; cl12739 216595009269 Protein of unknown function (DUF3262); Region: DUF3262; cl13160 216595009270 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; cl09893 216595009271 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216595009272 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 216595009273 tetramerization interface [polypeptide binding]; other site 216595009274 NAD(P) binding site [chemical binding]; other site 216595009275 catalytic residues [active] 216595009277 PS00070 Aldehyde dehydrogenases cysteine active site. 216595009278 PS00687 Aldehyde dehydrogenases glutamic acid active site. 216595009279 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 216595009280 dimer interface [polypeptide binding]; other site 216595009281 catalytic residue [active] 216595009283 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595009284 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 216595009285 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595009287 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216595009288 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595009289 DNA-binding site [nucleotide binding]; DNA binding site 216595009290 FCD domain; Region: FCD; cl11656 216595009293 hypothetical protein; Provisional; Region: PRK06847 216595009294 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595009295 PS00216 Sugar transport proteins signature 1. 216595009297 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216595009298 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595009299 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467 216595009300 iron-sulfur cluster [ion binding]; other site 216595009301 [2Fe-2S] cluster binding site [ion binding]; other site 216595009303 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 216595009304 putative active site [active] 216595009305 putative metal binding site [ion binding]; other site 216595009307 PS00934 Glyoxalase I signature 1. 216595009308 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595009309 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595009310 The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462 216595009311 putative substrate binding pocket [chemical binding]; other site 216595009312 putative dimerization interface [polypeptide binding]; other site 216595009315 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 216595009317 E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572 216595009318 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 216595009319 NAD binding site [chemical binding]; other site 216595009320 dimerization interface [polypeptide binding]; other site 216595009321 product binding site; other site 216595009322 substrate binding site [chemical binding]; other site 216595009323 zinc binding site [ion binding]; other site 216595009324 catalytic residues [active] 216595009326 classical (c) SDRs; Region: SDR_c; cd05233 216595009327 NAD(P) binding site [chemical binding]; other site 216595009328 active site 216595009330 PS00061 Short-chain dehydrogenases/reductases family signature. 216595009331 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 216595009332 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 216595009334 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216595009335 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595009336 NAD(P) binding site [chemical binding]; other site 216595009337 active site 216595009339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595009340 putative substrate translocation pore; other site 216595009341 12 probable transmembrane helices predicted for PFLU1953 by TMHMM2.0 at aa 13-35, 50-72, 84-103, 108-130, 142-164, 168-190, 211-233, 248-270, 277-299, 304-326, 339-361 and 366-388 216595009343 PS00216 Sugar transport proteins signature 1. 216595009344 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216595009345 classical (c) SDRs; Region: SDR_c; cd05233 216595009346 NAD(P) binding site [chemical binding]; other site 216595009347 active site 216595009348 PS00017 ATP/GTP-binding site motif A (P-loop). 216595009350 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 216595009353 1 probable transmembrane helix predicted for PFLU1956 by TMHMM2.0 at aa 9-31 216595009354 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216595009355 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595009356 DNA-binding site [nucleotide binding]; DNA binding site 216595009357 FCD domain; Region: FCD; cl11656 216595009361 integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747 216595009362 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 216595009363 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl14888 216595009364 PS00017 ATP/GTP-binding site motif A (P-loop). 216595009365 1 probable transmembrane helix predicted for PFLU1961 by TMHMM2.0 at aa 13-35 216595009366 Protein of unknown function (DUF2859); Region: DUF2859; cl12633 216595009368 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 216595009369 1 probable transmembrane helix predicted for PFLU1964 by TMHMM2.0 at aa 4-26 216595009370 1 probable transmembrane helix predicted for PFLU1965 by TMHMM2.0 at aa 4-26 216595009371 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595009372 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 216595009373 MPN+ (JAMM) motif; other site 216595009374 Zinc-binding site [ion binding]; other site 216595009376 PS01302 DNA repair protein radC family signature. 216595009377 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 216595009378 DNA topoisomerase III; Provisional; Region: PRK07726 216595009379 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by:...; Region: TOPRIM_TopoIA_TopoIII; cd03362 216595009380 active site 216595009381 putative interdomain interaction site [polypeptide binding]; other site 216595009382 putative metal-binding site [ion binding]; other site 216595009383 putative nucleotide binding site [chemical binding]; other site 216595009384 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 216595009385 domain I; other site 216595009386 DNA binding groove [nucleotide binding] 216595009387 phosphate binding site [ion binding]; other site 216595009388 domain II; other site 216595009389 domain III; other site 216595009390 nucleotide binding site [chemical binding]; other site 216595009391 catalytic site [active] 216595009392 domain IV; other site 216595009393 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 216595009397 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 216595009398 dimer interface [polypeptide binding]; other site 216595009399 ssDNA binding site [nucleotide binding]; other site 216595009400 tetramer (dimer of dimers) interface [polypeptide binding]; other site 216595009402 Protein of unknown function (DUF3158); Region: DUF3158; pfam11358 216595009403 Domain of unknown function (DUF1845); Region: DUF1845; cl07481 216595009405 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 216595009406 ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 216595009407 ParB-like nuclease domain; Region: ParBc; cl02129 216595009409 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 216595009410 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 216595009411 Magnesium ion binding site [ion binding]; other site 216595009413 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 216595009415 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 216595009416 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 216595009417 catalytic residues [active] 216595009419 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 216595009420 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as...; Region: OYE_like_FMN_family; cd02803 216595009421 active site 216595009422 FMN binding site [chemical binding]; other site 216595009423 substrate binding site [chemical binding]; other site 216595009424 putative catalytic residue [active] 216595009426 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595009427 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595009428 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 216595009429 putative effector binding pocket; other site 216595009430 dimerization interface [polypeptide binding]; other site 216595009433 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 216595009434 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 216595009435 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 216595009436 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 216595009439 PS00017 ATP/GTP-binding site motif A (P-loop). 216595009440 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216595009441 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595009442 NAD(P) binding site [chemical binding]; other site 216595009443 active site 216595009445 PS00061 Short-chain dehydrogenases/reductases family signature. 216595009446 1 probable transmembrane helix predicted for PFLU1988 by TMHMM2.0 at aa 21-40 216595009447 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216595009448 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595009449 NAD(P) binding site [chemical binding]; other site 216595009450 active site 216595009451 PS00017 ATP/GTP-binding site motif A (P-loop). 216595009453 PS00061 Short-chain dehydrogenases/reductases family signature. 216595009454 benzoate transport; Region: 2A0115; TIGR00895 216595009455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595009457 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595009458 PS00216 Sugar transport proteins signature 1. 216595009459 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 216595009460 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 216595009462 hypothetical protein; Provisional; Region: PRK06102 216595009463 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 216595009465 PS00017 ATP/GTP-binding site motif A (P-loop). 216595009466 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595009467 DNA-binding site [nucleotide binding]; DNA binding site 216595009468 Transcriptional regulators [Transcription]; Region: GntR; COG1802 216595009469 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595009470 DNA-binding site [nucleotide binding]; DNA binding site 216595009471 FCD domain; Region: FCD; cl11656 216595009473 PS00043 Bacterial regulatory proteins, gntR family signature. 216595009476 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595009477 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595009478 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 216595009479 putative substrate binding pocket [chemical binding]; other site 216595009480 dimerization interface [polypeptide binding]; other site 216595009483 PS00044 Bacterial regulatory proteins, lysR family signature. 216595009484 LamB/YcsF family; Region: LamB_YcsF; cl00664 216595009486 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 216595009487 carboxyltransferase (CT) interaction site; other site 216595009488 biotinylation site [posttranslational modification]; other site 216595009490 acetyl-CoA carboxylase biotin carboxylase subunit; Provisional; Region: PRK12833 216595009491 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 216595009492 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 216595009493 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 216595009496 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 216595009497 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 216595009499 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 216595009500 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 216595009502 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 216595009503 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 216595009505 Sodium:solute symporter family; Region: SSF; cl00456 216595009506 11 probable transmembrane helices predicted for PFLU2000 by TMHMM2.0 at aa 38-60, 65-87, 99-121, 136-158, 170-192, 207-229, 242-264, 279-301, 322-344, 354-376 and 389-411 216595009507 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216595009508 1 probable transmembrane helix predicted for PFLU2001 by TMHMM2.0 at aa 12-31 216595009509 PAS fold; Region: PAS_3; pfam08447 216595009510 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 216595009511 PAS fold; Region: PAS_3; pfam08447 216595009512 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 216595009517 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 216595009518 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants...; Region: Thr-synth_2; cd01560 216595009519 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595009520 catalytic residue [active] 216595009522 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 216595009523 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595009524 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595009525 PS00519 Bacterial regulatory proteins, asnC family signature. 216595009527 homoserine dehydrogenase; Provisional; Region: PRK06270 216595009528 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 216595009530 PS01042 Homoserine dehydrogenase signature. 216595009531 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216595009532 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 216595009533 NAD(P) binding site [chemical binding]; other site 216595009534 catalytic residues [active] 216595009536 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 216595009538 12 probable transmembrane helices predicted for PFLU2013 by TMHMM2.0 at aa 21-38, 42-64, 87-109, 129-151, 164-186, 206-228, 249-271, 275-297, 335-357, 367-389, 409-428 and 433-450 216595009539 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595009540 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595009541 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595009542 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595009543 dimerization interface [polypeptide binding]; other site 216595009546 PS00044 Bacterial regulatory proteins, lysR family signature. 216595009547 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 216595009548 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595009549 putative substrate translocation pore; other site 216595009550 12 probable transmembrane helices predicted for PFLU2015 by TMHMM2.0 at aa 23-40, 62-84, 97-119, 123-145, 152-174, 189-208, 249-271, 281-303, 315-334, 338-360, 373-395 and 405-427 216595009552 Uncharacterized conserved protein [Function unknown]; Region: COG5476 216595009553 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 216595009554 MlrC C-terminus; Region: MlrC_C; pfam07171 216595009557 PS00294 Prenyl group binding site (CAAX box). 216595009559 LysE type translocator; Region: LysE; cl00565 216595009560 5 probable transmembrane helices predicted for PFLU2019 by TMHMM2.0 at aa 23-45, 57-79, 89-111, 146-168 and 172-194 216595009562 BCCT family transporter; Region: BCCT; cl00569 216595009563 12 probable transmembrane helices predicted for PFLU2021 by TMHMM2.0 at aa 26-45, 65-87, 107-126, 157-179, 211-233, 248-267, 280-302, 332-351, 363-385, 417-439, 465-487 and 497-516 216595009565 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 216595009566 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595009567 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 216595009570 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 216595009571 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595009572 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595009573 dimerization interface [polypeptide binding]; other site 216595009575 PS00044 Bacterial regulatory proteins, lysR family signature. 216595009577 1 probable transmembrane helix predicted for PFLU2024 by TMHMM2.0 at aa 5-27 216595009578 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 216595009579 putative heme binding pocket [chemical binding]; other site 216595009580 1 probable transmembrane helix predicted for PFLU2025 by TMHMM2.0 at aa 27-49 216595009581 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 216595009582 PS00190 Cytochrome c family heme-binding site signature. 216595009584 PS00190 Cytochrome c family heme-binding site signature. 216595009585 1 probable transmembrane helix predicted for PFLU2026 by TMHMM2.0 at aa 26-48 216595009586 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 216595009587 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 216595009588 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 216595009589 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595009592 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 216595009593 PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2. 216595009594 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 216595009596 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216595009597 non-specific DNA binding site [nucleotide binding]; other site 216595009598 salt bridge; other site 216595009599 sequence-specific DNA binding site [nucleotide binding]; other site 216595009601 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216595009602 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 216595009603 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216595009604 metal binding site [ion binding]; metal-binding site 216595009605 active site 216595009606 I-site; other site 216595009610 carboxy-terminal protease; Provisional; Region: PRK11186 216595009611 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 216595009612 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 216595009613 protein binding site [polypeptide binding]; other site 216595009614 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 216595009615 Catalytic dyad [active] 216595009616 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 216595009619 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 216595009620 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 216595009621 NAD(P) binding site [chemical binding]; other site 216595009624 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 216595009625 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 216595009627 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 216595009628 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595009629 Walker A/P-loop; other site 216595009630 ATP binding site [chemical binding]; other site 216595009631 Q-loop/lid; other site 216595009632 ABC transporter signature motif; other site 216595009633 Walker B; other site 216595009634 D-loop; other site 216595009635 H-loop/switch region; other site 216595009636 TOBE domain; Region: TOBE_2; cl01440 216595009639 PS00211 ABC transporters family signature. 216595009640 PS00017 ATP/GTP-binding site motif A (P-loop). 216595009641 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 216595009642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 216595009644 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595009645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595009646 dimer interface [polypeptide binding]; other site 216595009647 conserved gate region; other site 216595009648 putative PBP binding loops; other site 216595009649 ABC-ATPase subunit interface; other site 216595009651 Sulfatase; Region: Sulfatase; cl10460 216595009653 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 216595009654 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595009655 transcriptional regulator protein; Region: phnR; TIGR03337 216595009656 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595009657 DNA-binding site [nucleotide binding]; DNA binding site 216595009658 UTRA domain; Region: UTRA; cl01230 216595009660 PS00043 Bacterial regulatory proteins, gntR family signature. 216595009662 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 216595009663 intersubunit interface [polypeptide binding]; other site 216595009665 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595009666 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 216595009667 ABC-ATPase subunit interface; other site 216595009668 dimer interface [polypeptide binding]; other site 216595009669 putative PBP binding regions; other site 216595009671 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 216595009672 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 216595009674 PS00211 ABC transporters family signature. 216595009675 PS00017 ATP/GTP-binding site motif A (P-loop). 216595009676 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 216595009677 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 216595009678 metal binding site [ion binding]; metal-binding site 216595009680 1 probable transmembrane helix predicted for PFLU2045 by TMHMM2.0 at aa 17-36 216595009681 1 probable transmembrane helix predicted for PFLU2047 by TMHMM2.0 at aa 21-40 216595009682 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 216595009683 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 216595009688 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 216595009689 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 216595009690 substrate binding site [chemical binding]; other site 216595009691 ligand binding site [chemical binding]; other site 216595009693 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595009694 PS00450 Aconitase family signature 1. 216595009695 PS01244 Aconitase family signature 2. 216595009696 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577 216595009697 substrate binding site [chemical binding]; other site 216595009700 transcriptional activator TtdR; Provisional; Region: PRK09801 216595009701 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595009702 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 216595009703 putative effector binding pocket; other site 216595009704 putative dimerization interface [polypeptide binding]; other site 216595009707 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216595009709 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 216595009710 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 216595009711 DNA binding residues [nucleotide binding] 216595009712 dimer interface [polypeptide binding]; other site 216595009713 [2Fe-2S] cluster binding site [ion binding]; other site 216595009716 PS00552 Bacterial regulatory proteins, merR family signature. 216595009717 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 216595009718 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595009719 Walker A motif; other site 216595009720 ATP binding site [chemical binding]; other site 216595009721 Walker B motif; other site 216595009722 arginine finger; other site 216595009723 PS00688 Sigma-54 interaction domain C-terminal part signature. 216595009725 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 216595009726 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 216595009727 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 216595009728 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 216595009729 Flavin binding site [chemical binding]; other site 216595009731 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 216595009732 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 216595009733 active site 216595009734 dimer interface [polypeptide binding]; other site 216595009735 non-prolyl cis peptide bond; other site 216595009736 insertion regions; other site 216595009738 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 216595009740 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 216595009741 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 216595009742 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216595009743 catalytic residue [active] 216595009745 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 216595009746 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595009747 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 216595009748 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 216595009749 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 216595009750 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline...; Region: APP; cd01085 216595009751 active site 216595009754 1 probable transmembrane helix predicted for PFLU2062 by TMHMM2.0 at aa 44-61 216595009755 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595009756 threonine and homoserine efflux system; Provisional; Region: PRK10532 216595009757 EamA-like transporter family; Region: EamA; cl01037 216595009759 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 216595009760 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 216595009761 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 216595009762 1 probable transmembrane helix predicted for PFLU2064 by TMHMM2.0 at aa 108-130 216595009764 PS00017 ATP/GTP-binding site motif A (P-loop). 216595009766 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 216595009768 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898 216595009769 putative hydrophobic ligand binding site [chemical binding]; other site 216595009771 PS00017 ATP/GTP-binding site motif A (P-loop). 216595009772 DNA polymerase II; Reviewed; Region: PRK05762 216595009773 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 216595009774 active site 216595009775 catalytic site [active] 216595009776 substrate binding site [chemical binding]; other site 216595009777 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 216595009778 active site 216595009779 metal-binding site 216595009782 PS00116 DNA polymerase family B signature. 216595009783 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 216595009785 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 216595009786 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_N_Beta; cd03057 216595009787 C-terminal domain interface [polypeptide binding]; other site 216595009788 GSH binding site (G-site) [chemical binding]; other site 216595009789 dimer interface [polypeptide binding]; other site 216595009790 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 216595009791 N-terminal domain interface [polypeptide binding]; other site 216595009792 dimer interface [polypeptide binding]; other site 216595009793 substrate binding pocket (H-site) [chemical binding]; other site 216595009795 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 216595009796 Acyltransferase family; Region: Acyl_transf_3; pfam01757 216595009798 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 216595009800 O-Antigen ligase; Region: Wzy_C; cl04850 216595009801 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 216595009803 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 216595009804 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 216595009806 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; cl10042 216595009808 1 probable transmembrane helix predicted for PFLU2076 by TMHMM2.0 at aa 7-24 216595009809 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216595009810 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 216595009812 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 216595009813 Chain length determinant protein; Region: Wzz; cl01623 216595009815 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 216595009816 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 216595009818 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595009819 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 216595009820 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 216595009821 active site 216595009823 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 216595009824 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 216595009825 Substrate binding site [chemical binding]; other site 216595009826 Cupin domain; Region: Cupin_2; cl09118 216595009829 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 216595009830 Bacterial sugar transferase; Region: Bac_transf; cl00939 216595009832 LysE type translocator; Region: LysE; cl00565 216595009833 6 probable transmembrane helices predicted for PFLU2084 by TMHMM2.0 at aa 38-60, 73-95, 105-122, 141-163, 178-200 and 213-235 216595009836 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 216595009837 conserved cys residue [active] 216595009839 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 216595009840 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 216595009841 conserved cys residue [active] 216595009844 PS00041 Bacterial regulatory proteins, araC family signature. 216595009846 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216595009847 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595009849 PS00340 Growth factor and cytokines receptors family signature 2. 216595009850 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 216595009851 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 216595009853 glucose-1-dehydrogenase; Provisional; Region: PRK08936 216595009854 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 216595009855 NAD binding site [chemical binding]; other site 216595009856 homodimer interface [polypeptide binding]; other site 216595009857 active site 216595009859 PS00061 Short-chain dehydrogenases/reductases family signature. 216595009860 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 216595009861 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 216595009862 motif II; other site 216595009864 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 216595009865 catalytic residue [active] 216595009866 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 216595009867 classical (c) SDRs; Region: SDR_c; cd05233 216595009868 NAD(P) binding site [chemical binding]; other site 216595009869 active site 216595009871 PS00017 ATP/GTP-binding site motif A (P-loop). 216595009872 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595009873 NAD(P) binding site [chemical binding]; other site 216595009874 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 216595009875 S-adenosylmethionine binding site [chemical binding]; other site 216595009877 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595009878 putative substrate translocation pore; other site 216595009879 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216595009880 11 probable transmembrane helices predicted for PFLU2096 by TMHMM2.0 at aa 20-42, 55-77, 106-128, 145-167, 171-193, 222-244, 259-281, 288-307, 312-334, 347-369 and 379-398 216595009882 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595009883 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation...; Region: APSK; cd02027 216595009884 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 216595009885 ligand-binding site [chemical binding]; other site 216595009887 PS00017 ATP/GTP-binding site motif A (P-loop). 216595009888 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 216595009889 CGNR zinc finger; Region: zf-CGNR; pfam11706 216595009891 ggaaccnnnnnnnnnnnnnnnnccacnna 216595009893 diaminopimelate epimerase; Provisional; Region: PRK13577 216595009895 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 216595009896 Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432 216595009898 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595009899 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation,' the process of...; Region: Lipase_3; cd00519 216595009900 active site flap/lid [active] 216595009901 nucleophilic elbow; other site 216595009902 catalytic triad [active] 216595009904 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and...; Region: Bact_CD; cd01293 216595009905 cytosine deaminase; Provisional; Region: PRK05985 216595009906 active site 216595009908 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595009909 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 216595009910 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 216595009912 Sodium:solute symporter family; Region: SSF; cl00456 216595009914 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 216595009915 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 216595009916 nudix motif; other site 216595009919 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216595009920 non-specific DNA binding site [nucleotide binding]; other site 216595009921 salt bridge; other site 216595009922 sequence-specific DNA binding site [nucleotide binding]; other site 216595009924 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 216595009925 active site 216595009927 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 216595009929 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 216595009931 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216595009932 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595009933 active site 216595009934 phosphorylation site [posttranslational modification] 216595009935 intermolecular recognition site; other site 216595009936 dimerization interface [polypeptide binding]; other site 216595009937 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 216595009938 DNA binding site [nucleotide binding] 216595009941 sensor protein PhoQ; Provisional; Region: PRK10815 216595009942 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595009943 ATP binding site [chemical binding]; other site 216595009944 G-X-G motif; other site 216595009945 2 probable transmembrane helices predicted for PFLU2122 by TMHMM2.0 at aa 7-29 and 152-171 216595009949 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595009950 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595009951 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595009954 Predicted permease [General function prediction only]; Region: COG2056 216595009955 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 216595009956 12 probable transmembrane helices predicted for PFLU2124 by TMHMM2.0 at aa 35-57, 62-84, 91-113, 161-180, 192-214, 234-256, 277-299, 303-322, 335-357, 377-399, 406-428 and 457-479 216595009958 Cache domain; Region: Cache_2; cl07034 216595009959 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 216595009960 dimerization interface [polypeptide binding]; other site 216595009961 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595009962 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595009963 2 probable transmembrane helices predicted for PFLU2125 by TMHMM2.0 at aa 10-32 and 205-227 216595009967 putative protease; Provisional; Region: PRK15452 216595009968 Peptidase family U32; Region: Peptidase_U32; cl03113 216595009970 PS01276 Peptidase family U32 signature. 216595009971 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 216595009972 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 216595009973 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 216595009974 catalytic residues [active] 216595009975 5 probable transmembrane helices predicted for PFLU2128 by TMHMM2.0 at aa 7-29, 39-61, 74-96, 120-142 and 154-176 216595009978 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 216595009979 Domain of unknown function DUF20; Region: UPF0118; cl00465 216595009981 7 probable transmembrane helices predicted for PFLU2129 by TMHMM2.0 at aa 20-42, 63-85, 154-176, 214-233, 238-260, 267-289 and 309-343 216595009982 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 216595009983 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 216595009984 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 216595009985 shikimate binding site; other site 216595009986 NAD(P) binding site [chemical binding]; other site 216595009989 Protein of unknown function, DUF480; Region: DUF480; cl01209 216595009991 Domain of unknown function (DUF1993); Region: DUF1993; cl01567 216595009992 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 216595009993 UvrD/REP helicase; Region: UvrD-helicase; cl14126 216595009994 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 216595009995 PS00017 ATP/GTP-binding site motif A (P-loop). 216595009996 PS00017 ATP/GTP-binding site motif A (P-loop). 216595009998 DNA helicase, putative; Region: TIGR00376 216595009999 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595010000 Walker A motif; other site 216595010001 ATP binding site [chemical binding]; other site 216595010002 DNA helicase, putative; Region: TIGR00376 216595010003 PS00017 ATP/GTP-binding site motif A (P-loop). 216595010004 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 216595010006 PS00435 Peroxidases proximal heme-ligand signature. 216595010007 12 probable transmembrane helices predicted for PFLU2140 by TMHMM2.0 at aa 89-111, 131-153, 165-182, 186-208, 227-249, 253-275, 296-315, 330-352, 359-381, 385-407, 420-442 and 447-469 216595010008 putative arabinose transporter; Provisional; Region: PRK03545 216595010009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595010010 putative substrate translocation pore; other site 216595010012 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 216595010013 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595010014 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 216595010015 putative dimerization interface [polypeptide binding]; other site 216595010017 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595010018 Integral membrane protein TerC family; Region: TerC; cl10468 216595010019 7 probable transmembrane helices predicted for PFLU2143 by TMHMM2.0 at aa 15-37, 58-80, 85-103, 123-145, 160-182, 189-208 and 218-235 216595010021 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_N_Ure2p_like; cd03048 216595010022 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 216595010023 C-terminal domain interface [polypeptide binding]; other site 216595010024 GSH binding site (G-site) [chemical binding]; other site 216595010025 dimer interface [polypeptide binding]; other site 216595010026 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 216595010027 dimer interface [polypeptide binding]; other site 216595010028 N-terminal domain interface [polypeptide binding]; other site 216595010031 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 216595010032 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 216595010034 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 216595010035 dimer interface [polypeptide binding]; other site 216595010036 active site 216595010037 Schiff base residues; other site 216595010039 PS00169 Delta-aminolevulinic acid dehydratase active site. 216595010040 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 216595010041 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595010043 1 probable transmembrane helix predicted for PFLU2149 by TMHMM2.0 at aa 234-253 216595010044 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595010045 acetyl-CoA acetyltransferase; Provisional; Region: PRK05656 216595010046 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 216595010047 dimer interface [polypeptide binding]; other site 216595010048 active site 216595010050 PS00099 Thiolases active site. 216595010051 PS00737 Thiolases signature 2. 216595010053 PS00098 Thiolases acyl-enzyme intermediate signature. 216595010054 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 216595010056 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 216595010057 PS01274 CoA transferases signature 2. 216595010058 1 probable transmembrane helix predicted for PFLU2151 by TMHMM2.0 at aa 20-37 216595010059 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 216595010061 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595010062 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595010063 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 216595010064 putative dimerization interface [polypeptide binding]; other site 216595010066 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595010068 NAD-dependent deacetylase; Provisional; Region: PRK05333 216595010069 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/...; Region: SIRT4; cd01409 216595010070 NAD+ binding site [chemical binding]; other site 216595010071 substrate binding site [chemical binding]; other site 216595010072 Zn binding site [ion binding]; other site 216595010074 FOG: CBS domain [General function prediction only]; Region: COG0517 216595010075 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_10; cd04623 216595010077 DNA topoisomerase III; Provisional; Region: PRK07726 216595010078 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by:...; Region: TOPRIM_TopoIA_TopoIII; cd03362 216595010079 active site 216595010080 putative interdomain interaction site [polypeptide binding]; other site 216595010081 putative metal-binding site [ion binding]; other site 216595010082 putative nucleotide binding site [chemical binding]; other site 216595010083 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 216595010084 domain I; other site 216595010085 DNA binding groove [nucleotide binding] 216595010086 phosphate binding site [ion binding]; other site 216595010087 domain II; other site 216595010088 domain III; other site 216595010089 nucleotide binding site [chemical binding]; other site 216595010090 catalytic site [active] 216595010091 domain IV; other site 216595010093 PS00396 Prokaryotic DNA topoisomerase I active site. 216595010095 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 216595010096 Integrase core domain; Region: rve; cl01316 216595010098 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595010099 putative substrate translocation pore; other site 216595010100 metabolite-proton symporter; Region: 2A0106; TIGR00883 216595010102 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595010103 PS00217 Sugar transport proteins signature 2. 216595010104 choline dehydrogenase; Validated; Region: PRK02106 216595010105 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595010106 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 216595010109 PS00624 GMC oxidoreductases signature 2. 216595010110 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595010111 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595010112 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595010113 dimerization interface [polypeptide binding]; other site 216595010115 PS00044 Bacterial regulatory proteins, lysR family signature. 216595010117 A new structural DNA glycosylase; Region: AlkD_like; cl11434 216595010118 A new structural DNA glycosylase; Region: AlkD_like; cl11434 216595010119 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 216595010120 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 216595010122 PS00181 Glutamine synthetase putative ATP-binding region signature. 216595010123 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216595010124 non-specific DNA binding site [nucleotide binding]; other site 216595010125 salt bridge; other site 216595010126 sequence-specific DNA binding site [nucleotide binding]; other site 216595010127 Cupin domain; Region: Cupin_2; cl09118 216595010130 Transposase IS200 like; Region: Y1_Tnp; cl00848 216595010132 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 216595010133 Protein of unknown function (DUF1652); Region: DUF1652; pfam07865 216595010134 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 216595010135 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 216595010136 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 216595010137 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 216595010138 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 216595010139 DNA binding residues [nucleotide binding] 216595010140 dimerization interface [polypeptide binding]; other site 216595010144 4 probable transmembrane helices predicted for PFLU2170 by TMHMM2.0 at aa 21-43, 63-85, 98-120 and 297-319 216595010145 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 216595010146 N-acetyl-D-glucosamine binding site [chemical binding]; other site 216595010147 catalytic residue [active] 216595010148 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595010149 Predicted amidohydrolase [General function prediction only]; Region: COG0388 216595010150 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_2; cd07580 216595010151 putative active site [active] 216595010152 catalytic triad [active] 216595010153 putative dimer interface [polypeptide binding]; other site 216595010155 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595010156 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 216595010157 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 216595010159 PS00147 Arginase family signature 1. 216595010161 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 216595010162 nickel responsive regulator; Provisional; Region: PRK00630 216595010164 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 216595010166 PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2. 216595010167 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 216595010169 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 216595010170 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 216595010171 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216595010172 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 216595010173 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 216595010174 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 216595010177 8 probable transmembrane helices predicted for PFLU2178 by TMHMM2.0 at aa 249-271, 291-313, 323-345, 709-731, 772-794, 807-826, 841-863 and 868-890 216595010179 PS00154 E1-E2 ATPases phosphorylation site. 216595010180 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 216595010181 MgtC family; Region: MgtC; cl12207 216595010182 4 probable transmembrane helices predicted for PFLU2179 by TMHMM2.0 at aa 7-29, 39-56, 68-87 and 107-129 216595010184 PS00387 Inorganic pyrophosphatase signature. 216595010185 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216595010186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595010187 active site 216595010188 phosphorylation site [posttranslational modification] 216595010189 intermolecular recognition site; other site 216595010190 dimerization interface [polypeptide binding]; other site 216595010191 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 216595010192 DNA binding residues [nucleotide binding] 216595010193 dimerization interface [polypeptide binding]; other site 216595010196 PS00622 Bacterial regulatory proteins, luxR family signature. 216595010197 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 216595010198 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595010199 substrate binding pocket [chemical binding]; other site 216595010200 membrane-bound complex binding site; other site 216595010201 hinge residues; other site 216595010202 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595010203 substrate binding pocket [chemical binding]; other site 216595010204 membrane-bound complex binding site; other site 216595010205 hinge residues; other site 216595010206 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 216595010207 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595010208 dimer interface [polypeptide binding]; other site 216595010209 phosphorylation site [posttranslational modification] 216595010210 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595010211 ATP binding site [chemical binding]; other site 216595010212 Mg2+ binding site [ion binding]; other site 216595010213 G-X-G motif; other site 216595010214 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595010215 active site 216595010216 phosphorylation site [posttranslational modification] 216595010217 intermolecular recognition site; other site 216595010218 dimerization interface [polypeptide binding]; other site 216595010219 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 216595010220 1 probable transmembrane helix predicted for PFLU2181 by TMHMM2.0 at aa 537-559 216595010226 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 216595010227 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 216595010228 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216595010229 active site 216595010230 catalytic tetrad [active] 216595010232 PS00062 Aldo/keto reductase family signature 2. 216595010234 NeuB family; Region: NeuB; cl00496 216595010235 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 216595010237 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 216595010238 active site 216595010239 catalytic triad [active] 216595010240 dimer interface [polypeptide binding]; other site 216595010242 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 216595010244 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 216595010245 response regulator; Provisional; Region: PRK09483 216595010246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595010247 active site 216595010248 phosphorylation site [posttranslational modification] 216595010249 intermolecular recognition site; other site 216595010250 dimerization interface [polypeptide binding]; other site 216595010251 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 216595010252 DNA binding residues [nucleotide binding] 216595010253 dimerization interface [polypeptide binding]; other site 216595010256 PS00622 Bacterial regulatory proteins, luxR family signature. 216595010257 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 216595010258 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 216595010259 GIY-YIG motif/motif A; other site 216595010260 active site 216595010261 catalytic site [active] 216595010262 putative DNA binding site [nucleotide binding]; other site 216595010263 metal binding site [ion binding]; metal-binding site 216595010264 UvrB/uvrC motif; Region: UVR; pfam02151 216595010265 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 216595010270 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 216595010271 2 probable transmembrane helices predicted for PFLU2191 by TMHMM2.0 at aa 5-27 and 149-171 216595010273 PS00379 CDP-alcohol phosphatidyltransferases signature. 216595010274 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 216595010275 catalytic motif [active] 216595010276 Zn binding site [ion binding]; other site 216595010278 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 216595010279 LysE type translocator; Region: LysE; cl00565 216595010281 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 216595010282 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 216595010284 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216595010285 PS00659 Glycosyl hydrolases family 5 signature. 216595010286 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 216595010287 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 216595010288 inhibitor-cofactor binding pocket; inhibition site 216595010289 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595010290 catalytic residue [active] 216595010292 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 216595010293 M28, and M42; Region: Zinc_peptidase_like; cl14876 216595010294 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 216595010295 metal binding site [ion binding]; metal-binding site 216595010298 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 216595010299 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 216595010300 Flavin binding site [chemical binding]; other site 216595010302 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 216595010303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595010304 D-galactonate transporter; Region: 2A0114; TIGR00893 216595010305 putative substrate translocation pore; other site 216595010307 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 216595010308 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216595010309 N-terminal plug; other site 216595010310 ligand-binding site [chemical binding]; other site 216595010313 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 216595010314 substrate binding site [chemical binding]; other site 216595010315 oxyanion hole (OAH) forming residues; other site 216595010316 trimer interface [polypeptide binding]; other site 216595010318 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH5; cd08259 216595010319 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 216595010320 putative NAD(P) binding site [chemical binding]; other site 216595010321 catalytic Zn binding site [ion binding]; other site 216595010322 structural Zn binding site [ion binding]; other site 216595010324 PS00059 Zinc-containing alcohol dehydrogenases signature. 216595010326 PS01162 Quinone oxidoreductase / zeta-crystallin signature. 216595010327 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 216595010328 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595010330 PS00455 Putative AMP-binding domain signature. 216595010331 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595010332 Transcriptional regulator [Transcription]; Region: IclR; COG1414 216595010335 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595010336 NAD(P) binding site [chemical binding]; other site 216595010337 active site 216595010339 1 probable transmembrane helix predicted for PFLU2208 by TMHMM2.0 at aa 7-25 216595010340 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595010341 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 216595010342 Walker A motif; other site 216595010343 ATP binding site [chemical binding]; other site 216595010344 Walker B motif; other site 216595010345 arginine finger; other site 216595010346 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 216595010348 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 216595010349 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 216595010350 PS00688 Sigma-54 interaction domain C-terminal part signature. 216595010351 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 216595010352 active site 216595010353 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 216595010354 dimer interface [polypeptide binding]; other site 216595010355 non-prolyl cis peptide bond; other site 216595010356 insertion regions; other site 216595010358 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 216595010359 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 216595010360 PS00019 Actinin-type actin-binding domain signature 1. 216595010361 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 216595010362 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 216595010364 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 216595010365 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 216595010367 Survival protein SurE; Region: SurE; cl00448 216595010369 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 216595010370 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 216595010371 active site 216595010372 non-prolyl cis peptide bond; other site 216595010374 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 216595010375 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216595010376 N-terminal plug; other site 216595010377 ligand-binding site [chemical binding]; other site 216595010380 PS00430 TonB-dependent receptor proteins signature 1. 216595010381 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of highly-; Region: nylC_like; cd02252 216595010382 putative active site pocket [active] 216595010383 cleavage site 216595010385 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 216595010387 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 216595010388 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 216595010390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595010391 dimer interface [polypeptide binding]; other site 216595010392 conserved gate region; other site 216595010393 putative PBP binding loops; other site 216595010394 ABC-ATPase subunit interface; other site 216595010395 6 probable transmembrane helices predicted for PFLU2221 by TMHMM2.0 at aa 7-29, 101-123, 143-165, 185-207, 243-265 and 285-307 216595010397 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595010398 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 216595010399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595010400 dimer interface [polypeptide binding]; other site 216595010401 conserved gate region; other site 216595010402 putative PBP binding loops; other site 216595010403 ABC-ATPase subunit interface; other site 216595010404 5 probable transmembrane helices predicted for PFLU2222 by TMHMM2.0 at aa 26-48, 95-117, 138-160, 212-234 and 255-277 216595010406 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 216595010407 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 216595010408 Walker A/P-loop; other site 216595010409 ATP binding site [chemical binding]; other site 216595010410 Q-loop/lid; other site 216595010411 ABC transporter signature motif; other site 216595010412 Walker B; other site 216595010413 D-loop; other site 216595010414 H-loop/switch region; other site 216595010415 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 216595010416 Walker A/P-loop; other site 216595010417 ATP binding site [chemical binding]; other site 216595010418 Q-loop/lid; other site 216595010419 ABC transporter signature motif; other site 216595010420 Walker B; other site 216595010421 D-loop; other site 216595010422 H-loop/switch region; other site 216595010423 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216595010425 PS00017 ATP/GTP-binding site motif A (P-loop). 216595010426 PS00211 ABC transporters family signature. 216595010428 PS00017 ATP/GTP-binding site motif A (P-loop). 216595010429 PS00211 ABC transporters family signature. 216595010430 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595010431 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216595010433 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 216595010434 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595010435 Walker A/P-loop; other site 216595010436 ATP binding site [chemical binding]; other site 216595010437 Q-loop/lid; other site 216595010438 ABC transporter signature motif; other site 216595010439 Walker B; other site 216595010440 D-loop; other site 216595010441 H-loop/switch region; other site 216595010442 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595010443 dimer interface [polypeptide binding]; other site 216595010444 conserved gate region; other site 216595010445 ABC-ATPase subunit interface; other site 216595010447 PS00017 ATP/GTP-binding site motif A (P-loop). 216595010448 PS00211 ABC transporters family signature. 216595010449 9 probable transmembrane helices predicted for PFLU2225 by TMHMM2.0 at aa 379-401, 414-436, 469-491, 496-515, 520-539, 546-568, 594-616, 661-683 and 698-717 216595010451 PS00017 ATP/GTP-binding site motif A (P-loop). 216595010452 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595010453 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 216595010454 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 216595010456 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105 216595010457 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 216595010459 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595010460 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 216595010462 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595010463 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595010464 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 216595010465 putative dimerization interface [polypeptide binding]; other site 216595010468 PS00044 Bacterial regulatory proteins, lysR family signature. 216595010469 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595010470 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 216595010471 substrate binding pocket [chemical binding]; other site 216595010472 membrane-bound complex binding site; other site 216595010473 hinge residues; other site 216595010475 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 216595010476 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595010477 substrate binding pocket [chemical binding]; other site 216595010478 membrane-bound complex binding site; other site 216595010479 hinge residues; other site 216595010480 PS00430 TonB-dependent receptor proteins signature 1. 216595010481 PS00099 Thiolases active site. 216595010483 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 216595010484 FAD binding domain; Region: FAD_binding_4; pfam01565 216595010487 hypothetical protein; Validated; Region: PRK07682 216595010488 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216595010489 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595010490 homodimer interface [polypeptide binding]; other site 216595010491 catalytic residue [active] 216595010493 PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 216595010494 PS00012 Phosphopantetheine attachment site. 216595010495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595010496 dimer interface [polypeptide binding]; other site 216595010497 conserved gate region; other site 216595010498 putative PBP binding loops; other site 216595010499 ABC-ATPase subunit interface; other site 216595010500 5 probable transmembrane helices predicted for PFLU2234 by TMHMM2.0 at aa 4-26, 39-61, 96-118, 184-203 and 208-230 216595010502 PS00041 Bacterial regulatory proteins, araC family signature. 216595010503 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216595010504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595010505 dimer interface [polypeptide binding]; other site 216595010506 conserved gate region; other site 216595010507 putative PBP binding loops; other site 216595010508 ABC-ATPase subunit interface; other site 216595010509 6 probable transmembrane helices predicted for PFLU2235 by TMHMM2.0 at aa 21-43, 58-80, 100-122, 132-154, 193-210 and 225-247 216595010511 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 216595010512 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 216595010513 Walker A/P-loop; other site 216595010514 ATP binding site [chemical binding]; other site 216595010515 Q-loop/lid; other site 216595010516 ABC transporter signature motif; other site 216595010517 Walker B; other site 216595010518 D-loop; other site 216595010519 H-loop/switch region; other site 216595010521 PS00017 ATP/GTP-binding site motif A (P-loop). 216595010522 PS00211 ABC transporters family signature. 216595010523 Cysteine dioxygenase type I; Region: CDO_I; cl02350 216595010524 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 216595010525 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_N_Ure2p_like; cd03048 216595010526 C-terminal domain interface [polypeptide binding]; other site 216595010527 GSH binding site (G-site) [chemical binding]; other site 216595010528 dimer interface [polypeptide binding]; other site 216595010529 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 216595010530 N-terminal domain interface [polypeptide binding]; other site 216595010531 dimer interface [polypeptide binding]; other site 216595010532 substrate binding pocket (H-site) [chemical binding]; other site 216595010535 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 216595010536 active site residue [active] 216595010537 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative...; Region: 4RHOD_Repeat_2; cd01533 216595010538 active site residue [active] 216595010539 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 216595010540 active site residue [active] 216595010541 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 216595010542 active site residue [active] 216595010543 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 216595010544 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 216595010545 homodimer interface [polypeptide binding]; other site 216595010546 substrate-cofactor binding pocket; other site 216595010547 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595010548 catalytic residue [active] 216595010551 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595010552 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 216595010553 DNA-binding site [nucleotide binding]; DNA binding site 216595010554 UTRA domain; Region: UTRA; cl01230 216595010557 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216595010558 ligand binding site [chemical binding]; other site 216595010560 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216595010561 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595010562 active site 216595010563 phosphorylation site [posttranslational modification] 216595010564 intermolecular recognition site; other site 216595010565 dimerization interface [polypeptide binding]; other site 216595010566 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 216595010567 DNA binding residues [nucleotide binding] 216595010568 dimerization interface [polypeptide binding]; other site 216595010571 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 216595010572 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595010573 dimer interface [polypeptide binding]; other site 216595010574 phosphorylation site [posttranslational modification] 216595010575 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595010576 ATP binding site [chemical binding]; other site 216595010577 Mg2+ binding site [ion binding]; other site 216595010578 G-X-G motif; other site 216595010579 Response regulator receiver domain; Region: Response_reg; pfam00072 216595010580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595010581 active site 216595010582 phosphorylation site [posttranslational modification] 216595010583 intermolecular recognition site; other site 216595010584 dimerization interface [polypeptide binding]; other site 216595010588 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595010589 PS00017 ATP/GTP-binding site motif A (P-loop). 216595010590 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595010592 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216595010593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595010594 active site 216595010595 phosphorylation site [posttranslational modification] 216595010596 intermolecular recognition site; other site 216595010597 dimerization interface [polypeptide binding]; other site 216595010598 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 216595010599 DNA binding residues [nucleotide binding] 216595010600 dimerization interface [polypeptide binding]; other site 216595010602 PS00017 ATP/GTP-binding site motif A (P-loop). 216595010604 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 216595010605 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595010606 dimer interface [polypeptide binding]; other site 216595010607 phosphorylation site [posttranslational modification] 216595010608 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595010609 ATP binding site [chemical binding]; other site 216595010610 Mg2+ binding site [ion binding]; other site 216595010611 G-X-G motif; other site 216595010612 Response regulator receiver domain; Region: Response_reg; pfam00072 216595010613 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595010614 active site 216595010615 phosphorylation site [posttranslational modification] 216595010616 intermolecular recognition site; other site 216595010617 dimerization interface [polypeptide binding]; other site 216595010618 5 probable transmembrane helices predicted for PFLU2249 by TMHMM2.0 at aa 42-64, 69-91, 111-133, 146-168 and 175-192 216595010622 1 probable transmembrane helix predicted for PFLU2250 by TMHMM2.0 at aa 59-81 216595010623 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 216595010624 2 probable transmembrane helices predicted for PFLU2252 by TMHMM2.0 at aa 12-34 and 108-130 216595010625 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595010626 1 probable transmembrane helix predicted for PFLU2253 by TMHMM2.0 at aa 172-194 216595010627 DinB superfamily; Region: DinB_2; cl00986 216595010629 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 216595010630 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216595010631 ligand binding site [chemical binding]; other site 216595010632 flexible hinge region; other site 216595010633 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 216595010634 putative switch regulator; other site 216595010635 non-specific DNA interactions [nucleotide binding]; other site 216595010636 DNA binding site [nucleotide binding] 216595010637 sequence specific DNA binding site [nucleotide binding]; other site 216595010638 putative cAMP binding site [chemical binding]; other site 216595010641 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 216595010642 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 216595010643 NAD binding site [chemical binding]; other site 216595010644 homotetramer interface [polypeptide binding]; other site 216595010645 homodimer interface [polypeptide binding]; other site 216595010646 active site 216595010648 PS00061 Short-chain dehydrogenases/reductases family signature. 216595010649 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 216595010650 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 216595010651 conserved cys residue [active] 216595010655 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 216595010657 CHASE3 domain; Region: CHASE3; cl05000 216595010658 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595010659 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595010660 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595010664 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 216595010665 nudix motif; other site 216595010667 PS00893 mutT domain signature. 216595010668 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 216595010669 Amino acid permease; Region: AA_permease; pfam00324 216595010671 12 probable transmembrane helices predicted for PFLU2264 by TMHMM2.0 at aa 21-38, 42-64, 97-119, 129-148, 160-182, 197-219, 244-266, 291-313, 337-359, 363-385, 405-427 and 431-453 216595010672 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 216595010673 PS00218 Amino acid permeases signature. 216595010674 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 216595010675 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 216595010676 conserved cys residue [active] 216595010677 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595010680 PS00041 Bacterial regulatory proteins, araC family signature. 216595010682 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 216595010683 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 216595010684 putative ligand binding site [chemical binding]; other site 216595010685 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595010686 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595010687 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595010688 dimer interface [polypeptide binding]; other site 216595010689 phosphorylation site [posttranslational modification] 216595010690 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595010691 ATP binding site [chemical binding]; other site 216595010692 Mg2+ binding site [ion binding]; other site 216595010693 G-X-G motif; other site 216595010694 Response regulator receiver domain; Region: Response_reg; pfam00072 216595010695 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595010696 active site 216595010697 phosphorylation site [posttranslational modification] 216595010698 intermolecular recognition site; other site 216595010699 dimerization interface [polypeptide binding]; other site 216595010700 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595010701 ATP binding site [chemical binding]; other site 216595010702 Mg2+ binding site [ion binding]; other site 216595010703 G-X-G motif; other site 216595010704 1 probable transmembrane helix predicted for PFLU2267 by TMHMM2.0 at aa 12-34 216595010710 Rhamnogalacturonase B, N-terminal; Region: RhgB_N; pfam09284 216595010712 Pectate lyase; Region: Pec_lyase_C; cl01593 216595010714 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 216595010715 Cytochrome c; Region: Cytochrom_C; cl11414 216595010717 PS00190 Cytochrome c family heme-binding site signature. 216595010718 PS00190 Cytochrome c family heme-binding site signature. 216595010719 PS00190 Cytochrome c family heme-binding site signature. 216595010720 1 probable transmembrane helix predicted for PFLU2270 by TMHMM2.0 at aa 7-29 216595010721 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 216595010722 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 216595010723 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 216595010724 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 216595010725 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 216595010728 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 216595010729 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 216595010732 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 216595010733 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216595010734 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595010735 DNA-binding site [nucleotide binding]; DNA binding site 216595010736 FCD domain; Region: FCD; cl11656 216595010739 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 216595010740 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595010741 NAD(P) binding site [chemical binding]; other site 216595010742 active site 216595010744 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 216595010746 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 216595010747 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 4. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved...; Region: MR_like_4; cd03329 216595010748 putative active site pocket [active] 216595010749 metal binding site [ion binding]; metal-binding site 216595010752 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 216595010753 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 216595010755 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216595010756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595010757 dimer interface [polypeptide binding]; other site 216595010758 conserved gate region; other site 216595010759 putative PBP binding loops; other site 216595010760 ABC-ATPase subunit interface; other site 216595010761 6 probable transmembrane helices predicted for PFLU2279 by TMHMM2.0 at aa 29-51, 113-135, 156-178, 218-237, 276-298 and 318-340 216595010763 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 216595010764 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 216595010766 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 216595010767 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595010768 dimer interface [polypeptide binding]; other site 216595010769 conserved gate region; other site 216595010770 ABC-ATPase subunit interface; other site 216595010771 5 probable transmembrane helices predicted for PFLU2281 by TMHMM2.0 at aa 45-67, 112-134, 141-163, 228-250 and 271-293 216595010773 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 216595010774 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 216595010775 Walker A/P-loop; other site 216595010776 ATP binding site [chemical binding]; other site 216595010777 Q-loop/lid; other site 216595010778 ABC transporter signature motif; other site 216595010779 Walker B; other site 216595010780 D-loop; other site 216595010781 H-loop/switch region; other site 216595010783 PS00017 ATP/GTP-binding site motif A (P-loop). 216595010784 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 216595010785 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 216595010786 Walker A/P-loop; other site 216595010787 ATP binding site [chemical binding]; other site 216595010788 Q-loop/lid; other site 216595010789 ABC transporter signature motif; other site 216595010790 Walker B; other site 216595010791 D-loop; other site 216595010792 H-loop/switch region; other site 216595010794 PS00017 ATP/GTP-binding site motif A (P-loop). 216595010795 PS00211 ABC transporters family signature. 216595010796 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 216595010797 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 216595010798 putative active site [active] 216595010799 catalytic residue [active] 216595010801 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 216595010802 putative substrate binding pocket [chemical binding]; other site 216595010803 trimer interface [polypeptide binding]; other site 216595010804 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 216595010805 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 216595010808 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 216595010809 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595010810 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447 216595010811 putative dimerization interface [polypeptide binding]; other site 216595010812 putative substrate binding pocket [chemical binding]; other site 216595010815 PS00044 Bacterial regulatory proteins, lysR family signature. 216595010816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595010817 D-galactonate transporter; Region: 2A0114; TIGR00893 216595010818 putative substrate translocation pore; other site 216595010819 12 probable transmembrane helices predicted for PFLU2288 by TMHMM2.0 at aa 25-47, 62-84, 91-110, 116-138, 151-173, 183-205, 253-275, 290-312, 319-338, 342-364, 377-399 and 409-426 216595010821 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of...; Region: D-glucarate_dehydratase; cd03323 216595010822 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 216595010823 active site 216595010824 tetramer interface [polypeptide binding]; other site 216595010827 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 216595010828 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595010830 PS00455 Putative AMP-binding domain signature. 216595010831 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595010832 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595010833 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 216595010834 putative effector binding pocket; other site 216595010835 dimerization interface [polypeptide binding]; other site 216595010838 PS00044 Bacterial regulatory proteins, lysR family signature. 216595010839 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 216595010840 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216595010841 tetrameric interface [polypeptide binding]; other site 216595010842 NAD binding site [chemical binding]; other site 216595010843 catalytic residues [active] 216595010845 PS00070 Aldehyde dehydrogenases cysteine active site. 216595010846 Pectate lyase; Region: Pec_lyase_C; cl01593 216595010848 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 216595010849 active site 216595010851 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595010852 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595010853 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595010854 2 probable transmembrane helices predicted for PFLU2295 by TMHMM2.0 at aa 4-26 and 310-332 216595010857 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 216595010858 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 216595010859 putative ligand binding site [chemical binding]; other site 216595010861 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 216595010862 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216595010863 TM-ABC transporter signature motif; other site 216595010865 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 216595010866 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 216595010867 Walker A/P-loop; other site 216595010868 ATP binding site [chemical binding]; other site 216595010869 Q-loop/lid; other site 216595010870 ABC transporter signature motif; other site 216595010871 Walker B; other site 216595010872 D-loop; other site 216595010873 H-loop/switch region; other site 216595010874 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 216595010876 PS00211 ABC transporters family signature. 216595010878 PS00017 ATP/GTP-binding site motif A (P-loop). 216595010879 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 216595010880 putative ligand binding site [chemical binding]; other site 216595010882 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 216595010883 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 216595010884 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 216595010886 PS00172 Xylose isomerase signature 1. 216595010887 PS00173 Xylose isomerase signature 2. 216595010888 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 216595010889 putative dimerization interface [polypeptide binding]; other site 216595010890 putative ligand binding site [chemical binding]; other site 216595010891 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216595010892 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595010894 PS00041 Bacterial regulatory proteins, araC family signature. 216595010896 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 216595010897 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 216595010899 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 216595010900 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 216595010901 Trp docking motif; other site 216595010902 active site 216595010903 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 216595010904 Trp docking motif; other site 216595010905 'Velcro' closure; other site 216595010910 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595010911 Transcriptional regulator [Transcription]; Region: IclR; COG1414 216595010913 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595010914 putative substrate translocation pore; other site 216595010916 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 216595010917 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595010920 PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. 216595010921 PS00017 ATP/GTP-binding site motif A (P-loop). 216595010922 hypothetical protein; Validated; Region: PRK06201 216595010923 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 216595010925 Bacterial protein of unknown function (DUF894); Region: DUF894; pfam05977 216595010927 9 probable transmembrane helices predicted for PFLU2309 by TMHMM2.0 at aa 53-75, 87-109, 175-197, 231-253, 263-285, 292-314, 318-340, 353-375 and 380-402 216595010928 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 216595010929 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 216595010931 1 probable transmembrane helix predicted for PFLU2311 by TMHMM2.0 at aa 7-29 216595010932 PS00017 ATP/GTP-binding site motif A (P-loop). 216595010934 PS00430 TonB-dependent receptor proteins signature 1. 216595010935 1 probable transmembrane helix predicted for PFLU2312 by TMHMM2.0 at aa 127-149 216595010938 Flavin Reductases; Region: FlaRed; cl00801 216595010940 PS00501 Signal peptidases I serine active site. 216595010941 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 216595010942 Sodium:solute symporter family; Region: SSF; cl00456 216595010944 12 probable transmembrane helices predicted for PFLU2315 by TMHMM2.0 at aa 32-54, 59-81, 102-124, 139-161, 168-185, 200-217, 238-260, 283-305, 326-348, 352-371, 392-414 and 434-451 216595010945 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 216595010946 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 216595010947 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 216595010951 Sarcosine oxidase, delta subunit family; Region: SoxD; cl01767 216595010953 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 216595010954 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 216595010955 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 216595010957 PS00017 ATP/GTP-binding site motif A (P-loop). 216595010958 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14194 216595010959 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 216595010960 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 216595010961 homodimer interface [polypeptide binding]; other site 216595010962 NADP binding site [chemical binding]; other site 216595010963 substrate binding site [chemical binding]; other site 216595010965 PS00767 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2. 216595010967 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 216595010968 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 216595010969 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 216595010970 putative active site [active] 216595010971 putative substrate binding site [chemical binding]; other site 216595010972 putative cosubstrate binding site; other site 216595010973 catalytic site [active] 216595010975 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 216595010976 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216595010977 non-specific DNA binding site [nucleotide binding]; other site 216595010978 salt bridge; other site 216595010979 sequence-specific DNA binding site [nucleotide binding]; other site 216595010980 Cupin domain; Region: Cupin_2; cl09118 216595010983 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 216595010984 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 216595010986 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 216595010987 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 216595010988 putative active site [active] 216595010989 PS00443 Glutamine amidotransferases class-II active site. 216595010991 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 216595010992 domain_subunit interface; other site 216595010994 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 216595010995 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 216595010996 active site 216595010997 FMN binding site [chemical binding]; other site 216595010998 substrate binding site [chemical binding]; other site 216595010999 3Fe-4S cluster binding site [ion binding]; other site 216595011001 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 216595011002 12 probable transmembrane helices predicted for PFLU2327 by TMHMM2.0 at aa 7-26, 41-63, 70-92, 137-156, 163-185, 200-222, 235-254, 264-286, 298-320, 324-341, 353-374 and 389-411 216595011004 PS01219 Ammonium transporters signature. 216595011005 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14194 216595011006 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 216595011007 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 216595011008 homodimer interface [polypeptide binding]; other site 216595011009 NADP binding site [chemical binding]; other site 216595011010 substrate binding site [chemical binding]; other site 216595011012 PS00767 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2. 216595011014 PS00766 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 1. 216595011015 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 216595011017 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 216595011018 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 216595011019 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 216595011022 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 216595011023 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 216595011025 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 216595011026 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 216595011027 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 216595011028 putative active site [active] 216595011029 putative substrate binding site [chemical binding]; other site 216595011030 putative cosubstrate binding site; other site 216595011031 catalytic site [active] 216595011033 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595011034 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 216595011035 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 216595011039 PS00017 ATP/GTP-binding site motif A (P-loop). 216595011040 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 216595011041 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 216595011042 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 216595011043 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-...; Region: PDR_like; cd06185 216595011044 FMN-binding pocket [chemical binding]; other site 216595011045 flavin binding motif; other site 216595011046 phosphate binding motif [ion binding]; other site 216595011047 beta-alpha-beta structure motif; other site 216595011048 NAD binding pocket [chemical binding]; other site 216595011049 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216595011050 catalytic loop [active] 216595011051 iron binding site [ion binding]; other site 216595011053 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 216595011056 PS00190 Cytochrome c family heme-binding site signature. 216595011057 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 216595011058 Histidine kinase; Region: HisKA_3; pfam07730 216595011059 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595011060 ATP binding site [chemical binding]; other site 216595011061 Mg2+ binding site [ion binding]; other site 216595011062 G-X-G motif; other site 216595011064 transcriptional regulator NarL; Provisional; Region: PRK10651 216595011065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595011066 active site 216595011067 phosphorylation site [posttranslational modification] 216595011068 intermolecular recognition site; other site 216595011069 dimerization interface [polypeptide binding]; other site 216595011070 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 216595011071 DNA binding residues [nucleotide binding] 216595011072 dimerization interface [polypeptide binding]; other site 216595011075 PS00622 Bacterial regulatory proteins, luxR family signature. 216595011076 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216595011077 putative active site [active] 216595011078 heme pocket [chemical binding]; other site 216595011079 PAS fold; Region: PAS_3; pfam08447 216595011081 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 216595011082 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595011083 Walker A/P-loop; other site 216595011084 ATP binding site [chemical binding]; other site 216595011085 Q-loop/lid; other site 216595011086 ABC transporter signature motif; other site 216595011087 Walker B; other site 216595011088 D-loop; other site 216595011089 H-loop/switch region; other site 216595011090 TOBE domain; Region: TOBE_2; cl01440 216595011093 PS00211 ABC transporters family signature. 216595011094 PS00017 ATP/GTP-binding site motif A (P-loop). 216595011095 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595011096 dimer interface [polypeptide binding]; other site 216595011097 conserved gate region; other site 216595011098 putative PBP binding loops; other site 216595011099 ABC-ATPase subunit interface; other site 216595011101 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595011102 dimer interface [polypeptide binding]; other site 216595011103 conserved gate region; other site 216595011104 putative PBP binding loops; other site 216595011105 ABC-ATPase subunit interface; other site 216595011107 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595011108 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595011110 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK12485 216595011111 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 216595011112 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 216595011113 dimerization interface [polypeptide binding]; other site 216595011114 active site 216595011117 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 216595011119 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 216595011120 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 216595011121 nudix motif; other site 216595011123 PS00893 mutT domain signature. 216595011124 Transcriptional regulators [Transcription]; Region: GntR; COG1802 216595011125 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595011126 DNA-binding site [nucleotide binding]; DNA binding site 216595011127 FCD domain; Region: FCD; cl11656 216595011130 PS00043 Bacterial regulatory proteins, gntR family signature. 216595011131 Flavin Reductases; Region: FlaRed; cl00801 216595011133 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216595011134 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 216595011135 NAD(P) binding site [chemical binding]; other site 216595011136 catalytic residues [active] 216595011138 PS00687 Aldehyde dehydrogenases glutamic acid active site. 216595011139 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 216595011140 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595011142 Protein of unknown function (DUF1185); Region: DUF1185; pfam06684 216595011144 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 216595011145 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595011147 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 216595011149 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 216595011150 intersubunit interface [polypeptide binding]; other site 216595011151 active site 216595011152 Zn2+ binding site [ion binding]; other site 216595011154 GntP family permease; Region: GntP_permease; cl15264 216595011155 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 216595011156 GntP family permease; Region: GntP_permease; cl15264 216595011157 12 probable transmembrane helices predicted for PFLU2355 by TMHMM2.0 at aa 12-34, 38-57, 74-96, 116-138, 151-170, 190-209, 276-298, 313-335, 348-370, 385-407, 438-460 and 475-497 216595011159 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 216595011161 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 216595011162 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595011163 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 216595011166 PS00894 Bacterial regulatory proteins, deoR family signature. 216595011167 Cache domain; Region: Cache_1; pfam02743 216595011168 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595011169 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595011170 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595011174 PS00017 ATP/GTP-binding site motif A (P-loop). 216595011175 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 216595011177 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216595011178 metal binding site [ion binding]; metal-binding site 216595011179 active site 216595011180 I-site; other site 216595011181 PS00294 Prenyl group binding site (CAAX box). 216595011182 6 probable transmembrane helices predicted for PFLU2361 by TMHMM2.0 at aa 13-35, 40-59, 66-88, 93-115, 120-139 and 143-165 216595011184 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 216595011185 active site 216595011186 metal binding site [ion binding]; metal-binding site 216595011187 homotetramer interface [polypeptide binding]; other site 216595011189 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595011191 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 216595011192 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 216595011193 active site 216595011194 FMN binding site [chemical binding]; other site 216595011195 substrate binding site [chemical binding]; other site 216595011196 homotetramer interface [polypeptide binding]; other site 216595011197 catalytic residue [active] 216595011199 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 216595011200 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216595011201 N-terminal plug; other site 216595011202 ligand-binding site [chemical binding]; other site 216595011205 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216595011206 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595011207 DNA-binding site [nucleotide binding]; DNA binding site 216595011208 FCD domain; Region: FCD; cl11656 216595011211 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 216595011212 Dehydratase family; Region: ILVD_EDD; cl00340 216595011214 PS00017 ATP/GTP-binding site motif A (P-loop). 216595011215 PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1. 216595011216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595011217 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 216595011218 putative substrate translocation pore; other site 216595011219 12 probable transmembrane helices predicted for PFLU2368 by TMHMM2.0 at aa 35-52, 67-89, 105-124, 129-151, 163-182, 197-219, 265-287, 297-319, 332-349, 354-376, 389-411 and 421-443 216595011221 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 216595011223 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 216595011224 dimer interface [polypeptide binding]; other site 216595011225 NADP binding site [chemical binding]; other site 216595011226 catalytic residues [active] 216595011228 PS00070 Aldehyde dehydrogenases cysteine active site. 216595011229 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 216595011231 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 216595011232 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 216595011233 ligand binding site [chemical binding]; other site 216595011234 1 probable transmembrane helix predicted for PFLU2372 by TMHMM2.0 at aa 7-29 216595011236 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 216595011237 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 216595011238 Walker A/P-loop; other site 216595011239 ATP binding site [chemical binding]; other site 216595011240 Q-loop/lid; other site 216595011241 ABC transporter signature motif; other site 216595011242 Walker B; other site 216595011243 D-loop; other site 216595011244 H-loop/switch region; other site 216595011245 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 216595011247 PS00017 ATP/GTP-binding site motif A (P-loop). 216595011248 PS00211 ABC transporters family signature. 216595011250 PS00211 ABC transporters family signature. 216595011251 PS00213 Lipocalin signature. 216595011252 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216595011253 TM-ABC transporter signature motif; other site 216595011254 10 probable transmembrane helices predicted for PFLU2374 by TMHMM2.0 at aa 20-42, 52-71, 78-95, 101-123, 128-150, 170-192, 221-243, 248-270, 277-294 and 299-316 216595011256 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 216595011257 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 216595011258 active site 216595011259 catalytic residues [active] 216595011261 PS00545 Aldose 1-epimerase putative active site. 216595011262 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216595011263 classical (c) SDRs; Region: SDR_c; cd05233 216595011264 NAD(P) binding site [chemical binding]; other site 216595011265 active site 216595011267 PS00061 Short-chain dehydrogenases/reductases family signature. 216595011268 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 216595011269 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 216595011270 C-terminal domain interface [polypeptide binding]; other site 216595011271 GSH binding site (G-site) [chemical binding]; other site 216595011272 dimer interface [polypeptide binding]; other site 216595011273 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 216595011274 dimer interface [polypeptide binding]; other site 216595011275 N-terminal domain interface [polypeptide binding]; other site 216595011276 putative substrate binding pocket (H-site) [chemical binding]; other site 216595011278 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 216595011279 active site 216595011280 SUMO-1 interface [polypeptide binding]; other site 216595011282 Cupin domain; Region: Cupin_2; cl09118 216595011283 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595011284 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216595011285 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595011287 PS00041 Bacterial regulatory proteins, araC family signature. 216595011289 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595011290 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 216595011291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 216595011292 12 probable transmembrane helices predicted for PFLU2381 by TMHMM2.0 at aa 21-43, 58-80, 92-114, 119-141, 148-170, 180-199, 220-242, 257-279, 286-308, 312-334, 347-369 and 374-396 216595011294 putative S-transferase; Provisional; Region: PRK11752 216595011295 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_N_Ure2p_like; cd03048 216595011296 C-terminal domain interface [polypeptide binding]; other site 216595011297 GSH binding site (G-site) [chemical binding]; other site 216595011298 dimer interface [polypeptide binding]; other site 216595011299 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 216595011300 dimer interface [polypeptide binding]; other site 216595011301 N-terminal domain interface [polypeptide binding]; other site 216595011302 active site 216595011305 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 216595011306 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 216595011307 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 216595011308 putative ligand binding site [chemical binding]; other site 216595011310 PS00017 ATP/GTP-binding site motif A (P-loop). 216595011311 1 probable transmembrane helix predicted for PFLU2383 by TMHMM2.0 at aa 5-27 216595011312 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 216595011314 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 216595011315 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595011316 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 216595011319 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 216595011320 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595011321 Walker A motif; other site 216595011322 ATP binding site [chemical binding]; other site 216595011323 Walker B motif; other site 216595011324 arginine finger; other site 216595011325 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 216595011328 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 216595011329 PS00688 Sigma-54 interaction domain C-terminal part signature. 216595011331 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 216595011332 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216595011333 DNA binding site [nucleotide binding] 216595011334 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 216595011335 putative ligand binding site [chemical binding]; other site 216595011336 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 216595011337 This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase); Region: Rhizopine-oxygenase-like; cd03511 216595011338 putative di-iron ligands [ion binding]; other site 216595011339 3 probable transmembrane helices predicted for PFLU2390 by TMHMM2.0 at aa 58-77, 81-98 and 217-239 216595011341 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise...; Region: Rieske_RO_ferredoxin; cd03528 216595011342 [2Fe-2S] cluster binding site [ion binding]; other site 216595011344 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 216595011345 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595011348 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 216595011350 Bacitracin resistance protein BacA; Region: BacA; cl00858 216595011352 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 216595011353 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 216595011354 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 216595011355 conserved cys residue [active] 216595011356 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595011358 PS00041 Bacterial regulatory proteins, araC family signature. 216595011360 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216595011361 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216595011363 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 216595011364 potential catalytic triad [active] 216595011365 conserved cys residue [active] 216595011367 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 216595011368 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 216595011369 FMN binding site [chemical binding]; other site 216595011370 active site 216595011371 substrate binding site [chemical binding]; other site 216595011372 catalytic residue [active] 216595011374 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 216595011376 Integrase core domain; Region: rve; cl01316 216595011378 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 216595011379 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 216595011380 NAD(P) binding site [chemical binding]; other site 216595011383 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595011384 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216595011385 putative substrate translocation pore; other site 216595011387 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595011388 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595011389 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595011390 dimerization interface [polypeptide binding]; other site 216595011393 DoxX; Region: DoxX; cl00976 216595011394 4 probable transmembrane helices predicted for PFLU2406 by TMHMM2.0 at aa 24-43, 63-85, 90-107 and 117-139 216595011396 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595011397 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216595011398 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595011400 1 probable transmembrane helix predicted for PFLU2409 by TMHMM2.0 at aa 12-34 216595011401 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 216595011402 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 216595011403 putative NAD(P) binding site [chemical binding]; other site 216595011404 putative substrate binding site [chemical binding]; other site 216595011405 catalytic Zn binding site [ion binding]; other site 216595011406 structural Zn binding site [ion binding]; other site 216595011407 dimer interface [polypeptide binding]; other site 216595011409 PS00190 Cytochrome c family heme-binding site signature. 216595011410 PS00059 Zinc-containing alcohol dehydrogenases signature. 216595011412 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 216595011413 Secretin and TonB N terminus short domain; Region: STN; cl06624 216595011414 1 probable transmembrane helix predicted for PFLU2412 by TMHMM2.0 at aa 12-34 216595011416 RNA polymerase sigma factor; Reviewed; Region: PRK12527 216595011418 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 216595011419 FecR protein; Region: FecR; pfam04773 216595011421 type II secretion system secreton cluster 1 216595011422 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 216595011423 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 216595011424 Pseudopilin GspJ; Region: GspJ; pfam11612 216595011426 1 probable transmembrane helix predicted for PFLU2415 by TMHMM2.0 at aa 7-29 216595011427 PS00409 Prokaryotic N-terminal methylation site. 216595011428 general secretion pathway protein H; Region: typeII_sec_gspH; TIGR01708 216595011429 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 216595011430 1 probable transmembrane helix predicted for PFLU2416 by TMHMM2.0 at aa 49-71 216595011432 PS00409 Prokaryotic N-terminal methylation site. 216595011433 1 probable transmembrane helix predicted for PFLU2417 by TMHMM2.0 at aa 7-29 216595011434 Bacterial type II secretion system protein I/J; Region: GSPII_IJ; pfam02501 216595011436 1 probable transmembrane helix predicted for PFLU2418 by TMHMM2.0 at aa 12-34 216595011438 PS00409 Prokaryotic N-terminal methylation site. 216595011439 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 216595011440 general secretion pathway protein G; Region: typeII_sec_gspG; TIGR01710 216595011441 Bacterial type II secretion system protein G; Region: GSPII_G; pfam08334 216595011443 PS00409 Prokaryotic N-terminal methylation site. 216595011444 1 probable transmembrane helix predicted for PFLU2419 by TMHMM2.0 at aa 20-42 216595011446 General secretion pathway protein K; Region: GspK; pfam03934 216595011448 1 probable transmembrane helix predicted for PFLU2420 by TMHMM2.0 at aa 13-35 216595011449 general secretion pathway protein L; Region: typeII_sec_gspL; TIGR01709 216595011450 GspL periplasmic domain; Region: GspL_C; cl14909 216595011452 General secretion pathway, M protein; Region: GspM; cl01222 216595011454 1 probable transmembrane helix predicted for PFLU2422 by TMHMM2.0 at aa 39-61 216595011455 general secretion pathway protein D; Region: type_II_gspD; TIGR02517 216595011456 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 216595011457 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 216595011458 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 216595011459 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 216595011460 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595011465 general secretory pathway protein E; Region: type_II_gspE; TIGR02533 216595011466 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 216595011467 Walker A motif; other site 216595011468 ATP binding site [chemical binding]; other site 216595011469 Walker B motif; other site 216595011471 PS00017 ATP/GTP-binding site motif A (P-loop). 216595011472 PS00662 Bacterial type II secretion system protein E signature. 216595011473 general secretion pathway protein F; Region: GspF; TIGR02120 216595011474 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 216595011475 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 216595011477 3 probable transmembrane helices predicted for PFLU2425 by TMHMM2.0 at aa 168-190, 219-241 and 374-396 216595011479 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595011480 haemagglutination activity domain; Region: Haemagg_act; cl05436 216595011481 Filamentous haemagglutinin family outer membrane protein; Region: DUF3739; pfam12545 216595011483 Transposase domain (DUF772); Region: DUF772; cl12084 216595011484 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 216595011485 Surface antigen; Region: Bac_surface_Ag; cl03097 216595011488 Domain of unknown function (DUF2341); Region: DUF2341; pfam10102 216595011489 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 216595011490 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 216595011491 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 216595011492 4 probable transmembrane helices predicted for PFLU2434 by TMHMM2.0 at aa 5-24, 365-387, 491-513 and 528-550 216595011495 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 216595011497 1 probable transmembrane helix predicted for PFLU2435 by TMHMM2.0 at aa 15-37 216595011498 Gram-negative bacterial tonB protein; Region: TonB; cl10048 216595011499 1 probable transmembrane helix predicted for PFLU2436 by TMHMM2.0 at aa 21-38 216595011500 PS00116 DNA polymerase family B signature. 216595011501 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 216595011502 PPIC-type PPIASE domain; Region: Rotamase; cl08278 216595011504 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595011505 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595011506 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595011508 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595011509 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595011510 dimerization interface [polypeptide binding]; other site 216595011513 PS00044 Bacterial regulatory proteins, lysR family signature. 216595011514 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 216595011515 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 216595011517 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 216595011519 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595011520 Predicted esterase [General function prediction only]; Region: COG0400 216595011522 hypothetical protein; Provisional; Region: PRK11615 216595011523 PS00017 ATP/GTP-binding site motif A (P-loop). 216595011524 1 probable transmembrane helix predicted for PFLU2447 by TMHMM2.0 at aa 7-24 216595011525 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 216595011526 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 216595011527 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595011530 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 216595011532 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 216595011533 EamA-like transporter family; Region: EamA; cl01037 216595011536 exosortase 1 system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 216595011537 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 216595011538 active site 216595011539 dimer interface [polypeptide binding]; other site 216595011540 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 216595011541 Ligand Binding Site [chemical binding]; other site 216595011542 Molecular Tunnel; other site 216595011545 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 216595011546 enoyl-CoA hydratase; Provisional; Region: PRK08150 216595011547 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 216595011548 substrate binding site [chemical binding]; other site 216595011549 oxyanion hole (OAH) forming residues; other site 216595011550 trimer interface [polypeptide binding]; other site 216595011552 Cupin domain; Region: Cupin_2; cl09118 216595011553 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216595011554 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595011557 PS00041 Bacterial regulatory proteins, araC family signature. 216595011559 Protein of unknown function (DUF726); Region: DUF726; pfam05277 216595011560 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045 216595011561 PS00120 Lipases, serine active site. 216595011563 1 probable transmembrane helix predicted for PFLU2456 by TMHMM2.0 at aa 472-494 216595011564 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 216595011565 11 probable transmembrane helices predicted for PFLU2457 by TMHMM2.0 at aa 30-49, 64-86, 114-136, 140-162, 169-191, 211-233, 261-283, 298-320, 352-369, 379-397 and 417-434 216595011567 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 216595011568 putative active site [active] 216595011570 Phd_YefM; Region: PhdYeFM; cl09153 216595011572 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595011573 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595011574 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 216595011575 putative effector binding pocket; other site 216595011576 dimerization interface [polypeptide binding]; other site 216595011579 PS00044 Bacterial regulatory proteins, lysR family signature. 216595011580 Protein of unknown function, DUF606; Region: DUF606; cl01273 216595011581 5 probable transmembrane helices predicted for PFLU2461 by TMHMM2.0 at aa 19-41, 51-73, 86-108, 112-134 and 141-160 216595011583 Protein of unknown function, DUF606; Region: DUF606; cl01273 216595011584 4 probable transmembrane helices predicted for PFLU2462 by TMHMM2.0 at aa 7-29, 39-61, 81-112 and 127-149 216595011586 Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069 216595011588 Cupin domain; Region: Cupin_2; cl09118 216595011589 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216595011591 PS00041 Bacterial regulatory proteins, araC family signature. 216595011593 Protein of unknown function (DUF1427); Region: DUF1427; cl01771 216595011595 2 probable transmembrane helices predicted for PFLU2468 by TMHMM2.0 at aa 3-20 and 24-41 216595011596 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 216595011597 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 216595011598 putative NAD(P) binding site [chemical binding]; other site 216595011601 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 216595011603 1 probable transmembrane helix predicted for PFLU2470 by TMHMM2.0 at aa 9-31 216595011604 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 216595011606 Cupin domain; Region: Cupin_2; cl09118 216595011607 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216595011608 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595011610 PS00041 Bacterial regulatory proteins, araC family signature. 