-- dump date 20140620_005601 -- class Genbank::misc_feature -- table misc_feature_note -- id note 743720000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 743720000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720000003 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 743720000004 Walker A motif; other site 743720000005 ATP binding site [chemical binding]; other site 743720000006 Walker B motif; other site 743720000007 arginine finger; other site 743720000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 743720000009 DnaA box-binding interface [nucleotide binding]; other site 743720000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 743720000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 743720000012 putative DNA binding surface [nucleotide binding]; other site 743720000013 dimer interface [polypeptide binding]; other site 743720000014 beta-clamp/clamp loader binding surface; other site 743720000015 beta-clamp/translesion DNA polymerase binding surface; other site 743720000016 recombination protein F; Reviewed; Region: recF; PRK00064 743720000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743720000018 Walker A/P-loop; other site 743720000019 ATP binding site [chemical binding]; other site 743720000020 Q-loop/lid; other site 743720000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743720000022 ABC transporter signature motif; other site 743720000023 Walker B; other site 743720000024 D-loop; other site 743720000025 H-loop/switch region; other site 743720000026 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 743720000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720000028 Mg2+ binding site [ion binding]; other site 743720000029 G-X-G motif; other site 743720000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 743720000031 anchoring element; other site 743720000032 dimer interface [polypeptide binding]; other site 743720000033 ATP binding site [chemical binding]; other site 743720000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 743720000035 active site 743720000036 putative metal-binding site [ion binding]; other site 743720000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 743720000038 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 743720000039 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 743720000040 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 743720000041 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 743720000042 putative acyl-acceptor binding pocket; other site 743720000043 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 743720000044 active site 743720000045 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 743720000046 active site 743720000047 catalytic residues [active] 743720000048 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 743720000049 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 743720000050 Putative methyltransferase; Region: Methyltransf_20; pfam12147 743720000051 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 743720000052 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 743720000053 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 743720000054 putative acyl-acceptor binding pocket; other site 743720000055 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 743720000056 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743720000057 active site 743720000058 motif I; other site 743720000059 motif II; other site 743720000060 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 743720000061 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 743720000062 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 743720000063 dimer interface [polypeptide binding]; other site 743720000064 motif 1; other site 743720000065 active site 743720000066 motif 2; other site 743720000067 motif 3; other site 743720000068 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 743720000069 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 743720000070 Protein of unknown function (DUF3649); Region: DUF3649; pfam12365 743720000071 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 743720000072 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 743720000073 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 743720000074 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 743720000075 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 743720000076 putative acyl-acceptor binding pocket; other site 743720000077 PilZ domain; Region: PilZ; pfam07238 743720000078 ectoine/hydroxyectoine ABC transporter, ATP-binding protein; Region: ectoine_ehuA; TIGR03005 743720000079 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 743720000080 Walker A/P-loop; other site 743720000081 ATP binding site [chemical binding]; other site 743720000082 Q-loop/lid; other site 743720000083 ABC transporter signature motif; other site 743720000084 Walker B; other site 743720000085 D-loop; other site 743720000086 H-loop/switch region; other site 743720000087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720000088 dimer interface [polypeptide binding]; other site 743720000089 conserved gate region; other site 743720000090 putative PBP binding loops; other site 743720000091 ABC-ATPase subunit interface; other site 743720000092 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 743720000093 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720000094 dimer interface [polypeptide binding]; other site 743720000095 conserved gate region; other site 743720000096 putative PBP binding loops; other site 743720000097 ABC-ATPase subunit interface; other site 743720000098 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 743720000099 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720000100 substrate binding pocket [chemical binding]; other site 743720000101 membrane-bound complex binding site; other site 743720000102 hinge residues; other site 743720000103 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 743720000104 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720000105 DNA-binding site [nucleotide binding]; DNA binding site 743720000106 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743720000107 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720000108 homodimer interface [polypeptide binding]; other site 743720000109 catalytic residue [active] 743720000110 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 743720000111 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 743720000112 tetramer interface [polypeptide binding]; other site 743720000113 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720000114 catalytic residue [active] 743720000115 ectoine utilization protein EutC; Validated; Region: PRK08291 743720000116 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 743720000117 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 743720000118 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 743720000119 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 743720000120 active site 743720000121 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 743720000122 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 743720000123 putative active site [active] 743720000124 Zn binding site [ion binding]; other site 743720000125 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 743720000126 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 743720000127 putative DNA binding site [nucleotide binding]; other site 743720000128 putative Zn2+ binding site [ion binding]; other site 743720000129 AsnC family; Region: AsnC_trans_reg; pfam01037 743720000130 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 743720000131 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 743720000132 Protein of unknown function (DUF1175); Region: DUF1175; cl14898 743720000133 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 743720000134 NlpC/P60 family; Region: NLPC_P60; pfam00877 743720000135 hypothetical protein; Provisional; Region: PRK11212 743720000136 succinic semialdehyde dehydrogenase; Region: PLN02278 743720000137 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 743720000138 tetramerization interface [polypeptide binding]; other site 743720000139 NAD(P) binding site [chemical binding]; other site 743720000140 catalytic residues [active] 743720000141 hypothetical protein; Provisional; Region: PRK07482 743720000142 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 743720000143 inhibitor-cofactor binding pocket; inhibition site 743720000144 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720000145 catalytic residue [active] 743720000146 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 743720000147 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720000148 putative substrate translocation pore; other site 743720000149 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 743720000150 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720000151 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 743720000152 dimerization interface [polypeptide binding]; other site 743720000153 substrate binding pocket [chemical binding]; other site 743720000154 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720000155 dimerization interface [polypeptide binding]; other site 743720000156 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720000157 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720000158 dimer interface [polypeptide binding]; other site 743720000159 putative CheW interface [polypeptide binding]; other site 743720000160 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743720000161 TPR motif; other site 743720000162 TPR repeat; Region: TPR_11; pfam13414 743720000163 binding surface 743720000164 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 743720000165 TrkA-N domain; Region: TrkA_N; pfam02254 743720000166 TrkA-C domain; Region: TrkA_C; pfam02080 743720000167 TrkA-N domain; Region: TrkA_N; pfam02254 743720000168 TrkA-C domain; Region: TrkA_C; pfam02080 743720000169 16S rRNA methyltransferase B; Provisional; Region: PRK10901 743720000170 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 743720000171 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720000172 S-adenosylmethionine binding site [chemical binding]; other site 743720000173 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 743720000174 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 743720000175 putative active site [active] 743720000176 substrate binding site [chemical binding]; other site 743720000177 putative cosubstrate binding site; other site 743720000178 catalytic site [active] 743720000179 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 743720000180 substrate binding site [chemical binding]; other site 743720000181 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 743720000182 active site 743720000183 catalytic residues [active] 743720000184 metal binding site [ion binding]; metal-binding site 743720000185 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 743720000186 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 743720000187 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 743720000188 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 743720000189 DNA protecting protein DprA; Region: dprA; TIGR00732 743720000190 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 743720000191 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 743720000192 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 743720000193 NADP binding site [chemical binding]; other site 743720000194 dimer interface [polypeptide binding]; other site 743720000195 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 743720000196 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 743720000197 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 743720000198 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 743720000199 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 743720000200 shikimate binding site; other site 743720000201 NAD(P) binding site [chemical binding]; other site 743720000202 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 743720000203 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 743720000204 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 743720000205 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 743720000206 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 743720000207 active site 743720000208 SAM binding site [chemical binding]; other site 743720000209 homodimer interface [polypeptide binding]; other site 743720000210 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 743720000211 active site 743720000212 SAM binding site [chemical binding]; other site 743720000213 homodimer interface [polypeptide binding]; other site 743720000214 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 743720000215 Precorrin-8X methylmutase; Region: CbiC; pfam02570 743720000216 precorrin-3B synthase; Region: CobG; TIGR02435 743720000217 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 743720000218 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 743720000219 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 743720000220 active site 743720000221 putative homodimer interface [polypeptide binding]; other site 743720000222 SAM binding site [chemical binding]; other site 743720000223 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 743720000224 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720000225 S-adenosylmethionine binding site [chemical binding]; other site 743720000226 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 743720000227 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 743720000228 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 743720000229 dimer interface [polypeptide binding]; other site 743720000230 [2Fe-2S] cluster binding site [ion binding]; other site 743720000231 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 743720000232 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720000233 dimer interface [polypeptide binding]; other site 743720000234 phosphorylation site [posttranslational modification] 743720000235 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720000236 ATP binding site [chemical binding]; other site 743720000237 Mg2+ binding site [ion binding]; other site 743720000238 G-X-G motif; other site 743720000239 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 743720000240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720000241 active