216595011611 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216595011612 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595011614 sorbitol dehydrogenase; Provisional; Region: PRK07067 216595011615 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595011616 NAD(P) binding site [chemical binding]; other site 216595011617 active site 216595011619 PS00061 Short-chain dehydrogenases/reductases family signature. 216595011620 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 216595011621 PFI-6 216595011622 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 216595011623 NmrA-like family; Region: NmrA; pfam05368 216595011624 NAD(P) binding site [chemical binding]; other site 216595011625 active site lysine 216595011627 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595011629 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 216595011630 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 216595011631 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 216595011634 Nitrate and nitrite sensing; Region: NIT; pfam08376 216595011635 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595011636 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595011637 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595011638 2 probable transmembrane helices predicted for PFLU2486 by TMHMM2.0 at aa 25-44 and 314-336 216595011642 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 216595011643 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 216595011644 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 216595011645 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 216595011646 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 216595011647 DNA binding site [nucleotide binding] 216595011648 active site 216595011650 PS00374 Methylated-DNA--protein-cysteine methyltransferase active site. 216595011652 PS00041 Bacterial regulatory proteins, araC family signature. 216595011654 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 216595011655 tetramer interface [polypeptide binding]; other site 216595011656 active site 216595011657 Mg2+/Mn2+ binding site [ion binding]; other site 216595011658 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 216595011659 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 216595011660 putative ion selectivity filter; other site 216595011661 putative pore gating glutamate residue; other site 216595011662 putative H+/Cl- coupling transport residue; other site 216595011664 PS00044 Bacterial regulatory proteins, lysR family signature. 216595011665 PS00216 Sugar transport proteins signature 1. 216595011667 1 probable transmembrane helix predicted for PFLU2491 by TMHMM2.0 at aa 15-34 216595011669 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 216595011670 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 216595011671 conserved cys residue [active] 216595011672 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595011673 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595011677 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 216595011678 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595011679 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595011680 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595011681 2 probable transmembrane helices predicted for PFLU2496 by TMHMM2.0 at aa 10-32 and 190-212 216595011684 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216595011685 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216595011686 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 216595011687 putative active site [active] 216595011688 heme pocket [chemical binding]; other site 216595011689 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216595011690 putative active site [active] 216595011691 heme pocket [chemical binding]; other site 216595011692 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595011696 Fusaric acid resistance protein family; Region: FUSC; pfam04632 216595011699 PS00287 Cysteine proteases inhibitors signature. 216595011700 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 216595011701 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 216595011702 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 216595011703 conserved cys residue [active] 216595011706 PS00041 Bacterial regulatory proteins, araC family signature. 216595011708 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 216595011709 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 216595011710 conserved cys residue [active] 216595011711 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595011713 PS00041 Bacterial regulatory proteins, araC family signature. 216595011716 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 216595011717 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216595011718 N-terminal plug; other site 216595011719 ligand-binding site [chemical binding]; other site 216595011721 PS01156 TonB-dependent receptor proteins signature 2. 216595011723 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 216595011724 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 216595011725 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 216595011727 IS2 transposase TnpB; Reviewed; Region: PRK09409 216595011728 Integrase core domain; Region: rve; cl01316 216595011730 GAF domain; Region: GAF; cl00853 216595011731 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595011732 dimer interface [polypeptide binding]; other site 216595011733 phosphorylation site [posttranslational modification] 216595011734 sensory histidine kinase CreC; Provisional; Region: PRK11100 216595011735 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595011736 ATP binding site [chemical binding]; other site 216595011737 G-X-G motif; other site 216595011741 transcriptional regulator BetI; Validated; Region: PRK00767 216595011742 C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family include the bacteriophage lambda integrase, the...; Region: INT_REC_C; cd01182 216595011743 DNA binding site [nucleotide binding] 216595011744 Int/Topo IB signature motif; other site 216595011745 active site 216595011746 catalytic residues [active] 216595011748 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 216595011749 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl12019 216595011750 active site 216595011752 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595011753 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 216595011754 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 216595011755 homodimer interface [polypeptide binding]; other site 216595011756 NAD binding pocket [chemical binding]; other site 216595011757 ATP binding pocket [chemical binding]; other site 216595011758 Mg binding site [ion binding]; other site 216595011759 active-site loop [active] 216595011761 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595011763 1 probable transmembrane helix predicted for PFLU2522 by TMHMM2.0 at aa 5-27 216595011764 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 216595011765 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 216595011766 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 216595011768 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 216595011769 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595011770 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 216595011773 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 216595011774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595011775 dimer interface [polypeptide binding]; other site 216595011776 conserved gate region; other site 216595011777 putative PBP binding loops; other site 216595011778 ABC-ATPase subunit interface; other site 216595011780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595011781 dimer interface [polypeptide binding]; other site 216595011782 conserved gate region; other site 216595011783 putative PBP binding loops; other site 216595011784 ABC-ATPase subunit interface; other site 216595011786 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595011787 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 216595011788 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595011789 Walker A/P-loop; other site 216595011790 ATP binding site [chemical binding]; other site 216595011791 Q-loop/lid; other site 216595011792 ABC transporter signature motif; other site 216595011793 Walker B; other site 216595011794 D-loop; other site 216595011795 H-loop/switch region; other site 216595011796 TOBE domain; Region: TOBE_2; cl01440 216595011799 PS00211 ABC transporters family signature. 216595011800 PS00017 ATP/GTP-binding site motif A (P-loop). 216595011801 Transcriptional regulator [Transcription]; Region: IclR; COG1414 216595011802 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595011803 Bacterial transcriptional regulator; Region: IclR; pfam01614 216595011806 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216595011807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595011808 active site 216595011809 phosphorylation site [posttranslational modification] 216595011810 intermolecular recognition site; other site 216595011811 dimerization interface [polypeptide binding]; other site 216595011812 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 216595011813 DNA binding residues [nucleotide binding] 216595011814 dimerization interface [polypeptide binding]; other site 216595011816 PS00622 Bacterial regulatory proteins, luxR family signature. 216595011818 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 216595011819 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595011820 DNA-binding site [nucleotide binding]; DNA binding site 216595011821 UTRA domain; Region: UTRA; cl01230 216595011823 PS00043 Bacterial regulatory proteins, gntR family signature. 216595011825 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 216595011826 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595011827 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595011830 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 216595011832 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 216595011833 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 216595011834 Predicted amidohydrolase [General function prediction only]; Region: COG0388 216595011835 multimer interface [polypeptide binding]; other site 216595011836 active site 216595011837 catalytic triad [active] 216595011838 dimer interface [polypeptide binding]; other site 216595011840 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595011841 Walker A motif; other site 216595011842 ATP binding site [chemical binding]; other site 216595011843 Walker B motif; other site 216595011845 PS00017 ATP/GTP-binding site motif A (P-loop). 216595011846 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 216595011847 MatE; Region: MatE; cl10513 216595011848 MatE; Region: MatE; cl10513 216595011849 12 probable transmembrane helices predicted for PFLU2538 by TMHMM2.0 at aa 12-34, 54-76, 89-111, 138-157, 164-186, 191-213, 245-267, 287-309, 322-344, 359-381, 388-410 and 420-442 216595011852 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216595011853 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216595011855 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216595011856 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595011857 11 probable transmembrane helices predicted for PFLU2540 by TMHMM2.0 at aa 50-72, 79-101, 116-135, 142-161, 203-225, 245-267, 282-304, 316-334, 339-361, 374-396 and 401-423 216595011859 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 216595011860 HicB family; Region: HicB; pfam05534 216595011862 Condensation domain; Region: Condensation; cl09290 216595011863 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 216595011864 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595011865 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595011866 Phosphopantetheine attachment site; Region: PP-binding; cl09936 216595011867 Condensation domain; Region: Condensation; cl09290 216595011868 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 216595011869 Condensation domain; Region: Condensation; cl09290 216595011870 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216595011871 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595011872 Phosphopantetheine attachment site; Region: PP-binding; cl09936 216595011873 Condensation domain; Region: Condensation; cl09290 216595011874 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 216595011875 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595011876 Phosphopantetheine attachment site; Region: PP-binding; cl09936 216595011877 Condensation domain; Region: Condensation; cl09290 216595011878 peptide synthase; Provisional; Region: PRK12316 216595011879 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595011880 Phosphopantetheine attachment site; Region: PP-binding; cl09936 216595011882 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 216595011884 PS00455 Putative AMP-binding domain signature. 216595011886 PS00012 Phosphopantetheine attachment site. 216595011889 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595011891 PS00455 Putative AMP-binding domain signature. 216595011895 PS00455 Putative AMP-binding domain signature. 216595011896 PS00044 Bacterial regulatory proteins, lysR family signature. 216595011898 PS00012 Phosphopantetheine attachment site. 216595011900 PS00041 Bacterial regulatory proteins, araC family signature. 216595011902 PS00455 Putative AMP-binding domain signature. 216595011904 PS00012 Phosphopantetheine attachment site. 216595011905 peptide synthase; Provisional; Region: PRK12467 216595011906 Condensation domain; Region: Condensation; cl09290 216595011907 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595011908 Phosphopantetheine attachment site; Region: PP-binding; cl09936 216595011909 Condensation domain; Region: Condensation; cl09290 216595011910 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595011911 Phosphopantetheine attachment site; Region: PP-binding; cl09936 216595011912 Condensation domain; Region: Condensation; cl09290 216595011913 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 216595011914 Condensation domain; Region: Condensation; cl09290 216595011915 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595011916 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595011917 Phosphopantetheine attachment site; Region: PP-binding; cl09936 216595011920 PS00455 Putative AMP-binding domain signature. 216595011922 PS00012 Phosphopantetheine attachment site. 216595011925 PS00455 Putative AMP-binding domain signature. 216595011927 PS00012 Phosphopantetheine attachment site. 216595011931 PS00455 Putative AMP-binding domain signature. 216595011934 Secretin and TonB N terminus short domain; Region: STN; cl06624 216595011935 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 216595011936 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216595011937 N-terminal plug; other site 216595011938 ligand-binding site [chemical binding]; other site 216595011940 PS01156 TonB-dependent receptor proteins signature 2. 216595011943 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 216595011944 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 216595011945 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with...; Region: ABCC_MRP_Like; cd03228 216595011946 Walker A/P-loop; other site 216595011947 ATP binding site [chemical binding]; other site 216595011948 Q-loop/lid; other site 216595011949 ABC transporter signature motif; other site 216595011950 Walker B; other site 216595011951 D-loop; other site 216595011952 H-loop/switch region; other site 216595011954 PS00017 ATP/GTP-binding site motif A (P-loop). 216595011956 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 216595011957 catalytic site [active] 216595011958 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 216595011960 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 216595011961 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 216595011962 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 216595011963 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216595011964 catalytic residue [active] 216595011966 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 216595011967 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics...; Region: rDP_like; cd01301 216595011968 active site 216595011969 dimer interface [polypeptide binding]; other site 216595011971 1 probable transmembrane helix predicted for PFLU2550 by TMHMM2.0 at aa 12-34 216595011972 1 probable transmembrane helix predicted for PFLU2551 by TMHMM2.0 at aa 7-26 216595011973 Condensation domain; Region: Condensation; cl09290 216595011974 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595011975 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216595011976 Phosphopantetheine attachment site; Region: PP-binding; cl09936 216595011977 peptide synthase; Validated; Region: PRK05691 216595011978 Condensation domain; Region: Condensation; cl09290 216595011979 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595011980 Phosphopantetheine attachment site; Region: PP-binding; cl09936 216595011981 Condensation domain; Region: Condensation; cl09290 216595011982 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595011983 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216595011984 Phosphopantetheine attachment site; Region: PP-binding; cl09936 216595011985 Condensation domain; Region: Condensation; cl09290 216595011986 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595011987 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216595011988 Phosphopantetheine attachment site; Region: PP-binding; cl09936 216595011991 PS00455 Putative AMP-binding domain signature. 216595011993 PS00012 Phosphopantetheine attachment site. 216595011995 PS00659 Glycosyl hydrolases family 5 signature. 216595011997 PS00455 Putative AMP-binding domain signature. 216595012001 PS00455 Putative AMP-binding domain signature. 216595012005 PS00455 Putative AMP-binding domain signature. 216595012007 Condensation domain; Region: Condensation; cl09290 216595012008 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 216595012009 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216595012010 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595012011 Phosphopantetheine attachment site; Region: PP-binding; cl09936 216595012012 Condensation domain; Region: Condensation; cl09290 216595012013 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 216595012014 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595012015 Phosphopantetheine attachment site; Region: PP-binding; cl09936 216595012016 peptide synthase; Provisional; Region: PRK12467 216595012017 Condensation domain; Region: Condensation; cl09290 216595012018 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595012019 Phosphopantetheine attachment site; Region: PP-binding; cl09936 216595012020 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 216595012021 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 216595012024 PS00455 Putative AMP-binding domain signature. 216595012026 PS00012 Phosphopantetheine attachment site. 216595012029 PS00455 Putative AMP-binding domain signature. 216595012033 PS00455 Putative AMP-binding domain signature. 216595012034 PS00070 Aldehyde dehydrogenases cysteine active site. 216595012036 PS00012 Phosphopantetheine attachment site. 216595012039 PS00120 Lipases, serine active site. 216595012040 macrolide transporter subunit MacA; Provisional; Region: PRK11578 216595012041 1 probable transmembrane helix predicted for PFLU2555 by TMHMM2.0 at aa 51-70 216595012043 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 216595012044 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 216595012045 Walker A/P-loop; other site 216595012046 ATP binding site [chemical binding]; other site 216595012047 Q-loop/lid; other site 216595012048 ABC transporter signature motif; other site 216595012049 Walker B; other site 216595012050 D-loop; other site 216595012051 H-loop/switch region; other site 216595012052 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 216595012053 FtsX-like permease family; Region: FtsX; pfam02687 216595012055 PS00017 ATP/GTP-binding site motif A (P-loop). 216595012056 PS00211 ABC transporters family signature. 216595012058 3 probable transmembrane helices predicted for PFLU2556 by TMHMM2.0 at aa 531-553, 576-598 and 613-635 216595012059 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595012061 methionine gamma-lyase; Provisional; Region: PRK07503 216595012062 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 216595012063 homodimer interface [polypeptide binding]; other site 216595012064 substrate-cofactor binding pocket; other site 216595012065 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595012066 catalytic residue [active] 216595012068 PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. 216595012069 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 216595012070 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595012072 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 216595012073 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 216595012075 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 216595012076 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216595012077 N-terminal plug; other site 216595012078 ligand-binding site [chemical binding]; other site 216595012081 transcriptional regulator EutR; Provisional; Region: PRK10130 216595012083 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 216595012084 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595012086 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 216595012087 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 216595012089 1 probable transmembrane helix predicted for PFLU2566 by TMHMM2.0 at aa 13-35 216595012090 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 216595012091 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595012092 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 216595012093 dimerization interface [polypeptide binding]; other site 216595012094 substrate binding pocket [chemical binding]; other site 216595012097 PS00044 Bacterial regulatory proteins, lysR family signature. 216595012098 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 216595012099 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216595012100 active site 216595012101 catalytic tetrad [active] 216595012103 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216595012104 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595012105 NAD(P) binding site [chemical binding]; other site 216595012106 active site 216595012108 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 216595012109 putative hydrophobic ligand binding site [chemical binding]; other site 216595012110 protein interface [polypeptide binding]; other site 216595012111 gate; other site 216595012113 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216595012114 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595012115 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595012116 dimer interface [polypeptide binding]; other site 216595012117 phosphorylation site [posttranslational modification] 216595012118 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595012119 ATP binding site [chemical binding]; other site 216595012120 Mg2+ binding site [ion binding]; other site 216595012121 G-X-G motif; other site 216595012125 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216595012126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595012127 active site 216595012128 phosphorylation site [posttranslational modification] 216595012129 intermolecular recognition site; other site 216595012130 dimerization interface [polypeptide binding]; other site 216595012131 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 216595012132 DNA binding site [nucleotide binding] 216595012135 4 probable transmembrane helices predicted for PFLU2573 by TMHMM2.0 at aa 69-91, 111-133, 154-176 and 304-326 216595012136 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 216595012137 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 216595012138 putative active site [active] 216595012141 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 216595012142 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 216595012143 substrate binding site [chemical binding]; other site 216595012144 ATP binding site [chemical binding]; other site 216595012145 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 216595012147 PS00584 pfkB family of carbohydrate kinases signature 2. 216595012148 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 216595012150 PS00215 Mitochondrial energy transfer proteins signature. 216595012151 KduI/IolB family; Region: KduI; cl01508 216595012153 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 216595012155 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 216595012156 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 216595012157 PYR/PP interface [polypeptide binding]; other site 216595012158 dimer interface [polypeptide binding]; other site 216595012159 TPP binding site [chemical binding]; other site 216595012160 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 216595012161 TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 216595012162 TPP-binding site; other site 216595012165 PS00017 ATP/GTP-binding site motif A (P-loop). 216595012167 PS00187 Thiamine pyrophosphate enzymes signature. 216595012168 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 216595012169 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595012170 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 216595012173 putative oxidoreductase; Provisional; Region: PRK11579 216595012174 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595012175 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 216595012178 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 216595012179 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 216595012180 putative ligand binding site [chemical binding]; other site 216595012182 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 216595012183 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 216595012184 Walker A/P-loop; other site 216595012185 ATP binding site [chemical binding]; other site 216595012186 Q-loop/lid; other site 216595012187 ABC transporter signature motif; other site 216595012188 Walker B; other site 216595012189 D-loop; other site 216595012190 H-loop/switch region; other site 216595012191 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 216595012193 PS00017 ATP/GTP-binding site motif A (P-loop). 216595012195 PS00211 ABC transporters family signature. 216595012196 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 216595012197 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216595012198 TM-ABC transporter signature motif; other site 216595012199 8 probable transmembrane helices predicted for PFLU2585 by TMHMM2.0 at aa 26-48, 58-80, 87-104, 119-136, 141-163, 183-205, 235-257 and 290-312 216595012201 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 216595012203 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595012204 1 probable transmembrane helix predicted for PFLU2587 by TMHMM2.0 at aa 56-78 216595012206 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 216595012207 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 216595012208 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 216595012210 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 216595012211 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216595012212 N-terminal plug; other site 216595012213 ligand-binding site [chemical binding]; other site 216595012215 PS01156 TonB-dependent receptor proteins signature 2. 216595012217 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595012218 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 216595012219 1 probable transmembrane helix predicted for PFLU2594 by TMHMM2.0 at aa 15-37 216595012220 4 probable transmembrane helices predicted for PFLU2595 by TMHMM2.0 at aa 5-27, 56-78, 85-104 and 126-144 216595012221 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 216595012222 RHS Repeat; Region: RHS_repeat; cl11982 216595012223 RHS Repeat; Region: RHS_repeat; cl11982 216595012224 RHS Repeat; Region: RHS_repeat; cl11982 216595012225 RHS protein; Region: RHS; pfam03527 216595012226 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 216595012240 1 probable transmembrane helix predicted for PFLU2597 by TMHMM2.0 at aa 285-307 216595012241 Secretin and TonB N terminus short domain; Region: STN; cl06624 216595012242 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 216595012243 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216595012244 N-terminal plug; other site 216595012245 ligand-binding site [chemical binding]; other site 216595012249 1 probable transmembrane helix predicted for PFLU2599 by TMHMM2.0 at aa 7-26 216595012250 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 216595012251 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595012252 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 216595012253 dimerization interface [polypeptide binding]; other site 216595012256 PS00044 Bacterial regulatory proteins, lysR family signature. 216595012257 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 216595012258 Putative ammonia monooxygenase; Region: AmoA; pfam05145 216595012259 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 216595012260 6 probable transmembrane helices predicted for PFLU2601 by TMHMM2.0 at aa 7-29, 82-104, 148-170, 174-193, 259-281 and 301-323 216595012262 PS00435 Peroxidases proximal heme-ligand signature. 216595012263 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 216595012265 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216595012266 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595012268 PS00041 Bacterial regulatory proteins, araC family signature. 216595012270 1 probable transmembrane helix predicted for PFLU2605 by TMHMM2.0 at aa 15-33 216595012271 low G+C content region (38.77%) 216595012272 PAS fold; Region: PAS_3; pfam08447 216595012273 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 216595012274 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216595012275 metal binding site [ion binding]; metal-binding site 216595012276 active site 216595012277 I-site; other site 216595012280 1 probable transmembrane helix predicted for PFLU2607 by TMHMM2.0 at aa 34-53 216595012281 RNA polymerase sigma factor; Reviewed; Region: PRK05602 216595012282 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216595012285 1 probable transmembrane helix predicted for PFLU2610 by TMHMM2.0 at aa 85-107 216595012286 Predicted integral membrane protein [Function unknown]; Region: COG5612 216595012287 1 probable transmembrane helix predicted for PFLU2611 by TMHMM2.0 at aa 9-31 216595012288 SCP-2 sterol transfer family; Region: SCP2; cl01225 216595012290 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 216595012291 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 216595012292 catalytic core [active] 216595012294 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 216595012295 putative inner membrane peptidase; Provisional; Region: PRK11778 216595012296 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 216595012297 tandem repeat interface [polypeptide binding]; other site 216595012298 oligomer interface [polypeptide binding]; other site 216595012299 active site residues [active] 216595012301 1 probable transmembrane helix predicted for PFLU2614 by TMHMM2.0 at aa 7-29 216595012303 Integral membrane protein TerC family; Region: TerC; cl10468 216595012304 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 216595012305 Transporter associated domain; Region: CorC_HlyC; cl08393 216595012307 7 probable transmembrane helices predicted for PFLU2615 by TMHMM2.0 at aa 13-35, 48-70, 85-99, 120-139, 154-171, 178-200 and 205-227 216595012310 low G+C content region (37.69%) 216595012311 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 216595012312 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595012313 substrate binding pocket [chemical binding]; other site 216595012314 membrane-bound complex binding site; other site 216595012315 hinge residues; other site 216595012317 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 216595012318 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595012319 dimer interface [polypeptide binding]; other site 216595012320 conserved gate region; other site 216595012321 putative PBP binding loops; other site 216595012322 ABC-ATPase subunit interface; other site 216595012324 4 probable transmembrane helices predicted for PFLU2618 by TMHMM2.0 at aa 20-42, 55-77, 92-114 and 187-209 216595012325 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216595012326 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595012327 dimer interface [polypeptide binding]; other site 216595012328 conserved gate region; other site 216595012329 putative PBP binding loops; other site 216595012330 ABC-ATPase subunit interface; other site 216595012332 3 probable transmembrane helices predicted for PFLU2619 by TMHMM2.0 at aa 26-48, 69-91 and 191-213 216595012333 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595012334 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 216595012335 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 216595012336 Walker A/P-loop; other site 216595012337 ATP binding site [chemical binding]; other site 216595012338 Q-loop/lid; other site 216595012339 ABC transporter signature motif; other site 216595012340 Walker B; other site 216595012341 D-loop; other site 216595012342 H-loop/switch region; other site 216595012344 PS00017 ATP/GTP-binding site motif A (P-loop). 216595012345 PS00211 ABC transporters family signature. 216595012346 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 216595012347 homotrimer interaction site [polypeptide binding]; other site 216595012348 putative active site [active] 216595012350 Transcriptional regulator [Transcription]; Region: IclR; COG1414 216595012351 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595012352 Bacterial transcriptional regulator; Region: IclR; pfam01614 216595012355 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 216595012356 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 216595012357 dimer interface [polypeptide binding]; other site 216595012358 active site 216595012359 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 216595012360 substrate binding site [chemical binding]; other site 216595012361 catalytic residue [active] 216595012362 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 216595012363 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 216595012364 substrate binding site [chemical binding]; other site 216595012365 ATP binding site [chemical binding]; other site 216595012367 PS00584 pfkB family of carbohydrate kinases signature 2. 216595012368 PPIC-type PPIASE domain; Region: Rotamase; cl08278 216595012370 PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature. 216595012371 putative diguanylate cyclase; Provisional; Region: PRK09776 216595012372 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 216595012373 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 216595012374 PAS fold; Region: PAS_4; pfam08448 216595012375 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 216595012376 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595012377 dimer interface [polypeptide binding]; other site 216595012378 phosphorylation site [posttranslational modification] 216595012379 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595012380 ATP binding site [chemical binding]; other site 216595012381 Mg2+ binding site [ion binding]; other site 216595012382 G-X-G motif; other site 216595012383 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595012384 Response regulator receiver domain; Region: Response_reg; pfam00072 216595012385 active site 216595012386 phosphorylation site [posttranslational modification] 216595012387 intermolecular recognition site; other site 216595012388 dimerization interface [polypeptide binding]; other site 216595012395 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 216595012396 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 216595012397 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595012399 PS00455 Putative AMP-binding domain signature. 216595012400 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 216595012401 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 216595012402 NAD binding site [chemical binding]; other site 216595012403 homotetramer interface [polypeptide binding]; other site 216595012404 homodimer interface [polypeptide binding]; other site 216595012405 substrate binding site [chemical binding]; other site 216595012406 active site 216595012408 PS00061 Short-chain dehydrogenases/reductases family signature. 216595012409 Citrate transporter; Region: CitMHS; pfam03600 216595012411 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 216595012412 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 216595012413 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595012414 Walker B motif; other site 216595012415 arginine finger; other site 216595012416 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 216595012418 PS00688 Sigma-54 interaction domain C-terminal part signature. 216595012420 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 216595012421 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 216595012423 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 216595012424 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 216595012425 Walker A/P-loop; other site 216595012426 ATP binding site [chemical binding]; other site 216595012427 Q-loop/lid; other site 216595012428 ABC transporter signature motif; other site 216595012429 Walker B; other site 216595012430 D-loop; other site 216595012431 H-loop/switch region; other site 216595012432 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216595012433 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 216595012434 Walker A/P-loop; other site 216595012435 ATP binding site [chemical binding]; other site 216595012436 Q-loop/lid; other site 216595012437 ABC transporter signature motif; other site 216595012438 Walker B; other site 216595012439 D-loop; other site 216595012440 H-loop/switch region; other site 216595012441 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216595012444 PS00211 ABC transporters family signature. 216595012445 PS00017 ATP/GTP-binding site motif A (P-loop). 216595012448 PS00211 ABC transporters family signature. 216595012449 PS00017 ATP/GTP-binding site motif A (P-loop). 216595012450 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 216595012451 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595012452 dimer interface [polypeptide binding]; other site 216595012453 conserved gate region; other site 216595012454 putative PBP binding loops; other site 216595012455 ABC-ATPase subunit interface; other site 216595012457 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595012458 dimer interface [polypeptide binding]; other site 216595012459 conserved gate region; other site 216595012460 putative PBP binding loops; other site 216595012461 ABC-ATPase subunit interface; other site 216595012463 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 216595012464 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 216595012465 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 216595012467 1 probable transmembrane helix predicted for PFLU2634 by TMHMM2.0 at aa 21-43 216595012468 PPIC-type PPIASE domain; Region: Rotamase; cl08278 216595012470 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 216595012471 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 216595012472 Walker A/P-loop; other site 216595012473 ATP binding site [chemical binding]; other site 216595012474 Q-loop/lid; other site 216595012475 ABC transporter signature motif; other site 216595012476 Walker B; other site 216595012477 D-loop; other site 216595012478 H-loop/switch region; other site 216595012479 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216595012480 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 216595012481 Walker A/P-loop; other site 216595012482 ATP binding site [chemical binding]; other site 216595012483 Q-loop/lid; other site 216595012484 ABC transporter signature motif; other site 216595012485 Walker B; other site 216595012486 D-loop; other site 216595012487 H-loop/switch region; other site 216595012488 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216595012491 PS00211 ABC transporters family signature. 216595012492 PS00017 ATP/GTP-binding site motif A (P-loop). 216595012495 PS00211 ABC transporters family signature. 216595012496 PS00017 ATP/GTP-binding site motif A (P-loop). 216595012497 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 216595012498 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595012499 dimer interface [polypeptide binding]; other site 216595012500 conserved gate region; other site 216595012501 putative PBP binding loops; other site 216595012502 ABC-ATPase subunit interface; other site 216595012504 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595012505 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216595012506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595012507 dimer interface [polypeptide binding]; other site 216595012508 conserved gate region; other site 216595012509 putative PBP binding loops; other site 216595012510 ABC-ATPase subunit interface; other site 216595012512 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 216595012513 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 216595012515 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 216595012516 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 216595012518 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 216595012519 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 216595012520 N-acetyl-D-glucosamine binding site [chemical binding]; other site 216595012521 catalytic residue [active] 216595012522 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 216595012523 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 216595012524 putative peptidoglycan binding site; other site 216595012528 PS00922 Prokaryotic transglycosylases signature. 216595012530 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595012531 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 216595012533 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 216595012534 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 216595012535 RNA/DNA hybrid binding site [nucleotide binding]; other site 216595012536 active site 216595012538 Proteobacterial; Region: dnaQ_proteo; TIGR01406 216595012539 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 216595012540 active site 216595012541 substrate binding site [chemical binding]; other site 216595012542 catalytic site [active] 216595012544 arginine decarboxylase; Provisional; Region: PRK15029 216595012545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 216595012546 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and...; Region: Orn_deC_like; cd00615 216595012547 homodimer interface [polypeptide binding]; other site 216595012548 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595012549 catalytic residue [active] 216595012550 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 216595012553 PS00703 Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site. 216595012555 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216595012556 Coenzyme A binding pocket [chemical binding]; other site 216595012558 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595012559 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595012560 dimerization interface [polypeptide binding]; other site 216595012562 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 216595012564 pyruvate dehydrogenase; Provisional; Region: PRK09124 216595012565 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 216595012566 PYR/PP interface [polypeptide binding]; other site 216595012567 tetramer interface [polypeptide binding]; other site 216595012568 dimer interface [polypeptide binding]; other site 216595012569 TPP binding site [chemical binding]; other site 216595012570 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 216595012571 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX...; Region: TPP_POX; cd02014 216595012572 TPP-binding site [chemical binding]; other site 216595012574 PS00187 Thiamine pyrophosphate enzymes signature. 216595012577 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 216595012578 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 216595012579 putative active site [active] 216595012580 putative FMN binding site [chemical binding]; other site 216595012581 putative substrate binding site [chemical binding]; other site 216595012582 putative catalytic residue [active] 216595012584 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 216595012585 DNA binding residues [nucleotide binding] 216595012586 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 216595012588 PS00552 Bacterial regulatory proteins, merR family signature. 216595012590 Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526 216595012592 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 216595012593 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 216595012594 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 216595012599 1 probable transmembrane helix predicted for PFLU2658 by TMHMM2.0 at aa 70-89 216595012600 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 216595012603 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 216595012604 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105 216595012605 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 216595012606 substrate binding pocket [chemical binding]; other site 216595012607 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 216595012608 B12 binding site [chemical binding]; other site 216595012609 cobalt ligand [ion binding]; other site 216595012610 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 216595012616 Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934 216595012617 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595012619 PS00190 Cytochrome c family heme-binding site signature. 216595012620 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 216595012621 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 216595012622 NifU-like domain; Region: NifU; cl00484 216595012625 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 216595012627 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595012628 PS00839 Uroporphyrin-III C-methyltransferase signature 1. 216595012629 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 216595012631 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 216595012632 Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723 216595012633 1 probable transmembrane helix predicted for PFLU2668 by TMHMM2.0 at aa 21-43 216595012634 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595012635 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 216595012636 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 216595012637 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 216595012639 PS00017 ATP/GTP-binding site motif A (P-loop). 216595012641 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 216595012644 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595012645 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 216595012646 Walker A motif; other site 216595012647 ATP binding site [chemical binding]; other site 216595012648 Walker B motif; other site 216595012649 arginine finger; other site 216595012651 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 216595012652 metal ion-dependent adhesion site (MIDAS); other site 216595012653 Domain of unknown function (DUF1853); Region: DUF1853; cl01545 216595012655 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 216595012656 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 216595012658 Pseudomonas aeruginosa PA3087 and related proteins, metallophosphatase domain; Region: MPP_PA3087; cd07413 216595012659 active site 216595012660 metal binding site [ion binding]; metal-binding site 216595012662 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 216595012663 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595012664 ATP binding site [chemical binding]; other site 216595012665 Walker B motif; other site 216595012666 arginine finger; other site 216595012668 PS00017 ATP/GTP-binding site motif A (P-loop). 216595012669 PS00674 AAA-protein family signature. 216595012670 4 probable transmembrane helices predicted for PFLU2677 by TMHMM2.0 at aa 25-47, 60-82, 92-111 and 131-153 216595012671 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 216595012672 TPR motif; other site 216595012673 binding surface 216595012674 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 216595012675 binding surface 216595012676 TPR motif; other site 216595012679 2 probable transmembrane helices predicted for PFLU2678 by TMHMM2.0 at aa 252-271 and 284-303 216595012680 Protein of unknown function (DUF1315); Region: DUF1315; cl01215 216595012682 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 216595012683 aminopeptidase N; Provisional; Region: pepN; PRK14015 216595012684 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 216595012685 active site 216595012686 Zn binding site [ion binding]; other site 216595012688 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 216595012689 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595012690 Predicted transcriptional regulator [Transcription]; Region: COG2378 216595012692 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 216595012693 Predicted ATPase [General function prediction only]; Region: COG1485 216595012694 ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The...; Region: ABC_ATPase; cd00267 216595012695 Walker A/P-loop; other site 216595012696 ATP binding site [chemical binding]; other site 216595012697 Q-loop/lid; other site 216595012698 ABC transporter signature motif; other site 216595012699 Walker B; other site 216595012700 D-loop; other site 216595012701 H-loop/switch region; other site 216595012703 PS00017 ATP/GTP-binding site motif A (P-loop). 216595012704 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216595012705 Coenzyme A binding pocket [chemical binding]; other site 216595012707 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 216595012708 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216595012709 N-terminal plug; other site 216595012710 ligand-binding site [chemical binding]; other site 216595012713 hypothetical protein; Provisional; Region: PRK10649 216595012714 Sulfatase; Region: Sulfatase; cl10460 216595012716 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595012717 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 216595012721 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 216595012722 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 216595012723 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 216595012725 PS00069 Glucose-6-phosphate dehydrogenase active site. 216595012727 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 216595012728 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 216595012729 active site 216595012730 motif I; other site 216595012731 motif II; other site 216595012732 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 216595012734 PS01229 Hypothetical cof family signature 2. 216595012735 Protein of unknown function (DUF1652); Region: DUF1652; pfam07865 216595012736 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 216595012737 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595012738 Walker A motif; other site 216595012739 ATP binding site [chemical binding]; other site 216595012740 Walker B motif; other site 216595012741 arginine finger; other site 216595012742 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 216595012743 PS00190 Cytochrome c family heme-binding site signature. 216595012745 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 216595012746 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 216595012747 PS00688 Sigma-54 interaction domain C-terminal part signature. 216595012749 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 216595012750 putative active site [active] 216595012752 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595012753 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595012754 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 216595012755 FecR protein; Region: FecR; pfam04773 216595012757 1 probable transmembrane helix predicted for PFLU2702 by TMHMM2.0 at aa 94-116 216595012758 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 216595012759 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 216595012761 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 216595012763 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595012764 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595012765 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 216595012766 putative substrate binding pocket [chemical binding]; other site 216595012767 putative dimerization interface [polypeptide binding]; other site 216595012770 PS00044 Bacterial regulatory proteins, lysR family signature. 216595012771 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 216595012772 Predicted amidohydrolase [General function prediction only]; Region: COG0388 216595012773 putative active site [active] 216595012774 catalytic triad [active] 216595012775 putative dimer interface [polypeptide binding]; other site 216595012777 PS00921 Nitrilases / cyanide hydratase active site signature. 216595012778 Late embryogenesis abundant protein; Region: LEA_2; cl12118 216595012779 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595012780 Permease family; Region: Xan_ur_permease; pfam00860 216595012781 Sulfate transporter family; Region: Sulfate_transp; cl00967 216595012783 PS01116 Xanthine/uracil permeases family signature. 216595012784 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 216595012785 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595012786 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595012787 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595012788 2 probable transmembrane helices predicted for PFLU2711 by TMHMM2.0 at aa 30-52 and 210-232 216595012791 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 216595012792 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595012795 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 216595012796 PS00017 ATP/GTP-binding site motif A (P-loop). 216595012797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595012798 D-galactonate transporter; Region: 2A0114; TIGR00893 216595012799 putative substrate translocation pore; other site 216595012801 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595012802 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 216595012803 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 216595012804 substrate binding site [chemical binding]; other site 216595012805 ATP binding site [chemical binding]; other site 216595012807 PS00584 pfkB family of carbohydrate kinases signature 2. 216595012808 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 216595012810 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216595012811 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216595012812 DNA binding site [nucleotide binding] 216595012813 domain linker motif; other site 216595012814 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 216595012815 putative dimerization interface [polypeptide binding]; other site 216595012816 putative ligand binding site [chemical binding]; other site 216595012819 PS00356 Bacterial regulatory proteins, lacI family signature. 216595012820 LysE type translocator; Region: LysE; cl00565 216595012822 Cupin domain; Region: Cupin_2; cl09118 216595012823 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595012824 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216595012825 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595012828 Protein of unknown function (DUF1345); Region: DUF1345; cl01753 216595012830 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 216595012831 Protein export membrane protein; Region: SecD_SecF; cl14618 216595012833 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 216595012835 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595012836 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216595012837 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595012838 active site 216595012839 phosphorylation site [posttranslational modification] 216595012840 intermolecular recognition site; other site 216595012841 dimerization interface [polypeptide binding]; other site 216595012842 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 216595012843 DNA binding site [nucleotide binding] 216595012846 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595012847 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595012848 dimer interface [polypeptide binding]; other site 216595012849 phosphorylation site [posttranslational modification] 216595012850 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595012851 ATP binding site [chemical binding]; other site 216595012852 Mg2+ binding site [ion binding]; other site 216595012853 G-X-G motif; other site 216595012854 2 probable transmembrane helices predicted for PFLU2723 by TMHMM2.0 at aa 5-27 and 136-158 216595012858 Anti-sigma-K factor rskA; Region: RskA; cl02208 216595012859 1 probable transmembrane helix predicted for PFLU2724 by TMHMM2.0 at aa 81-103 216595012860 RNA polymerase sigma factor; Provisional; Region: PRK12537 216595012861 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216595012862 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 216595012863 DNA binding residues [nucleotide binding] 216595012866 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937 216595012867 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 216595012868 S-adenosylmethionine binding site [chemical binding]; other site 216595012870 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 216595012871 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 216595012872 6 probable transmembrane helices predicted for PFLU2728 by TMHMM2.0 at aa 4-26, 33-55, 75-97, 109-131, 146-180 and 215-237 216595012874 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 216595012875 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 216595012876 Flavin binding site [chemical binding]; other site 216595012879 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 216595012880 active site 216595012881 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 216595012882 dimer interface [polypeptide binding]; other site 216595012883 non-prolyl cis peptide bond; other site 216595012884 insertion regions; other site 216595012886 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 216595012887 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 216595012889 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 216595012890 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 216595012892 methionine aminopeptidase; Reviewed; Region: PRK07281 216595012893 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 216595012894 active site 216595012896 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 216595012898 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 216595012899 low G+C content region (40.79%) 216595012900 Protein of unknown function (DUF1652); Region: DUF1652; pfam07865 216595012902 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 216595012904 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 216595012905 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 216595012906 putative substrate binding site [chemical binding]; other site 216595012907 putative ATP binding site [chemical binding]; other site 216595012909 PS00584 pfkB family of carbohydrate kinases signature 2. 216595012910 D-xylulose kinases, subgroup 1; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809 216595012911 N- and C-terminal domain interface [polypeptide binding]; other site 216595012912 D-xylulose kinase; Region: XylB; TIGR01312 216595012913 active site 216595012914 catalytic site [active] 216595012915 metal binding site [ion binding]; metal-binding site 216595012916 xylulose binding site [chemical binding]; other site 216595012917 ATP binding site [chemical binding]; other site 216595012918 putative homodimer interface [polypeptide binding]; other site 216595012920 PS00445 FGGY family of carbohydrate kinases signature 2. 216595012922 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 216595012923 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 216595012924 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 216595012926 PS00974 Mannitol dehydrogenases signature. 216595012928 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216595012929 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 216595012930 Walker A/P-loop; other site 216595012931 ATP binding site [chemical binding]; other site 216595012932 Q-loop/lid; other site 216595012933 ABC transporter signature motif; other site 216595012934 Walker B; other site 216595012935 D-loop; other site 216595012936 H-loop/switch region; other site 216595012937 TOBE domain; Region: TOBE_2; cl01440 216595012938 TOBE domain; Region: TOBE_2; cl01440 216595012941 PS00211 ABC transporters family signature. 216595012942 PS00017 ATP/GTP-binding site motif A (P-loop). 216595012943 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216595012944 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595012945 dimer interface [polypeptide binding]; other site 216595012946 conserved gate region; other site 216595012947 putative PBP binding loops; other site 216595012948 ABC-ATPase subunit interface; other site 216595012950 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595012951 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 216595012952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595012953 dimer interface [polypeptide binding]; other site 216595012954 conserved gate region; other site 216595012955 putative PBP binding loops; other site 216595012956 ABC-ATPase subunit interface; other site 216595012958 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595012959 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216595012960 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595012962 1 probable transmembrane helix predicted for PFLU2745 by TMHMM2.0 at aa 12-34 216595012963 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595012964 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216595012965 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595012967 PS00041 Bacterial regulatory proteins, araC family signature. 216595012969 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216595012970 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 216595012971 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595012972 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 216595012973 dimer interface [polypeptide binding]; other site 216595012974 catalytic triad [active] 216595012975 peroxidatic and resolving cysteines [active] 216595012977 PS01265 Tpx family signature. 216595012978 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 216595012979 1 probable transmembrane helix predicted for PFLU2749 by TMHMM2.0 at aa 13-35 216595012981 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 216595012982 Protein export membrane protein; Region: SecD_SecF; cl14618 216595012984 10 probable transmembrane helices predicted for PFLU2750 by TMHMM2.0 at aa 7-29, 334-353, 360-382, 430-452, 459-481, 527-549, 859-881, 901-923, 954-976 and 991-1013 216595012985 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 216595012986 Protein export membrane protein; Region: SecD_SecF; cl14618 216595012988 10 probable transmembrane helices predicted for PFLU2751 by TMHMM2.0 at aa 12-34, 336-353, 360-382, 434-456, 463-485, 529-548, 857-879, 899-921, 952-974 and 989-1011 216595012989 NodT family; Region: outer_NodT; TIGR01845 216595012990 Outer membrane efflux protein; Region: OEP; pfam02321 216595012991 Outer membrane efflux protein; Region: OEP; pfam02321 216595012993 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595012996 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 216595012997 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 216595012998 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216595012999 metal binding site [ion binding]; metal-binding site 216595013000 active site 216595013001 I-site; other site 216595013002 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216595013003 7 probable transmembrane helices predicted for PFLU2753 by TMHMM2.0 at aa 20-42, 55-77, 92-113, 120-142, 157-179, 192-214 and 234-253 216595013009 short chain dehydrogenase; Provisional; Region: PRK06123 216595013010 classical (c) SDRs; Region: SDR_c; cd05233 216595013011 NAD(P) binding site [chemical binding]; other site 216595013012 active site 216595013014 PS00061 Short-chain dehydrogenases/reductases family signature. 216595013015 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 216595013016 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595013017 DNA-binding site [nucleotide binding]; DNA binding site 216595013018 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216595013019 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595013020 homodimer interface [polypeptide binding]; other site 216595013021 catalytic residue [active] 216595013024 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 216595013025 4Fe-4S binding domain; Region: Fer4_5; pfam12801 216595013026 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 216595013027 PS00017 ATP/GTP-binding site motif A (P-loop). 216595013029 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216595013030 Protein of unknown function (DUF3203); Region: DUF3203; pfam11462 216595013031 MgtC family; Region: MgtC; cl12207 216595013032 5 probable transmembrane helices predicted for PFLU2759 by TMHMM2.0 at aa 28-45, 52-74, 84-102, 114-133 and 138-157 216595013034 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 216595013035 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 216595013037 PS00019 Actinin-type actin-binding domain signature 1. 216595013038 trehalose synthase; Region: treS_nterm; TIGR02456 216595013039 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 216595013040 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 216595013042 PS00697 ATP-dependent DNA ligase AMP-binding site. 216595013044 glycogen branching enzyme; Provisional; Region: PRK05402 216595013045 Glycogen branching enzyme N-terminus domain. Glycogen branching enzyme (AKA 1,4 alpha glucan branching enzyme) catalyzes the formation of alpha-1,6 branch points in either glycogen or starch by cleavage of the alpha-1,4 glucosidic linkage yielding a...; Region: Glycogen_branching_enzyme_N_term; cd02855 216595013046 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 216595013047 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 216595013051 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216595013052 metal binding site [ion binding]; metal-binding site 216595013053 active site 216595013054 I-site; other site 216595013055 5 probable transmembrane helices predicted for PFLU2764 by TMHMM2.0 at aa 43-65, 69-88, 108-127, 155-177 and 184-201 216595013057 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 216595013058 GAF domain; Region: GAF; cl00853 216595013059 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595013060 dimer interface [polypeptide binding]; other site 216595013061 phosphorylation site [posttranslational modification] 216595013062 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595013063 ATP binding site [chemical binding]; other site 216595013064 Mg2+ binding site [ion binding]; other site 216595013065 G-X-G motif; other site 216595013066 Response regulator receiver domain; Region: Response_reg; pfam00072 216595013067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595013068 active site 216595013069 phosphorylation site [posttranslational modification] 216595013070 intermolecular recognition site; other site 216595013071 dimerization interface [polypeptide binding]; other site 216595013076 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 216595013077 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 216595013079 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 216595013081 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595013082 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595013083 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 216595013084 putative substrate binding pocket [chemical binding]; other site 216595013085 putative dimerization interface [polypeptide binding]; other site 216595013087 PS00044 Bacterial regulatory proteins, lysR family signature. 216595013089 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 216595013091 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216595013092 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216595013094 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 216595013096 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 216595013097 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556 216595013098 hinge; other site 216595013099 active site 216595013101 PS00104 EPSP synthase signature 1. 216595013102 Uncharacterised protein family (UPF0149); Region: UPF0149; cl01173 216595013103 1 probable transmembrane helix predicted for PFLU2776 by TMHMM2.0 at aa 7-29 216595013104 enoyl-CoA hydratase; Provisional; Region: PRK06142 216595013105 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 216595013106 substrate binding site [chemical binding]; other site 216595013107 oxyanion hole (OAH) forming residues; other site 216595013108 trimer interface [polypeptide binding]; other site 216595013110 PS00166 Enoyl-CoA hydratase/isomerase signature. 216595013111 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 216595013112 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 216595013113 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 216595013114 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 216595013115 putative NADH binding site [chemical binding]; other site 216595013116 putative active site [active] 216595013117 nudix motif; other site 216595013118 putative metal binding site [ion binding]; other site 216595013122 PS00893 mutT domain signature. 216595013123 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 216595013125 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 216595013126 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 216595013128 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 216595013129 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 216595013131 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 216595013132 dimer interface [polypeptide binding]; other site 216595013133 putative radical transfer pathway; other site 216595013134 diiron center [ion binding]; other site 216595013135 tyrosyl radical; other site 216595013137 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 216595013138 YheO-like PAS domain; Region: PAS_6; pfam08348 216595013140 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 216595013141 homotrimer interaction site [polypeptide binding]; other site 216595013142 putative active site [active] 216595013144 serine/threonine dehydratase; Validated; Region: PRK07048 216595013145 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 216595013146 tetramer interface [polypeptide binding]; other site 216595013147 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595013148 catalytic residue [active] 216595013150 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 216595013151 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 216595013152 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 216595013155 fec operon regulator FecR; Reviewed; Region: PRK09774 216595013156 FecR protein; Region: FecR; pfam04773 216595013158 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 216595013159 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 216595013160 Walker A/P-loop; other site 216595013161 ATP binding site [chemical binding]; other site 216595013162 Q-loop/lid; other site 216595013163 ABC transporter signature motif; other site 216595013164 Walker B; other site 216595013165 D-loop; other site 216595013166 H-loop/switch region; other site 216595013168 PS00211 ABC transporters family signature. 216595013169 PS00017 ATP/GTP-binding site motif A (P-loop). 216595013170 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595013171 dimer interface [polypeptide binding]; other site 216595013172 conserved gate region; other site 216595013173 putative PBP binding loops; other site 216595013174 ABC-ATPase subunit interface; other site 216595013176 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595013177 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 216595013178 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595013179 substrate binding pocket [chemical binding]; other site 216595013180 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 216595013181 membrane-bound complex binding site; other site 216595013183 low G+C content region (36.5%) 216595013184 TOBE domain; Region: TOBE_2; cl01440 216595013186 aspartate aminotransferase; Provisional; Region: PRK08361 216595013187 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216595013188 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595013189 homodimer interface [polypeptide binding]; other site 216595013190 catalytic residue [active] 216595013192 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 216595013193 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595013194 putative substrate translocation pore; other site 216595013196 Isochorismatase family; Region: Isochorismatase; pfam00857 216595013197 N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This CSHase-...; Region: CSHase; cd01015 216595013198 substrate binding site [chemical binding]; other site 216595013199 catalytic triad [active] 216595013200 domain interfaces; other site 216595013201 conserved cis-peptide bond; other site 216595013203 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 216595013205 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216595013207 hypothetical protein; Provisional; Region: PRK06847 216595013208 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595013210 low G+C content region (36.8%) 216595013211 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 216595013212 Transcriptional regulators [Transcription]; Region: MarR; COG1846 216595013213 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595013215 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 216595013216 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 216595013218 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 216595013220 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 216595013221 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 216595013222 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 216595013223 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 216595013224 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 216595013225 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 216595013226 Cytochrome c; Region: Cytochrom_C; cl11414 216595013229 PS00030 Eukaryotic putative RNA-binding region RNP-1 signature. 216595013231 PS00190 Cytochrome c family heme-binding site signature. 216595013232 PS00190 Cytochrome c family heme-binding site signature. 216595013234 PS00190 Cytochrome c family heme-binding site signature. 216595013235 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216595013236 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216595013238 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 216595013239 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 216595013241 PS00462 Gamma-glutamyltranspeptidase signature. 216595013242 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; cl01238 216595013243 PS00017 ATP/GTP-binding site motif A (P-loop). 216595013244 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 216595013246 Cache domain; Region: Cache_2; cl07034 216595013247 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595013248 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595013249 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595013253 Bacitracin resistance protein BacA; Region: BacA; cl00858 216595013255 6 probable transmembrane helices predicted for PFLU2809 by TMHMM2.0 at aa 44-63, 83-105, 109-128, 187-205, 220-242 and 249-268 216595013256 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 216595013257 3 probable transmembrane helices predicted for PFLU2810 by TMHMM2.0 at aa 12-29, 33-52 and 96-113 216595013259 Protein of unknown function (DUF419); Region: DUF419; cl15265 216595013261 LysR family transcriptional regulator; Provisional; Region: PRK14997 216595013262 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595013263 dimerization interface [polypeptide binding]; other site 216595013266 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 216595013268 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 216595013269 PS00120 Lipases, serine active site. 216595013270 major facilitator superfamily transporter; Provisional; Region: PRK05122 216595013271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595013272 putative substrate translocation pore; other site 216595013274 PS00012 Phosphopantetheine attachment site. 216595013276 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 216595013277 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595013278 Walker A/P-loop; other site 216595013279 ATP binding site [chemical binding]; other site 216595013280 Q-loop/lid; other site 216595013281 ABC transporter signature motif; other site 216595013282 Walker B; other site 216595013283 D-loop; other site 216595013284 H-loop/switch region; other site 216595013285 ABC transporter; Region: ABC_tran_2; pfam12848 216595013286 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 216595013288 PS00017 ATP/GTP-binding site motif A (P-loop). 216595013290 PS00017 ATP/GTP-binding site motif A (P-loop). 216595013291 Prophage 3 216595013292 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 216595013293 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 216595013294 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 216595013295 DNA binding site [nucleotide binding] 216595013296 Int/Topo IB signature motif; other site 216595013297 active site 216595013299 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 216595013301 3 probable transmembrane helices predicted for PFLU2828 by TMHMM2.0 at aa 20-37, 52-71 and 99-121 216595013302 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 216595013303 cofactor binding site; other site 216595013304 DNA binding site [nucleotide binding] 216595013305 substrate interaction site [chemical binding]; other site 216595013307 4 probable transmembrane helices predicted for PFLU2830 by TMHMM2.0 at aa 20-42, 108-130, 140-159 and 207-226 216595013308 Phage-related protein, predicted endonuclease [DNA replication, recombination, and repair]; Region: COG5377 216595013309 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 216595013310 ribonuclease E; Reviewed; Region: rne; PRK10811 216595013311 RecT family; Region: RecT; cl04285 216595013313 PS00017 ATP/GTP-binding site motif A (P-loop). 216595013314 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216595013315 Protein of unknown function (DUF1654); Region: DUF1654; pfam07867 216595013317 3 probable transmembrane helices predicted for PFLU2844 by TMHMM2.0 at aa 79-101, 116-138 and 159-181 216595013318 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 216595013319 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 216595013320 Domain of unknown function (DUF955); Region: DUF955; cl01076 216595013322 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 216595013324 1 probable transmembrane helix predicted for PFLU2847 by TMHMM2.0 at aa 27-44 216595013325 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 216595013326 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216595013327 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 216595013328 non-specific DNA binding site [nucleotide binding]; other site 216595013329 salt bridge; other site 216595013330 sequence-specific DNA binding site [nucleotide binding]; other site 216595013331 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 216595013332 Catalytic site [active] 216595013335 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216595013336 non-specific DNA binding site [nucleotide binding]; other site 216595013337 salt bridge; other site 216595013338 sequence-specific DNA binding site [nucleotide binding]; other site 216595013340 NAD-dependent deacetylase; Provisional; Region: PRK14138 216595013341 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 216595013343 5 probable transmembrane helices predicted for PFLU2857 by TMHMM2.0 at aa 42-64, 93-115, 122-139, 144-161 and 191-213 216595013344 Mu-like prophage protein Com; Region: Mu-like_Com; cl11540 216595013345 1 probable transmembrane helix predicted for PFLU2860 by TMHMM2.0 at aa 10-32 216595013346 1 probable transmembrane helix predicted for PFLU2861 by TMHMM2.0 at aa 20-42 216595013347 large terminase protein; Provisional; Region: 17; PHA02533 216595013348 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 216595013349 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 216595013350 HeH/LEM domain; Region: HeH; pfam12949 216595013351 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 216595013352 Phage tail protein; Region: Phage_tail_3; pfam08813 216595013354 Domain of unknown function (DUF1789); Region: DUF1789; pfam08748 216595013356 Phage related hypothetical protein (DUF1799); Region: DUF1799; pfam08809 216595013358 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 216595013359 phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541 216595013360 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 216595013362 Phage minor tail protein; Region: Phage_min_tail; cl01940 216595013364 Phage minor tail protein L; Region: Phage_tail_L; cl01908 216595013366 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 216595013367 MPN+ (JAMM) motif; other site 216595013368 Zinc-binding site [ion binding]; other site 216595013369 NlpC/P60 family; Region: NLPC_P60; cl11438 216595013371 Uncharacterized conserved protein [Function unknown]; Region: COG4748 216595013372 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 216595013374 1 probable transmembrane helix predicted for PFLU2890 by TMHMM2.0 at aa 20-39 216595013375 Bacteriophage lambda tail assembly protein I; Region: Lambda_tail_I; cl01945 216595013377 1 probable transmembrane helix predicted for PFLU2891 by TMHMM2.0 at aa 103-125 216595013378 Phage-related protein, tail component [Function unknown]; Region: COG4733 216595013379 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 216595013382 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 216595013384 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 216595013385 1 probable transmembrane helix predicted for PFLU2897 by TMHMM2.0 at aa 7-26 216595013386 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 216595013388 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 216595013389 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 216595013390 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase; Provisional; Region: PTZ00322 216595013396 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216595013397 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595013399 PS00216 Sugar transport proteins signature 1. 216595013400 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 216595013401 S-adenosylmethionine binding site [chemical binding]; other site 216595013403 Planctomycetes uncharacterized domain TIGR03067; Region: Planc_TIGR03067 216595013404 Chain length determinant protein; Region: Wzz; cl01623 216595013405 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 216595013407 2 probable transmembrane helices predicted for PFLU2909 by TMHMM2.0 at aa 31-50 and 395-414 216595013408 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl01426 216595013410 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 216595013411 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 216595013412 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 216595013413 active site 216595013414 DNA binding site [nucleotide binding] 216595013415 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 216595013416 DNA binding site [nucleotide binding] 216595013417 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for non-...; Region: PaeLigD_Pol_like; cd04862 216595013418 nucleotide binding site [chemical binding]; other site 216595013422 PS00697 ATP-dependent DNA ligase AMP-binding site. 216595013423 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 216595013424 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 216595013425 putative DNA binding site [nucleotide binding]; other site 216595013426 putative homodimer interface [polypeptide binding]; other site 216595013428 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 216595013429 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 216595013431 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 216595013433 putative transcriptional regulator; Provisional; Region: PRK11640 216595013434 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216595013436 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 216595013437 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 216595013438 domain interface [polypeptide binding]; other site 216595013439 putative active site [active] 216595013440 catalytic site [active] 216595013441 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 216595013442 domain interface [polypeptide binding]; other site 216595013443 putative active site [active] 216595013444 catalytic site [active] 216595013447 Imelysin; Region: Peptidase_M75; cl09159 216595013449 1 probable transmembrane helix predicted for PFLU2918 by TMHMM2.0 at aa 7-29 216595013450 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 216595013451 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 216595013453 1 probable transmembrane helix predicted for PFLU2919 by TMHMM2.0 at aa 21-43 216595013454 Imelysin; Region: Peptidase_M75; cl09159 216595013456 1 probable transmembrane helix predicted for PFLU2920 by TMHMM2.0 at aa 15-37 216595013457 Iron permease FTR1 family; Region: FTR1; cl00475 216595013459 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cl02542 216595013461 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 216595013462 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216595013464 low G+C content region (39.42%) 216595013465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595013466 putative substrate translocation pore; other site 216595013467 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216595013469 PS00216 Sugar transport proteins signature 1. 216595013470 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595013471 ATP binding site [chemical binding]; other site 216595013472 substrate interface [chemical binding]; other site 216595013474 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595013475 Walker A/P-loop; other site 216595013476 ATP binding site [chemical binding]; other site 216595013477 Q-loop/lid; other site 216595013478 ABC transporter signature motif; other site 216595013479 Walker B; other site 216595013480 D-loop; other site 216595013481 H-loop/switch region; other site 216595013483 PS00017 ATP/GTP-binding site motif A (P-loop). 216595013484 JmjC domain; Region: JmjC; pfam02373 216595013486 NodT family; Region: outer_NodT; TIGR01845 216595013487 Outer membrane efflux protein; Region: OEP; pfam02321 216595013488 Outer membrane efflux protein; Region: OEP; pfam02321 216595013491 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595013492 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 216595013494 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 216595013496 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595013497 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 216595013499 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595013500 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595013501 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 216595013502 putative substrate binding pocket [chemical binding]; other site 216595013503 dimerization interface [polypeptide binding]; other site 216595013506 PS00044 Bacterial regulatory proteins, lysR family signature. 216595013507 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 216595013509 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 216595013510 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 216595013511 1 probable transmembrane helix predicted for PFLU2935 by TMHMM2.0 at aa 7-29 216595013513 Response regulator receiver domain; Region: Response_reg; pfam00072 216595013514 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595013515 active site 216595013516 phosphorylation site [posttranslational modification] 216595013517 intermolecular recognition site; other site 216595013518 dimerization interface [polypeptide binding]; other site 216595013520 CHASE3 domain; Region: CHASE3; cl05000 216595013521 PAS fold; Region: PAS; pfam00989 216595013522 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216595013523 putative active site [active] 216595013524 heme pocket [chemical binding]; other site 216595013525 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595013526 dimer interface [polypeptide binding]; other site 216595013527 phosphorylation site [posttranslational modification] 216595013528 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595013529 ATP binding site [chemical binding]; other site 216595013530 Mg2+ binding site [ion binding]; other site 216595013531 G-X-G motif; other site 216595013532 Response regulator receiver domain; Region: Response_reg; pfam00072 216595013533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595013534 active site 216595013535 phosphorylation site [posttranslational modification] 216595013536 intermolecular recognition site; other site 216595013537 dimerization interface [polypeptide binding]; other site 216595013544 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216595013545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595013546 active site 216595013547 phosphorylation site [posttranslational modification] 216595013548 intermolecular recognition site; other site 216595013549 dimerization interface [polypeptide binding]; other site 216595013550 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 216595013551 DNA binding residues [nucleotide binding] 216595013552 dimerization interface [polypeptide binding]; other site 216595013555 Histidine kinase; Region: HisKA_3; pfam07730 216595013556 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595013557 ATP binding site [chemical binding]; other site 216595013558 Mg2+ binding site [ion binding]; other site 216595013559 G-X-G motif; other site 216595013563 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 216595013565 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 216595013566 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216595013567 N-terminal plug; other site 216595013568 ligand-binding site [chemical binding]; other site 216595013571 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 216595013572 1 probable transmembrane helix predicted for PFLU2942 by TMHMM2.0 at aa 7-29 216595013573 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 216595013574 putative ligand binding site [chemical binding]; other site 216595013575 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 216595013576 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 216595013577 Walker A/P-loop; other site 216595013578 ATP binding site [chemical binding]; other site 216595013579 Q-loop/lid; other site 216595013580 ABC transporter signature motif; other site 216595013581 Walker B; other site 216595013582 D-loop; other site 216595013583 H-loop/switch region; other site 216595013584 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216595013585 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 216595013586 Walker A/P-loop; other site 216595013587 ATP binding site [chemical binding]; other site 216595013588 Q-loop/lid; other site 216595013589 ABC transporter signature motif; other site 216595013590 Walker B; other site 216595013591 D-loop; other site 216595013592 H-loop/switch region; other site 216595013595 PS00211 ABC transporters family signature. 216595013596 PS00017 ATP/GTP-binding site motif A (P-loop). 216595013599 PS00211 ABC transporters family signature. 216595013600 PS00017 ATP/GTP-binding site motif A (P-loop). 216595013601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 216595013602 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595013603 dimer interface [polypeptide binding]; other site 216595013604 ABC-ATPase subunit interface; other site 216595013605 putative PBP binding loops; other site 216595013607 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595013608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595013609 dimer interface [polypeptide binding]; other site 216595013610 conserved gate region; other site 216595013611 putative PBP binding loops; other site 216595013612 ABC-ATPase subunit interface; other site 216595013614 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 216595013615 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 216595013617 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 216595013618 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216595013619 N-terminal plug; other site 216595013620 ligand-binding site [chemical binding]; other site 216595013622 PS00092 N-6 Adenine-specific DNA methylases signature. 216595013624 very low G+C content region (26.89%) 216595013625 Protein of unknown function (DUF2388); Region: DUF2388; cl09731 216595013626 Protein of unknown function (DUF2388); Region: DUF2388; cl09731 216595013627 1 probable transmembrane helix predicted for PFLU2950 by TMHMM2.0 at aa 28-50 216595013628 DinB superfamily; Region: DinB_2; cl00986 216595013630 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 216595013631 putative metal binding site [ion binding]; other site 216595013633 1 probable transmembrane helix predicted for PFLU2955 by TMHMM2.0 at aa 43-60 216595013634 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 216595013635 magnesium-transporting ATPase; Provisional; Region: PRK15122 216595013636 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 216595013637 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216595013638 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 216595013639 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 216595013641 PS00154 E1-E2 ATPases phosphorylation site. 216595013644 low G+C content region (46.28%) 216595013645 low G+C content region (41.48%) 216595013646 LysE type translocator; Region: LysE; cl00565 216595013648 Cupin domain; Region: Cupin_2; cl09118 216595013649 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595013650 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216595013651 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595013655 Low molecular weight phosphatase family; Region: LMWPc; cd00115 216595013656 Active site [active] 216595013658 arsenical pump membrane protein; Provisional; Region: PRK15445 216595013659 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 216595013660 transmembrane helices; other site 216595013662 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595013663 AzlC protein; Region: AzlC; cl00570 216595013664 5 probable transmembrane helices predicted for PFLU2963 by TMHMM2.0 at aa 13-35, 50-72, 131-153, 163-180 and 187-209 216595013666 PS00017 ATP/GTP-binding site motif A (P-loop). 216595013667 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 216595013668 4 probable transmembrane helices predicted for PFLU2964 by TMHMM2.0 at aa 2-21, 36-55, 62-81 and 85-102 216595013670 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 216595013672 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 216595013673 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595013674 Walker A/P-loop; other site 216595013675 ATP binding site [chemical binding]; other site 216595013676 Q-loop/lid; other site 216595013677 ABC transporter signature motif; other site 216595013678 Walker B; other site 216595013679 D-loop; other site 216595013680 H-loop/switch region; other site 216595013681 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 216595013682 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 216595013683 G1 box; other site 216595013684 GTP/Mg2+ binding site [chemical binding]; other site 216595013686 PS00017 ATP/GTP-binding site motif A (P-loop). 216595013688 PS00211 ABC transporters family signature. 216595013689 PS00017 ATP/GTP-binding site motif A (P-loop). 216595013690 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes...; Region: Topo_IB_C; cd00659 216595013691 DNA binding site [nucleotide binding] 216595013692 active site 216595013693 Int/Topo IB signature motif; other site 216595013694 catalytic residues [active] 216595013696 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595013697 molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142 216595013698 Walker A/P-loop; other site 216595013699 ATP binding site [chemical binding]; other site 216595013700 Q-loop/lid; other site 216595013701 ABC transporter signature motif; other site 216595013702 Walker B; other site 216595013703 D-loop; other site 216595013704 H-loop/switch region; other site 216595013705 TOBE domain; Region: TOBE_2; cl01440 216595013708 PS00211 ABC transporters family signature. 216595013709 PS00017 ATP/GTP-binding site motif A (P-loop). 216595013710 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595013711 dimer interface [polypeptide binding]; other site 216595013712 conserved gate region; other site 216595013713 putative PBP binding loops; other site 216595013714 ABC-ATPase subunit interface; other site 216595013716 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595013718 Nitronate monooxygenase; Region: NMO; pfam03060 216595013719 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 216595013720 FMN binding site [chemical binding]; other site 216595013721 substrate binding site [chemical binding]; other site 216595013722 putative catalytic residue [active] 216595013724 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216595013726 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 216595013727 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 216595013728 CGNR zinc finger; Region: zf-CGNR; pfam11706 216595013730 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 216595013731 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 216595013732 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 216595013733 DNA binding site [nucleotide binding] 216595013734 active site 216595013736 PS00374 Methylated-DNA--protein-cysteine methyltransferase active site. 216595013739 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 216595013741 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 216595013743 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595013744 Cytochrome c; Region: Cytochrom_C; cl11414 216595013745 Cytochrome c; Region: Cytochrom_C; cl11414 216595013746 PS00190 Cytochrome c family heme-binding site signature. 216595013748 PS00190 Cytochrome c family heme-binding site signature. 216595013749 Cytochrome c [Energy production and conversion]; Region: COG3258 216595013750 Cytochrome c; Region: Cytochrom_C; cl11414 216595013751 PS00190 Cytochrome c family heme-binding site signature. 216595013753 PS00190 Cytochrome c family heme-binding site signature. 216595013754 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595013755 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 216595013756 active site 216595013757 tetramer interface [polypeptide binding]; other site 216595013759 glutathione reductase; Validated; Region: PRK06116 216595013760 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595013761 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 216595013763 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 216595013766 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 216595013767 low G+C content region (39.59%) 216595013768 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 216595013769 DNA binding site [nucleotide binding] 216595013770 dimer interface [polypeptide binding]; other site 216595013771 Int/Topo IB signature motif; other site 216595013772 active site 216595013774 peroxiredoxin; Region: AhpC; TIGR03137 216595013775 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic...; Region: PRX_Typ2cys; cd03015 216595013776 dimer interface [polypeptide binding]; other site 216595013777 decamer (pentamer of dimers) interface [polypeptide binding]; other site 216595013778 catalytic triad [active] 216595013779 peroxidatic and resolving cysteines [active] 216595013781 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 216595013782 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the...; Region: AhpF_NTD_N; cd02974 216595013783 catalytic residue [active] 216595013784 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 216595013785 catalytic residues [active] 216595013786 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595013788 PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. 216595013790 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 216595013791 dimer interface [polypeptide binding]; other site 216595013792 active site 216595013793 metal binding site [ion binding]; metal-binding site 216595013794 glutathione binding site [chemical binding]; other site 216595013796 PS00935 Glyoxalase I signature 2. 216595013797 PS00934 Glyoxalase I signature 1. 216595013798 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 216595013799 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 216595013800 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216595013802 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595013803 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595013804 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 216595013805 dimerization interface [polypeptide binding]; other site 216595013808 PS00044 Bacterial regulatory proteins, lysR family signature. 216595013809 EamA-like transporter family; Region: EamA; cl01037 216595013810 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 216595013811 EamA-like transporter family; Region: EamA; cl01037 216595013812 10 probable transmembrane helices predicted for PFLU2996 by TMHMM2.0 at aa 33-55, 65-87, 99-117, 122-144, 151-169, 179-201, 214-236, 246-268, 281-298 and 302-321 216595013815 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 216595013816 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 216595013817 dimer interface [polypeptide binding]; other site 216595013818 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 216595013819 active site 216595013820 Fe binding site [ion binding]; other site 216595013822 Predicted permeases [General function prediction only]; Region: RarD; COG2962 216595013823 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 216595013824 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 216595013825 active site 216595013826 catalytic tetrad [active] 216595013828 transcriptional activator TtdR; Provisional; Region: PRK09801 216595013829 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595013830 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 216595013831 putative effector binding pocket; other site 216595013832 dimerization interface [polypeptide binding]; other site 216595013835 PS00044 Bacterial regulatory proteins, lysR family signature. 216595013836 classical (c) SDRs; Region: SDR_c; cd05233 216595013837 NAD(P) binding site [chemical binding]; other site 216595013838 active site 216595013840 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 216595013841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595013842 putative substrate translocation pore; other site 216595013844 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 216595013845 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 216595013848 Glycerate kinase family; Region: Gly_kinase; cl00841 216595013850 PS00017 ATP/GTP-binding site motif A (P-loop). 216595013851 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 216595013852 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 216595013855 Protein involved in meta-pathway of phenol degradation [Energy production and conversion]; Region: COG4313 216595013856 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 216595013857 DNA binding residues [nucleotide binding] 216595013858 dimerization interface [polypeptide binding]; other site 216595013860 putative acetyltransferase YhhY; Provisional; Region: PRK10140 216595013861 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 216595013863 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 216595013864 aspartate racemase; Region: asp_race; TIGR00035 216595013866 PS00924 Aspartate and glutamate racemases signature 2. 216595013867 PS00923 Aspartate and glutamate racemases signature 1. 216595013868 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of...; Region: cbb3_Oxidase_CcoQ; cl00282 216595013869 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily...; Region: Heme_Cu_Oxidase_I; cl00275 216595013870 Low-spin heme binding site [chemical binding]; other site 216595013871 D-pathway; other site 216595013872 Putative water exit pathway; other site 216595013873 Binuclear center (active site) [active] 216595013874 K-pathway; other site 216595013875 Putative proton exit pathway; other site 216595013877 PS00077 Heme-copper oxidase catalytic subunit, copper B binding region signature. 216595013878 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 216595013879 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595013880 Uncharacterized conserved protein [Function unknown]; Region: COG5361 216595013881 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 216595013882 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 216595013885 Response regulator receiver domain; Region: Response_reg; pfam00072 216595013886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595013887 active site 216595013888 phosphorylation site [posttranslational modification] 216595013889 intermolecular recognition site; other site 216595013890 dimerization interface [polypeptide binding]; other site 216595013892 CHASE3 domain; Region: CHASE3; cl05000 216595013893 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 216595013894 GAF domain; Region: GAF; cl00853 216595013895 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 216595013896 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 216595013897 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595013898 ATP binding site [chemical binding]; other site 216595013899 Mg2+ binding site [ion binding]; other site 216595013900 G-X-G motif; other site 216595013901 Response regulator receiver domain; Region: Response_reg; pfam00072 216595013902 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595013903 active site 216595013904 phosphorylation site [posttranslational modification] 216595013905 intermolecular recognition site; other site 216595013906 dimerization interface [polypeptide binding]; other site 216595013907 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 216595013908 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595013909 active site 216595013910 phosphorylation site [posttranslational modification] 216595013911 intermolecular recognition site; other site 216595013912 dimerization interface [polypeptide binding]; other site 216595013913 Response regulator receiver domain; Region: Response_reg; pfam00072 216595013914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595013915 active site 216595013916 phosphorylation site [posttranslational modification] 216595013917 intermolecular recognition site; other site 216595013918 dimerization interface [polypeptide binding]; other site 216595013919 2 probable transmembrane helices predicted for PFLU3017 by TMHMM2.0 at aa 41-63 and 202-224 216595013921 PS00215 Mitochondrial energy transfer proteins signature. 216595013926 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 216595013929 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 216595013930 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 216595013931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 216595013934 CheB methylesterase; Region: CheB_methylest; pfam01339 216595013935 1 probable transmembrane helix predicted for PFLU3019 by TMHMM2.0 at aa 13-35 216595013937 ggaaccnnnnnnnnnnnnnnnnccacnna 216595013938 Response regulator receiver domain; Region: Response_reg; pfam00072 216595013939 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595013940 active site 216595013941 phosphorylation site [posttranslational modification] 216595013942 intermolecular recognition site; other site 216595013943 dimerization interface [polypeptide binding]; other site 216595013944 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595013945 dimer interface [polypeptide binding]; other site 216595013946 phosphorylation site [posttranslational modification] 216595013947 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595013948 ATP binding site [chemical binding]; other site 216595013949 Mg2+ binding site [ion binding]; other site 216595013950 G-X-G motif; other site 216595013954 Response regulator receiver domain; Region: Response_reg; pfam00072 216595013955 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595013956 active site 216595013957 phosphorylation site [posttranslational modification] 216595013958 intermolecular recognition site; other site 216595013959 dimerization interface [polypeptide binding]; other site 216595013961 Yersinia/Haemophilus virulence surface antigen; Region: Peptidase_C58; cl04145 216595013962 PS00136 Serine proteases, subtilase family, aspartic acid active site. 216595013963 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 216595013964 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595013965 dimer interface [polypeptide binding]; other site 216595013966 phosphorylation site [posttranslational modification] 216595013967 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595013968 ATP binding site [chemical binding]; other site 216595013969 Mg2+ binding site [ion binding]; other site 216595013970 G-X-G motif; other site 216595013971 Response regulator receiver domain; Region: Response_reg; pfam00072 216595013972 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595013973 active site 216595013974 phosphorylation site [posttranslational modification] 216595013975 intermolecular recognition site; other site 216595013976 dimerization interface [polypeptide binding]; other site 216595013980 circadian clock protein KaiC; Reviewed; Region: PRK09302 216595013981 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595013982 Walker A motif; other site 216595013983 ATP binding site [chemical binding]; other site 216595013984 Walker B motif; other site 216595013985 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595013986 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595013987 Walker A motif; other site 216595013988 Walker A motif; other site 216595013989 ATP binding site [chemical binding]; other site 216595013990 Walker B motif; other site 216595013992 PS00017 ATP/GTP-binding site motif A (P-loop). 216595013994 PS00017 ATP/GTP-binding site motif A (P-loop). 216595013995 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 216595013996 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 216595013997 TPR motif; other site 216595013998 binding surface 216595014002 1 probable transmembrane helix predicted for PFLU3025 by TMHMM2.0 at aa 7-26 216595014003 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 216595014005 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 216595014006 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595014007 NAD(P) binding site [chemical binding]; other site 216595014008 active site 216595014010 1 probable transmembrane helix predicted for PFLU3027 by TMHMM2.0 at aa 7-29 216595014011 PS00061 Short-chain dehydrogenases/reductases family signature. 216595014012 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 216595014013 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 216595014014 dimer interface [polypeptide binding]; other site 216595014015 active site 216595014018 PS00099 Thiolases active site. 216595014019 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216595014020 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216595014021 active site 216595014024 PS00072 Acyl-CoA dehydrogenases signature 1. 216595014026 PS00073 Acyl-CoA dehydrogenases signature 2. 216595014027 enoyl-CoA hydratase; Provisional; Region: PRK05862 216595014028 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 216595014029 substrate binding site [chemical binding]; other site 216595014030 oxyanion hole (OAH) forming residues; other site 216595014031 trimer interface [polypeptide binding]; other site 216595014033 PS00166 Enoyl-CoA hydratase/isomerase signature. 216595014034 PS00017 ATP/GTP-binding site motif A (P-loop). 216595014035 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216595014036 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216595014037 active site 216595014039 PS00073 Acyl-CoA dehydrogenases signature 2. 