site 743720000242 phosphorylation site [posttranslational modification] 743720000243 intermolecular recognition site; other site 743720000244 dimerization interface [polypeptide binding]; other site 743720000245 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720000246 Walker A motif; other site 743720000247 ATP binding site [chemical binding]; other site 743720000248 Walker B motif; other site 743720000249 arginine finger; other site 743720000250 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 743720000251 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 743720000252 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720000253 substrate binding pocket [chemical binding]; other site 743720000254 membrane-bound complex binding site; other site 743720000255 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 743720000256 DctM-like transporters; Region: DctM; pfam06808 743720000257 Domain of unknown function (DUF1850); Region: DUF1850; cl01950 743720000258 Ion transport protein; Region: Ion_trans; pfam00520 743720000259 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720000260 Coenzyme A binding pocket [chemical binding]; other site 743720000261 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 743720000262 transcriptional repressor UlaR; Provisional; Region: PRK13509 743720000263 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 743720000264 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 743720000265 short chain dehydrogenase; Provisional; Region: PRK07577 743720000266 classical (c) SDRs; Region: SDR_c; cd05233 743720000267 NAD(P) binding site [chemical binding]; other site 743720000268 active site 743720000269 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 743720000270 BNR repeat-like domain; Region: BNR_2; pfam13088 743720000271 putative transporter; Provisional; Region: PRK10484 743720000272 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 743720000273 Na binding site [ion binding]; other site 743720000274 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 743720000275 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 743720000276 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 743720000277 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 743720000278 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 743720000279 putative active site [active] 743720000280 metal binding site [ion binding]; metal-binding site 743720000281 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 743720000282 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 743720000283 inhibitor site; inhibition site 743720000284 active site 743720000285 dimer interface [polypeptide binding]; other site 743720000286 catalytic residue [active] 743720000287 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 743720000288 Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155 743720000289 putative active site [active] 743720000290 catalytic site [active] 743720000291 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 743720000292 putative active site [active] 743720000293 catalytic site [active] 743720000294 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 743720000295 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 743720000296 Na binding site [ion binding]; other site 743720000297 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 743720000298 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 743720000299 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 743720000300 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 743720000301 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 743720000302 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743720000303 Walker A/P-loop; other site 743720000304 ATP binding site [chemical binding]; other site 743720000305 Q-loop/lid; other site 743720000306 ABC transporter signature motif; other site 743720000307 Walker B; other site 743720000308 D-loop; other site 743720000309 H-loop/switch region; other site 743720000310 TOBE domain; Region: TOBE_2; pfam08402 743720000311 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 743720000312 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720000313 dimer interface [polypeptide binding]; other site 743720000314 conserved gate region; other site 743720000315 putative PBP binding loops; other site 743720000316 ABC-ATPase subunit interface; other site 743720000317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720000318 dimer interface [polypeptide binding]; other site 743720000319 conserved gate region; other site 743720000320 putative PBP binding loops; other site 743720000321 ABC-ATPase subunit interface; other site 743720000322 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 743720000323 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 743720000324 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK12485 743720000325 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 743720000326 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 743720000327 dimerization interface [polypeptide binding]; other site 743720000328 active site 743720000329 Uncharacterized conserved protein [Function unknown]; Region: COG5470 743720000330 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 743720000331 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 743720000332 substrate binding site [chemical binding]; other site 743720000333 ATP binding site [chemical binding]; other site 743720000334 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 743720000335 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 743720000336 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 743720000337 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 743720000338 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720000339 DNA-binding site [nucleotide binding]; DNA binding site 743720000340 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 743720000341 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720000342 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720000343 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 743720000344 putative dimerization interface [polypeptide binding]; other site 743720000345 EamA-like transporter family; Region: EamA; pfam00892 743720000346 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 743720000347 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 743720000348 nudix motif; other site 743720000349 Transcriptional regulators [Transcription]; Region: GntR; COG1802 743720000350 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720000351 DNA-binding site [nucleotide binding]; DNA binding site 743720000352 FCD domain; Region: FCD; pfam07729 743720000353 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 743720000354 succinic semialdehyde dehydrogenase; Region: PLN02278 743720000355 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 743720000356 tetramerization interface [polypeptide binding]; other site 743720000357 NAD(P) binding site [chemical binding]; other site 743720000358 catalytic residues [active] 743720000359 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 743720000360 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 743720000361 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 743720000362 NAD(P) binding site [chemical binding]; other site 743720000363 catalytic residues [active] 743720000364 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 743720000365 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 743720000366 Amino acid synthesis; Region: AA_synth; pfam06684 743720000367 putative GTP cyclohydrolase; Provisional; Region: PRK13674 743720000368 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 743720000369 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 743720000370 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 743720000371 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 743720000372 Protein of unknown function (DUF1826); Region: DUF1826; pfam08856 743720000373 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 743720000374 active site 743720000375 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 743720000376 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 743720000377 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 743720000378 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 743720000379 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720000380 putative substrate translocation pore; other site 743720000381 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 743720000382 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720000383 active site 743720000384 phosphorylation site [posttranslational modification] 743720000385 intermolecular recognition site; other site 743720000386 dimerization interface [polypeptide binding]; other site 743720000387 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720000388 Walker A motif; other site 743720000389 ATP binding site [chemical binding]; other site 743720000390 Walker B motif; other site 743720000391 arginine finger; other site 743720000392 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 743720000393 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 743720000394 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720000395 dimer interface [polypeptide binding]; other site 743720000396 phosphorylation site [posttranslational modification] 743720000397 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720000398 ATP binding site [chemical binding]; other site 743720000399 Mg2+ binding site [ion binding]; other site 743720000400 G-X-G motif; other site 743720000401 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 743720000402 putative cation:proton antiport protein; Provisional; Region: PRK10669 743720000403 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 743720000404 TrkA-N domain; Region: TrkA_N; pfam02254 743720000405 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 743720000406 Tetratricopeptide repeat; Region: TPR_12; pfam13424 743720000407 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 743720000408 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 743720000409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 743720000410 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 743720000411 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 743720000412 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 743720000413 Part of AAA domain; Region: AAA_19; pfam13245 743720000414 Family description; Region: UvrD_C_2; pfam13538 743720000415 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 743720000416 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 743720000417 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 743720000418 haemagglutination activity domain; Region: Haemagg_act; pfam05860 743720000419 adhesin HecA family 20-residue repeat (two copies); Region: fil_hemag_20aa; TIGR01731 743720000420 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 743720000421 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 743720000422 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 743720000423 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 743720000424 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 743720000425 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 743720000426 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 743720000427 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 743720000428 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 743720000429 active site 743720000430 catalytic residues [active] 743720000431 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 743720000432 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 743720000433 muropeptide transporter; Validated; Region: ampG; cl17669 743720000434 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 743720000435 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 743720000436 Sulfate transporter family; Region: Sulfate_transp; pfam00916 743720000437 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 743720000438 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 743720000439 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 743720000440 Sulfatase; Region: Sulfatase; cl17466 743720000441 choline-sulfatase; Region: chol_sulfatase; TIGR03417 743720000442 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 743720000443 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 743720000444 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720000445 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 743720000446 dimerization interface [polypeptide binding]; other site 743720000447 substrate binding pocket [chemical binding]; other site 743720000448 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883 743720000449 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 743720000450 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 743720000451 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 743720000452 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720000453 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720000454 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 743720000455 putative effector binding pocket; other site 743720000456 dimerization interface [polypeptide binding]; other site 743720000457 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 743720000458 NADH(P)-binding; Region: NAD_binding_10; pfam13460 743720000459 NAD binding site [chemical binding]; other site 743720000460 putative active site [active] 743720000461 substrate binding site [chemical binding]; other site 743720000462 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 743720000463 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 743720000464 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 743720000465 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 743720000466 putative ligand binding site [chemical binding]; other site 743720000467 NAD binding site [chemical binding]; other site 743720000468 catalytic site [active] 743720000469 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 743720000470 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 743720000471 substrate binding site [chemical binding]; other site 743720000472 active site 743720000473 catalytic residues [active] 743720000474 heterodimer interface [polypeptide binding]; other site 743720000475 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 743720000476 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 743720000477 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720000478 catalytic residue [active] 743720000479 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 743720000480 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 743720000481 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720000482 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720000483 dimerization interface [polypeptide binding]; other site 743720000484 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 743720000485 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 743720000486 dimer interface [polypeptide binding]; other site 743720000487 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 743720000488 active site 743720000489 metal binding site [ion binding]; metal-binding site 743720000490 glutathione binding site [chemical binding]; other site 743720000491 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 743720000492 active site 743720000493 metal binding site [ion binding]; metal-binding site 743720000494 homotetramer interface [polypeptide binding]; other site 743720000495 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 743720000496 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 743720000497 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720000498 active site 743720000499 phosphorylation site [posttranslational modification] 743720000500 intermolecular recognition site; other site 743720000501 dimerization interface [polypeptide binding]; other site 743720000502 CheB methylesterase; Region: CheB_methylest; pfam01339 743720000503 CheD chemotactic sensory transduction; Region: CheD; cl00810 743720000504 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 743720000505 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 743720000506 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 743720000507 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 743720000508 putative CheA interaction surface; other site 743720000509 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 743720000510 HAMP domain; Region: HAMP; pfam00672 743720000511 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720000512 dimer interface [polypeptide binding]; other site 743720000513 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 743720000514 putative CheW interface [polypeptide binding]; other site 743720000515 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 743720000516 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 743720000517 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 743720000518 putative binding surface; other site 743720000519 active site 743720000520 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 743720000521 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720000522 ATP binding site [chemical binding]; other site 743720000523 Mg2+ binding site [ion binding]; other site 743720000524 G-X-G motif; other site 743720000525 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 743720000526 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 743720000527 anti sigma factor interaction site; other site 743720000528 regulatory phosphorylation site [posttranslational modification]; other site 743720000529 Response regulator receiver domain; Region: Response_reg; pfam00072 743720000530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720000531 active site 743720000532 phosphorylation site [posttranslational modification] 743720000533 intermolecular recognition site; other site 743720000534 dimerization interface [polypeptide binding]; other site 743720000535 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720000536 dimer interface [polypeptide binding]; other site 743720000537 putative CheW interface [polypeptide binding]; other site 743720000538 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 743720000539 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720000540 active site 743720000541 phosphorylation site [posttranslational modification] 743720000542 intermolecular recognition site; other site 743720000543 dimerization interface [polypeptide binding]; other site 743720000544 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 743720000545 DNA binding residues [nucleotide binding] 743720000546 dimerization interface [polypeptide binding]; other site 743720000547 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 743720000548 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 743720000549 putative RNA binding site [nucleotide binding]; other site 743720000550 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720000551 S-adenosylmethionine binding site [chemical binding]; other site 743720000552 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 743720000553 intracellular protease, PfpI family; Region: PfpI; TIGR01382 743720000554 proposed catalytic triad [active] 743720000555 conserved cys residue [active] 743720000556 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 743720000557 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 743720000558 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 743720000559 DNA binding site [nucleotide binding] 743720000560 catalytic residue [active] 743720000561 H2TH interface [polypeptide binding]; other site 743720000562 putative catalytic residues [active] 743720000563 turnover-facilitating residue; other site 743720000564 intercalation triad [nucleotide binding]; other site 743720000565 8OG recognition residue [nucleotide binding]; other site 743720000566 putative reading head residues; other site 743720000567 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 743720000568 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 743720000569 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 743720000570 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 743720000571 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 743720000572 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 743720000573 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 743720000574 active site 743720000575 (T/H)XGH motif; other site 743720000576 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 743720000577 NAD(P) binding site [chemical binding]; other site 743720000578 catalytic residues [active] 743720000579 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 743720000580 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 743720000581 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720000582 S-adenosylmethionine binding site [chemical binding]; other site 743720000583 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 743720000584 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 743720000585 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 743720000586 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 743720000587 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 743720000588 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 743720000589 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 743720000590 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 743720000591 P loop; other site 743720000592 GTP binding site [chemical binding]; other site 743720000593 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 743720000594 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743720000595 Walker A/P-loop; other site 743720000596 ATP binding site [chemical binding]; other site 743720000597 Q-loop/lid; other site 743720000598 ABC transporter signature motif; other site 743720000599 Walker B; other site 743720000600 D-loop; other site 743720000601 H-loop/switch region; other site 743720000602 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 743720000603 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 743720000604 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 743720000605 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743720000606 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743720000607 DNA binding residues [nucleotide binding] 743720000608 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 743720000609 Transglycosylase; Region: Transgly; cl17702 743720000610 Protein of unknown function (DUF423); Region: DUF423; pfam04241 743720000611 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 743720000612 thiS-thiF/thiG interaction site; other site 743720000613 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 743720000614 ThiS interaction site; other site 743720000615 putative active site [active] 743720000616 tetramer interface [polypeptide binding]; other site 743720000617 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720000618 S-adenosylmethionine binding site [chemical binding]; other site 743720000619 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 743720000620 EamA-like transporter family; Region: EamA; pfam00892 743720000621 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 743720000622 putative active site [active] 743720000623 putative catalytic site [active] 743720000624 putative DNA binding site [nucleotide binding]; other site 743720000625 putative phosphate binding site [ion binding]; other site 743720000626 metal binding site A [ion binding]; metal-binding site 743720000627 putative AP binding site [nucleotide binding]; other site 743720000628 putative metal binding site B [ion binding]; other site 743720000629 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 743720000630 active site 743720000631 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 743720000632 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 743720000633 PBP superfamily domain; Region: PBP_like_2; cl17296 743720000634 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 743720000635 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720000636 ABC-ATPase subunit interface; other site 743720000637 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 743720000638 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 743720000639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720000640 dimer interface [polypeptide binding]; other site 743720000641 conserved gate region; other site 743720000642 putative PBP binding loops; other site 743720000643 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 743720000644 ABC-ATPase subunit interface; other site 743720000645 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 743720000646 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 743720000647 Walker A/P-loop; other site 743720000648 ATP binding site [chemical binding]; other site 743720000649 Q-loop/lid; other site 743720000650 ABC transporter signature motif; other site 743720000651 Walker B; other site 743720000652 D-loop; other site 743720000653 H-loop/switch region; other site 743720000654 transcriptional regulator PhoU; Provisional; Region: PRK11115 743720000655 PhoU domain; Region: PhoU; pfam01895 743720000656 PhoU domain; Region: PhoU; pfam01895 743720000657 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 743720000658 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720000659 active site 743720000660 phosphorylation site [posttranslational modification] 743720000661 intermolecular recognition site; other site 743720000662 dimerization interface [polypeptide binding]; other site 743720000663 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765 743720000664 DNA photolyase; Region: DNA_photolyase; pfam00875 743720000665 MarC family integral membrane protein; Region: MarC; cl00919 743720000666 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 743720000667 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 743720000668 amidase catalytic site [active] 743720000669 Zn binding residues [ion binding]; other site 743720000670 substrate binding site [chemical binding]; other site 743720000671 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 743720000672 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720000673 dimerization interface [polypeptide binding]; other site 743720000674 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 743720000675 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720000676 putative active site [active] 743720000677 heme pocket [chemical binding]; other site 743720000678 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720000679 dimer interface [polypeptide binding]; other site 743720000680 phosphorylation site [posttranslational modification] 743720000681 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720000682 ATP binding site [chemical binding]; other site 743720000683 Mg2+ binding site [ion binding]; other site 743720000684 G-X-G motif; other site 743720000685 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 743720000686 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720000687 active site 743720000688 phosphorylation site [posttranslational modification] 743720000689 intermolecular recognition site; other site 743720000690 dimerization interface [polypeptide binding]; other site 743720000691 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720000692 Walker A motif; other site 743720000693 ATP binding site [chemical binding]; other site 743720000694 Walker B motif; other site 743720000695 arginine finger; other site 743720000696 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 743720000697 BON domain; Region: BON; pfam04972 743720000698 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 743720000699 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 743720000700 BON domain; Region: BON; pfam04972 743720000701 BON domain; Region: BON; pfam04972 743720000702 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 743720000703 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816 743720000704 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 743720000705 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 743720000706 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 743720000707 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 743720000708 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720000709 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 743720000710 dimerization interface [polypeptide binding]; other site 743720000711 substrate binding pocket [chemical binding]; other site 743720000712 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 743720000713 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 743720000714 FAD binding site [chemical binding]; other site 