216595014042 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 216595014043 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 216595014044 substrate binding site [chemical binding]; other site 216595014045 oxyanion hole (OAH) forming residues; other site 216595014046 trimer interface [polypeptide binding]; other site 216595014048 HPP family; Region: HPP; pfam04982 216595014050 Protein of unknown function (DUF770); Region: DUF770; cl01402 216595014051 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 216595014053 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 216595014054 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595014055 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 216595014056 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595014060 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 216595014061 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 216595014063 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595014064 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 216595014065 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 216595014067 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 216595014068 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 216595014070 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 216595014071 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 216595014072 active site 216595014073 substrate binding site [chemical binding]; other site 216595014074 cosubstrate binding site; other site 216595014075 catalytic site [active] 216595014076 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 216595014077 active site 216595014078 hexamer interface [polypeptide binding]; other site 216595014079 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 216595014080 NAD binding site [chemical binding]; other site 216595014081 substrate binding site [chemical binding]; other site 216595014082 active site 216595014086 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 216595014087 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 216595014088 Ligand binding site [chemical binding]; other site 216595014089 Putative Catalytic site [active] 216595014090 DXD motif; other site 216595014092 1 probable transmembrane helix predicted for PFLU3043 by TMHMM2.0 at aa 13-32 216595014093 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 216595014094 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 216595014095 DNA binding site [nucleotide binding] 216595014096 Int/Topo IB signature motif; other site 216595014097 active site 216595014100 short chain dehydrogenase; Provisional; Region: PRK06701 216595014101 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 216595014102 NAD binding site [chemical binding]; other site 216595014103 metal binding site [ion binding]; metal-binding site 216595014104 active site 216595014106 PS00061 Short-chain dehydrogenases/reductases family signature. 216595014107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595014108 putative substrate translocation pore; other site 216595014110 PS00017 ATP/GTP-binding site motif A (P-loop). 216595014111 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595014112 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595014113 2 probable transmembrane helices predicted for PFLU3047 by TMHMM2.0 at aa 5-27 and 183-205 216595014116 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595014118 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216595014119 classical (c) SDRs; Region: SDR_c; cd05233 216595014120 NAD(P) binding site [chemical binding]; other site 216595014121 active site 216595014123 PS00061 Short-chain dehydrogenases/reductases family signature. 216595014124 low G+C content region (34.5%) 216595014125 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595014126 PS00017 ATP/GTP-binding site motif A (P-loop). 216595014127 Predicted transcriptional regulator [Transcription]; Region: COG2378 216595014128 low G+C content region (37.94%) 216595014129 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 216595014130 Cache domain; Region: Cache_2; cl07034 216595014131 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 216595014132 dimerization interface [polypeptide binding]; other site 216595014133 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595014134 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595014138 outer membrane porin, OprD family; Region: OprD; pfam03573 216595014140 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 216595014141 PS00017 ATP/GTP-binding site motif A (P-loop). 216595014142 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 216595014143 Citrate transporter; Region: CitMHS; pfam03600 216595014145 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 216595014147 PS00714 Sodium:dicarboxylate symporter family signature 2. 216595014148 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 216595014149 PS00713 Sodium:dicarboxylate symporter family signature 1. 216595014150 PrpF protein; Region: PrpF; pfam04303 216595014151 Translocon-associated protein (TRAP), alpha subunit; Region: TRAP_alpha; pfam03896 216595014153 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595014154 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595014155 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 216595014156 putative dimerization interface [polypeptide binding]; other site 216595014158 PS00044 Bacterial regulatory proteins, lysR family signature. 216595014160 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 216595014161 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 216595014163 PS00181 Glutamine synthetase putative ATP-binding region signature. 216595014164 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 216595014165 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 216595014166 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216595014167 catalytic residue [active] 216595014169 low G+C content region (35.83%) 216595014170 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216595014171 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595014172 NAD(P) binding site [chemical binding]; other site 216595014173 active site 216595014175 very low G+C content region (27.84%) 216595014176 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595014177 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595014178 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 216595014179 dimerization interface [polypeptide binding]; other site 216595014182 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595014183 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216595014185 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 216595014186 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 216595014188 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 216595014189 homotrimer interaction site [polypeptide binding]; other site 216595014190 putative active site [active] 216595014192 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595014193 Ornithine cyclodeaminase/mu-crystallin family; Region: OCD_Mu_crystall; pfam02423 216595014195 PS00017 ATP/GTP-binding site motif A (P-loop). 216595014196 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216595014197 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595014199 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216595014200 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595014201 active site 216595014202 phosphorylation site [posttranslational modification] 216595014203 intermolecular recognition site; other site 216595014204 dimerization interface [polypeptide binding]; other site 216595014205 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 216595014206 DNA binding site [nucleotide binding] 216595014209 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216595014210 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595014211 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595014212 dimer interface [polypeptide binding]; other site 216595014213 phosphorylation site [posttranslational modification] 216595014214 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595014215 ATP binding site [chemical binding]; other site 216595014216 Mg2+ binding site [ion binding]; other site 216595014217 G-X-G motif; other site 216595014218 2 probable transmembrane helices predicted for PFLU3075 by TMHMM2.0 at aa 13-35 and 55-77 216595014222 1 probable transmembrane helix predicted for PFLU3077 by TMHMM2.0 at aa 44-66 216595014223 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 216595014224 5 probable transmembrane helices predicted for PFLU3078 by TMHMM2.0 at aa 36-58, 73-92, 140-159, 163-182 and 231-253 216595014225 transcriptional regulator EutR; Provisional; Region: PRK10130 216595014226 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595014228 PS00041 Bacterial regulatory proteins, araC family signature. 216595014230 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 216595014232 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 216595014233 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595014234 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595014236 Protein of unknown function (DUF1185); Region: DUF1185; pfam06684 216595014238 The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6, and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348 216595014239 putative active site [active] 216595014240 putative metal binding site [ion binding]; other site 216595014242 PS00082 Extradiol ring-cleavage dioxygenases signature. 216595014243 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 216595014244 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 216595014245 Ycf48-like protein; Provisional; Region: PRK13684 216595014246 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 216595014253 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 216595014254 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595014255 NAD(P) binding site [chemical binding]; other site 216595014256 active site 216595014258 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 216595014259 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216595014260 NAD(P) binding site [chemical binding]; other site 216595014261 catalytic residues [active] 216595014263 PS00070 Aldehyde dehydrogenases cysteine active site. 216595014264 PS00687 Aldehyde dehydrogenases glutamic acid active site. 216595014265 hypothetical protein; Validated; Region: PRK07586 216595014266 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 216595014267 PYR/PP interface [polypeptide binding]; other site 216595014268 dimer interface [polypeptide binding]; other site 216595014269 TPP binding site [chemical binding]; other site 216595014270 TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of benzoylformate to benzaldehyde and carbon dioxide. This...; Region: TPP_BFDC; cd02002 216595014271 TPP-binding site [chemical binding]; other site 216595014272 dimer interface [polypeptide binding]; other site 216595014276 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595014277 Bacterial transcriptional regulator; Region: IclR; pfam01614 216595014280 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216595014281 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 216595014282 NAD(P) binding site [chemical binding]; other site 216595014283 catalytic residues [active] 216595014285 PS00070 Aldehyde dehydrogenases cysteine active site. 216595014286 PS00687 Aldehyde dehydrogenases glutamic acid active site. 216595014287 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 216595014289 Cache domain; Region: Cache_1; pfam02743 216595014290 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 216595014291 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 216595014292 dimerization interface [polypeptide binding]; other site 216595014293 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595014294 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595014295 2 probable transmembrane helices predicted for PFLU3092 by TMHMM2.0 at aa 10-32 and 330-352 216595014299 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 216595014300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595014301 putative substrate translocation pore; other site 216595014302 14 probable transmembrane helices predicted for PFLU3093 by TMHMM2.0 at aa 7-26, 46-68, 75-94, 104-126, 135-157, 162-184, 197-214, 224-242, 262-284, 299-321, 328-347, 352-374, 395-417 and 464-486 216595014304 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 216595014306 transcriptional regulator EutR; Provisional; Region: PRK10130 216595014307 PS00041 Bacterial regulatory proteins, araC family signature. 216595014308 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 216595014309 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 216595014310 inhibitor-cofactor binding pocket; inhibition site 216595014311 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595014312 catalytic residue [active] 216595014314 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 216595014315 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216595014316 NAD(P) binding site [chemical binding]; other site 216595014317 catalytic residues [active] 216595014319 PS00017 ATP/GTP-binding site motif A (P-loop). 216595014320 PS00687 Aldehyde dehydrogenases glutamic acid active site. 216595014321 PS00070 Aldehyde dehydrogenases cysteine active site. 216595014322 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 216595014324 4 probable transmembrane helices predicted for PFLU3098 by TMHMM2.0 at aa 30-47, 62-84, 111-133 and 157-179 216595014325 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 216595014326 Cupin domain; Region: Cupin_2; cl09118 216595014327 Peptidase family M48; Region: Peptidase_M48; cl12018 216595014329 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 216595014330 DNA helicase, putative; Region: TIGR00376 216595014331 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 216595014332 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 216595014333 PS00017 ATP/GTP-binding site motif A (P-loop). 216595014335 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 216595014336 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 216595014337 tetramer interface [polypeptide binding]; other site 216595014338 active site 216595014339 Mg2+/Mn2+ binding site [ion binding]; other site 216595014341 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216595014342 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 216595014343 putative active site [active] 216595014344 heme pocket [chemical binding]; other site 216595014345 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216595014346 putative active site [active] 216595014347 heme pocket [chemical binding]; other site 216595014348 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595014352 PS00017 ATP/GTP-binding site motif A (P-loop). 216595014353 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595014355 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 216595014356 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 216595014357 dimer interface [polypeptide binding]; other site 216595014358 active site 216595014360 PS00606 Beta-ketoacyl synthases active site. 216595014362 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 216595014363 homotrimer interaction site [polypeptide binding]; other site 216595014364 putative active site [active] 216595014366 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 216595014367 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 216595014368 Peptidase family U32; Region: Peptidase_U32; cl03113 216595014369 Collagenase; Region: DUF3656; pfam12392 216595014371 PS01276 Peptidase family U32 signature. 216595014372 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 216595014373 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 216595014374 EamA-like transporter family; Region: EamA; cl01037 216595014377 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 216595014378 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595014379 PS00519 Bacterial regulatory proteins, asnC family signature. 216595014381 5 probable transmembrane helices predicted for PFLU3114 by TMHMM2.0 at aa 20-39, 83-100, 110-132, 137-156 and 166-188 216595014382 D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 216595014383 D-xylulose kinase; Region: XylB; TIGR01312 216595014384 N- and C-terminal domain interface [polypeptide binding]; other site 216595014385 active site 216595014386 catalytic site [active] 216595014387 metal binding site [ion binding]; metal-binding site 216595014388 xylulose binding site [chemical binding]; other site 216595014389 putative ATP binding site [chemical binding]; other site 216595014390 homodimer interface [polypeptide binding]; other site 216595014393 PS00933 FGGY family of carbohydrate kinases signature 1. 216595014394 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216595014395 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216595014396 DNA binding site [nucleotide binding] 216595014397 domain linker motif; other site 216595014398 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 216595014399 dimerization interface [polypeptide binding]; other site 216595014400 ligand binding site [chemical binding]; other site 216595014403 PS00356 Bacterial regulatory proteins, lacI family signature. 216595014404 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 216595014405 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 216595014406 putative ligand binding site [chemical binding]; other site 216595014408 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216595014409 TM-ABC transporter signature motif; other site 216595014411 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 216595014412 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 216595014413 Walker A/P-loop; other site 216595014414 ATP binding site [chemical binding]; other site 216595014415 Q-loop/lid; other site 216595014416 ABC transporter signature motif; other site 216595014417 Walker B; other site 216595014418 D-loop; other site 216595014419 H-loop/switch region; other site 216595014420 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 216595014422 PS00211 ABC transporters family signature. 216595014424 PS00017 ATP/GTP-binding site motif A (P-loop). 216595014425 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 216595014427 Thermostable hemolysin; Region: T_hemolysin; pfam12261 216595014428 PS00141 Eukaryotic and viral aspartyl proteases active site. 216595014429 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 216595014430 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595014432 PS00455 Putative AMP-binding domain signature. 216595014433 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 216595014434 heme binding pocket [chemical binding]; other site 216595014435 heme ligand [chemical binding]; other site 216595014436 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 216595014437 classical (c) SDRs; Region: SDR_c; cd05233 216595014438 NAD(P) binding site [chemical binding]; other site 216595014439 active site 216595014441 1 probable transmembrane helix predicted for PFLU3124 by TMHMM2.0 at aa 13-35 216595014442 PS00061 Short-chain dehydrogenases/reductases family signature. 216595014444 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 216595014445 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595014446 active site 216595014447 phosphorylation site [posttranslational modification] 216595014448 intermolecular recognition site; other site 216595014449 dimerization interface [polypeptide binding]; other site 216595014450 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 216595014451 DNA binding site [nucleotide binding] 216595014454 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216595014455 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595014456 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595014457 dimer interface [polypeptide binding]; other site 216595014458 phosphorylation site [posttranslational modification] 216595014459 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595014460 ATP binding site [chemical binding]; other site 216595014461 Mg2+ binding site [ion binding]; other site 216595014462 G-X-G motif; other site 216595014463 2 probable transmembrane helices predicted for PFLU3127 by TMHMM2.0 at aa 10-29 and 166-188 216595014467 PAS domain S-box; Region: sensory_box; TIGR00229 216595014468 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 216595014469 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595014470 dimer interface [polypeptide binding]; other site 216595014471 phosphorylation site [posttranslational modification] 216595014472 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595014473 ATP binding site [chemical binding]; other site 216595014474 Mg2+ binding site [ion binding]; other site 216595014475 G-X-G motif; other site 216595014479 Response regulator receiver domain; Region: Response_reg; pfam00072 216595014480 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595014481 active site 216595014482 phosphorylation site [posttranslational modification] 216595014483 intermolecular recognition site; other site 216595014484 dimerization interface [polypeptide binding]; other site 216595014486 Response regulator receiver domain; Region: Response_reg; pfam00072 216595014487 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595014488 active site 216595014489 phosphorylation site [posttranslational modification] 216595014490 intermolecular recognition site; other site 216595014491 dimerization interface [polypeptide binding]; other site 216595014492 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216595014495 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 216595014496 sodium/hydrogen exchanger 3; Region: b_cpa1; TIGR00840 216595014497 12 probable transmembrane helices predicted for PFLU3131 by TMHMM2.0 at aa 15-37, 44-66, 81-98, 105-127, 132-154, 167-189, 209-228, 248-270, 339-361, 368-390, 400-422 and 427-446 216595014499 Uncharacterized conserved protein [Function unknown]; Region: COG2308 216595014500 Domain of unknown function (DUF404); Region: DUF404; pfam04169 216595014501 Domain of unknown function (DUF407); Region: DUF407; pfam04174 216595014504 Bacterial domain of unknown function (DUF403); Region: DUF403; cl00980 216595014506 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595014507 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216595014509 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 216595014510 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595014511 DEAD_2; Region: DEAD_2; cl14887 216595014512 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595014514 PS00690 DEAH-box subfamily ATP-dependent helicases signature. 216595014515 PS00017 ATP/GTP-binding site motif A (P-loop). 216595014516 VRR-NUC domain; Region: VRR_NUC; cl08494 216595014518 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 216595014520 1 probable transmembrane helix predicted for PFLU3140 by TMHMM2.0 at aa 7-29 216595014521 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595014522 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 216595014523 nucleophilic elbow; other site 216595014524 catalytic triad; other site 216595014525 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 216595014526 PS00012 Phosphopantetheine attachment site. 216595014528 PS00330 Hemolysin-type calcium-binding region signature. 216595014531 PS00120 Lipases, serine active site. 216595014532 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 216595014533 Outer membrane efflux protein; Region: OEP; pfam02321 216595014534 Outer membrane efflux protein; Region: OEP; pfam02321 216595014537 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 216595014538 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404 216595014540 1 probable transmembrane helix predicted for PFLU3143 by TMHMM2.0 at aa 21-40 216595014541 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 216595014542 This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export...; Region: ABCC_Protease_Secretion; cd03246 216595014543 Walker A/P-loop; other site 216595014544 ATP binding site [chemical binding]; other site 216595014545 Q-loop/lid; other site 216595014546 ABC transporter signature motif; other site 216595014547 Walker B; other site 216595014548 D-loop; other site 216595014549 H-loop/switch region; other site 216595014551 PS00211 ABC transporters family signature. 216595014552 PS00017 ATP/GTP-binding site motif A (P-loop). 216595014553 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595014554 Protease inhibitor Inh; Region: Inh; pfam02974 216595014556 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 216595014557 active site 216595014558 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 216595014560 PS00330 Hemolysin-type calcium-binding region signature. 216595014564 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 216595014565 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 216595014566 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 216595014567 homodimer interface [polypeptide binding]; other site 216595014568 homotetramer interface [polypeptide binding]; other site 216595014569 active site pocket [active] 216595014570 cleavage site 216595014572 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 216595014574 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 216595014575 DNA binding residues [nucleotide binding] 216595014576 dimerization interface [polypeptide binding]; other site 216595014578 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 216595014579 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595014581 PS00017 ATP/GTP-binding site motif A (P-loop). 216595014582 Cupin domain; Region: Cupin_2; cl09118 216595014584 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 216595014585 FAD dependent oxidoreductase; Region: DAO; pfam01266 216595014587 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 216595014588 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216595014589 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595014591 PS00041 Bacterial regulatory proteins, araC family signature. 216595014592 Protein of unknown function (DUF1652); Region: DUF1652; pfam07865 216595014594 flagellar assembly protein H; Provisional; Region: fliH; PRK13386 216595014595 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 216595014596 UvrD/REP helicase; Region: UvrD-helicase; cl14126 216595014597 DNA helicase IV; Provisional; Region: helD; PRK11054 216595014598 UvrD/REP helicase; Region: UvrD-helicase; cl14126 216595014600 PS00017 ATP/GTP-binding site motif A (P-loop). 216595014601 Pirin-related protein [General function prediction only]; Region: COG1741 216595014602 Cupin domain; Region: Cupin_2; cl09118 216595014605 phosphoglucomutase; Validated; Region: PRK07564 216595014606 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2)...; Region: phosphohexomutase; cl03757 216595014607 active site 216595014608 substrate binding site [chemical binding]; other site 216595014609 metal binding site [ion binding]; metal-binding site 216595014612 PS00017 ATP/GTP-binding site motif A (P-loop). 216595014615 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 216595014616 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 216595014617 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595014618 DNA-binding site [nucleotide binding]; DNA binding site 216595014619 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 216595014620 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216595014621 catalytic residue [active] 216595014624 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 216595014625 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 216595014626 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 216595014627 putative NAD(P) binding site [chemical binding]; other site 216595014630 PS00059 Zinc-containing alcohol dehydrogenases signature. 216595014631 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595014632 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595014633 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 216595014634 putative substrate binding pocket [chemical binding]; other site 216595014635 putative dimerization interface [polypeptide binding]; other site 216595014638 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 216595014639 4 probable transmembrane helices predicted for PFLU3165 by TMHMM2.0 at aa 35-57, 72-94, 154-176 and 196-215 216595014641 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 216595014642 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 216595014643 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 216595014644 putative hydrophobic ligand binding site [chemical binding]; other site 216595014645 protein interface [polypeptide binding]; other site 216595014646 gate; other site 216595014647 Flavin Reductases; Region: FlaRed; cl00801 216595014649 1 probable transmembrane helix predicted for PFLU3170 by TMHMM2.0 at aa 15-37 216595014650 short chain dehydrogenase; Provisional; Region: PRK12939 216595014651 classical (c) SDRs; Region: SDR_c; cd05233 216595014652 NAD(P) binding site [chemical binding]; other site 216595014653 active site 216595014655 PS00061 Short-chain dehydrogenases/reductases family signature. 216595014656 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 216595014657 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 216595014658 FMN binding site [chemical binding]; other site 216595014659 active site 216595014660 substrate binding site [chemical binding]; other site 216595014661 catalytic residue [active] 216595014663 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216595014664 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216595014667 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216595014668 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216595014670 hypothetical protein; Validated; Region: PRK07682 216595014671 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216595014672 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595014673 homodimer interface [polypeptide binding]; other site 216595014674 catalytic residue [active] 216595014676 PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 216595014677 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595014678 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 216595014679 NAD(P) binding site [chemical binding]; other site 216595014680 active site 216595014682 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 216595014683 NAD binding site [chemical binding]; other site 216595014684 active site 216595014686 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216595014687 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216595014689 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595014690 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595014691 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 216595014692 putative dimerization interface [polypeptide binding]; other site 216595014695 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 216595014696 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 216595014697 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595014699 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 216595014700 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 216595014701 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 216595014702 active site 216595014703 FMN binding site [chemical binding]; other site 216595014704 substrate binding site [chemical binding]; other site 216595014705 homotetramer interface [polypeptide binding]; other site 216595014706 catalytic residue [active] 216595014708 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595014710 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 216595014711 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 216595014713 PS00462 Gamma-glutamyltranspeptidase signature. 216595014714 1 probable transmembrane helix predicted for PFLU3186 by TMHMM2.0 at aa 39-56 216595014715 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 216595014717 PS00714 Sodium:dicarboxylate symporter family signature 2. 216595014718 PS00713 Sodium:dicarboxylate symporter family signature 1. 216595014719 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 216595014720 putative metal binding site [ion binding]; other site 216595014722 haemagglutination activity domain; Region: Haemagg_act; cl05436 216595014723 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 216595014724 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cd00081 216595014725 protein-splicing catalytic site; other site 216595014726 thioester formation/cholesterol transfer; other site 216595014727 Protein of unknown function (DUF1557); Region: DUF1557; pfam07591 216595014735 PS00017 ATP/GTP-binding site motif A (P-loop). 216595014761 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 216595014762 Surface antigen; Region: Bac_surface_Ag; cl03097 216595014765 2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012 216595014766 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 216595014767 dimer interface [polypeptide binding]; other site 216595014768 TPP-binding site [chemical binding]; other site 216595014769 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 216595014770 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216595014771 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595014772 NAD(P) binding site [chemical binding]; other site 216595014773 active site 216595014775 PS00061 Short-chain dehydrogenases/reductases family signature. 216595014776 D-lactate dehydrogenase [cytochrome]; Region: PLN02805 216595014777 FAD binding domain; Region: FAD_binding_4; pfam01565 216595014780 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 216595014781 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 216595014783 PS00017 ATP/GTP-binding site motif A (P-loop). 216595014784 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 216595014785 active site 216595014787 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216595014788 active site 216595014792 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 216595014793 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 216595014794 dimer interface [polypeptide binding]; other site 216595014795 active site 216595014798 PS00606 Beta-ketoacyl synthases active site. 216595014799 Phosphopantetheine attachment site; Region: PP-binding; cl09936 216595014801 PS00012 Phosphopantetheine attachment site. 216595014802 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 216595014803 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 216595014804 dimer interface [polypeptide binding]; other site 216595014805 active site 216595014806 CoA binding pocket [chemical binding]; other site 216595014809 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 216595014810 EamA-like transporter family; Region: EamA; cl01037 216595014813 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595014814 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216595014815 non-specific DNA binding site [nucleotide binding]; other site 216595014816 salt bridge; other site 216595014817 sequence-specific DNA binding site [nucleotide binding]; other site 216595014819 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 216595014820 Golgi 4-transmembrane spanning transporter; Region: Mtp; cl04276 216595014822 PS00041 Bacterial regulatory proteins, araC family signature. 216595014824 Protein involved in meta-pathway of phenol degradation [Energy production and conversion]; Region: COG4313 216595014825 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 216595014826 indole acetimide hydrolase; Validated; Region: PRK07488 216595014828 PS00571 Amidases signature. 216595014829 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 216595014830 TOMM propeptide domain; Region: TOMM_pelo; TIGR03793 216595014832 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 216595014833 nitrile hydratase, beta subunit; Region: nitrile_beta; cl03486 216595014835 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 216595014836 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 216595014837 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 216595014839 PS00017 ATP/GTP-binding site motif A (P-loop). 216595014841 PAS fold; Region: PAS_3; pfam08447 216595014842 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 216595014846 acetyl-CoA synthetase; Provisional; Region: PRK04319 216595014847 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595014849 PS00455 Putative AMP-binding domain signature. 216595014850 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216595014851 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216595014853 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 216595014854 Protein export membrane protein; Region: SecD_SecF; cl14618 216595014856 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 216595014858 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595014859 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 216595014860 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 216595014861 inhibitor-cofactor binding pocket; inhibition site 216595014862 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595014863 catalytic residue [active] 216595014865 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 216595014866 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 216595014867 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216595014868 N-terminal plug; other site 216595014869 ligand-binding site [chemical binding]; other site 216595014872 PFI-7 216595014873 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 216595014875 peptide synthase; Validated; Region: PRK05691 216595014876 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595014877 Condensation domain; Region: Condensation; cl09290 216595014879 PS00211 ABC transporters family signature. 216595014880 PS00455 Putative AMP-binding domain signature. 216595014883 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 216595014885 Condensation domain; Region: Condensation; cl09290 216595014886 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 216595014887 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216595014888 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595014889 Phosphopantetheine attachment site; Region: PP-binding; cl09936 216595014892 PS00455 Putative AMP-binding domain signature. 216595014894 PS00012 Phosphopantetheine attachment site. 216595014895 peptide synthase; Validated; Region: PRK05691 216595014896 Condensation domain; Region: Condensation; cl09290 216595014897 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595014898 Phosphopantetheine attachment site; Region: PP-binding; cl09936 216595014899 Condensation domain; Region: Condensation; cl09290 216595014900 L-aminoadipate-semialdehyde dehydrogenase; Region: alpha_am_amid; TIGR03443 216595014901 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216595014902 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595014903 Phosphopantetheine attachment site; Region: PP-binding; cl09936 216595014904 Condensation domain; Region: Condensation; cl09290 216595014905 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 216595014906 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595014907 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595014908 Phosphopantetheine attachment site; Region: PP-binding; cl09936 216595014909 Condensation domain; Region: Condensation; cl09290 216595014910 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216595014911 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595014912 Phosphopantetheine attachment site; Region: PP-binding; cl09936 216595014913 Condensation domain; Region: Condensation; cl09290 216595014914 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 216595014917 PS00455 Putative AMP-binding domain signature. 216595014918 PS00904 Protein prenyltransferases alpha subunit repeat signature. 216595014920 PS00012 Phosphopantetheine attachment site. 216595014923 PS00455 Putative AMP-binding domain signature. 216595014927 PS00455 Putative AMP-binding domain signature. 216595014929 PS00012 Phosphopantetheine attachment site. 216595014932 PS00455 Putative AMP-binding domain signature. 216595014934 PS00012 Phosphopantetheine attachment site. 216595014936 Condensation domain; Region: Condensation; cl09290 216595014937 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 216595014938 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595014939 Phosphopantetheine attachment site; Region: PP-binding; cl09936 216595014940 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 216595014941 Condensation domain; Region: Condensation; cl09290 216595014942 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 216595014943 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595014944 Phosphopantetheine attachment site; Region: PP-binding; cl09936 216595014945 Condensation domain; Region: Condensation; cl09290 216595014946 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 216595014947 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 216595014950 PS00455 Putative AMP-binding domain signature. 216595014955 PS00455 Putative AMP-binding domain signature. 216595014956 PS00904 Protein prenyltransferases alpha subunit repeat signature. 216595014958 PS00012 Phosphopantetheine attachment site. 216595014961 Condensation domain; Region: Condensation; cl09290 216595014962 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216595014963 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595014964 Phosphopantetheine attachment site; Region: PP-binding; cl09936 216595014965 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 216595014968 PS00455 Putative AMP-binding domain signature. 216595014971 ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615 216595014972 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with...; Region: ABCC_MRP_Like; cd03228 216595014973 Walker A/P-loop; other site 216595014974 ATP binding site [chemical binding]; other site 216595014975 Q-loop/lid; other site 216595014976 ABC transporter signature motif; other site 216595014977 Walker B; other site 216595014978 D-loop; other site 216595014979 H-loop/switch region; other site 216595014980 6 probable transmembrane helices predicted for PFLU3226 by TMHMM2.0 at aa 12-34, 49-68, 122-144, 149-166, 231-253 and 268-290 216595014981 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 216595014983 PS00017 ATP/GTP-binding site motif A (P-loop). 216595014984 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595014985 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 216595014986 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 216595014987 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 216595014988 Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223 216595014989 5 probable transmembrane helices predicted for PFLU3228 by TMHMM2.0 at aa 21-43, 65-87, 144-166, 181-203 and 274-296 216595014991 PS00017 ATP/GTP-binding site motif A (P-loop). 216595014993 Pectate lyase; Region: Pec_lyase_C; cl01593 216595014994 1 probable transmembrane helix predicted for PFLU3229 by TMHMM2.0 at aa 12-34 216595014996 type II secretion system secreton cluster 2 216595014997 general secretion pathway protein F; Region: GspF; TIGR02120 216595014998 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 216595014999 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 216595015002 general secretory pathway protein E; Region: type_II_gspE; TIGR02533 216595015003 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 216595015004 Walker A motif; other site 216595015005 ATP binding site [chemical binding]; other site 216595015006 Walker B motif; other site 216595015008 PS00662 Bacterial type II secretion system protein E signature. 216595015009 PS00017 ATP/GTP-binding site motif A (P-loop). 216595015010 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 216595015011 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 216595015012 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 216595015013 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 216595015014 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 216595015019 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595015020 General secretion pathway, M protein; Region: GspM; cl01222 216595015022 1 probable transmembrane helix predicted for PFLU3233 by TMHMM2.0 at aa 49-66 216595015023 general secretion pathway protein L; Region: typeII_sec_gspL; TIGR01709 216595015024 GspL periplasmic domain; Region: GspL_C; cl14909 216595015026 General secretion pathway protein K; Region: GspK; pfam03934 216595015028 1 probable transmembrane helix predicted for PFLU3235 by TMHMM2.0 at aa 13-35 216595015029 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 216595015030 general secretion pathway protein G; Region: typeII_sec_gspG; TIGR01710 216595015031 Bacterial type II secretion system protein G; Region: GSPII_G; pfam08334 216595015034 1 probable transmembrane helix predicted for PFLU3236 by TMHMM2.0 at aa 21-43 216595015035 PS00409 Prokaryotic N-terminal methylation site. 216595015036 Bacterial type II secretion system protein I/J; Region: GSPII_IJ; pfam02501 216595015038 PS00409 Prokaryotic N-terminal methylation site. 216595015039 1 probable transmembrane helix predicted for PFLU3237 by TMHMM2.0 at aa 12-34 216595015041 general secretion pathway protein H; Region: typeII_sec_gspH; TIGR01708 216595015042 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 216595015044 PS00409 Prokaryotic N-terminal methylation site. 216595015045 1 probable transmembrane helix predicted for PFLU3239 by TMHMM2.0 at aa 20-42 216595015046 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 216595015047 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 216595015048 Pseudopilin GspJ; Region: GspJ; pfam11612 216595015050 PS00409 Prokaryotic N-terminal methylation site. 216595015051 1 probable transmembrane helix predicted for PFLU3240 by TMHMM2.0 at aa 7-29 216595015052 PS00018 EF-hand calcium-binding domain. 216595015053 haemagglutination activity domain; Region: Haemagg_act; cl05436 216595015054 PS00017 ATP/GTP-binding site motif A (P-loop). 216595015055 PS00107 Protein kinases ATP-binding region signature. 216595015084 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 216595015085 Surface antigen; Region: Bac_surface_Ag; cl03097 216595015088 radical SAM pair-associated protein; Region: chp_LLNDYxLRE; TIGR03976 216595015089 His-Xaa-Ser repeat-associated upstream radical SAM protein; Region: rSAM_paired_1; TIGR03978 216595015090 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 216595015091 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085 216595015093 His-Xaa-Ser repeat-associated downstream radical SAM protein; Region: rSAM_paired_2; TIGR03977 216595015094 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 216595015095 FeS/SAM binding site; other site 216595015097 His/Ser-rich radical SAM pair-associated protein; Region: His_Ser_Rich; TIGR03979 216595015098 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 216595015100 6 probable transmembrane helices predicted for PFLU3253 by TMHMM2.0 at aa 50-67, 77-99, 112-131, 146-168, 170-189 and 209-231 216595015101 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216595015102 metal binding site [ion binding]; metal-binding site 216595015103 active site 216595015104 I-site; other site 216595015105 4 probable transmembrane helices predicted for PFLU3255 by TMHMM2.0 at aa 36-58, 62-83, 100-122 and 175-197 216595015107 Cytochrome P450; Region: p450; cl12078 216595015108 PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 216595015109 PS00237 G-protein coupled receptors signature. 216595015110 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216595015111 putative DNA binding site [nucleotide binding]; other site 216595015112 dimerization interface [polypeptide binding]; other site 216595015113 putative Zn2+ binding site [ion binding]; other site 216595015115 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 216595015116 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595015117 Walker A/P-loop; other site 216595015118 ATP binding site [chemical binding]; other site 216595015119 Q-loop/lid; other site 216595015120 ABC transporter signature motif; other site 216595015121 Walker B; other site 216595015122 D-loop; other site 216595015123 H-loop/switch region; other site 216595015125 PS00211 ABC transporters family signature. 216595015126 PS00017 ATP/GTP-binding site motif A (P-loop). 216595015127 transcriptional regulator; Provisional; Region: PRK10632 216595015128 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595015129 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 216595015130 putative effector binding pocket; other site 216595015131 dimerization interface [polypeptide binding]; other site 216595015134 PS00044 Bacterial regulatory proteins, lysR family signature. 216595015135 Arginase family; Region: Arginase; cl00306 216595015137 PS00148 Arginase family signature 2. 216595015138 amidase; Provisional; Region: PRK07869 216595015139 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 216595015141 PS00571 Amidases signature. 216595015142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595015144 PS00216 Sugar transport proteins signature 1. 216595015145 Protein involved in meta-pathway of phenol degradation [Energy production and conversion]; Region: COG4313 216595015146 transcriptional regulator EutR; Provisional; Region: PRK10130 216595015147 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595015149 PS00041 Bacterial regulatory proteins, araC family signature. 216595015151 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595015152 Transcriptional regulators [Transcription]; Region: MarR; COG1846 216595015154 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 216595015155 Cupin domain; Region: Cupin_2; cl09118 216595015156 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595015159 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 216595015161 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 216595015162 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 216595015164 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216595015165 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 216595015166 NAD binding site [chemical binding]; other site 216595015167 catalytic residues [active] 216595015169 PS00687 Aldehyde dehydrogenases glutamic acid active site. 216595015170 PS00070 Aldehyde dehydrogenases cysteine active site. 216595015171 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 216595015172 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 216595015173 putative active site [active] 216595015174 putative metal binding site [ion binding]; other site 216595015176 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 216595015177 putative substrate binding pocket [chemical binding]; other site 216595015178 trimer interface [polypeptide binding]; other site 216595015180 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 216595015181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595015182 putative substrate translocation pore; other site 216595015183 12 probable transmembrane helices predicted for PFLU3274 by TMHMM2.0 at aa 21-40, 60-79, 92-111, 116-138, 150-172, 182-204, 249-271, 286-305, 318-337, 341-363, 375-397 and 407-424 216595015185 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 216595015187 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 216595015188 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 216595015190 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595015192 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 216595015193 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 216595015195 PS00626 Regulator of chromosome condensation (RCC1) signature 2. 216595015196 Cupin domain; Region: Cupin_2; cl09118 216595015198 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 216595015199 DNA binding residues [nucleotide binding] 216595015200 dimerization interface [polypeptide binding]; other site 216595015202 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 216595015203 classical (c) SDRs; Region: SDR_c; cd05233 216595015204 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 216595015205 NAD(P) binding site [chemical binding]; other site 216595015206 active site 216595015208 PS00061 Short-chain dehydrogenases/reductases family signature. 216595015209 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 216595015210 classical (c) SDRs; Region: SDR_c; cd05233 216595015211 NAD(P) binding site [chemical binding]; other site 216595015212 active site 216595015214 PS00061 Short-chain dehydrogenases/reductases family signature. 216595015215 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216595015216 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216595015218 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 216595015219 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595015221 PS00041 Bacterial regulatory proteins, araC family signature. 216595015222 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 216595015223 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 216595015224 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 216595015227 Flavin Reductases; Region: FlaRed; cl00801 216595015228 phenylalanyl-tRNA synthetase subunit alpha; Provisional; Region: pheS; PRK04172 216595015230 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 216595015231 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216595015232 Flavin binding site [chemical binding]; other site 216595015234 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 216595015235 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216595015236 NAD(P) binding site [chemical binding]; other site 216595015237 catalytic residues [active] 216595015239 PS00070 Aldehyde dehydrogenases cysteine active site. 216595015240 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 216595015241 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595015242 NAD(P) binding site [chemical binding]; other site 216595015243 active site 216595015245 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 216595015246 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 216595015247 iron-sulfur cluster [ion binding]; other site 216595015248 [2Fe-2S] cluster binding site [ion binding]; other site 216595015249 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 216595015250 alpha subunit interface [polypeptide binding]; other site 216595015251 active site 216595015252 substrate binding site [chemical binding]; other site 216595015253 Fe binding site [ion binding]; other site 216595015255 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 216595015256 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-...; Region: PDR_like; cd06185 216595015257 FMN-binding pocket [chemical binding]; other site 216595015258 flavin binding motif; other site 216595015259 phosphate binding motif [ion binding]; other site 216595015260 beta-alpha-beta structure motif; other site 216595015261 NAD binding pocket [chemical binding]; other site 216595015262 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216595015263 catalytic loop [active] 216595015264 iron binding site [ion binding]; other site 216595015268 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 216595015269 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 216595015270 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595015271 DNA-binding site [nucleotide binding]; DNA binding site 216595015272 FCD domain; Region: FCD; cl11656 216595015275 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 216595015276 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 216595015277 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216595015278 active site 216595015279 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 216595015282 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 216595015283 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 216595015284 dimer interface [polypeptide binding]; other site 216595015285 active site 216595015287 PS00099 Thiolases active site. 216595015288 PS00737 Thiolases signature 2. 216595015290 feruloyl-CoA synthase; Reviewed; Region: PRK08180 216595015292 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216595015293 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 216595015294 NAD(P) binding site [chemical binding]; other site 216595015295 catalytic residues [active] 216595015297 PS00687 Aldehyde dehydrogenases glutamic acid active site. 216595015298 PS00070 Aldehyde dehydrogenases cysteine active site. 216595015299 p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120 216595015300 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 216595015301 substrate binding site [chemical binding]; other site 216595015302 oxyanion hole (OAH) forming residues; other site 216595015303 trimer interface [polypeptide binding]; other site 216595015305 PS00166 Enoyl-CoA hydratase/isomerase signature. 216595015306 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595015308 outer membrane porin, OprD family; Region: OprD; pfam03573 216595015310 low G+C content region (38.56%) 216595015311 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 216595015312 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595015313 12 probable transmembrane helices predicted for PFLU3303 by TMHMM2.0 at aa 12-34, 47-69, 76-95, 100-122, 135-157, 161-183, 219-241, 251-273, 278-297, 302-324, 337-359 and 369-391 216595015315 PS00216 Sugar transport proteins signature 1. 216595015316 PS00217 Sugar transport proteins signature 2. 216595015317 Protein involved in meta-pathway of phenol degradation [Energy production and conversion]; Region: COG4313 216595015318 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595015319 NAD(P) binding site [chemical binding]; other site 216595015320 3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428 216595015321 active site 216595015323 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216595015324 NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152 216595015325 NAD(P) binding site [chemical binding]; other site 216595015326 catalytic residues [active] 216595015328 PS00687 Aldehyde dehydrogenases glutamic acid active site. 216595015329 Activator of aromatic catabolism; Region: XylR_N; pfam06505 216595015330 Heme NO binding; Region: HNOB; cl15268 216595015331 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595015332 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 216595015333 Walker A motif; other site 216595015334 ATP binding site [chemical binding]; other site 216595015335 Walker B motif; other site 216595015336 arginine finger; other site 216595015340 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 216595015341 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 216595015343 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216595015344 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216595015346 PS01081 Bacterial regulatory proteins, tetR family signature. 216595015347 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 216595015348 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595015350 PS00107 Protein kinases ATP-binding region signature. 216595015351 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 216595015352 Beta-lactamase; Region: Beta-lactamase; cl01009 216595015354 Isochorismatase family; Region: Isochorismatase; pfam00857 216595015355 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 216595015356 catalytic triad [active] 216595015357 conserved cis-peptide bond; other site 216595015359 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 216595015360 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14263 216595015361 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 216595015362 Walker A/P-loop; other site 216595015363 ATP binding site [chemical binding]; other site 216595015364 Q-loop/lid; other site 216595015365 ABC transporter signature motif; other site 216595015366 Walker B; other site 216595015367 D-loop; other site 216595015368 H-loop/switch region; other site 216595015370 PS00211 ABC transporters family signature. 216595015371 PS00017 ATP/GTP-binding site motif A (P-loop). 216595015372 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 216595015373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595015374 dimer interface [polypeptide binding]; other site 216595015375 conserved gate region; other site 216595015376 putative PBP binding loops; other site 216595015377 ABC-ATPase subunit interface; other site 216595015379 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 216595015380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595015381 dimer interface [polypeptide binding]; other site 216595015382 conserved gate region; other site 216595015383 putative PBP binding loops; other site 216595015384 ABC-ATPase subunit interface; other site 216595015386 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595015387 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595015389 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 216595015391 trehalose synthase, Pseudomonas stutzeri type; Region: TreS_stutzeri; TIGR02455 216595015392 PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. 216595015393 PAS fold; Region: PAS_4; pfam08448 216595015394 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216595015395 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595015397 PS00041 Bacterial regulatory proteins, araC family signature. 216595015399 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 216595015400 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 216595015401 14 probable transmembrane helices predicted for PFLU3323 by TMHMM2.0 at aa 12-34, 44-66, 86-108, 130-152, 159-181, 201-223, 236-258, 281-303, 337-359, 364-386, 399-421, 425-447, 460-482 and 492-514 216595015403 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 216595015404 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 216595015406 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 216595015407 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 216595015408 inhibitor site; inhibition site 216595015409 active site 216595015410 dimer interface [polypeptide binding]; other site 216595015411 catalytic residue [active] 216595015413 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216595015414 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 216595015415 dimer interface [polypeptide binding]; other site 216595015416 NADP binding site [chemical binding]; other site 216595015417 catalytic residues [active] 216595015419 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 216595015420 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 216595015422 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 216595015423 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 216595015424 conserved cys residue [active] 216595015428 LysE type translocator; Region: LysE; cl00565 216595015430 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 216595015431 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595015432 HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 216595015433 dimerization interface [polypeptide binding]; other site 216595015434 substrate binding pocket [chemical binding]; other site 216595015435 PS00228 Tubulin-beta mRNA autoregulation signal. 216595015438 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 216595015439 EamA-like transporter family; Region: EamA; cl01037 216595015440 EamA-like transporter family; Region: EamA; cl01037 216595015441 9 probable transmembrane helices predicted for PFLU3331 by TMHMM2.0 at aa 4-23, 30-52, 57-76, 89-108, 112-130, 137-159, 169-191, 204-226 and 241-263 216595015443 short chain dehydrogenase; Provisional; Region: PRK06123 216595015444 classical (c) SDRs; Region: SDR_c; cd05233 216595015445 NAD(P) binding site [chemical binding]; other site 216595015446 active site 216595015448 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216595015449 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216595015451 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 216595015452 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 216595015453 FMN binding site [chemical binding]; other site 216595015454 active site 216595015455 substrate binding site [chemical binding]; other site 216595015456 catalytic residue [active] 216595015458 short chain dehydrogenase; Provisional; Region: PRK06181 216595015459 classical (c) SDRs; Region: SDR_c; cd05233 216595015460 NAD(P) binding site [chemical binding]; other site 216595015461 active site 216595015463 PS00061 Short-chain dehydrogenases/reductases family signature. 216595015464 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 216595015465 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 216595015466 putative NAD(P) binding site [chemical binding]; other site 216595015469 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 216595015470 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 216595015471 NADP binding site [chemical binding]; other site 216595015472 active site 216595015473 steroid binding site; other site 216595015475 PFI-8 216595015477 1 probable transmembrane helix predicted for PFLU3344 by TMHMM2.0 at aa 10-32 216595015478 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 216595015479 Y-family of DNA polymerases; Region: PolY; cl12025 216595015481 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 216595015482 DNA binding site [nucleotide binding] 216595015483 Int/Topo IB signature motif; other site 216595015484 active site 216595015486 Anti-sigma-K factor rskA; Region: RskA; cl02208 216595015487 1 probable transmembrane helix predicted for PFLU3348 by TMHMM2.0 at aa 88-110 216595015488 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 216595015489 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216595015490 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 216595015492 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595015494 Fasciclin domain; Region: Fasciclin; cl02663 216595015496 1 probable transmembrane helix predicted for PFLU3350 by TMHMM2.0 at aa 9-31 216595015497 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595015498 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595015499 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595015502 Penicillin amidase; Region: Penicil_amidase; pfam01804 216595015503 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 216595015504 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and 7-...; Region: Ntn_CA; cd01936 216595015505 active site 216595015506 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 216595015508 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595015509 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595015510 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595015511 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 216595015512 putative effector binding pocket; other site 216595015513 putative dimerization interface [polypeptide binding]; other site 216595015516 PS00044 Bacterial regulatory proteins, lysR family signature. 216595015517 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 216595015518 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 216595015519 active site 216595015520 catalytic tetrad [active] 216595015522 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595015523 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595015524 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595015525 3 probable transmembrane helices predicted for PFLU3358 by TMHMM2.0 at aa 13-35, 280-302 and 309-331 216595015528 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 216595015529 hydrophobic ligand binding site; other site 216595015530 Protein of unknown function, DUF; Region: DUF411; cl01142 216595015532 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 216595015533 4 probable transmembrane helices predicted for PFLU3361 by TMHMM2.0 at aa 5-23, 38-60, 91-113 and 123-145 216595015535 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216595015536 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595015537 PS00017 ATP/GTP-binding site motif A (P-loop). 216595015539 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 216595015540 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595015543 PS00017 ATP/GTP-binding site motif A (P-loop). 216595015544 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 216595015545 PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 216595015547 glycogen synthase; Provisional; Region: glgA; PRK00654 216595015548 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 216595015549 ADP-binding pocket [chemical binding]; other site 216595015550 homodimer interface [polypeptide binding]; other site 216595015553 Maltooligosyl trehalose synthase (MTSase) N-terminus domain. MTSase and maltooligosyl trehalose trehalohydrolase (MTHase) work together to produce trehalose. MTSase is responsible for converting the alpha-1,4-glucosidic linkage to an alpha,alpha-1,1-...; Region: MTHase_N_term; cd02853 216595015554 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 216595015555 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 216595015556 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 216595015559 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 216595015560 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 216595015562 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 216595015563 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 216595015565 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 216595015566 Glycogen_debranching_enzyme N-terminal domain. Glycogen debranching enzymes have both 4-alpha-glucanotransferase and amylo-1,6-glucosidase activities. As a transferase it transfers a segment of a 1,4-alpha-D-glucan to a new 4-position in an acceptor...; Region: Glycogen_debranching_enzyme_N_term; cd02856 216595015567 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 216595015570 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216595015571 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 216595015573 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 216595015575 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 216595015576 DXD motif; other site 216595015578 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 216595015580 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 216595015581 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 216595015583 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 216595015585 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595015587 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 216595015588 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216595015589 N-terminal plug; other site 216595015590 ligand-binding site [chemical binding]; other site 216595015593 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595015594 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595015595 5 probable transmembrane helices predicted for PFLU3379 by TMHMM2.0 at aa 17-35, 39-61, 82-104, 108-125 and 146-168 216595015597 NmrA-like family; Region: NmrA; pfam05368 216595015598 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 216595015599 NADP binding site [chemical binding]; other site 216595015600 active site 216595015601 regulatory binding site [polypeptide binding]; other site 216595015603 LysR family transcriptional regulator; Provisional; Region: PRK14997 216595015604 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595015605 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 216595015606 putative effector binding pocket; other site 216595015607 dimerization interface [polypeptide binding]; other site 216595015609 PS00044 Bacterial regulatory proteins, lysR family signature. 216595015611 10 probable transmembrane helices predicted for PFLU3382 by TMHMM2.0 at aa 13-35, 45-67, 80-102, 107-129, 136-155, 165-187, 199-221, 231-253, 265-282 and 287-306 216595015614 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595015615 metabolite-proton symporter; Region: 2A0106; TIGR00883 216595015616 putative substrate translocation pore; other site 216595015617 12 probable transmembrane helices predicted for PFLU3383 by TMHMM2.0 at aa 45-67, 87-109, 122-144, 149-171, 184-206, 216-238, 270-292, 307-329, 336-355, 365-387, 400-422 and 432-449 216595015619 PS00216 Sugar transport proteins signature 1. 216595015620 Protein of unknown function, DUF393; Region: DUF393; cl01136 216595015622 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 216595015624 1 probable transmembrane helix predicted for PFLU3386 by TMHMM2.0 at aa 22-44 216595015625 PS00070 Aldehyde dehydrogenases cysteine active site. 216595015626 PS00070 Aldehyde dehydrogenases cysteine active site. 216595015627 PS00070 Aldehyde dehydrogenases cysteine active site. 216595015628 PS00070 Aldehyde dehydrogenases cysteine active site. 216595015629 PS00070 Aldehyde dehydrogenases cysteine active site. 216595015630 1 probable transmembrane helix predicted for PFLU3387 by TMHMM2.0 at aa 10-29 216595015631 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 216595015632 A49-like RNA polymerase I associated factor; Region: RNA_pol_I_A49; pfam06870 216595015633 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595015634 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595015635 2 probable transmembrane helices predicted for PFLU3388 by TMHMM2.0 at aa 30-52 and 216-238 216595015637 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 216595015638 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 216595015640 PS00221 MIP family signature. 216595015641 Ferritin-like; Region: Ferritin-like; pfam12902 216595015642 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 216595015644 PS00190 Cytochrome c family heme-binding site signature. 216595015645 Protein of unknown function (DUF1203); Region: DUF1203; pfam06718 216595015646 5 probable transmembrane helices predicted for PFLU3398 by TMHMM2.0 at aa 13-32, 37-59, 66-85, 90-112 and 119-141 216595015647 Beta-lactamase; Region: Beta-lactamase; cl01009 216595015649 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 216595015650 dimer interface [polypeptide binding]; other site 216595015652 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 216595015653 active site 216595015654 catalytic triad [active] 216595015655 oxyanion hole [active] 216595015657 PS00626 Regulator of chromosome condensation (RCC1) signature 2. 216595015658 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595015659 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 216595015660 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 216595015661 dimer interface [polypeptide binding]; other site 216595015662 active site 216595015663 catalytic residue [active] 216595015665 PS00666 Dihydrodipicolinate synthetase signature 2. 216595015666 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 216595015667 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 216595015668 dimer interface [polypeptide binding]; other site 216595015669 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595015670 catalytic residue [active] 216595015671 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as...; Region: CBS_pair_PALP_assoc2; cd04609 216595015673 PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. 216595015675 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 216595015676 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 216595015677 homodimer interface [polypeptide binding]; other site 216595015678 substrate-cofactor binding pocket; other site 216595015679 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595015680 catalytic residue [active] 216595015682 PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. 216595015683 TIGR03549 family protein; Region: TIGR03549 216595015684 OsmC-like protein; Region: OsmC; cl00767 216595015685 YcaO-like family; Region: YcaO; cl09146 216595015688 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216595015689 PAS fold; Region: PAS_3; pfam08447 216595015690 putative active site [active] 216595015691 heme pocket [chemical binding]; other site 216595015692 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595015693 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595015695 1 probable transmembrane helix predicted for PFLU3409 by TMHMM2.0 at aa 167-189 216595015697 PS00139 Eukaryotic thiol (cysteine) proteases cysteine active site. 216595015698 tartronate semialdehyde reductase; Provisional; Region: PRK15059 216595015699 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 216595015701 4 probable transmembrane helices predicted for PFLU3414 by TMHMM2.0 at aa 7-29, 39-61, 109-131 and 141-163 216595015702 Isochorismatase family; Region: Isochorismatase; pfam00857 216595015703 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 216595015704 catalytic triad [active] 216595015705 conserved cis-peptide bond; other site 216595015707 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 216595015708 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 216595015709 putative C-terminal domain interface [polypeptide binding]; other site 216595015710 putative GSH binding site (G-site) [chemical binding]; other site 216595015711 putative dimer interface [polypeptide binding]; other site 216595015712 C-terminal, alpha helical domain of GTT2-like Glutathione S-transferases; Region: GST_C_GTT2_like; cd03182 216595015713 putative N-terminal domain interface [polypeptide binding]; other site 216595015714 putative dimer interface [polypeptide binding]; other site 216595015715 putative substrate binding pocket (H-site) [chemical binding]; other site 216595015718 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216595015719 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216595015721 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 216595015723 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 216595015724 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 216595015725 Walker A/P-loop; other site 216595015726 ATP binding site [chemical binding]; other site 216595015727 Q-loop/lid; other site 216595015728 ABC transporter signature motif; other site 216595015729 Walker B; other site 216595015730 D-loop; other site 216595015731 H-loop/switch region; other site 216595015733 PS00017 ATP/GTP-binding site motif A (P-loop). 216595015734 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 216595015735 TM-ABC transporter signature motif; other site 216595015736 8 probable transmembrane helices predicted for PFLU3421 by TMHMM2.0 at aa 5-27, 32-54, 59-78, 91-113, 141-158, 188-210, 225-247 and 254-276 216595015738 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 216595015739 TM-ABC transporter signature motif; other site 216595015740 10 probable transmembrane helices predicted for PFLU3422 by TMHMM2.0 at aa 27-44, 48-70, 77-96, 101-123, 130-149, 182-200, 230-252, 267-285, 287-309 and 319-341 216595015742 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 216595015743 putative ligand binding site [chemical binding]; other site 216595015744 PS00037 Myb DNA-binding domain repeat signature 1. 216595015745 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain...; Region: Rieske_NirD; cd03529 216595015746 nitrite reductase subunit NirD; Provisional; Region: PRK14989 216595015747 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 216595015748 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 216595015750 PS00365 Nitrite and sulfite reductases iron-sulfur/siroheme-binding site. 216595015753 PS00022 EGF-like domain signature 1. 216595015757 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_Nitrate-R-NapA-like; cd02754 216595015758 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 216595015759 [4Fe-4S] binding site [ion binding]; other site 216595015760 molybdopterin cofactor binding site; other site 216595015761 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 216595015762 molybdopterin cofactor binding site; other site 216595015763 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 216595015764 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 216595015765 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 216595015766 FAD binding pocket [chemical binding]; other site 216595015767 FAD binding motif [chemical binding]; other site 216595015768 catalytic residues [active] 216595015769 NAD binding pocket [chemical binding]; other site 216595015770 phosphate binding motif [ion binding]; other site 216595015771 beta-alpha-beta structure motif; other site 216595015773 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 216595015779 Cache domain; Region: Cache_1; pfam02743 216595015780 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595015781 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595015782 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595015783 2 probable transmembrane helices predicted for PFLU3427 by TMHMM2.0 at aa 7-29 and 290-312 216595015784 PS00017 ATP/GTP-binding site motif A (P-loop). 216595015788 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 216595015789 active site 216595015790 NTP binding site [chemical binding]; other site 216595015791 metal binding triad [ion binding]; metal-binding site 216595015793 Predicted kinase [General function prediction only]; Region: COG0645 216595015794 PS00017 ATP/GTP-binding site motif A (P-loop). 216595015795 UV-endonuclease UvdE; Region: UvdE; cl10036 216595015797 4 probable transmembrane helices predicted for PFLU3431 by TMHMM2.0 at aa 50-72, 87-109, 121-140 and 150-172 216595015798 Membrane bound L-sorbosone dehydrogenase; Region: SNDH; pfam12303 216595015799 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 216595015800 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595015801 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595015802 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595015803 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595015804 dimerization interface [polypeptide binding]; other site 216595015807 PS00044 Bacterial regulatory proteins, lysR family signature. 216595015808 10 probable transmembrane helices predicted for PFLU3434 by TMHMM2.0 at aa 5-27, 37-56, 69-91, 96-115, 122-144, 154-174, 187-209, 229-251, 258-280 and 285-307 216595015809 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595015811 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595015812 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216595015813 Coenzyme A binding pocket [chemical binding]; other site 216595015816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595015817 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216595015818 putative substrate translocation pore; other site 216595015820 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 216595015822 proline/glycine betaine transporter; Provisional; Region: PRK10642 216595015823 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595015824 putative substrate translocation pore; other site 216595015825 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 216595015827 12 probable transmembrane helices predicted for PFLU3438 by TMHMM2.0 at aa 48-70, 85-107, 116-138, 142-161, 182-204, 217-239, 278-300, 315-337, 344-364, 369-391, 404-426 and 436-455 216595015828 PS00216 Sugar transport proteins signature 1. 216595015830 GAF domain; Region: GAF; cl00853 216595015832 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 216595015833 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216595015835 PS00041 Bacterial regulatory proteins, araC family signature. 216595015837 PS00041 Bacterial regulatory proteins, araC family signature. 216595015839 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 216595015840 1 probable transmembrane helix predicted for PFLU3441 by TMHMM2.0 at aa 13-30 216595015841 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 216595015842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595015843 putative substrate translocation pore; other site 216595015844 12 probable transmembrane helices predicted for PFLU3442 by TMHMM2.0 at aa 9-28, 48-70, 77-96, 101-123, 136-158, 163-185, 208-230, 240-262, 269-288, 298-320, 332-354 and 359-381 216595015846 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595015847 active site 216595015848 CHASE4 domain; Region: CHASE4; cl01308 216595015849 PAS domain S-box; Region: sensory_box; TIGR00229 216595015850 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 216595015851 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216595015852 metal binding site [ion binding]; metal-binding site 216595015853 active site 216595015854 I-site; other site 216595015855 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216595015856 2 probable transmembrane helices predicted for PFLU3444 by TMHMM2.0 at aa 25-47 and 261-283 216595015861 Cupin domain; Region: Cupin_2; cl09118 216595015862 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216595015863 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595015865 PS00041 Bacterial regulatory proteins, araC family signature. 216595015868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595015869 putative substrate translocation pore; other site 216595015871 10 probable transmembrane helices predicted for PFLU3446 by TMHMM2.0 at aa 72-94, 109-131, 171-193, 198-220, 241-263, 283-305, 312-331, 335-357, 370-392 and 397-419 216595015872 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595015873 dimer interface [polypeptide binding]; other site 216595015874 phosphorylation site [posttranslational modification] 216595015875 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595015876 ATP binding site [chemical binding]; other site 216595015877 Mg2+ binding site [ion binding]; other site 216595015878 G-X-G motif; other site 216595015881 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216595015882 metal binding site [ion binding]; metal-binding site 216595015883 active site 216595015884 I-site; other site 216595015885 7 probable transmembrane helices predicted for PFLU3448 by TMHMM2.0 at aa 5-27, 34-56, 61-83, 90-107, 117-139, 152-174 and 184-206 216595015887 MAPEG family; Region: MAPEG; cl09190 216595015889 PS00294 Prenyl group binding site (CAAX box). 216595015890 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216595015891 non-specific DNA binding site [nucleotide binding]; other site 216595015892 salt bridge; other site 216595015893 sequence-specific DNA binding site [nucleotide binding]; other site 216595015895 amidase; Validated; Region: PRK06565 216595015896 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 216595015898 PS00017 ATP/GTP-binding site motif A (P-loop). 216595015899 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 216595015901 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 216595015902 homotrimer interaction site [polypeptide binding]; other site 216595015903 putative active site [active] 216595015905 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 216595015907 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 216595015908 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 216595015909 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595015910 DNA-binding site [nucleotide binding]; DNA binding site 216595015911 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216595015912 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595015913 homodimer interface [polypeptide binding]; other site 216595015914 catalytic residue [active] 216595015917 10 probable transmembrane helices predicted for PFLU3461 by TMHMM2.0 at aa 17-39, 43-65, 78-100, 105-124, 131-150, 160-177, 184-206, 216-238, 245-267 and 272-291 216595015920 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595015921 YceI-like domain; Region: YceI; cl01001 216595015923 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 216595015924 CoenzymeA binding site [chemical binding]; other site 216595015925 subunit interaction site [polypeptide binding]; other site 216595015926 PHB binding site; other site 216595015927 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 216595015928 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595015929 1 probable transmembrane helix predicted for PFLU3464 by TMHMM2.0 at aa 34-56 216595015931 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 216595015932 PS00190 Cytochrome c family heme-binding site signature. 216595015933 Class II transport system: TRAP 216595015934 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 216595015935 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595015936 The C-terminal substrate-domain of LysR-type transcriptional regulators for beta-lactamase genes, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_beta_lactamase; cd08484 216595015937 putative dimerization interface [polypeptide binding]; other site 216595015938 putative substrate binding pocket [chemical binding]; other site 216595015941 PS00044 Bacterial regulatory proteins, lysR family signature. 216595015942 Beta-lactamase; Region: Beta-lactamase; cl01009 216595015944 PS00336 Beta-lactamase class-C active site. 216595015945 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216595015946 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 216595015947 DctM-like transporters; Region: DctM; pfam06808 216595015949 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 216595015951 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 216595015953 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 216595015955 CoA-transferase family III; Region: CoA_transf_3; cl00778 216595015957 PS00017 ATP/GTP-binding site motif A (P-loop). 216595015958 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 216595015960 PS00017 ATP/GTP-binding site motif A (P-loop). 216595015961 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216595015962 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216595015963 active site 216595015965 PS00073 Acyl-CoA dehydrogenases signature 2. 216595015966 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595015969 Uncharacterized conserved protein [Function unknown]; Region: COG3777 216595015970 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 216595015971 active site 2 [active] 216595015972 active site 1 [active] 216595015973 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595015974 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595015975 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 216595015976 putative dimerization interface [polypeptide binding]; other site 216595015978 PS00044 Bacterial regulatory proteins, lysR family signature. 216595015980 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595015981 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 216595015982 Walker A motif; other site 216595015983 ATP binding site [chemical binding]; other site 216595015984 Walker B motif; other site 216595015985 arginine finger; other site 216595015987 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 216595015989 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595015990 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 216595015991 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595015992 ATP binding site [chemical binding]; other site 216595015993 Mg2+ binding site [ion binding]; other site 216595015994 G-X-G motif; other site 216595015998 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 216595015999 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595016000 active site 216595016001 phosphorylation site [posttranslational modification] 216595016002 intermolecular recognition site; other site 216595016003 dimerization interface [polypeptide binding]; other site 216595016004 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 216595016005 DNA binding site [nucleotide binding] 216595016008 H+ Antiporter protein; Region: 2A0121; TIGR00900 216595016009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595016010 putative substrate translocation pore; other site 216595016012 10 probable transmembrane helices predicted for PFLU3485 by TMHMM2.0 at aa 21-43, 53-72, 79-101, 157-174, 219-241, 251-270, 275-297, 301-323, 344-366 and 370-392 216595016013 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 216595016014 active site 216595016015 dinuclear metal binding site [ion binding]; other site 216595016016 dimerization interface [polypeptide binding]; other site 216595016018 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 216595016019 universal stress protein UspE; Provisional; Region: PRK11175 216595016020 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216595016021 Ligand Binding Site [chemical binding]; other site 216595016024 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 216595016026 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 216595016027 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change...; Region: AcnB_Swivel; cd01576 216595016028 substrate binding site [chemical binding]; other site 216595016029 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 216595016030 substrate binding site [chemical binding]; other site 216595016031 ligand binding site [chemical binding]; other site 216595016034 PS00450 Aconitase family signature 1. 216595016035 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 216595016036 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 216595016038 Isochorismatase family; Region: Isochorismatase; pfam00857 216595016039 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 216595016040 catalytic triad [active] 216595016041 conserved cis-peptide bond; other site 216595016043 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 216595016044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595016047 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 216595016048 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 216595016049 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: ACAD10_11_like; cd05154 216595016050 putative active site [active] 216595016051 putative substrate binding site [chemical binding]; other site 216595016052 ATP binding site [chemical binding]; other site 216595016054 PS00109 Tyrosine protein kinases specific active-site signature. 216595016055 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216595016056 classical (c) SDRs; Region: SDR_c; cd05233 216595016057 NAD(P) binding site [chemical binding]; other site 216595016058 active site 216595016060 PS00061 Short-chain dehydrogenases/reductases family signature. 216595016061 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 216595016063 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 216595016064 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595016065 DNA-binding site [nucleotide binding]; DNA binding site 216595016066 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216595016067 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595016068 homodimer interface [polypeptide binding]; other site 216595016069 catalytic residue [active] 216595016072 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 216595016074 Cupin domain; Region: Cupin_2; cl09118 216595016076 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 216595016078 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 216595016080 8 probable transmembrane helices predicted for PFLU3500 by TMHMM2.0 at aa 9-28, 48-65, 78-100, 154-176, 189-211, 226-248, 305-327 and 352-374 216595016081 PS00079 Multicopper oxidases signature 1. 216595016082 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216595016083 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595016084 DNA-binding site [nucleotide binding]; DNA binding site 216595016085 FCD domain; Region: FCD; cl11656 216595016087 PS00043 Bacterial regulatory proteins, gntR family signature. 216595016089 Transcriptional regulators [Transcription]; Region: GntR; COG1802 216595016090 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595016091 DNA-binding site [nucleotide binding]; DNA binding site 216595016092 FCD domain; Region: FCD; cl11656 216595016095 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 216595016097 MoxR-like ATPases [General function prediction only]; Region: COG0714 216595016098 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595016099 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595016101 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 216595016102 Protein of unknown function DUF58; Region: DUF58; pfam01882 216595016104 1 probable transmembrane helix predicted for PFLU3508 by TMHMM2.0 at aa 22-41 216595016105 PS00340 Growth factor and cytokines receptors family signature 2. 216595016106 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-...; Region: vWA_BatA_type; cd01467 216595016107 metal ion-dependent adhesion site (MIDAS); other site 216595016109 1 probable transmembrane helix predicted for PFLU3509 by TMHMM2.0 at aa 301-320 216595016110 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 216595016111 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 216595016112 TPR motif; other site 216595016113 binding surface 216595016114 2 probable transmembrane helices predicted for PFLU3510 by TMHMM2.0 at aa 10-29 and 62-81 216595016116 1 probable transmembrane helix predicted for PFLU3511 by TMHMM2.0 at aa 409-431 216595016117 exonuclease subunit SbcD; Provisional; Region: PRK10966 216595016118 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 216595016119 active site 216595016120 metal binding site [ion binding]; metal-binding site 216595016121 DNA binding site [nucleotide binding] 216595016122 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 216595016124 exonuclease subunit SbcC; Provisional; Region: PRK10246 216595016125 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595016126 Walker A/P-loop; other site 216595016127 ATP binding site [chemical binding]; other site 216595016128 Q-loop/lid; other site 216595016129 exonuclease subunit SbcC; Provisional; Region: PRK10246 216595016130 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595016131 ABC transporter signature motif; other site 216595016132 Walker B; other site 216595016133 D-loop; other site 216595016134 H-loop/switch region; other site 216595016136 PS00017 ATP/GTP-binding site motif A (P-loop). 216595016137 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 216595016138 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 216595016139 C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196 216595016140 putative N-terminal domain interface [polypeptide binding]; other site 216595016141 putative dimer interface [polypeptide binding]; other site 216595016142 putative substrate binding pocket (H-site) [chemical binding]; other site 216595016145 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 216595016146 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 216595016147 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 216595016148 Ycf48-like protein; Provisional; Region: PRK13684 216595016155 1 probable transmembrane helix predicted for PFLU3522 by TMHMM2.0 at aa 24-46 216595016156 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 216595016157 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595016158 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 216595016162 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 216595016163 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595016164 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595016166 PS00455 Putative AMP-binding domain signature. 216595016167 PS00044 Bacterial regulatory proteins, lysR family signature. 216595016168 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 216595016169 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 216595016170 dimer interface [polypeptide binding]; other site 216595016171 active site 216595016174 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 216595016175 active site 2 [active] 216595016176 active site 1 [active] 216595016178 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 216595016179 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 216595016180 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595016181 NAD(P) binding site [chemical binding]; other site 216595016182 active site 216595016184 PS00061 Short-chain dehydrogenases/reductases family signature. 216595016185 acyl-CoA dehydrogenase; Reviewed; Region: PRK13026 216595016186 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216595016187 active site 216595016188 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 216595016192 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 216595016193 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl09488 216595016195 PS00037 Myb DNA-binding domain repeat signature 1. 216595016196 1 probable transmembrane helix predicted for PFLU3530 by TMHMM2.0 at aa 7-29 216595016197 1 probable transmembrane helix predicted for PFLU3531 by TMHMM2.0 at aa 7-29 216595016198 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 216595016199 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl09488 216595016201 1 probable transmembrane helix predicted for PFLU3532 by TMHMM2.0 at aa 38-60 216595016202 1 probable transmembrane helix predicted for PFLU3533 by TMHMM2.0 at aa 7-29 216595016203 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 216595016204 Fatty acid desaturase; Region: FA_desaturase; pfam00487 216595016205 Di-iron ligands [ion binding]; other site 216595016207 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 216595016208 low G+C content region (38.07%) 216595016209 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216595016211 1 probable transmembrane helix predicted for PFLU3536 by TMHMM2.0 at aa 43-65 216595016212 low G+C content region (36.6%) 216595016213 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 216595016216 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595016217 NAD(P) binding site [chemical binding]; other site 216595016218 short chain dehydrogenase; Provisional; Region: PRK05650 216595016219 active site 216595016221 PS00061 Short-chain dehydrogenases/reductases family signature. 216595016222 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 216595016223 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 216595016224 1 probable transmembrane helix predicted for PFLU3539 by TMHMM2.0 at aa 187-209 216595016225 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 216595016226 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216595016229 Catalytic domain of Protein Kinases; Region: PKc; cd00180 216595016230 active site 216595016231 ATP binding site [chemical binding]; other site 216595016232 substrate binding site [chemical binding]; other site 216595016233 activation loop (A-loop); other site 216595016235 PS00108 Serine/Threonine protein kinases active-site signature. 216595016236 PS00107 Protein kinases ATP-binding region signature. 216595016237 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 216595016238 Protein phosphatase 2C; Region: PP2C; pfam00481 216595016239 Active site [active] 216595016241 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 216595016242 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 216595016243 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 216595016245 PS00017 ATP/GTP-binding site motif A (P-loop). 216595016246 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 216595016247 1 probable transmembrane helix predicted for PFLU3545 by TMHMM2.0 at aa 204-226 216595016248 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 216595016250 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 216595016251 Protein of unknown function (DUF877); Region: DUF877; pfam05943 216595016253 Protein of unknown function (DUF770); Region: DUF770; cl01402 216595016255 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 216595016256 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 216595016257 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 216595016259 Protein of unknown function (DUF796); Region: DUF796; cl01226 216595016261 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 216595016262 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216595016263 active site 216595016264 catalytic tetrad [active] 216595016266 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 216595016268 Domain of unknown function (DUF477); Region: DUF477; cl01535 216595016270 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216595016272 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 216595016273 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 216595016274 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595016275 dimer interface [polypeptide binding]; other site 216595016276 phosphorylation site [posttranslational modification] 216595016277 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595016278 ATP binding site [chemical binding]; other site 216595016279 Mg2+ binding site [ion binding]; other site 216595016280 G-X-G motif; other site 216595016284 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 216595016285 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 216595016286 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 216595016289 Predicted kinase [General function prediction only]; Region: COG0645 216595016290 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595016292 PS00017 ATP/GTP-binding site motif A (P-loop). 216595016293 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 216595016294 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 216595016296 Creatinine amidohydrolase; Region: Creatininase; cl00618 216595016298 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595016299 probable transmembrane helices predicted for PFLU3562 by TMHMM2.0 at aa 3-25 216595016300 glutathione S-transferase; Provisional; Region: PRK15113 216595016301 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 216595016302 C-terminal domain interface [polypeptide binding]; other site 216595016303 GSH binding site (G-site) [chemical binding]; other site 216595016304 dimer interface [polypeptide binding]; other site 216595016305 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 216595016306 putative dimer interface [polypeptide binding]; other site 216595016307 N-terminal domain interface [polypeptide binding]; other site 216595016308 putative substrate binding pocket (H-site) [chemical binding]; other site 216595016309 PS00092 N-6 Adenine-specific DNA methylases signature. 216595016311 Bacterial protein of unknown function (DUF924); Region: DUF924; cl01561 216595016313 Secretin and TonB N terminus short domain; Region: STN; cl06624 216595016314 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 216595016315 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216595016316 N-terminal plug; other site 216595016317 ligand-binding site [chemical binding]; other site 216595016319 PS01156 TonB-dependent receptor proteins signature 2. 216595016322 fec operon regulator FecR; Reviewed; Region: PRK09774 216595016323 FecR protein; Region: FecR; pfam04773 216595016325 RNA polymerase sigma factor; Provisional; Region: PRK12528 216595016326 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216595016327 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 216595016328 DNA binding residues [nucleotide binding] 216595016331 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 216595016332 9 probable transmembrane helices predicted for PFLU3569 by TMHMM2.0 at aa 61-83, 95-117, 123-145, 150-169, 202-219, 231-253, 276-298, 305-327 and 351-373 216595016333 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 216595016334 N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_N_terminal_like; cd03312 216595016335 THF binding site; other site 216595016336 C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311 216595016337 substrate binding site [chemical binding]; other site 216595016338 THF binding site; other site 216595016339 zinc-binding site [ion binding]; other site 216595016342 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 216595016343 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216595016344 metal binding site [ion binding]; metal-binding site 216595016345 active site 216595016346 I-site; other site 216595016347 2 probable transmembrane helices predicted for PFLU3571 by TMHMM2.0 at aa 10-32 and 286-308 216595016350 outer membrane porin, OprD family; Region: OprD; pfam03573 216595016352 1 probable transmembrane helix predicted for PFLU3572 by TMHMM2.0 at aa 12-34 216595016353 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 216595016354 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 216595016355 active site 216595016356 metal binding site [ion binding]; metal-binding site 216595016357 hexamer interface [polypeptide binding]; other site 216595016359 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 216595016360 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595016361 Walker A/P-loop; other site 216595016362 ATP binding site [chemical binding]; other site 216595016363 Q-loop/lid; other site 216595016364 ABC transporter signature motif; other site 216595016365 Walker B; other site 216595016366 D-loop; other site 216595016367 H-loop/switch region; other site 216595016368 TOBE domain; Region: TOBE_2; cl01440 216595016371 PS00211 ABC transporters family signature. 216595016372 PS00017 ATP/GTP-binding site motif A (P-loop). 216595016373 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 216595016374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595016375 dimer interface [polypeptide binding]; other site 216595016376 conserved gate region; other site 216595016377 putative PBP binding loops; other site 216595016378 ABC-ATPase subunit interface; other site 216595016380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595016381 dimer interface [polypeptide binding]; other site 216595016382 conserved gate region; other site 216595016383 putative PBP binding loops; other site 216595016384 ABC-ATPase subunit interface; other site 216595016386 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 216595016387 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595016388 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216595016389 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216595016390 DNA binding site [nucleotide binding] 216595016391 Ligand-binding domain of putative DNA transcription repressors highly similar to that of the repressor specific for gluconate (GntR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_2; cd06282 216595016392 putative ligand binding site [chemical binding]; other site 216595016393 putative dimerization interface [polypeptide binding]; other site 216595016396 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 216595016397 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 216595016398 dimer interface [polypeptide binding]; other site 216595016399 active site 216595016400 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 216595016401 catalytic residues [active] 216595016402 substrate binding site [chemical binding]; other site 216595016403 PS00017 ATP/GTP-binding site motif A (P-loop). 216595016405 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 216595016406 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595016407 NAD(P) binding pocket [chemical binding]; other site 216595016409 PS00017 ATP/GTP-binding site motif A (P-loop). 216595016410 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595016411 Transcriptional regulator [Transcription]; Region: IclR; COG1414 216595016412 Bacterial transcriptional regulator; Region: IclR; pfam01614 216595016415 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595016416 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 216595016417 substrate binding pocket [chemical binding]; other site 216595016418 membrane-bound complex binding site; other site 216595016419 hinge residues; other site 216595016421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595016422 dimer interface [polypeptide binding]; other site 216595016423 conserved gate region; other site 216595016424 putative PBP binding loops; other site 216595016425 ABC-ATPase subunit interface; other site 216595016427 5 probable transmembrane helices predicted for PFLU3583 by TMHMM2.0 at aa 23-45, 58-80, 85-104, 138-157 and 187-209 216595016428 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595016429 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 216595016430 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 216595016431 Walker A/P-loop; other site 216595016432 ATP binding site [chemical binding]; other site 216595016433 Q-loop/lid; other site 216595016434 ABC transporter signature motif; other site 216595016435 Walker B; other site 216595016436 D-loop; other site 216595016437 H-loop/switch region; other site 216595016439 PS00017 ATP/GTP-binding site motif A (P-loop). 216595016440 PS00211 ABC transporters family signature. 216595016441 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 216595016442 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 216595016443 PS00043 Bacterial regulatory proteins, gntR family signature. 216595016445 Glutaminase; Region: Glutaminase; cl00907 216595016447 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216595016449 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 216595016450 B1 nucleotide binding pocket [chemical binding]; other site 216595016451 B2 nucleotide binding pocket [chemical binding]; other site 216595016452 CAS motifs; other site 216595016453 Active site [active] 216595016455 PS00531 Ribonuclease T2 family histidine active site 2. 216595016456 PS00530 Ribonuclease T2 family histidine active site 1. 216595016457 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 216595016458 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595016459 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 216595016461 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595016463 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667 216595016464 nudix motif; other site 216595016466 PS00893 mutT domain signature. 216595016467 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 216595016468 outer membrane porin, OprD family; Region: OprD; pfam03573 216595016470 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 216595016471 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 216595016473 transketolase; Reviewed; Region: PRK05899 216595016474 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 216595016475 TPP-binding site [chemical binding]; other site 216595016476 dimer interface [polypeptide binding]; other site 216595016477 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 216595016478 PYR/PP interface [polypeptide binding]; other site 216595016479 dimer interface [polypeptide binding]; other site 216595016480 TPP binding site [chemical binding]; other site 216595016481 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 216595016483 PS00801 Transketolase signature 1. 216595016485 PS00802 Transketolase signature 2. 216595016487 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 216595016488 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 216595016489 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 216595016491 PS00211 ABC transporters family signature. 216595016492 PS00017 ATP/GTP-binding site motif A (P-loop). 216595016493 PS00211 ABC transporters family signature. 216595016494 PS00017 ATP/GTP-binding site motif A (P-loop). 