743720000715 substrate binding pocket [chemical binding]; other site 743720000716 catalytic base [active] 743720000717 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 743720000718 CoA-transferase family III; Region: CoA_transf_3; pfam02515 743720000719 NnrS protein; Region: NnrS; pfam05940 743720000720 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 743720000721 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 743720000722 heme-binding site [chemical binding]; other site 743720000723 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 743720000724 FAD binding pocket [chemical binding]; other site 743720000725 FAD binding motif [chemical binding]; other site 743720000726 phosphate binding motif [ion binding]; other site 743720000727 beta-alpha-beta structure motif; other site 743720000728 NAD binding pocket [chemical binding]; other site 743720000729 Heme binding pocket [chemical binding]; other site 743720000730 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 743720000731 GAF domain; Region: GAF; pfam01590 743720000732 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720000733 Walker A motif; other site 743720000734 ATP binding site [chemical binding]; other site 743720000735 Walker B motif; other site 743720000736 arginine finger; other site 743720000737 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 743720000738 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 743720000739 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 743720000740 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 743720000741 tetramerization interface [polypeptide binding]; other site 743720000742 NAD(P) binding site [chemical binding]; other site 743720000743 catalytic residues [active] 743720000744 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 743720000745 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 743720000746 inhibitor-cofactor binding pocket; inhibition site 743720000747 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720000748 catalytic residue [active] 743720000749 Response regulator receiver domain; Region: Response_reg; pfam00072 743720000750 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720000751 active site 743720000752 phosphorylation site [posttranslational modification] 743720000753 intermolecular recognition site; other site 743720000754 dimerization interface [polypeptide binding]; other site 743720000755 HDOD domain; Region: HDOD; pfam08668 743720000756 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 743720000757 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 743720000758 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720000759 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720000760 dimer interface [polypeptide binding]; other site 743720000761 putative CheW interface [polypeptide binding]; other site 743720000762 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 743720000763 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 743720000764 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 743720000765 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 743720000766 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 743720000767 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 743720000768 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720000769 substrate binding pocket [chemical binding]; other site 743720000770 membrane-bound complex binding site; other site 743720000771 hinge residues; other site 743720000772 ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG4525 743720000773 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 743720000774 Walker A/P-loop; other site 743720000775 ATP binding site [chemical binding]; other site 743720000776 Q-loop/lid; other site 743720000777 ABC transporter signature motif; other site 743720000778 Walker B; other site 743720000779 D-loop; other site 743720000780 H-loop/switch region; other site 743720000781 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 743720000782 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720000783 dimer interface [polypeptide binding]; other site 743720000784 conserved gate region; other site 743720000785 putative PBP binding loops; other site 743720000786 ABC-ATPase subunit interface; other site 743720000787 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 743720000788 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 743720000789 Cache domain; Region: Cache_1; pfam02743 743720000790 HAMP domain; Region: HAMP; pfam00672 743720000791 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 743720000792 Dodecin; Region: Dodecin; pfam07311 743720000793 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 743720000794 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 743720000795 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 743720000796 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 743720000797 Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023 743720000798 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 743720000799 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 743720000800 Eukaryotic phosphomannomutase; Region: PMM; cl17107 743720000801 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743720000802 motif II; other site 743720000803 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 743720000804 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 743720000805 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 743720000806 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 743720000807 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 743720000808 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 743720000809 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720000810 Walker A motif; other site 743720000811 ATP binding site [chemical binding]; other site 743720000812 Walker B motif; other site 743720000813 arginine finger; other site 743720000814 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720000815 Walker A motif; other site 743720000816 ATP binding site [chemical binding]; other site 743720000817 Walker B motif; other site 743720000818 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 743720000819 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 743720000820 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 743720000821 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 743720000822 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 743720000823 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 743720000824 ImpE protein; Region: ImpE; pfam07024 743720000825 Protein of unknown function (DUF796); Region: DUF796; pfam05638 743720000826 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 743720000827 Protein of unknown function (DUF877); Region: DUF877; pfam05943 743720000828 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 743720000829 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 743720000830 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 743720000831 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 743720000832 phosphopeptide binding site; other site 743720000833 type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352 743720000834 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 743720000835 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 743720000836 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 743720000837 hypothetical protein; Provisional; Region: PRK07033 743720000838 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 743720000839 ligand binding site [chemical binding]; other site 743720000840 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 743720000841 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 743720000842 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 743720000843 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 743720000844 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 743720000845 Protein phosphatase 2C; Region: PP2C; pfam00481 743720000846 active site 743720000847 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 743720000848 Catalytic domain of Protein Kinases; Region: PKc; cd00180 743720000849 active site 743720000850 ATP binding site [chemical binding]; other site 743720000851 substrate binding site [chemical binding]; other site 743720000852 activation loop (A-loop); other site 743720000853 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 743720000854 metal ion-dependent adhesion site (MIDAS); other site 743720000855 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 743720000856 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743720000857 Walker A/P-loop; other site 743720000858 ATP binding site [chemical binding]; other site 743720000859 Q-loop/lid; other site 743720000860 ABC transporter signature motif; other site 743720000861 Walker B; other site 743720000862 D-loop; other site 743720000863 H-loop/switch region; other site 743720000864 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 743720000865 metabolite-proton symporter; Region: 2A0106; TIGR00883 743720000866 Cytochrome c553 [Energy production and conversion]; Region: COG2863 743720000867 Cytochrome c; Region: Cytochrom_C; cl11414 743720000868 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 743720000869 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 743720000870 catalytic residues [active] 743720000871 hinge region; other site 743720000872 alpha helical domain; other site 743720000873 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 743720000874 putative catalytic site [active] 743720000875 putative metal binding site [ion binding]; other site 743720000876 putative phosphate binding site [ion binding]; other site 743720000877 putative catalytic site [active] 743720000878 putative phosphate binding site [ion binding]; other site 743720000879 putative metal binding site [ion binding]; other site 743720000880 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743720000881 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720000882 metal binding site [ion binding]; metal-binding site 743720000883 active site 743720000884 I-site; other site 743720000885 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 743720000886 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 743720000887 Peptidase family M23; Region: Peptidase_M23; pfam01551 743720000888 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 743720000889 putative metal binding site [ion binding]; other site 743720000890 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 743720000891 Domain of unknown function DUF21; Region: DUF21; pfam01595 743720000892 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 743720000893 Transporter associated domain; Region: CorC_HlyC; smart01091 743720000894 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 743720000895 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 743720000896 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720000897 putative active site [active] 743720000898 heme pocket [chemical binding]; other site 743720000899 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720000900 dimer interface [polypeptide binding]; other site 743720000901 phosphorylation site [posttranslational modification] 743720000902 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720000903 ATP binding site [chemical binding]; other site 743720000904 Mg2+ binding site [ion binding]; other site 743720000905 G-X-G motif; other site 743720000906 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 743720000907 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720000908 active site 743720000909 phosphorylation site [posttranslational modification] 743720000910 intermolecular recognition site; other site 743720000911 dimerization interface [polypeptide binding]; other site 743720000912 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743720000913 DNA binding site [nucleotide binding] 743720000914 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 743720000915 UbiA prenyltransferase family; Region: UbiA; pfam01040 743720000916 Chorismate lyase; Region: Chor_lyase; cl01230 743720000917 Rubredoxin [Energy production and conversion]; Region: COG1773 743720000918 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 743720000919 iron binding site [ion binding]; other site 743720000920 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 743720000921 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743720000922 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 743720000923 IHF dimer interface [polypeptide binding]; other site 743720000924 IHF - DNA interface [nucleotide binding]; other site 743720000925 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 743720000926 putative deacylase active site [active] 743720000927 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 743720000928 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 743720000929 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 743720000930 generic binding surface II; other site 743720000931 ssDNA binding site; other site 743720000932 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743720000933 ATP binding site [chemical binding]; other site 743720000934 putative Mg++ binding site [ion binding]; other site 743720000935 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743720000936 nucleotide binding region [chemical binding]; other site 743720000937 ATP-binding site [chemical binding]; other site 743720000938 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 743720000939 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720000940 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 743720000941 dimerization interface [polypeptide binding]; other site 743720000942 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 743720000943 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 743720000944 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 743720000945 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 743720000946 tonB-system energizer ExbB; Region: exbB; TIGR02797 743720000947 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 743720000948 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 743720000949 putative NAD(P) binding site [chemical binding]; other site 743720000950 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 743720000951 homotrimer interaction site [polypeptide binding]; other site 743720000952 putative active site [active] 743720000953 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 743720000954 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 743720000955 Zn2+ binding site [ion binding]; other site 743720000956 Mg2+ binding site [ion binding]; other site 743720000957 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 743720000958 synthetase active site [active] 743720000959 NTP binding site [chemical binding]; other site 743720000960 metal binding site [ion binding]; metal-binding site 743720000961 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 743720000962 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 743720000963 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 743720000964 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 743720000965 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 743720000966 catalytic site [active] 743720000967 G-X2-G-X-G-K; other site 743720000968 hypothetical protein; Provisional; Region: PRK11820 743720000969 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 743720000970 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 743720000971 ribonuclease PH; Reviewed; Region: rph; PRK00173 743720000972 Ribonuclease PH; Region: RNase_PH_bact; cd11362 743720000973 hexamer interface [polypeptide binding]; other site 743720000974 active site 743720000975 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 743720000976 Protein of unknown function (DUF3392); Region: DUF3392; pfam11872 743720000977 HemN family oxidoreductase; Provisional; Region: PRK05660 743720000978 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743720000979 FeS/SAM binding site; other site 743720000980 HemN C-terminal domain; Region: HemN_C; pfam06969 743720000981 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 743720000982 active site 743720000983 dimerization interface [polypeptide binding]; other site 743720000984 Domain of unknown function (DUF4426); Region: DUF4426; pfam14467 743720000985 Methyltransferase domain; Region: Methyltransf_31; pfam13847 743720000986 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720000987 S-adenosylmethionine binding site [chemical binding]; other site 743720000988 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 743720000989 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 743720000990 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 743720000991 G1 box; other site 743720000992 GTP/Mg2+ binding site [chemical binding]; other site 743720000993 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 743720000994 G2 box; other site 743720000995 Switch I region; other site 743720000996 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 743720000997 G3 box; other site 743720000998 Switch II region; other site 743720000999 GTP/Mg2+ binding site [chemical binding]; other site 743720001000 G4 box; other site 743720001001 G5 box; other site 743720001002 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 743720001003 YGGT family; Region: YGGT; pfam02325 743720001004 YGGT family; Region: YGGT; pfam02325 743720001005 pyrroline-5-carboxylate reductase; Region: PLN02688 743720001006 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 743720001007 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 743720001008 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 743720001009 catalytic residue [active] 743720001010 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 743720001011 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 743720001012 Walker A motif; other site 743720001013 ATP binding site [chemical binding]; other site 743720001014 Walker B motif; other site 743720001015 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 743720001016 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 743720001017 Walker A motif; other site 743720001018 ATP binding site [chemical binding]; other site 743720001019 Walker B motif; other site 743720001020 Domain of unknown function (DUF4130; Region: DUF4130; cl14836 743720001021 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 743720001022 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743720001023 FeS/SAM binding site; other site 743720001024 TM2 domain; Region: TM2; cl00984 743720001025 dihydroorotase; Validated; Region: pyrC; PRK09357 743720001026 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 743720001027 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 743720001028 active site 743720001029 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 743720001030 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 743720001031 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 743720001032 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 743720001033 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 743720001034 active site 743720001035 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 743720001036 hypothetical protein; Validated; Region: PRK00228 743720001037 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 743720001038 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 743720001039 glutathione synthetase; Provisional; Region: PRK05246 743720001040 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 743720001041 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 743720001042 Response regulator receiver domain; Region: Response_reg; pfam00072 743720001043 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720001044 active site 743720001045 phosphorylation site [posttranslational modification] 743720001046 intermolecular recognition site; other site 743720001047 dimerization interface [polypeptide binding]; other site 743720001048 Response regulator receiver domain; Region: Response_reg; pfam00072 743720001049 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720001050 active site 743720001051 phosphorylation site [posttranslational modification] 743720001052 intermolecular recognition site; other site 743720001053 dimerization interface [polypeptide binding]; other site 743720001054 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 743720001055 putative CheA interaction surface; other site 743720001056 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 743720001057 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720001058 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720001059 dimer interface [polypeptide binding]; other site 743720001060 putative CheW interface [polypeptide binding]; other site 743720001061 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 743720001062 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 743720001063 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 743720001064 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 743720001065 putative binding surface; other site 743720001066 active site 743720001067 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 743720001068 putative binding surface; other site 743720001069 active site 743720001070 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 743720001071 putative binding surface; other site 743720001072 active site 743720001073 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 743720001074 putative binding surface; other site 743720001075 active site 743720001076 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 743720001077 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 743720001078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720001079 ATP binding site [chemical binding]; other site 743720001080 Mg2+ binding site [ion binding]; other site 743720001081 G-X-G motif; other site 743720001082 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 743720001083 Response regulator receiver domain; Region: Response_reg; pfam00072 743720001084 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720001085 active site 743720001086 phosphorylation site [posttranslational modification] 743720001087 intermolecular recognition site; other site 743720001088 dimerization interface [polypeptide binding]; other site 743720001089 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 743720001090 CheB methylesterase; Region: CheB_methylest; pfam01339 743720001091 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 743720001092 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 743720001093 Ferritin-like domain; Region: Ferritin; pfam00210 743720001094 dinuclear metal binding motif [ion binding]; other site 743720001095 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 743720001096 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 743720001097 RNA methyltransferase, RsmE family; Region: TIGR00046 743720001098 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK07030 743720001099 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 743720001100 inhibitor-cofactor binding pocket; inhibition site 743720001101 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720001102 catalytic residue [active] 743720001103 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 743720001104 hypothetical protein; Provisional; Region: PRK03757 743720001105 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 743720001106 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 743720001107 ATP binding site [chemical binding]; other site 743720001108 Mg++ binding site [ion binding]; other site 743720001109 motif III; other site 743720001110 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743720001111 nucleotide binding region [chemical binding]; other site 743720001112 ATP-binding site [chemical binding]; other site 743720001113 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 743720001114 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 743720001115 FAD binding pocket [chemical binding]; other site 743720001116 FAD binding motif [chemical binding]; other site 743720001117 phosphate binding motif [ion binding]; other site 743720001118 NAD binding pocket [chemical binding]; other site 743720001119 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 743720001120 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 743720001121 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 743720001122 FAD binding site [chemical binding]; other site 743720001123 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 743720001124 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 743720001125 homotetramer interface [polypeptide binding]; other site 743720001126 ligand binding site [chemical binding]; other site 743720001127 catalytic site [active] 743720001128 NAD binding site [chemical binding]; other site 743720001129 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 743720001130 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 743720001131 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 743720001132 nucleotide binding pocket [chemical binding]; other site 743720001133 K-X-D-G motif; other site 743720001134 catalytic site [active] 743720001135 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 743720001136 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 743720001137 S-adenosylmethionine synthetase; Validated; Region: PRK05250 743720001138 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 743720001139 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 743720001140 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 743720001141 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 743720001142 putative DNA binding site [nucleotide binding]; other site 743720001143 dimerization interface [polypeptide binding]; other site 743720001144 putative Zn2+ binding site [ion binding]; other site 743720001145 Methyltransferase domain; Region: Methyltransf_31; pfam13847 743720001146 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720001147 S-adenosylmethionine binding site [chemical binding]; other site 743720001148 transketolase; Reviewed; Region: PRK12753 743720001149 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 743720001150 TPP-binding site [chemical binding]; other site 743720001151 dimer interface [polypeptide binding]; other site 743720001152 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 743720001153 PYR/PP interface [polypeptide binding]; other site 743720001154 dimer interface [polypeptide binding]; other site 743720001155 TPP binding site [chemical binding]; other site 743720001156 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 743720001157 erythrose-4-phosphate dehydrogenase; Region: E4PD_g-proteo; TIGR01532 743720001158 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 743720001159 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 743720001160 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 743720001161 Phosphoglycerate kinase; Region: PGK; pfam00162 743720001162 substrate binding site [chemical binding]; other site 743720001163 hinge regions; other site 743720001164 ADP binding site [chemical binding]; other site 743720001165 catalytic site [active] 743720001166 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 743720001167 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 743720001168 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 743720001169 intersubunit interface [polypeptide binding]; other site 743720001170 active site 743720001171 zinc binding site [ion binding]; other site 743720001172 Na+ binding site [ion binding]; other site 743720001173 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 743720001174 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 743720001175 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 743720001176 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 743720001177 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 743720001178 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 743720001179 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 743720001180 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 743720001181 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 743720001182 C-terminal domain interface [polypeptide binding]; other site 743720001183 GSH binding site (G-site) [chemical binding]; other site 743720001184 dimer interface [polypeptide binding]; other site 743720001185 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 743720001186 N-terminal domain interface [polypeptide binding]; other site 743720001187 putative dimer interface [polypeptide binding]; other site 743720001188 active site 743720001189 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720001190 PAS fold; Region: PAS_3; pfam08447 743720001191 