216595016495 sensory histidine kinase AtoS; Provisional; Region: PRK11360 216595016496 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595016497 dimer interface [polypeptide binding]; other site 216595016498 phosphorylation site [posttranslational modification] 216595016499 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595016500 ATP binding site [chemical binding]; other site 216595016501 G-X-G motif; other site 216595016502 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 216595016503 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595016504 active site 216595016505 phosphorylation site [posttranslational modification] 216595016506 intermolecular recognition site; other site 216595016507 dimerization interface [polypeptide binding]; other site 216595016512 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 216595016513 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 216595016514 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 216595016515 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 216595016516 generic binding surface I; other site 216595016517 generic binding surface II; other site 216595016521 DNA Polymerase Y-family; Region: PolY_like; cd03468 216595016522 active site 216595016523 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 216595016524 DNA binding site [nucleotide binding] 216595016525 Cell division inhibitor SulA; Region: SulA; cl01880 216595016526 LexA repressor; Provisional; Region: PRK12423 216595016527 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595016528 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 216595016529 Catalytic site [active] 216595016532 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 216595016533 RHS Repeat; Region: RHS_repeat; cl11982 216595016534 RHS Repeat; Region: RHS_repeat; cl11982 216595016535 RHS protein; Region: RHS; pfam03527 216595016536 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 216595016537 Pertussis toxin, subunit 1; Region: Pertussis_S1; cl03779 216595016552 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 216595016553 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 216595016554 dimer interface [polypeptide binding]; other site 216595016555 ADP-ribose binding site [chemical binding]; other site 216595016556 active site 216595016557 nudix motif; other site 216595016558 metal binding site [ion binding]; metal-binding site 216595016560 PS00017 ATP/GTP-binding site motif A (P-loop). 216595016561 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 216595016562 classical (c) SDRs; Region: SDR_c; cd05233 216595016563 NAD(P) binding site [chemical binding]; other site 216595016564 active site 216595016566 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595016567 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 216595016568 1 probable transmembrane helix predicted for PFLU3610 by TMHMM2.0 at aa 13-35 216595016570 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 216595016571 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 216595016572 phosphate binding site [ion binding]; other site 216595016574 PS00557 FMN-dependent alpha-hydroxy acid dehydrogenases active site. 216595016575 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 216595016576 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595016577 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 216595016579 PS00894 Bacterial regulatory proteins, deoR family signature. 216595016581 PS00141 Eukaryotic and viral aspartyl proteases active site. 216595016582 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 216595016583 proposed catalytic triad [active] 216595016584 conserved cys residue [active] 216595016586 PS00017 ATP/GTP-binding site motif A (P-loop). 216595016587 cardiolipin synthetase; Reviewed; Region: PRK12452 216595016588 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl11605 216595016591 1 probable transmembrane helix predicted for PFLU3618 by TMHMM2.0 at aa 9-28 216595016592 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 216595016593 HemN C-terminal region; Region: HemN_C; pfam06969 216595016595 AZL_007950 family protein; Region: AZL_007950_fam; TIGR04061 216595016596 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 216595016597 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 216595016598 Cu(I) binding site [ion binding]; other site 216595016599 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595016601 Protein of unknown function (DUF461); Region: DUF461; cl01071 216595016603 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 216595016604 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216595016605 Coenzyme A binding pocket [chemical binding]; other site 216595016607 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 216595016608 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216595016609 Coenzyme A binding pocket [chemical binding]; other site 216595016611 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216595016612 Coenzyme A binding pocket [chemical binding]; other site 216595016614 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 216595016616 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 216595016617 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 216595016620 fec operon regulator FecR; Reviewed; Region: PRK09774 216595016621 FecR protein; Region: FecR; pfam04773 216595016623 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 216595016624 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216595016625 N-terminal plug; other site 216595016626 ligand-binding site [chemical binding]; other site 216595016630 PS01156 TonB-dependent receptor proteins signature 2. 216595016631 Cupin domain; Region: Cupin_2; cl09118 216595016632 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595016633 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216595016634 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595016636 PS00011 Vitamin K-dependent carboxylation domain. 216595016638 PS00041 Bacterial regulatory proteins, araC family signature. 216595016640 LysE type translocator; Region: LysE; cl00565 216595016642 hydrolase, alpha/beta fold family protein; Region: PLN02824 216595016643 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216595016645 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 216595016646 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl10040 216595016648 1 probable transmembrane helix predicted for PFLU3637 by TMHMM2.0 at aa 15-37 216595016649 Predicted transcriptional regulator [Transcription]; Region: COG1959 216595016650 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595016651 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595016653 Mechanosensitive ion channel; Region: MS_channel; pfam00924 216595016654 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216595016655 ligand binding site [chemical binding]; other site 216595016656 flexible hinge region; other site 216595016659 Pirin-related protein [General function prediction only]; Region: COG1741 216595016660 Cupin domain; Region: Cupin_2; cl09118 216595016661 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 216595016664 osmolarity response regulator; Provisional; Region: ompR; PRK09468 216595016665 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595016666 active site 216595016667 phosphorylation site [posttranslational modification] 216595016668 intermolecular recognition site; other site 216595016669 dimerization interface [polypeptide binding]; other site 216595016670 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 216595016671 DNA binding site [nucleotide binding] 216595016674 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 216595016675 dimerization interface [polypeptide binding]; other site 216595016676 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 216595016677 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595016678 ATP binding site [chemical binding]; other site 216595016679 Mg2+ binding site [ion binding]; other site 216595016680 G-X-G motif; other site 216595016681 1 probable transmembrane helix predicted for PFLU3642 by TMHMM2.0 at aa 13-35 216595016685 enterobactin receptor protein; Provisional; Region: PRK13483 216595016686 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216595016687 N-terminal plug; other site 216595016688 ligand-binding site [chemical binding]; other site 216595016690 PS01156 TonB-dependent receptor proteins signature 2. 216595016692 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216595016693 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 216595016694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595016695 putative substrate translocation pore; other site 216595016697 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 216595016699 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 216595016701 12 probable transmembrane helices predicted for PFLU3646 by TMHMM2.0 at aa 13-32, 341-358, 360-382, 392-414, 427-449, 464-486, 527-546, 858-877, 884-906, 910-932, 962-984 and 989-1011 216595016702 low G+C content region (41.32%) 216595016703 hypothetical protein; Provisional; Region: PRK07338 216595016704 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 216595016705 metal binding site [ion binding]; metal-binding site 216595016706 dimer interface [polypeptide binding]; other site 216595016709 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 216595016710 1 probable transmembrane helix predicted for PFLU3649 by TMHMM2.0 at aa 13-35 216595016711 MASE2 domain; Region: MASE2; pfam05230 216595016712 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216595016713 metal binding site [ion binding]; metal-binding site 216595016714 active site 216595016715 I-site; other site 216595016718 LysE type translocator; Region: LysE; cl00565 216595016720 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595016721 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 216595016722 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595016723 DNA-binding site [nucleotide binding]; DNA binding site 216595016724 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216595016725 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595016726 homodimer interface [polypeptide binding]; other site 216595016727 catalytic residue [active] 216595016730 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595016731 osmolarity response regulator; Provisional; Region: ompR; PRK09468 216595016732 active site 216595016733 phosphorylation site [posttranslational modification] 216595016734 intermolecular recognition site; other site 216595016735 dimerization interface [polypeptide binding]; other site 216595016736 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 216595016737 DNA binding site [nucleotide binding] 216595016740 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 216595016741 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 216595016742 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595016743 ATP binding site [chemical binding]; other site 216595016744 Mg2+ binding site [ion binding]; other site 216595016745 G-X-G motif; other site 216595016746 2 probable transmembrane helices predicted for PFLU3654 by TMHMM2.0 at aa 15-37 and 157-179 216595016750 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 216595016751 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 216595016752 DNA binding site [nucleotide binding] 216595016754 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 216595016755 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 216595016756 DNA binding site [nucleotide binding] 216595016758 PFI-9 216595016759 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 216595016760 Bacterial sugar transferase; Region: Bac_transf; cl00939 216595016761 5 probable transmembrane helices predicted for PFLU3658 by TMHMM2.0 at aa 23-45, 55-74, 86-108, 118-140 and 290-309 216595016763 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 216595016765 SLBB-domain like (DUF1017); Region: DUF1017; pfam06251 216595016767 1 probable transmembrane helix predicted for PFLU3660 by TMHMM2.0 at aa 7-29 216595016768 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 216595016769 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 216595016770 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595016771 polysaccharide export protein Wza; Provisional; Region: PRK15078 216595016772 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 216595016774 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 216595016775 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 216595016776 Substrate binding site [chemical binding]; other site 216595016777 Cupin domain; Region: Cupin_2; cl09118 216595016780 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 216595016781 active site 216595016782 GDP-Mannose binding site [chemical binding]; other site 216595016783 dimer interface [polypeptide binding]; other site 216595016784 modified nudix motif 216595016785 metal binding site [ion binding]; metal-binding site 216595016787 putative glycosyl transferase; Provisional; Region: PRK10307 216595016788 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 216595016790 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 216595016791 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 216595016792 NADP binding site [chemical binding]; other site 216595016793 active site 216595016794 putative substrate binding site [chemical binding]; other site 216595016796 GDP-mannose 4,6-dehydratase; Region: gmd; TIGR01472 216595016797 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 216595016798 NADP-binding site; other site 216595016799 homotetramer interface [polypeptide binding]; other site 216595016800 substrate binding site [chemical binding]; other site 216595016801 homodimer interface [polypeptide binding]; other site 216595016802 active site 216595016804 PS00061 Short-chain dehydrogenases/reductases family signature. 216595016805 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 216595016806 putative metal binding site [ion binding]; other site 216595016808 putative acyl transferase; Provisional; Region: PRK10502 216595016809 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 216595016810 putative trimer interface [polypeptide binding]; other site 216595016811 putative active site [active] 216595016812 putative substrate binding site [chemical binding]; other site 216595016813 putative CoA binding site [chemical binding]; other site 216595016818 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216595016819 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 216595016820 putative ADP-binding pocket [chemical binding]; other site 216595016822 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 216595016824 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-...; Region: LbH_MAT_like; cd04647 216595016825 trimer interface [polypeptide binding]; other site 216595016826 active site 216595016827 substrate binding site [chemical binding]; other site 216595016828 CoA binding site [chemical binding]; other site 216595016829 PS00101 Hexapeptide-repeat containing-transferases signature. 216595016833 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 216595016834 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 216595016835 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595016836 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 216595016837 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595016841 tyrosine kinase; Provisional; Region: PRK11519 216595016842 Chain length determinant protein; Region: Wzz; cl01623 216595016843 Chain length determinant protein; Region: Wzz; cl01623 216595016844 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 216595016845 P loop; other site 216595016846 Nucleotide binding site [chemical binding]; other site 216595016847 DTAP/Switch II; other site 216595016848 Switch I; other site 216595016850 Low molecular weight phosphatase family; Region: LMWPc; cd00115 216595016851 Active site [active] 216595016853 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 216595016854 active site 216595016855 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 216595016856 dimer interface [polypeptide binding]; other site 216595016857 non-prolyl cis peptide bond; other site 216595016858 insertion regions; other site 216595016860 PS00012 Phosphopantetheine attachment site. 216595016861 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 216595016862 active site 216595016863 intersubunit interface [polypeptide binding]; other site 216595016864 Zn2+ binding site [ion binding]; other site 216595016866 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595016867 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595016868 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 216595016869 dimerization interface [polypeptide binding]; other site 216595016872 PS00044 Bacterial regulatory proteins, lysR family signature. 216595016873 low G+C content region (40.35%) 216595016874 Cysteine dioxygenase type I; Region: CDO_I; cl02350 216595016876 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 216595016877 active site residue [active] 216595016878 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative...; Region: 4RHOD_Repeat_2; cd01533 216595016879 active site residue [active] 216595016880 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 216595016881 active site residue [active] 216595016882 Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the...; Region: 4RHOD_Repeat_4; cd01535 216595016883 active site residue [active] 216595016885 PS00380 Rhodanese signature 1. 216595016886 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 216595016887 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595016888 substrate binding pocket [chemical binding]; other site 216595016889 membrane-bound complex binding site; other site 216595016890 hinge residues; other site 216595016892 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 216595016893 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 216595016894 active site 216595016895 non-prolyl cis peptide bond; other site 216595016896 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 216595016897 putative catalytic residues [active] 216595016899 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216595016900 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 216595016901 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 216595016904 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595016907 Gram-negative bacterial tonB protein; Region: TonB; cl10048 216595016909 1 probable transmembrane helix predicted for PFLU3694 by TMHMM2.0 at aa 21-43 216595016910 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 216595016912 1 probable transmembrane helix predicted for PFLU3695 by TMHMM2.0 at aa 17-39 216595016913 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 216595016914 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 216595016916 Phytase; Region: Phytase; pfam02333 216595016917 Phytase; Region: Phytase; pfam02333 216595016919 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 216595016920 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 216595016921 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216595016924 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216595016925 metal binding site [ion binding]; metal-binding site 216595016926 active site 216595016927 I-site; other site 216595016928 3 probable transmembrane helices predicted for PFLU3699 by TMHMM2.0 at aa 12-29, 39-61 and 68-86 216595016930 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 216595016931 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216595016933 LysR family transcriptional regulator; Provisional; Region: PRK14997 216595016934 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595016935 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 216595016936 putative effector binding pocket; other site 216595016937 dimerization interface [polypeptide binding]; other site 216595016940 PS00044 Bacterial regulatory proteins, lysR family signature. 216595016941 Isochorismatase family; Region: Isochorismatase; pfam00857 216595016942 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them...; Region: YcaC_related; cd01012 216595016943 catalytic triad [active] 216595016944 dimer interface [polypeptide binding]; other site 216595016945 conserved cis-peptide bond; other site 216595016947 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 216595016948 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 216595016949 active site 216595016951 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 216595016953 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595016954 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595016955 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 216595016956 putative substrate binding pocket [chemical binding]; other site 216595016957 putative dimerization interface [polypeptide binding]; other site 216595016961 PS00041 Bacterial regulatory proteins, araC family signature. 216595016963 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 216595016964 DNA binding site [nucleotide binding] 216595016965 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595016967 PS00017 ATP/GTP-binding site motif A (P-loop). 216595016968 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 216595016969 DNA binding site [nucleotide binding] 216595016970 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595016971 PS00017 ATP/GTP-binding site motif A (P-loop). 216595016973 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 216595016974 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 216595016975 conserved cys residue [active] 216595016976 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595016977 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595016981 Pirin-related protein [General function prediction only]; Region: COG1741 216595016982 Cupin domain; Region: Cupin_2; cl09118 216595016984 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 216595016985 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 216595016986 conserved cys residue [active] 216595016987 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595016988 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595016990 PS00041 Bacterial regulatory proteins, araC family signature. 216595016993 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 216595016994 active site 216595016995 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 216595016996 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 216595016997 Walker A/P-loop; other site 216595016998 ATP binding site [chemical binding]; other site 216595016999 Q-loop/lid; other site 216595017000 ABC transporter signature motif; other site 216595017001 Walker B; other site 216595017002 D-loop; other site 216595017003 H-loop/switch region; other site 216595017005 PS00211 ABC transporters family signature. 216595017006 PS00017 ATP/GTP-binding site motif A (P-loop). 216595017007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595017008 putative PBP binding loops; other site 216595017009 dimer interface [polypeptide binding]; other site 216595017010 ABC-ATPase subunit interface; other site 216595017012 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 216595017014 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 216595017015 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 216595017016 active site 216595017017 non-prolyl cis peptide bond; other site 216595017019 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 216595017020 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595017021 substrate binding pocket [chemical binding]; other site 216595017022 membrane-bound complex binding site; other site 216595017023 hinge residues; other site 216595017025 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 216595017026 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595017027 substrate binding pocket [chemical binding]; other site 216595017028 membrane-bound complex binding site; other site 216595017029 hinge residues; other site 216595017031 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 216595017032 bacterial glycerol kinase 2-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK2_bacteria; cd07791 216595017033 putative N- and C-terminal domain interface [polypeptide binding]; other site 216595017034 putative active site [active] 216595017035 putative MgATP binding site [chemical binding]; other site 216595017036 catalytic site [active] 216595017037 metal binding site [ion binding]; metal-binding site 216595017038 putative homotetramer interface [polypeptide binding]; other site 216595017039 putative homodimer interface [polypeptide binding]; other site 216595017040 putative glycerol binding site [chemical binding]; other site 216595017042 PS00445 FGGY family of carbohydrate kinases signature 2. 216595017044 PS00933 FGGY family of carbohydrate kinases signature 1. 216595017045 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 216595017046 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 216595017047 PYR/PP interface [polypeptide binding]; other site 216595017048 dimer interface [polypeptide binding]; other site 216595017049 TPP binding site [chemical binding]; other site 216595017050 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 216595017053 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 216595017054 TPP-binding site [chemical binding]; other site 216595017055 dimer interface [polypeptide binding]; other site 216595017057 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216595017058 TM-ABC transporter signature motif; other site 216595017059 8 probable transmembrane helices predicted for PFLU3726 by TMHMM2.0 at aa 29-51, 63-80, 84-101, 108-130, 176-198, 228-250, 265-295 and 302-324 216595017061 PS00027 'Homeobox' domain signature. 216595017062 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 216595017063 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 216595017064 ligand binding site [chemical binding]; other site 216595017066 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 216595017067 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 216595017068 Walker A/P-loop; other site 216595017069 ATP binding site [chemical binding]; other site 216595017070 Q-loop/lid; other site 216595017071 ABC transporter signature motif; other site 216595017072 Walker B; other site 216595017073 D-loop; other site 216595017074 H-loop/switch region; other site 216595017075 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 216595017077 PS00017 ATP/GTP-binding site motif A (P-loop). 216595017079 PS00211 ABC transporters family signature. 216595017080 short chain dehydrogenase; Provisional; Region: PRK06114 216595017081 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595017082 NAD(P) binding site [chemical binding]; other site 216595017083 active site 216595017085 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216595017086 PS00061 Short-chain dehydrogenases/reductases family signature. 216595017087 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216595017088 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 216595017089 NAD binding site [chemical binding]; other site 216595017090 homotetramer interface [polypeptide binding]; other site 216595017091 homodimer interface [polypeptide binding]; other site 216595017092 active site 216595017093 substrate binding site [chemical binding]; other site 216595017095 PS00061 Short-chain dehydrogenases/reductases family signature. 216595017096 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 216595017097 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 216595017099 transaldolase-like protein; Provisional; Region: PTZ00411 216595017100 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 216595017101 active site 216595017102 dimer interface [polypeptide binding]; other site 216595017103 catalytic residue [active] 216595017105 PS01054 Transaldolase signature 1. 216595017106 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cd00333 216595017107 amphipathic channel; other site 216595017108 Asn-Pro-Ala signature motifs; other site 216595017110 PS00221 MIP family signature. 216595017111 putative arabinose transporter; Provisional; Region: PRK03545 216595017112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595017113 putative substrate translocation pore; other site 216595017115 Membrane transport protein; Region: Mem_trans; cl09117 216595017116 PS00904 Protein prenyltransferases alpha subunit repeat signature. 216595017118 Cupin domain; Region: Cupin_2; cl09118 216595017119 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216595017120 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595017122 PS00041 Bacterial regulatory proteins, araC family signature. 216595017124 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216595017125 12 probable transmembrane helices predicted for PFLU3738 by TMHMM2.0 at aa 13-35, 45-67, 74-96, 101-123, 144-161, 166-188, 231-253, 263-282, 295-314, 318-340, 353-375 and 385-407 216595017127 PS00017 ATP/GTP-binding site motif A (P-loop). 216595017128 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 216595017129 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216595017131 Predicted small integral membrane protein (DUF2160); Region: DUF2160; cl02294 216595017132 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595017133 dimer interface [polypeptide binding]; other site 216595017134 conserved gate region; other site 216595017135 putative PBP binding loops; other site 216595017136 ABC-ATPase subunit interface; other site 216595017138 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595017139 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 216595017140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595017141 putative PBP binding loops; other site 216595017142 dimer interface [polypeptide binding]; other site 216595017143 ABC-ATPase subunit interface; other site 216595017145 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 216595017146 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 216595017147 Walker A/P-loop; other site 216595017148 ATP binding site [chemical binding]; other site 216595017149 Q-loop/lid; other site 216595017150 ABC transporter signature motif; other site 216595017151 Walker B; other site 216595017152 D-loop; other site 216595017153 H-loop/switch region; other site 216595017156 PS00017 ATP/GTP-binding site motif A (P-loop). 216595017157 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 216595017158 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 216595017159 Walker A/P-loop; other site 216595017160 ATP binding site [chemical binding]; other site 216595017161 Q-loop/lid; other site 216595017162 ABC transporter signature motif; other site 216595017163 Walker B; other site 216595017164 D-loop; other site 216595017165 H-loop/switch region; other site 216595017168 PS00017 ATP/GTP-binding site motif A (P-loop). 216595017169 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 216595017170 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595017171 Walker A motif; other site 216595017172 ATP binding site [chemical binding]; other site 216595017173 Walker B motif; other site 216595017174 arginine finger; other site 216595017175 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 216595017178 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 216595017179 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 216595017181 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 216595017182 FecR protein; Region: FecR; pfam04773 216595017184 1 probable transmembrane helix predicted for PFLU3748 by TMHMM2.0 at aa 80-102 216595017185 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216595017186 PS00173 Xylose isomerase signature 2. 216595017187 RNA polymerase sigma factor; Provisional; Region: PRK12528 216595017188 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216595017189 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 216595017190 DNA binding residues [nucleotide binding] 216595017194 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 216595017195 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 216595017196 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216595017197 ligand-binding site [chemical binding]; other site 216595017200 low G+C content region (40%) 216595017201 1 probable transmembrane helix predicted for PFLU3752 by TMHMM2.0 at aa 21-43 216595017202 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 216595017203 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216595017204 non-specific DNA binding site [nucleotide binding]; other site 216595017205 salt bridge; other site 216595017206 sequence-specific DNA binding site [nucleotide binding]; other site 216595017207 Cupin domain; Region: Cupin_2; cl09118 216595017212 PAS domain S-box; Region: sensory_box; TIGR00229 216595017213 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216595017214 putative active site [active] 216595017215 heme pocket [chemical binding]; other site 216595017216 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216595017217 metal binding site [ion binding]; metal-binding site 216595017218 active site 216595017219 I-site; other site 216595017222 low G+C content region (47.9%) 216595017223 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216595017224 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595017225 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 216595017227 PS00041 Bacterial regulatory proteins, araC family signature. 216595017230 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 216595017231 catalytic site [active] 216595017232 metal binding site [ion binding]; metal-binding site 216595017233 gcgggnnnncccgc 216595017234 YccA-like proteins; Region: YccA_like; cd10433 216595017236 7 probable transmembrane helices predicted for PFLU3767 by TMHMM2.0 at aa 22-44, 49-68, 75-97, 107-129, 136-158, 162-181 and 194-216 216595017237 PS01243 Uncharacterized protein family UPF0005 signature. 216595017238 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 216595017239 FAD binding domain; Region: FAD_binding_4; pfam01565 216595017240 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 216595017243 Low molecular weight phosphatase family; Region: LMWPc; cd00115 216595017244 Active site [active] 216595017246 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 216595017247 Ligand binding site [chemical binding]; other site 216595017248 oligomer interface [polypeptide binding]; other site 216595017250 Trm112p-like protein; Region: Trm112p; cl01066 216595017252 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 216595017253 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 216595017255 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 216595017257 1 probable transmembrane helix predicted for PFLU3773 by TMHMM2.0 at aa 13-35 216595017258 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 216595017259 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 216595017261 Competence protein; Region: Competence; cl00471 216595017262 Competence protein; Region: Competence; cl00471 216595017263 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 216595017266 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 216595017267 3 probable transmembrane helices predicted for PFLU3776 by TMHMM2.0 at aa 47-69, 82-104 and 137-159 216595017268 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 216595017269 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595017270 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595017271 dimer interface [polypeptide binding]; other site 216595017272 phosphorylation site [posttranslational modification] 216595017273 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595017274 ATP binding site [chemical binding]; other site 216595017275 Mg2+ binding site [ion binding]; other site 216595017276 G-X-G motif; other site 216595017277 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595017278 active site 216595017279 phosphorylation site [posttranslational modification] 216595017280 intermolecular recognition site; other site 216595017281 dimerization interface [polypeptide binding]; other site 216595017282 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 216595017283 2 probable transmembrane helices predicted for PFLU3777 by TMHMM2.0 at aa 10-32 and 169-191 216595017289 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 216595017290 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595017293 PS00017 ATP/GTP-binding site motif A (P-loop). 216595017294 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 216595017295 PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. 216595017296 PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 216595017297 META domain; Region: META; cl01245 216595017298 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595017300 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 216595017301 catalytic residues [active] 216595017303 PS00194 Thioredoxin family active site. 216595017304 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595017305 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 216595017306 catalytic residues [active] 216595017308 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 216595017310 Predicted membrane protein (DUF2069); Region: DUF2069; cl01299 216595017311 4 probable transmembrane helices predicted for PFLU3784 by TMHMM2.0 at aa 20-42, 52-74, 79-96 and 100-122 216595017312 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 216595017314 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 216595017315 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This...; Region: Alpha_ANH_like_II; cd01993 216595017316 Ligand Binding Site [chemical binding]; other site 216595017318 Yip1 domain; Region: Yip1; cl12048 216595017319 6 probable transmembrane helices predicted for PFLU3787 by TMHMM2.0 at aa 15-37, 63-85, 100-122, 135-154, 158-180 and 193-215 216595017321 SprT homologues; Region: SprT; cl01182 216595017322 SprT-like family; Region: SprT-like; pfam10263 216595017324 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 216595017325 CoA-transferase family III; Region: CoA_transf_3; cl00778 216595017327 DsrE/DsrF-like family; Region: DrsE; cl00672 216595017329 DsrE/DsrF-like family; Region: DrsE; cl00672 216595017331 DsrE/DsrF-like family; Region: DrsE; cl00672 216595017333 DsrC like protein; Region: DsrC; cl01101 216595017335 hypothetical protein; Validated; Region: PRK09071 216595017336 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 216595017337 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 216595017339 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 216595017340 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 216595017341 putative dimer interface [polypeptide binding]; other site 216595017342 N-terminal domain interface [polypeptide binding]; other site 216595017343 putative substrate binding pocket (H-site) [chemical binding]; other site 216595017345 siroheme synthase; Provisional; Region: cysG; PRK10637 216595017346 precorrin-2 dehydrogenase; Validated; Region: PRK06719 216595017347 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 216595017348 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 216595017350 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595017351 PS00840 Uroporphyrin-III C-methyltransferase signature 2. 216595017352 seryl-tRNA synthetase; Provisional; Region: PRK05431 216595017353 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 216595017354 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 216595017355 dimer interface [polypeptide binding]; other site 216595017356 active site 216595017357 motif 1; other site 216595017358 motif 2; other site 216595017359 motif 3; other site 216595017361 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 216595017363 CrcB-like protein; Region: CRCB; cl09114 216595017365 recombination factor protein RarA; Reviewed; Region: PRK13342 216595017366 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595017367 Walker A motif; other site 216595017368 ATP binding site [chemical binding]; other site 216595017369 Walker B motif; other site 216595017370 arginine finger; other site 216595017371 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 216595017373 PS00017 ATP/GTP-binding site motif A (P-loop). 216595017374 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 216595017375 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 216595017377 DNA translocase FtsK; Provisional; Region: PRK10263 216595017378 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595017379 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 216595017381 PS00017 ATP/GTP-binding site motif A (P-loop). 216595017382 Leucyl/phenylalanyl-tRNA protein transferase; Region: Leu_Phe_trans; cl01006 216595017384 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 216595017385 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 216595017386 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 216595017389 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 216595017390 rRNA binding site [nucleotide binding]; other site 216595017391 predicted 30S ribosome binding site; other site 216595017393 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 216595017394 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595017395 Walker A motif; other site 216595017396 ATP binding site [chemical binding]; other site 216595017397 Walker B motif; other site 216595017398 arginine finger; other site 216595017399 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595017400 Walker A motif; other site 216595017401 ATP binding site [chemical binding]; other site 216595017402 Walker B motif; other site 216595017403 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 216595017404 PS00024 Hemopexin domain signature. 216595017406 PS00871 Chaperonins clpA/B signature 2. 216595017407 PS00017 ATP/GTP-binding site motif A (P-loop). 216595017409 PS00870 Chaperonins clpA/B signature 1. 216595017410 PS00017 ATP/GTP-binding site motif A (P-loop). 216595017412 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 216595017414 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 216595017415 DNA-binding site [nucleotide binding]; DNA binding site 216595017416 RNA-binding motif; other site 216595017418 PS00352 'Cold-shock' DNA-binding domain signature. 216595017419 isocitrate dehydrogenase; Validated; Region: PRK07362 216595017420 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 216595017422 PS00470 Isocitrate and isopropylmalate dehydrogenases signature. 216595017423 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 216595017424 isocitrate dehydrogenase, NADP-dependent, monomeric type; Region: monomer_idh; TIGR00178 216595017427 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X...; Region: Nudix_Hydrolase_2; cd03675 216595017428 nudix motif; other site 216595017430 PS00893 mutT domain signature. 216595017431 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 216595017432 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 216595017434 PS00070 Aldehyde dehydrogenases cysteine active site. 216595017435 Protein of unknown function (DUF489); Region: DUF489; cl01097 216595017437 adenylosuccinate lyase; Provisional; Region: PRK09285 216595017438 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 216595017439 tetramer interface [polypeptide binding]; other site 216595017440 active site 216595017442 PS00163 Fumarate lyases signature. 216595017444 Uncharacterized conserved protein [Function unknown]; Region: COG2850 216595017446 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 216595017448 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 216595017449 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 216595017451 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 216595017452 tetramer interface [polypeptide binding]; other site 216595017453 active site 216595017454 Mg2+/Mn2+ binding site [ion binding]; other site 216595017456 PS00161 Isocitrate lyase signature. 216595017457 low G+C content region (44.58%) 216595017458 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 216595017459 3 probable transmembrane helices predicted for PFLU3818 by TMHMM2.0 at aa 40-62, 92-114 and 124-146 216595017461 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 216595017463 PS01150 Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. 216595017464 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl00539 216595017465 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 216595017466 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 216595017468 PS00535 Respiratory chain NADH dehydrogenase 49 Kd subunit signature. 216595017470 NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958 216595017471 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of...; Region: TRX_Fd_NuoE; cd03064 216595017472 putative dimer interface [polypeptide binding]; other site 216595017473 [2Fe-2S] cluster binding site [ion binding]; other site 216595017475 PS01099 Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. 216595017476 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 216595017477 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 216595017478 SLBB domain; Region: SLBB; pfam10531 216595017479 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 216595017481 PS00644 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. 216595017482 PS00645 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. 216595017483 PS00017 ATP/GTP-binding site motif A (P-loop). 216595017484 NADH dehydrogenase subunit G; Validated; Region: PRK08166 216595017485 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216595017486 catalytic loop [active] 216595017487 iron binding site [ion binding]; other site 216595017488 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 216595017489 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 216595017490 [4Fe-4S] binding site [ion binding]; other site 216595017491 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 216595017493 PS00641 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. 216595017494 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595017495 PS00642 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. 216595017496 PS00643 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. 216595017499 PS00490 Prokaryotic molybdopterin oxidoreductases signature 2. 216595017500 NADH dehydrogenase; Region: NADHdh; cl00469 216595017501 8 probable transmembrane helices predicted for PFLU3824 by TMHMM2.0 at aa 13-35, 81-103, 115-137, 152-174, 187-209, 239-261, 273-295 and 305-327 216595017503 PS00668 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. 216595017504 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 216595017505 4Fe-4S binding domain; Region: Fer4; cl02805 216595017506 4Fe-4S binding domain; Region: Fer4; cl02805 216595017508 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216595017510 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216595017511 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 216595017512 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 216595017513 5 probable transmembrane helices predicted for PFLU3826 by TMHMM2.0 at aa 5-22, 29-51, 56-78, 91-113 and 138-160 216595017515 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 216595017516 3 probable transmembrane helices predicted for PFLU3827 by TMHMM2.0 at aa 5-27, 32-54 and 64-86 216595017518 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 216595017519 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 216595017520 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 216595017521 17 probable transmembrane helices predicted for PFLU3828 by TMHMM2.0 at aa 4-21, 28-50, 86-108, 115-134, 138-160, 173-195, 215-237, 250-269, 279-301, 308-330, 334-356, 377-399, 414-436, 456-478, 498-517, 529-548 and 594-616 216595017524 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 216595017525 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 216595017526 13 probable transmembrane helices predicted for PFLU3829 by TMHMM2.0 at aa 2-20, 30-47, 82-104, 114-133, 140-162, 177-199, 223-245, 287-309, 316-333, 343-365, 378-400, 420-442 and 463-485 216595017528 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 216595017529 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 216595017530 14 probable transmembrane helices predicted for PFLU3830 by TMHMM2.0 at aa 29-51, 58-80, 95-117, 130-147, 151-173, 185-207, 227-249, 261-283, 293-315, 322-341, 351-373, 394-416, 431-453 and 474-493 216595017532 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 216595017533 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 216595017534 N-acetyltransferase; Region: Acetyltransf_2; cl00949 216595017536 Protein of unknown function (DUF3087); Region: DUF3087; pfam11286 216595017537 2 probable transmembrane helices predicted for PFLU3838 by TMHMM2.0 at aa 31-53 and 63-84 216595017539 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 216595017540 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595017541 putative substrate translocation pore; other site 216595017543 Predicted integral membrane protein (DUF2282); Region: DUF2282; cl02366 216595017544 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 216595017545 ggaaccnnnnnnnnnnnnnnnnccacnna 216595017546 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 216595017548 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 216595017549 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216595017550 tetrameric interface [polypeptide binding]; other site 216595017551 activator binding site; other site 216595017552 NADP binding site [chemical binding]; other site 216595017553 substrate binding site [chemical binding]; other site 216595017554 catalytic residues [active] 216595017556 PS00070 Aldehyde dehydrogenases cysteine active site. 216595017557 Predicted membrane protein [Function unknown]; Region: COG1289 216595017558 4 probable transmembrane helices predicted for PFLU3845 by TMHMM2.0 at aa 27-49, 97-119, 124-141 and 156-178 216595017559 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216595017560 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216595017562 low G+C conent region (50.14%) 216595017563 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 216595017564 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 216595017565 Walker A/P-loop; other site 216595017566 ATP binding site [chemical binding]; other site 216595017567 Q-loop/lid; other site 216595017568 ABC transporter signature motif; other site 216595017569 Walker B; other site 216595017570 D-loop; other site 216595017571 H-loop/switch region; other site 216595017573 PS00017 ATP/GTP-binding site motif A (P-loop). 216595017574 PS00211 ABC transporters family signature. 216595017575 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 216595017576 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 216595017577 FtsX-like permease family; Region: FtsX; pfam02687 216595017578 4 probable transmembrane helices predicted for PFLU3848 by TMHMM2.0 at aa 33-55, 279-301, 329-351 and 366-388 216595017580 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 216595017581 Outer membrane efflux protein; Region: OEP; pfam02321 216595017582 Outer membrane efflux protein; Region: OEP; pfam02321 216595017585 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 216595017586 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404 216595017587 1 probable transmembrane helix predicted for PFLU3850 by TMHMM2.0 at aa 7-24 216595017589 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 216595017590 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595017591 PS00215 Mitochondrial energy transfer proteins signature. 216595017593 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 216595017594 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 216595017595 Walker A/P-loop; other site 216595017596 ATP binding site [chemical binding]; other site 216595017597 Q-loop/lid; other site 216595017598 ABC transporter signature motif; other site 216595017599 Walker B; other site 216595017600 D-loop; other site 216595017601 H-loop/switch region; other site 216595017603 PS00017 ATP/GTP-binding site motif A (P-loop). 216595017604 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 216595017605 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 216595017606 putative ligand binding site [chemical binding]; other site 216595017607 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 216595017608 TM-ABC transporter signature motif; other site 216595017610 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 216595017611 TM-ABC transporter signature motif; other site 216595017613 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 216595017614 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 216595017615 Walker A/P-loop; other site 216595017616 ATP binding site [chemical binding]; other site 216595017617 Q-loop/lid; other site 216595017618 ABC transporter signature motif; other site 216595017619 Walker B; other site 216595017620 D-loop; other site 216595017621 H-loop/switch region; other site 216595017623 PS00017 ATP/GTP-binding site motif A (P-loop). 216595017624 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 216595017625 atcgggggcaagccccctcccaca 216595017626 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 216595017627 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 216595017628 active site 216595017629 non-prolyl cis peptide bond; other site 216595017630 atcgggggcaagccccctcccaca 216595017631 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216595017632 active site 216595017633 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 216595017634 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 216595017635 Flavin binding site [chemical binding]; other site 216595017638 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216595017639 non-specific DNA binding site [nucleotide binding]; other site 216595017640 salt bridge; other site 216595017641 sequence-specific DNA binding site [nucleotide binding]; other site 216595017642 Cupin domain; Region: Cupin_2; cl09118 216595017645 EamA-like transporter family; Region: EamA; cl01037 216595017646 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 216595017647 10 probable transmembrane helices predicted for PFLU3862 by TMHMM2.0 at aa 55-77, 81-100, 113-135, 140-159, 164-186, 196-217, 224-246, 250-272, 285-302 and 306-323 216595017650 19 probable transmembrane helices predicted for PFLU3863 by TMHMM2.0 at aa 2-24, 34-56, 77-99, 109-126, 133-152, 162-184, 204-226, 241-263, 270-292, 307-329, 363-385, 405-427, 459-481, 501-523, 574-596, 602-624, 631-653, 657-679 and 700-722 216595017653 5 probable transmembrane helices predicted for PFLU3864 by TMHMM2.0 at aa 15-32, 77-96, 106-128, 141-163 and 183-205 216595017655 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 216595017657 3 probable transmembrane helices predicted for PFLU3865 by TMHMM2.0 at aa 4-21, 28-50 and 75-97 216595017658 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 216595017659 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 216595017660 14 probable transmembrane helices predicted for PFLU3866 by TMHMM2.0 at aa 7-26, 36-55, 85-107, 122-144, 165-187, 214-236, 243-265, 280-302, 309-328, 332-354, 401-423, 427-449, 456-478 and 493-512 216595017662 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 216595017663 2 probable transmembrane helices predicted for PFLU3867 by TMHMM2.0 at aa 7-26 and 30-52 216595017665 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 216595017666 3 probable transmembrane helices predicted for PFLU3868 by TMHMM2.0 at aa 5-27, 37-59 and 66-88 216595017668 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 216595017670 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209 216595017671 NADP+ binding site [chemical binding]; other site 216595017672 folate binding site [chemical binding]; other site 216595017674 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 216595017675 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 216595017676 active site 216595017677 HIGH motif; other site 216595017678 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 216595017679 KMSKS motif; other site 216595017680 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 216595017681 tRNA binding surface [nucleotide binding]; other site 216595017682 anticodon binding site; other site 216595017685 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 216595017686 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 216595017687 active site 216595017688 HIGH motif; other site 216595017689 nucleotide binding site [chemical binding]; other site 216595017690 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 216595017691 KMSKS motif; other site 216595017692 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 216595017695 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 216595017696 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 216595017697 substrate binding site [chemical binding]; other site 216595017699 PS00170 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. 216595017700 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 216595017701 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 216595017702 putative active site [active] 216595017703 putative metal binding site [ion binding]; other site 216595017705 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 216595017706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595017707 putative substrate translocation pore; other site 216595017708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595017710 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595017711 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 216595017712 Outer membrane efflux protein; Region: OEP; pfam02321 216595017714 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 216595017715 1 probable transmembrane helix predicted for PFLU3876 by TMHMM2.0 at aa 24-43 216595017716 NodT family; Region: outer_NodT; TIGR01845 216595017717 Outer membrane efflux protein; Region: OEP; pfam02321 216595017718 Outer membrane efflux protein; Region: OEP; pfam02321 216595017720 PS00216 Sugar transport proteins signature 1. 216595017722 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595017723 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595017725 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 216595017726 Family of unknown function (DUF490); Region: DUF490; pfam04357 216595017727 Family of unknown function (DUF490); Region: DUF490; pfam04357 216595017729 1 probable transmembrane helix predicted for PFLU3879 by TMHMM2.0 at aa 7-29 216595017730 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 216595017731 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 216595017732 Surface antigen; Region: Bac_surface_Ag; cl03097 216595017735 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595017736 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 216595017738 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 216595017739 putative phosphate binding site [ion binding]; other site 216595017740 putative catalytic site [active] 216595017741 active site 216595017742 metal binding site A [ion binding]; metal-binding site 216595017743 DNA binding site [nucleotide binding] 216595017744 putative AP binding site [nucleotide binding]; other site 216595017745 putative metal binding site B [ion binding]; other site 216595017747 PS00726 AP endonucleases family 1 signature 1. 216595017748 PS00727 AP endonucleases family 1 signature 2. 216595017749 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595017750 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216595017751 ligand binding site [chemical binding]; other site 216595017752 1 probable transmembrane helix predicted for PFLU3883 by TMHMM2.0 at aa 5-24 216595017753 PS00017 ATP/GTP-binding site motif A (P-loop). 216595017755 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216595017756 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 216595017757 FAD binding site [chemical binding]; other site 216595017758 substrate binding site [chemical binding]; other site 216595017759 catalytic base [active] 216595017762 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 216595017763 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595017764 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 216595017765 substrate binding pocket [chemical binding]; other site 216595017766 dimerization interface [polypeptide binding]; other site 216595017768 PS00044 Bacterial regulatory proteins, lysR family signature. 216595017770 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 216595017771 DNA binding residues [nucleotide binding] 216595017772 putative dimer interface [polypeptide binding]; other site 216595017774 PS00552 Bacterial regulatory proteins, merR family signature. 216595017776 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 216595017777 active site 216595017778 catalytic residues [active] 216595017779 metal binding site [ion binding]; metal-binding site 216595017781 low G+C content region (39.66%) 216595017782 AMP-binding domain protein; Validated; Region: PRK08315 216595017783 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595017785 PS00455 Putative AMP-binding domain signature. 216595017786 isovaleryl-CoA dehydrogenase; Region: PLN02519 216595017787 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 216595017788 substrate binding site [chemical binding]; other site 216595017789 FAD binding site [chemical binding]; other site 216595017790 catalytic base [active] 216595017793 PS00072 Acyl-CoA dehydrogenases signature 1. 216595017795 PS00073 Acyl-CoA dehydrogenases signature 2. 216595017796 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 216595017797 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 216595017798 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 216595017800 gamma-carboxygeranoyl-CoA hydratase; Validated; Region: PRK05674 216595017801 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 216595017802 substrate binding site [chemical binding]; other site 216595017803 oxyanion hole (OAH) forming residues; other site 216595017804 trimer interface [polypeptide binding]; other site 216595017806 PS00166 Enoyl-CoA hydratase/isomerase signature. 216595017807 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 216595017808 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 216595017809 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 216595017810 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 216595017811 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 216595017812 carboxyltransferase (CT) interaction site; other site 216595017813 biotinylation site [posttranslational modification]; other site 216595017816 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 216595017817 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 216595017820 PS00188 Biotin-requiring enzymes attachment site. 216595017821 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 216595017822 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 216595017823 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 216595017824 Catalytic site [active] 216595017827 very low G+C content region (39.65%) 216595017828 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 216595017829 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 216595017830 active site 216595017831 Zn-binding site [ion binding]; other site 216595017833 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 216595017835 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 216595017836 putative heme binding pocket [chemical binding]; other site 216595017838 1 probable transmembrane helix predicted for PFLU3897 by TMHMM2.0 at aa 16-38 216595017839 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216595017840 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 216595017843 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 216595017844 1 probable transmembrane helix predicted for PFLU3899 by TMHMM2.0 at aa 83-105 216595017845 Spore Coat Protein U domain; Region: SCPU; cl02253 216595017846 putative pili subunits-related proteins 216595017849 1 probable transmembrane helix predicted for PFLU3900 by TMHMM2.0 at aa 7-29 216595017850 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 216595017851 pilin outer membrane usher protein SafC; Provisional; Region: PRK15223; cl14650 216595017853 PS01151 Fimbrial biogenesis outer membrane usher protein signature. 216595017854 1 probable transmembrane helix predicted for PFLU3901 by TMHMM2.0 at aa 20-39 216595017855 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 216595017856 putative fimbrial chaperone protein; Provisional; Region: PRK09918 216595017857 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595017858 Spore Coat Protein U domain; Region: SCPU; cl02253 216595017860 Spore Coat Protein U domain; Region: SCPU; cl02253 216595017862 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595017863 Spore Coat Protein U domain; Region: SCPU; cl02253 216595017865 Spore Coat Protein U domain; Region: SCPU; cl02253 216595017867 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 216595017868 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595017869 Walker A motif; other site 216595017870 ATP binding site [chemical binding]; other site 216595017871 Walker B motif; other site 216595017872 arginine finger; other site 216595017874 PS00017 ATP/GTP-binding site motif A (P-loop). 216595017875 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 216595017876 Catalytic domain of Protein Kinases; Region: PKc; cd00180 216595017877 active site 216595017878 ATP binding site [chemical binding]; other site 216595017879 substrate binding site [chemical binding]; other site 216595017880 activation loop (A-loop); other site 216595017886 PS00107 Protein kinases ATP-binding region signature. 216595017887 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595017888 Domain of unknown function DUF28; Region: DUF28; cl00361 216595017890 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595017891 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 216595017892 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 216595017893 dimerization interface [polypeptide binding]; other site 216595017896 PS00044 Bacterial regulatory proteins, lysR family signature. 216595017897 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 216595017898 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 216595017899 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216595017900 catalytic residue [active] 216595017902 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 216595017903 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 216595017905 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 216595017907 4 probable transmembrane helices predicted for PFLU3913 by TMHMM2.0 at aa 20-37, 52-74, 95-117 and 155-174 216595017908 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595017909 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 216595017910 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 216595017911 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 216595017912 PS00687 Aldehyde dehydrogenases glutamic acid active site. 216595017913 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 216595017914 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 216595017915 active site 216595017916 FMN binding site [chemical binding]; other site 216595017917 2,4-decadienoyl-CoA binding site; other site 216595017918 catalytic residue [active] 216595017919 4Fe-4S cluster binding site [ion binding]; other site 216595017920 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 216595017924 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216595017925 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 216595017926 active site 216595017927 catalytic triad [active] 216595017928 dimer interface [polypeptide binding]; other site 216595017929 1 probable transmembrane helix predicted for PFLU3916 by TMHMM2.0 at aa 27-46 216595017931 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 216595017932 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216595017934 2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012 216595017936 Transcriptional regulators [Transcription]; Region: MarR; COG1846 216595017937 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595017939 PS01117 Bacterial regulatory proteins, marR family signature. 216595017940 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 216595017941 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 216595017942 dimer interface [polypeptide binding]; other site 216595017943 TPP-binding site [chemical binding]; other site 216595017944 Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001 216595017945 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595017946 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595017947 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595017948 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 216595017949 putative effector binding pocket; other site 216595017950 putative dimerization interface [polypeptide binding]; other site 216595017953 PS00044 Bacterial regulatory proteins, lysR family signature. 216595017954 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595017955 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216595017956 putative substrate translocation pore; other site 216595017957 12 probable transmembrane helices predicted for PFLU3923 by TMHMM2.0 at aa 58-80, 95-117, 124-146, 151-170, 183-205, 209-231, 266-288, 293-312, 319-338, 342-361, 381-403 and 407-424 216595017960 periplasmic folding chaperone; Provisional; Region: PRK10788 216595017961 SurA N-terminal domain; Region: SurA_N; pfam09312 216595017962 PPIC-type PPIASE domain; Region: Rotamase; cl08278 216595017963 PS00017 ATP/GTP-binding site motif A (P-loop). 216595017965 PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature. 216595017967 1 probable transmembrane helix predicted for PFLU3925 by TMHMM2.0 at aa 12-34 216595017968 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 216595017969 IHF - DNA interface [nucleotide binding]; other site 216595017970 IHF dimer interface [polypeptide binding]; other site 216595017972 PS00045 Bacterial histone-like DNA-binding proteins signature. 216595017973 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 216595017974 Found in ATP-dependent protease La (LON); Region: LON; smart00464 216595017975 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595017976 Walker A motif; other site 216595017977 ATP binding site [chemical binding]; other site 216595017978 Walker B motif; other site 216595017979 arginine finger; other site 216595017980 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 216595017983 PS00017 ATP/GTP-binding site motif A (P-loop). 216595017985 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 216595017986 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 216595017987 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595017988 Walker A motif; other site 216595017989 ATP binding site [chemical binding]; other site 216595017990 Walker B motif; other site 216595017991 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 216595017993 PS00017 ATP/GTP-binding site motif A (P-loop). 216595017995 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 216595017996 oligomer interface [polypeptide binding]; other site 216595017997 active site residues [active] 216595017999 PS00382 Endopeptidase Clp histidine active site. 216595018000 PS00381 Endopeptidase Clp serine active site. 216595018001 trigger factor; Provisional; Region: tig; PRK01490 216595018002 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 216595018003 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 216595018007 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 216595018008 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 216595018009 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 216595018010 homodimer interface [polypeptide binding]; other site 216595018011 NADP binding site [chemical binding]; other site 216595018012 substrate binding site [chemical binding]; other site 216595018013 PS00017 ATP/GTP-binding site motif A (P-loop). 216595018016 Beta-lactamase; Region: Beta-lactamase; cl01009 216595018017 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 216595018019 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 216595018020 putative active site [active] 216595018021 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595018022 1 probable transmembrane helix predicted for PFLU3934 by TMHMM2.0 at aa 21-43 216595018023 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595018024 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 216595018026 10 probable transmembrane helices predicted for PFLU3936 by TMHMM2.0 at aa 21-40, 369-391, 442-464, 469-488, 570-589, 911-933, 940-959, 969-991, 1011-1033 and 1043-1065 216595018027 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 216595018028 PS00138 Serine proteases, subtilase family, serine active site. 216595018029 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 216595018030 1 probable transmembrane helix predicted for PFLU3937 by TMHMM2.0 at aa 12-31 216595018032 NodT family; Region: outer_NodT; TIGR01845 216595018033 Outer membrane efflux protein; Region: OEP; pfam02321 216595018034 Outer membrane efflux protein; Region: OEP; pfam02321 216595018035 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595018038 Transposase IS200 like; Region: Y1_Tnp; cl00848 216595018040 allantoate amidohydrolase; Reviewed; Region: PRK12893 216595018041 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 216595018042 active site 216595018043 metal binding site [ion binding]; metal-binding site 216595018044 dimer interface [polypeptide binding]; other site 216595018047 Sodium:solute symporter family; Region: SSF; cl00456 216595018049 low G+C content region (45.1%) 216595018050 phenylhydantoinase; Validated; Region: PRK08323 216595018051 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like...; Region: D-HYD; cd01314 216595018052 tetramer interface [polypeptide binding]; other site 216595018053 active site 216595018055 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 216595018056 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595018058 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 216595018059 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 216595018060 homodimer interface [polypeptide binding]; other site 216595018061 active site 216595018062 FMN binding site [chemical binding]; other site 216595018063 substrate binding site [chemical binding]; other site 216595018064 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 216595018067 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216595018069 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216595018070 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 216595018071 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216595018072 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 216595018075 Copper resistance protein CopC; Region: CopC; cl01012 216595018077 Copper resistance protein D; Region: CopD; cl00563 216595018079 8 probable transmembrane helices predicted for PFLU3947 by TMHMM2.0 at aa 10-32, 48-70, 90-109, 114-136, 146-168, 181-203, 218-240 and 260-282 216595018080 outer membrane porin, OprD family; Region: OprD; pfam03573 216595018082 PS00309 Galaptin signature. 216595018083 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595018084 active site 216595018086 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 216595018088 Class II transport system: TRAP 216595018089 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 216595018091 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 216595018092 4 probable transmembrane helices predicted for PFLU3952 by TMHMM2.0 at aa 28-50, 65-82, 103-122 and 145-167 216595018094 DctM-like transporters; Region: DctM; pfam06808 216595018095 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 216595018096 11 probable transmembrane helices predicted for PFLU3953 by TMHMM2.0 at aa 5-27, 42-64, 77-99, 171-193, 217-239, 243-257, 277-299, 314-331, 336-353, 363-385 and 397-419 216595018098 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 216595018099 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 216595018100 active site 216595018101 catalytic residues [active] 216595018103 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 216595018105 1 probable transmembrane helix predicted for PFLU3955 by TMHMM2.0 at aa 12-34 216595018106 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216595018107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595018108 putative substrate translocation pore; other site 216595018110 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 216595018111 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 216595018112 transmembrane helices; other site 216595018114 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 216595018115 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 216595018116 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 216595018118 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 216595018120 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 216595018122 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 216595018123 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595018124 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595018125 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595018128 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 216595018129 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595018131 PS00519 Bacterial regulatory proteins, asnC family signature. 216595018132 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 216595018133 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 216595018134 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 216595018135 tetramer interface [polypeptide binding]; other site 216595018136 TPP-binding site [chemical binding]; other site 216595018137 heterodimer interface [polypeptide binding]; other site 216595018138 phosphorylation loop region [posttranslational modification] 216595018140 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 216595018141 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 216595018142 alpha subunit interface [polypeptide binding]; other site 216595018143 TPP binding site [chemical binding]; other site 216595018144 heterodimer interface [polypeptide binding]; other site 216595018145 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 216595018148 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 216595018149 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 216595018150 E3 interaction surface; other site 216595018151 lipoyl attachment site [posttranslational modification]; other site 216595018152 e3 binding domain; Region: E3_binding; pfam02817 216595018153 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 216595018157 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 216595018158 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595018159 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 216595018161 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 216595018162 PS00017 ATP/GTP-binding site motif A (P-loop). 216595018164 PS00017 ATP/GTP-binding site motif A (P-loop). 216595018166 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 216595018167 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557 216595018168 homodimer interface [polypeptide binding]; other site 216595018169 substrate-cofactor binding pocket; other site 216595018170 catalytic residue [active] 216595018172 PS00770 Aminotransferases class-IV signature. 216595018173 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 216595018174 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216595018175 Coenzyme A binding pocket [chemical binding]; other site 216595018178 ornithine cyclodeaminase; Validated; Region: PRK07589 216595018179 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595018181 PS00017 ATP/GTP-binding site motif A (P-loop). 216595018182 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595018184 Transposase; Region: DEDD_Tnp_IS110; pfam01548 216595018185 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 216595018188 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 216595018189 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 216595018190 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 216595018192 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 216595018193 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216595018194 RNA polymerase sigma factor; Reviewed; Region: PRK12527 216595018195 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 216595018198 macrolide transporter subunit MacA; Provisional; Region: PRK11578 216595018199 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404 216595018200 1 probable transmembrane helix predicted for PFLU3977 by TMHMM2.0 at aa 41-60 216595018202 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 216595018203 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 216595018204 Walker A/P-loop; other site 216595018205 ATP binding site [chemical binding]; other site 216595018206 Q-loop/lid; other site 216595018207 ABC transporter signature motif; other site 216595018208 Walker B; other site 216595018209 D-loop; other site 216595018210 H-loop/switch region; other site 216595018211 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 216595018212 FtsX-like permease family; Region: FtsX; pfam02687 216595018214 PS00017 ATP/GTP-binding site motif A (P-loop). 216595018215 PS00211 ABC transporters family signature. 216595018216 4 probable transmembrane helices predicted for PFLU3978 by TMHMM2.0 at aa 283-305, 531-553, 588-610 and 617-639 216595018218 NodT family; Region: outer_NodT; TIGR01845 216595018219 Outer membrane efflux protein; Region: OEP; pfam02321 216595018220 Outer membrane efflux protein; Region: OEP; pfam02321 216595018221 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595018224 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 216595018226 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216595018227 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595018228 DNA-binding site [nucleotide binding]; DNA binding site 216595018229 FCD domain; Region: FCD; cl11656 216595018232 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 216595018233 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 216595018234 putative ligand binding site [chemical binding]; other site 216595018235 PS00294 Prenyl group binding site (CAAX box). 216595018236 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 216595018237 TM-ABC transporter signature motif; other site 216595018239 8 probable transmembrane helices predicted for PFLU3983 by TMHMM2.0 at aa 15-33, 35-57, 62-84, 96-118, 138-160, 189-211, 226-248 and 255-277 216595018240 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 216595018241 TM-ABC transporter signature motif; other site 216595018242 9 probable transmembrane helices predicted for PFLU3984 by TMHMM2.0 at aa 16-38, 42-64, 66-83, 87-109, 114-136, 166-188, 219-241, 256-278 and 291-313 216595018244 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 216595018245 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 216595018246 Walker A/P-loop; other site 216595018247 ATP binding site [chemical binding]; other site 216595018248 Q-loop/lid; other site 216595018249 ABC transporter signature motif; other site 216595018250 Walker B; other site 216595018251 D-loop; other site 216595018252 H-loop/switch region; other site 216595018254 PS00017 ATP/GTP-binding site motif A (P-loop). 216595018255 PS00211 ABC transporters family signature. 216595018256 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 216595018257 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 216595018258 Walker A/P-loop; other site 216595018259 ATP binding site [chemical binding]; other site 216595018260 Q-loop/lid; other site 216595018261 ABC transporter signature motif; other site 216595018262 Walker B; other site 216595018263 D-loop; other site 216595018264 H-loop/switch region; other site 216595018266 PS00017 ATP/GTP-binding site motif A (P-loop). 216595018267 PS00211 ABC transporters family signature. 216595018268 allantoate amidohydrolase; Reviewed; Region: PRK12893 216595018269 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 216595018270 active site 216595018271 metal binding site [ion binding]; metal-binding site 216595018272 dimer interface [polypeptide binding]; other site 216595018275 putative amidase; Provisional; Region: PRK06169 216595018276 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 216595018278 PS00017 ATP/GTP-binding site motif A (P-loop). 216595018279 transcriptional regulator HdfR; Provisional; Region: PRK03601 216595018280 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595018281 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595018283 PS00044 Bacterial regulatory proteins, lysR family signature. 216595018285 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216595018286 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216595018287 DNA binding site [nucleotide binding] 216595018288 domain linker motif; other site 216595018289 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 216595018290 dimerization interface [polypeptide binding]; other site 216595018291 ligand binding site [chemical binding]; other site 216595018294 short chain dehydrogenase; Provisional; Region: PRK07060 216595018295 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595018296 NAD(P) binding site [chemical binding]; other site 216595018297 active site 216595018299 PS00061 Short-chain dehydrogenases/reductases family signature. 216595018300 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 216595018301 uncharacterized xylulose kinase-like proteins, subgroup 1; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 216595018302 N- and C-terminal domain interface [polypeptide binding]; other site 216595018303 putative active site [active] 216595018304 catalytic site [active] 216595018305 metal binding site [ion binding]; metal-binding site 216595018306 putative xylulose binding site [chemical binding]; other site 216595018307 putative ATP binding site [chemical binding]; other site 216595018308 putative homodimer interface [polypeptide binding]; other site 216595018310 PS00445 FGGY family of carbohydrate kinases signature 2. 216595018312 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 216595018313 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 216595018314 NAD(P) binding site [chemical binding]; other site 216595018317 PS00059 Zinc-containing alcohol dehydrogenases signature. 216595018318 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216595018319 TM-ABC transporter signature motif; other site 216595018321 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 216595018322 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 216595018323 Walker A/P-loop; other site 216595018324 ATP binding site [chemical binding]; other site 216595018325 Q-loop/lid; other site 216595018326 ABC transporter signature motif; other site 216595018327 Walker B; other site 216595018328 D-loop; other site 216595018329 H-loop/switch region; other site 216595018330 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 216595018332 PS00211 ABC transporters family signature. 216595018334 PS00017 ATP/GTP-binding site motif A (P-loop). 216595018335 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 216595018336 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 216595018337 putative ligand binding site [chemical binding]; other site 216595018339 PS00687 Aldehyde dehydrogenases glutamic acid active site. 216595018340 4 probable transmembrane helices predicted for PFLU3997 by TMHMM2.0 at aa 20-42, 47-69, 111-133 and 137-159 216595018342 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595018343 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 216595018344 Strictosidine synthase; Region: Str_synth; pfam03088 216595018346 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 216595018347 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595018348 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 216595018351 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 216595018352 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 216595018353 Walker A/P-loop; other site 216595018354 ATP binding site [chemical binding]; other site 216595018355 Q-loop/lid; other site 216595018356 ABC transporter signature motif; other site 216595018357 Walker B; other site 216595018358 D-loop; other site 216595018359 H-loop/switch region; other site 216595018361 PS00211 ABC transporters family signature. 216595018362 PS00017 ATP/GTP-binding site motif A (P-loop). 216595018363 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 216595018364 catalytic core [active] 216595018365 1 probable transmembrane helix predicted for PFLU4003 by TMHMM2.0 at aa 28-47 216595018367 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 216595018368 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 216595018370 11 probable transmembrane helices predicted for PFLU4004 by TMHMM2.0 at aa 7-29, 80-102, 115-132, 163-197, 204-226, 257-279, 291-308, 313-332, 345-367, 377-399 and 406-428 216595018371 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 216595018373 9 probable transmembrane helices predicted for PFLU4005 by TMHMM2.0 at aa 12-34, 85-107, 128-150, 170-192, 205-227, 265-287, 299-316, 320-342 and 354-373 216595018374 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 216595018375 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 216595018376 Walker A/P-loop; other site 216595018377 ATP binding site [chemical binding]; other site 216595018378 Q-loop/lid; other site 216595018379 ABC transporter signature motif; other site 216595018380 Walker B; other site 216595018381 D-loop; other site 216595018382 H-loop/switch region; other site 216595018384 PS00017 ATP/GTP-binding site motif A (P-loop). 216595018385 low G+C contetn region (47.92%) 216595018386 Condensation domain; Region: Condensation; cl09290 216595018387 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216595018388 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595018389 Phosphopantetheine attachment site; Region: PP-binding; cl09936 216595018390 Condensation domain; Region: Condensation; cl09290 216595018391 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216595018392 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595018393 Phosphopantetheine attachment site; Region: PP-binding; cl09936 216595018395 PS00012 Phosphopantetheine attachment site. 216595018397 PS00455 Putative AMP-binding domain signature. 216595018400 PS00012 Phosphopantetheine attachment site. 216595018402 PS00455 Putative AMP-binding domain signature. 216595018404 low G+C content region (45.08%) 216595018405 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595018407 NodT family; Region: outer_NodT; TIGR01845 216595018408 Outer membrane efflux protein; Region: OEP; pfam02321 216595018409 Outer membrane efflux protein; Region: OEP; pfam02321 216595018412 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 216595018413 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 216595018416 Uncharacterised protein family (UPF0014); Region: UPF0014; cl00424 216595018418 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 216595018419 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 216595018420 Walker A/P-loop; other site 216595018421 ATP binding site [chemical binding]; other site 216595018422 Q-loop/lid; other site 216595018423 ABC transporter signature motif; other site 216595018424 Walker B; other site 216595018425 D-loop; other site 216595018426 H-loop/switch region; other site 216595018428 PS00211 ABC transporters family signature. 216595018429 PS00017 ATP/GTP-binding site motif A (P-loop). 216595018430 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 216595018431 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 216595018432 active site 216595018433 catalytic tetrad [active] 216595018435 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216595018436 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595018437 substrate binding pocket [chemical binding]; other site 216595018438 membrane-bound complex binding site; other site 216595018439 hinge residues; other site 216595018441 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 216595018442 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 216595018443 Walker A/P-loop; other site 216595018444 ATP binding site [chemical binding]; other site 216595018445 Q-loop/lid; other site 216595018446 ABC transporter signature motif; other site 216595018447 Walker B; other site 216595018448 D-loop; other site 216595018449 H-loop/switch region; other site 216595018451 PS00211 ABC transporters family signature. 216595018452 PS00017 ATP/GTP-binding site motif A (P-loop). 216595018453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595018454 dimer interface [polypeptide binding]; other site 216595018455 conserved gate region; other site 216595018456 putative PBP binding loops; other site 216595018457 ABC-ATPase subunit interface; other site 216595018459 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595018460 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216595018461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595018462 dimer interface [polypeptide binding]; other site 216595018463 conserved gate region; other site 216595018464 putative PBP binding loops; other site 216595018465 ABC-ATPase subunit interface; other site 216595018467 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595018468 classical (c) SDRs; Region: SDR_c; cd05233 216595018469 NAD(P) binding site [chemical binding]; other site 216595018470 active site 216595018472 LamB/YcsF family; Region: LamB_YcsF; cl00664 216595018474 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 216595018475 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 216595018477 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 216595018478 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 216595018480 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 216595018481 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 216595018482 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 216595018483 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 216595018486 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 216595018487 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 216595018489 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 216595018490 carboxyltransferase (CT) interaction site; other site 216595018491 biotinylation site [posttranslational modification]; other site 216595018493 PS00188 Biotin-requiring enzymes attachment site. 216595018494 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 216595018495 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595018496 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 216595018497 putative dimerization interface [polypeptide binding]; other site 216595018500 PS00044 Bacterial regulatory proteins, lysR family signature. 216595018501 hypothetical protein; Validated; Region: PRK07682 216595018502 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216595018503 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595018504 homodimer interface [polypeptide binding]; other site 216595018505 catalytic residue [active] 216595018507 PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 216595018508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595018509 putative substrate translocation pore; other site 216595018510 14 probable transmembrane helices predicted for PFLU4028 by TMHMM2.0 at aa 13-35, 55-74, 81-100, 110-132, 144-166, 171-193, 206-228, 232-251, 272-291, 306-328, 337-359, 363-385, 405-427 and 469-491 216595018512 outer membrane porin, OprD family; Region: OprD; pfam03573 216595018514 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 216595018515 active site 216595018516 motif I; other site 216595018517 motif II; other site 216595018518 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595018520 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595018521 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216595018522 substrate binding pocket [chemical binding]; other site 216595018523 membrane-bound complex binding site; other site 216595018524 hinge residues; other site 216595018526 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 216595018527 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216595018528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595018529 dimer interface [polypeptide binding]; other site 216595018530 conserved gate region; other site 216595018531 putative PBP binding loops; other site 216595018532 ABC-ATPase subunit interface; other site 216595018533 5 probable transmembrane helices predicted for PFLU4032 by TMHMM2.0 at aa 27-45, 74-96, 103-125, 135-157 and 240-262 216595018535 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 216595018536 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 216595018537 active site 216595018538 non-prolyl cis peptide bond; other site 216595018539 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 216595018540 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595018542 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 216595018543 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 216595018544 inhibitor-cofactor binding pocket; inhibition site 216595018545 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595018546 catalytic residue [active] 216595018548 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 216595018549 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 216595018550 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595018552 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 216595018553 isocitrate dehydrogenase; Validated; Region: PRK06451 216595018555 PS00470 Isocitrate and isopropylmalate dehydrogenases signature. 216595018556 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216595018557 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 216595018558 tetramerization interface [polypeptide binding]; other site 216595018559 NAD(P) binding site [chemical binding]; other site 216595018560 catalytic residues [active] 216595018562 PS00070 Aldehyde dehydrogenases cysteine active site. 216595018563 PS00687 Aldehyde dehydrogenases glutamic acid active site. 216595018564 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 216595018565 acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892 216595018566 metal binding site [ion binding]; metal-binding site 216595018567 putative dimer interface [polypeptide binding]; other site 216595018570 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 216595018571 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 216595018572 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 216595018574 1 probable transmembrane helix predicted for PFLU4041 by TMHMM2.0 at aa 7-24 216595018575 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 216595018576 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595018577 A subunit; Region: glycerol3P_GlpA; TIGR03377 216595018580 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 216595018581 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 216595018582 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 216595018583 Walker A/P-loop; other site 216595018584 ATP binding site [chemical binding]; other site 216595018585 Q-loop/lid; other site 216595018586 ABC transporter signature motif; other site 216595018587 Walker B; other site 216595018588 D-loop; other site 216595018589 H-loop/switch region; other site 216595018590 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 216595018591 Walker A/P-loop; other site 216595018592 ATP binding site [chemical binding]; other site 216595018593 Q-loop/lid; other site 216595018594 ABC transporter signature motif; other site 216595018595 Walker B; other site 216595018596 D-loop; other site 216595018597 H-loop/switch region; other site 216595018598 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216595018601 PS00211 ABC transporters family signature. 216595018602 PS00017 ATP/GTP-binding site motif A (P-loop). 216595018604 PS00017 ATP/GTP-binding site motif A (P-loop). 216595018605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595018606 dimer interface [polypeptide binding]; other site 216595018607 conserved gate region; other site 216595018608 ABC-ATPase subunit interface; other site 216595018610 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216595018611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595018612 dimer interface [polypeptide binding]; other site 216595018613 conserved gate region; other site 216595018614 putative PBP binding loops; other site 216595018615 ABC-ATPase subunit interface; other site 216595018617 PS00962 Ribosomal protein S2 signature 1. 216595018618 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 216595018619 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 216595018621 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 216595018622 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 216595018623 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 216595018625 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 216595018626 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 216595018628 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 216595018629 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216595018630 Coenzyme A binding pocket [chemical binding]; other site 216595018632 Cupin domain; Region: Cupin_2; cl09118 216595018634 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595018635 transcriptional activator TtdR; Provisional; Region: PRK09801 216595018636 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 216595018637 putative effector binding pocket; other site 216595018638 putative dimerization interface [polypeptide binding]; other site 216595018641 PS00044 Bacterial regulatory proteins, lysR family signature. 216595018642 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812 216595018643 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 216595018644 dimer interface [polypeptide binding]; other site 216595018645 active site 216595018646 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 216595018647 substrate binding site [chemical binding]; other site 216595018648 catalytic residue [active] 216595018650 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 216595018651 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 216595018653 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216595018654 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 216595018655 Coenzyme A binding pocket [chemical binding]; other site 216595018657 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 216595018658 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216595018659 NAD binding site [chemical binding]; other site 216595018660 catalytic residues [active] 216595018662 PS00070 Aldehyde dehydrogenases cysteine active site. 216595018663 Protein of unknown function (DUF796); Region: DUF796; cl01226 216595018665 4 probable transmembrane helices predicted for PFLU4059 by TMHMM2.0 at aa 30-52, 56-78, 90-112 and 116-135 216595018666 PS00237 G-protein coupled receptors signature. 216595018667 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 216595018668 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 216595018669 active site 216595018670 non-prolyl cis peptide bond; other site 216595018671 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216595018672 ligand binding site [chemical binding]; other site 216595018674 PS01068 OmpA-like domain. 216595018675 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595018676 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 216595018677 Cytochrome c; Region: Cytochrom_C; cl11414 216595018678 PS00017 ATP/GTP-binding site motif A (P-loop). 216595018679 PS00190 Cytochrome c family heme-binding site signature. 216595018680 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_3; cd06151 216595018681 homotrimer interaction site [polypeptide binding]; other site 216595018682 putative active site [active] 216595018684 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 216595018685 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595018687 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216595018688 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595018689 substrate binding pocket [chemical binding]; other site 216595018690 membrane-bound complex binding site; other site 216595018691 hinge residues; other site 216595018693 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 216595018694 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 216595018695 Walker A/P-loop; other site 216595018696 ATP binding site [chemical binding]; other site 216595018697 Q-loop/lid; other site 216595018698 ABC transporter signature motif; other site 216595018699 Walker B; other site 216595018700 D-loop; other site 216595018701 H-loop/switch region; other site 216595018703 PS00211 ABC transporters family signature. 216595018704 PS00017 ATP/GTP-binding site motif A (P-loop). 216595018705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595018706 dimer interface [polypeptide binding]; other site 216595018707 conserved gate region; other site 216595018708 putative PBP binding loops; other site 216595018709 ABC-ATPase subunit interface; other site 216595018711 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595018712 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 216595018713 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216595018714 N-terminal plug; other site 216595018715 ligand-binding site [chemical binding]; other site 216595018717 PS00017 ATP/GTP-binding site motif A (P-loop). 216595018719 type II secretion system secreton cluster 3 216595018720 general secretion pathway protein D; Region: type_II_gspD; TIGR02517 216595018721 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 216595018722 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 216595018723 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 216595018724 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 216595018729 1 probable transmembrane helix predicted for PFLU4071 by TMHMM2.0 at aa 7-29 216595018730 General secretion pathway protein M; Region: GspM_II; pfam10741 216595018731 1 probable transmembrane helix predicted for PFLU4072 by TMHMM2.0 at aa 13-35 216595018732 GspL cytoplasmic actin-ATPase-like region; Region: GspL; pfam05134 216595018733 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 216595018736 1 probable transmembrane helix predicted for PFLU4074 by TMHMM2.0 at aa 7-29 216595018737 general secretion pathway protein J; Validated; Region: PRK08808 216595018738 1 probable transmembrane helix predicted for PFLU4075 by TMHMM2.0 at aa 13-35 216595018740 PS00409 Prokaryotic N-terminal methylation site. 216595018741 1 probable transmembrane helix predicted for PFLU4076 by TMHMM2.0 at aa 7-29 216595018743 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 216595018744 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 216595018746 1 probable transmembrane helix predicted for PFLU4077 by TMHMM2.0 at aa 7-29 216595018747 PS00409 Prokaryotic N-terminal methylation site. 216595018748 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 216595018749 general secretion pathway protein G; Region: typeII_sec_gspG; TIGR01710 216595018750 Bacterial type II secretion system protein G; Region: GSPII_G; pfam08334 216595018753 1 probable transmembrane helix predicted for PFLU4078 by TMHMM2.0 at aa 13-35 216595018754 PS00409 Prokaryotic N-terminal methylation site. 216595018755 general secretion pathway protein F; Region: GspF; TIGR02120 216595018756 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 216595018757 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 216595018760 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 216595018761 general secretory pathway protein E; Region: type_II_gspE; TIGR02533 216595018762 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 216595018763 Walker A motif; other site 216595018764 ATP binding site [chemical binding]; other site 216595018765 Walker B motif; other site 216595018767 PS00662 Bacterial type II secretion system protein E signature. 216595018768 PS00017 ATP/GTP-binding site motif A (P-loop). 216595018770 low G+C content region (49.94%) 216595018771 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 216595018772 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 216595018773 PA14 domain; Region: PA14; cl08459 216595018774 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 216595018778 PS00018 EF-hand calcium-binding domain. 216595018780 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216595018781 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216595018782 DNA binding site [nucleotide binding] 216595018783 domain linker motif; other site 216595018784 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 216595018785 putative ligand binding site [chemical binding]; other site 216595018786 putative dimerization interface [polypeptide binding]; other site 216595018789 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 216595018790 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216595018791 N-terminal plug; other site 216595018792 ligand-binding site [chemical binding]; other site 216595018795 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 216595018796 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 216595018797 active site 216595018798 non-prolyl cis peptide bond; other site 216595018799 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 216595018800 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595018801 substrate binding pocket [chemical binding]; other site 216595018802 membrane-bound complex binding site; other site 216595018803 hinge residues; other site 216595018805 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 216595018806 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 216595018807 Walker A/P-loop; other site 216595018808 ATP binding site [chemical binding]; other site 216595018809 Q-loop/lid; other site 216595018810 ABC transporter signature motif; other site 216595018811 Walker B; other site 216595018812 D-loop; other site 216595018813 H-loop/switch region; other site 216595018815 PS00211 ABC transporters family signature. 216595018816 PS00017 ATP/GTP-binding site motif A (P-loop). 216595018817 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 216595018818 ABC-ATPase subunit interface; other site 216595018819 dimer interface [polypeptide binding]; other site 216595018820 putative PBP binding regions; other site 216595018822 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 216595018823 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 216595018824 putative PBP binding regions; other site 216595018825 ABC-ATPase subunit interface; other site 216595018827 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 216595018828 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor...; Region: FhuD; cd01146 216595018829 siderophore binding site; other site 216595018832 Secretin and TonB N terminus short domain; Region: STN; cl06624 216595018833 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 216595018834 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216595018835 N-terminal plug; other site 216595018836 ligand-binding site [chemical binding]; other site 216595018838 PS01156 TonB-dependent receptor proteins signature 2. 216595018841 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 216595018842 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595018843 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595018845 PS00519 Bacterial regulatory proteins, asnC family signature. 216595018846 14 probable transmembrane helices predicted for PFLU4095 by TMHMM2.0 at aa 20-39, 49-71, 78-97, 131-153, 158-180, 190-212, 217-236, 246-265, 278-300, 310-330, 351-373, 383-405, 426-448 and 463-485 216595018847 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 216595018848 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 216595018850 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 216595018851 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 216595018852 Walker A/P-loop; other site 216595018853 ATP binding site [chemical binding]; other site 216595018854 Q-loop/lid; other site 216595018855 ABC transporter signature motif; other site 216595018856 Walker B; other site 216595018857 D-loop; other site 216595018858 H-loop/switch region; other site 216595018859 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216595018861 PS00211 ABC transporters family signature. 216595018862 PS00017 ATP/GTP-binding site motif A (P-loop). 216595018863 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216595018864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595018865 dimer interface [polypeptide binding]; other site 216595018866 conserved gate region; other site 216595018867 putative PBP binding loops; other site 216595018868 ABC-ATPase subunit interface; other site 216595018870 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595018871 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216595018872 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595018873 substrate binding pocket [chemical binding]; other site 216595018874 membrane-bound complex binding site; other site 216595018875 hinge residues; other site 216595018877 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595018878 DNA-binding site [nucleotide binding]; DNA binding site 216595018879 FCD domain; Region: FCD; cl11656 216595018882 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216595018883 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595018884 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595018885 dimer interface [polypeptide binding]; other site 216595018886 phosphorylation site [posttranslational modification] 216595018887 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595018888 ATP binding site [chemical binding]; other site 216595018889 Mg2+ binding site [ion binding]; other site 216595018890 G-X-G motif; other site 216595018894 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 216595018895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595018896 active site 216595018897 phosphorylation site [posttranslational modification] 216595018898 intermolecular recognition site; other site 216595018899 dimerization interface [polypeptide binding]; other site 216595018900 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 216595018901 DNA binding site [nucleotide binding] 216595018904 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 216595018905 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 216595018906 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 216595018907 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 216595018908 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 216595018909 Surface antigen; Region: Bac_surface_Ag; cl03097 216595018916 Protein involved in meta-pathway of phenol degradation [Energy production and conversion]; Region: COG4313 216595018917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595018918 putative substrate translocation pore; other site 216595018919 12 probable transmembrane helices predicted for PFLU4106 by TMHMM2.0 at aa 13-35, 50-72, 79-97, 101-123, 135-157, 162-181, 201-223, 238-260, 265-287, 291-313, 326-348 and 353-375 216595018921 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 216595018922 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 216595018924 low G+C content region (49.51%) 216595018925 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 216595018927 Transcriptional regulator [Transcription]; Region: IclR; COG1414 216595018928 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595018929 Bacterial transcriptional regulator; Region: IclR; pfam01614 216595018932 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 216595018933 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595018934 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595018936 PS00283 Soybean trypsin inhibitor (Kunitz) protease inhibitors family signature. 216595018937 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 216595018938 active site 216595018939 metal binding site [ion binding]; metal-binding site 216595018940 C-terminal domain of type I, class II extradiol dioxygenases; catalytic domain; Region: ED_TypeI_classII_C; cd08343 216595018941 active site 216595018942 metal binding site [ion binding]; metal-binding site 216595018944 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 216595018945 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216595018946 NAD(P) binding site [chemical binding]; other site 216595018947 catalytic residues [active] 216595018949 PS00687 Aldehyde dehydrogenases glutamic acid active site. 216595018950 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 216595018951 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595018954 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 216595018955 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595018957 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 216595018958 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 216595018959 putative NAD(P) binding site [chemical binding]; other site 216595018960 catalytic Zn binding site [ion binding]; other site 216595018961 structural Zn binding site [ion binding]; other site 216595018963 PS00059 Zinc-containing alcohol dehydrogenases signature. 216595018965 CHASE domain; Region: CHASE; cl01369 216595018966 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216595018967 metal binding site [ion binding]; metal-binding site 216595018968 active site 216595018969 I-site; other site 216595018970 2 probable transmembrane helices predicted for PFLU4116 by TMHMM2.0 at aa 24-46 and 318-340 216595018972 VacJ like lipoprotein; Region: VacJ; cl01073 216595018974 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595018975 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 216595018976 Outer membrane efflux protein; Region: OEP; pfam02321 216595018977 Outer membrane efflux protein; Region: OEP; pfam02321 216595018980 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595018981 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 216595018982 Protein export membrane protein; Region: SecD_SecF; cl14618 216595018984 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 216595018985 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 216595018987 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595018988 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 216595018989 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 216595018990 dimerization interface [polypeptide binding]; other site 216595018991 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595018992 dimer interface [polypeptide binding]; other site 216595018993 phosphorylation site [posttranslational modification] 216595018994 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595018995 ATP binding site [chemical binding]; other site 216595018996 Mg2+ binding site [ion binding]; other site 216595018997 G-X-G motif; other site 216595018998 2 probable transmembrane helices predicted for PFLU4121 by TMHMM2.0 at aa 10-32 and 166-185 216595019002 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 216595019003 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595019004 active site 216595019005 phosphorylation site [posttranslational modification] 216595019006 intermolecular recognition site; other site 216595019007 dimerization interface [polypeptide binding]; other site 216595019008 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 216595019009 DNA binding site [nucleotide binding] 216595019012 Prophage 4 216595019013 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 216595019014 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595019015 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595019016 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595019017 2 probable transmembrane helices predicted for PFLU4125 by TMHMM2.0 at aa 32-54 and 214-236 216595019020 GAF domain; Region: GAF; cl00853 216595019022 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 216595019023 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 216595019024 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 216595019025 catalytic residue [active] 216595019027 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 216595019030 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 216595019032 PS00430 TonB-dependent receptor proteins signature 1. 216595019034 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 216595019036 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 216595019037 DNA binding residues [nucleotide binding] 216595019039 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 216595019040 IHF dimer interface [polypeptide binding]; other site 216595019041 IHF - DNA interface [nucleotide binding]; other site 216595019043 PS00045 Bacterial histone-like DNA-binding proteins signature. 216595019044 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 216595019045 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 216595019046 putative tRNA-binding site [nucleotide binding]; other site 216595019047 B3/4 domain; Region: B3_4; cl11458 216595019048 tRNA synthetase B5 domain; Region: B5; cl08394 216595019049 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 216595019050 dimer interface [polypeptide binding]; other site 216595019051 motif 1; other site 216595019052 motif 3; other site 216595019053 motif 2; other site 216595019054 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 216595019059 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 216595019060 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 216595019061 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 216595019062 dimer interface [polypeptide binding]; other site 216595019063 motif 1; other site 216595019064 active site 216595019065 motif 2; other site 216595019066 motif 3; other site 216595019068 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216595019069 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 216595019071 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 216595019072 23S rRNA binding site [nucleotide binding]; other site 216595019073 L21 binding site [polypeptide binding]; other site 216595019074 L13 binding site [polypeptide binding]; other site 216595019076 PS00937 Ribosomal protein L20 signature. 216595019077 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 216595019079 PS00936 Ribosomal protein L35 signature. 216595019080 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 216595019081 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 216595019082 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 216595019085 PS00938 Initiation factor 3 signature. 216595019086 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 216595019087 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase...; Region: TGS_ThrRS_N; cd01667 216595019088 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 216595019089 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 216595019090 active site 216595019091 dimer interface [polypeptide binding]; other site 216595019092 motif 1; other site 216595019093 motif 2; other site 216595019094 motif 3; other site 216595019095 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 216595019096 anticodon binding site; other site 216595019098 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216595019100 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 216595019103 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 216595019104 DNA-binding site [nucleotide binding]; DNA binding site 216595019105 RNA-binding motif; other site 216595019107 PS00352 'Cold-shock' DNA-binding domain signature. 216595019108 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 216595019109 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595019110 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 216595019111 active site 216595019112 tetramer interface [polypeptide binding]; other site 216595019114 PS01247 Inosine-uridine preferring nucleoside hydrolase family signature. 216595019115 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 216595019117 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 216595019118 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of...; Region: ribokinase; cd01174 216595019119 substrate binding site [chemical binding]; other site 216595019120 dimer interface [polypeptide binding]; other site 216595019121 ATP binding site [chemical binding]; other site 216595019123 PS00017 ATP/GTP-binding site motif A (P-loop). 216595019124 PS00584 pfkB family of carbohydrate kinases signature 2. 216595019125 PS00583 pfkB family of carbohydrate kinases signature 1. 216595019126 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216595019127 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216595019128 DNA binding site [nucleotide binding] 216595019129 domain linker motif; other site 216595019130 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 216595019133 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216595019134 TM-ABC transporter signature motif; other site 216595019135 PS00307 Legume lectins beta-chain signature. 216595019137 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595019138 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 216595019139 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 216595019140 Walker A/P-loop; other site 216595019141 ATP binding site [chemical binding]; other site 216595019142 Q-loop/lid; other site 216595019143 ABC transporter signature motif; other site 216595019144 Walker B; other site 216595019145 D-loop; other site 216595019146 H-loop/switch region; other site 216595019147 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 216595019149 PS00211 ABC transporters family signature. 216595019151 PS00017 ATP/GTP-binding site motif A (P-loop). 216595019152 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 216595019153 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 216595019154 ligand binding site [chemical binding]; other site 216595019156 Asparaginase (amidohydrolase): Asparaginases are tetrameric enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases, one highly specific for asparagine and localised to the...; Region: Asparaginase; cd00411 216595019157 active site/substrate binding site [active] 216595019158 tetramer interface [polypeptide binding]; other site 216595019160 PS00144 Asparaginase / glutaminase active site signature 1. 216595019161 PS00917 Asparaginase / glutaminase active site signature 2. 216595019162 PS00017 ATP/GTP-binding site motif A (P-loop). 216595019163 Protein of unknown function (DUF1654); Region: DUF1654; pfam07867 216595019165 DNA-specific endonuclease I; Provisional; Region: PRK15137 216595019166 Endonuclease I; Region: Endonuclease_1; cl01003 216595019167 1 probable transmembrane helix predicted for PFLU4163 by TMHMM2.0 at aa 13-30 216595019169 PS00017 ATP/GTP-binding site motif A (P-loop). 216595019170 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595019171 Global regulator protein family; Region: CsrA; cl00670 216595019173 2 probable transmembrane helices predicted for PFLU4166 by TMHMM2.0 at aa 13-35 and 45-62 216595019174 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 216595019175 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 216595019176 active site 216595019177 motif I; other site 216595019178 motif II; other site 216595019180 PS01228 Hypothetical cof family signature 1. 216595019181 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216595019182 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595019183 1 probable transmembrane helix predicted for PFLU4169 by TMHMM2.0 at aa 20-42 216595019184 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 216595019185 1 probable transmembrane helix predicted for PFLU4170 by TMHMM2.0 at aa 30-52 216595019186 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 216595019187 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595019188 active site 216595019189 phosphorylation site [posttranslational modification] 216595019190 intermolecular recognition site; other site 216595019191 dimerization interface [polypeptide binding]; other site 216595019192 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 216595019193 DNA binding site [nucleotide binding] 216595019196 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 216595019197 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595019198 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595019199 dimer interface [polypeptide binding]; other site 216595019200 phosphorylation site [posttranslational modification] 216595019201 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595019202 ATP binding site [chemical binding]; other site 216595019203 G-X-G motif; other site 216595019204 2 probable transmembrane helices predicted for PFLU4172 by TMHMM2.0 at aa 10-32 and 169-191 216595019208 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 216595019209 putative substrate binding pocket [chemical binding]; other site 216595019210 AC domain interface; other site 216595019211 catalytic triad [active] 216595019212 AB domain interface; other site 216595019213 interchain disulfide; other site 216595019215 PS01334 Pyrrolidone-carboxylate peptidase cysteine active site. 216595019216 PS01333 Pyrrolidone-carboxylate peptidase glutamic acid active site. 216595019217 Protein of unknown function (DUF979); Region: DUF979; cl01572 216595019219 Protein of unknown function (DUF969); Region: DUF969; cl01573 216595019221 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595019222 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595019223 putative substrate translocation pore; other site 216595019224 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595019225 14 probable transmembrane helices predicted for PFLU4178 by TMHMM2.0 at aa 20-42, 57-79, 86-108, 112-134, 147-169, 173-195, 208-230, 235-254, 282-304, 309-328, 341-363, 368-390, 403-425 and 440-462 216595019227 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595019228 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 216595019229 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 216595019230 PS00043 Bacterial regulatory proteins, gntR family signature. 216595019232 oxidoreductase; Validated; Region: PRK05717 216595019233 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595019234 NAD(P) binding site [chemical binding]; other site 216595019235 active site 216595019237 PS00061 Short-chain dehydrogenases/reductases family signature. 216595019238 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 216595019239 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 216595019240 homodimer interface [polypeptide binding]; other site 216595019241 substrate-cofactor binding pocket; other site 216595019242 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595019243 catalytic residue [active] 216595019245 PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. 216595019246 amidophosphoribosyltransferase; Provisional; Region: PRK09246 216595019247 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 216595019248 active site 216595019249 tetramer interface [polypeptide binding]; other site 216595019250 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 216595019252 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 216595019254 PS00443 Glutamine amidotransferases class-II active site. 216595019255 Colicin V production protein; Region: Colicin_V; cl00567 216595019257 PS00294 Prenyl group binding site (CAAX box). 216595019258 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 216595019259 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 216595019261 PS01011 Folylpolyglutamate synthase signature 1. 216595019262 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 216595019263 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 216595019265 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric...; Region: PRAI; cd00405 216595019266 active site 216595019268 gcgggnnnncccgc 216595019269 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 216595019270 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 216595019271 dimerization interface 3.5A [polypeptide binding]; other site 216595019272 active site 216595019275 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 216595019276 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 216595019277 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 216595019278 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 216595019279 PS01070 DNA/RNA non-specific endonucleases active site. 216595019281 PS00211 ABC transporters family signature. 216595019282 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK05671 216595019283 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595019284 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 216595019287 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 216595019288 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595019289 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 216595019291 PS01103 Aspartate-semialdehyde dehydrogenase signature. 216595019293 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 216595019294 isocitrate dehydrogenase; Validated; Region: PRK06451 216595019296 PS00470 Isocitrate and isopropylmalate dehydrogenases signature. 216595019297 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 216595019298 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 216595019299 S-adenosylmethionine binding site [chemical binding]; other site 216595019301 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577 216595019302 substrate binding site [chemical binding]; other site 216595019304 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 216595019305 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 216595019306 substrate binding site [chemical binding]; other site 216595019307 ligand binding site [chemical binding]; other site 216595019309 PS01244 Aconitase family signature 2. 216595019310 PS00450 Aconitase family signature 1. 216595019311 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595019312 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595019313 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 216595019314 dimerization interface [polypeptide binding]; other site 216595019316 PS00044 Bacterial regulatory proteins, lysR family signature. 216595019318 PAS fold; Region: PAS_3; pfam08447 216595019319 putative diguanylate cyclase; Provisional; Region: PRK09776 216595019320 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 216595019321 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 216595019322 PAS domain S-box; Region: sensory_box; TIGR00229 216595019323 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216595019324 putative active site [active] 216595019325 heme pocket [chemical binding]; other site 216595019326 PAS domain S-box; Region: sensory_box; TIGR00229 216595019327 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 216595019328 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216595019329 metal binding site [ion binding]; metal-binding site 216595019330 active site 216595019331 I-site; other site 216595019332 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216595019340 large tegument protein UL36; Provisional; Region: PHA03247 216595019341 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 216595019342 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 216595019343 FMN binding site [chemical binding]; other site 216595019344 active site 216595019345 catalytic residues [active] 216595019346 substrate binding site [chemical binding]; other site 216595019348 PS01136 Uncharacterized protein family UPF0034 signature. 216595019349 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 216595019350 active site 216595019352 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 216595019353 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595019354 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216595019355 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216595019357 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 216595019358 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 216595019359 active site 216595019360 HIGH motif; other site 216595019361 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 216595019362 active site 216595019363 KMSKS motif; other site 216595019365 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 216595019366 excinuclease ABC subunit B; Provisional; Region: PRK05298 216595019367 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216595019368 ATP binding site [chemical binding]; other site 216595019369 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216595019370 nucleotide binding region [chemical binding]; other site 216595019371 ATP-binding site [chemical binding]; other site 216595019372 Ultra-violet resistance protein B; Region: UvrB; pfam12344 216595019373 UvrB/uvrC motif; Region: UVR; pfam02151 216595019377 PS00017 ATP/GTP-binding site motif A (P-loop). 216595019378 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216595019379 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595019380 homodimer interface [polypeptide binding]; other site 216595019381 catalytic residue [active] 216595019383 PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 216595019384 1 probable transmembrane helix predicted for PFLU4210 by TMHMM2.0 at aa 39-61 216595019385 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595019386 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595019387 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 216595019388 putative dimerization interface [polypeptide binding]; other site 216595019391 PS00044 Bacterial regulatory proteins, lysR family signature. 216595019392 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216595019393 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 216595019394 NAD(P) binding site [chemical binding]; other site 216595019395 catalytic residues [active] 216595019397 PS00070 Aldehyde dehydrogenases cysteine active site. 216595019398 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595019399 LysR family transcriptional regulator; Provisional; Region: PRK14997 216595019400 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 216595019401 putative effector binding pocket; other site 216595019402 putative dimerization interface [polypeptide binding]; other site 216595019405 PS00044 Bacterial regulatory proteins, lysR family signature. 216595019406 putative transporter; Provisional; Region: PRK10054 216595019407 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595019408 putative substrate translocation pore; other site 216595019409 11 probable transmembrane helices predicted for PFLU4214 by TMHMM2.0 at aa 7-29, 44-66, 73-95, 99-116, 146-168, 214-236, 248-270, 280-299, 306-328, 341-363 and 370-392 216595019411 aminopeptidase B; Provisional; Region: PRK05015 216595019412 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 216595019413 active site 216595019414 Zn binding site [ion binding]; other site 216595019417 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 216595019418 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 216595019419 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 216595019420 active site 216595019421 substrate binding site [chemical binding]; other site 216595019422 Mg2+ binding site [ion binding]; other site 216595019424 PS00017 ATP/GTP-binding site motif A (P-loop). 216595019425 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 216595019426 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 216595019427 putative ligand binding residues [chemical binding]; other site 216595019429 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 216595019430 ABC-ATPase subunit interface; other site 216595019431 dimer interface [polypeptide binding]; other site 216595019432 putative PBP binding regions; other site 216595019433 8 probable transmembrane helices predicted for PFLU4220 by TMHMM2.0 at aa 5-27, 57-79, 92-111, 115-137, 149-168, 190-212, 244-266 and 307-329 216595019435 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 216595019436 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 216595019437 Walker A/P-loop; other site 216595019438 ATP binding site [chemical binding]; other site 216595019439 Q-loop/lid; other site 216595019440 ABC transporter signature motif; other site 216595019441 Walker B; other site 216595019442 D-loop; other site 216595019443 H-loop/switch region; other site 216595019445 PS00017 ATP/GTP-binding site motif A (P-loop). 216595019446 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216595019447 Coenzyme A binding pocket [chemical binding]; other site 216595019449 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595019450 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 216595019452 TspO/MBR family; Region: TspO_MBR; cl01379 216595019454 4 probable transmembrane helices predicted for PFLU4229 by TMHMM2.0 at aa 45-67, 93-115, 119-140 and 153-175 216595019456 YeeE/YedE family (DUF395); Region: DUF395; cl01018 216595019457 4 probable transmembrane helices predicted for PFLU4230 by TMHMM2.0 at aa 7-26, 41-63, 84-106 and 111-130 216595019459 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 216595019460 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 216595019461 putative NAD(P) binding site [chemical binding]; other site 216595019464 low G+C content region (47.05%) 216595019465 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 216595019466 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595019467 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 216595019468 dimerization interface [polypeptide binding]; other site 216595019469 substrate binding pocket [chemical binding]; other site 216595019472 PS00044 Bacterial regulatory proteins, lysR family signature. 216595019473 low G+C content region (42.13%) 216595019474 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595019475 putative substrate translocation pore; other site 216595019476 14 probable transmembrane helices predicted for PFLU4234 by TMHMM2.0 at aa 7-29, 44-65, 72-94, 98-120, 133-155, 160-182, 195-214, 219-241, 261-283, 293-312, 325-347, 352-369, 397-419 and 469-491 216595019478 PS00216 Sugar transport proteins signature 1. 216595019479 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 216595019480 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 216595019481 motif II; other site 216595019483 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 216595019484 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595019485 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216595019486 PS00041 Bacterial regulatory proteins, araC family signature. 216595019489 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595019490 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 216595019491 NAD(P) binding site [chemical binding]; other site 216595019492 active site 216595019494 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 216595019496 Uncharacterized conserved protein [Function unknown]; Region: COG3268 216595019498 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 216595019499 dimer interface [polypeptide binding]; other site 216595019500 ligand binding site [chemical binding]; other site 216595019501 PS00017 ATP/GTP-binding site motif A (P-loop). 216595019502 Protein of unknown function DUF262; Region: DUF262; cl14890 216595019503 Uncharacterized conserved protein (DUF2081); Region: DUF2081; cl09179 216595019505 PS00146 Beta-lactamase class-A active site. 216595019506 LysE type translocator; Region: LysE; cl00565 216595019508 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595019509 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595019510 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595019511 dimerization interface [polypeptide binding]; other site 216595019513 PS00044 Bacterial regulatory proteins, lysR family signature. 216595019515 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 216595019517 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 216595019518 Uncharacterized conserved protein [Function unknown]; Region: COG4285 216595019519 conserved cys residue [active] 216595019520 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 216595019521 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins...; Region: GST_N_GTT1_like; cd03046 216595019522 putative C-terminal domain interface [polypeptide binding]; other site 216595019523 putative GSH binding site (G-site) [chemical binding]; other site 216595019524 putative dimer interface [polypeptide binding]; other site 216595019525 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 216595019526 putative N-terminal domain interface [polypeptide binding]; other site 216595019527 putative dimer interface [polypeptide binding]; other site 216595019528 putative substrate binding pocket (H-site) [chemical binding]; other site 216595019531 PS00017 ATP/GTP-binding site motif A (P-loop). 216595019532 OPT oligopeptide transporter protein; Region: OPT; cl14607 216595019534 Transposase IS200 like; Region: Y1_Tnp; cl00848 216595019536 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 216595019537 1 probable transmembrane helix predicted for PFLU4256 by TMHMM2.0 at aa 17-39 216595019538 PS00017 ATP/GTP-binding site motif A (P-loop). 216595019539 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595019542 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 216595019544 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216595019545 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595019546 DNA-binding site [nucleotide binding]; DNA binding site 216595019547 FCD domain; Region: FCD; cl11656 216595019550 low G+C content region (40.15%) 216595019551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595019552 D-galactonate transporter; Region: 2A0114; TIGR00893 216595019553 putative substrate translocation pore; other site 216595019554 12 probable transmembrane helices predicted for PFLU4260 by TMHMM2.0 at aa 27-49, 59-81, 93-112, 118-140, 153-175, 185-207, 255-277, 292-314, 321-340, 344-366, 373-395 and 410-429 216595019556 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 216595019557 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of...; Region: D-glucarate_dehydratase; cd03323 216595019558 active site 216595019559 tetramer interface [polypeptide binding]; other site 216595019562 PS00294 Prenyl group binding site (CAAX box). 216595019563 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 216595019564 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 216595019565 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595019566 membrane-bound complex binding site; other site 216595019568 low G+C content region (44.97%) 216595019569 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 216595019570 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216595019571 active site 216595019573 acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892 216595019574 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 216595019575 metal binding site [ion binding]; metal-binding site 216595019576 putative dimer interface [polypeptide binding]; other site 216595019579 PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2. 216595019580 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 216595019582 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 216595019583 intersubunit interface [polypeptide binding]; other site 216595019584 active site 216595019585 Zn2+ binding site [ion binding]; other site 216595019587 PS00017 ATP/GTP-binding site motif A (P-loop). 216595019588 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595019589 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216595019590 substrate binding pocket [chemical binding]; other site 216595019591 membrane-bound complex binding site; other site 216595019592 hinge residues; other site 216595019594 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 216595019595 1 probable transmembrane helix predicted for PFLU4268 by TMHMM2.0 at aa 7-29 216595019596 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 216595019598 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216595019599 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595019600 dimer interface [polypeptide binding]; other site 216595019601 conserved gate region; other site 216595019602 putative PBP binding loops; other site 216595019603 ABC-ATPase subunit interface; other site 216595019604 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 216595019605 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 216595019606 Walker A/P-loop; other site 216595019607 ATP binding site [chemical binding]; other site 216595019608 Q-loop/lid; other site 216595019609 ABC transporter signature motif; other site 216595019610 Walker B; other site 216595019611 D-loop; other site 216595019612 H-loop/switch region; other site 216595019614 PS00211 ABC transporters family signature. 216595019615 PS00017 ATP/GTP-binding site motif A (P-loop). 216595019617 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595019618 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595019619 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 216595019620 putative substrate binding pocket [chemical binding]; other site 216595019621 dimerization interface [polypeptide binding]; other site 216595019624 PS00044 Bacterial regulatory proteins, lysR family signature. 216595019625 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 216595019626 homotrimer interaction site [polypeptide binding]; other site 216595019627 putative active site [active] 216595019629 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 216595019630 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 216595019631 NAD(P) binding site [chemical binding]; other site 216595019634 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 216595019635 trimer interface [polypeptide binding]; other site 216595019636 active site 216595019637 dimer interface [polypeptide binding]; other site 216595019639 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 216595019640 FIST N domain; Region: FIST; cl10701 216595019641 FIST C domain; Region: FIST_C; pfam10442 216595019642 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595019643 PS00017 ATP/GTP-binding site motif A (P-loop). 216595019645 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 216595019647 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 216595019648 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595019649 low G+C content region (47.02%) 216595019650 putative inner membrane protein; Provisional; Region: PRK11099 216595019651 YeeE/YedE family (DUF395); Region: DUF395; cl01018 216595019652 putative inner membrane protein; Provisional; Region: PRK11099 216595019655 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595019656 H+ Antiporter protein; Region: 2A0121; TIGR00900 216595019657 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595019658 putative substrate translocation pore; other site 216595019659 10 probable transmembrane helices predicted for PFLU4281 by TMHMM2.0 at aa 13-35, 50-72, 84-106, 172-194, 227-249, 259-281, 288-307, 312-334, 347-369 and 373-395 216595019661 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 216595019662 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 216595019663 active site 216595019664 substrate binding site [chemical binding]; other site 216595019665 Mg2+ binding site [ion binding]; other site 216595019667 PS01070 DNA/RNA non-specific endonucleases active site. 216595019668 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 216595019669 NAD(P) binding site [chemical binding]; other site 216595019670 active site 216595019672 PS00904 Protein prenyltransferases alpha subunit repeat signature. 216595019673 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 216595019674 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595019675 dimer interface [polypeptide binding]; other site 216595019676 phosphorylation site [posttranslational modification] 216595019677 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595019678 ATP binding site [chemical binding]; other site 216595019679 Mg2+ binding site [ion binding]; other site 216595019680 G-X-G motif; other site 216595019682 PS00017 ATP/GTP-binding site motif A (P-loop). 216595019684 circadian clock protein KaiC; Reviewed; Region: PRK09302 216595019685 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595019686 Walker A motif; other site 216595019687 ATP binding site [chemical binding]; other site 216595019688 Walker B motif; other site 216595019689 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595019690 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595019691 Walker A motif; other site 216595019692 Walker A motif; other site 216595019693 ATP binding site [chemical binding]; other site 216595019694 Walker B motif; other site 216595019696 PS00017 ATP/GTP-binding site motif A (P-loop). 216595019697 PS00017 ATP/GTP-binding site motif A (P-loop). 216595019698 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 216595019699 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595019700 putative substrate translocation pore; other site 216595019702 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216595019703 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216595019705 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595019706 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595019707 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 216595019708 dimerization interface [polypeptide binding]; other site 216595019711 PS00044 Bacterial regulatory proteins, lysR family signature. 216595019712 hypothetical protein; Validated; Region: PRK06201 216595019713 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 216595019715 hypothetical protein; Validated; Region: PRK07682 216595019716 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216595019717 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595019718 homodimer interface [polypeptide binding]; other site 216595019719 catalytic residue [active] 216595019721 PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 216595019722 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 216595019723 8 probable transmembrane helices predicted for PFLU4294 by TMHMM2.0 at aa 7-29, 49-71, 84-106, 150-172, 192-214, 229-251, 306-328 and 358-380 216595019725 PS00713 Sodium:dicarboxylate symporter family signature 1. 216595019726 PS00017 ATP/GTP-binding site motif A (P-loop). 216595019727 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 216595019728 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein...; Region: ACD_IbpA-B_like; cd06470 216595019729 putative dimer interface [polypeptide binding]; other site 216595019735 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595019736 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595019737 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 216595019738 putative dimerization interface [polypeptide binding]; other site 216595019741 PS00044 Bacterial regulatory proteins, lysR family signature. 216595019742 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 216595019743 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 216595019744 active site 216595019745 substrate binding site [chemical binding]; other site 216595019746 FMN binding site [chemical binding]; other site 216595019747 putative catalytic residues [active] 216595019749 PS00557 FMN-dependent alpha-hydroxy acid dehydrogenases active site. 216595019750 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216595019751 metal binding site [ion binding]; metal-binding site 216595019752 active site 216595019753 I-site; other site 216595019755 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 216595019757 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 216595019758 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 216595019759 PAS fold; Region: PAS; pfam00989 216595019760 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216595019761 metal binding site [ion binding]; metal-binding site 216595019762 active site 216595019763 I-site; other site 216595019764 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216595019768 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 216595019769 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 216595019770 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595019771 Walker A/P-loop; other site 216595019772 ATP binding site [chemical binding]; other site 216595019773 Q-loop/lid; other site 216595019774 ABC transporter signature motif; other site 216595019775 Walker B; other site 216595019776 D-loop; other site 216595019777 H-loop/switch region; other site 216595019779 PS00211 ABC transporters family signature. 216595019780 PS00017 ATP/GTP-binding site motif A (P-loop). 216595019782 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 216595019783 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 216595019784 catalytic residues [active] 216595019785 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 216595019786 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 216595019787 active site residue [active] 216595019789 BolA-like protein; Region: BolA; cl00386 216595019791 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 216595019792 fumarate hydratase; Provisional; Region: PRK12425 216595019793 Class II fumarases; Region: Fumarase_classII; cd01362 216595019794 active site 216595019795 tetramer interface [polypeptide binding]; other site 216595019797 PS00017 ATP/GTP-binding site motif A (P-loop). 216595019798 PS00163 Fumarate lyases signature. 216595019799 EamA-like transporter family; Region: EamA; cl01037 216595019800 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 216595019803 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 216595019804 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 216595019805 dimer interface [polypeptide binding]; other site 216595019806 active site 216595019808 PS00737 Thiolases signature 2. 216595019810 PS00098 Thiolases acyl-enzyme intermediate signature. 216595019811 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 216595019812 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 216595019813 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 216595019816 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 216595019817 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 216595019818 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 216595019821 E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387 216595019822 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl15309 216595019824 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 216595019825 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 216595019826 active site 216595019827 dimer interface [polypeptide binding]; other site 216595019828 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 216595019829 Ligand Binding Site [chemical binding]; other site 216595019830 Molecular Tunnel; other site 216595019833 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 216595019834 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 216595019835 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 216595019838 hydrolase, peptidase M42 family; Region: trio_M42_hydro; TIGR03106 216595019839 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 216595019840 putative oligomer interface [polypeptide binding]; other site 216595019841 putative active site [active] 216595019842 metal binding site [ion binding]; metal-binding site 216595019844 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 216595019845 Uncharacterised protein family (UPF0270); Region: UPF0270; cl01180 216595019847 Global regulator protein family; Region: CsrA; cl00670 216595019849 short chain dehydrogenase; Provisional; Region: PRK05650 216595019850 classical (c) SDRs; Region: SDR_c; cd05233 216595019851 NAD(P) binding site [chemical binding]; other site 216595019852 active site 216595019854 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 216595019855 2 probable transmembrane helices predicted for PFLU4326 by TMHMM2.0 at aa 2-21 and 26-48 216595019856 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 216595019857 Sulfatase; Region: Sulfatase; cl10460 216595019859 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 216595019860 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 216595019864 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 216595019865 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595019867 PS00455 Putative AMP-binding domain signature. 216595019868 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 216595019869 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 216595019870 DNA binding residues [nucleotide binding] 216595019871 dimerization interface [polypeptide binding]; other site 216595019873 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 216595019875 MFS_1 like family; Region: MFS_1_like; pfam12832 216595019876 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595019877 putative substrate translocation pore; other site 216595019878 PS00044 Bacterial regulatory proteins, lysR family signature. 216595019880 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 216595019881 Tetramer interface [polypeptide binding]; other site 216595019882 Active site [active] 216595019883 FMN-binding site [chemical binding]; other site 216595019885 PS00789 Chorismate synthase signature 3. 216595019886 PS00788 Chorismate synthase signature 2. 216595019887 PS00787 Chorismate synthase signature 1. 216595019888 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216595019889 PS00120 Lipases, serine active site. 216595019890 1 probable transmembrane helix predicted for PFLU4340 by TMHMM2.0 at aa 272-294 216595019891 HemK family putative methylases; Region: hemK_fam; TIGR00536 216595019892 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 216595019893 S-adenosylmethionine binding site [chemical binding]; other site 216595019895 PS00092 N-6 Adenine-specific DNA methylases signature. 216595019896 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595019897 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 216595019898 Isochorismatase family; Region: Isochorismatase; pfam00857 216595019899 catalytic triad [active] 216595019900 conserved cis-peptide bond; other site 216595019902 2 probable transmembrane helices predicted for PFLU4343 by TMHMM2.0 at aa 20-42 and 62-81 216595019903 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 216595019904 Smr domain; Region: Smr; cl02619 216595019906 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 216595019907 homodecamer interface [polypeptide binding]; other site 216595019908 GTP cyclohydrolase I; Provisional; Region: PLN03044 216595019909 active site 216595019910 putative catalytic site residues [active] 216595019911 zinc binding site [ion binding]; other site 216595019912 GTP-CH-I/GFRP interaction surface; other site 216595019914 PS00859 GTP cyclohydrolase I signature 1. 216595019915 PS00860 GTP cyclohydrolase I signature 2. 216595019916 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 216595019918 PS00195 Glutaredoxin active site. 216595019919 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 216595019920 Integrase core domain; Region: rve; cl01316 216595019922 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 216595019924 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 216595019925 Citrate transporter; Region: CitMHS; pfam03600 216595019927 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595019928 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 216595019929 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 216595019930 putative dimerization interface [polypeptide binding]; other site 216595019932 PS00044 Bacterial regulatory proteins, lysR family signature. 216595019934 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 216595019935 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 216595019936 putative C-terminal domain interface [polypeptide binding]; other site 216595019937 putative GSH binding site (G-site) [chemical binding]; other site 216595019938 putative dimer interface [polypeptide binding]; other site 216595019939 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 216595019940 N-terminal domain interface [polypeptide binding]; other site 216595019941 dimer interface [polypeptide binding]; other site 216595019942 substrate binding pocket (H-site) [chemical binding]; other site 216595019945 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216595019946 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595019947 homodimer interface [polypeptide binding]; other site 216595019948 catalytic residue [active] 216595019950 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595019952 Sulfate transporter family; Region: Sulfate_transp; cl00967 216595019953 Permease family; Region: Xan_ur_permease; pfam00860 216595019955 11 probable transmembrane helices predicted for PFLU4355 by TMHMM2.0 at aa 38-60, 70-92, 113-135, 150-172, 184-206, 210-232, 253-272, 330-352, 359-381, 396-418 and 430-447 216595019956 LysE type translocator; Region: LysE; cl00565 216595019957 5 probable transmembrane helices predicted for PFLU4356 by TMHMM2.0 at aa 15-37, 49-71, 81-98, 125-147 and 162-184 216595019959 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU)...; Region: TLP_HIUase; cd05822 216595019960 active site 216595019961 homotetramer interface [polypeptide binding]; other site 216595019963 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 216595019964 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 216595019966 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 216595019967 allantoicase; Provisional; Region: PRK13257 216595019968 Allantoicase repeat; Region: Allantoicase; pfam03561 216595019969 Allantoicase repeat; Region: Allantoicase; pfam03561 216595019972 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 216595019973 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 216595019975 Predicted membrane protein [Function unknown]; Region: COG3748 216595019976 Protein of unknown function (DUF989); Region: DUF989; pfam06181 216595019977 Cytochrome c; Region: Cytochrom_C; cl11414 216595019979 8 probable transmembrane helices predicted for PFLU4363 by TMHMM2.0 at aa 15-34, 81-103, 118-137, 146-163, 173-192, 223-240, 250-267 and 276-295 216595019980 PS00190 Cytochrome c family heme-binding site signature. 216595019981 Sulfate transporter family; Region: Sulfate_transp; cl00967 216595019982 Permease family; Region: Xan_ur_permease; pfam00860 216595019984 11 probable transmembrane helices predicted for PFLU4364 by TMHMM2.0 at aa 23-45, 57-79, 108-130, 137-159, 169-191, 198-220, 249-271, 325-347, 351-373, 385-404 and 414-436 216595019985 PS01116 Xanthine/uracil permeases family signature. 216595019986 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 216595019987 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 216595019988 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 216595019989 active site 216595019990 nucleophile elbow; other site 216595019992 lipid A biosynthesis lauroyl acyltransferase; Provisional; Region: PRK05906 216595019993 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 216595019994 putative acyl-acceptor binding pocket; other site 216595019996 1 probable transmembrane helix predicted for PFLU4368 by TMHMM2.0 at aa 22-44 216595019997 septum formation inhibitor; Reviewed; Region: minC; PRK00339 216595019998 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 216595019999 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 216595020002 cell division inhibitor MinD; Provisional; Region: PRK10818 216595020003 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a...; Region: MinD; cd02036 216595020004 Switch I; other site 216595020005 Switch II; other site 216595020007 PS00017 ATP/GTP-binding site motif A (P-loop). 216595020008 Septum formation topological specificity factor MinE; Region: MinE; cl00538 216595020010 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 216595020011 active site 216595020013 PS01129 Rlu family of pseudouridine synthase signature. 216595020014 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 216595020015 active site 216595020016 metal binding site [ion binding]; metal-binding site 216595020018 2 probable transmembrane helices predicted for PFLU4374 by TMHMM2.0 at aa 5-27 and 32-54 216595020019 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 216595020020 Mechanosensitive ion channel; Region: MS_channel; pfam00924 216595020021 12 probable transmembrane helices predicted for PFLU4375 by TMHMM2.0 at aa 5-27, 139-161, 186-208, 218-240, 261-283, 288-310, 335-357, 367-389, 414-436, 456-478, 499-521 and 531-553 216595020023 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667 216595020024 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 216595020025 metal binding site [ion binding]; metal-binding site 216595020026 putative dimer interface [polypeptide binding]; other site 216595020029 MbtH-like protein; Region: MbtH; cl01279 216595020031 PS00017 ATP/GTP-binding site motif A (P-loop). 216595020032 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 216595020033 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 216595020034 inhibitor-cofactor binding pocket; inhibition site 216595020035 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595020036 catalytic residue [active] 216595020038 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 216595020040 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 216595020041 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 216595020042 amidase catalytic site [active] 216595020043 Zn binding residues [ion binding]; other site 216595020044 substrate binding site [chemical binding]; other site 216595020046 sensor protein QseC; Provisional; Region: PRK10337 216595020047 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 216595020048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595020049 ATP binding site [chemical binding]; other site 216595020050 G-X-G motif; other site 216595020054 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595020055 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 216595020056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595020057 active site 216595020058 phosphorylation site [posttranslational modification] 216595020059 intermolecular recognition site; other site 216595020060 dimerization interface [polypeptide binding]; other site 216595020061 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 216595020062 DNA binding site [nucleotide binding] 216595020065 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 216595020066 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 216595020067 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 216595020068 DsbD alpha interface [polypeptide binding]; other site 216595020069 catalytic residues [active] 216595020071 8 probable transmembrane helices predicted for PFLU4382 by TMHMM2.0 at aa 169-191, 203-225, 235-257, 277-299, 319-341, 354-376, 380-399 and 408-430 216595020073 PS00194 Thioredoxin family active site. 216595020074 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 216595020075 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 216595020076 catalytic residues [active] 216595020077 4 probable transmembrane helices predicted for PFLU4383 by TMHMM2.0 at aa 10-32, 45-67, 82-101 and 108-130 216595020079 PS00194 Thioredoxin family active site. 216595020080 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 216595020081 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide...; Region: DsbA_DsbC_DsbG; cd03020 216595020082 dimerization domain [polypeptide binding]; other site 216595020083 dimer interface [polypeptide binding]; other site 216595020084 catalytic residues [active] 216595020085 peptide synthase; Validated; Region: PRK05691 216595020086 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595020087 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595020088 Phosphopantetheine attachment site; Region: PP-binding; cl09936 216595020089 Condensation domain; Region: Condensation; cl09290 216595020090 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595020091 Phosphopantetheine attachment site; Region: PP-binding; cl09936 216595020092 Condensation domain; Region: Condensation; cl09290 216595020093 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595020094 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595020095 Phosphopantetheine attachment site; Region: PP-binding; cl09936 216595020096 Condensation domain; Region: Condensation; cl09290 216595020097 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 216595020098 Condensation domain; Region: Condensation; cl09290 216595020099 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595020100 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595020101 Phosphopantetheine attachment site; Region: PP-binding; cl09936 216595020102 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 216595020103 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 216595020104 nucleophilic elbow; other site 216595020105 catalytic triad; other site 216595020107 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 216595020108 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216595020109 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 216595020112 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 216595020113 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595020114 substrate binding pocket [chemical binding]; other site 216595020115 membrane-bound complex binding site; other site 216595020116 hinge residues; other site 216595020117 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216595020118 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216595020120 PS01081 Bacterial regulatory proteins, tetR family signature. 216595020121 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 216595020123 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216595020124 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 216595020125 NAD(P) binding site [chemical binding]; other site 216595020126 substrate binding site [chemical binding]; other site 216595020127 homotetramer interface [polypeptide binding]; other site 216595020128 active site 216595020129 homodimer interface [polypeptide binding]; other site 216595020131 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 216595020132 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 216595020133 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 216595020135 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216595020136 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216595020137 active site 216595020140 PS00072 Acyl-CoA dehydrogenases signature 1. 216595020142 PS00073 Acyl-CoA dehydrogenases signature 2. 216595020143 enoyl-CoA hydratase; Provisional; Region: PRK05995 216595020144 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 216595020145 substrate binding site [chemical binding]; other site 216595020146 oxyanion hole (OAH) forming residues; other site 216595020147 trimer interface [polypeptide binding]; other site 216595020149 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 216595020150 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 216595020151 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 216595020152 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 216595020153 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 216595020154 carboxyltransferase (CT) interaction site; other site 216595020155 biotinylation site [posttranslational modification]; other site 216595020158 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 216595020159 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 216595020161 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 216595020163 PS00188 Biotin-requiring enzymes attachment site. 216595020164 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 216595020165 active site 216595020166 substrate binding site [chemical binding]; other site 216595020167 catalytic site [active] 216595020169 Protein of unknown function (DUF1255); Region: DUF1255; cl01202 216595020171 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 216595020172 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 216595020173 MOSC domain; Region: MOSC; pfam03473 216595020176 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 216595020177 Response regulator receiver domain; Region: Response_reg; pfam00072 216595020178 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595020179 active site 216595020180 phosphorylation site [posttranslational modification] 216595020181 intermolecular recognition site; other site 216595020182 dimerization interface [polypeptide binding]; other site 216595020185 low G+C content region (41.84%) 216595020186 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 216595020187 Histidine kinase; Region: HisKA_3; pfam07730 216595020188 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595020189 ATP binding site [chemical binding]; other site 216595020190 Mg2+ binding site [ion binding]; other site 216595020191 G-X-G motif; other site 216595020192 2 probable transmembrane helices predicted for PFLU4403 by TMHMM2.0 at aa 53-70 and 75-92 216595020195 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216595020196 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595020197 active site 216595020198 phosphorylation site [posttranslational modification] 216595020199 intermolecular recognition site; other site 216595020200 dimerization interface [polypeptide binding]; other site 216595020201 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 216595020202 DNA binding residues [nucleotide binding] 216595020203 dimerization interface [polypeptide binding]; other site 216595020206 lipid kinase; Reviewed; Region: PRK13054 216595020207 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 216595020209 Protein of unknown function (DUF2802); Region: DUF2802; pfam10975 216595020210 1 probable transmembrane helix predicted for PFLU4406 by TMHMM2.0 at aa 5-22 216595020211 chemotaxis gene cluster 216595020212 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 216595020213 putative CheA interaction surface; other site 216595020215 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 216595020217 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 216595020218 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 216595020219 P-loop; other site 216595020220 Magnesium ion binding site [ion binding]; other site 216595020221 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 216595020222 Magnesium ion binding site [ion binding]; other site 216595020224 flagellar motor protein MotD; Reviewed; Region: PRK09038 216595020225 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216595020226 ligand binding site [chemical binding]; other site 216595020228 1 probable transmembrane helix predicted for PFLU4410 by TMHMM2.0 at aa 19-41 216595020229 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 216595020230 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 216595020232 PS00622 Bacterial regulatory proteins, luxR family signature. 216595020233 Response regulator receiver domain; Region: Response_reg; pfam00072 216595020234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595020235 active site 216595020236 phosphorylation site [posttranslational modification] 216595020237 intermolecular recognition site; other site 216595020238 dimerization interface [polypeptide binding]; other site 216595020239 CheB methylesterase; Region: CheB_methylest; pfam01339 216595020242 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 216595020243 putative binding surface; other site 216595020244 active site 216595020245 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 216595020246 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595020247 ATP binding site [chemical binding]; other site 216595020248 Mg2+ binding site [ion binding]; other site 216595020249 G-X-G motif; other site 216595020250 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 216595020252 PS00018 EF-hand calcium-binding domain. 216595020256 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 216595020258 Response regulator receiver domain; Region: Response_reg; pfam00072 216595020259 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595020260 active site 216595020261 phosphorylation site [posttranslational modification] 216595020262 intermolecular recognition site; other site 216595020263 dimerization interface [polypeptide binding]; other site 216595020265 flagella biosynthesis gene cluster 216595020266 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 216595020267 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216595020268 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 216595020269 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 216595020270 DNA binding residues [nucleotide binding] 216595020274 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 216595020275 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 216595020276 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 216595020278 PS00017 ATP/GTP-binding site motif A (P-loop). 216595020279 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 216595020280 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 216595020282 PS00017 ATP/GTP-binding site motif A (P-loop). 216595020283 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 216595020284 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 216595020286 PS00994 Bacterial export FHIPEP family signature. 216595020287 low G+C content region (51.91%) 216595020288 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017 216595020289 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 216595020291 PS00678 Trp-Asp (WD) repeats signature. 216595020292 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 216595020293 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 216595020295 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 216595020297 FliP family; Region: FliP; cl00593 216595020299 PS01061 Flagella transport protein fliP family signature 2. 216595020300 PS01060 Flagella transport protein fliP family signature 1. 216595020301 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 216595020303 1 probable transmembrane helix predicted for PFLU4426 by TMHMM2.0 at aa 38-60 216595020304 flagellar motor switch protein; Validated; Region: fliN; PRK05698 216595020305 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 216595020307 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 216595020308 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 216595020311 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 216595020313 1 probable transmembrane helix predicted for PFLU4429 by TMHMM2.0 at aa 20-42 216595020314 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 216595020316 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 216595020317 putative binding surface; other site 216595020318 active site 216595020320 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595020321 Response regulator receiver domain; Region: Response_reg; pfam00072 216595020322 active site 216595020323 phosphorylation site [posttranslational modification] 216595020324 intermolecular recognition site; other site 216595020325 dimerization interface [polypeptide binding]; other site 216595020326 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 216595020327 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 216595020331 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 216595020332 anti sigma factor interaction site; other site 216595020333 regulatory phosphorylation site [posttranslational modification]; other site 216595020335 Flagellar FliJ protein; Region: FliJ; cl09161 216595020336 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 216595020337 flagellum-specific ATP synthase; Validated; Region: fliI; PRK05688 216595020338 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 216595020339 Walker A motif/ATP binding site; other site 216595020340 Walker B motif; other site 216595020342 PS00152 ATP synthase alpha and beta subunits signature. 216595020343 PS00017 ATP/GTP-binding site motif A (P-loop). 216595020344 flagellar assembly protein H; Validated; Region: fliH; PRK05687 216595020345 Flagellar assembly protein FliH; Region: FliH; pfam02108 216595020347 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216595020348 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 216595020349 MgtE intracellular N domain; Region: MgtE_N; cl15244 216595020350 FliG C-terminal domain; Region: FliG_C; pfam01706 216595020352 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 216595020353 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 216595020354 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 216595020357 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 216595020359 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 216595020360 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595020361 active site 216595020362 phosphorylation site [posttranslational modification] 216595020363 intermolecular recognition site; other site 216595020364 dimerization interface [polypeptide binding]; other site 216595020365 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595020366 Walker A motif; other site 216595020367 ATP binding site [chemical binding]; other site 216595020368 Walker B motif; other site 216595020369 arginine finger; other site 216595020370 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 216595020372 PS00688 Sigma-54 interaction domain C-terminal part signature. 216595020374 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 216595020375 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 216595020377 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 216595020378 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216595020379 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595020380 dimer interface [polypeptide binding]; other site 216595020381 phosphorylation site [posttranslational modification] 216595020382 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595020383 ATP binding site [chemical binding]; other site 216595020384 Mg2+ binding site [ion binding]; other site 216595020385 G-X-G motif; other site 216595020389 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 216595020390 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 216595020391 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595020392 Walker A motif; other site 216595020393 ATP binding site [chemical binding]; other site 216595020394 Walker B motif; other site 216595020395 arginine finger; other site 216595020396 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 216595020398 PS00688 Sigma-54 interaction domain C-terminal part signature. 216595020400 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 216595020401 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 216595020403 Flagellar protein FliS; Region: FliS; cl00654 216595020405 flagellar capping protein; Reviewed; Region: fliD; PRK08032 216595020406 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 216595020407 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 216595020411 FlaG protein; Region: FlaG; cl00591 216595020413 flagellin; Provisional; Region: PRK12806 216595020414 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 216595020415 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 216595020420 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 216595020421 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 216595020422 dimer interface [polypeptide binding]; other site 216595020423 active site 216595020424 CoA binding pocket [chemical binding]; other site 216595020427 PS00017 ATP/GTP-binding site motif A (P-loop). 216595020428 flagellar hook-associated protein FlgL; Provisional; Region: flgL; PRK12717 216595020429 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 216595020430 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 216595020432 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK05683 216595020433 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 216595020434 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 216595020437 PS00588 Flagella basal body rod proteins signature. 216595020438 Rod binding protein; Region: Rod-binding; cl01626 216595020439 flagellar rod assembly protein/muramidase FlgJ; Provisional; Region: flgJ; PRK12713 216595020440 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 216595020442 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 216595020443 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 216595020445 Flagellar L-ring protein; Region: FlgH; cl00905 216595020447 PS00017 ATP/GTP-binding site motif A (P-loop). 216595020448 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595020449 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 216595020450 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 216595020451 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 216595020454 PS00588 Flagella basal body rod proteins signature. 216595020455 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 216595020456 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 216595020457 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 216595020459 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 216595020460 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 216595020461 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 216595020462 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595020463 Walker A motif; other site 216595020464 ATP binding site [chemical binding]; other site 216595020465 Walker B motif; other site 216595020466 arginine finger; other site 216595020467 PS00688 Sigma-54 interaction domain C-terminal part signature. 216595020469 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 216595020471 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH)...; Region: pro_PheOH; cd03348 216595020472 cofactor binding site; other site 216595020473 metal binding site [ion binding]; metal-binding site 216595020475 PS00367 Biopterin-dependent aromatic amino acid hydroxylases signature. 216595020476 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 216595020477 aromatic arch; other site 216595020478 DCoH dimer interaction site [polypeptide binding]; other site 216595020479 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 216595020480 DCoH tetramer interaction site [polypeptide binding]; other site 216595020481 substrate binding site [chemical binding]; other site 216595020483 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216595020484 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595020485 homodimer interface [polypeptide binding]; other site 216595020486 catalytic residue [active] 216595020488 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 216595020489 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 216595020490 putative active site [active] 216595020491 putative metal binding site [ion binding]; other site 216595020493 Cupin domain; Region: Cupin_2; cl09118 216595020494 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216595020495 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595020498 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 216595020499 EamA-like transporter family; Region: EamA; cl01037 216595020500 10 probable transmembrane helices predicted for PFLU4463 by TMHMM2.0 at aa 7-29, 33-55, 68-87, 92-114, 121-138, 148-165, 177-199, 209-231, 238-257 and 262-284 216595020503 PS00089 Ribonucleotide reductase large subunit signature. 216595020504 PS00626 Regulator of chromosome condensation (RCC1) signature 2. 216595020505 3 probable transmembrane helices predicted for PFLU4464 by TMHMM2.0 at aa 10-32, 44-66 and 76-98 216595020506 Rdx family; Region: Rdx; cl01407 216595020508 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 216595020509 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 216595020510 active site 216595020511 nucleophile elbow; other site 216595020512 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 216595020513 Surface antigen; Region: Bac_surface_Ag; cl03097 216595020517 Transcriptional regulators [Transcription]; Region: MarR; COG1846 216595020518 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595020520 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 216595020521 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216595020522 ATP binding site [chemical binding]; other site 216595020523 putative Mg++ binding site [ion binding]; other site 216595020524 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216595020525 nucleotide binding region [chemical binding]; other site 216595020526 ATP-binding site [chemical binding]; other site 216595020527 RQC domain; Region: RQC; cl09632 216595020528 HRDC domain; Region: HRDC; cl02578 216595020532 Uncharacterised protein family (UPF0149); Region: UPF0149; cl01173 216595020533 Protein of unknown function (DUF454); Region: DUF454; cl01063 216595020534 2 probable transmembrane helices predicted for PFLU4470 by TMHMM2.0 at aa 12-34 and 86-108 216595020536 Sodium:solute symporter family; Region: SSF; cl00456 216595020537 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 216595020538 PAS fold; Region: PAS_7; pfam12860 216595020539 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216595020540 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 216595020541 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595020542 ATP binding site [chemical binding]; other site 216595020543 Mg2+ binding site [ion binding]; other site 216595020544 G-X-G motif; other site 216595020545 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 216595020546 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595020547 active site 216595020548 phosphorylation site [posttranslational modification] 216595020549 intermolecular recognition site; other site 216595020550 dimerization interface [polypeptide binding]; other site 216595020551 12 probable transmembrane helices predicted for PFLU4471 by TMHMM2.0 at aa 4-26, 39-61, 65-87, 115-134, 161-178, 191-213, 247-266, 279-301, 329-351, 382-401, 411-433 and 440-462 216595020556 RmuC family; Region: RmuC; pfam02646 216595020558 1 probable transmembrane helix predicted for PFLU4472 by TMHMM2.0 at aa 13-32 216595020559 3 probable transmembrane helices predicted for PFLU4474 by TMHMM2.0 at aa 36-58, 63-85 and 106-128 216595020560 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 216595020561 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl09488 216595020563 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340 216595020564 catalytic residues [active] 216595020565 dimer interface [polypeptide binding]; other site 216595020567 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595020568 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 216595020569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595020571 Transcriptional regulators [Transcription]; Region: MarR; COG1846 216595020572 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595020574 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 216595020576 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595020577 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 216595020578 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 216595020579 catalytic core [active] 216595020581 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 216595020582 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 216595020583 putative dimer interface [polypeptide binding]; other site 216595020584 active site pocket [active] 216595020585 putative cataytic base [active] 216595020587 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595020588 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is...; Region: CobU; cd00544 216595020589 homotrimer interface [polypeptide binding]; other site 216595020590 Walker A motif; other site 216595020591 GTP binding site [chemical binding]; other site 216595020592 Walker B motif; other site 216595020594 PS00017 ATP/GTP-binding site motif A (P-loop). 216595020595 gcgggnnnncccgc 216595020596 gcgggnnnncccgc 216595020597 gcgggnnnncccgc 216595020598 gcgggnnnncccgc 216595020599 cobyric acid synthase; Provisional; Region: PRK00784 216595020600 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 216595020601 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 216595020602 catalytic triad [active] 216595020605 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 216595020606 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216595020607 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595020608 homodimer interface [polypeptide binding]; other site 216595020609 catalytic residue [active] 216595020611 PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 216595020612 CobD/Cbib protein; Region: CobD_Cbib; cl00561 216595020614 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 216595020615 FMN binding site [chemical binding]; other site 216595020616 dimer interface [polypeptide binding]; other site 216595020618 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 216595020619 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 216595020620 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 216595020621 catalytic triad [active] 216595020624 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595020625 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 216595020626 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a...; Region: CobA_CobO_BtuR; cd00561 216595020627 Walker A motif; other site 216595020628 homodimer interface [polypeptide binding]; other site 216595020629 ATP binding site [chemical binding]; other site 216595020630 hydroxycobalamin binding site [chemical binding]; other site 216595020631 Walker B motif; other site 216595020633 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 216595020634 Membrane bound L-sorbosone dehydrogenase; Region: SNDH; pfam12303 216595020635 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595020638 PS00133 Zinc carboxypeptidases, zinc-binding region 2 signature. 216595020640 NlpC/P60 family; Region: NLPC_P60; cl11438 216595020642 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595020643 NlpC/P60 family; Region: NLPC_P60; cl11438 216595020645 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595020646 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595020648 Domain of unknown function DUF20; Region: UPF0118; cl00465 216595020650 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; cl01278 216595020651 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 216595020652 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196 216595020653 dimerization interface [polypeptide binding]; other site 216595020654 putative ATP binding site [chemical binding]; other site 216595020657 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 216595020658 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 216595020659 active site 216595020660 substrate binding site [chemical binding]; other site 216595020661 cosubstrate binding site; other site 216595020662 catalytic site [active] 216595020664 PS00373 Phosphoribosylglycinamide formyltransferase active site. 216595020665 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 216595020666 PS00052 Ribosomal protein S7 signature. 216595020667 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201 216595020668 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 216595020669 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 216595020670 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 216595020673 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 216595020674 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 216595020675 synthetase active site [active] 216595020676 NTP binding site [chemical binding]; other site 216595020677 metal binding site [ion binding]; metal-binding site 216595020678 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 216595020679 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 216595020683 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 216595020684 TRAM domain; Region: TRAM; cl01282 216595020685 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 216595020686 S-adenosylmethionine binding site [chemical binding]; other site 216595020687 PS01231 RNA methyltransferase trmA family signature 2. 216595020688 PS01230 RNA methyltransferase trmA family signature 1. 216595020691 cysteine synthases; Region: cysKM; TIGR01136 216595020692 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 216595020693 dimer interface [polypeptide binding]; other site 216595020694 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595020695 catalytic residue [active] 216595020697 PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. 216595020698 DTW domain; Region: DTW; cl01221 216595020700 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595020701 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595020702 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 216595020703 dimerization interface [polypeptide binding]; other site 216595020706 Arginase family; Region: Arginase; cl00306 216595020708 PS00147 Arginase family signature 1. 216595020709 PS00148 Arginase family signature 2. 216595020710 PS01053 Arginase family signature 3. 216595020711 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 216595020712 Sodium:solute symporter family; Region: SSF; cl00456 216595020714 12 probable transmembrane helices predicted for PFLU4512 by TMHMM2.0 at aa 36-58, 63-85, 106-128, 148-170, 177-196, 211-233, 254-276, 291-313, 334-356, 366-388, 420-442 and 452-474 216595020715 13 probable transmembrane helices predicted for PFLU4513 by TMHMM2.0 at aa 35-57, 78-100, 105-127, 155-177, 187-209, 216-238, 253-275, 296-318, 341-363, 384-406, 411-433, 440-457 and 467-484 216595020716 Sodium:solute symporter family; Region: SSF; cl00456 216595020718 PS00044 Bacterial regulatory proteins, lysR family signature. 216595020719 1 probable transmembrane helix predicted for PFLU4514 by TMHMM2.0 at aa 21-43 216595020720 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595020721 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595020722 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 216595020723 putative dimerization interface [polypeptide binding]; other site 216595020726 PS00044 Bacterial regulatory proteins, lysR family signature. 216595020727 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 216595020728 12 probable transmembrane helices predicted for PFLU4517 by TMHMM2.0 at aa 7-26, 41-63, 75-92, 102-124, 131-153, 163-182, 203-225, 235-257, 270-287, 291-313, 326-348 and 353-375 216595020730 Sodium:solute symporter family; Region: SSF; cl00456 216595020731 PS00017 ATP/GTP-binding site motif A (P-loop). 216595020733 Predicted membrane protein (DUF2177); Region: DUF2177; cl02014 216595020734 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 216595020735 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 216595020736 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 216595020737 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595020738 1 probable transmembrane helix predicted for PFLU4523 by TMHMM2.0 at aa 17-36 216595020739 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595020740 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 216595020741 helicase 45; Provisional; Region: PTZ00424 216595020742 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 216595020743 ATP binding site [chemical binding]; other site 216595020744 Mg++ binding site [ion binding]; other site 216595020745 motif III; other site 216595020746 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216595020747 nucleotide binding region [chemical binding]; other site 216595020748 ATP-binding site [chemical binding]; other site 216595020751 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 216595020752 PS00041 Bacterial regulatory proteins, araC family signature. 216595020753 PS00017 ATP/GTP-binding site motif A (P-loop). 216595020754 Mechanosensitive ion channel; Region: MS_channel; pfam00924 216595020755 4 probable transmembrane helices predicted for PFLU4527 by TMHMM2.0 at aa 45-67, 124-146, 166-188 and 193-210 216595020757 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 216595020760 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 216595020762 1 probable transmembrane helix predicted for PFLU4530 by TMHMM2.0 at aa 20-37 216595020763 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595020764 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595020765 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595020766 dimerization interface [polypeptide binding]; other site 216595020769 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 216595020770 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595020771 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595020773 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 216595020774 active site 216595020776 PS00170 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. 216595020777 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 216595020778 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 216595020779 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595020780 Walker A/P-loop; other site 216595020781 ATP binding site [chemical binding]; other site 216595020782 Q-loop/lid; other site 216595020783 ABC transporter signature motif; other site 216595020784 Walker B; other site 216595020785 D-loop; other site 216595020786 H-loop/switch region; other site 216595020787 6 probable transmembrane helices predicted for PFLU4534 by TMHMM2.0 at aa 39-61, 76-98, 157-179, 183-205, 271-293 and 297-319 216595020789 PS00017 ATP/GTP-binding site motif A (P-loop). 216595020790 PS00211 ABC transporters family signature. 216595020791 FemAB family; Region: FemAB; cl11444 216595020792 Protein of unknown function, DUF482; Region: DUF482; pfam04339 216595020794 1 probable transmembrane helix predicted for PFLU4536 by TMHMM2.0 at aa 35-54 216595020795 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216595020796 RNA polymerase sigma-70 factor, TIGR02943 family; Region: Sig70_famx1 216595020799 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 216595020800 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 216595020801 dimer interface [polypeptide binding]; other site 216595020802 active site 216595020803 CoA binding pocket [chemical binding]; other site 216595020806 PS00606 Beta-ketoacyl synthases active site. 216595020807 PS00017 ATP/GTP-binding site motif A (P-loop). 216595020808 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 216595020809 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216595020810 ATP binding site [chemical binding]; other site 216595020811 putative Mg++ binding site [ion binding]; other site 216595020812 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216595020813 nucleotide binding region [chemical binding]; other site 216595020814 ATP-binding site [chemical binding]; other site 216595020815 Helicase associated domain (HA2); Region: HA2; cl04503 216595020816 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 216595020817 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 216595020821 PS00017 ATP/GTP-binding site motif A (P-loop). 216595020822 Isocitrate dehydrogenase kinase/phosphatase (AceK); Region: AceK; cl01891 216595020824 PS00017 ATP/GTP-binding site motif A (P-loop). 216595020825 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 216595020826 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595020827 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595020828 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595020829 2 probable transmembrane helices predicted for PFLU4548 by TMHMM2.0 at aa 10-32 and 190-212 216595020832 EamA-like transporter family; Region: EamA; cl01037 216595020833 EamA-like transporter family; Region: EamA; cl01037 216595020834 10 probable transmembrane helices predicted for PFLU4549 by TMHMM2.0 at aa 13-32, 42-59, 72-94, 98-120, 127-149, 153-175, 188-210, 220-242, 249-271 and 276-295 216595020837 8 probable transmembrane helices predicted for PFLU4550 by TMHMM2.0 at aa 19-41, 45-67, 74-96, 126-143, 150-172, 182-201, 222-244 and 259-281 216595020838 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595020840 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216595020841 PAS fold; Region: PAS_3; pfam08447 216595020842 putative active site [active] 216595020843 heme pocket [chemical binding]; other site 216595020844 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595020845 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595020848 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 216595020849 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the...; Region: cbb3_Oxidase_I; cd01661 216595020850 Low-spin heme binding site [chemical binding]; other site 216595020851 Putative water exit pathway; other site 216595020852 Binuclear center (active site) [active] 216595020853 Putative proton exit pathway; other site 216595020854 12 probable transmembrane helices predicted for PFLU4553 by TMHMM2.0 at aa 51-73, 88-110, 123-142, 157-179, 191-213, 233-255, 268-285, 300-322, 335-357, 372-394, 407-429 and 463-485 216595020856 PS00077 Heme-copper oxidase catalytic subunit, copper B binding region signature. 216595020857 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 216595020859 1 probable transmembrane helix predicted for PFLU4554 by TMHMM2.0 at aa 13-35 216595020860 PS00190 Cytochrome c family heme-binding site signature. 216595020861 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of...; Region: cbb3_Oxidase_CcoQ; cl00282 216595020862 1 probable transmembrane helix predicted for PFLU4555 by TMHMM2.0 at aa 10-32 216595020863 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 216595020864 Cytochrome c; Region: Cytochrom_C; cl11414 216595020865 Cytochrome c; Region: Cytochrom_C; cl11414 216595020866 2 probable transmembrane helices predicted for PFLU4556 by TMHMM2.0 at aa 4-26 and 57-79 216595020868 PS00190 Cytochrome c family heme-binding site signature. 216595020870 PS00190 Cytochrome c family heme-binding site signature. 216595020871 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the...; Region: cbb3_Oxidase_I; cd01661 216595020872 Low-spin heme binding site [chemical binding]; other site 216595020873 Putative water exit pathway; other site 216595020874 Binuclear center (active site) [active] 216595020875 Putative proton exit pathway; other site 216595020876 12 probable transmembrane helices predicted for PFLU4558 by TMHMM2.0 at aa 45-67, 87-109, 122-141, 156-178, 185-207, 233-255, 262-284, 299-321, 334-356, 371-393, 406-428 and 462-484 216595020878 PS00077 Heme-copper oxidase catalytic subunit, copper B binding region signature. 216595020879 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 216595020881 1 probable transmembrane helix predicted for PFLU4559 by TMHMM2.0 at aa 12-34 216595020882 PS00190 Cytochrome c family heme-binding site signature. 216595020883 PS00017 ATP/GTP-binding site motif A (P-loop). 216595020884 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of...; Region: cbb3_Oxidase_CcoQ; cl00282 216595020886 1 probable transmembrane helix predicted for PFLU4560 by TMHMM2.0 at aa 4-26 216595020887 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 216595020888 Cytochrome c; Region: Cytochrom_C; cl11414 216595020889 Cytochrome c; Region: Cytochrom_C; cl11414 216595020890 2 probable transmembrane helices predicted for PFLU4561 by TMHMM2.0 at aa 4-26 and 57-79 216595020892 PS00190 Cytochrome c family heme-binding site signature. 216595020894 PS00190 Cytochrome c family heme-binding site signature. 216595020895 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 216595020896 4Fe-4S binding domain; Region: Fer4_5; pfam12801 216595020897 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 216595020898 5 probable transmembrane helices predicted for PFLU4563 by TMHMM2.0 at aa 46-68, 94-116, 169-188, 203-222 and 343-362 216595020900 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216595020901 FixH; Region: FixH; cl01254 216595020902 1 probable transmembrane helix predicted for PFLU4564 by TMHMM2.0 at aa 15-37 216595020903 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 216595020904 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 216595020905 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 216595020906 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216595020907 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 216595020908 7 probable transmembrane helices predicted for PFLU4565 by TMHMM2.0 at aa 173-195, 210-232, 245-267, 272-290, 425-447, 452-471 and 752-774 216595020911 PS00154 E1-E2 ATPases phosphorylation site. 216595020912 PS01229 Hypothetical cof family signature 2. 216595020913 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 216595020915 1 probable transmembrane helix predicted for PFLU4566 by TMHMM2.0 at aa 5-27 216595020916 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 216595020917 6 probable transmembrane helices predicted for PFLU4567 by TMHMM2.0 at aa 15-37, 49-71, 81-103, 135-157, 167-189 and 202-224 216595020918 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 216595020919 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 216595020920 FeS/SAM binding site; other site 216595020921 HemN C-terminal region; Region: HemN_C; pfam06969 216595020924 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 216595020925 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216595020926 ligand binding site [chemical binding]; other site 216595020927 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 216595020928 putative switch regulator; other site 216595020929 non-specific DNA interactions [nucleotide binding]; other site 216595020930 DNA binding site [nucleotide binding] 216595020931 sequence specific DNA binding site [nucleotide binding]; other site 216595020932 putative cAMP binding site [chemical binding]; other site 216595020935 PS00042 Bacterial regulatory proteins, crp family signature. 216595020936 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 216595020938 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 216595020939 Transposase; Region: DEDD_Tnp_IS110; pfam01548 216595020940 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 216595020943 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216595020944 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216595020945 active site 216595020948 PS00072 Acyl-CoA dehydrogenases signature 1. 216595020950 recombination protein RecR; Reviewed; Region: recR; PRK00076 216595020951 RecR protein; Region: RecR; pfam02132 216595020952 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 216595020953 putative active site [active] 216595020954 putative metal-binding site [ion binding]; other site 216595020955 tetramer interface [polypeptide binding]; other site 216595020958 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 216595020959 Prostaglandin dehydrogenases; Region: PGDH; cd05288 216595020960 NAD(P) binding site [chemical binding]; other site 216595020961 substrate binding site [chemical binding]; other site 216595020962 dimer interface [polypeptide binding]; other site 216595020964 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 216595020966 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 216595020967 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595020968 Walker A motif; other site 216595020969 ATP binding site [chemical binding]; other site 216595020970 Walker B motif; other site 216595020971 arginine finger; other site 216595020972 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 216595020974 PS00017 ATP/GTP-binding site motif A (P-loop). 216595020975 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216595020976 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 216595020977 putative dimer interface [polypeptide binding]; other site 216595020979 EamA-like transporter family; Region: EamA; cl01037 216595020980 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 216595020981 EamA-like transporter family; Region: EamA; cl01037 216595020984 PS00211 ABC transporters family signature. 216595020985 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595020986 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595020987 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595020988 dimerization interface [polypeptide binding]; other site 216595020990 PS00044 Bacterial regulatory proteins, lysR family signature. 216595020992 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595020993 Protein of unknown function (DUF3380); Region: DUF3380; pfam11860 216595020994 PS00017 ATP/GTP-binding site motif A (P-loop). 216595020995 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; cl09206 216595020996 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 216595020997 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 216595020998 nucleotide binding pocket [chemical binding]; other site 216595020999 K-X-D-G motif; other site 216595021000 catalytic site [active] 216595021001 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 216595021002 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 216595021003 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027 216595021004 Dimer interface [polypeptide binding]; other site 216595021007 PS01056 NAD-dependent DNA ligase signature 2. 216595021009 PS01055 NAD-dependent DNA ligase signature 1. 216595021010 Cell division protein [Cell division and chromosome partitioning]; Region: ZipA; COG3115 216595021011 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 216595021012 FtsZ protein binding site [polypeptide binding]; other site 216595021014 1 probable transmembrane helix predicted for PFLU4589 by TMHMM2.0 at aa 7-25 216595021015 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 216595021016 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 216595021017 Walker A/P-loop; other site 216595021018 ATP binding site [chemical binding]; other site 216595021019 Q-loop/lid; other site 216595021020 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 216595021021 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 216595021022 ABC transporter signature motif; other site 216595021023 Walker B; other site 216595021024 D-loop; other site 216595021025 H-loop/switch region; other site 216595021028 PS00017 ATP/GTP-binding site motif A (P-loop). 216595021029 Transcriptional regulators [Transcription]; Region: GntR; COG1802 216595021030 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595021031 DNA-binding site [nucleotide binding]; DNA binding site 216595021033 PS00043 Bacterial regulatory proteins, gntR family signature. 216595021034 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 216595021035 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216595021036 catalytic loop [active] 216595021037 iron binding site [ion binding]; other site 216595021038 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 216595021039 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 216595021041 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 216595021045 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 216595021046 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 216595021047 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 216595021050 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595021051 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 216595021052 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 216595021054 guanine deaminase; Provisional; Region: PRK09228 216595021055 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 216595021056 active site 216595021058 Transcriptional regulators [Transcription]; Region: GntR; COG1802 216595021059 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595021060 DNA-binding site [nucleotide binding]; DNA binding site 216595021061 FCD domain; Region: FCD; cl11656 216595021064 PS00043 Bacterial regulatory proteins, gntR family signature. 216595021065 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 216595021066 Sulfate transporter family; Region: Sulfate_transp; cl00967 216595021068 9 probable transmembrane helices predicted for PFLU4597 by TMHMM2.0 at aa 20-42, 52-74, 94-116, 131-153, 173-195, 210-232, 301-323, 328-347 and 368-390 216595021069 Protein with unknown function (DUF469); Region: DUF469; cl01237 216595021071 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 216595021072 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl15297 216595021073 probable transmembrane helix predicted for PFLU4599 by TMHMM2.0 at aa 7-26 216595021076 CHASE domain; Region: CHASE; cl01369 216595021077 PAS fold; Region: PAS; pfam00989 216595021078 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 216595021079 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216595021080 putative active site [active] 216595021081 heme pocket [chemical binding]; other site 216595021082 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216595021083 metal binding site [ion binding]; metal-binding site 216595021084 active site 216595021085 I-site; other site 216595021090 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 216595021091 THUMP domain; Region: THUMP; cl12076 216595021092 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 216595021093 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 216595021094 S-adenosylmethionine binding site [chemical binding]; other site 216595021096 PS00092 N-6 Adenine-specific DNA methylases signature. 216595021098 low GC content region (52.4%) 216595021099 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_2_like; cd04738 216595021100 quinone interaction residues [chemical binding]; other site 216595021101 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 216595021102 active site 216595021103 catalytic residues [active] 216595021104 FMN binding site [chemical binding]; other site 216595021105 substrate binding site [chemical binding]; other site 216595021107 PS00911 Dihydroorotate dehydrogenase signature 1. 216595021108 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 216595021109 N-acetyl-D-glucosamine binding site [chemical binding]; other site 216595021110 catalytic residue [active] 216595021113 type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339 216595021114 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 216595021115 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 216595021118 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 216595021119 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 216595021120 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595021121 active site 216595021122 phosphorylation site [posttranslational modification] 216595021123 intermolecular recognition site; other site 216595021124 dimerization interface [polypeptide binding]; other site 216595021125 ANTAR domain; Region: ANTAR; cl04297 216595021128 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 216595021129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595021130 putative substrate translocation pore; other site 216595021131 11 probable transmembrane helices predicted for PFLU4609 by TMHMM2.0 at aa 68-90, 103-125, 135-153, 160-182, 192-214, 219-241, 266-288, 326-348, 353-375, 388-410 and 420-439 216595021133 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 216595021134 Active site [active] 216595021135 Catalytic domain of Protein Kinases; Region: PKc; cd00180 216595021136 active site 216595021137 ATP binding site [chemical binding]; other site 216595021138 substrate binding site [chemical binding]; other site 216595021139 activation loop (A-loop); other site 216595021141 1 probable transmembrane helix predicted for PFLU4610 by TMHMM2.0 at aa 532-554 216595021142 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 216595021144 PS00839 Uroporphyrin-III C-methyltransferase signature 1. 216595021145 Surface antigen; Region: Surface_Ag_2; cl01155 216595021146 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216595021147 ligand binding site [chemical binding]; other site 216595021149 PS01068 OmpA-like domain. 216595021151 RNA polymerase sigma factor SigX; Reviewed; Region: PRK09640 216595021152 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216595021153 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 216595021158 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 216595021159 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 216595021161 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595021162 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 216595021164 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595021165 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216595021166 PhaC subunit; Region: PHA_synth_III_C; TIGR01836 216595021167 phosphoenolpyruvate synthase; Validated; Region: PRK06464 216595021168 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 216595021169 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 216595021170 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 216595021172 PS00742 PEP-utilizing enzymes signature 2. 216595021174 PS00370 PEP-utilizing enzymes phosphorylation site signature. 216595021176 PS00687 Aldehyde dehydrogenases glutamic acid active site. 216595021177 Domain of unknown function (DUF299); Region: DUF299; cl00780 216595021179 PS00017 ATP/GTP-binding site motif A (P-loop). 216595021180 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 216595021181 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595021182 DNA-binding site [nucleotide binding]; DNA binding site 216595021183 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216595021184 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595021185 homodimer interface [polypeptide binding]; other site 216595021186 catalytic residue [active] 216595021189 10 probable transmembrane helices predicted for PFLU4623 by TMHMM2.0 at aa 19-41, 56-73, 86-103, 113-133, 138-157, 167-189, 196-218, 233-255, 262-281 and 291-313 216595021190 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 216595021191 EamA-like transporter family; Region: EamA; cl01037 216595021193 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595021195 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 216595021196 MPN+ (JAMM) motif; other site 216595021197 Zinc-binding site [ion binding]; other site 216595021198 hypothetical protein; Validated; Region: PRK07411 216595021199 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 216595021200 ATP binding site [chemical binding]; other site 216595021201 substrate interface [chemical binding]; other site 216595021202 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 216595021203 active site residue [active] 216595021208 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 216595021209 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 216595021210 dimer interface [polypeptide binding]; other site 216595021211 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595021212 catalytic residue [active] 216595021214 serine O-acetyltransferase; Region: cysE; TIGR01172 216595021215 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354 216595021216 trimer interface [polypeptide binding]; other site 216595021217 active site 216595021218 substrate binding site [chemical binding]; other site 216595021219 CoA binding site [chemical binding]; other site 216595021224 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 216595021225 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 216595021226 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 216595021229 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 216595021230 2-methylcitrate dehydratase; Region: prpD; TIGR02330 216595021232 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 216595021234 1 probable transmembrane helix predicted for PFLU4629 by TMHMM2.0 at aa 318-340 216595021235 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 216595021236 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 216595021237 substrate binding site [chemical binding]; other site 216595021238 ligand binding site [chemical binding]; other site 216595021239 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 216595021240 substrate binding site [chemical binding]; other site 216595021244 Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108 216595021245 dimer interface [polypeptide binding]; other site 216595021246 Citrate synthase; Region: Citrate_synt; pfam00285 216595021247 active site 216595021248 citrylCoA binding site [chemical binding]; other site 216595021249 oxalacetate/citrate binding site [chemical binding]; other site 216595021250 coenzyme A binding site [chemical binding]; other site 216595021251 catalytic triad [active] 216595021253 PS00480 Citrate synthase signature. 216595021254 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 216595021255 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 216595021256 tetramer interface [polypeptide binding]; other site 216595021257 active site 216595021258 Mg2+/Mn2+ binding site [ion binding]; other site 216595021260 Transcriptional regulators [Transcription]; Region: GntR; COG1802 216595021261 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595021262 DNA-binding site [nucleotide binding]; DNA binding site 216595021263 FCD domain; Region: FCD; cl11656 216595021266 PS00043 Bacterial regulatory proteins, gntR family signature. 