putative active site [active] 743720001192 heme pocket [chemical binding]; other site 743720001193 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720001194 PAS domain; Region: PAS_9; pfam13426 743720001195 putative active site [active] 743720001196 heme pocket [chemical binding]; other site 743720001197 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743720001198 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720001199 metal binding site [ion binding]; metal-binding site 743720001200 active site 743720001201 I-site; other site 743720001202 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743720001203 Fatty acid desaturase; Region: FA_desaturase; pfam00487 743720001204 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 743720001205 Di-iron ligands [ion binding]; other site 743720001206 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 743720001207 Transposase; Region: DDE_Tnp_ISL3; pfam01610 743720001208 PAS domain S-box; Region: sensory_box; TIGR00229 743720001209 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720001210 putative active site [active] 743720001211 heme pocket [chemical binding]; other site 743720001212 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 743720001213 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743720001214 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720001215 metal binding site [ion binding]; metal-binding site 743720001216 active site 743720001217 I-site; other site 743720001218 outer membrane porin, OprD family; Region: OprD; pfam03573 743720001219 agmatine deiminase; Provisional; Region: PRK13551 743720001220 agmatine deiminase; Region: agmatine_aguA; TIGR03380 743720001221 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 743720001222 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 743720001223 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 743720001224 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 743720001225 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 743720001226 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 743720001227 putative aminotransferase; Validated; Region: PRK07480 743720001228 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 743720001229 inhibitor-cofactor binding pocket; inhibition site 743720001230 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720001231 catalytic residue [active] 743720001232 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 743720001233 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 743720001234 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 743720001235 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 743720001236 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 743720001237 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743720001238 Walker A/P-loop; other site 743720001239 ATP binding site [chemical binding]; other site 743720001240 Q-loop/lid; other site 743720001241 ABC transporter signature motif; other site 743720001242 Walker B; other site 743720001243 D-loop; other site 743720001244 H-loop/switch region; other site 743720001245 TOBE domain; Region: TOBE_2; pfam08402 743720001246 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720001247 dimer interface [polypeptide binding]; other site 743720001248 conserved gate region; other site 743720001249 putative PBP binding loops; other site 743720001250 ABC-ATPase subunit interface; other site 743720001251 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 743720001252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720001253 dimer interface [polypeptide binding]; other site 743720001254 conserved gate region; other site 743720001255 putative PBP binding loops; other site 743720001256 ABC-ATPase subunit interface; other site 743720001257 BCCT family transporter; Region: BCCT; cl00569 743720001258 Membrane fusogenic activity; Region: BMFP; pfam04380 743720001259 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 743720001260 Nitrogen regulatory protein P-II; Region: P-II; smart00938 743720001261 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 743720001262 probable ammonium transporter, marine subtype; Region: marine_trans_1; TIGR03644 743720001263 Uncharacterized conserved protein [Function unknown]; Region: COG0432 743720001264 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 743720001265 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743720001266 motif II; other site 743720001267 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 743720001268 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 743720001269 active site 743720001270 Int/Topo IB signature motif; other site 743720001271 Protein of unknown function, DUF484; Region: DUF484; cl17449 743720001272 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 743720001273 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 743720001274 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 743720001275 diaminopimelate decarboxylase; Region: lysA; TIGR01048 743720001276 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 743720001277 active site 743720001278 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 743720001279 substrate binding site [chemical binding]; other site 743720001280 catalytic residues [active] 743720001281 dimer interface [polypeptide binding]; other site 743720001282 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627 743720001283 frataxin-like protein; Provisional; Region: cyaY; PRK00446 743720001284 putative iron binding site [ion binding]; other site 743720001285 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 743720001286 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 743720001287 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 743720001288 adenylate cyclase; Provisional; Region: cyaA; PRK09450 743720001289 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 743720001290 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 743720001291 TIGR02647 family protein; Region: DNA 743720001292 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720001293 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 743720001294 substrate binding pocket [chemical binding]; other site 743720001295 membrane-bound complex binding site; other site 743720001296 hinge residues; other site 743720001297 Transcriptional regulator [Transcription]; Region: IclR; COG1414 743720001298 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 743720001299 Bacterial transcriptional regulator; Region: IclR; pfam01614 743720001300 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 743720001301 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 743720001302 active site 743720001303 intersubunit interface [polypeptide binding]; other site 743720001304 catalytic residue [active] 743720001305 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 743720001306 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 743720001307 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 743720001308 C-terminal domain interface [polypeptide binding]; other site 743720001309 GSH binding site (G-site) [chemical binding]; other site 743720001310 dimer interface [polypeptide binding]; other site 743720001311 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 743720001312 N-terminal domain interface [polypeptide binding]; other site 743720001313 dimer interface [polypeptide binding]; other site 743720001314 substrate binding pocket (H-site) [chemical binding]; other site 743720001315 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720001316 Coenzyme A binding pocket [chemical binding]; other site 743720001317 argininosuccinate lyase; Provisional; Region: PRK00855 743720001318 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 743720001319 active sites [active] 743720001320 tetramer interface [polypeptide binding]; other site 743720001321 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 743720001322 Histidine kinase; Region: His_kinase; pfam06580 743720001323 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 743720001324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720001325 active site 743720001326 phosphorylation site [posttranslational modification] 743720001327 intermolecular recognition site; other site 743720001328 dimerization interface [polypeptide binding]; other site 743720001329 LytTr DNA-binding domain; Region: LytTR; pfam04397 743720001330 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 743720001331 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 743720001332 domain interfaces; other site 743720001333 active site 743720001334 uroporphyrinogen-III synthase; Validated; Region: PRK05752 743720001335 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 743720001336 active site 743720001337 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 743720001338 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 743720001339 HemY protein N-terminus; Region: HemY_N; pfam07219 743720001340 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ; Region: Rsd_AlgQ; pfam04353 743720001341 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597 743720001342 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597 743720001343 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 743720001344 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 743720001345 Bacterial transcriptional repressor; Region: TetR; pfam13972 743720001346 poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240 743720001347 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 743720001348 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 743720001349 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 743720001350 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 743720001351 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 743720001352 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720001353 Walker A motif; other site 743720001354 ATP binding site [chemical binding]; other site 743720001355 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 743720001356 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 743720001357 ATP-dependent protease subunit HslV; Provisional; Region: PRK05456 743720001358 active site 743720001359 Sporulation related domain; Region: SPOR; pfam05036 743720001360 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 743720001361 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 743720001362 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 743720001363 active site 743720001364 HIGH motif; other site 743720001365 KMSK motif region; other site 743720001366 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 743720001367 tRNA binding surface [nucleotide binding]; other site 743720001368 anticodon binding site; other site 743720001369 primosome assembly protein PriA; Validated; Region: PRK05580 743720001370 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743720001371 ATP binding site [chemical binding]; other site 743720001372 putative Mg++ binding site [ion binding]; other site 743720001373 helicase superfamily c-terminal domain; Region: HELICc; smart00490 743720001374 ATP-binding site [chemical binding]; other site 743720001375 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 743720001376 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 743720001377 Catalytic site; other site 743720001378 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 743720001379 Peptidase family M48; Region: Peptidase_M48; pfam01435 743720001380 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 743720001381 Malic enzyme, N-terminal domain; Region: malic; pfam00390 743720001382 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 743720001383 putative NAD(P) binding site [chemical binding]; other site 743720001384 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 743720001385 Transglycosylase; Region: Transgly; pfam00912 743720001386 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 743720001387 Competence protein A; Region: Competence_A; pfam11104 743720001388 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 743720001389 nucleotide binding site [chemical binding]; other site 743720001390 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 743720001391 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 743720001392 Tfp pilus assembly protein PilO [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilO; COG3167 743720001393 Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168 743720001394 Pilus assembly protein, PilP; Region: PilP; pfam04351 743720001395 AMIN domain; Region: AMIN; pfam11741 743720001396 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 743720001397 Secretin and TonB N terminus short domain; Region: STN; smart00965 743720001398 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 743720001399 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 743720001400 shikimate kinase; Reviewed; Region: aroK; PRK00131 743720001401 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 743720001402 ADP binding site [chemical binding]; other site 743720001403 magnesium binding site [ion binding]; other site 743720001404 putative shikimate binding site; other site 743720001405 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 743720001406 active site 743720001407 dimer interface [polypeptide binding]; other site 743720001408 metal binding site [ion binding]; metal-binding site 743720001409 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 743720001410 AAA ATPase domain; Region: AAA_16; pfam13191 743720001411 Walker A motif; other site 743720001412 ATP binding site [chemical binding]; other site 743720001413 Walker B motif; other site 743720001414 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 743720001415 Sporulation related domain; Region: SPOR; pfam05036 743720001416 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 743720001417 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 743720001418 active site 743720001419 dimer interface [polypeptide binding]; other site 743720001420 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 743720001421 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 743720001422 active site 743720001423 FMN binding site [chemical binding]; other site 743720001424 substrate binding site [chemical binding]; other site 743720001425 3Fe-4S cluster binding site [ion binding]; other site 743720001426 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 743720001427 domain interface; other site 743720001428 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 743720001429 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 743720001430 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 743720001431 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 743720001432 substrate binding site [chemical binding]; other site 743720001433 active site 743720001434 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 743720001435 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 743720001436 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK06816 743720001437 dimer interface [polypeptide binding]; other site 743720001438 active site 743720001439 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 743720001440 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 743720001441 active site 743720001442 Phosphopantetheine attachment site; Region: PP-binding; cl09936 743720001443 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 743720001444 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 743720001445 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 743720001446 Walker A/P-loop; other site 743720001447 ATP binding site [chemical binding]; other site 743720001448 Q-loop/lid; other site 743720001449 ABC transporter signature motif; other site 743720001450 Walker B; other site 743720001451 D-loop; other site 743720001452 H-loop/switch region; other site 743720001453 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 743720001454 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 743720001455 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 743720001456 dimer interface [polypeptide binding]; other site 743720001457 active site 743720001458 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720001459 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 743720001460 NAD(P) binding site [chemical binding]; other site 743720001461 active site 743720001462 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 743720001463 putative active site 1 [active] 743720001464 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 743720001465 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 743720001466 dimer interface [polypeptide binding]; other site 743720001467 active site 743720001468 Methyltransferase domain; Region: Methyltransf_23; pfam13489 743720001469 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720001470 S-adenosylmethionine binding site [chemical binding]; other site 743720001471 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 743720001472 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 743720001473 Predicted exporter [General function prediction only]; Region: COG4258 743720001474 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 743720001475 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 743720001476 active site 743720001477 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 743720001478 active sites [active] 743720001479 tetramer interface [polypeptide binding]; other site 743720001480 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 743720001481 putative acyl-acceptor binding pocket; other site 743720001482 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 743720001483 Ligand binding site; other site 743720001484 Putative Catalytic site; other site 743720001485 DXD motif; other site 743720001486 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 743720001487 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 743720001488 active site 743720001489 AMP binding site [chemical binding]; other site 743720001490 acyl-activating enzyme (AAE) consensus motif; other site 743720001491 CoA binding site [chemical binding]; other site 743720001492 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 743720001493 active site 2 [active] 743720001494 dimer interface [polypeptide binding]; other site 743720001495 active site 1 [active] 743720001496 Predicted membrane protein [Function unknown]; Region: COG4648 743720001497 acyl carrier protein; Provisional; Region: PRK05350 743720001498 Phosphopantetheine attachment site; Region: PP-binding; cl09936 743720001499 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 743720001500 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 743720001501 putative acyl-acceptor binding pocket; other site 743720001502 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 743720001503 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 743720001504 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 743720001505 P-loop; other site 743720001506 Magnesium ion binding site [ion binding]; other site 743720001507 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 743720001508 Magnesium ion binding site [ion binding]; other site 743720001509 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 743720001510 Ligand Binding Site [chemical binding]; other site 743720001511 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 743720001512 Ligand Binding Site [chemical binding]; other site 743720001513 thioredoxin 2; Provisional; Region: PRK10996 743720001514 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 743720001515 catalytic residues [active] 743720001516 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 743720001517 BCCT family transporter; Region: BCCT; pfam02028 743720001518 YcaO domain protein; Region: TIGR03549 743720001519 OsmC-like protein; Region: OsmC; pfam02566 743720001520 YcaO-like family; Region: YcaO; pfam02624 743720001521 Uncharacterized conserved protein [Function unknown]; Region: COG3791 743720001522 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 743720001523 aspartate racemase; Region: asp_race; TIGR00035 743720001524 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 743720001525 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 743720001526 Uncharacterized conserved protein [Function unknown]; Region: COG0397 743720001527 hypothetical protein; Validated; Region: PRK00029 743720001528 hypothetical protein; Provisional; Region: PRK11281 743720001529 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 743720001530 Mechanosensitive ion channel; Region: MS_channel; pfam00924 743720001531 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 743720001532 TrkA-C domain; Region: TrkA_C; pfam02080 743720001533 Transporter associated domain; Region: CorC_HlyC; smart01091 743720001534 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 743720001535 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 743720001536 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 743720001537 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 743720001538 catalytic residues [active] 743720001539 transcription termination factor Rho; Provisional; Region: rho; PRK09376 743720001540 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 743720001541 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 743720001542 RNA binding site [nucleotide binding]; other site 743720001543 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 743720001544 multimer interface [polypeptide binding]; other site 743720001545 Walker A motif; other site 743720001546 ATP binding site [chemical binding]; other site 743720001547 Walker B motif; other site 743720001548 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 743720001549 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 743720001550 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 743720001551 catalytic loop [active] 743720001552 iron binding site [ion binding]; other site 743720001553 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 743720001554 FAD binding pocket [chemical binding]; other site 743720001555 FAD binding motif [chemical binding]; other site 743720001556 phosphate binding motif [ion binding]; other site 743720001557 beta-alpha-beta structure motif; other site 743720001558 NAD binding pocket [chemical binding]; other site 743720001559 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 743720001560 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 743720001561 NAD(P) binding site [chemical binding]; other site 743720001562 flagellar basal body-associated protein FliL-like protein; Validated; Region: PRK05697 743720001563 Uncharacterized conserved protein [Function unknown]; Region: COG2947 743720001564 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 743720001565 Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division, chromosome partitioning]; Region: zapA; COG3027 743720001566 TIGR02449 family protein; Region: TIGR02449 743720001567 hypothetical protein; Reviewed; Region: PRK02166 743720001568 proline aminopeptidase P II; Provisional; Region: PRK10879 743720001569 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 743720001570 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 743720001571 active site 743720001572 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 743720001573 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 743720001574 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK05714 743720001575 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 743720001576 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 743720001577 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 743720001578 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 743720001579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720001580 dimer interface [polypeptide binding]; other site 743720001581 conserved gate region; other site 743720001582 putative PBP binding loops; other site 743720001583 ABC-ATPase subunit interface; other site 743720001584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 743720001585 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 743720001586 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 743720001587 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 743720001588 lipoyl attachment site [posttranslational modification]; other site 743720001589 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 743720001590 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720001591 dimerization interface [polypeptide binding]; other site 743720001592 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720001593 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720001594 dimer interface [polypeptide binding]; other site 743720001595 putative CheW interface [polypeptide binding]; other site 743720001596 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 743720001597 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 743720001598 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 743720001599 Walker A motif; other site 743720001600 ATP binding site [chemical binding]; other site 743720001601 Walker B motif; other site 743720001602 Uncharacterized conserved protein [Function unknown]; Region: COG2928 743720001603 Uncharacterized conserved protein [Function unknown]; Region: COG3025 743720001604 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 743720001605 putative active site [active] 743720001606 putative metal binding residues [ion binding]; other site 743720001607 signature motif; other site 743720001608 putative triphosphate binding site [ion binding]; other site 743720001609 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 743720001610 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 743720001611 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 743720001612 acetylornithine deacetylase; Provisional; Region: PRK05111 743720001613 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 743720001614 metal binding site [ion binding]; metal-binding site 743720001615 putative dimer interface [polypeptide binding]; other site 743720001616 N-acetylglutamate synthase; Validated; Region: PRK05279 743720001617 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 743720001618 putative feedback inhibition sensing region; other site 743720001619 putative nucleotide binding site [chemical binding]; other site 743720001620 putative substrate binding site [chemical binding]; other site 743720001621 N-acetylglutamate synthase and related acetyltransferases [Amino acid transport and metabolism]; Region: ArgA; COG1246 743720001622 Coenzyme A binding pocket [chemical binding]; other site 743720001623 glutamate carboxypeptidase; Reviewed; Region: PRK06133 743720001624 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 743720001625 metal binding site [ion binding]; metal-binding site 743720001626 dimer interface [polypeptide binding]; other site 743720001627 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 743720001628 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720001629 S-adenosylmethionine binding site [chemical binding]; other site 743720001630 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 743720001631 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 743720001632 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 743720001633 nucleotide binding site [chemical binding]; other site 743720001634 putative NEF/HSP70 interaction site [polypeptide binding]; other site 743720001635 SBD interface [polypeptide binding]; other site 743720001636 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 743720001637 HSP70 interaction site [polypeptide binding]; other site 743720001638 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 743720001639 HSP70 interaction site [polypeptide binding]; other site 743720001640 enterobactin exporter EntS; Provisional; Region: PRK10489 743720001641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720001642 putative substrate translocation pore; other site 743720001643 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 743720001644 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720001645 heme pocket [chemical binding]; other site 743720001646 putative active site [active] 743720001647 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720001648 dimer interface [polypeptide binding]; other site 743720001649 phosphorylation site [posttranslational modification] 743720001650 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720001651 ATP binding site [chemical binding]; other site 743720001652 Mg2+ binding site [ion binding]; other site 743720001653 G-X-G motif; other site 743720001654 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 743720001655 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720001656 active site 743720001657 phosphorylation site [posttranslational modification] 743720001658 