216595021267 Protein of unknown function (DUF785); Region: DUF785; cl01682 216595021269 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 216595021270 7 probable transmembrane helices predicted for PFLU4635 by TMHMM2.0 at aa 10-32, 313-335, 355-377, 384-406, 416-433, 440-462 and 467-489 216595021271 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 216595021273 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 216595021274 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 216595021275 chorismate binding enzyme; Region: Chorismate_bind; cl10555 216595021278 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 216595021279 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 216595021280 Transposase; Region: DEDD_Tnp_IS110; pfam01548 216595021281 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 216595021284 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 216595021285 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 216595021287 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 216595021288 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 216595021289 Active Sites [active] 216595021291 Sodium:solute symporter family; Region: SSF; cl00456 216595021293 12 probable transmembrane helices predicted for PFLU4643 by TMHMM2.0 at aa 80-102, 107-129, 162-184, 199-221, 234-256, 271-293, 306-328, 348-370, 391-413, 417-439, 473-495 and 499-516 216595021294 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 216595021296 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595021297 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595021298 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 216595021299 putative effector binding pocket; other site 216595021300 dimerization interface [polypeptide binding]; other site 216595021303 PS00044 Bacterial regulatory proteins, lysR family signature. 216595021304 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 216595021305 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595021306 NAD(P) binding site [chemical binding]; other site 216595021307 active site 216595021309 riboflavin kinase; Region: PLN02940 216595021310 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 216595021311 motif II; other site 216595021313 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 216595021314 2 probable transmembrane helices predicted for PFLU4648 by TMHMM2.0 at aa 13-32 and 96-118 216595021315 EamA-like transporter family; Region: EamA; cl01037 216595021316 EamA-like transporter family; Region: EamA; cl01037 216595021317 10 probable transmembrane helices predicted for PFLU4651 by TMHMM2.0 at aa 5-22, 27-49, 69-91, 95-117, 124-141, 146-165, 178-200, 210-232, 241-260 and 265-282 216595021320 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 216595021321 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 216595021323 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 216595021325 gamma-butyrobetaine hydroxylase; Region: carnitine_bodg; TIGR02409 216595021326 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cd00250 216595021327 substrate binding pocket [chemical binding]; other site 216595021328 active site 216595021329 iron coordination sites [ion binding]; other site 216595021331 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 216595021332 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595021333 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595021334 dimerization interface [polypeptide binding]; other site 216595021336 PS00044 Bacterial regulatory proteins, lysR family signature. 216595021338 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 216595021339 enoyl-CoA hydratase; Provisional; Region: PRK06213 216595021340 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 216595021341 substrate binding site [chemical binding]; other site 216595021342 oxyanion hole (OAH) forming residues; other site 216595021343 trimer interface [polypeptide binding]; other site 216595021345 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 216595021346 putative acyl-acceptor binding pocket; other site 216595021347 1 probable transmembrane helix predicted for PFLU4658 by TMHMM2.0 at aa 22-44 216595021349 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 216595021350 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 216595021352 2 probable transmembrane helices predicted for PFLU4659 by TMHMM2.0 at aa 266-285 and 295-317 216595021353 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 216595021354 catalytic triad [active] 216595021356 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 216595021357 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 216595021358 substrate binding site [chemical binding]; other site 216595021359 oxyanion hole (OAH) forming residues; other site 216595021360 trimer interface [polypeptide binding]; other site 216595021361 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 216595021362 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 216595021366 PS00166 Enoyl-CoA hydratase/isomerase signature. 216595021367 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 216595021368 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 216595021369 dimer interface [polypeptide binding]; other site 216595021370 active site 216595021372 PS00099 Thiolases active site. 216595021373 PS00737 Thiolases signature 2. 216595021375 PS00098 Thiolases acyl-enzyme intermediate signature. 216595021376 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 216595021377 Cytochrome c; Region: Cytochrom_C; cl11414 216595021378 PS00190 Cytochrome c family heme-binding site signature. 216595021379 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 216595021380 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 216595021383 Bacterial domain of unknown function (DUF403); Region: DUF403; cl00980 216595021385 Uncharacterized conserved protein [Function unknown]; Region: COG2308 216595021386 Domain of unknown function (DUF404); Region: DUF404; pfam04169 216595021387 Domain of unknown function (DUF407); Region: DUF407; pfam04174 216595021390 Protein of unknown function (DUF1260); Region: DUF1260; cl01170 216595021392 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876 216595021393 putative lipid binding site [chemical binding]; other site 216595021395 Flagellin N-methylase; Region: FliB; cl00497 216595021397 1 probable transmembrane helix predicted for PFLU4671 by TMHMM2.0 at aa 7-29 216595021398 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 216595021399 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595021400 DNA-binding site [nucleotide binding]; DNA binding site 216595021401 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216595021402 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595021403 homodimer interface [polypeptide binding]; other site 216595021404 catalytic residue [active] 216595021407 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216595021408 ligand binding site [chemical binding]; other site 216595021410 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595021411 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595021412 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216595021413 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595021414 substrate binding pocket [chemical binding]; other site 216595021415 membrane-bound complex binding site; other site 216595021416 hinge residues; other site 216595021417 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 216595021418 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 216595021419 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 216595021420 PS00696 Electron transfer flavoprotein alpha-subunit signature. 216595021423 Electron transfer flavoprotein, beta subunit [Energy production and conversion]; Region: FixA; COG2086 216595021424 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 216595021425 Ligand binding site [chemical binding]; other site 216595021427 PS01065 Electron transfer flavoprotein beta-subunit signature. 216595021428 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 216595021429 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595021430 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 216595021433 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 216595021434 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216595021435 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595021437 PS00041 Bacterial regulatory proteins, araC family signature. 216595021440 probable cinnamyl alcohol dehydrogenase; Region: PLN02586 216595021441 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 216595021442 putative NAD(P) binding site [chemical binding]; other site 216595021443 putative substrate binding site [chemical binding]; other site 216595021444 catalytic Zn binding site [ion binding]; other site 216595021445 structural Zn binding site [ion binding]; other site 216595021446 dimer interface [polypeptide binding]; other site 216595021448 PS00190 Cytochrome c family heme-binding site signature. 216595021449 PS00059 Zinc-containing alcohol dehydrogenases signature. 216595021451 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 216595021452 Transcriptional regulator [Transcription]; Region: IclR; COG1414 216595021453 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595021454 Bacterial transcriptional regulator; Region: IclR; pfam01614 216595021457 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216595021458 TM-ABC transporter signature motif; other site 216595021460 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 216595021461 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 216595021462 Walker A/P-loop; other site 216595021463 ATP binding site [chemical binding]; other site 216595021464 Q-loop/lid; other site 216595021465 ABC transporter signature motif; other site 216595021466 Walker B; other site 216595021467 D-loop; other site 216595021468 H-loop/switch region; other site 216595021469 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 216595021471 PS00213 Lipocalin signature. 216595021472 PS00211 ABC transporters family signature. 216595021474 PS00211 ABC transporters family signature. 216595021475 PS00017 ATP/GTP-binding site motif A (P-loop). 216595021476 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 216595021477 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 216595021478 ligand binding site [chemical binding]; other site 216595021480 short chain dehydrogenase; Provisional; Region: PRK07063 216595021481 classical (c) SDRs; Region: SDR_c; cd05233 216595021482 NAD(P) binding site [chemical binding]; other site 216595021483 active site 216595021485 PS00061 Short-chain dehydrogenases/reductases family signature. 216595021486 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 216595021487 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216595021488 Coenzyme A binding pocket [chemical binding]; other site 216595021490 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 216595021491 substrate binding site [chemical binding]; other site 216595021492 ATP binding site [chemical binding]; other site 216595021494 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 216595021495 Sodium:solute symporter family; Region: SSF; cl00456 216595021497 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 216595021499 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 216595021500 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595021501 DNA-binding site [nucleotide binding]; DNA binding site 216595021502 UTRA domain; Region: UTRA; cl01230 216595021505 PS00043 Bacterial regulatory proteins, gntR family signature. 216595021506 Protein of unknown function (DUF1285); Region: DUF1285; cl01571 216595021508 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595021509 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 216595021510 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 216595021511 FeS/SAM binding site; other site 216595021512 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 216595021515 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216595021516 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216595021519 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 216595021520 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 216595021521 active site 216595021523 PS01091 Uncharacterized protein family UPF0006 signature 3. 216595021524 PS01137 Uncharacterized protein family UPF0006 signature 1. 216595021525 DNA polymerase III subunit delta'; Validated; Region: PRK05707 216595021526 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595021527 thymidylate kinase; Validated; Region: tmk; PRK00698 216595021528 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 216595021529 TMP-binding site; other site 216595021530 ATP-binding site [chemical binding]; other site 216595021532 PS01331 Thymidylate kinase signature. 216595021533 PS00017 ATP/GTP-binding site motif A (P-loop). 216595021534 YceG-like family; Region: YceG; pfam02618 216595021535 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 216595021536 dimerization interface [polypeptide binding]; other site 216595021538 1 probable transmembrane helix predicted for PFLU4701 by TMHMM2.0 at aa 5-25 216595021539 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 216595021540 Aminotransferase class IV; Region: Aminotran_4; pfam01063 216595021541 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595021542 catalytic residue [active] 216595021544 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 216595021545 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 216595021546 dimer interface [polypeptide binding]; other site 216595021547 active site 216595021550 PS00606 Beta-ketoacyl synthases active site. 216595021551 Phosphopantetheine attachment site; Region: PP-binding; cl09936 216595021552 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 216595021554 PS00012 Phosphopantetheine attachment site. 216595021555 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 216595021556 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 216595021557 NAD(P) binding site [chemical binding]; other site 216595021558 homotetramer interface [polypeptide binding]; other site 216595021559 homodimer interface [polypeptide binding]; other site 216595021560 active site 216595021562 PS00061 Short-chain dehydrogenases/reductases family signature. 216595021563 Acyl transferase domain; Region: Acyl_transf_1; cl08282 216595021564 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 216595021566 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 216595021568 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 216595021570 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 216595021572 Maf-like protein; Region: Maf; pfam02545 216595021573 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 216595021574 active site 216595021575 dimer interface [polypeptide binding]; other site 216595021577 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 216595021578 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 216595021579 tandem repeat interface [polypeptide binding]; other site 216595021580 oligomer interface [polypeptide binding]; other site 216595021581 active site residues [active] 216595021583 1 probable transmembrane helix predicted for PFLU4711 by TMHMM2.0 at aa 39-61 216595021584 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 216595021585 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 216595021586 motif II; other site 216595021588 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 216595021589 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 216595021590 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 216595021591 active site 216595021593 PS01129 Rlu family of pseudouridine synthase signature. 216595021595 ribonuclease E; Reviewed; Region: rne; PRK10811 216595021596 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 216595021597 homodimer interface [polypeptide binding]; other site 216595021598 oligonucleotide binding site [chemical binding]; other site 216595021600 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 216595021601 Ligand binding site [chemical binding]; other site 216595021602 metal binding site [ion binding]; metal-binding site 216595021603 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 216595021604 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 216595021606 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 216595021608 PS00714 Sodium:dicarboxylate symporter family signature 2. 216595021609 PS00713 Sodium:dicarboxylate symporter family signature 1. 216595021610 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 216595021611 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216595021612 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595021614 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 216595021615 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 216595021616 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 216595021617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595021618 ATP binding site [chemical binding]; other site 216595021619 G-X-G motif; other site 216595021623 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 216595021624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595021625 active site 216595021626 phosphorylation site [posttranslational modification] 216595021627 intermolecular recognition site; other site 216595021628 dimerization interface [polypeptide binding]; other site 216595021629 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 216595021630 DNA binding site [nucleotide binding] 216595021633 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 216595021634 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 216595021636 sensor protein RstB; Provisional; Region: PRK10604 216595021637 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 216595021638 dimerization interface [polypeptide binding]; other site 216595021639 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595021640 dimer interface [polypeptide binding]; other site 216595021641 phosphorylation site [posttranslational modification] 216595021642 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595021643 ATP binding site [chemical binding]; other site 216595021644 Mg2+ binding site [ion binding]; other site 216595021645 G-X-G motif; other site 216595021647 PS00017 ATP/GTP-binding site motif A (P-loop). 216595021650 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 216595021651 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595021652 active site 216595021653 phosphorylation site [posttranslational modification] 216595021654 intermolecular recognition site; other site 216595021655 dimerization interface [polypeptide binding]; other site 216595021656 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 216595021657 DNA binding site [nucleotide binding] 216595021660 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 216595021661 ATP cone domain; Region: ATP-cone; pfam03477 216595021662 ATP cone domain; Region: ATP-cone; pfam03477 216595021663 Class I ribonucleotide reductase; Region: RNR_I; cd01679 216595021664 active site 216595021665 dimer interface [polypeptide binding]; other site 216595021666 catalytic residues [active] 216595021667 effector binding site; other site 216595021668 R2 peptide binding site; other site 216595021672 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 216595021673 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 216595021674 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 216595021675 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 216595021679 PS00588 Flagella basal body rod proteins signature. 216595021680 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 216595021681 Flagellar hook capping protein; Region: FlgD; cl04347 216595021683 PS00012 Phosphopantetheine attachment site. 216595021684 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 216595021685 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 216595021686 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 216595021689 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 216595021690 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 216595021692 PS00588 Flagella basal body rod proteins signature. 216595021693 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 216595021694 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 216595021695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 216595021698 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 216595021699 Response regulator receiver domain; Region: Response_reg; pfam00072 216595021700 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595021701 active site 216595021702 phosphorylation site [posttranslational modification] 216595021703 intermolecular recognition site; other site 216595021704 dimerization interface [polypeptide binding]; other site 216595021707 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 216595021708 SAF domain; Region: SAF; cl00555 216595021710 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 216595021712 FlgN protein; Region: FlgN; cl09176 216595021714 Flagellar regulator YcgR; Region: YcgR; pfam07317 216595021715 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 216595021716 PilZ domain; Region: PilZ; cl01260 216595021718 putative MFS family transporter protein; Provisional; Region: PRK03633 216595021719 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595021720 putative substrate translocation pore; other site 216595021722 2 probable transmembrane helices predicted for PFLU4742 by TMHMM2.0 at aa 5-22 and 27-49 216595021723 Arc-like DNA binding domain; Region: Arc; pfam03869 216595021725 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 216595021726 MgtE intracellular N domain; Region: MgtE_N; cl15244 216595021727 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 216595021728 Divalent cation transporter; Region: MgtE; cl00786 216595021732 Global regulator protein family; Region: CsrA; cl00670 216595021734 aspartate kinase; Reviewed; Region: PRK06635 216595021735 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 216595021736 putative nucleotide binding site [chemical binding]; other site 216595021737 putative catalytic residues [active] 216595021738 putative Mg ion binding site [ion binding]; other site 216595021739 putative aspartate binding site [chemical binding]; other site 216595021740 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 216595021741 putative allosteric regulatory site; other site 216595021742 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 216595021743 putative allosteric regulatory residue; other site 216595021747 PS00324 Aspartokinase signature. 216595021748 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 216595021749 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 216595021750 motif 1; other site 216595021751 active site 216595021752 motif 2; other site 216595021753 motif 3; other site 216595021754 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 216595021758 PS00017 ATP/GTP-binding site motif A (P-loop). 216595021759 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216595021760 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 216595021761 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 216595021762 tetramer interface [polypeptide binding]; other site 216595021763 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595021764 catalytic residue [active] 216595021766 ggaaccnnnnnnnnnnnnnnnnccacnna 216595021767 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-II; Region: Lumazine_synthase-II; cd09208 216595021768 active site 216595021769 homopentamer interface [polypeptide binding]; other site 216595021770 dimer interface [polypeptide binding]; other site 216595021772 Peptidase M14 Succinylglutamate desuccinylase (ASTE, also known as N-succinyl-L-glutamate amidohydrolase, N2-succinylglutamate desuccinylase, and SGDS; EC 3.5.1.96) belongs to the Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) subfamily...; Region: M14_ASTE; cd03855 216595021773 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 216595021774 putative active site [active] 216595021775 Zn-binding site [ion binding]; other site 216595021777 Succinylarginine dihydrolase; Region: AstB; cl01511 216595021779 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216595021780 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 216595021781 NAD(P) binding site [chemical binding]; other site 216595021782 catalytic residues [active] 216595021784 PS00070 Aldehyde dehydrogenases cysteine active site. 216595021785 PS00687 Aldehyde dehydrogenases glutamic acid active site. 216595021786 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 216595021787 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 216595021789 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 216595021790 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 216595021792 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 216595021793 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 216595021794 inhibitor-cofactor binding pocket; inhibition site 216595021795 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595021796 catalytic residue [active] 216595021798 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 216595021799 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl15309 216595021800 Substrate binding site [chemical binding]; other site 216595021801 leucine-rich repeat receptor-like protein kinase; Provisional; Region: PLN00113 216595021802 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl15309 216595021803 Substrate binding site [chemical binding]; other site 216595021811 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 216595021812 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 216595021813 conserved cys residue [active] 216595021814 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595021815 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595021817 PS00041 Bacterial regulatory proteins, araC family signature. 216595021819 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 216595021820 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 216595021821 Walker A/P-loop; other site 216595021822 ATP binding site [chemical binding]; other site 216595021823 Q-loop/lid; other site 216595021824 ABC transporter signature motif; other site 216595021825 Walker B; other site 216595021826 D-loop; other site 216595021827 H-loop/switch region; other site 216595021829 PS00211 ABC transporters family signature. 216595021830 PS00017 ATP/GTP-binding site motif A (P-loop). 216595021831 Predicted deacylase [General function prediction only]; Region: COG3608 216595021832 An uncharacterized subgroup of the Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) subfamily which is part of the the M14 family of metallocarboxypeptidases. This subgroup includes Pseudomonas aeruginosa AotO and related proteins. ASTE...; Region: M14_PaAOTO_like; cd06250 216595021833 putative active site [active] 216595021834 Zn-binding site [ion binding]; other site 216595021836 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595021837 dimer interface [polypeptide binding]; other site 216595021838 conserved gate region; other site 216595021839 putative PBP binding loops; other site 216595021840 ABC-ATPase subunit interface; other site 216595021842 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595021843 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216595021844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595021845 dimer interface [polypeptide binding]; other site 216595021846 conserved gate region; other site 216595021847 putative PBP binding loops; other site 216595021848 ABC-ATPase subunit interface; other site 216595021850 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595021851 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 216595021852 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595021853 substrate binding pocket [chemical binding]; other site 216595021854 membrane-bound complex binding site; other site 216595021855 hinge residues; other site 216595021858 acetyl-CoA synthetase; Provisional; Region: PRK00174 216595021859 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 216595021860 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595021862 PS00455 Putative AMP-binding domain signature. 216595021863 PFI-10 216595021864 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 216595021865 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 216595021866 dimer interface [polypeptide binding]; other site 216595021867 putative radical transfer pathway; other site 216595021868 diiron center [ion binding]; other site 216595021869 tyrosyl radical; other site 216595021871 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 216595021872 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595021873 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 216595021874 ABC transporter signature motif; other site 216595021875 Walker B; other site 216595021876 D-loop; other site 216595021877 H-loop/switch region; other site 216595021878 PS00017 ATP/GTP-binding site motif A (P-loop). 216595021880 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 216595021881 active site 216595021883 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 216595021884 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 216595021885 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 216595021886 oligomeric interface; other site 216595021887 putative active site [active] 216595021888 homodimer interface [polypeptide binding]; other site 216595021891 5 probable transmembrane helices predicted for PFLU4775 by TMHMM2.0 at aa 4-26, 33-52, 58-80, 93-115 and 119-141 216595021893 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 216595021894 amidase; Provisional; Region: PRK08137 216595021895 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 216595021897 PS00017 ATP/GTP-binding site motif A (P-loop). 216595021898 PS00217 Sugar transport proteins signature 2. 216595021899 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 216595021900 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216595021901 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216595021903 PS01081 Bacterial regulatory proteins, tetR family signature. 216595021904 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 216595021905 MASE2 domain; Region: MASE2; pfam05230 216595021906 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216595021907 metal binding site [ion binding]; metal-binding site 216595021908 active site 216595021909 I-site; other site 216595021911 4 probable transmembrane helices predicted for PFLU4782 by TMHMM2.0 at aa 50-72, 112-134, 147-169 and 179-201 216595021913 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216595021914 PAS fold; Region: PAS_4; pfam08448 216595021915 putative active site [active] 216595021916 heme pocket [chemical binding]; other site 216595021917 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216595021918 PAS fold; Region: PAS_4; pfam08448 216595021919 putative active site [active] 216595021920 heme pocket [chemical binding]; other site 216595021921 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595021925 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 216595021927 2 probable transmembrane helices predicted for PFLU4784 by TMHMM2.0 at aa 42-64 and 74-96 216595021928 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595021929 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595021930 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595021931 dimerization interface [polypeptide binding]; other site 216595021934 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 216595021935 conserved cys residue [active] 216595021937 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 216595021939 Protein of unknown function (DUF2025); Region: DUF2025; pfam09634 216595021940 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 216595021941 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 216595021942 active site 216595021943 catalytic site [active] 216595021944 metal binding site [ion binding]; metal-binding site 216595021946 PS00017 ATP/GTP-binding site motif A (P-loop). 216595021947 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 216595021949 GAF domain; Region: GAF; cl00853 216595021950 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595021951 dimer interface [polypeptide binding]; other site 216595021952 phosphorylation site [posttranslational modification] 216595021953 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595021954 ATP binding site [chemical binding]; other site 216595021955 Mg2+ binding site [ion binding]; other site 216595021956 G-X-G motif; other site 216595021960 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595021961 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595021962 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595021965 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 216595021966 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 216595021968 2 probable transmembrane helices predicted for PFLU4793 by TMHMM2.0 at aa 278-300 and 315-334 216595021969 Phosphate transporter family; Region: PHO4; cl00396 216595021970 Phosphate transporter family; Region: PHO4; cl00396 216595021971 10 probable transmembrane helices predicted for PFLU4794 by TMHMM2.0 at aa 27-49, 62-84, 104-126, 146-168, 175-192, 207-229, 249-266, 276-293, 420-439 and 512-534 216595021973 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 216595021974 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 216595021976 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 216595021977 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 216595021978 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 216595021980 LamB/YcsF family; Region: LamB_YcsF; cl00664 216595021982 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595021983 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595021984 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 216595021985 putative substrate binding pocket [chemical binding]; other site 216595021986 dimerization interface [polypeptide binding]; other site 216595021989 transcriptional regulator; Provisional; Region: PRK10632 216595021990 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595021991 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 216595021992 putative effector binding pocket; other site 216595021993 putative dimerization interface [polypeptide binding]; other site 216595021996 PS00044 Bacterial regulatory proteins, lysR family signature. 216595021997 short chain dehydrogenase; Provisional; Region: PRK12939 216595021998 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595021999 NAD(P) binding site [chemical binding]; other site 216595022000 active site 216595022002 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595022003 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595022004 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 216595022005 dimerization interface [polypeptide binding]; other site 216595022007 PS00017 ATP/GTP-binding site motif A (P-loop). 216595022009 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 216595022010 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216595022014 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 216595022015 putative hydrophobic ligand binding site [chemical binding]; other site 216595022017 YCII-related domain; Region: YCII; cl00999 216595022019 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 216595022020 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 216595022021 PS00430 TonB-dependent receptor proteins signature 1. 216595022023 low G+C content region 48.38% 216595022024 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 216595022026 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 216595022028 aspartate aminotransferase; Provisional; Region: PRK07681 216595022029 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216595022030 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595022031 homodimer interface [polypeptide binding]; other site 216595022032 catalytic residue [active] 216595022034 gluconate transporter; Region: gntP; TIGR00791 216595022035 GntP family permease; Region: GntP_permease; cl15264 216595022037 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 216595022038 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 216595022039 ATP-binding site [chemical binding]; other site 216595022040 Gluconate-6-phosphate binding site [chemical binding]; other site 216595022041 PS00017 ATP/GTP-binding site motif A (P-loop). 216595022042 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216595022043 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216595022044 DNA binding site [nucleotide binding] 216595022045 domain linker motif; other site 216595022046 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 216595022047 putative ligand binding site [chemical binding]; other site 216595022048 putative dimerization interface [polypeptide binding]; other site 216595022050 PS00356 Bacterial regulatory proteins, lacI family signature. 216595022052 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 216595022053 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 216595022054 putative C-terminal domain interface [polypeptide binding]; other site 216595022055 putative GSH binding site (G-site) [chemical binding]; other site 216595022056 putative dimer interface [polypeptide binding]; other site 216595022057 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 216595022058 putative N-terminal domain interface [polypeptide binding]; other site 216595022059 putative dimer interface [polypeptide binding]; other site 216595022060 putative substrate binding pocket (H-site) [chemical binding]; other site 216595022063 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 216595022064 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595022065 NAD(P) binding site [chemical binding]; other site 216595022066 active site 216595022067 PS00017 ATP/GTP-binding site motif A (P-loop). 216595022069 benzoate transport; Region: 2A0115; TIGR00895 216595022070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595022071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595022072 12 probable transmembrane helices predicted for PFLU4817 by TMHMM2.0 at aa 25-47, 78-100, 107-129, 133-155, 167-189, 199-216, 286-308, 318-340, 347-364, 368-390, 407-429 and 434-456 216595022074 PS00216 Sugar transport proteins signature 1. 216595022075 PS00217 Sugar transport proteins signature 2. 216595022076 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 216595022077 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216595022078 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 216595022079 putative active site [active] 216595022080 heme pocket [chemical binding]; other site 216595022081 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216595022082 putative active site [active] 216595022083 heme pocket [chemical binding]; other site 216595022084 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595022088 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595022089 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595022090 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 216595022091 dimerization interface [polypeptide binding]; other site 216595022094 PS00044 Bacterial regulatory proteins, lysR family signature. 216595022095 glutathionine S-transferase; Provisional; Region: PRK10542 216595022096 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_N_Beta; cd03057 216595022097 C-terminal domain interface [polypeptide binding]; other site 216595022098 GSH binding site (G-site) [chemical binding]; other site 216595022099 dimer interface [polypeptide binding]; other site 216595022100 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 216595022101 dimer interface [polypeptide binding]; other site 216595022102 N-terminal domain interface [polypeptide binding]; other site 216595022103 substrate binding pocket (H-site) [chemical binding]; other site 216595022106 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 216595022108 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 216595022110 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 216595022111 active site 216595022112 catalytic residues [active] 216595022113 metal binding site [ion binding]; metal-binding site 216595022115 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 216595022117 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677 216595022118 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595022120 PS00455 Putative AMP-binding domain signature. 216595022121 PS00017 ATP/GTP-binding site motif A (P-loop). 216595022122 long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12492 216595022123 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595022125 PS00455 Putative AMP-binding domain signature. 216595022126 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 216595022127 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595022128 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595022129 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595022131 PS00120 Lipases, serine active site. 216595022132 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of...; Region: R_hydratase; cd03449 216595022133 dimer interaction site [polypeptide binding]; other site 216595022134 substrate-binding tunnel; other site 216595022135 active site 216595022136 catalytic site [active] 216595022137 substrate binding site [chemical binding]; other site 216595022139 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595022140 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 216595022141 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 216595022142 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 216595022143 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 216595022144 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216595022145 catalytic residue [active] 216595022147 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 216595022148 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 216595022149 active site 216595022150 intersubunit interface [polypeptide binding]; other site 216595022151 catalytic residue [active] 216595022153 PS00160 KDPG and KHG aldolases Schiff-base forming residue. 216595022154 PS00159 KDPG and KHG aldolases active site. 216595022155 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 216595022156 putative active site [active] 216595022157 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 216595022158 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 216595022159 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 216595022162 PS00069 Glucose-6-phosphate dehydrogenase active site. 216595022163 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 216595022164 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 216595022165 putative active site [active] 216595022168 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 216595022169 active site 216595022170 phosphate binding residues; other site 216595022171 catalytic residues [active] 216595022173 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 216595022174 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 216595022176 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216595022177 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 216595022178 Walker A/P-loop; other site 216595022179 ATP binding site [chemical binding]; other site 216595022180 Q-loop/lid; other site 216595022181 ABC transporter signature motif; other site 216595022182 Walker B; other site 216595022183 D-loop; other site 216595022184 H-loop/switch region; other site 216595022185 TOBE domain; Region: TOBE_2; cl01440 216595022188 PS00211 ABC transporters family signature. 216595022189 PS00017 ATP/GTP-binding site motif A (P-loop). 216595022190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595022191 dimer interface [polypeptide binding]; other site 216595022192 conserved gate region; other site 216595022193 putative PBP binding loops; other site 216595022194 ABC-ATPase subunit interface; other site 216595022196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595022197 dimer interface [polypeptide binding]; other site 216595022198 conserved gate region; other site 216595022199 putative PBP binding loops; other site 216595022200 ABC-ATPase subunit interface; other site 216595022202 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595022204 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216595022205 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595022207 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 216595022208 putative active cleft [active] 216595022210 6 probable transmembrane helices predicted for PFLU4849 by TMHMM2.0 at aa 13-35, 40-62, 74-93, 108-130, 135-152 and 187-209 216595022211 1 probable transmembrane helix predicted for PFLU4850 by TMHMM2.0 at aa 48-70 216595022212 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216595022213 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595022214 NAD(P) binding site [chemical binding]; other site 216595022215 active site 216595022217 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 216595022218 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595022219 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595022220 dimerization interface [polypeptide binding]; other site 216595022223 PS00044 Bacterial regulatory proteins, lysR family signature. 216595022224 ACT domain; Region: ACT_3; cl01447 216595022226 LysE type translocator; Region: LysE; cl00565 216595022227 6 probable transmembrane helices predicted for PFLU4854 by TMHMM2.0 at aa 5-27, 40-62, 67-89, 110-132, 147-169 and 176-198 216595022229 superoxide dismutase; Provisional; Region: PRK10543 216595022230 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 216595022231 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 216595022233 PS00017 ATP/GTP-binding site motif A (P-loop). 216595022235 PS00088 Manganese and iron superoxide dismutases signature. 216595022236 PS00017 ATP/GTP-binding site motif A (P-loop). 216595022237 ggaaccnnnnnnnnnnnnnnnnccacnna 216595022238 biofilm formation regulator HmsP; Provisional; Region: PRK11829 216595022239 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216595022240 metal binding site [ion binding]; metal-binding site 216595022241 active site 216595022242 I-site; other site 216595022243 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216595022244 2 probable transmembrane helices predicted for PFLU4858 by TMHMM2.0 at aa 13-35 and 157-179 216595022247 PS00017 ATP/GTP-binding site motif A (P-loop). 216595022248 Imelysin; Region: Peptidase_M75; cl09159 216595022249 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 216595022250 Cation transport protein; Region: TrkH; cl10514 216595022251 10 probable transmembrane helices predicted for PFLU4861 by TMHMM2.0 at aa 12-34, 44-61, 73-95, 138-160, 181-203, 238-260, 273-295, 333-355, 395-417 and 457-479 216595022253 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 216595022254 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216595022255 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595022257 Protein of unknown function (DUF962); Region: DUF962; cl01879 216595022258 2 probable transmembrane helices predicted for PFLU4863 by TMHMM2.0 at aa 29-46 and 50-72 216595022259 major facilitator superfamily transporter; Provisional; Region: PRK05122 216595022260 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 216595022261 putative substrate translocation pore; other site 216595022262 12 probable transmembrane helices predicted for PFLU4866 by TMHMM2.0 at aa 13-35, 45-67, 80-102, 112-134, 146-168, 172-194, 215-237, 248-267, 274-296, 306-328, 337-359 and 364-386 216595022264 RF-1 domain; Region: RF-1; cl02875 216595022266 PS00745 Prokaryotic-type class I peptide chain release factors signature. 216595022267 PS00228 Tubulin-beta mRNA autoregulation signal. 216595022268 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 216595022269 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 216595022274 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 216595022275 Amino acid permease; Region: AA_permease; pfam00324 216595022277 PS00218 Amino acid permeases signature. 216595022278 low G+C region (42.15%) 216595022279 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 216595022280 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 216595022281 Integrase core domain; Region: rve; cl01316 216595022283 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 216595022284 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 216595022285 RNA binding surface [nucleotide binding]; other site 216595022286 PseudoU_synth_RluB: Pseudouridine synthase, Escherichia coli RluB like. This group is comprised of bacterial and eukaryotic proteins similar to E. coli RluB. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluB; cd02556 216595022287 probable active site [active] 216595022289 PS01149 Rsu family of pseudouridine synthase signature. 216595022291 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 216595022293 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 216595022295 ScpA/B protein; Region: ScpA_ScpB; cl00598 216595022297 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 216595022299 PS01147 SUA5/yciO/yrdC family signature. 216595022300 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 216595022301 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 216595022303 Intracellular septation protein A; Region: IspA; cl01098 216595022305 6 probable transmembrane helices predicted for PFLU4881 by TMHMM2.0 at aa 7-29, 44-66, 79-96, 106-128, 148-167 and 177-196 216595022306 YCII-related domain; Region: YCII; cl00999 216595022308 PsiA protein; Region: PsiA; cl11646 216595022309 1 probable transmembrane helix predicted for PFLU4883 by TMHMM2.0 at aa 105-127 216595022310 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216595022311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595022312 active site 216595022313 phosphorylation site [posttranslational modification] 216595022314 intermolecular recognition site; other site 216595022315 dimerization interface [polypeptide binding]; other site 216595022316 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 216595022317 DNA binding site [nucleotide binding] 216595022321 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595022322 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 216595022323 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595022324 ATP binding site [chemical binding]; other site 216595022325 Mg2+ binding site [ion binding]; other site 216595022326 G-X-G motif; other site 216595022327 2 probable transmembrane helices predicted for PFLU4886 by TMHMM2.0 at aa 4-26 and 152-174 216595022331 CoA-transferase family III; Region: CoA_transf_3; cl00778 216595022333 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 216595022334 AlkA N-terminal domain; Region: AlkA_N; cl05528 216595022335 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 216595022336 minor groove reading motif; other site 216595022337 helix-hairpin-helix signature motif; other site 216595022338 substrate binding pocket [chemical binding]; other site 216595022339 active site 216595022342 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 216595022344 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 216595022345 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 216595022346 13 probable transmembrane helices predicted for PFLU4890 by TMHMM2.0 at aa 20-40, 53-75, 85-107, 109-131, 136-155, 162-184, 211-233, 246-268, 292-314, 342-364, 369-391, 411-433 and 463-485 216595022348 Amidinotransferase; Region: Amidinotransf; cl12043 216595022349 Arginine deiminase [Amino acid transport and metabolism]; Region: ArcA; COG2235 216595022351 PS00687 Aldehyde dehydrogenases glutamic acid active site. 216595022352 ornithine carbamoyltransferase; Validated; Region: PRK02102 216595022353 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 216595022354 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595022356 PS00097 Aspartate and ornithine carbamoyltransferases signature. 216595022358 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 216595022359 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 216595022360 putative substrate binding site [chemical binding]; other site 216595022361 nucleotide binding site [chemical binding]; other site 216595022362 nucleotide binding site [chemical binding]; other site 216595022363 homodimer interface [polypeptide binding]; other site 216595022365 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 216595022366 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 216595022367 putative aromatic amino acid binding site; other site 216595022368 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 216595022369 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595022370 Walker A motif; other site 216595022371 ATP binding site [chemical binding]; other site 216595022372 Walker B motif; other site 216595022373 arginine finger; other site 216595022377 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 216595022378 PS00688 Sigma-54 interaction domain C-terminal part signature. 216595022379 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 216595022380 lipoyl attachment site [posttranslational modification]; other site 216595022382 glycine dehydrogenase; Provisional; Region: PRK05367 216595022383 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 216595022384 tetramer interface [polypeptide binding]; other site 216595022385 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595022386 catalytic residue [active] 216595022387 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 216595022388 tetramer interface [polypeptide binding]; other site 216595022389 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595022390 catalytic residue [active] 216595022392 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 216595022393 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 216595022394 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 216595022397 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 216595022398 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 216595022401 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 216595022402 DNA-binding site [nucleotide binding]; DNA binding site 216595022403 RNA-binding motif; other site 216595022405 PS00352 'Cold-shock' DNA-binding domain signature. 216595022406 RDD family; Region: RDD; cl00746 216595022408 3 probable transmembrane helices predicted for PFLU4901 by TMHMM2.0 at aa 25-47, 68-90 and 116-138 216595022409 Quinolinate synthetase A protein; Region: NadA; cl00420 216595022411 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 216595022412 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl09488 216595022414 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 216595022415 Ligand Binding Site [chemical binding]; other site 216595022417 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 216595022418 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 216595022419 FeS/SAM binding site; other site 216595022421 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 216595022422 1 probable transmembrane helix predicted for PFLU4906 by TMHMM2.0 at aa 7-24 216595022423 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216595022424 ligand binding site [chemical binding]; other site 216595022426 PS01068 OmpA-like domain. 216595022427 PS00697 ATP-dependent DNA ligase AMP-binding site. 216595022428 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595022429 translocation protein TolB; Provisional; Region: tolB; PRK00178 216595022430 TolB amino-terminal domain; Region: TolB_N; pfam04052 216595022431 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 216595022432 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 216595022439 TolA protein; Region: tolA_full; TIGR02794 216595022440 Gram-negative bacterial tonB protein; Region: TonB; cl10048 216595022442 1 probable transmembrane helix predicted for PFLU4909 by TMHMM2.0 at aa 13-35 216595022443 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 216595022445 1 probable transmembrane helix predicted for PFLU4910 by TMHMM2.0 at aa 19-41 216595022446 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 216595022447 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 216595022449 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 216595022450 active site 216595022452 PS00036 bZIP transcription factors basic domain signature. 216595022453 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 216595022454 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595022455 Walker A motif; other site 216595022456 ATP binding site [chemical binding]; other site 216595022457 Walker B motif; other site 216595022458 arginine finger; other site 216595022459 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 216595022462 PS00017 ATP/GTP-binding site motif A (P-loop). 216595022464 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 216595022465 RuvA N terminal domain; Region: RuvA_N; pfam01330 216595022466 Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cl11966 216595022467 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 216595022471 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 216595022472 active site 216595022473 putative DNA-binding cleft [nucleotide binding]; other site 216595022474 dimer interface [polypeptide binding]; other site 216595022476 PS01321 Crossover junction endodeoxyribonuclease ruvC signature. 216595022477 Domain of unknown function DUF28; Region: DUF28; cl00361 216595022479 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 216595022480 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 216595022481 dimer interface [polypeptide binding]; other site 216595022482 anticodon binding site; other site 216595022483 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 216595022484 homodimer interface [polypeptide binding]; other site 216595022485 motif 1; other site 216595022486 active site 216595022487 motif 2; other site 216595022488 GAD domain; Region: GAD; pfam02938 216595022489 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 216595022490 active site 216595022491 motif 3; other site 216595022493 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216595022495 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 216595022497 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 216595022498 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 216595022499 Ferritin-like domain; Region: Ferritin; pfam00210 216595022500 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 216595022501 dimerization interface [polypeptide binding]; other site 216595022502 DPS ferroxidase diiron center [ion binding]; other site 216595022503 ion pore; other site 216595022505 PS00819 Dps protein family signature 2. 216595022506 PS00818 Dps protein family signature 1. 216595022507 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 216595022508 DNA-binding site [nucleotide binding]; DNA binding site 216595022509 RNA-binding motif; other site 216595022511 PS00352 'Cold-shock' DNA-binding domain signature. 216595022512 SlyX; Region: SlyX; cl01090 216595022514 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 216595022516 outer membrane porin, OprD family; Region: OprD; pfam03573 216595022518 mechanosensitive channel MscS; Provisional; Region: PRK10334 216595022519 Mechanosensitive ion channel; Region: MS_channel; pfam00924 216595022521 PS01246 Uncharacterized protein family UPF0003 signature. 216595022522 Protein of unknown function (DUF520); Region: DUF520; cl00723 216595022524 2-dehydropantoate 2-reductase; Provisional; Region: PRK05708 216595022525 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595022526 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 216595022529 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 216595022530 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595022531 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 216595022532 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 216595022533 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595022534 dimer interface [polypeptide binding]; other site 216595022535 phosphorylation site [posttranslational modification] 216595022536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595022537 ATP binding site [chemical binding]; other site 216595022538 Mg2+ binding site [ion binding]; other site 216595022539 G-X-G motif; other site 216595022540 2 probable transmembrane helices predicted for PFLU4929 by TMHMM2.0 at aa 5-27 and 142-164 216595022545 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 216595022548 hypothetical protein; Provisional; Region: PRK08999 216595022549 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 216595022550 active site 216595022551 8-oxo-dGMP binding site [chemical binding]; other site 216595022552 nudix motif; other site 216595022553 metal binding site [ion binding]; metal-binding site 216595022554 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 216595022555 thiamine phosphate binding site [chemical binding]; other site 216595022556 active site 216595022557 pyrophosphate binding site [ion binding]; other site 216595022560 PS00893 mutT domain signature. 216595022561 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group...; Region: OAT; cd02152 216595022562 heterotetramer interface [polypeptide binding]; other site 216595022563 active site pocket [active] 216595022564 cleavage site 216595022566 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK13103 216595022567 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595022568 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 216595022569 SEC-C motif; Region: SEC-C; cl12132 216595022575 Protein of unknown function (DUF721); Region: DUF721; cl02324 216595022576 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 216595022578 PS00017 ATP/GTP-binding site motif A (P-loop). 216595022579 Cache domain; Region: Cache_1; pfam02743 216595022580 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 216595022581 dimerization interface [polypeptide binding]; other site 216595022582 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595022583 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595022584 2 probable transmembrane helices predicted for PFLU4936 by TMHMM2.0 at aa 7-29 and 279-301 216595022588 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 216595022589 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 216595022590 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 216595022591 putative active site [active] 216595022592 putative substrate binding site [chemical binding]; other site 216595022593 putative cosubstrate binding site; other site 216595022594 catalytic site [active] 216595022597 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 216595022598 exonuclease I; Provisional; Region: sbcB; PRK11779 216595022599 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 216595022600 active site 216595022601 substrate binding site [chemical binding]; other site 216595022602 catalytic site [active] 216595022603 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 216595022606 RDD family; Region: RDD; cl00746 216595022608 1 probable transmembrane helix predicted for PFLU4941 by TMHMM2.0 at aa 97-119 216595022609 PS00107 Protein kinases ATP-binding region signature. 216595022610 Integral membrane protein DUF95; Region: DUF95; cl00572 216595022611 6 probable transmembrane helices predicted for PFLU4942 by TMHMM2.0 at aa 104-126, 176-198, 203-225, 229-251, 271-290 and 295-317 216595022613 PS00922 Prokaryotic transglycosylases signature. 216595022614 5 probable transmembrane helices predicted for PFLU4943 by TMHMM2.0 at aa 31-53, 154-176, 206-228, 249-271 and 346-368 216595022615 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 216595022616 2 probable transmembrane helices predicted for PFLU4944 by TMHMM2.0 at aa 5-24 and 254-276 216595022617 MoxR-like ATPases [General function prediction only]; Region: COG0714 216595022618 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595022619 Walker A motif; other site 216595022620 ATP binding site [chemical binding]; other site 216595022621 Walker B motif; other site 216595022622 arginine finger; other site 216595022624 PS00017 ATP/GTP-binding site motif A (P-loop). 216595022625 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 216595022626 Protein of unknown function DUF58; Region: DUF58; pfam01882 216595022627 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 216595022628 metal ion-dependent adhesion site (MIDAS); other site 216595022629 2 probable transmembrane helices predicted for PFLU4946 by TMHMM2.0 at aa 7-29 and 34-52 216595022631 PilZ domain; Region: PilZ; cl01260 216595022632 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595022633 pyruvate kinase; Provisional; Region: PRK05826 216595022634 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 216595022635 domain interfaces; other site 216595022636 active site 216595022638 PS00110 Pyruvate kinase active site signature. 216595022640 enoyl-CoA hydratase; Provisional; Region: PRK06688 216595022641 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 216595022642 substrate binding site [chemical binding]; other site 216595022643 oxyanion hole (OAH) forming residues; other site 216595022644 trimer interface [polypeptide binding]; other site 216595022645 tellurium resistance terB-like protein; Region: terB_like; cl11965 216595022647 1 probable transmembrane helix predicted for PFLU4950 by TMHMM2.0 at aa 97-119 216595022648 hypothetical protein; Provisional; Region: PRK05713 216595022649 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216595022650 catalytic loop [active] 216595022651 iron binding site [ion binding]; other site 216595022652 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194 216595022653 FAD binding pocket [chemical binding]; other site 216595022654 FAD binding motif [chemical binding]; other site 216595022655 phosphate binding motif [ion binding]; other site 216595022656 beta-alpha-beta structure motif; other site 216595022657 NAD binding pocket [chemical binding]; other site 216595022661 putative fumarate hydratase; Provisional; Region: PRK15392 216595022662 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 216595022663 Fumarase C-terminus; Region: Fumerase_C; cl00795 216595022666 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 216595022667 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595022668 dimer interface [polypeptide binding]; other site 216595022669 phosphorylation site [posttranslational modification] 216595022670 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595022671 ATP binding site [chemical binding]; other site 216595022672 Mg2+ binding site [ion binding]; other site 216595022673 G-X-G motif; other site 216595022674 1 probable transmembrane helix predicted for PFLU4953 by TMHMM2.0 at aa 71-90 216595022677 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 216595022678 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595022679 active site 216595022680 phosphorylation site [posttranslational modification] 216595022681 intermolecular recognition site; other site 216595022682 dimerization interface [polypeptide binding]; other site 216595022683 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595022684 Walker A motif; other site 216595022685 ATP binding site [chemical binding]; other site 216595022686 Walker B motif; other site 216595022687 arginine finger; other site 216595022688 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 216595022691 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 216595022692 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 216595022693 PS00688 Sigma-54 interaction domain C-terminal part signature. 216595022695 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 216595022696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595022697 putative substrate translocation pore; other site 216595022699 11 probable transmembrane helices predicted for PFLU4955 by TMHMM2.0 at aa 64-86, 99-118, 122-144, 164-186, 196-218, 249-271, 286-308, 315-337, 341-363, 376-398 and 408-425 216595022700 PS00216 Sugar transport proteins signature 1. 216595022701 PS00217 Sugar transport proteins signature 2. 216595022702 PS00216 Sugar transport proteins signature 1. 216595022703 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 216595022704 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 216595022705 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 216595022706 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 216595022709 PS00107 Protein kinases ATP-binding region signature. 216595022711 Flavin Reductases; Region: FlaRed; cl00801 216595022712 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 216595022714 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 216595022715 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595022716 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216595022718 PS00041 Bacterial regulatory proteins, araC family signature. 216595022720 sensor protein RstB; Provisional; Region: PRK10604 216595022721 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595022722 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595022723 ATP binding site [chemical binding]; other site 216595022724 Mg2+ binding site [ion binding]; other site 216595022725 G-X-G motif; other site 216595022729 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216595022730 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595022731 active site 216595022732 phosphorylation site [posttranslational modification] 216595022733 intermolecular recognition site; other site 216595022734 dimerization interface [polypeptide binding]; other site 216595022735 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 216595022736 DNA binding site [nucleotide binding] 216595022739 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 216595022741 Dehydratase family; Region: ILVD_EDD; cl00340 216595022742 6-phosphogluconate dehydratase; Region: edd; TIGR01196 216595022744 PS00887 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 2. 216595022745 PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1. 216595022746 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595022747 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 216595022748 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 216595022749 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 216595022751 PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. 216595022753 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 216595022754 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216595022755 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 216595022758 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 216595022759 FecR protein; Region: FecR; pfam04773 216595022760 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 216595022762 Secretin and TonB N terminus short domain; Region: STN; cl06624 216595022763 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 216595022764 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216595022765 N-terminal plug; other site 216595022766 ligand-binding site [chemical binding]; other site 216595022767 1 probable transmembrane helix predicted for PFLU4968 by TMHMM2.0 at aa 12-34 216595022771 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 216595022772 heme binding pocket [chemical binding]; other site 216595022773 heme ligand [chemical binding]; other site 216595022775 Protein of unknown function (DUF454); Region: DUF454; cl01063 216595022776 2 probable transmembrane helices predicted for PFLU4970 by TMHMM2.0 at aa 12-34 and 106-123 216595022778 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595022779 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595022780 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595022781 2 probable transmembrane helices predicted for PFLU4971 by TMHMM2.0 at aa 15-37 and 366-388 216595022786 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a beta-...; Region: Arsenite_oxidase; cd02135 216595022787 putative FMN binding site [chemical binding]; other site 216595022789 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 216595022791 PS00190 Cytochrome c family heme-binding site signature. 216595022792 PS00190 Cytochrome c family heme-binding site signature. 216595022793 Imelysin; Region: Peptidase_M75; cl09159 216595022794 Protein of unknown function (DUF1513); Region: DUF1513; pfam07433 216595022796 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 216595022797 1 probable transmembrane helix predicted for PFLU4976 by TMHMM2.0 at aa 7-29 216595022799 multidrug efflux protein; Reviewed; Region: PRK09579 216595022800 Protein export membrane protein; Region: SecD_SecF; cl14618 216595022802 12 probable transmembrane helices predicted for PFLU4977 by TMHMM2.0 at aa 12-30, 333-355, 357-379, 383-405, 430-452, 467-489, 525-547, 844-866, 873-895, 900-922, 943-965 and 980-1002 216595022803 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 216595022804 1 probable transmembrane helix predicted for PFLU4978 by TMHMM2.0 at aa 46-68 216595022807 multidrug efflux protein; Reviewed; Region: PRK09579 216595022808 Protein export membrane protein; Region: SecD_SecF; cl14618 216595022810 12 probable transmembrane helices predicted for PFLU4979 by TMHMM2.0 at aa 7-29, 333-355, 357-379, 383-405, 430-452, 467-489, 520-542, 843-865, 872-894, 899-921, 942-964 and 979-1001 216595022811 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 216595022812 1 probable transmembrane helix predicted for PFLU4980 by TMHMM2.0 at aa 5-24 216595022813 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 216595022815 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 216595022816 S-adenosylmethionine binding site [chemical binding]; other site 216595022818 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595022819 dimer interface [polypeptide binding]; other site 216595022820 phosphorylation site [posttranslational modification] 216595022821 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595022822 ATP binding site [chemical binding]; other site 216595022823 Mg2+ binding site [ion binding]; other site 216595022824 G-X-G motif; other site 216595022828 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216595022829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595022830 active site 216595022831 phosphorylation site [posttranslational modification] 216595022832 intermolecular recognition site; other site 216595022833 dimerization interface [polypeptide binding]; other site 216595022834 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 216595022835 DNA binding site [nucleotide binding] 216595022838 Sulfatase; Region: Sulfatase; cl10460 216595022839 5 probable transmembrane helices predicted for PFLU4985 by TMHMM2.0 at aa 59-81, 96-118, 131-153, 180-202 and 223-240 216595022841 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 216595022842 active site 216595022843 6 probable transmembrane helices predicted for PFLU4986 by TMHMM2.0 at aa 13-35, 71-93, 100-122, 155-172, 184-201 and 211-230 216595022845 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 216595022846 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 216595022847 ring oligomerisation interface [polypeptide binding]; other site 216595022848 ATP/Mg binding site [chemical binding]; other site 216595022849 stacking interactions; other site 216595022850 hinge regions; other site 216595022852 PS00296 Chaperonins cpn60 signature. 216595022853 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 216595022854 oligomerisation interface [polypeptide binding]; other site 216595022855 mobile loop; other site 216595022856 roof hairpin; other site 216595022858 PS00681 Chaperonins cpn10 signature. 216595022859 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 216595022861 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 216595022862 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 216595022863 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 216595022865 Protein of unknown function, DUF481; Region: DUF481; cl01213 216595022866 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 216595022867 DNA binding site [nucleotide binding] 216595022868 active site 216595022870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 216595022871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 216595022872 14 probable transmembrane helices predicted for PFLU4993 by TMHMM2.0 at aa 20-42, 52-69, 89-108, 113-130, 151-173, 188-210, 231-253, 276-295, 315-337, 352-374, 379-401, 411-433, 446-468 and 473-495 216595022874 prolyl-tRNA synthetase; Provisional; Region: PRK09194 216595022875 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779 216595022876 dimer interface [polypeptide binding]; other site 216595022877 motif 1; other site 216595022878 active site 216595022879 motif 2; other site 216595022880 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334 216595022881 putative deacylase active site [active] 216595022882 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 216595022883 active site 216595022884 motif 3; other site 216595022885 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861 216595022886 anticodon binding site; other site 216595022888 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 216595022891 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595022892 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 216595022893 active site 216595022894 DNA polymerase IV; Validated; Region: PRK02406 216595022895 DNA binding site [nucleotide binding] 216595022897 Predicted integral membrane protein [Function unknown]; Region: COG0392 216595022898 Uncharacterized conserved protein [Function unknown]; Region: COG2898 216595022899 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 216595022900 14 probable transmembrane helices predicted for PFLU4997 by TMHMM2.0 at aa 35-57, 74-96, 111-133, 154-176, 186-208, 238-260, 270-301, 314-336, 351-373, 394-416, 421-440, 447-466, 476-498 and 519-541 216595022904 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 216595022905 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 216595022906 1 probable transmembrane helix predicted for PFLU4998 by TMHMM2.0 at aa 5-27 216595022908 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 216595022909 DHH family; Region: DHH; pfam01368 216595022910 DHHA1 domain; Region: DHHA1; pfam02272 216595022913 YaeQ protein; Region: YaeQ; cl01913 216595022915 CoA-transferase family III; Region: CoA_transf_3; cl00778 216595022917 conserved hypothetical protein; Region: TIGR02285 216595022918 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595022919 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 216595022920 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 216595022921 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants...; Region: Thr-synth_2; cd01560 216595022922 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595022923 catalytic residue [active] 216595022925 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 216595022926 homoserine dehydrogenase; Provisional; Region: PRK06349 216595022927 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595022928 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 216595022929 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 216595022932 PS01042 Homoserine dehydrogenase signature. 216595022934 PS00318 Hydroxymethylglutaryl-coenzyme A reductases signature 2. 216595022935 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 216595022936 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide...; Region: DsbA_DsbC_DsbG; cd03020 216595022937 dimerization domain [polypeptide binding]; other site 216595022938 dimer interface [polypeptide binding]; other site 216595022939 catalytic residues [active] 216595022940 PS00194 Thioredoxin family active site. 216595022941 1 probable transmembrane helix predicted for PFLU5007 by TMHMM2.0 at aa 28-50 216595022942 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 216595022943 N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid...; Region: INT_XerDC; cd00798 216595022944 Int/Topo IB signature motif; other site 216595022945 active site 216595022948 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 216595022950 PS01015 Ribosomal protein L19 signature. 216595022951 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 216595022953 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 216595022954 RimM N-terminal domain; Region: RimM; pfam01782 216595022955 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 216595022958 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 216595022960 signal recognition particle protein; Provisional; Region: PRK10867 216595022961 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 216595022962 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 216595022963 P loop; other site 216595022964 GTP binding site [chemical binding]; other site 216595022965 Signal peptide binding domain; Region: SRP_SPB; pfam02978 216595022968 PS00300 SRP54-type proteins GTP-binding domain signature. 216595022969 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 216595022970 PS00017 ATP/GTP-binding site motif A (P-loop). 216595022972 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 216595022973 8 probable transmembrane helices predicted for PFLU5014 by TMHMM2.0 at aa 4-26, 39-61, 66-88, 95-117, 132-154, 180-202, 207-229 and 242-259 216595022975 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 216595022976 Domain of unknown function DUF21; Region: DUF21; pfam01595 216595022977 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 216595022978 Transporter associated domain; Region: CorC_HlyC; cl08393 216595022979 4 probable transmembrane helices predicted for PFLU5015 by TMHMM2.0 at aa 4-26, 59-81, 86-108 and 115-137 216595022983 metabolite-proton symporter; Region: 2A0106; TIGR00883 216595022984 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595022985 putative substrate translocation pore; other site 216595022987 11 probable transmembrane helices predicted for PFLU5016 by TMHMM2.0 at aa 36-58, 68-90, 99-121, 170-192, 199-221, 254-276, 289-311, 321-340, 347-369, 379-401 and 408-430 216595022988 PS00216 Sugar transport proteins signature 1. 216595022989 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 216595022990 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595022991 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 216595022993 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 216595022994 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 216595022996 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 216595022997 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 216595022998 trimer interface [polypeptide binding]; other site 216595022999 putative metal binding site [ion binding]; other site 216595023004 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 216595023005 putative active site [active] 216595023006 putative CoA binding site [chemical binding]; other site 216595023007 nudix motif; other site 216595023008 metal binding site [ion binding]; metal-binding site 216595023010 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 216595023011 nudix motif; other site 216595023013 PS00893 mutT domain signature. 216595023014 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 216595023016 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 216595023017 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595023018 DNA-binding site [nucleotide binding]; DNA binding site 216595023019 UTRA domain; Region: UTRA; cl01230 216595023021 PS00043 Bacterial regulatory proteins, gntR family signature. 216595023023 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 216595023024 active site 216595023025 dimer interface [polypeptide binding]; other site 216595023027 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 216595023028 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 216595023029 dimer interface [polypeptide binding]; other site 216595023030 active site 216595023031 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 216595023032 dimer interface [polypeptide binding]; other site 216595023033 active site 216595023036 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162 216595023037 HPr interaction site; other site 216595023038 glycerol kinase (GK) interaction site [polypeptide binding]; other site 216595023039 active site 216595023040 phosphorylation site [posttranslational modification] 216595023041 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 216595023042 dimerization domain swap beta strand [polypeptide binding]; other site 216595023043 regulatory protein interface [polypeptide binding]; other site 216595023044 active site 216595023045 regulatory phosphorylation site [posttranslational modification]; other site 216595023046 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 216595023047 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 216595023048 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 216595023049 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 216595023051 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 216595023052 PS00371 PTS EIIA domains phosphorylation site signature 1. 216595023054 PS00369 PTS HPR component histidine phosphorylation site signature. 216595023058 PS00742 PEP-utilizing enzymes signature 2. 216595023059 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 216595023060 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 216595023061 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 216595023062 active site turn [active] 216595023063 phosphorylation site [posttranslational modification] 216595023064 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 216595023065 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cl00164 216595023066 12 probable transmembrane helices predicted for PFLU5028 by TMHMM2.0 at aa 12-30, 45-67, 72-89, 94-113, 134-156, 166-188, 195-217, 232-249, 262-280, 285-307, 314-332 and 337-359 216595023069 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 216595023070 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 216595023071 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 216595023073 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 216595023074 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 216595023075 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203 216595023076 dimerization interface [polypeptide binding]; other site 216595023077 ATP binding site [chemical binding]; other site 216595023078 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204 216595023079 dimerization interface [polypeptide binding]; other site 216595023080 ATP binding site [chemical binding]; other site 216595023081 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 216595023082 putative active site [active] 216595023083 catalytic triad [active] 216595023087 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 216595023088 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595023089 substrate binding pocket [chemical binding]; other site 216595023090 membrane-bound complex binding site; other site 216595023091 hinge residues; other site 216595023092 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 216595023093 N-acetyl-D-glucosamine binding site [chemical binding]; other site 216595023094 catalytic residue [active] 216595023095 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595023098 PS00922 Prokaryotic transglycosylases signature. 216595023099 1 probable transmembrane helix predicted for PFLU5036 by TMHMM2.0 at aa 68-90 216595023100 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162 216595023101 HPr interaction site; other site 216595023102 glycerol kinase (GK) interaction site [polypeptide binding]; other site 216595023103 active site 216595023104 phosphorylation site [posttranslational modification] 216595023105 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 216595023106 dimerization domain swap beta strand [polypeptide binding]; other site 216595023107 regulatory protein interface [polypeptide binding]; other site 216595023108 active site 216595023109 regulatory phosphorylation site [posttranslational modification]; other site 216595023110 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 216595023111 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 216595023112 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 216595023113 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 216595023115 PS00742 PEP-utilizing enzymes signature 2. 216595023119 PS00012 Phosphopantetheine attachment site. 216595023120 PS00369 PTS HPR component histidine phosphorylation site signature. 216595023122 PS00371 PTS EIIA domains phosphorylation site signature 1. 216595023124 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel beta-...; Region: Maltoporin-like; cd01346 216595023125 trimer interface; other site 216595023126 sugar binding site [chemical binding]; other site 216595023128 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 216595023129 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 216595023131 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 216595023132 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 216595023133 active site turn [active] 216595023134 phosphorylation site [posttranslational modification] 216595023135 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 216595023137 PS00017 ATP/GTP-binding site motif A (P-loop). 216595023139 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 216595023140 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595023141 DNA-binding site [nucleotide binding]; DNA binding site 216595023142 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 216595023143 UTRA domain; Region: UTRA; cl01230 216595023146 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 216595023148 GMP synthase; Reviewed; Region: guaA; PRK00074 216595023149 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 216595023150 AMP/PPi binding site [chemical binding]; other site 216595023151 candidate oxyanion hole; other site 216595023152 catalytic triad [active] 216595023153 potential glutamine specificity residues [chemical binding]; other site 216595023154 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 216595023155 ATP Binding subdomain [chemical binding]; other site 216595023156 Ligand Binding sites [chemical binding]; other site 216595023157 Dimerization subdomain; other site 216595023161 PS00442 Glutamine amidotransferases class-I active site. 216595023162 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 216595023163 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 216595023164 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 216595023165 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 216595023166 active site 216595023168 PS00487 IMP dehydrogenase / GMP reductase signature. 216595023170 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 216595023172 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595023173 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595023174 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 216595023175 dimerization interface [polypeptide binding]; other site 216595023176 substrate binding pocket [chemical binding]; other site 216595023178 PS00044 Bacterial regulatory proteins, lysR family signature. 216595023180 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 216595023181 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489 216595023182 generic binding surface II; other site 216595023183 generic binding surface I; other site 216595023186 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 216595023187 Peptidase family M23; Region: Peptidase_M23; pfam01551 216595023189 2-isopropylmalate synthase; Validated; Region: PRK03739 216595023190 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 216595023191 active site 216595023192 catalytic residues [active] 216595023193 metal binding site [ion binding]; metal-binding site 216595023194 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 216595023195 PS00815 Alpha-isopropylmalate and homocitrate synthases signature 1. 216595023197 PS00816 Alpha-isopropylmalate and homocitrate synthases signature 2. 216595023199 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 216595023200 Predicted amidohydrolase [General function prediction only]; Region: COG0388 216595023201 putative active site [active] 216595023202 catalytic triad [active] 216595023203 multimer interface [polypeptide binding]; other site 216595023204 dimer interface [polypeptide binding]; other site 216595023206 methionine aminotransferase; Validated; Region: PRK09082 216595023207 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216595023208 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595023209 homodimer interface [polypeptide binding]; other site 216595023210 catalytic residue [active] 216595023212 GTP-binding protein Der; Reviewed; Region: PRK00093 216595023213 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894 216595023214 G1 box; other site 216595023215 GTP/Mg2+ binding site [chemical binding]; other site 216595023216 Switch I region; other site 216595023217 G2 box; other site 216595023218 Switch II region; other site 216595023219 G3 box; other site 216595023220 G4 box; other site 216595023221 G5 box; other site 216595023222 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 216595023223 G1 box; other site 216595023224 GTP/Mg2+ binding site [chemical binding]; other site 216595023225 Switch I region; other site 216595023226 G2 box; other site 216595023227 G3 box; other site 216595023228 Switch II region; other site 216595023229 G4 box; other site 216595023230 G5 box; other site 216595023232 PS00017 ATP/GTP-binding site motif A (P-loop). 216595023234 PS00017 ATP/GTP-binding site motif A (P-loop). 216595023235 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 216595023236 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 216595023237 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 216595023238 active site 216595023241 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595023242 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 216595023243 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 216595023244 1 probable transmembrane helix predicted for PFLU5055 by TMHMM2.0 at aa 15-37 216595023245 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 216595023246 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 216595023247 dimer interface [polypeptide binding]; other site 216595023248 motif 1; other site 216595023249 active site 216595023250 motif 2; other site 216595023251 motif 3; other site 216595023252 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 216595023253 anticodon binding site; other site 216595023255 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216595023257 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 216595023258 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 216595023260 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 216595023261 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 216595023262 cytoskeletal protein RodZ; Provisional; Region: PRK10856 216595023263 1 probable transmembrane helix predicted for PFLU5058 by TMHMM2.0 at aa 111-133 216595023264 PS00716 Sigma-70 factors family signature 2. 216595023266 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 216595023267 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 216595023268 binding surface 216595023269 TPR motif; other site 216595023270 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 216595023271 binding surface 216595023272 TPR motif; other site 216595023277 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595023278 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 216595023279 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 216595023280 FeS/SAM binding site; other site 216595023282 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 216595023283 active site 216595023284 multimer interface [polypeptide binding]; other site 216595023286 PS00469 Nucleoside diphosphate kinases active site. 216595023287 Protein of unknown function (DUF528); Region: DUF528; cl01123 216595023289 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 216595023291 chaperone protein HscA; Provisional; Region: hscA; PRK05183 216595023292 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 216595023294 PS01036 Heat shock hsp70 proteins family signature 3. 216595023295 PS00329 Heat shock hsp70 proteins family signature 2. 216595023296 PS01036 Heat shock hsp70 proteins family signature 3. 216595023297 PS00297 Heat shock hsp70 proteins family signature 1. 216595023298 co-chaperone HscB; Provisional; Region: hscB; PRK00294 216595023299 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 216595023300 HSP70 interaction site [polypeptide binding]; other site 216595023301 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 216595023304 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 216595023305 PS01152 Hypothetical hesB/yadR/yfhF family signature. 216595023307 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 216595023308 trimerization site [polypeptide binding]; other site 216595023309 active site 216595023311 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 216595023312 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 216595023313 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216595023314 catalytic residue [active] 216595023316 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 216595023317 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595023318 Rrf2 family protein; Region: rrf2_super; TIGR00738 216595023320 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 216595023321 serine O-acetyltransferase; Region: cysE; TIGR01172 216595023322 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354 216595023323 trimer interface [polypeptide binding]; other site 216595023324 active site 216595023325 substrate binding site [chemical binding]; other site 216595023326 CoA binding site [chemical binding]; other site 216595023331 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 216595023332 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 216595023334 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 216595023335 active site 216595023336 dimerization interface [polypeptide binding]; other site 216595023338 PS00629 Inositol monophosphatase family signature 1. 216595023339 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595023340 PS00630 Inositol monophosphatase family signature 2. 216595023342 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 216595023344 1 probable transmembrane helix predicted for PFLU5073 by TMHMM2.0 at aa 13-35 216595023345 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 216595023346 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 216595023347 Protein export membrane protein; Region: SecD_SecF; cl14618 216595023350 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 216595023351 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 216595023352 Protein export membrane protein; Region: SecD_SecF; cl14618 216595023354 PS00132 Zinc carboxypeptidases, zinc-binding region 1 signature. 216595023355 PS00017 ATP/GTP-binding site motif A (P-loop). 216595023357 Preprotein translocase subunit; Region: YajC; cl00806 216595023359 1 probable transmembrane helix predicted for PFLU5076 by TMHMM2.0 at aa 20-42 216595023360 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 216595023362 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 216595023363 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 216595023365 PFI-11 216595023366 integrase; Provisional; Region: PRK09692 216595023367 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 216595023368 active site 216595023369 Int/Topo IB signature motif; other site 216595023371 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 216595023373 Ion channel; Region: Ion_trans_2; cl11596 216595023375 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595023376 ABC transporter signature motif; other site 216595023377 Walker B; other site 216595023378 D-loop; other site 216595023379 H-loop/switch region; other site 216595023380 PS00017 ATP/GTP-binding site motif A (P-loop). 216595023381 PS00017 ATP/GTP-binding site motif A (P-loop). 216595023382 Response regulator receiver domain; Region: Response_reg; pfam00072 216595023383 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595023384 active site 216595023385 phosphorylation site [posttranslational modification] 216595023386 intermolecular recognition site; other site 216595023387 dimerization interface [polypeptide binding]; other site 216595023389 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 216595023390 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595023391 active site 216595023392 phosphorylation site [posttranslational modification] 216595023393 intermolecular recognition site; other site 216595023394 dimerization interface [polypeptide binding]; other site 216595023395 CheB methylesterase; Region: CheB_methylest; pfam01339 216595023398 CheD chemotactic sensory transduction; Region: CheD; cl00810 216595023399 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 216595023400 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 216595023401 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 216595023404 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 216595023405 putative CheA interaction surface; other site 216595023407 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 216595023408 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595023409 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595023410 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595023413 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 216595023414 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 216595023415 putative binding surface; other site 216595023416 active site 216595023417 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 216595023418 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595023419 ATP binding site [chemical binding]; other site 216595023420 Mg2+ binding site [ion binding]; other site 216595023421 G-X-G motif; other site 216595023422 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 216595023425 PS00017 ATP/GTP-binding site motif A (P-loop). 216595023428 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 216595023429 anti sigma factor interaction site; other site 216595023430 regulatory phosphorylation site [posttranslational modification]; other site 216595023432 Response regulator receiver domain; Region: Response_reg; pfam00072 216595023433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595023434 active site 216595023435 phosphorylation site [posttranslational modification] 216595023436 intermolecular recognition site; other site 216595023437 dimerization interface [polypeptide binding]; other site 216595023440 Cupin domain; Region: Cupin_2; cl09118 216595023442 LysE type translocator; Region: LysE; cl00565 216595023444 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 216595023446 Protein of unknown function (DUF3077); Region: DUF3077; pfam11275 216595023447 Low G+C content region (39.7%) 216595023448 PS00334 Myb DNA-binding domain repeat signature 2. 216595023449 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 216595023451 S-type Pyocin; Region: Pyocin_S; pfam06958 216595023452 Cytotoxic; Region: Cytotoxic; pfam09000 216595023455 Cloacin immunity protein; Region: Cloacin_immun; pfam03513 216595023457 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595023458 sensor protein QseC; Provisional; Region: PRK10337 216595023459 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595023460 dimer interface [polypeptide binding]; other site 216595023461 phosphorylation site [posttranslational modification] 216595023462 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595023463 ATP binding site [chemical binding]; other site 216595023464 Mg2+ binding site [ion binding]; other site 216595023465 G-X-G motif; other site 216595023468 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 216595023469 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595023470 active site 216595023471 phosphorylation site [posttranslational modification] 216595023472 intermolecular recognition site; other site 216595023473 dimerization interface [polypeptide binding]; other site 216595023474 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 216595023475 DNA binding site [nucleotide binding] 216595023478 PS00217 Sugar transport proteins signature 2. 216595023479 Uncharacterized conserved protein [Function unknown]; Region: COG5591 216595023480 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 216595023482 4 probable transmembrane helices predicted for PFLU5113 by TMHMM2.0 at aa 13-30, 37-59, 95-117 and 137-159 216595023483 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 216595023484 Asp-box motif; other site 216595023487 6 probable transmembrane helices predicted for PFLU5115 by TMHMM2.0 at aa 5-27, 32-54, 61-80, 90-112, 125-147 and 167-189 216595023488 Sulfatase; Region: Sulfatase; cl10460 216595023489 5 probable transmembrane helices predicted for PFLU5116 by TMHMM2.0 at aa 13-35, 55-73, 86-105, 139-161 and 177-199 216595023491 Cytochrome c; Region: Cytochrom_C; cl11414 216595023493 PS00190 Cytochrome c family heme-binding site signature. 216595023494 1 probable transmembrane helix predicted for PFLU5117 by TMHMM2.0 at aa 21-43 216595023495 Response regulator receiver domain; Region: Response_reg; pfam00072 216595023496 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595023497 active site 216595023498 phosphorylation site [posttranslational modification] 216595023499 intermolecular recognition site; other site 216595023500 dimerization interface [polypeptide binding]; other site 216595023502 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 216595023503 heme binding pocket [chemical binding]; other site 216595023504 heme ligand [chemical binding]; other site 216595023506 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 216595023507 GAF domain; Region: GAF; cl00853 216595023508 Phytochrome region; Region: PHY; pfam00360 216595023509 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595023510 dimer interface [polypeptide binding]; other site 216595023511 phosphorylation site [posttranslational modification] 216595023512 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595023513 ATP binding site [chemical binding]; other site 216595023514 Mg2+ binding site [ion binding]; other site 216595023515 G-X-G motif; other site 216595023521 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 216595023522 metal binding site [ion binding]; metal-binding site 216595023523 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 216595023524 putative active site [active] 216595023525 putative metal binding site [ion binding]; other site 216595023526 Low G+C content region (43.86%) 216595023527 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 216595023529 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216595023530 PAS fold; Region: PAS_3; pfam08447 216595023531 putative active site [active] 216595023532 heme pocket [chemical binding]; other site 216595023533 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216595023534 metal binding site [ion binding]; metal-binding site 216595023535 active site 216595023536 I-site; other site 216595023539 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 216595023540 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595023541 substrate binding pocket [chemical binding]; other site 216595023542 membrane-bound complex binding site; other site 216595023543 hinge residues; other site 216595023545 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 216595023546 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 216595023547 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595023548 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595023549 dimerization interface [polypeptide binding]; other site 216595023551 PS00044 Bacterial regulatory proteins, lysR family signature. 216595023553 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 216595023554 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 216595023555 inhibitor-cofactor binding pocket; inhibition site 216595023556 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595023557 catalytic residue [active] 216595023559 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 216595023560 Phd_YefM; Region: PhdYeFM; cl09153 216595023562 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 216595023564 5 probable transmembrane helices predicted for PFLU5133 by TMHMM2.0 at aa 10-29, 36-58, 62-79, 92-114 and 129-151 216595023565 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 216595023566 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216595023567 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595023568 homodimer interface [polypeptide binding]; other site 216595023569 catalytic residue [active] 216595023571 UbiA prenyltransferase family; Region: UbiA; cl00337 216595023573 PS00943 UbiA prenyltransferase family signature. 216595023574 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 216595023576 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 216595023577 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 216595023578 Subunit I/III interface [polypeptide binding]; other site 216595023579 Subunit III/IV interface [polypeptide binding]; other site 216595023581 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 216595023582 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 216595023583 D-pathway; other site 216595023584 Putative ubiquinol binding site [chemical binding]; other site 216595023585 Low-spin heme (heme b) binding site [chemical binding]; other site 216595023586 Putative water exit pathway; other site 216595023587 Binuclear center (heme o3/CuB) [ion binding]; other site 216595023588 K-pathway; other site 216595023589 Putative proton exit pathway; other site 216595023591 PS00077 Heme-copper oxidase catalytic subunit, copper B binding region signature. 216595023592 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 216595023593 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 216595023594 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 216595023597 low G+C content region (49.77%) 216595023598 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 216595023600 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 216595023601 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 216595023602 heme-binding site [chemical binding]; other site 216595023603 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 216595023604 FAD binding pocket [chemical binding]; other site 216595023605 FAD binding motif [chemical binding]; other site 216595023606 phosphate binding motif [ion binding]; other site 216595023607 beta-alpha-beta structure motif; other site 216595023608 NAD binding pocket [chemical binding]; other site 216595023609 Heme binding pocket [chemical binding]; other site 216595023613 low G+C content region (37.83%) 216595023614 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 216595023615 GAF domain; Region: GAF; cl00853 216595023616 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595023617 Walker A motif; other site 216595023618 ATP binding site [chemical binding]; other site 216595023619 Walker B motif; other site 216595023622 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 216595023623 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 216595023624 PS00688 Sigma-54 interaction domain C-terminal part signature. 216595023626 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 216595023629 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595023630 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216595023631 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595023633 PS00041 Bacterial regulatory proteins, araC family signature. 216595023635 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 216595023636 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 216595023637 DNA binding residues [nucleotide binding] 216595023638 dimerization interface [polypeptide binding]; other site 216595023640 PS00622 Bacterial regulatory proteins, luxR family signature. 216595023642 PS00017 ATP/GTP-binding site motif A (P-loop). 216595023643 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 216595023645 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 216595023647 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 216595023648 homodimer interface [polypeptide binding]; other site 216595023649 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 216595023650 NAD binding site [chemical binding]; other site 216595023651 active site 216595023652 PS00017 ATP/GTP-binding site motif A (P-loop). 216595023654 PS00061 Short-chain dehydrogenases/reductases family signature. 216595023655 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216595023657 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 216595023658 intersubunit interface [polypeptide binding]; other site 216595023659 active site 216595023660 Zn2+ binding site [ion binding]; other site 216595023662 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 216595023664 PAS domain S-box; Region: sensory_box; TIGR00229 216595023665 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216595023666 putative active site [active] 216595023667 heme pocket [chemical binding]; other site 216595023669 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 216595023670 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 216595023671 DNA binding residues [nucleotide binding] 216595023673 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 216595023674 2 probable transmembrane helices predicted for PFLU5156 by TMHMM2.0 at aa 135-157 and 164-186 216595023675 dihydromonapterin reductase; Provisional; Region: PRK06483 216595023676 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 216595023677 NADP binding site [chemical binding]; other site 216595023678 substrate binding pocket [chemical binding]; other site 216595023679 active site 216595023681 PS00061 Short-chain dehydrogenases/reductases family signature. 216595023682 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 216595023683 homodecamer interface [polypeptide binding]; other site 216595023684 GTP cyclohydrolase I; Provisional; Region: PLN03044 216595023685 active site 216595023686 putative catalytic site residues [active] 216595023687 zinc binding site [ion binding]; other site 216595023688 GTP-CH-I/GFRP interaction surface; other site 216595023690 PS00859 GTP cyclohydrolase I signature 1. 216595023691 PS00860 GTP cyclohydrolase I signature 2. 216595023692 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 216595023693 active site 216595023695 Protein of unknown function (DUF1244); Region: DUF1244; cl01385 216595023697 PS00017 ATP/GTP-binding site motif A (P-loop). 216595023698 HopJ type III effector protein; Region: HopJ; pfam08888 216595023700 thioredoxin reductase; Provisional; Region: PRK10262 216595023701 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595023704 PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. 216595023705 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 216595023706 4 probable transmembrane helices predicted for PFLU5163 by TMHMM2.0 at aa 24-46, 67-89, 148-170 and 208-230 216595023708 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216595023709 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule...; Region: GT1_like_2; cd03814 216595023711 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 216595023712 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 216595023713 putative active site [active] 216595023714 putative FMN binding site [chemical binding]; other site 216595023715 putative substrate binding site [chemical binding]; other site 216595023716 putative catalytic residue [active] 216595023718 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340 216595023719 catalytic residues [active] 216595023720 dimer interface [polypeptide binding]; other site 216595023722 CreA protein; Region: CreA; cl01154 216595023724 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 216595023725 gamma-glutamyl kinase; Provisional; Region: PRK05429 216595023726 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 216595023727 nucleotide binding site [chemical binding]; other site 216595023728 homotetrameric interface [polypeptide binding]; other site 216595023729 putative phosphate binding site [ion binding]; other site 216595023730 putative allosteric binding site; other site 216595023731 PUA domain; Region: PUA; cl00607 216595023734 PS00902 Glutamate 5-kinase signature. 216595023735 GTPase CgtA; Reviewed; Region: obgE; PRK12298 216595023736 GTP1/OBG; Region: GTP1_OBG; pfam01018 216595023737 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 216595023738 G1 box; other site 216595023739 GTP/Mg2+ binding site [chemical binding]; other site 216595023740 Switch I region; other site 216595023741 G2 box; other site 216595023742 G3 box; other site 216595023743 Switch II region; other site 216595023744 G4 box; other site 216595023745 G5 box; other site 216595023747 PS00905 GTP1/OBG family signature. 216595023748 PS00017 ATP/GTP-binding site motif A (P-loop). 216595023750 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 216595023752 PS00831 Ribosomal protein L27 signature. 216595023753 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 216595023755 PS01169 Ribosomal protein L21 signature. 216595023756 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216595023757 octaprenyl diphosphate synthase; Provisional; Region: PRK10888 216595023758 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 216595023759 substrate binding pocket [chemical binding]; other site 216595023760 chain length determination region; other site 216595023761 substrate-Mg2+ binding site; other site 216595023762 catalytic residues [active] 216595023763 aspartate-rich region 1; other site 216595023764 active site lid residues [active] 216595023765 aspartate-rich region 2; other site 216595023767 PS00723 Polyprenyl synthetases signature 1. 216595023768 PS00444 Polyprenyl synthetases signature 2. 216595023769 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 216595023770 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 216595023771 PhnA protein; Region: PhnA; pfam03831 216595023774 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 216595023775 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 216595023776 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 216595023778 PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2. 216595023780 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 216595023781 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 216595023782 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 216595023783 dimerization interface [polypeptide binding]; other site 216595023784 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595023785 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595023786 2 probable transmembrane helices predicted for PFLU5176 by TMHMM2.0 at aa 15-37 and 286-308 216595023789 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 216595023790 dimer interface [polypeptide binding]; other site 216595023791 ligand binding site [chemical binding]; other site 216595023793 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 216595023794 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 216595023795 active site 216595023796 putative substrate binding pocket [chemical binding]; other site 216595023799 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 216595023800 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 216595023801 putative active site [active] 216595023804 gluconate transporter; Region: gntP; TIGR00791 216595023805 GntP family permease; Region: GntP_permease; cl15264 216595023807 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 216595023809 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 216595023810 Sulfate transporter family; Region: Sulfate_transp; cl00967 216595023811 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 216595023814 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595023815 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595023816 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216595023817 NAD(P) binding site [chemical binding]; other site 216595023818 active site 216595023820 PS00017 ATP/GTP-binding site motif A (P-loop). 216595023821 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595023822 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595023823 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595023824 dimerization interface [polypeptide binding]; other site 216595023827 PS00044 Bacterial regulatory proteins, lysR family signature. 216595023829 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595023830 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 216595023831 putative dimerization interface [polypeptide binding]; other site 216595023834 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 216595023835 ethanolamine permease; Region: 2A0305; TIGR00908 216595023837 PS00218 Amino acid permeases signature. 216595023838 kynureninase; Region: kynureninase; TIGR01814 216595023839 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 216595023840 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216595023841 catalytic residue [active] 216595023843 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 216595023844 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595023846 PS00519 Bacterial regulatory proteins, asnC family signature. 216595023848 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 216595023849 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 216595023850 dimer interface [polypeptide binding]; other site 216595023851 active site 216595023853 PS00083 Intradiol ring-cleavage dioxygenases signature. 216595023855 PS00017 ATP/GTP-binding site motif A (P-loop). 216595023856 Muconolactone delta-isomerase; Region: MIase; cl01992 216595023858 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 216595023859 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-...; Region: MLE; cd03318 216595023860 octamer interface [polypeptide binding]; other site 216595023861 active site 216595023863 PS00909 Mandelate racemase / muconate lactonizing enzyme family signature 2. 216595023865 PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1. 216595023866 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 216595023867 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595023868 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 216595023869 dimerizarion interface [polypeptide binding]; other site 216595023870 CrgA pocket; other site 216595023871 substrate binding pocket [chemical binding]; other site 216595023874 transcriptional regulator EutR; Provisional; Region: PRK10130 216595023876 PS00041 Bacterial regulatory proteins, araC family signature. 216595023878 anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228 216595023879 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 216595023880 iron-sulfur cluster [ion binding]; other site 216595023881 [2Fe-2S] cluster binding site [ion binding]; other site 216595023882 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 216595023883 putative alpha subunit interface [polypeptide binding]; other site 216595023884 putative active site [active] 216595023885 putative substrate binding site [chemical binding]; other site 216595023886 Fe binding site [ion binding]; other site 216595023888 PS00570 Bacterial ring hydroxylating dioxygenases alpha-subunit signature. 216595023890 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 216595023891 inter-subunit interface; other site 216595023893 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 216595023894 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216595023895 catalytic loop [active] 216595023896 iron binding site [ion binding]; other site 216595023897 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 216595023898 FAD binding pocket [chemical binding]; other site 216595023899 FAD binding motif [chemical binding]; other site 216595023900 phosphate binding motif [ion binding]; other site 216595023901 beta-alpha-beta structure motif; other site 216595023902 NAD binding pocket [chemical binding]; other site 216595023904 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 216595023907 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 216595023908 Amino acid permease; Region: AA_permease; pfam00324 216595023910 12 probable transmembrane helices predicted for PFLU5197 by TMHMM2.0 at aa 21-43, 47-69, 89-111, 121-143, 156-178, 201-223, 243-262, 294-316, 343-365, 369-391, 412-434 and 440-459 216595023911 PS00218 Amino acid permeases signature. 216595023912 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 216595023914 Putative cyclase; Region: Cyclase; cl00814 216595023916 Cupin domain; Region: Cupin_2; cl09118 216595023918 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595023919 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 216595023921 PS00895 3-hydroxyisobutyrate dehydrogenase signature. 216595023922 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 216595023923 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216595023924 tetrameric interface [polypeptide binding]; other site 216595023925 NAD binding site [chemical binding]; other site 216595023926 catalytic residues [active] 216595023928 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 216595023929 PS00070 Aldehyde dehydrogenases cysteine active site. 216595023930 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595023931 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595023932 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595023933 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595023934 dimerization interface [polypeptide binding]; other site 216595023937 Protein of unknown function (DUF3077); Region: DUF3077; pfam11275 216595023938 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 216595023939 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595023940 HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 216595023941 substrate binding pocket [chemical binding]; other site 216595023944 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 216595023945 EamA-like transporter family; Region: EamA; cl01037 216595023948 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 216595023949 active site 216595023950 iron coordination sites [ion binding]; other site 216595023951 substrate binding pocket [chemical binding]; other site 216595023953 putative outer membrane lipoprotein; Provisional; Region: PRK09967 216595023954 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216595023955 ligand binding site [chemical binding]; other site 216595023957 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595023958 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595023959 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216595023960 metal binding site [ion binding]; metal-binding site 216595023961 active site 216595023962 I-site; other site 216595023965 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 216595023966 Putative ATPase (DUF699); Region: DUF699; pfam05127 216595023967 PS00017 ATP/GTP-binding site motif A (P-loop). 216595023968 PS00024 Hemopexin domain signature. 216595023969 UvrD/REP helicase; Region: UvrD-helicase; cl14126 216595023970 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 216595023971 UvrD/REP helicase; Region: UvrD-helicase; cl14126 216595023972 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 216595023974 PS00017 ATP/GTP-binding site motif A (P-loop). 216595023975 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 216595023976 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 216595023978 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595023979 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595023980 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 216595023982 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 216595023983 Moco binding site; other site 216595023984 metal coordination site [ion binding]; other site 216595023986 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 216595023987 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 216595023989 PS00379 CDP-alcohol phosphatidyltransferases signature. 216595023990 ketol-acid reductoisomerase; Provisional; Region: PRK05479 216595023991 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595023992 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 216595023995 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 216595023996 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 216595023997 putative valine binding site [chemical binding]; other site 216595023998 dimer interface [polypeptide binding]; other site 216595023999 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 216595024001 PS00430 TonB-dependent receptor proteins signature 1. 216595024002 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466 216595024003 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 216595024004 PYR/PP interface [polypeptide binding]; other site 216595024005 dimer interface [polypeptide binding]; other site 216595024006 TPP binding site [chemical binding]; other site 216595024007 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 216595024008 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 216595024009 TPP-binding site [chemical binding]; other site 216595024010 dimer interface [polypeptide binding]; other site 216595024014 PS00044 Bacterial regulatory proteins, lysR family signature. 216595024015 Domain of unknown function, DUF446; Region: DUF446; cl01187 216595024018 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 216595024019 Transglycosylase; Region: Transgly; cl07896 216595024020 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 216595024022 PS00017 ATP/GTP-binding site motif A (P-loop). 216595024024 1 probable transmembrane helix predicted for PFLU5223 by TMHMM2.0 at aa 21-43 216595024025 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 216595024026 Predicted kinase [General function prediction only]; Region: COG0645 216595024027 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 216595024028 ATP-binding site [chemical binding]; other site 216595024029 Gluconate-6-phosphate binding site [chemical binding]; other site 216595024030 PS00017 ATP/GTP-binding site motif A (P-loop). 216595024031 secreted effector protein PipB; Provisional; Region: PRK15197 216595024032 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 216595024034 TfoX N-terminal domain; Region: TfoX_N; cl01167 216595024036 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 216595024037 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 216595024038 Walker A/P-loop; other site 216595024039 ATP binding site [chemical binding]; other site 216595024040 Q-loop/lid; other site 216595024041 ABC transporter signature motif; other site 216595024042 Walker B; other site 216595024043 D-loop; other site 216595024044 H-loop/switch region; other site 216595024046 PS00017 ATP/GTP-binding site motif A (P-loop). 216595024047 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 216595024048 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 216595024049 ABC-ATPase subunit interface; other site 216595024050 dimer interface [polypeptide binding]; other site 216595024051 putative PBP binding regions; other site 216595024053 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 216595024054 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 216595024055 putative hemin binding site; other site 216595024057 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467 216595024058 iron-sulfur cluster [ion binding]; other site 216595024059 [2Fe-2S] cluster binding site [ion binding]; other site 216595024061 Sugar fermentation stimulation protein; Region: SfsA; cl00647 216595024063 hypothetical protein; Validated; Region: PRK07682 216595024064 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216595024065 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595024066 homodimer interface [polypeptide binding]; other site 216595024067 catalytic residue [active] 216595024069 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595024070 PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 216595024071 PS00017 ATP/GTP-binding site motif A (P-loop). 216595024072 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 216595024074 PS01102 Prokaryotic dksA/traR C4-type zinc finger. 216595024075 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 216595024076 active site 216595024077 HIGH motif; other site 216595024078 nucleotide binding site [chemical binding]; other site 216595024079 Proline dehydrogenase; Region: Pro_dh; cl03282 216595024080 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 216595024081 KMSKS motif; other site 216595024083 2 probable transmembrane helices predicted for PFLU5235 by TMHMM2.0 at aa 7-26 and 30-49 216595024084 Sodium:solute symporter family; Region: SSF; cl00456 216595024085 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 216595024086 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 216595024087 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595024088 dimer interface [polypeptide binding]; other site 216595024089 phosphorylation site [posttranslational modification] 216595024090 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595024091 ATP binding site [chemical binding]; other site 216595024092 Mg2+ binding site [ion binding]; other site 216595024093 G-X-G motif; other site 216595024094 14 probable transmembrane helices predicted for PFLU5236 by TMHMM2.0 at aa 5-27, 42-64, 71-93, 113-135, 156-178, 188-210, 244-261, 276-298, 307-329, 333-355, 376-395, 400-422, 429-451 and 471-493 216595024098 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 216595024099 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595024100 active site 216595024101 phosphorylation site [posttranslational modification] 216595024102 intermolecular recognition site; other site 216595024103 dimerization interface [polypeptide binding]; other site 216595024104 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595024105 Walker A motif; other site 216595024106 ATP binding site [chemical binding]; other site 216595024107 Walker B motif; other site 216595024108 arginine finger; other site 216595024111 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 216595024112 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 216595024113 PS00688 Sigma-54 interaction domain C-terminal part signature. 216595024114 poly(A) polymerase; Region: pcnB; TIGR01942 216595024115 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 216595024116 active site 216595024117 NTP binding site [chemical binding]; other site 216595024118 metal binding triad [ion binding]; metal-binding site 216595024119 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 216595024120 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 216595024121 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595024123 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 216595024124 catalytic center binding site [active] 216595024125 ATP binding site [chemical binding]; other site 216595024127 PS00794 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. 216595024128 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 216595024129 oligomerization interface [polypeptide binding]; other site 216595024130 active site 216595024131 metal binding site [ion binding]; metal-binding site 216595024133 Pantoate-beta-alanine ligase; Region: PanC; cd00560 216595024134 pantoate--beta-alanine ligase; Region: panC; TIGR00018 216595024135 active site 216595024136 ATP-binding site [chemical binding]; other site 216595024137 pantoate-binding site; other site 216595024138 HXXH motif; other site 216595024140 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 216595024141 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 216595024142 active site 216595024143 dimer interface [polypeptide binding]; other site 216595024144 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 216595024145 dimer interface [polypeptide binding]; other site 216595024146 active site 216595024148 PS00765 Phosphoglucose isomerase signature 1. 216595024149 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595024150 PS00174 Phosphoglucose isomerase signature 2. 216595024151 acetyl-CoA synthetase; Provisional; Region: PRK00174 216595024152 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 216595024153 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 216595024155 PS00455 Putative AMP-binding domain signature. 216595024156 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 216595024157 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 216595024159 AsmA family; Region: AsmA; pfam05170 216595024160 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 216595024161 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 216595024162 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 216595024163 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 216595024164 1 probable transmembrane helix predicted for PFLU5247 by TMHMM2.0 at aa 9-31 216595024168 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 216595024169 periplasmic protein; Provisional; Region: PRK10568 216595024170 BON domain; Region: BON; cl02771 216595024171 BON domain; Region: BON; cl02771 216595024174 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 216595024175 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 216595024176 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 216595024177 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 216595024178 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 216595024179 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 216595024180 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 216595024181 putative nucleic acid binding region [nucleotide binding]; other site 216595024182 G-X-X-G motif; other site 216595024183 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472 216595024184 RNA binding site [nucleotide binding]; other site 216595024185 domain interface; other site 216595024193 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 216595024194 16S/18S rRNA binding site [nucleotide binding]; other site 216595024195 S13e-L30e interaction site [polypeptide binding]; other site 216595024196 25S rRNA binding site [nucleotide binding]; other site 216595024198 PS00362 Ribosomal protein S15 signature. 216595024199 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 216595024200 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573 216595024201 RNA binding site [nucleotide binding]; other site 216595024202 active site 216595024205 Ribosome-binding factor A; Region: RBFA; cl00542 216595024207 PS01319 Ribosome-binding factor A signature. 216595024208 translation initiation factor IF-2; Validated; Region: infB; PRK05306 216595024209 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 216595024210 translation initiation factor IF-2; Region: IF-2; TIGR00487 216595024211 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 216595024212 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 216595024213 G1 box; other site 216595024214 putative GEF interaction site [polypeptide binding]; other site 216595024215 GTP/Mg2+ binding site [chemical binding]; other site 216595024216 Switch I region; other site 216595024217 G2 box; other site 216595024218 G3 box; other site 216595024219 Switch II region; other site 216595024220 G4 box; other site 216595024221 G5 box; other site 216595024222 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 216595024223 Translation-initiation factor 2; Region: IF-2; pfam11987 216595024224 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 216595024226 PS01176 Initiation factor 2 signature. 216595024229 PS00017 ATP/GTP-binding site motif A (P-loop). 216595024233 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 216595024234 NusA N-terminal domain; Region: NusA_N; pfam08529 216595024235 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455 216595024236 RNA binding site [nucleotide binding]; other site 216595024237 homodimer interface [polypeptide binding]; other site 216595024238 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 216595024239 G-X-X-G motif; other site 216595024240 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 216595024241 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 216595024244 PS00037 Myb DNA-binding domain repeat signature 1. 216595024245 ribosome maturation protein RimP; Reviewed; Region: PRK00092 216595024246 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 216595024247 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 216595024248 Sm1 motif; other site 216595024249 D3 - B interaction site; other site 216595024250 D1 - D2 interaction site; other site 216595024251 Hfq - Hfq interaction site; other site 216595024252 RNA binding pocket [nucleotide binding]; other site 216595024253 Sm2 motif; other site 216595024255 Preprotein translocase SecG subunit; Region: SecG; cl09123 216595024257 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 216595024258 substrate binding site [chemical binding]; other site 216595024259 dimer interface [polypeptide binding]; other site 216595024260 catalytic triad [active] 216595024262 PS00171 Triosephosphate isomerase active site. 216595024263 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 216595024264 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802 216595024265 active site 216595024266 substrate binding site [chemical binding]; other site 216595024267 metal binding site [ion binding]; metal-binding site 216595024272 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 216595024273 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 216595024274 dihydropteroate synthase; Region: DHPS; TIGR01496 216595024275 substrate binding pocket [chemical binding]; other site 216595024276 dimer interface [polypeptide binding]; other site 216595024277 inhibitor binding site; inhibition site 216595024279 PS00793 Dihydropteroate synthase signature 2. 216595024280 PS00792 Dihydropteroate synthase signature 1. 216595024281 FtsH Extracellular; Region: FtsH_ext; pfam06480 216595024282 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 216595024283 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595024284 Walker A motif; other site 216595024285 ATP binding site [chemical binding]; other site 216595024286 Walker B motif; other site 216595024287 arginine finger; other site 216595024288 Peptidase family M41; Region: Peptidase_M41; pfam01434 216595024291 PS00674 AAA-protein family signature. 216595024292 PS00017 ATP/GTP-binding site motif A (P-loop). 216595024294 PS00017 ATP/GTP-binding site motif A (P-loop). 216595024295 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 216595024297 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 216595024299 PS01301 Uncharacterized protein family UPF0044 signature. 216595024300 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 216595024301 domain; Region: GreA_GreB_N; pfam03449 216595024302 C-term; Region: GreA_GreB; pfam01272 216595024304 PS00830 Prokaryotic transcription elongation factors signature 2. 216595024306 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 216595024307 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 216595024308 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 216595024309 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 216595024310 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 216595024311 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 216595024312 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 216595024313 IMP binding site; other site 216595024314 dimer interface [polypeptide binding]; other site 216595024315 interdomain contacts; other site 216595024316 partial ornithine binding site; other site 216595024318 PS00017 ATP/GTP-binding site motif A (P-loop). 216595024319 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 216595024321 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 216595024325 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 216595024326 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 216595024328 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595024329 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 216595024330 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 216595024331 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 216595024332 catalytic site [active] 216595024333 subunit interface [polypeptide binding]; other site 216595024335 PS00442 Glutamine amidotransferases class-I active site. 216595024337 dihydrodipicolinate reductase; Provisional; Region: PRK00048 216595024338 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595024339 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 216595024341 PS01298 Dihydrodipicolinate reductase signature. 216595024343 PS00017 ATP/GTP-binding site motif A (P-loop). 216595024344 chaperone protein DnaJ; Provisional; Region: PRK10767 216595024345 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 216595024346 HSP70 interaction site [polypeptide binding]; other site 216595024347 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 216595024348 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 216595024349 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 216595024352 PS00190 Cytochrome c family heme-binding site signature. 216595024353 PS00637 CXXCXGXG dnaJ domain signature. 216595024355 PS00636 Nt-dnaJ domain signature. 216595024356 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 216595024357 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 216595024359 PS01036 Heat shock hsp70 proteins family signature 3. 216595024360 PS00329 Heat shock hsp70 proteins family signature 2. 216595024361 PS00297 Heat shock hsp70 proteins family signature 1. 216595024362 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 216595024363 dimer interface [polypeptide binding]; other site 216595024364 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 216595024366 PS01071 grpE protein signature. 216595024367 recombination and repair protein; Provisional; Region: PRK10869 216595024368 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 216595024369 Walker A/P-loop; other site 216595024370 ATP binding site [chemical binding]; other site 216595024371 Q-loop/lid; other site 216595024372 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 216595024373 ABC transporter signature motif; other site 216595024374 Walker B; other site 216595024375 D-loop; other site 216595024376 H-loop/switch region; other site 216595024378 PS00017 ATP/GTP-binding site motif A (P-loop). 216595024379 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 216595024380 metal binding site 2 [ion binding]; metal-binding site 216595024381 putative DNA binding helix; other site 216595024382 metal binding site 1 [ion binding]; metal-binding site 216595024383 dimer interface [polypeptide binding]; other site 216595024384 structural Zn2+ binding site [ion binding]; other site 216595024386 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 216595024387 1 probable transmembrane helix predicted for PFLU5273 by TMHMM2.0 at aa 7-28 216595024388 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595024390 Uncharacterised protein family (UPF0125); Region: UPF0125; cl01096 216595024392 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 216595024393 putative coenzyme Q binding site [chemical binding]; other site 216595024395 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 216595024396 SmpB-tmRNA interface; other site 216595024398 PS01317 Protein smpB signature. 216595024399 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216595024400 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595024401 DNA-binding site [nucleotide binding]; DNA binding site 216595024402 FCD domain; Region: FCD; cl11656 216595024405 PS00043 Bacterial regulatory proteins, gntR family signature. 216595024406 glycolate transporter; Provisional; Region: PRK09695 216595024407 L-lactate permease; Region: Lactate_perm; cl00701 216595024408 16 probable transmembrane helices predicted for PFLU5278 by TMHMM2.0 at aa 10-32, 39-58, 73-95, 116-135, 139-161, 168-186, 191-213, 220-242, 252-269, 276-298, 308-330, 335-352, 381-403, 415-434, 444-466 and 541-563 216595024410 PS00043 Bacterial regulatory proteins, gntR family signature. 216595024411 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 216595024412 FAD binding domain; Region: FAD_binding_4; pfam01565 216595024413 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 216595024414 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 216595024418 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216595024419 PS00017 ATP/GTP-binding site motif A (P-loop). 216595024420 PFI-12 216595024421 integrase; Provisional; Region: PRK09692 216595024422 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 216595024423 active site 216595024424 Int/Topo IB signature motif; other site 216595024427 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 216595024428 multiple promoter invertase; Provisional; Region: mpi; PRK13413 216595024429 catalytic residues [active] 216595024430 catalytic nucleophile [active] 216595024431 Presynaptic Site I dimer interface [polypeptide binding]; other site 216595024432 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 216595024433 Synaptic Flat tetramer interface [polypeptide binding]; other site 216595024434 Synaptic Site I dimer interface [polypeptide binding]; other site 216595024435 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 216595024436 DNA-binding interface [nucleotide binding]; DNA binding site 216595024440 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 216595024442 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595024443 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 216595024445 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216595024446 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216595024448 PS01081 Bacterial regulatory proteins, tetR family signature. 216595024449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595024450 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 216595024451 putative substrate translocation pore; other site 216595024452 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595024453 13 probable transmembrane helices predicted for PFLU5296 by TMHMM2.0 at aa 20-42, 57-79, 86-108, 112-134, 147-169, 174-196, 209-227, 237-256, 276-298, 313-335, 342-361, 366-388 and 476-498 216595024455 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 216595024456 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216595024457 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595024459 choline dehydrogenase; Validated; Region: PRK02106 216595024460 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595024461 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 216595024463 PS00017 ATP/GTP-binding site motif A (P-loop). 216595024464 PS00623 GMC oxidoreductases signature 1. 216595024465 PS00624 GMC oxidoreductases signature 2. 216595024467 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 216595024468 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 216595024469 1 probable transmembrane helix predicted for PFLU5301 by TMHMM2.0 at aa 38-57 216595024471 PS01173 Lipolytic enzymes G-D-X-G family, putative histidine active site. 216595024472 PS01174 Lipolytic enzymes G-D-X-G family, putative serine active site. 216595024473 classical (c) SDRs; Region: SDR_c; cd05233 216595024474 NAD(P) binding site [chemical binding]; other site 216595024475 active site 216595024477 PS00061 Short-chain dehydrogenases/reductases family signature. 216595024478 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 216595024479 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 216595024480 catalytic residues [active] 216595024481 catalytic nucleophile [active] 216595024482 Recombinase; Region: Recombinase; pfam07508 216595024485 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 216595024486 ParB-like nuclease domain; Region: ParBc; cl02129 216595024487 RepB plasmid partitioning protein; Region: RepB; pfam07506 216595024490 ParB-like nuclease domain; Region: ParBc; cl02129 216595024491 RepB plasmid partitioning protein; Region: RepB; pfam07506 216595024493 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 216595024495 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 216595024497 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 216595024498 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 216595024499 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 216595024501 Nitrate and nitrite sensing; Region: NIT; pfam08376 216595024502 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595024503 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595024504 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595024505 2 probable transmembrane helices predicted for PFLU5309 by TMHMM2.0 at aa 25-44 and 314-336 216595024509 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 216595024510 synthetase active site [active] 216595024511 NTP binding site [chemical binding]; other site 216595024512 metal binding site [ion binding]; metal-binding site 216595024514 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 216595024515 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 216595024516 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595024517 active site 216595024518 phosphorylation site [posttranslational modification] 216595024519 intermolecular recognition site; other site 216595024520 dimerization interface [polypeptide binding]; other site 216595024523 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 216595024524 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 216595024525 Zn2+ binding site [ion binding]; other site 216595024526 Mg2+ binding site [ion binding]; other site 216595024528 Cache domain; Region: Cache_1; pfam02743 216595024529 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 216595024530 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 216595024531 dimerization interface [polypeptide binding]; other site 216595024532 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 216595024533 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595024534 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595024535 2 probable transmembrane helices predicted for PFLU5316 by TMHMM2.0 at aa 10-32 and 355-377 216595024538 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 216595024539 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 216595024541 10 probable transmembrane helices predicted for PFLU5317 by TMHMM2.0 at aa 5-22, 78-100, 110-127, 134-151, 161-195, 208-230, 263-285, 297-316, 320-342 and 358-380 216595024542 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 216595024544 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595024545 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 216595024546 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 216595024547 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 216595024548 PS00017 ATP/GTP-binding site motif A (P-loop). 216595024549 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595024550 transcription elongation factor regulatory protein; Validated; Region: PRK06342 216595024551 C-term; Region: GreA_GreB; pfam01272 216595024553 glutamate dehydrogenase; Provisional; Region: PRK09414 216595024554 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 216595024555 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 216595024556 NAD(P) binding site [chemical binding]; other site 216595024559 PS00074 Glu / Leu / Phe / Val dehydrogenases active site. 216595024560 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 216595024561 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 216595024562 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595024563 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 216595024564 ABC transporter; Region: ABC_tran_2; pfam12848 216595024565 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 216595024567 PS00017 ATP/GTP-binding site motif A (P-loop). 216595024569 PS00211 ABC transporters family signature. 216595024570 PS00017 ATP/GTP-binding site motif A (P-loop). 216595024571 LysE type translocator; Region: LysE; cl00565 216595024572 6 probable transmembrane helices predicted for PFLU5328 by TMHMM2.0 at aa 5-27, 34-56, 69-86, 107-129, 134-156 and 176-193 216595024573 PAS fold; Region: PAS_3; pfam08447 216595024574 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 216595024575 PAS domain S-box; Region: sensory_box; TIGR00229 216595024576 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 216595024577 PAS domain S-box; Region: sensory_box; TIGR00229 216595024578 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216595024579 putative active site [active] 216595024580 heme pocket [chemical binding]; other site 216595024581 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216595024582 metal binding site [ion binding]; metal-binding site 216595024583 active site 216595024584 I-site; other site 216595024585 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216595024586 2 probable transmembrane helices predicted for PFLU5329 by TMHMM2.0 at aa 28-45 and 258-280 216595024592 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 216595024593 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 216595024594 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 216595024595 dimer interface [polypeptide binding]; other site 216595024596 glycine-pyridoxal phosphate binding site [chemical binding]; other site 216595024597 active site 216595024598 folate binding site [chemical binding]; other site 216595024600 PS00096 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. 216595024601 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 216595024602 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 216595024603 P-loop, Walker A motif; other site 216595024604 Base recognition motif; other site 216595024605 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 216595024608 PS00017 ATP/GTP-binding site motif A (P-loop). 216595024609 Protein of unknown function (DUF466); Region: DUF466; cl01082 216595024611 Carbon starvation protein CstA; Region: CstA; cl00856 216595024613 PilZ domain; Region: PilZ; cl01260 216595024615 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 216595024616 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 216595024618 5 probable transmembrane helices predicted for PFLU5335 by TMHMM2.0 at aa 12-34, 74-96, 101-120, 145-167 and 180-202 216595024619 DNA repair protein RadA; Provisional; Region: PRK11823 216595024620 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 216595024621 Walker A motif/ATP binding site; other site 216595024622 ATP binding site [chemical binding]; other site 216595024623 Walker B motif; other site 216595024624 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 216595024625 PS00017 ATP/GTP-binding site motif A (P-loop). 216595024626 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 216595024627 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 216595024632 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 216595024633 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 216595024634 tetramer interface [polypeptide binding]; other site 216595024635 heme binding pocket [chemical binding]; other site 216595024637 PS00017 ATP/GTP-binding site motif A (P-loop). 216595024638 PS00437 Catalase proximal heme-ligand signature. 216595024639 PS00438 Catalase proximal active site signature. 216595024640 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 216595024642 PS01327 Large-conductance mechanosensitive channels mscL family signature. 216595024643 2 probable transmembrane helices predicted for PFLU5340 by TMHMM2.0 at aa 20-42 and 71-93 216595024644 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 216595024645 ferredoxin-NADP reductase; Provisional; Region: PRK10926 216595024646 FAD binding pocket [chemical binding]; other site 216595024647 FAD binding motif [chemical binding]; other site 216595024648 phosphate binding motif [ion binding]; other site 216595024649 beta-alpha-beta structure motif; other site 216595024650 NAD binding pocket [chemical binding]; other site 216595024653 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 216595024654 Autoinducer binding domain; Region: Autoind_bind; pfam03472 216595024655 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 216595024656 DNA binding residues [nucleotide binding] 216595024657 dimerization interface [polypeptide binding]; other site 216595024660 PS00622 Bacterial regulatory proteins, luxR family signature. 216595024661 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 216595024662 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 216595024663 S-adenosylmethionine binding site [chemical binding]; other site 216595024665 PS00092 N-6 Adenine-specific DNA methylases signature. 216595024666 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 216595024667 1 probable transmembrane helix predicted for PFLU5344 by TMHMM2.0 at aa 21-43 216595024668 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 216595024669 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 216595024671 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 216595024673 enterobactin exporter EntS; Provisional; Region: PRK10489 216595024674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595024675 putative substrate translocation pore; other site 216595024676 8 probable transmembrane helices predicted for PFLU5347 by TMHMM2.0 at aa 15-37, 80-102, 171-193, 221-243, 253-275, 282-304, 309-331 and 369-391 216595024678 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 216595024679 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 216595024680 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 216595024684 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 216595024685 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 216595024688 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 216595024689 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 216595024691 PS00070 Aldehyde dehydrogenases cysteine active site. 216595024693 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 216595024694 Sulfate transporter family; Region: Sulfate_transp; cl00967 216595024696 12 probable transmembrane helices predicted for PFLU5352 by TMHMM2.0 at aa 65-87, 94-116, 141-163, 175-197, 217-236, 241-263, 286-308, 328-350, 360-378, 385-407, 422-444 and 457-475 216595024697 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 216595024698 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 216595024700 PS01230 RNA methyltransferase trmA family signature 1. 216595024701 Protein of unknown function (DUF3532); Region: DUF3532; pfam12050 216595024702 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 216595024703 Outer membrane efflux protein; Region: OEP; pfam02321 216595024704 Outer membrane efflux protein; Region: OEP; pfam02321 216595024707 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 216595024708 PS00543 HlyD family secretion proteins signature. 216595024710 1 probable transmembrane helix predicted for PFLU5357 by TMHMM2.0 at aa 27-46 216595024711 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 216595024712 This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export...; Region: ABCC_Protease_Secretion; cd03246 216595024713 Walker A/P-loop; other site 216595024714 ATP binding site [chemical binding]; other site 216595024715 Q-loop/lid; other site 216595024716 ABC transporter signature motif; other site 216595024717 Walker B; other site 216595024718 D-loop; other site 216595024719 H-loop/switch region; other site 216595024721 PS00211 ABC transporters family signature. 216595024722 PS00017 ATP/GTP-binding site motif A (P-loop). 216595024723 Heme-binding protein A (HasA); Region: HasA; pfam06438 216595024725 Secretin and TonB N terminus short domain; Region: STN; cl06624 216595024726 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 216595024727 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216595024728 N-terminal plug; other site 216595024729 ligand-binding site [chemical binding]; other site 216595024733 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 216595024734 FecR protein; Region: FecR; pfam04773 216595024736 1 probable transmembrane helix predicted for PFLU5362 by TMHMM2.0 at aa 73-90 216595024737 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 216595024738 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216595024739 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 216595024742 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 216595024743 active site 216595024744 trimer interface [polypeptide binding]; other site 216595024745 dimer interface [polypeptide binding]; other site 216595024747 PS01029 Dehydroquinase class II signature. 216595024748 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 216595024749 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 216595024750 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 216595024751 shikimate binding site; other site 216595024752 NAD(P) binding site [chemical binding]; other site 216595024755 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216595024756 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216595024758 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 216595024759 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 216595024760 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 216595024761 dimer interface [polypeptide binding]; other site 216595024762 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 216595024763 active site 216595024764 Fe binding site [ion binding]; other site 216595024767 PS00216 Sugar transport proteins signature 1. 216595024768 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595024769 D-galactonate transporter; Region: 2A0114; TIGR00893 216595024770 putative substrate translocation pore; other site 216595024771 PS00017 ATP/GTP-binding site motif A (P-loop). 216595024772 10 probable transmembrane helices predicted for PFLU5368 by TMHMM2.0 at aa 76-94, 109-131, 144-166, 228-250, 291-313, 333-355, 362-384, 388-410, 423-445 and 455-477 216595024774 EamA-like transporter family; Region: EamA; cl01037 216595024775 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 216595024777 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 216595024779 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 216595024780 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 216595024781 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 216595024782 active site 216595024783 motif I; other site 216595024784 motif II; other site 216595024786 acyl-CoA thioesterase II; Provisional; Region: PRK10526 216595024787 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 216595024788 active site 216595024789 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 216595024790 catalytic triad [active] 216595024791 dimer interface [polypeptide binding]; other site 216595024794 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 216595024795 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 216595024797 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 216595024798 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 216595024800 Predicted flavoproteins [General function prediction only]; Region: COG2081 216595024801 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595024803 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 216595024804 DEAD-like helicases superfamily; Region: DEXDc; smart00487 216595024805 ATP binding site [chemical binding]; other site 216595024806 Mg++ binding site [ion binding]; other site 216595024807 motif III; other site 216595024808 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216595024809 nucleotide binding region [chemical binding]; other site 216595024810 ATP-binding site [chemical binding]; other site 216595024813 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 216595024814 PS00017 ATP/GTP-binding site motif A (P-loop). 216595024815 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 216595024816 EamA-like transporter family; Region: EamA; cl01037 216595024817 EamA-like transporter family; Region: EamA; cl01037 216595024820 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595024822 1 probable transmembrane helix predicted for PFLU5382 by TMHMM2.0 at aa 10-29 216595024823 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595024824 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 216595024825 active site 216595024826 catalytic site [active] 216595024827 substrate binding site [chemical binding]; other site 216595024829 LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167 216595024830 putative metal binding site [ion binding]; other site 216595024832 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; cl01353 216595024834 6 probable transmembrane helices predicted for PFLU5387 by TMHMM2.0 at aa 20-42, 52-74, 95-114, 118-137, 158-180 and 195-217 216595024835 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 216595024836 putative catalytic site [active] 216595024837 putative metal binding site [ion binding]; other site 216595024838 putative phosphate binding site [ion binding]; other site 216595024839 1 probable transmembrane helix predicted for PFLU5388 by TMHMM2.0 at aa 7-28 216595024841 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 216595024842 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216595024843 ATP binding site [chemical binding]; other site 216595024844 putative Mg++ binding site [ion binding]; other site 216595024845 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216595024846 nucleotide binding region [chemical binding]; other site 216595024847 ATP-binding site [chemical binding]; other site 216595024848 Helicase associated domain (HA2); Region: HA2; cl04503 216595024849 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 216595024854 PS00017 ATP/GTP-binding site motif A (P-loop). 216595024855 2 probable transmembrane helices predicted for PFLU5390 by TMHMM2.0 at aa 21-43 and 56-78 216595024856 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 216595024857 Cation efflux family; Region: Cation_efflux; cl00316 216595024858 6 probable transmembrane helices predicted for PFLU5391 by TMHMM2.0 at aa 13-35, 39-61, 82-104, 114-136, 160-177 and 182-199 216595024860 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 216595024861 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595024863 PS00519 Bacterial regulatory proteins, asnC family signature. 216595024865 Protein of unknown function (DUF2788); Region: DUF2788; pfam10981 216595024866 2 probable transmembrane helices predicted for PFLU5394 by TMHMM2.0 at aa 34-56 and 69-91 216595024867 PseudoU_synth_RluE: Pseudouridine synthase, Escherichia coli RluE. This group is comprised of bacterial proteins similar to E. coli RluE. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-...; Region: PseudoU_synth_RluE; cd02566 216595024868 probable active site [active] 216595024870 PS01149 Rsu family of pseudouridine synthase signature. 216595024871 AMP nucleosidase; Provisional; Region: PRK08292 216595024872 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 216595024873 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 216595024875 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 216595024876 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216595024877 active site 216595024879 PS00073 Acyl-CoA dehydrogenases signature 2. 216595024881 PS00072 Acyl-CoA dehydrogenases signature 1. 216595024883 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 216595024884 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 216595024885 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216595024886 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595024887 dimer interface [polypeptide binding]; other site 216595024888 phosphorylation site [posttranslational modification] 216595024889 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595024890 ATP binding site [chemical binding]; other site 216595024891 Mg2+ binding site [ion binding]; other site 216595024892 G-X-G motif; other site 216595024893 Response regulator receiver domain; Region: Response_reg; pfam00072 216595024894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595024895 active site 216595024896 phosphorylation site [posttranslational modification] 216595024897 intermolecular recognition site; other site 216595024898 dimerization interface [polypeptide binding]; other site 216595024904 bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427 216595024905 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 216595024906 dimer interface [polypeptide binding]; other site 216595024907 substrate binding site [chemical binding]; other site 216595024908 ATP binding site [chemical binding]; other site 216595024910 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 216595024911 thiamine phosphate binding site [chemical binding]; other site 216595024912 active site 216595024913 pyrophosphate binding site [ion binding]; other site 216595024915 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 216595024916 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 216595024917 inhibitor-cofactor binding pocket; inhibition site 216595024918 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595024919 catalytic residue [active] 216595024921 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 216595024922 Sel1 repeat; Region: Sel1; cl02723 216595024923 Sel1 repeat; Region: Sel1; cl02723 216595024926 Domain of unknown function (DUF1820); Region: DUF1820; cl11545 216595024928 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 216595024929 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 216595024930 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 216595024931 FeS/SAM binding site; other site 216595024932 TRAM domain; Region: TRAM; cl01282 216595024935 PS01278 Uncharacterized protein family UPF0004 signature. 216595024937 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 216595024938 PhoH-like protein; Region: PhoH; cl12134 216595024940 PS00017 ATP/GTP-binding site motif A (P-loop). 216595024941 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 216595024943 PS01306 Uncharacterized protein family UPF0054 signature. 216595024944 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 216595024945 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 216595024946 Transporter associated domain; Region: CorC_HlyC; cl08393 216595024949 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 216595024950 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 216595024951 putative active site [active] 216595024952 catalytic triad [active] 216595024953 putative dimer interface [polypeptide binding]; other site 216595024954 6 probable transmembrane helices predicted for PFLU5408 by TMHMM2.0 at aa 13-44, 54-76, 83-105, 160-182, 195-214 and 481-500 216595024956 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 216595024957 putative active site [active] 216595024959 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 216595024960 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 216595024961 HIGH motif; other site 216595024962 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 216595024963 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 216595024964 active site 216595024965 KMSKS motif; other site 216595024966 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 216595024967 tRNA binding surface [nucleotide binding]; other site 216595024969 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 216595024972 Lipopolysaccharide-assembly; Region: LptE; cl01125 216595024973 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595024975 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 216595024976 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 216595024978 Domain of unknown function; Region: DUF331; cl01149 216595024980 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 216595024981 lytic murein transglycosylase; Region: MltB_2; TIGR02283 216595024982 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 216595024983 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595024985 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 216595024986 dimer interface [polypeptide binding]; other site 216595024987 catalytic triad [active] 216595024989 lipoyl synthase; Provisional; Region: PRK05481 216595024990 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 216595024992 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 216595024994 PS01313 Lipoate-protein ligase B signature. 216595024995 Protein of unknown function (DUF493); Region: DUF493; cl01102 216595024997 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 216595024998 Beta-lactamase; Region: Beta-lactamase; cl01009 216595024999 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 216595025002 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 216595025003 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 216595025004 Sporulation related domain; Region: SPOR; cl10051 216595025007 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595025008 lytic murein transglycosylase; Region: MltB_2; TIGR02283 216595025009 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 216595025010 N-acetyl-D-glucosamine binding site [chemical binding]; other site 216595025011 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 216595025013 PS00428 Cell cycle proteins ftsW / rodA / spoVE signature. 216595025014 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 216595025015 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 216595025016 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 216595025019 PS00017 ATP/GTP-binding site motif A (P-loop). 216595025020 1 probable transmembrane helix predicted for PFLU5423 by TMHMM2.0 at aa 20-42 216595025021 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 216595025023 Domain of unknown function DUF143; Region: DUF143; cl00519 216595025025 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 216595025026 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 216595025027 active site 216595025028 (T/H)XGH motif; other site 216595025030 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 216595025031 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 216595025032 putative catalytic cysteine [active] 216595025034 PS01223 Gamma-glutamyl phosphate reductase signature. 216595025035 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 216595025036 active site 216595025037 DNA binding site [nucleotide binding] 216595025039 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 216595025040 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 216595025041 active site 216595025042 11 probable transmembrane helices predicted for PFLU5429 by TMHMM2.0 at aa 21-52, 62-81, 145-167, 177-199, 206-228, 263-277, 282-304, 319-341, 348-370, 374-396 and 409-431 216595025045 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 216595025047 LrgB-like family; Region: LrgB; cl00596 216595025049 LrgA family; Region: LrgA; cl00608 216595025051 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 216595025052 putative active site [active] 216595025053 putative catalytic site [active] 216595025055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 216595025056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 216595025057 Peptidase C13 family; Region: Peptidase_C13; cl02159 216595025058 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595025070 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 216595025071 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 216595025072 NAD binding site [chemical binding]; other site 216595025073 active site 216595025075 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 216595025077 aromatic acid decarboxylase; Validated; Region: PRK05920 216595025078 Flavoprotein; Region: Flavoprotein; cl08021 216595025080 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 216595025081 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 216595025082 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 216595025083 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 216595025087 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 216595025088 GAF domain; Region: GAF; cl00853 216595025089 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595025090 Walker A motif; other site 216595025091 ATP binding site [chemical binding]; other site 216595025092 Walker B motif; other site 216595025093 arginine finger; other site 216595025094 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 216595025096 PS00688 Sigma-54 interaction domain C-terminal part signature. 216595025098 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 216595025099 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 216595025101 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 216595025102 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216595025103 NAD(P) binding site [chemical binding]; other site 216595025104 catalytic residues [active] 216595025106 PS00017 ATP/GTP-binding site motif A (P-loop). 216595025107 PS00687 Aldehyde dehydrogenases glutamic acid active site. 216595025108 PS00070 Aldehyde dehydrogenases cysteine active site. 216595025109 ethanolamine permease; Region: 2A0305; TIGR00908 216595025110 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 216595025111 12 probable transmembrane helices predicted for PFLU5442 by TMHMM2.0 at aa 28-50, 60-82, 107-129, 139-161, 166-188, 208-230, 251-273, 300-322, 347-366, 371-393, 406-428 and 433-452 216595025113 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595025114 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 216595025115 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; cl09205 216595025117 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762 216595025119 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 216595025121 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 216595025122 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 216595025123 5 probable transmembrane helices predicted for PFLU5446 by TMHMM2.0 at aa 28-50, 57-79, 129-148, 155-177 and 187-209 216595025125 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 216595025127 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 216595025128 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 216595025129 dimer interface [polypeptide binding]; other site 216595025130 substrate binding site [chemical binding]; other site 216595025131 metal binding sites [ion binding]; metal-binding site 216595025133 PS00387 Inorganic pyrophosphatase signature. 216595025134 Predicted transcriptional regulator [Transcription]; Region: COG2932 216595025135 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216595025136 non-specific DNA binding site [nucleotide binding]; other site 216595025137 salt bridge; other site 216595025138 sequence-specific DNA binding site [nucleotide binding]; other site 216595025139 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 216595025140 Catalytic site [active] 216595025142 Isochorismatase family; Region: Isochorismatase; pfam00857 216595025143 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them...; Region: YcaC_related; cd01012 216595025144 catalytic triad [active] 216595025145 dimer interface [polypeptide binding]; other site 216595025146 conserved cis-peptide bond; other site 216595025148 GAF domain; Region: GAF; cl00853 216595025149 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595025150 dimer interface [polypeptide binding]; other site 216595025151 phosphorylation site [posttranslational modification] 216595025152 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595025153 ATP binding site [chemical binding]; other site 216595025154 Mg2+ binding site [ion binding]; other site 216595025155 G-X-G motif; other site 216595025159 Protein of unknown function (DUF1016); Region: DUF1016; cl01979 216595025161 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 216595025163 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 216595025164 Helix-Turn-Helix DNA binding domain of MerR2-like transcription regulators; Region: HTH_MerR2; cd04769 216595025165 DNA binding residues [nucleotide binding] 216595025166 putative dimer interface [polypeptide binding]; other site 216595025169 Fic family protein [Function unknown]; Region: COG3177 216595025170 Fic/DOC family; Region: Fic; cl00960 216595025171 Fic/DOC family; Region: Fic; cl00960 216595025173 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 216595025175 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 216595025176 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 216595025177 substrate binding pocket [chemical binding]; other site 216595025178 chain length determination region; other site 216595025179 substrate-Mg2+ binding site; other site 216595025180 catalytic residues [active] 216595025181 aspartate-rich region 1; other site 216595025182 active site lid residues [active] 216595025183 aspartate-rich region 2; other site 216595025185 PS00723 Polyprenyl synthetases signature 1. 216595025186 PS00444 Polyprenyl synthetases signature 2. 216595025187 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 216595025188 TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007 216595025189 TPP-binding site; other site 216595025190 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 216595025191 PYR/PP interface [polypeptide binding]; other site 216595025192 dimer interface [polypeptide binding]; other site 216595025193 TPP binding site [chemical binding]; other site 216595025194 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 216595025197 TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779 216595025198 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216595025199 N-terminal plug; other site 216595025200 ligand-binding site [chemical binding]; other site 216595025203 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 216595025204 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal...; Region: BtuF; cd01144 216595025205 cobalamin binding residues [chemical binding]; other site 216595025206 putative BtuC binding residues; other site 216595025207 dimer interface [polypeptide binding]; other site 216595025209 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216595025210 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 216595025211 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 216595025212 dimerization interface [polypeptide binding]; other site 216595025213 active site 216595025215 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cl15306 216595025216 membrane-bound complex binding site; other site 216595025217 hinge residues; other site 216595025218 thiamine monophosphate kinase; Provisional; Region: PRK05731 216595025219 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 216595025220 ATP binding site [chemical binding]; other site 216595025221 dimerization interface [polypeptide binding]; other site 216595025224 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 216595025226 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 216595025227 homopentamer interface [polypeptide binding]; other site 216595025228 active site 216595025230 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 216595025231 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 216595025232 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 216595025233 dimerization interface [polypeptide binding]; other site 216595025234 active site 216595025237 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 216595025238 Lumazine binding domain; Region: Lum_binding; pfam00677 216595025239 Lumazine binding domain; Region: Lum_binding; pfam00677 216595025242 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 216595025243 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 216595025244 catalytic motif [active] 216595025245 Zn binding site [ion binding]; other site 216595025246 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 216595025249 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 216595025250 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 216595025251 ATP cone domain; Region: ATP-cone; pfam03477 216595025253 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 216595025254 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595025255 Predicted methyltransferase [General function prediction only]; Region: COG3897 216595025256 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 216595025258 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 216595025259 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 216595025261 PS00194 Thioredoxin family active site. 216595025262 Protein of unknown function (DUF2796); Region: DUF2796; pfam10986 216595025263 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 216595025264 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 216595025265 Walker A/P-loop; other site 216595025266 ATP binding site [chemical binding]; other site 216595025267 Q-loop/lid; other site 216595025268 ABC transporter signature motif; other site 216595025269 Walker B; other site 216595025270 D-loop; other site 216595025271 H-loop/switch region; other site 216595025273 PS00017 ATP/GTP-binding site motif A (P-loop). 216595025274 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 216595025275 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 216595025276 FtsX-like permease family; Region: FtsX; pfam02687 216595025277 4 probable transmembrane helices predicted for PFLU5481 by TMHMM2.0 at aa 13-35, 293-315, 336-358 and 387-409 216595025279 Protein of unknown function (DUF3299); Region: DUF3299; cl01387 216595025280 Surface antigen; Region: Surface_Ag_2; cl01155 216595025282 PS00695 Enterobacterial virulence outer membrane protein signature 2. 216595025283 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 216595025284 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595025285 NAD(P) binding site [chemical binding]; other site 216595025286 active site 216595025288 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 216595025289 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216595025290 ATP binding site [chemical binding]; other site 216595025291 putative Mg++ binding site [ion binding]; other site 216595025292 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216595025293 nucleotide binding region [chemical binding]; other site 216595025294 ATP-binding site [chemical binding]; other site 216595025295 DEAD/H associated; Region: DEAD_assoc; pfam08494 216595025297 PS00017 ATP/GTP-binding site motif A (P-loop). 216595025298 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216595025300 PS00041 Bacterial regulatory proteins, araC family signature. 216595025302 putative mechanosensitive channel protein; Provisional; Region: PRK11465 216595025303 Mechanosensitive ion channel; Region: MS_channel; pfam00924 216595025306 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 216595025308 cardiolipin synthase 2; Provisional; Region: PRK11263 216595025309 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 216595025310 putative active site [active] 216595025311 catalytic site [active] 216595025312 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 216595025313 putative active site [active] 216595025314 catalytic site [active] 216595025317 Predicted integral membrane protein [Function unknown]; Region: COG0392 216595025318 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 216595025319 8 probable transmembrane helices predicted for PFLU5489 by TMHMM2.0 at aa 15-32, 52-71, 86-108, 128-150, 165-187, 207-229, 239-261 and 282-304 216595025320 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 216595025321 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595025323 PS00708 Prolyl endopeptidase family serine active site. 216595025324 Protein of unknown function (DUF3182); Region: DUF3182; pfam11379 216595025325 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 216595025326 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 216595025327 conserved cys residue [active] 216595025328 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595025330 PS00041 Bacterial regulatory proteins, araC family signature. 216595025332 Isochorismatase family; Region: Isochorismatase; pfam00857 216595025333 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 216595025334 catalytic triad [active] 216595025335 conserved cis-peptide bond; other site 216595025337 trans-aconitate 2-methyltransferase; Provisional; Region: PRK01683 216595025338 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 216595025339 S-adenosylmethionine binding site [chemical binding]; other site 216595025341 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 216595025342 dimer interface [polypeptide binding]; other site 216595025343 ssDNA binding site [nucleotide binding]; other site 216595025344 tetramer (dimer of dimers) interface [polypeptide binding]; other site 216595025346 PS00736 Single-strand binding protein family signature 2. 216595025347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595025348 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216595025349 putative substrate translocation pore; other site 216595025351 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 216595025352 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 216595025353 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 216595025354 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 216595025355 PS00017 ATP/GTP-binding site motif A (P-loop). 216595025356 PS00211 ABC transporters family signature. 216595025358 PS00017 ATP/GTP-binding site motif A (P-loop). 216595025359 PS00211 ABC transporters family signature. 216595025360 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 216595025361 Ferritin-like domain; Region: Ferritin; pfam00210 216595025362 heme binding site [chemical binding]; other site 216595025363 ferroxidase pore; other site 216595025364 ferroxidase diiron center [ion binding]; other site 216595025366 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 216595025367 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 216595025368 tetramer interface [polypeptide binding]; other site 216595025369 heme binding pocket [chemical binding]; other site 216595025370 NADPH binding site [chemical binding]; other site 216595025372 PS00437 Catalase proximal heme-ligand signature. 216595025373 PS00438 Catalase proximal active site signature. 216595025374 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 216595025376 PS01167 Ribosomal protein L17 signature. 216595025377 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 216595025378 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 216595025379 alphaNTD homodimer interface [polypeptide binding]; other site 216595025380 alphaNTD - beta interaction site [polypeptide binding]; other site 216595025381 alphaNTD - beta' interaction site [polypeptide binding]; other site 216595025382 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 216595025386 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 216595025387 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 216595025388 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 216595025389 RNA binding surface [nucleotide binding]; other site 216595025391 PS00632 Ribosomal protein S4 signature. 216595025393 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 216595025395 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 216595025396 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 216595025398 PS00646 Ribosomal protein S13 signature. 216595025399 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 216595025401 PS00828 Ribosomal protein L36 signature. 216595025402 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 216595025403 SecY translocase; Region: SecY; pfam00344 216595025405 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 216595025406 PS00756 Protein secY signature 2. 216595025407 PS00755 Protein secY signature 1. 216595025408 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216595025409 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 216595025412 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658 216595025413 23S rRNA binding site [nucleotide binding]; other site 216595025415 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 216595025416 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 216595025417 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 216595025420 PS00585 Ribosomal protein S5 signature. 216595025421 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 216595025422 5S rRNA interface [nucleotide binding]; other site 216595025423 23S rRNA interface [nucleotide binding]; other site 216595025424 L5 interface [polypeptide binding]; other site 216595025426 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 216595025427 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 216595025428 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 216595025430 PS00525 Ribosomal protein L6 signature 1. 216595025432 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 216595025434 PS00294 Prenyl group binding site (CAAX box). 216595025435 PS00053 Ribosomal protein S8 signature. 216595025436 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 216595025438 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 216595025439 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 216595025440 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 216595025443 PS00358 Ribosomal protein L5 signature. 216595025444 KOW motif; Region: KOW; cl00354 216595025446 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 216595025448 PS00049 Ribosomal protein L14 signature. 216595025449 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 216595025451 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427 216595025452 23S rRNA interface [nucleotide binding]; other site 216595025453 putative translocon interaction site; other site 216595025454 signal recognition particle (SRP54) interaction site; other site 216595025455 L23 interface [polypeptide binding]; other site 216595025456 trigger factor interaction site; other site 216595025458 PS00579 Ribosomal protein L29 signature. 216595025459 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 216595025460 23S rRNA interface [nucleotide binding]; other site 216595025461 5S rRNA interface [nucleotide binding]; other site 216595025462 putative antibiotic binding site [chemical binding]; other site 216595025463 L25 interface [polypeptide binding]; other site 216595025464 L27 interface [polypeptide binding]; other site 216595025466 PS00701 Ribosomal protein L16 signature 2. 216595025467 PS00586 Ribosomal protein L16 signature 1. 216595025468 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 216595025469 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 216595025470 G-X-X-G motif; other site 216595025471 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 216595025473 PS00548 Ribosomal protein S3 signature. 216595025476 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 216595025477 protein-rRNA interface [nucleotide binding]; other site 216595025478 putative translocon binding site; other site 216595025480 PS00464 Ribosomal protein L22 signature. 216595025481 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 216595025483 PS00323 Ribosomal protein S19 signature. 216595025484 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 216595025485 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 216595025486 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 216595025488 PS00467 Ribosomal protein L2 signature. 216595025490 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 216595025492 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 216595025494 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 216595025496 PS00474 Ribosomal protein L3 signature. 216595025497 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 216595025499 PS00361 Ribosomal protein S10 signature. 216595025500 elongation factor Tu; Reviewed; Region: PRK00049 216595025501 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 216595025502 G1 box; other site 216595025503 GEF interaction site [polypeptide binding]; other site 216595025504 GTP/Mg2+ binding site [chemical binding]; other site 216595025505 Switch I region; other site 216595025506 G2 box; other site 216595025507 G3 box; other site 216595025508 Switch II region; other site 216595025509 G4 box; other site 216595025510 G5 box; other site 216595025511 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 216595025512 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 216595025513 Antibiotic Binding Site [chemical binding]; other site 216595025517 PS00301 GTP-binding elongation factors signature. 216595025518 PS00017 ATP/GTP-binding site motif A (P-loop). 216595025519 elongation factor G; Reviewed; Region: PRK00007 216595025520 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 216595025521 G1 box; other site 216595025522 putative GEF interaction site [polypeptide binding]; other site 216595025523 GTP/Mg2+ binding site [chemical binding]; other site 216595025524 Switch I region; other site 216595025525 G2 box; other site 216595025526 G3 box; other site 216595025527 Switch II region; other site 216595025528 G4 box; other site 216595025529 G5 box; other site 216595025530 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 216595025531 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 216595025532 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 216595025537 PS00301 GTP-binding elongation factors signature. 216595025538 PS00017 ATP/GTP-binding site motif A (P-loop). 216595025539 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 216595025541 PS00052 Ribosomal protein S7 signature. 216595025542 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 216595025543 S17 interaction site [polypeptide binding]; other site 216595025544 S8 interaction site; other site 216595025545 16S rRNA interaction site [nucleotide binding]; other site 216595025546 streptomycin interaction site [chemical binding]; other site 216595025547 23S rRNA interaction site [nucleotide binding]; other site 216595025548 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 216595025550 PS00055 Ribosomal protein S12 signature. 216595025551 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 216595025552 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 216595025553 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 216595025554 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 216595025555 DNA-directed RNA polymerase, beta'' subunit; Region: rpoC2_cyan; TIGR02388 216595025556 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 216595025557 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 216595025558 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 216595025559 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 216595025560 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 216595025561 DNA binding site [nucleotide binding] 216595025562 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 216595025568 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 216595025569 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 216595025570 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 216595025571 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591 216595025572 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 216595025573 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 216595025574 RPB11 interaction site [polypeptide binding]; other site 216595025575 RPB12 interaction site [polypeptide binding]; other site 216595025576 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 216595025577 RPB3 interaction site [polypeptide binding]; other site 216595025578 RPB1 interaction site [polypeptide binding]; other site 216595025579 RPB11 interaction site [polypeptide binding]; other site 216595025580 RPB10 interaction site [polypeptide binding]; other site 216595025583 PS01166 RNA polymerases beta chain signature. 216595025584 PS00223 Annexins repeated domain signature. 216595025588 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 216595025589 peripheral dimer interface [polypeptide binding]; other site 216595025590 core dimer interface [polypeptide binding]; other site 216595025591 L10 interface [polypeptide binding]; other site 216595025592 L11 interface [polypeptide binding]; other site 216595025593 putative EF-Tu interaction site [polypeptide binding]; other site 216595025594 putative EF-G interaction site [polypeptide binding]; other site 216595025596 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 216595025597 23S rRNA interface [nucleotide binding]; other site 216595025598 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 216595025600 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 216595025601 mRNA/rRNA interface [nucleotide binding]; other site 216595025603 PS01199 Ribosomal protein L1 signature. 216595025604 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 216595025605 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 216595025606 23S rRNA interface [nucleotide binding]; other site 216595025607 L7/L12 interface [polypeptide binding]; other site 216595025608 putative thiostrepton binding site; other site 216595025609 L25 interface [polypeptide binding]; other site 216595025610 PS00359 Ribosomal protein L11 signature. 216595025613 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 216595025614 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 216595025615 putative homodimer interface [polypeptide binding]; other site 216595025616 KOW motif; Region: KOW; cl00354 216595025617 PS01014 Transcription termination factor nusG signature. 216595025620 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 216595025622 PS01067 Protein secE/sec61-gamma signature. 216595025623 Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130 216595025624 PS00294 Prenyl group binding site (CAAX box). 216595025626 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 216595025627 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595025628 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 216595025631 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 216595025632 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 216595025633 active site 216595025634 HIGH motif; other site 216595025635 dimer interface [polypeptide binding]; other site 216595025636 KMSKS motif; other site 216595025639 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 216595025640 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 216595025641 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 216595025642 Peptidase family M23; Region: Peptidase_M23; pfam01551 216595025644 1 probable transmembrane helix predicted for PFLU5545 by TMHMM2.0 at aa 16-35 216595025647 Uncharacterised protein family (UPF0075); Region: UPF0075; cl04217 216595025649 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 216595025650 PS01152 Hypothetical hesB/yadR/yfhF family signature. 216595025652 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 216595025653 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595025654 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 216595025657 Uncharacterised protein family (UPF0093); Region: UPF0093; cl00863 216595025659 4 probable transmembrane helices predicted for PFLU5549 by TMHMM2.0 at aa 10-29, 50-72, 82-104 and 117-139 216595025660 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 216595025661 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 216595025662 FMN binding site [chemical binding]; other site 216595025663 substrate binding site [chemical binding]; other site 216595025664 putative catalytic residue [active] 216595025665 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595025667 Protein of unknown function (DUF805); Region: DUF805; cl01224 216595025669 4 probable transmembrane helices predicted for PFLU5551 by TMHMM2.0 at aa 139-161, 171-193, 205-227 and 247-269 216595025670 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 216595025671 classical (c) SDRs; Region: SDR_c; cd05233 216595025672 NAD(P) binding site [chemical binding]; other site 216595025673 active site 216595025675 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 216595025676 nucleotide binding site/active site [active] 216595025677 HIT family signature motif; other site 216595025678 catalytic residue [active] 216595025680 PS00892 HIT family signature. 216595025681 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 216595025682 diiron binding motif [ion binding]; other site 216595025683 OsmC-like protein; Region: OsmC; cl00767 216595025685 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 216595025686 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216595025687 ligand binding site [chemical binding]; other site 216595025688 flexible hinge region; other site 216595025689 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 216595025690 putative switch regulator; other site 216595025691 non-specific DNA interactions [nucleotide binding]; other site 216595025692 DNA binding site [nucleotide binding] 216595025693 sequence specific DNA binding site [nucleotide binding]; other site 216595025694 putative cAMP binding site [chemical binding]; other site 216595025696 PS00889 Cyclic nucleotide-binding domain signature 2. 216595025698 PS00042 Bacterial regulatory proteins, crp family signature. 216595025699 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 216595025700 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 216595025701 active site 216595025702 ribulose/triose binding site [chemical binding]; other site 216595025703 phosphate binding site [ion binding]; other site 216595025704 substrate (anthranilate) binding pocket [chemical binding]; other site 216595025705 product (indole) binding pocket [chemical binding]; other site 216595025707 PS00614 Indole-3-glycerol phosphate synthase signature. 216595025708 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 216595025709 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 216595025710 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 216595025712 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595025714 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 216595025715 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 216595025716 glutamine binding [chemical binding]; other site 216595025717 catalytic triad [active] 216595025719 PS00037 Myb DNA-binding domain repeat signature 1. 216595025720 PS00442 Glutamine amidotransferases class-I active site. 216595025721 anthranilate synthase component I; Provisional; Region: PRK13565 216595025722 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 216595025723 chorismate binding enzyme; Region: Chorismate_bind; cl10555 216595025726 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 216595025727 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 216595025728 motif II; other site 216595025730 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 216595025731 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 216595025732 substrate binding site [chemical binding]; other site 216595025733 hexamer interface [polypeptide binding]; other site 216595025734 metal binding site [ion binding]; metal-binding site 216595025736 PS01086 Ribulose-phosphate 3-epimerase family signature 2. 216595025737 PS01085 Ribulose-phosphate 3-epimerase family signature 1. 216595025738 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 216595025739 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 216595025740 active site 216595025741 NAD binding site [chemical binding]; other site 216595025742 metal binding site [ion binding]; metal-binding site 216595025744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595025745 dimer interface [polypeptide binding]; other site 216595025746 conserved gate region; other site 216595025747 putative PBP binding loops; other site 216595025748 ABC-ATPase subunit interface; other site 216595025750 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595025751 PS00430 TonB-dependent receptor proteins signature 1. 216595025752 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595025753 dimer interface [polypeptide binding]; other site 216595025754 conserved gate region; other site 216595025755 putative PBP binding loops; other site 216595025756 ABC-ATPase subunit interface; other site 216595025758 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595025760 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 216595025761 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595025763 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 216595025764 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues...; Region: ABC_PotA_N; cd03300 216595025765 Walker A/P-loop; other site 216595025766 ATP binding site [chemical binding]; other site 216595025767 Q-loop/lid; other site 216595025768 ABC transporter signature motif; other site 216595025769 Walker B; other site 216595025770 D-loop; other site 216595025771 H-loop/switch region; other site 216595025772 TOBE domain; Region: TOBE_2; cl01440 216595025775 PS00211 ABC transporters family signature. 216595025776 PS00017 ATP/GTP-binding site motif A (P-loop). 216595025777 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216595025778 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595025779 active site 216595025780 phosphorylation site [posttranslational modification] 216595025781 intermolecular recognition site; other site 216595025782 dimerization interface [polypeptide binding]; other site 216595025783 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 216595025784 DNA binding residues [nucleotide binding] 216595025785 dimerization interface [polypeptide binding]; other site 216595025787 PS00622 Bacterial regulatory proteins, luxR family signature. 216595025789 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 216595025790 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595025791 substrate binding pocket [chemical binding]; other site 216595025792 membrane-bound complex binding site; other site 216595025793 hinge residues; other site 216595025794 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 216595025795 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216595025796 Histidine kinase; Region: HisKA_3; pfam07730 216595025797 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595025798 ATP binding site [chemical binding]; other site 216595025799 Mg2+ binding site [ion binding]; other site 216595025800 G-X-G motif; other site 216595025804 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 216595025805 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 216595025806 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 216595025807 putative metal binding site [ion binding]; other site 216595025808 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 216595025809 HSP70 interaction site [polypeptide binding]; other site 216595025811 PS00017 ATP/GTP-binding site motif A (P-loop). 216595025812 1 probable transmembrane helix predicted for PFLU5572 by TMHMM2.0 at aa 21-43 216595025813 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 216595025814 Substrate binding site [chemical binding]; other site 216595025815 metal binding site [ion binding]; metal-binding site 216595025817 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 216595025818 Phosphotransferase enzyme family; Region: APH; pfam01636 216595025820 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 216595025821 OstA-like protein; Region: OstA; cl00844 216595025822 Organic solvent tolerance protein; Region: OstA_C; pfam04453 216595025825 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 216595025826 SurA N-terminal domain; Region: SurA_N; pfam09312 216595025827 PPIC-type PPIASE domain; Region: Rotamase; cl08278 216595025828 PPIC-type PPIASE domain; Region: Rotamase; cl08278 216595025832 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 216595025833 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 216595025835 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 216595025837 PS01131 Ribosomal RNA adenine dimethylases signature. 216595025838 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 216595025839 Protein of unknown function (DUF525); Region: DUF525; cl01119 216595025841 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 216595025842 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 216595025843 active site 216595025844 metal binding site [ion binding]; metal-binding site 216595025846 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 216595025847 active site residue [active] 216595025849 PrkA family serine protein kinase; Provisional; Region: PRK15455 216595025850 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595025851 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 216595025853 PS00017 ATP/GTP-binding site motif A (P-loop). 216595025854 PS00107 Protein kinases ATP-binding region signature. 216595025856 Protein of unknown function (DUF444); Region: DUF444; pfam04285 216595025857 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 216595025859 SpoVR family protein; Provisional; Region: PRK11767 216595025860 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 216595025862 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 216595025863 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 216595025864 active site 216595025865 NTP binding site [chemical binding]; other site 216595025866 metal binding triad [ion binding]; metal-binding site 216595025867 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 216595025868 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 216595025871 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 216595025872 catalytic center binding site [active] 216595025873 ATP binding site [chemical binding]; other site 216595025875 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines...; Region: DHNA_DHNTPE; cd00534 216595025876 homooctamer interface [polypeptide binding]; other site 216595025877 active site 216595025879 Domain of unknown function (DUF205); Region: DUF205; cl00410 216595025880 4 probable transmembrane helices predicted for PFLU5588 by TMHMM2.0 at aa 2-24, 80-99, 112-134 and 149-171 216595025882 UGMP family protein; Validated; Region: PRK09604 216595025883 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 216595025885 1 probable transmembrane helix predicted for PFLU5590 by TMHMM2.0 at aa 35-57 216595025886 DNA primase, catalytic core; Region: dnaG; TIGR01391 216595025887 CHC2 zinc finger; Region: zf-CHC2; cl02597 216595025888 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 216595025889 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 216595025890 active site 216595025891 metal binding site [ion binding]; metal-binding site 216595025892 interdomain interaction site; other site 216595025893 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 216595025894 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 216595025899 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 216595025900 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 216595025901 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 216595025902 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 216595025903 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216595025904 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 216595025905 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 216595025906 DNA binding residues [nucleotide binding] 216595025911 PS00715 Sigma-70 factors family signature 1. 216595025914 PS00716 Sigma-70 factors family signature 2. 216595025915 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216595025916 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595025917 substrate binding pocket [chemical binding]; other site 216595025918 membrane-bound complex binding site; other site 216595025919 hinge residues; other site 216595025920 PAS domain S-box; Region: sensory_box; TIGR00229 216595025921 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 216595025922 PAS domain S-box; Region: sensory_box; TIGR00229 216595025923 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216595025924 putative active site [active] 216595025925 heme pocket [chemical binding]; other site 216595025926 PAS domain S-box; Region: sensory_box; TIGR00229 216595025927 PAS domain S-box; Region: sensory_box; TIGR00229 216595025928 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216595025929 putative active site [active] 216595025930 heme pocket [chemical binding]; other site 216595025931 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216595025932 metal binding site [ion binding]; metal-binding site 216595025933 active site 216595025934 I-site; other site 216595025935 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216595025937 1 probable transmembrane helix predicted for PFLU5593 by TMHMM2.0 at aa 338-360 216595025940 PS00017 ATP/GTP-binding site motif A (P-loop). 216595025945 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 216595025946 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595025948 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 216595025950 Predicted amidohydrolase [General function prediction only]; Region: COG0388 216595025951 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 216595025952 putative active site [active] 216595025953 catalytic triad [active] 216595025954 putative dimer interface [polypeptide binding]; other site 216595025956 PS01227 Uncharacterized protein family UPF0012 signature. 216595025957 coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110 216595025958 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 216595025959 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 216595025960 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 216595025961 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 216595025963 PS00143 Insulinase family, zinc-binding region signature. 216595025966 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; cl14189 216595025968 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 216595025969 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 216595025971 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 216595025973 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 216595025974 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 216595025975 FeS/SAM binding site; other site 216595025976 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085 216595025978 PS01305 moaA / nifB / pqqE family signature. 216595025979 Proteolipid membrane potential modulator; Region: Pmp3; cl00431 216595025981 PS01309 Uncharacterized protein family UPF0057 signature. 216595025982 acetylornithine transaminase protein; Provisional; Region: argD; PRK03715 216595025983 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 216595025984 inhibitor-cofactor binding pocket; inhibition site 216595025985 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595025987 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 216595025988 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595025989 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595025990 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 216595025991 dimerization interface [polypeptide binding]; other site 216595025993 PS00044 Bacterial regulatory proteins, lysR family signature. 216595025995 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 216595025996 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 216595025997 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216595025998 active site 216595025999 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 216595026000 PS00216 Sugar transport proteins signature 1. 216595026003 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 216595026004 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 216595026005 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 216595026006 FAD binding site [chemical binding]; other site 216595026007 substrate binding site [chemical binding]; other site 216595026008 catalytic residues [active] 216595026009 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 216595026010 PS00216 Sugar transport proteins signature 1. 216595026013 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216595026014 metal binding site [ion binding]; metal-binding site 216595026015 active site 216595026016 I-site; other site 216595026018 PS00017 ATP/GTP-binding site motif A (P-loop). 216595026019 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 216595026020 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 216595026021 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216595026022 active site 216595026023 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 216595026024 PS00216 Sugar transport proteins signature 1. 216595026027 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 216595026028 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 216595026029 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 216595026031 PS00017 ATP/GTP-binding site motif A (P-loop). 216595026032 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 216595026033 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 216595026034 S-adenosylmethionine binding site [chemical binding]; other site 216595026035 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 216595026037 putative pimeloyl-BioC--CoA transferase BioH; Region: bioH; TIGR01738 216595026039 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 216595026040 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-...; Region: KBL_like; cd06454 216595026041 substrate-cofactor binding pocket; other site 216595026042 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595026043 catalytic residue [active] 216595026045 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 216595026046 biotin synthase; Provisional; Region: PRK15108 216595026047 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 216595026048 FeS/SAM binding site; other site 216595026049 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 216595026052 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 216595026053 DNA utilization protein GntX; Provisional; Region: PRK11595 216595026055 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 216595026056 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595026057 TOBE domain; Region: TOBE_2; cl01440 216595026061 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 216595026062 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 216595026064 possible TAT system recognition site 216595026065 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 216595026066 Phosphotransferase enzyme family; Region: APH; pfam01636 216595026068 Predicted permeases [General function prediction only]; Region: RarD; COG2962 216595026069 9 probable transmembrane helices predicted for PFLU5621 by TMHMM2.0 at aa 10-31, 38-57, 72-94, 103-125, 145-167, 174-196, 211-230, 237-259 and 269-291 216595026071 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 216595026072 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 216595026073 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 216595026076 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 216595026077 active site 216595026079 PS00589 PTS HPR component serine phosphorylation site signature. 216595026080 Response regulator receiver domain; Region: Response_reg; pfam00072 216595026081 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595026082 active site 216595026083 phosphorylation site [posttranslational modification] 216595026084 intermolecular recognition site; other site 216595026085 dimerization interface [polypeptide binding]; other site 216595026087 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 216595026088 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216595026089 ligand binding site [chemical binding]; other site 216595026090 flexible hinge region; other site 216595026091 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain...; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 216595026092 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 216595026093 metal binding triad; other site 216595026094 PS00017 ATP/GTP-binding site motif A (P-loop). 216595026098 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 216595026099 active site 216595026100 substrate binding site [chemical binding]; other site 216595026101 catalytic site [active] 216595026103 RNA polymerase sigma factor; Reviewed; Region: PRK12523 216595026104 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216595026105 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 216595026108 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 216595026109 FecR protein; Region: FecR; pfam04773 216595026110 1 probable transmembrane helix predicted for PFLU5628 by TMHMM2.0 at aa 96-118 216595026112 Secretin and TonB N terminus short domain; Region: STN; cl06624 216595026113 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 216595026114 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216595026115 N-terminal plug; other site 216595026116 ligand-binding site [chemical binding]; other site 216595026120 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 216595026122 4 probable transmembrane helices predicted for PFLU5630 by TMHMM2.0 at aa 21-43, 157-179, 200-222 and 346-368 216595026126 2 probable transmembrane helices predicted for PFLU5631 by TMHMM2.0 at aa 7-29 and 39-56 216595026127 ectoine utilization protein EutC; Validated; Region: PRK08291 216595026128 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595026130 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595026131 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216595026132 substrate binding pocket [chemical binding]; other site 216595026133 membrane-bound complex binding site; other site 216595026134 hinge residues; other site 216595026136 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 216595026137 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216595026138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595026139 dimer interface [polypeptide binding]; other site 216595026140 conserved gate region; other site 216595026141 putative PBP binding loops; other site 216595026142 ABC-ATPase subunit interface; other site 216595026143 3 probable transmembrane helices predicted for PFLU5634 by TMHMM2.0 at aa 15-46, 97-119 and 203-225 216595026145 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595026146 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595026147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595026148 dimer interface [polypeptide binding]; other site 216595026149 conserved gate region; other site 216595026150 putative PBP binding loops; other site 216595026151 ABC-ATPase subunit interface; other site 216595026153 5 probable transmembrane helices predicted for PFLU5635 by TMHMM2.0 at aa 29-51, 64-86, 96-118, 159-181 and 201-220 216595026154 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595026155 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 216595026156 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 216595026157 Walker A/P-loop; other site 216595026158 ATP binding site [chemical binding]; other site 216595026159 Q-loop/lid; other site 216595026160 ABC transporter signature motif; other site 216595026161 Walker B; other site 216595026162 D-loop; other site 216595026163 H-loop/switch region; other site 216595026165 PS00017 ATP/GTP-binding site motif A (P-loop). 216595026166 PS00211 ABC transporters family signature. 216595026167 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 216595026168 YheO-like PAS domain; Region: PAS_6; pfam08348 216595026170 putative glutathione S-transferase; Provisional; Region: PRK10357 216595026171 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 216595026172 putative C-terminal domain interface [polypeptide binding]; other site 216595026173 putative GSH binding site (G-site) [chemical binding]; other site 216595026174 putative dimer interface [polypeptide binding]; other site 216595026175 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 216595026176 dimer interface [polypeptide binding]; other site 216595026177 N-terminal domain interface [polypeptide binding]; other site 216595026178 putative substrate binding pocket (H-site) [chemical binding]; other site 216595026181 Inner membrane protein CreD; Region: CreD; cl01844 216595026183 sensory histidine kinase CreC; Provisional; Region: PRK11100 216595026184 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595026185 dimer interface [polypeptide binding]; other site 216595026186 phosphorylation site [posttranslational modification] 216595026187 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595026188 ATP binding site [chemical binding]; other site 216595026189 Mg2+ binding site [ion binding]; other site 216595026190 G-X-G motif; other site 216595026194 DNA-binding response regulator CreB; Provisional; Region: PRK11083 216595026195 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595026196 active site 216595026197 phosphorylation site [posttranslational modification] 216595026198 intermolecular recognition site; other site 216595026199 dimerization interface [polypeptide binding]; other site 216595026200 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 216595026201 DNA binding site [nucleotide binding] 216595026204 Protein of unknown function (DUF785); Region: DUF785; cl01682 216595026206 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 216595026207 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 216595026208 putative acyl-acceptor binding pocket; other site 216595026209 1 probable transmembrane helix predicted for PFLU5643 by TMHMM2.0 at aa 7-29 216595026211 Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075 216595026212 1 probable transmembrane helix predicted for PFLU5644 by TMHMM2.0 at aa 34-56 216595026213 Anti-sigma-K factor rskA; Region: RskA; cl02208 216595026214 1 probable transmembrane helix predicted for PFLU5645 by TMHMM2.0 at aa 31-50 216595026215 gcgggnnnncccgc 216595026216 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 216595026217 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 216595026218 NAD binding site [chemical binding]; other site 216595026219 catalytic Zn binding site [ion binding]; other site 216595026220 structural Zn binding site [ion binding]; other site 216595026223 PS00059 Zinc-containing alcohol dehydrogenases signature. 216595026224 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 216595026225 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 216595026226 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 216595026227 putative active site [active] 216595026228 putative substrate binding site [chemical binding]; other site 216595026229 putative cosubstrate binding site; other site 216595026230 catalytic site [active] 216595026232 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 216595026234 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 216595026235 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 216595026238 Sarcosine oxidase, delta subunit family; Region: SoxD; cl01767 216595026240 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 216595026241 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 216595026243 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 216595026244 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 216595026245 dimer interface [polypeptide binding]; other site 216595026246 glycine-pyridoxal phosphate binding site [chemical binding]; other site 216595026247 active site 216595026248 folate binding site [chemical binding]; other site 216595026250 PS00096 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. 216595026251 TraX protein; Region: TraX; cl05434 216595026253 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 216595026254 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 216595026255 tetramer interface [polypeptide binding]; other site 216595026256 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595026257 catalytic residue [active] 216595026259 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 216595026261 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 216595026262 Sodium:solute symporter family; Region: SSF; cl00456 216595026264 12 probable transmembrane helices predicted for PFLU5657 by TMHMM2.0 at aa 41-63, 68-90, 111-133, 148-167, 174-196, 206-228, 249-271, 286-308, 335-357, 362-380, 401-423 and 433-455 216595026265 Predicted amidohydrolase [General function prediction only]; Region: COG0388 216595026266 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_2; cd07580 216595026267 putative active site [active] 216595026268 catalytic triad [active] 216595026269 putative dimer interface [polypeptide binding]; other site 216595026271 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 216595026272 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 216595026273 FAD binding pocket [chemical binding]; other site 216595026274 FAD binding motif [chemical binding]; other site 216595026275 phosphate binding motif [ion binding]; other site 216595026276 beta-alpha-beta structure motif; other site 216595026277 NAD binding pocket [chemical binding]; other site 216595026278 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216595026279 catalytic loop [active] 216595026280 iron binding site [ion binding]; other site 216595026282 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 216595026285 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 216595026286 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 216595026287 [2Fe-2S] cluster binding site [ion binding]; other site 216595026288 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 216595026289 putative alpha subunit interface [polypeptide binding]; other site 216595026290 putative active site [active] 216595026291 putative substrate binding site [chemical binding]; other site 216595026292 Fe binding site [ion binding]; other site 216595026294 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 216595026295 Electron transfer flavoprotein, beta subunit [Energy production and conversion]; Region: FixA; COG2086 216595026296 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 216595026297 Ligand Binding Site [chemical binding]; other site 216595026299 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 216595026300 Ligand binding site [chemical binding]; other site 216595026301 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 216595026302 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 216595026305 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 216595026306 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 216595026307 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 216595026309 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216595026311 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216595026312 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 216595026313 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 216595026314 putative active site [active] 216595026315 putative FMN binding site [chemical binding]; other site 216595026316 putative substrate binding site [chemical binding]; other site 216595026317 putative catalytic residue [active] 216595026318 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595026321 Heme NO binding; Region: HNOB; cl15268 216595026322 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics...; Region: rDP_like; cd01301 216595026323 active site 216595026324 dimer interface [polypeptide binding]; other site 216595026326 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 216595026328 HipA N-terminal domain; Region: couple_hipA; TIGR03071 216595026329 HipA-like N-terminal domain; Region: HipA_N; pfam07805 216595026330 HipA-like C-terminal domain; Region: HipA_C; pfam07804 216595026333 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 216595026334 Protein of unknown function (DUF3010); Region: DUF3010; pfam11215 216595026335 Archaeal ATPase; Region: Arch_ATPase; pfam01637 216595026336 PS00017 ATP/GTP-binding site motif A (P-loop). 216595026337 PS00017 ATP/GTP-binding site motif A (P-loop). 216595026338 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 216595026339 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 216595026340 conserved cys residue [active] 216595026341 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595026344 1 probable transmembrane helix predicted for PFLU5672 by TMHMM2.0 at aa 16-33 216595026345 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 216595026346 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 216595026348 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl01276 216595026350 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 216595026351 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 216595026352 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 216595026355 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 216595026356 active site 216595026357 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 216595026358 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 216595026359 conserved cys residue [active] 216595026360 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595026362 PS00041 Bacterial regulatory proteins, araC family signature. 216595026365 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595026366 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 216595026367 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 216595026368 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 216595026371 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 216595026372 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 216595026374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595026375 dimer interface [polypeptide binding]; other site 216595026376 conserved gate region; other site 216595026377 putative PBP binding loops; other site 216595026378 ABC-ATPase subunit interface; other site 216595026379 6 probable transmembrane helices predicted for PFLU5681 by TMHMM2.0 at aa 42-64, 69-88, 95-117, 141-163, 210-232 and 247-266 216595026381 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 216595026382 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595026383 Walker A/P-loop; other site 216595026384 ATP binding site [chemical binding]; other site 216595026385 Q-loop/lid; other site 216595026386 ABC transporter signature motif; other site 216595026387 Walker B; other site 216595026388 D-loop; other site 216595026389 H-loop/switch region; other site 216595026391 PS00017 ATP/GTP-binding site motif A (P-loop). 216595026392 PS00211 ABC transporters family signature. 216595026393 choline transport protein BetT; Provisional; Region: PRK09928 216595026394 BCCT family transporter; Region: BCCT; cl00569 216595026396 PS00017 ATP/GTP-binding site motif A (P-loop). 216595026397 transcriptional regulator BetI; Validated; Region: PRK00767 216595026398 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216595026400 PS01081 Bacterial regulatory proteins, tetR family signature. 216595026401 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216595026402 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 216595026403 tetrameric interface [polypeptide binding]; other site 216595026404 NAD binding site [chemical binding]; other site 216595026405 catalytic residues [active] 216595026407 PS00687 Aldehyde dehydrogenases glutamic acid active site. 216595026408 PS00070 Aldehyde dehydrogenases cysteine active site. 216595026409 choline dehydrogenase; Validated; Region: PRK02106 216595026410 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 216595026412 PS00623 GMC oxidoreductases signature 1. 216595026413 PS00624 GMC oxidoreductases signature 2. 216595026415 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 216595026416 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 216595026418 PS00237 G-protein coupled receptors signature. 216595026419 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 216595026420 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216595026422 putative transporter; Provisional; Region: PRK10504 216595026423 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595026424 putative substrate translocation pore; other site 216595026425 14 probable transmembrane helices predicted for PFLU5690 by TMHMM2.0 at aa 17-39, 54-73, 80-102, 106-128, 135-157, 167-189, 202-219, 229-251, 272-294, 304-326, 333-352, 362-384, 397-419 and 434-456 216595026427 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 216595026428 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 216595026429 ATP binding site [chemical binding]; other site 216595026430 Mg++ binding site [ion binding]; other site 216595026431 motif III; other site 216595026432 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216595026433 nucleotide binding region [chemical binding]; other site 216595026434 ATP-binding site [chemical binding]; other site 216595026435 DbpA RNA binding domain; Region: DbpA; pfam03880 216595026437 PS00017 ATP/GTP-binding site motif A (P-loop). 216595026438 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 216595026441 Predicted flavoproteins [General function prediction only]; Region: COG2081 216595026442 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595026444 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 216595026445 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 216595026447 10 probable transmembrane helices predicted for PFLU5693 by TMHMM2.0 at aa 21-38, 42-59, 66-88, 93-112, 117-134, 149-171, 396-418, 465-484, 491-510 and 520-539 216595026448 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595026449 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216595026450 substrate binding pocket [chemical binding]; other site 216595026451 membrane-bound complex binding site; other site 216595026452 hinge residues; other site 216595026453 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 216595026455 Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; cl11547 216595026456 Protein of unknown function DUF45; Region: DUF45; cl00636 216595026458 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595026459 active site 216595026460 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 216595026461 phosphorylation site [posttranslational modification] 216595026462 intermolecular recognition site; other site 216595026463 dimerization interface [polypeptide binding]; other site 216595026464 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 216595026465 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216595026466 metal binding site [ion binding]; metal-binding site 216595026467 active site 216595026468 I-site; other site 216595026469 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216595026474 1 probable transmembrane helix predicted for PFLU5700 by TMHMM2.0 at aa 13-35 216595026475 hypothetical protein; Provisional; Region: PRK08185 216595026476 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947 216595026477 intersubunit interface [polypeptide binding]; other site 216595026478 active site 216595026479 zinc binding site [ion binding]; other site 216595026480 Na+ binding site [ion binding]; other site 216595026482 PS00806 Fructose-bisphosphate aldolase class-II signature 2. 216595026483 PS00602 Fructose-bisphosphate aldolase class-II signature 1. 216595026484 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604 216595026485 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595026486 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595026487 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198 216595026488 substrate binding site [chemical binding]; other site 216595026489 hinge regions; other site 216595026490 ADP binding site [chemical binding]; other site 216595026491 catalytic site [active] 216595026493 PS00017 ATP/GTP-binding site motif A (P-loop). 216595026494 PS00111 Phosphoglycerate kinase signature. 216595026495 erythrose-4-phosphate dehydrogenase; Region: E4PD_g-proteo; TIGR01532 216595026496 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 216595026497 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 216595026500 gcgggnnnncccgc 216595026501 gcgggnnnncccgc 216595026502 gcgggnnnncccgc 216595026503 gcgggnnnncccgc 216595026504 transketolase; Reviewed; Region: PRK12753 216595026505 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 216595026506 TPP-binding site [chemical binding]; other site 216595026507 dimer interface [polypeptide binding]; other site 216595026508 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 216595026509 PYR/PP interface [polypeptide binding]; other site 216595026510 dimer interface [polypeptide binding]; other site 216595026511 TPP binding site [chemical binding]; other site 216595026512 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 216595026515 PS00802 Transketolase signature 2. 216595026517 PS00801 Transketolase signature 1. 216595026518 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216595026519 putative DNA binding site [nucleotide binding]; other site 216595026520 dimerization interface [polypeptide binding]; other site 216595026521 putative Zn2+ binding site [ion binding]; other site 216595026522 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 216595026523 S-adenosylmethionine binding site [chemical binding]; other site 216595026526 S-adenosylmethionine synthetase; Validated; Region: PRK05250 216595026527 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 216595026528 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 216595026529 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 216595026532 PS00376 S-adenosylmethionine synthetase signature 1. 216595026534 PS00377 S-adenosylmethionine synthetase signature 2. 216595026535 1 probable transmembrane helix predicted for PFLU5710 by TMHMM2.0 at aa 21-43 216595026536 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 216595026537 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 216595026538 nucleotide binding pocket [chemical binding]; other site 216595026539 K-X-D-G motif; other site 216595026540 catalytic site [active] 216595026541 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 216595026542 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595026545 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 216595026547 Cytochrome C'; Region: Cytochrom_C_2; cl01610 216595026549 PS00190 Cytochrome c family heme-binding site signature. 216595026550 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595026551 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 216595026552 MltA specific insert domain; Region: MltA; cl08398 216595026553 3D domain; Region: 3D; cl01439 216595026554 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595026555 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 216595026558 MAPEG family; Region: MAPEG; cl09190 216595026559 PS00430 TonB-dependent receptor proteins signature 1. 216595026560 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 216595026561 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 216595026563 12 probable transmembrane helices predicted for PFLU5716 by TMHMM2.0 at aa 20-42, 69-86, 98-120, 130-152, 165-187, 202-224, 231-248, 252-274, 295-314, 319-341, 354-376 and 381-400 216595026564 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 216595026565 PS00017 ATP/GTP-binding site motif A (P-loop). 216595026566 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 216595026567 active site 216595026568 nucleophile elbow; other site 216595026570 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain...; Region: BFIT_BACH; cd03442 216595026572 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 216595026573 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595026574 oligomerization interface [polypeptide binding]; other site 216595026575 active site 216595026576 NAD+ binding site [chemical binding]; other site 216595026578 PS00738 S-adenosyl-L-homocysteine hydrolase signature 1. 216595026580 PS00739 S-adenosyl-L-homocysteine hydrolase signature 2. 216595026581 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 216595026582 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537 216595026583 FAD binding site [chemical binding]; other site 216595026585 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216595026586 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595026587 substrate binding pocket [chemical binding]; other site 216595026588 membrane-bound complex binding site; other site 216595026589 hinge residues; other site 216595026590 helicase 45; Provisional; Region: PTZ00424 216595026591 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 216595026592 ATP binding site [chemical binding]; other site 216595026593 Mg++ binding site [ion binding]; other site 216595026594 motif III; other site 216595026595 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216595026596 nucleotide binding region [chemical binding]; other site 216595026597 ATP-binding site [chemical binding]; other site 216595026599 PS00017 ATP/GTP-binding site motif A (P-loop). 216595026600 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 216595026602 YceI-like domain; Region: YceI; cl01001 216595026604 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 216595026606 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK07030 216595026607 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 216595026608 inhibitor-cofactor binding pocket; inhibition site 216595026609 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595026610 catalytic residue [active] 216595026612 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 216595026613 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 216595026615 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 216595026616 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595026617 substrate binding pocket [chemical binding]; other site 216595026618 membrane-bound complex binding site; other site 216595026619 hinge residues; other site 216595026621 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 216595026622 homotrimer interaction site [polypeptide binding]; other site 216595026623 putative active site [active] 216595026625 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409 216595026626 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 216595026628 1 probable transmembrane helix predicted for PFLU5731 by TMHMM2.0 at aa 7-26 216595026629 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 216595026630 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595026631 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595026632 dimerization interface [polypeptide binding]; other site 216595026635 Haemolysin-III related; Region: HlyIII; cl03831 216595026637 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216595026638 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595026639 The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416 216595026640 putative dimerization interface [polypeptide binding]; other site 216595026642 PS00044 Bacterial regulatory proteins, lysR family signature. 216595026644 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 216595026646 Malonate transporter MadL subunit; Region: MadL; cl04273 216595026648 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595026649 Acyl transferase domain; Region: Acyl_transf_1; cl08282 216595026650 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 216595026652 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; cl07913 216595026653 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 216595026655 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 216595026656 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 216595026658 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 216595026660 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 216595026661 PS00017 ATP/GTP-binding site motif A (P-loop). 216595026662 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 216595026664 pilus (type IV secretion system) biosynthesis gene cluster 216595026665 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 216595026666 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 216595026667 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 216595026668 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 216595026669 putative binding surface; other site 216595026670 active site 216595026671 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 216595026672 putative binding surface; other site 216595026673 active site 216595026674 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 216595026675 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595026676 ATP binding site [chemical binding]; other site 216595026677 Mg2+ binding site [ion binding]; other site 216595026678 G-X-G motif; other site 216595026679 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 216595026680 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595026681 active site 216595026682 phosphorylation site [posttranslational modification] 216595026683 intermolecular recognition site; other site 216595026684 dimerization interface [polypeptide binding]; other site 216595026694 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216595026695 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595026697 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 216595026699 Response regulator receiver domain; Region: Response_reg; pfam00072 216595026700 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595026701 active site 216595026702 phosphorylation site [posttranslational modification] 216595026703 intermolecular recognition site; other site 216595026704 dimerization interface [polypeptide binding]; other site 216595026706 Response regulator receiver domain; Region: Response_reg; pfam00072 216595026707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595026708 active site 216595026709 phosphorylation site [posttranslational modification] 216595026710 intermolecular recognition site; other site 216595026711 dimerization interface [polypeptide binding]; other site 216595026713 glutathione synthetase; Provisional; Region: PRK05246 216595026714 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 216595026715 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 216595026718 Gram-negative bacterial tonB protein; Region: TonB; cl10048 216595026719 1 probable transmembrane helix predicted for PFLU5754 by TMHMM2.0 at aa 22-44 216595026720 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 216595026722 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 216595026724 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 216595026726 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 216595026727 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 216595026728 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595026730 PS00097 Aspartate and ornithine carbamoyltransferases signature. 216595026732 dihydroorotase; Validated; Region: pyrC; PRK09357 216595026733 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C...; Region: DHOase_IIa; cd01317 216595026734 active site 216595026736 TM2 domain; Region: TM2; cl00984 216595026739 NlpC/P60 family; Region: NLPC_P60; cl11438 216595026741 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 216595026742 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 216595026743 Walker A motif; other site 216595026744 ATP binding site [chemical binding]; other site 216595026745 Walker B motif; other site 216595026747 PS00662 Bacterial type II secretion system protein E signature. 216595026748 PS00017 ATP/GTP-binding site motif A (P-loop). 216595026749 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 216595026750 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 216595026751 catalytic residue [active] 216595026753 PS01211 Uncharacterized protein family UPF0001 signature. 216595026754 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 216595026755 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595026757 PS00521 Delta 1-pyrroline-5-carboxylate reductase signature. 216595026758 YGGT family; Region: YGGT; cl00508 216595026759 YGGT family; Region: YGGT; cl00508 216595026760 4 probable transmembrane helices predicted for PFLU5765 by TMHMM2.0 at aa 7-29, 69-91, 98-120 and 162-184 216595026763 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 216595026764 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595026766 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 216595026767 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 216595026768 S-adenosylmethionine binding site [chemical binding]; other site 216595026770 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515 216595026771 active site 216595026772 dimerization interface [polypeptide binding]; other site 216595026774 HemN family oxidoreductase; Provisional; Region: PRK05660 216595026775 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 216595026776 FeS/SAM binding site; other site 216595026777 HemN C-terminal region; Region: HemN_C; pfam06969 216595026780 Protein of unknown function (DUF3392); Region: DUF3392; pfam11872 216595026781 3 probable transmembrane helices predicted for PFLU5771 by TMHMM2.0 at aa 20-42, 55-77 and 87-104 216595026782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 216595026784 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 216595026785 ThiS interaction site; other site 216595026786 putative active site [active] 216595026787 tetramer interface [polypeptide binding]; other site 216595026789 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 216595026790 thiS-thiF/thiG interaction site; other site 216595026792 Protein of unknown function (DUF423); Region: DUF423; cl01008 216595026794 Transglycosylase; Region: Transgly; cl07896 216595026795 1 probable transmembrane helix predicted for PFLU5776 by TMHMM2.0 at aa 9-31 216595026797 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 216595026798 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216595026799 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 216595026801 PS00716 Sigma-70 factors family signature 2. 216595026803 PS00715 Sigma-70 factors family signature 1. 216595026804 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 216595026805 FtsX-like permease family; Region: FtsX; pfam02687 216595026807 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 216595026808 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595026809 Walker A/P-loop; other site 216595026810 ATP binding site [chemical binding]; other site 216595026811 Q-loop/lid; other site 216595026812 ABC transporter signature motif; other site 216595026813 Walker B; other site 216595026814 D-loop; other site 216595026815 H-loop/switch region; other site 216595026817 PS00017 ATP/GTP-binding site motif A (P-loop). 216595026818 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 216595026819 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 216595026820 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 216595026821 P loop; other site 216595026822 GTP binding site [chemical binding]; other site 216595026824 PS00300 SRP54-type proteins GTP-binding domain signature. 216595026825 PS00017 ATP/GTP-binding site motif A (P-loop). 216595026827 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 216595026828 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 216595026829 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 216595026832 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 216595026833 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 216595026834 1 probable transmembrane helix predicted for PFLU5783 by TMHMM2.0 at aa 9-28 216595026837 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 216595026838 S-adenosylmethionine binding site [chemical binding]; other site 216595026840 PS00092 N-6 Adenine-specific DNA methylases signature. 216595026841 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 216595026843 PS01133 Uncharacterized protein family UPF0017 signature. 216595026844 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 216595026845 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but...; Region: TST_Repeat_1; cd01448 216595026846 active site residue [active] 216595026847 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 216595026848 active site residue [active] 216595026850 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595026851 PS00215 Mitochondrial energy transfer proteins signature. 216595026853 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216595026854 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216595026856 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 216595026857 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 216595026858 NAD(P) binding site [chemical binding]; other site 216595026859 catalytic residues [active] 216595026861 PS00211 ABC transporters family signature. 216595026862 PS00687 Aldehyde dehydrogenases glutamic acid active site. 216595026863 PS00070 Aldehyde dehydrogenases cysteine active site. 216595026864 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 216595026865 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 216595026866 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 216595026870 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 216595026871 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 216595026872 active site 216595026873 (T/H)XGH motif; other site 216595026875 ferredoxin; Validated; Region: PRK07118 216595026877 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 216595026878 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 216595026879 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 216595026880 DNA binding site [nucleotide binding] 216595026881 catalytic residue [active] 216595026882 H2TH interface [polypeptide binding]; other site 216595026883 putative catalytic residues [active] 216595026884 turnover-facilitating residue; other site 216595026885 intercalation triad [nucleotide binding]; other site 216595026886 8OG recognition residue [nucleotide binding]; other site 216595026887 putative reading head residues; other site 216595026888 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 216595026889 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 216595026892 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 216595026893 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 216595026895 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 216595026896 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 216595026897 S-adenosylmethionine binding site [chemical binding]; other site 216595026899 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 216595026900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595026901 putative substrate translocation pore; other site 216595026902 11 probable transmembrane helices predicted for PFLU5796 by TMHMM2.0 at aa 12-34, 49-71, 78-100, 105-124, 136-158, 168-190, 211-233, 248-270, 282-304, 338-360 and 367-389 216595026904 PS00216 Sugar transport proteins signature 1. 216595026905 Dehydratase family; Region: ILVD_EDD; cl00340 216595026906 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 216595026908 PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1. 216595026909 PS00017 ATP/GTP-binding site motif A (P-loop). 216595026910 PS00887 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 2. 216595026911 Secretin and TonB N terminus short domain; Region: STN; cl06624 216595026912 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 216595026913 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216595026914 N-terminal plug; other site 216595026915 ligand-binding site [chemical binding]; other site 216595026919 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595026920 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 216595026921 FecR protein; Region: FecR; pfam04773 216595026923 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 216595026924 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216595026925 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 216595026926 DNA binding residues [nucleotide binding] 216595026929 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 216595026930 10 probable transmembrane helices predicted for PFLU5802 by TMHMM2.0 at aa 5-20, 33-51, 71-93, 105-127, 186-205, 232-254, 264-286, 333-355, 370-392 and 399-421 216595026932 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209 216595026933 folate binding site [chemical binding]; other site 216595026934 NADP+ binding site [chemical binding]; other site 216595026936 PS00075 Dihydrofolate reductase signature. 216595026937 Protein of unknown function (DUF2868); Region: DUF2868; pfam11067 216595026938 5 probable transmembrane helices predicted for PFLU5804 by TMHMM2.0 at aa 72-94, 104-126, 174-196, 211-233 and 254-276 216595026939 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 216595026940 G1 box; other site 216595026941 GTP/Mg2+ binding site [chemical binding]; other site 216595026942 Switch I region; other site 216595026943 G2 box; other site 216595026944 Switch II region; other site 216595026945 G3 box; other site 216595026946 G4 box; other site 216595026947 Domain of unknown function (DUF3482); Region: DUF3482; pfam11981 216595026949 PS00017 ATP/GTP-binding site motif A (P-loop). 216595026950 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 216595026952 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 216595026954 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 216595026955 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595026957 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 216595026958 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595026959 dimer interface [polypeptide binding]; other site 216595026960 conserved gate region; other site 216595026961 putative PBP binding loops; other site 216595026962 ABC-ATPase subunit interface; other site 216595026963 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595026964 dimer interface [polypeptide binding]; other site 216595026965 conserved gate region; other site 216595026966 putative PBP binding loops; other site 216595026967 ABC-ATPase subunit interface; other site 216595026970 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 216595026971 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595026972 Walker A/P-loop; other site 216595026973 ATP binding site [chemical binding]; other site 216595026974 Q-loop/lid; other site 216595026975 ABC transporter signature motif; other site 216595026976 Walker B; other site 216595026977 D-loop; other site 216595026978 H-loop/switch region; other site 216595026979 TOBE domain; Region: TOBE_2; cl01440 216595026982 PS00211 ABC transporters family signature. 216595026983 PS00017 ATP/GTP-binding site motif A (P-loop). 216595026984 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 216595026985 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595026986 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 216595026987 dimerization interface [polypeptide binding]; other site 216595026990 PS00044 Bacterial regulatory proteins, lysR family signature. 216595026991 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 216595026992 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 216595026993 metal-binding site [ion binding] 216595026994 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216595026995 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 216595026997 PS01229 Hypothetical cof family signature 2. 216595026998 PS00017 ATP/GTP-binding site motif A (P-loop). 216595026999 PS00154 E1-E2 ATPases phosphorylation site. 216595027001 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 216595027002 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 216595027003 DNA binding residues [nucleotide binding] 216595027004 dimer interface [polypeptide binding]; other site 216595027005 putative metal binding site [ion binding]; other site 216595027008 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 216595027009 dimerization interface [polypeptide binding]; other site 216595027010 active site 216595027012 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 216595027014 PS01311 Prolipoprotein diacylglyceryl transferase signature. 216595027015 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 216595027017 Protein of unknown function (DUF833); Region: DUF833; cl01315 216595027019 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 216595027020 GAF domain; Region: GAF; cl00853 216595027021 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 216595027022 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 216595027023 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 216595027025 PS00742 PEP-utilizing enzymes signature 2. 216595027029 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where...; Region: Ap4A_hydrolase_plant_like; cd03671 216595027030 putative active site [active] 216595027031 Ap4A binding site [chemical binding]; other site 216595027032 nudix motif; other site 216595027033 putative metal binding site [ion binding]; other site 216595027035 PS00893 mutT domain signature. 216595027036 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 216595027037 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 216595027038 motif II; other site 216595027040 Predicted integral membrane protein (DUF2269); Region: DUF2269; cl02335 216595027041 threonine dehydratase; Reviewed; Region: PRK09224 216595027042 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 216595027043 tetramer interface [polypeptide binding]; other site 216595027044 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595027045 catalytic residue [active] 216595027046 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 216595027047 putative Ile/Val binding site [chemical binding]; other site 216595027048 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 216595027049 putative Ile/Val binding site [chemical binding]; other site 216595027053 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 216595027054 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 216595027055 tetramer (dimer of dimers) interface [polypeptide binding]; other site 216595027056 active site 216595027057 dimer interface [polypeptide binding]; other site 216595027059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 216595027060 SdiA-regulated; Region: SdiA-regulated; cd09971 216595027061 putative active site [active] 216595027063 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 216595027064 SdiA-regulated; Region: SdiA-regulated; cd09971 216595027065 putative active site [active] 216595027067 1 probable transmembrane helix predicted for PFLU5826 by TMHMM2.0 at aa 21-40 216595027068 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 216595027070 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 216595027071 FAD binding domain; Region: FAD_binding_4; pfam01565 216595027074 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 216595027075 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595027076 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 216595027077 L-serine binding site [chemical binding]; other site 216595027078 ACT domain interface; other site 216595027081 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 216595027082 PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. 216595027084 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595027085 substrate binding pocket [chemical binding]; other site 216595027086 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216595027088 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 216595027089 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 216595027090 Integrase core domain; Region: rve; cl01316 216595027092 Protein of unknown function (DUF523); Region: DUF523; cl00733 216595027094 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 216595027096 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 216595027097 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595027099 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 216595027100 1 probable transmembrane helix predicted for PFLU5837 by TMHMM2.0 at aa 7-29 216595027101 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595027102 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 216595027103 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 216595027104 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and 7-...; Region: Ntn_PGA_like; cd03747 216595027105 active site 216595027106 1 probable transmembrane helix predicted for PFLU5838 by TMHMM2.0 at aa 7-24 216595027108 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 216595027109 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 216595027110 conserved cys residue [active] 216595027111 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216595027115 PS00017 ATP/GTP-binding site motif A (P-loop). 216595027116 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 216595027118 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 216595027119 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595027120 dimer interface [polypeptide binding]; other site 216595027121 conserved gate region; other site 216595027122 putative PBP binding loops; other site 216595027123 ABC-ATPase subunit interface; other site 216595027125 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595027126 PS00340 Growth factor and cytokines receptors family signature 2. 216595027127 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595027128 dimer interface [polypeptide binding]; other site 216595027129 conserved gate region; other site 216595027130 putative PBP binding loops; other site 216595027131 ABC-ATPase subunit interface; other site 216595027133 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595027134 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 216595027135 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595027136 Walker A/P-loop; other site 216595027137 ATP binding site [chemical binding]; other site 216595027138 Q-loop/lid; other site 216595027139 ABC transporter signature motif; other site 216595027140 Walker B; other site 216595027141 D-loop; other site 216595027142 H-loop/switch region; other site 216595027143 TOBE domain; Region: TOBE_2; cl01440 216595027146 PS00211 ABC transporters family signature. 216595027147 PS00017 ATP/GTP-binding site motif A (P-loop). 216595027148 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 216595027149 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595027151 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595027152 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 216595027154 PS00017 ATP/GTP-binding site motif A (P-loop). 216595027155 PS00017 ATP/GTP-binding site motif A (P-loop). 216595027156 putative aminotransferase; Validated; Region: PRK07480 216595027157 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 216595027158 inhibitor-cofactor binding pocket; inhibition site 216595027159 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595027160 catalytic residue [active] 216595027162 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 216595027163 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 216595027165 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 216595027166 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 216595027168 PS00181 Glutamine synthetase putative ATP-binding region signature. 216595027170 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 216595027172 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216595027173 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216595027175 TOBE domain; Region: TOBE_2; cl01440 216595027177 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 216595027178 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595027179 Walker A/P-loop; other site 216595027180 ATP binding site [chemical binding]; other site 216595027181 Q-loop/lid; other site 216595027182 ABC transporter signature motif; other site 216595027183 Walker B; other site 216595027184 D-loop; other site 216595027185 H-loop/switch region; other site 216595027187 PS00211 ABC transporters family signature. 216595027188 PS00017 ATP/GTP-binding site motif A (P-loop). 216595027189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595027190 dimer interface [polypeptide binding]; other site 216595027191 conserved gate region; other site 216595027192 putative PBP binding loops; other site 216595027193 ABC-ATPase subunit interface; other site 216595027195 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 216595027196 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 216595027197 active site 216595027198 dimer interface [polypeptide binding]; other site 216595027199 non-prolyl cis peptide bond; other site 216595027200 insertion regions; other site 216595027202 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 216595027203 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595027204 substrate binding pocket [chemical binding]; other site 216595027205 membrane-bound complex binding site; other site 216595027206 hinge residues; other site 216595027208 1 probable transmembrane helix predicted for PFLU5857 by TMHMM2.0 at aa 7-29 216595027209 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 216595027211 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 216595027212 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 216595027213 dimer interface [polypeptide binding]; other site 216595027214 decamer (pentamer of dimers) interface [polypeptide binding]; other site 216595027215 catalytic triad [active] 216595027217 outer membrane porin, OprD family; Region: OprD; pfam03573 216595027219 N-acetylglutamate synthase; Validated; Region: PRK05279 216595027220 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an N-...; Region: AAK_NAGS-ABP; cd04237 216595027221 putative feedback inhibition sensing region; other site 216595027222 putative nucleotide binding site [chemical binding]; other site 216595027223 putative substrate binding site [chemical binding]; other site 216595027224 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 216595027227 acetylornithine deacetylase; Provisional; Region: PRK05111 216595027228 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 216595027229 metal binding site [ion binding]; metal-binding site 216595027230 putative dimer interface [polypeptide binding]; other site 216595027233 Uncharacterized conserved protein [Function unknown]; Region: COG3025 216595027234 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 216595027235 putative active site [active] 216595027236 putative metal binding residues [ion binding]; other site 216595027237 signature motif; other site 216595027238 putative triphosphate binding site [ion binding]; other site 216595027240 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 216595027241 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595027243 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 216595027244 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 216595027245 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 216595027246 Walker A motif; other site 216595027247 ATP binding site [chemical binding]; other site 216595027248 Walker B motif; other site 216595027251 PS00017 ATP/GTP-binding site motif A (P-loop). 216595027252 PS00662 Bacterial type II secretion system protein E signature. 216595027253 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 216595027254 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 216595027255 1 probable transmembrane helix predicted for PFLU5868 by TMHMM2.0 at aa 7-29 216595027257 PS00216 Sugar transport proteins signature 1. 216595027258 PS01270 Band 7 protein family signature. 216595027259 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 216595027261 2 probable transmembrane helices predicted for PFLU5869 by TMHMM2.0 at aa 13-35 and 55-73 216595027262 Protein of unknown function (DUF2388); Region: DUF2388; cl09731 216595027263 Surface antigen; Region: Surface_Ag_2; cl01155 216595027264 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 216595027265 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 216595027266 inhibitor-cofactor binding pocket; inhibition site 216595027267 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595027268 catalytic residue [active] 216595027270 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 216595027271 lipoyl attachment site [posttranslational modification]; other site 216595027273 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 216595027274 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 216595027276 PS00213 Lipocalin signature. 216595027278 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 216595027279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595027280 dimer interface [polypeptide binding]; other site 216595027281 conserved gate region; other site 216595027282 putative PBP binding loops; other site 216595027283 ABC-ATPase subunit interface; other site 216595027285 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595027287 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 216595027288 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 216595027289 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595027291 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK05714 216595027292 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595027293 PS01304 ubiH/COQ6 monooxygenase family signature. 216595027295 1 probable transmembrane helix predicted for PFLU5877 by TMHMM2.0 at aa 7-29 216595027296 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 216595027297 CoenzymeA binding site [chemical binding]; other site 216595027298 subunit interaction site [polypeptide binding]; other site 216595027299 PHB binding site; other site 216595027300 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595027301 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 216595027303 1 probable transmembrane helix predicted for PFLU5879 by TMHMM2.0 at aa 7-26 216595027304 proline aminopeptidase P II; Provisional; Region: PRK10879 216595027305 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 216595027306 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action...; Region: Prolidase; cd01087 216595027307 active site 216595027309 PS00213 Lipocalin signature. 216595027311 Uncharacterised protein family (UPF0149); Region: UPF0149; cl01173 216595027313 TIGR02449 family protein; Region: TIGR02449 216595027314 Cell division protein ZapA; Region: ZapA; cl01146 216595027316 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 216595027318 1 probable transmembrane helix predicted for PFLU5886 by TMHMM2.0 at aa 17-39 216595027319 EVE domain; Region: EVE; cl00728 216595027321 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 216595027322 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404 216595027323 1 probable transmembrane helix predicted for PFLU5888 by TMHMM2.0 at aa 12-34 216595027325 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595027326 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 216595027327 Walker A/P-loop; other site 216595027328 ATP binding site [chemical binding]; other site 216595027329 Q-loop/lid; other site 216595027330 ABC transporter signature motif; other site 216595027331 Walker B; other site 216595027332 D-loop; other site 216595027333 H-loop/switch region; other site 216595027334 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595027335 Walker A/P-loop; other site 216595027336 ATP binding site [chemical binding]; other site 216595027337 Q-loop/lid; other site 216595027338 ABC transporter signature motif; other site 216595027339 Walker B; other site 216595027340 D-loop; other site 216595027341 H-loop/switch region; other site 216595027342 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 216595027343 ABC-2 type transporter; Region: ABC2_membrane; cl11417 216595027345 PS00017 ATP/GTP-binding site motif A (P-loop). 216595027346 PS00211 ABC transporters family signature. 216595027348 PS00017 ATP/GTP-binding site motif A (P-loop). 216595027349 7 probable transmembrane helices predicted for PFLU5889 by TMHMM2.0 at aa 553-575, 705-727, 760-782, 789-811, 816-838, 845-867 and 877-899 216595027351 ABC-2 type transporter; Region: ABC2_membrane; cl11417 216595027352 6 probable transmembrane helices predicted for PFLU5890 by TMHMM2.0 at aa 23-45, 177-199, 231-253, 258-280, 287-306 and 341-363 216595027354 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 216595027356 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 216595027357 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 216595027358 NAD(P) binding site [chemical binding]; other site 216595027362 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 216595027363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595027364 putative substrate translocation pore; other site 216595027365 12 probable transmembrane helices predicted for PFLU5893 by TMHMM2.0 at aa 28-45, 65-87, 94-116, 120-142, 155-177, 187-206, 254-273, 293-312, 319-341, 351-373, 380-402 and 417-439 216595027367 PS00942 glpT family of transporters signature. 216595027368 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 216595027369 putative active site pocket [active] 216595027370 dimerization interface [polypeptide binding]; other site 216595027371 putative catalytic residue [active] 216595027373 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 216595027374 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216595027375 N-terminal plug; other site 216595027376 ligand-binding site [chemical binding]; other site 216595027379 PS00430 TonB-dependent receptor proteins signature 1. 216595027380 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 216595027381 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216595027382 catalytic loop [active] 216595027383 iron binding site [ion binding]; other site 216595027384 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD...; Region: flavin_oxioreductase; cd06189 216595027385 FAD binding pocket [chemical binding]; other site 216595027386 FAD binding motif [chemical binding]; other site 216595027387 phosphate binding motif [ion binding]; other site 216595027388 beta-alpha-beta structure motif; other site 216595027389 NAD binding pocket [chemical binding]; other site 216595027393 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 216595027395 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 216595027397 transcription termination factor Rho; Provisional; Region: rho; PRK09376 216595027398 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 216595027399 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent...; Region: Rho_CSD; cd04459 216595027400 RNA binding site [nucleotide binding]; other site 216595027401 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128 216595027402 multimer interface [polypeptide binding]; other site 216595027403 Walker A motif; other site 216595027404 ATP binding site [chemical binding]; other site 216595027405 Walker B motif; other site 216595027407 PS00017 ATP/GTP-binding site motif A (P-loop). 216595027410 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 216595027411 catalytic residues [active] 216595027413 PS00194 Thioredoxin family active site. 216595027414 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216595027415 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595027416 DNA-binding site [nucleotide binding]; DNA binding site 216595027417 FCD domain; Region: FCD; cl11656 216595027419 PS00211 ABC transporters family signature. 216595027421 PS00043 Bacterial regulatory proteins, gntR family signature. 216595027422 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216595027423 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 216595027424 substrate binding pocket [chemical binding]; other site 216595027425 membrane-bound complex binding site; other site 216595027426 hinge residues; other site 216595027428 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216595027429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595027430 dimer interface [polypeptide binding]; other site 216595027431 conserved gate region; other site 216595027432 putative PBP binding loops; other site 216595027433 ABC-ATPase subunit interface; other site 216595027435 5 probable transmembrane helices predicted for PFLU5904 by TMHMM2.0 at aa 20-42, 55-77, 87-104, 138-160 and 191-213 216595027436 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216595027437 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595027438 dimer interface [polypeptide binding]; other site 216595027439 conserved gate region; other site 216595027440 putative PBP binding loops; other site 216595027441 ABC-ATPase subunit interface; other site 216595027443 5 probable transmembrane helices predicted for PFLU5905 by TMHMM2.0 at aa 15-37, 57-79, 83-105, 142-164 and 184-203 216595027444 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 216595027445 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 216595027446 Walker A/P-loop; other site 216595027447 ATP binding site [chemical binding]; other site 216595027448 Q-loop/lid; other site 216595027449 ABC transporter signature motif; other site 216595027450 Walker B; other site 216595027451 D-loop; other site 216595027452 H-loop/switch region; other site 216595027454 PS00017 ATP/GTP-binding site motif A (P-loop). 216595027455 PS00211 ABC transporters family signature. 216595027456 hypothetical protein; Provisional; Region: PRK15301 216595027457 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 216595027458 pilin outer membrane usher protein SafC; Provisional; Region: PRK15223; cl14650 216595027459 PS00294 Prenyl group binding site (CAAX box). 216595027461 putative fimbrial chaperone protein; Provisional; Region: PRK09918 216595027462 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 216595027465 1 probable transmembrane helix predicted for PFLU5909 by TMHMM2.0 at aa 7-29 216595027466 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 216595027468 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 216595027469 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 216595027471 polyphosphate kinase; Provisional; Region: PRK05443 216595027472 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 216595027473 putative active site [active] 216595027474 catalytic site [active] 216595027475 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 216595027476 putative domain interface [polypeptide binding]; other site 216595027477 putative active site [active] 216595027478 catalytic site [active] 216595027480 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 216595027481 dimer interface [polypeptide binding]; other site 216595027482 active site 216595027483 aspartate-rich active site metal binding site; other site 216595027484 allosteric magnesium binding site [ion binding]; other site 216595027485 Schiff base residues; other site 216595027487 PS00169 Delta-aminolevulinic acid dehydratase active site. 216595027488 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 216595027489 5 probable transmembrane helices predicted for PFLU5914 by TMHMM2.0 at aa 11-33, 40-62, 93-115, 122-144 and 159-176 216595027490 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 216595027491 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 216595027492 conserved cys residue [active] 216595027494 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 216595027496 Cytochrome c; Region: Cytochrom_C; cl11414 216595027497 Iron permease FTR1 family; Region: FTR1; cl00475 216595027500 PS00190 Cytochrome c family heme-binding site signature. 216595027501 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 216595027502 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595027504 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 216595027505 putative dimer interface [polypeptide binding]; other site 216595027507 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595027508 Curli production assembly/transport component CsgG; Region: CsgG; cl00639 216595027509 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595027510 LysE type translocator; Region: LysE; cl00565 216595027512 Mechanosensitive ion channel; Region: MS_channel; pfam00924 216595027514 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 216595027515 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595027516 Walker A/P-loop; other site 216595027517 ATP binding site [chemical binding]; other site 216595027518 Q-loop/lid; other site 216595027519 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 216595027520 ABC transporter signature motif; other site 216595027521 Walker B; other site 216595027522 D-loop; other site 216595027523 ABC transporter; Region: ABC_tran_2; pfam12848 216595027524 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 216595027526 PS00211 ABC transporters family signature. 216595027527 PS00017 ATP/GTP-binding site motif A (P-loop). 216595027529 PS00211 ABC transporters family signature. 216595027530 PS00017 ATP/GTP-binding site motif A (P-loop). 216595027531 Protein of unknown function (DUF2390); Region: DUF2390; cl02376 216595027532 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 216595027533 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 216595027534 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 216595027537 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 216595027538 PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2. 216595027539 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ; Region: Rsd_AlgQ; cl11478 216595027541 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 216595027542 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 216595027543 HemY protein N-terminus; Region: HemY_N; pfam07219 216595027545 HemX; Region: HemX; cl14667 216595027547 PS00215 Mitochondrial energy transfer proteins signature. 216595027548 1 probable transmembrane helix predicted for PFLU5932 by TMHMM2.0 at aa 30-52 216595027549 uroporphyrinogen-III synthase; Validated; Region: PRK05752 216595027550 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 216595027551 active site 216595027553 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 216595027554 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 216595027555 domain interfaces; other site 216595027556 active site 216595027558 PS00533 Porphobilinogen deaminase cofactor-binding site. 216595027560 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 216595027561 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595027562 active site 216595027563 phosphorylation site [posttranslational modification] 216595027564 intermolecular recognition site; other site 216595027565 dimerization interface [polypeptide binding]; other site 216595027566 LytTr DNA-binding domain; Region: LytTR; cl04498 216595027569 argininosuccinate lyase; Provisional; Region: PRK00855 216595027570 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 216595027571 active sites [active] 216595027572 tetramer interface [polypeptide binding]; other site 216595027574 PS00163 Fumarate lyases signature. 216595027575 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 216595027576 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 216595027577 C-terminal domain interface [polypeptide binding]; other site 216595027578 GSH binding site (G-site) [chemical binding]; other site 216595027579 dimer interface [polypeptide binding]; other site 216595027580 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 216595027581 N-terminal domain interface [polypeptide binding]; other site 216595027582 dimer interface [polypeptide binding]; other site 216595027583 substrate binding pocket (H-site) [chemical binding]; other site 216595027585 Phosphate-starvation-inducible E; Region: PsiE; cl01264 216595027586 adenylate cyclase; Provisional; Region: cyaA; PRK09450 216595027587 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 216595027588 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 216595027590 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 216595027591 C-term; Region: GreA_GreB; pfam01272 216595027592 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 216595027594 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in...; Region: Frataxin; cl00238 216595027595 putative iron binding site [ion binding]; other site 216595027597 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595027598 diaminopimelate decarboxylase; Region: lysA; TIGR01048 216595027599 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 216595027600 active site 216595027601 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 216595027602 substrate binding site [chemical binding]; other site 216595027603 catalytic residues [active] 216595027604 dimer interface [polypeptide binding]; other site 216595027606 PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site. 216595027607 PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2. 216595027609 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 216595027610 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 216595027611 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 216595027613 PS01326 Diaminopimelate epimerase signature. 216595027614 PS00017 ATP/GTP-binding site motif A (P-loop). 216595027616 Protein of unknown function, DUF484; Region: DUF484; cl01228 216595027618 PS00017 ATP/GTP-binding site motif A (P-loop). 216595027619 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 216595027620 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 216595027621 DNA binding site [nucleotide binding] 216595027622 Int/Topo IB signature motif; other site 216595027623 active site 216595027626 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 216595027627 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 216595027628 motif II; other site 216595027630 Uncharacterised protein family UPF0047; Region: UPF0047; cl00439 216595027632 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 216595027634 PS01219 Ammonium transporters signature. 216595027635 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595027636 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 216595027638 PS00638 P-II protein C-terminal region signature. 216595027639 PS00496 P-II protein urydylation site. 216595027640 Membrane fusogenic activity; Region: BMFP; cl01115 216595027642 3 probable transmembrane helices predicted for PFLU5955 by TMHMM2.0 at aa 37-54, 61-80 and 84-106 216595027643 Mg chelatase-related protein; Region: TIGR00368 216595027644 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 216595027645 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595027647 PS00017 ATP/GTP-binding site motif A (P-loop). 216595027648 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 216595027649 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 216595027650 dimerization interface [polypeptide binding]; other site 216595027651 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 216595027655 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 216595027656 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595027657 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595027658 dimerization interface [polypeptide binding]; other site 216595027661 PS00044 Bacterial regulatory proteins, lysR family signature. 216595027662 multidrug efflux protein NorA; Provisional; Region: PRK00187 216595027663 MatE; Region: MatE; cl10513 216595027664 MatE; Region: MatE; cl10513 216595027665 12 probable transmembrane helices predicted for PFLU5959 by TMHMM2.0 at aa 9-31, 51-73, 93-110, 125-147, 160-179, 189-211, 239-261, 271-293, 313-335, 350-372, 393-415 and 419-441 216595027668 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216595027669 metal binding site [ion binding]; metal-binding site 216595027670 active site 216595027671 I-site; other site 216595027672 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216595027675 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 216595027676 UvrD/REP helicase; Region: UvrD-helicase; cl14126 216595027678 PS00017 ATP/GTP-binding site motif A (P-loop). 216595027679 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 216595027682 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 216595027683 Cytochrome c; Region: Cytochrom_C; cl11414 216595027684 PS00190 Cytochrome c family heme-binding site signature. 216595027685 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 216595027686 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216595027687 non-specific DNA binding site [nucleotide binding]; other site 216595027688 salt bridge; other site 216595027689 sequence-specific DNA binding site [nucleotide binding]; other site 216595027690 Cupin domain; Region: Cupin_2; cl09118 216595027693 alanine racemase; Reviewed; Region: dadX; PRK03646 216595027694 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 216595027695 active site 216595027696 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 216595027697 substrate binding site [chemical binding]; other site 216595027698 catalytic residues [active] 216595027699 dimer interface [polypeptide binding]; other site 216595027702 PS00395 Alanine racemase pyridoxal-phosphate attachment site. 216595027703 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 216595027704 homotrimer interaction site [polypeptide binding]; other site 216595027705 putative active site [active] 216595027707 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 216595027708 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409 216595027710 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595027711 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 216595027712 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595027713 PS00519 Bacterial regulatory proteins, asnC family signature. 216595027715 Flagellin N-methylase; Region: FliB; cl00497 216595027717 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 216595027718 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 216595027720 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 216595027721 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595027722 DNA-binding site [nucleotide binding]; DNA binding site 216595027723 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216595027724 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595027725 homodimer interface [polypeptide binding]; other site 216595027726 catalytic residue [active] 216595027729 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 216595027730 putative active site [active] 216595027731 catalytic site [active] 216595027732 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 216595027733 putative active site [active] 216595027734 catalytic site [active] 216595027735 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595027738 enterobactin exporter EntS; Provisional; Region: PRK10489 216595027740 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 216595027741 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 216595027742 NAD(P) binding site [chemical binding]; other site 216595027743 catalytic residues [active] 216595027745 PS00070 Aldehyde dehydrogenases cysteine active site. 216595027746 PS00687 Aldehyde dehydrogenases glutamic acid active site. 216595027747 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595027748 Cupin domain; Region: Cupin_2; cl09118 216595027750 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 216595027752 PS00228 Tubulin-beta mRNA autoregulation signal. 216595027753 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 216595027755 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 216595027756 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 216595027757 peptide binding site [polypeptide binding]; other site 216595027759 hypothetical protein; Reviewed; Region: PRK00024 216595027760 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 216595027761 MPN+ (JAMM) motif; other site 216595027762 Zinc-binding site [ion binding]; other site 216595027764 PS01302 DNA repair protein radC family signature. 216595027765 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 216595027766 Flavoprotein; Region: Flavoprotein; cl08021 216595027767 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 216595027769 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595027771 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 216595027772 trimer interface [polypeptide binding]; other site 216595027773 active site 216595027775 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 216595027776 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 216595027777 active site 216595027778 substrate binding site [chemical binding]; other site 216595027779 metal binding site [ion binding]; metal-binding site 216595027781 PS00017 ATP/GTP-binding site motif A (P-loop). 216595027782 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 216595027786 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using...; Region: AAK_NAGK-C; cd04250 216595027787 feedback inhibition sensing region; other site 216595027788 homohexameric interface [polypeptide binding]; other site 216595027789 nucleotide binding site [chemical binding]; other site 216595027790 N-acetyl-L-glutamate binding site [chemical binding]; other site 216595027792 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 216595027794 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 216595027795 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 216595027796 putative active site [active] 216595027797 putative DNA binding site [nucleotide binding]; other site 216595027798 putative phosphate binding site [ion binding]; other site 216595027799 putative catalytic site [active] 216595027800 metal binding site A [ion binding]; metal-binding site 216595027801 putative AP binding site [nucleotide binding]; other site 216595027802 putative metal binding site B [ion binding]; other site 216595027804 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 216595027805 ribonuclease PH; Reviewed; Region: rph; PRK00173 216595027806 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 216595027807 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 216595027810 PS01277 Ribonuclease PH signature. 216595027811 hypothetical protein; Provisional; Region: PRK11820 216595027812 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 216595027813 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 216595027816 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 216595027817 catalytic site [active] 216595027818 G-X2-G-X-G-K; other site 216595027819 PS00017 ATP/GTP-binding site motif A (P-loop). 216595027820 PS00856 Guanylate kinase signature. 216595027822 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 216595027824 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 216595027825 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 216595027826 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 216595027827 synthetase active site [active] 216595027828 NTP binding site [chemical binding]; other site 216595027829 metal binding site [ion binding]; metal-binding site 216595027830 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 216595027831 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 216595027835 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 216595027836 homotrimer interaction site [polypeptide binding]; other site 216595027837 putative active site [active] 216595027839 PS01094 Uncharacterized protein family UPF0076 signature. 216595027840 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595027842 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216595027843 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 216595027844 putative NAD(P) binding site [chemical binding]; other site 216595027846 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 216595027847 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 216595027848 4 probable transmembrane helices predicted for PFLU5999 by TMHMM2.0 at aa 20-39, 104-126, 212-234 and 258-280 216595027850 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 216595027852 1 probable transmembrane helix predicted for PFLU6000 by TMHMM2.0 at aa 20-42 216595027853 Gram-negative bacterial tonB protein; Region: TonB; cl10048 216595027854 1 probable transmembrane helix predicted for PFLU6001 by TMHMM2.0 at aa 13-35 216595027855 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 216595027856 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595027857 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 216595027858 dimerization interface [polypeptide binding]; other site 216595027860 PS00044 Bacterial regulatory proteins, lysR family signature. 216595027862 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 216595027863 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 216595027864 generic binding surface II; other site 216595027865 ssDNA binding site; other site 216595027866 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216595027867 ATP binding site [chemical binding]; other site 216595027868 putative Mg++ binding site [ion binding]; other site 216595027869 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216595027870 nucleotide binding region [chemical binding]; other site 216595027871 ATP-binding site [chemical binding]; other site 216595027874 PS00017 ATP/GTP-binding site motif A (P-loop). 216595027876 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 216595027877 putative deacylase active site [active] 216595027878 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 216595027879 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 216595027882 PS00024 Hemopexin domain signature. 216595027884 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 216595027887 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 216595027888 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595027889 Walker A/P-loop; other site 216595027890 ATP binding site [chemical binding]; other site 216595027891 Q-loop/lid; other site 216595027892 ABC transporter signature motif; other site 216595027893 Walker B; other site 216595027894 D-loop; other site 216595027895 H-loop/switch region; other site 216595027897 PS00017 ATP/GTP-binding site motif A (P-loop). 216595027898 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 216595027899 Catalytic domain of Protein Kinases; Region: PKc; cd00180 216595027900 active site 216595027901 ATP binding site [chemical binding]; other site 216595027902 substrate binding site [chemical binding]; other site 216595027903 activation loop (A-loop); other site 216595027904 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 216595027905 metal ion-dependent adhesion site (MIDAS); other site 216595027906 1 probable transmembrane helix predicted for PFLU6010 by TMHMM2.0 at aa 325-347 216595027908 PS00108 Serine/Threonine protein kinases active-site signature. 216595027909 PS00107 Protein kinases ATP-binding region signature. 216595027910 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 216595027911 Protein phosphatase 2C; Region: PP2C; pfam00481 216595027912 Active site [active] 216595027914 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 216595027915 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 216595027916 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 216595027917 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 216595027920 PS00017 ATP/GTP-binding site motif A (P-loop). 216595027921 hypothetical protein; Provisional; Region: PRK07033 216595027922 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 216595027923 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216595027924 ligand binding site [chemical binding]; other site 216595027926 1 probable transmembrane helix predicted for PFLU6014 by TMHMM2.0 at aa 223-245 216595027927 PS00017 ATP/GTP-binding site motif A (P-loop). 216595027928 Bacterial protein of unknown function (DUF876); Region: DUF876; cl01406 216595027930 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 216595027931 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595027932 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 216595027933 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 216595027934 phosphopeptide binding site; other site 216595027936 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 216595027937 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 216595027939 Protein of unknown function (DUF770); Region: DUF770; cl01402 216595027941 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 216595027942 Protein of unknown function (DUF877); Region: DUF877; pfam05943 216595027944 Protein of unknown function (DUF796); Region: DUF796; cl01226 216595027946 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 216595027948 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 216595027949 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 216595027951 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 216595027953 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 216595027954 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595027955 Walker A motif; other site 216595027956 ATP binding site [chemical binding]; other site 216595027957 Walker B motif; other site 216595027958 arginine finger; other site 216595027959 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 216595027960 Walker A motif; other site 216595027961 ATP binding site [chemical binding]; other site 216595027962 Walker B motif; other site 216595027963 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 216595027966 PS00017 ATP/GTP-binding site motif A (P-loop). 216595027967 PS00870 Chaperonins clpA/B signature 1. 216595027969 PS00017 ATP/GTP-binding site motif A (P-loop). 216595027970 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 216595027971 Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432 216595027973 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 216595027975 Uncharacterized conserved protein [Function unknown]; Region: COG4104 216595027976 PAAR motif; Region: PAAR_motif; pfam05488 216595027977 RHS Repeat; Region: RHS_repeat; cl11982 216595027978 RHS Repeat; Region: RHS_repeat; cl11982 216595027979 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 216595027980 RHS Repeat; Region: RHS_repeat; cl11982 216595027981 RHS Repeat; Region: RHS_repeat; cl11982 216595027982 RHS protein; Region: RHS; pfam03527 216595027983 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 216595027984 RES domain; Region: RES; cl02411 216595027985 2 probable transmembrane helices predicted for PFLU6028 by TMHMM2.0 at aa 24-46 and 53-75 216595028002 Uncharacterized conserved protein [Function unknown]; Region: COG4104 216595028003 PAAR motif; Region: PAAR_motif; pfam05488 216595028004 RHS Repeat; Region: RHS_repeat; cl11982 216595028005 RHS Repeat; Region: RHS_repeat; cl11982 216595028006 RHS Repeat; Region: RHS_repeat; cl11982 216595028007 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 216595028008 RHS Repeat; Region: RHS_repeat; cl11982 216595028009 RHS Repeat; Region: RHS_repeat; cl11982 216595028010 RHS Repeat; Region: RHS_repeat; cl11982 216595028011 RHS protein; Region: RHS; pfam03527 216595028012 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 216595028014 2 probable transmembrane helices predicted for PFLU6030 by TMHMM2.0 at aa 26-48 and 55-77 216595028030 Sel1 repeat; Region: Sel1; cl02723 216595028032 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 216595028033 IHF - DNA interface [nucleotide binding]; other site 216595028034 IHF dimer interface [polypeptide binding]; other site 216595028036 PS00045 Bacterial histone-like DNA-binding proteins signature. 216595028037 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 216595028040 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595028041 Rubredoxin [Energy production and conversion]; Region: COG1773 216595028042 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They...; Region: rubredoxin; cd00730 216595028043 iron binding site [ion binding]; other site 216595028045 PS00202 Rubredoxin signature. 216595028046 UTRA domain; Region: UTRA; cl01230 216595028048 UbiA prenyltransferase family; Region: UbiA; cl00337 216595028049 7 probable transmembrane helices predicted for PFLU6036 by TMHMM2.0 at aa 29-46, 51-73, 102-124, 144-166, 173-195, 241-263 and 276-295 216595028051 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 216595028052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4315 216595028055 1 probable transmembrane helix predicted for PFLU6037 by TMHMM2.0 at aa 37-59 216595028056 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 216595028057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595028058 active site 216595028059 phosphorylation site [posttranslational modification] 216595028060 intermolecular recognition site; other site 216595028061 dimerization interface [polypeptide binding]; other site 216595028062 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 216595028063 DNA binding site [nucleotide binding] 216595028066 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 216595028067 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 216595028068 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 216595028069 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 216595028070 dimer interface [polypeptide binding]; other site 216595028071 phosphorylation site [posttranslational modification] 216595028072 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216595028073 ATP binding site [chemical binding]; other site 216595028074 Mg2+ binding site [ion binding]; other site 216595028075 G-X-G motif; other site 216595028076 1 probable transmembrane helix predicted for PFLU6040 by TMHMM2.0 at aa 21-43 216595028080 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 216595028081 Domain of unknown function DUF21; Region: DUF21; pfam01595 216595028082 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 216595028083 Transporter associated domain; Region: CorC_HlyC; cl08393 216595028084 4 probable transmembrane helices predicted for PFLU6041 by TMHMM2.0 at aa 36-58, 95-117, 137-159 and 172-194 216595028086 PS00192 Cytochrome b/b6 heme-ligand signature. 216595028089 Peptidase family M23; Region: Peptidase_M23; pfam01551 216595028091 Response regulator receiver domain; Region: Response_reg; pfam00072 216595028092 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 216595028093 active site 216595028094 phosphorylation site [posttranslational modification] 216595028095 intermolecular recognition site; other site 216595028096 dimerization interface [polypeptide binding]; other site 216595028098 transcriptional regulator PhoU; Provisional; Region: PRK11115 216595028099 PhoU domain; Region: PhoU; pfam01895 216595028100 PhoU domain; Region: PhoU; pfam01895 216595028103 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 216595028104 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 216595028105 Walker A/P-loop; other site 216595028106 ATP binding site [chemical binding]; other site 216595028107 Q-loop/lid; other site 216595028108 ABC transporter signature motif; other site 216595028109 Walker B; other site 216595028110 D-loop; other site 216595028111 H-loop/switch region; other site 216595028113 PS00211 ABC transporters family signature. 216595028114 PS00017 ATP/GTP-binding site motif A (P-loop). 216595028115 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 216595028116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 216595028117 dimer interface [polypeptide binding]; other site 216595028118 conserved gate region; other site 216595028119 putative PBP binding loops; other site 216595028120 ABC-ATPase subunit interface; other site 216595028122 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 216595028123 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 216595028124 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 216595028126 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595028127 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216595028128 metabolite-proton symporter; Region: 2A0106; TIGR00883 216595028129 putative substrate translocation pore; other site 216595028131 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain...; Region: BFIT_BACH; cd03442 216595028132 PS00213 Lipocalin signature. 216595028134 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 216595028135 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 216595028136 active site 216595028137 phosphate binding residues; other site 216595028138 catalytic residues [active] 216595028140 Protein of unknown function (DUF3299); Region: DUF3299; cl01387 216595028141 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 216595028143 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 216595028144 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 216595028146 AIR carboxylase; Region: AIRC; cl00310 216595028149 cell density-dependent motility repressor; Provisional; Region: PRK10082 216595028150 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595028151 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 216595028152 dimerization interface [polypeptide binding]; other site 216595028154 PS00435 Peroxidases proximal heme-ligand signature. 216595028156 PS00044 Bacterial regulatory proteins, lysR family signature. 216595028157 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 216595028158 Aspartase; Region: Aspartase; cd01357 216595028159 active sites [active] 216595028160 tetramer interface [polypeptide binding]; other site 216595028162 PS00163 Fumarate lyases signature. 216595028163 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 216595028164 10 probable transmembrane helices predicted for PFLU6058 by TMHMM2.0 at aa 26-45, 90-112, 156-178, 193-212, 219-241, 256-275, 310-332, 357-379, 400-419 and 423-440 216595028166 PS00873 Sodium:alanine symporter family signature. 216595028167 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 216595028168 Asparaginase (amidohydrolase): Asparaginases are tetrameric enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases, one highly specific for asparagine and localised to the...; Region: Asparaginase; cl00216 216595028169 active site/substrate binding site [active] 216595028170 tetramer interface [polypeptide binding]; other site 216595028172 PS00144 Asparaginase / glutaminase active site signature 1. 216595028173 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 216595028174 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216595028176 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 216595028177 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 216595028179 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 216595028180 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216595028182 PS00017 ATP/GTP-binding site motif A (P-loop). 216595028183 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 216595028184 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216595028185 DNA-binding site [nucleotide binding]; DNA binding site 216595028186 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216595028187 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216595028188 homodimer interface [polypeptide binding]; other site 216595028189 catalytic residue [active] 216595028191 PS00626 Regulator of chromosome condensation (RCC1) signature 2. 216595028193 PS00043 Bacterial regulatory proteins, gntR family signature. 216595028194 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 216595028196 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 216595028197 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216595028198 Coenzyme A binding pocket [chemical binding]; other site 216595028200 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 216595028201 PS00019 Actinin-type actin-binding domain signature 1. 216595028205 pyruvate carboxylase subunit B; Validated; Region: PRK09282 216595028206 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 216595028207 active site 216595028208 catalytic residues [active] 216595028209 metal binding site [ion binding]; metal-binding site 216595028210 homodimer binding site [polypeptide binding]; other site 216595028211 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 216595028212 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 216595028213 carboxyltransferase (CT) interaction site; other site 216595028214 biotinylation site [posttranslational modification]; other site 216595028218 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 216595028219 pyruvate carboxylase subunit A; Validated; Region: PRK07178 216595028220 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 216595028221 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 216595028222 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 216595028225 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 216595028226 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 216595028228 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595028229 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 216595028230 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 216595028231 putative dimerization interface [polypeptide binding]; other site 216595028233 PS00044 Bacterial regulatory proteins, lysR family signature. 216595028235 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 216595028236 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 216595028237 putative active site [active] 216595028240 PAS fold; Region: PAS_3; pfam08447 216595028241 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 216595028242 PAS domain S-box; Region: sensory_box; TIGR00229 216595028243 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216595028244 putative active site [active] 216595028245 heme pocket [chemical binding]; other site 216595028246 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216595028247 metal binding site [ion binding]; metal-binding site 216595028248 active site 216595028249 I-site; other site 216595028250 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216595028255 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 216595028256 UvrD/REP helicase; Region: UvrD-helicase; cl14126 216595028258 PS00017 ATP/GTP-binding site motif A (P-loop). 216595028259 Tim44-like domain; Region: Tim44; cl09208 216595028260 2 probable transmembrane helices predicted for PFLU6076 by TMHMM2.0 at aa 74-96 and 101-120 216595028262 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 216595028263 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 216595028265 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain...; Region: BFIT_BACH; cd03442 216595028267 PS00017 ATP/GTP-binding site motif A (P-loop). 216595028268 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595028269 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 216595028270 pyridoxal binding site [chemical binding]; other site 216595028271 dimer interface [polypeptide binding]; other site 216595028272 ATP binding site [chemical binding]; other site 216595028273 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 216595028274 1 probable transmembrane helix predicted for PFLU6082 by TMHMM2.0 at aa 4-26 216595028275 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 216595028276 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 216595028277 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 216595028280 PS00017 ATP/GTP-binding site motif A (P-loop). 216595028281 Protein of unknown function (DUF1826); Region: DUF1826; pfam08856 216595028283 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 216595028284 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 216595028285 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 216595028288 PS00017 ATP/GTP-binding site motif A (P-loop). 216595028289 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 216595028291 Localisation of periplasmic protein complexes; Region: AMIN; pfam11741 216595028292 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 216595028293 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 216595028294 active site 216595028295 metal binding site [ion binding]; metal-binding site 216595028297 Uncharacterized ACR, COG1469; Region: DUF198; cl00642 216595028299 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 216595028300 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 216595028301 Walker A/P-loop; other site 216595028302 ATP binding site [chemical binding]; other site 216595028303 Q-loop/lid; other site 216595028304 ABC transporter signature motif; other site 216595028305 Walker B; other site 216595028306 D-loop; other site 216595028307 H-loop/switch region; other site 216595028309 PS00017 ATP/GTP-binding site motif A (P-loop). 216595028310 PS00211 ABC transporters family signature. 216595028311 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 216595028312 ABC-ATPase subunit interface; other site 216595028313 dimer interface [polypeptide binding]; other site 216595028314 putative PBP binding regions; other site 216595028316 8 probable transmembrane helices predicted for PFLU6090 by TMHMM2.0 at aa 15-37, 44-66, 71-90, 102-121, 143-165, 186-208, 228-250 and 257-279 216595028317 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 216595028318 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 216595028319 metal binding site [ion binding]; metal-binding site 216595028321 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 216595028323 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 216595028324 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide...; Region: LbH_gamma_CA; cd00710 216595028325 trimer interface [polypeptide binding]; other site 216595028326 active site 216595028331 dihydroorotase; Reviewed; Region: PRK09236 216595028332 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 216595028333 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 216595028334 active site 216595028335 PS00483 Dihydroorotase signature 2. 216595028337 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 216595028338 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 216595028339 Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155 216595028340 putative active site [active] 216595028341 catalytic site [active] 216595028342 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 216595028343 putative active site [active] 216595028344 catalytic site [active] 216595028345 2 probable transmembrane helices predicted for PFLU6096 by TMHMM2.0 at aa 15-37 and 44-66 216595028348 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 216595028349 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 216595028350 S-adenosylmethionine binding site [chemical binding]; other site 216595028352 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 216595028353 hypothetical protein; Provisional; Region: PRK05409 216595028354 Protein of unknown function (DUF692); Region: DUF692; cl01263 216595028356 Predicted integral membrane protein (DUF2282); Region: DUF2282; cl02366 216595028357 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 216595028358 1 probable transmembrane helix predicted for PFLU6100 by TMHMM2.0 at aa 7-29 216595028359 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 216595028360 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216595028362 PS00154 E1-E2 ATPases phosphorylation site. 216595028364 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 216595028365 HflK protein; Region: hflK; TIGR01933 216595028367 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 216595028368 HflK protein; Region: hflK; TIGR01933 216595028370 1 probable transmembrane helix predicted for PFLU6103 by TMHMM2.0 at aa 32-51 216595028371 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 216595028372 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 216595028373 4 probable transmembrane helices predicted for PFLU6105 by TMHMM2.0 at aa 34-56, 112-134, 154-171 and 176-193 216595028375 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 216595028376 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 216595028377 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 216595028379 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 216595028380 active site 216595028381 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 216595028382 Dual specificity phosphatase, catalytic domain; Region: DSPc; pfam00782 216595028383 active site 216595028384 catalytic residues [active] 216595028385 7 probable transmembrane helices predicted for PFLU6107 by TMHMM2.0 at aa 9-31, 51-73, 86-105, 128-147, 154-176, 186-208 and 221-243 216595028388 2 probable transmembrane helices predicted for PFLU6108 by TMHMM2.0 at aa 39-61 and 123-145 216595028389 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 216595028390 putative acyl-acceptor binding pocket; other site 216595028392 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 216595028393 9 probable transmembrane helices predicted for PFLU6110 by TMHMM2.0 at aa 15-37, 57-90, 105-122, 127-149, 164-186, 191-213, 233-250, 257-279 and 299-321 216595028395 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 216595028396 MG2 domain; Region: A2M_N; pfam01835 216595028397 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 216595028398 Alpha-2-macroglobulin family; Region: A2M; pfam00207 216595028399 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 216595028400 surface patch; other site 216595028401 thioester region; other site 216595028402 1 probable transmembrane helix predicted for PFLU6111 by TMHMM2.0 at aa 54-76 216595028405 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 216595028406 Transglycosylase; Region: Transgly; cl07896 216595028407 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 216595028408 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 216595028412 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 216595028413 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714 216595028414 glutaminase active site [active] 216595028415 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 216595028416 dimer interface [polypeptide binding]; other site 216595028417 active site 216595028418 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 216595028419 dimer interface [polypeptide binding]; other site 216595028420 active site 216595028424 PS00443 Glutamine amidotransferases class-II active site. 216595028425 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 216595028426 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 216595028427 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 216595028430 PS00894 Bacterial regulatory proteins, deoR family signature. 216595028432 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 216595028433 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 216595028434 Substrate binding site [chemical binding]; other site 216595028435 Mg++ binding site [ion binding]; other site 216595028436 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 216595028437 active site 216595028438 substrate binding site [chemical binding]; other site 216595028439 CoA binding site [chemical binding]; other site 216595028449 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 216595028450 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 216595028451 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 216595028453 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 216595028454 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 216595028455 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 216595028456 alpha subunit interaction interface [polypeptide binding]; other site 216595028457 Walker A motif; other site 216595028458 ATP binding site [chemical binding]; other site 216595028459 Walker B motif; other site 216595028460 inhibitor binding site; inhibition site 216595028461 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 216595028464 PS00152 ATP synthase alpha and beta subunits signature. 216595028465 PS00017 ATP/GTP-binding site motif A (P-loop). 216595028467 ATP synthase; Region: ATP-synt; cl00365 216595028469 PS00153 ATP synthase gamma subunit signature. 216595028470 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 216595028471 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 216595028472 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 216595028473 beta subunit interaction interface [polypeptide binding]; other site 216595028474 Walker A motif; other site 216595028475 ATP binding site [chemical binding]; other site 216595028476 Walker B motif; other site 216595028477 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 216595028480 PS00152 ATP synthase alpha and beta subunits signature. 216595028481 PS00017 ATP/GTP-binding site motif A (P-loop). 216595028483 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 216595028484 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 216595028486 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 216595028487 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 216595028489 1 probable transmembrane helix predicted for PFLU6122 by TMHMM2.0 at aa 12-34 216595028490 ATP synthase subunit C; Region: ATP-synt_C; cl00466 216595028492 PS00605 ATP synthase c subunit signature. 216595028493 ATP synthase A chain; Region: ATP-synt_A; cl00413 216595028495 PS00449 ATP synthase a subunit signature. 216595028496 ATP synthase I chain; Region: ATP_synt_I; cl09170 216595028498 ParB-like partition proteins; Region: parB_part; TIGR00180 216595028499 ParB-like nuclease domain; Region: ParBc; cl02129 216595028501 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 216595028502 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 216595028503 P-loop; other site 216595028504 Magnesium ion binding site [ion binding]; other site 216595028505 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 216595028506 Magnesium ion binding site [ion binding]; other site 216595028508 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 216595028509 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 216595028511 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216595028512 Flavin-dependent tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Cell cycle control, cell division, chromosome partitioning]; Region: GidA; COG0445 216595028514 PS01281 Glucose inhibited division protein A family signature 2. 216595028515 PS01280 Glucose inhibited division protein A family signature 1. 216595028516 PS00017 ATP/GTP-binding site motif A (P-loop). 216595028517 low G+C content region (42.88%) 216595028518 RNA polymerase sigma factor; Provisional; Region: PRK12528 216595028519 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216595028520 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 216595028521 DNA binding residues [nucleotide binding] 216595028524 fec operon regulator FecR; Reviewed; Region: PRK09774 216595028525 FecR protein; Region: FecR; pfam04773 216595028527 Secretin and TonB N terminus short domain; Region: STN; cl06624 216595028528 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 216595028529 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216595028530 N-terminal plug; other site 216595028531 ligand-binding site [chemical binding]; other site 216595028535 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 216595028536 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 216595028537 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 216595028538 G1 box; other site 216595028539 GTP/Mg2+ binding site [chemical binding]; other site 216595028540 Switch I region; other site 216595028541 G2 box; other site 216595028542 Switch II region; other site 216595028543 G3 box; other site 216595028544 G4 box; other site 216595028545 G5 box; other site 216595028546 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 216595028548 PS00017 ATP/GTP-binding site motif A (P-loop). 216595028549 membrane protein insertase; Provisional; Region: PRK01318 216595028550 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 216595028552 Ribonuclease P; Region: Ribonuclease_P; cl00457 216595028554 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 216595028556 PS00784 Ribosomal protein L34 signature.