intermolecular recognition site; other site 743720001659 dimerization interface [polypeptide binding]; other site 743720001660 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 743720001661 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720001662 active site 743720001663 phosphorylation site [posttranslational modification] 743720001664 intermolecular recognition site; other site 743720001665 dimerization interface [polypeptide binding]; other site 743720001666 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720001667 PAS fold; Region: PAS_3; pfam08447 743720001668 putative active site [active] 743720001669 heme pocket [chemical binding]; other site 743720001670 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720001671 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 743720001672 putative active site [active] 743720001673 heme pocket [chemical binding]; other site 743720001674 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720001675 ATP binding site [chemical binding]; other site 743720001676 G-X-G motif; other site 743720001677 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 743720001678 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720001679 active site 743720001680 intermolecular recognition site; other site 743720001681 dimerization interface [polypeptide binding]; other site 743720001682 Response regulator receiver domain; Region: Response_reg; pfam00072 743720001683 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720001684 active site 743720001685 phosphorylation site [posttranslational modification] 743720001686 intermolecular recognition site; other site 743720001687 dimerization interface [polypeptide binding]; other site 743720001688 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 743720001689 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 743720001690 putative active site [active] 743720001691 heme pocket [chemical binding]; other site 743720001692 GAF domain; Region: GAF; pfam01590 743720001693 Phytochrome region; Region: PHY; pfam00360 743720001694 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720001695 dimer interface [polypeptide binding]; other site 743720001696 phosphorylation site [posttranslational modification] 743720001697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720001698 ATP binding site [chemical binding]; other site 743720001699 G-X-G motif; other site 743720001700 SdiA-regulated; Region: SdiA-regulated; cd09971 743720001701 SdiA-regulated; Region: SdiA-regulated; pfam06977 743720001702 putative active site [active] 743720001703 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 743720001704 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 743720001705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720001706 S-adenosylmethionine binding site [chemical binding]; other site 743720001707 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 743720001708 homodimer interface [polypeptide binding]; other site 743720001709 chemical substrate binding site [chemical binding]; other site 743720001710 oligomer interface [polypeptide binding]; other site 743720001711 metal binding site [ion binding]; metal-binding site 743720001712 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 743720001713 active site 2 [active] 743720001714 active site 1 [active] 743720001715 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 743720001716 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720001717 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 743720001718 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720001719 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720001720 NAD(P) binding site [chemical binding]; other site 743720001721 active site 743720001722 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 743720001723 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 743720001724 dimer interface [polypeptide binding]; other site 743720001725 active site 743720001726 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 743720001727 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 743720001728 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720001729 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 743720001730 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 743720001731 DNA binding site [nucleotide binding] 743720001732 active site 743720001733 Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718 743720001734 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 743720001735 ATP binding site [chemical binding]; other site 743720001736 nitrite reductase subunit NirD; Provisional; Region: PRK14989 743720001737 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743720001738 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 743720001739 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 743720001740 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 743720001741 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 743720001742 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 743720001743 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 743720001744 Protein phosphatase 2C; Region: PP2C; pfam00481 743720001745 active site 743720001746 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 743720001747 Catalytic domain of Protein Kinases; Region: PKc; cd00180 743720001748 active site 743720001749 ATP binding site [chemical binding]; other site 743720001750 substrate binding site [chemical binding]; other site 743720001751 activation loop (A-loop); other site 743720001752 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 743720001753 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 743720001754 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 743720001755 HAMP domain; Region: HAMP; pfam00672 743720001756 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720001757 dimer interface [polypeptide binding]; other site 743720001758 putative CheW interface [polypeptide binding]; other site 743720001759 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 743720001760 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720001761 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 743720001762 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 743720001763 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720001764 DNA-binding site [nucleotide binding]; DNA binding site 743720001765 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743720001766 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720001767 homodimer interface [polypeptide binding]; other site 743720001768 catalytic residue [active] 743720001769 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 743720001770 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 743720001771 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 743720001772 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 743720001773 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 743720001774 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 743720001775 D-pathway; other site 743720001776 Putative ubiquinol binding site [chemical binding]; other site 743720001777 Low-spin heme (heme b) binding site [chemical binding]; other site 743720001778 Putative water exit pathway; other site 743720001779 Binuclear center (heme o3/CuB) [ion binding]; other site 743720001780 K-pathway; other site 743720001781 Putative proton exit pathway; other site 743720001782 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 743720001783 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743720001784 N-terminal plug; other site 743720001785 ligand-binding site [chemical binding]; other site 743720001786 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 743720001787 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720001788 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720001789 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 743720001790 putative effector binding pocket; other site 743720001791 dimerization interface [polypeptide binding]; other site 743720001792 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 743720001793 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 743720001794 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 743720001795 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720001796 dimer interface [polypeptide binding]; other site 743720001797 phosphorylation site [posttranslational modification] 743720001798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720001799 ATP binding site [chemical binding]; other site 743720001800 Mg2+ binding site [ion binding]; other site 743720001801 G-X-G motif; other site 743720001802 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 743720001803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720001804 active site 743720001805 phosphorylation site [posttranslational modification] 743720001806 intermolecular recognition site; other site 743720001807 dimerization interface [polypeptide binding]; other site 743720001808 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 743720001809 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 743720001810 Cytochrome c; Region: Cytochrom_C; pfam00034 743720001811 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 743720001812 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 743720001813 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 743720001814 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720001815 PAS domain; Region: PAS_9; pfam13426 743720001816 putative active site [active] 743720001817 heme pocket [chemical binding]; other site 743720001818 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720001819 PAS domain; Region: PAS_9; pfam13426 743720001820 putative active site [active] 743720001821 heme pocket [chemical binding]; other site 743720001822 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720001823 dimer interface [polypeptide binding]; other site 743720001824 putative CheW interface [polypeptide binding]; other site 743720001825 Protein of unknown function (DUF1654); Region: DUF1654; pfam07867 743720001826 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720001827 PAS domain; Region: PAS_9; pfam13426 743720001828 putative active site [active] 743720001829 heme pocket [chemical binding]; other site 743720001830 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720001831 ATP binding site [chemical binding]; other site 743720001832 Mg2+ binding site [ion binding]; other site 743720001833 G-X-G motif; other site 743720001834 Methyltransferase domain; Region: Methyltransf_32; pfam13679 743720001835 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 743720001836 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720001837 dimer interface [polypeptide binding]; other site 743720001838 conserved gate region; other site 743720001839 putative PBP binding loops; other site 743720001840 ABC-ATPase subunit interface; other site 743720001841 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 743720001842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720001843 dimer interface [polypeptide binding]; other site 743720001844 conserved gate region; other site 743720001845 putative PBP binding loops; other site 743720001846 ABC-ATPase subunit interface; other site 743720001847 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 743720001848 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720001849 substrate binding pocket [chemical binding]; other site 743720001850 membrane-bound complex binding site; other site 743720001851 hinge residues; other site 743720001852 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 743720001853 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 743720001854 Walker A/P-loop; other site 743720001855 ATP binding site [chemical binding]; other site 743720001856 Q-loop/lid; other site 743720001857 ABC transporter signature motif; other site 743720001858 Walker B; other site 743720001859 D-loop; other site 743720001860 H-loop/switch region; other site 743720001861 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 743720001862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720001863 active site 743720001864 phosphorylation site [posttranslational modification] 743720001865 intermolecular recognition site; other site 743720001866 dimerization interface [polypeptide binding]; other site 743720001867 CHASE3 domain; Region: CHASE3; pfam05227 743720001868 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 743720001869 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 743720001870 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720001871 dimer interface [polypeptide binding]; other site 743720001872 phosphorylation site [posttranslational modification] 743720001873 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720001874 ATP binding site [chemical binding]; other site 743720001875 Mg2+ binding site [ion binding]; other site 743720001876 G-X-G motif; other site 743720001877 Response regulator receiver domain; Region: Response_reg; pfam00072 743720001878 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720001879 active site 743720001880 phosphorylation site [posttranslational modification] 743720001881 intermolecular recognition site; other site 743720001882 dimerization interface [polypeptide binding]; other site 743720001883 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 743720001884 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720001885 active site 743720001886 phosphorylation site [posttranslational modification] 743720001887 intermolecular recognition site; other site 743720001888 Response regulator receiver domain; Region: Response_reg; pfam00072 743720001889 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720001890 active site 743720001891 phosphorylation site [posttranslational modification] 743720001892 intermolecular recognition site; other site 743720001893 dimerization interface [polypeptide binding]; other site 743720001894 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 743720001895 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 743720001896 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 743720001897 CheB methylesterase; Region: CheB_methylest; pfam01339 743720001898 Response regulator receiver domain; Region: Response_reg; pfam00072 743720001899 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720001900 active site 743720001901 phosphorylation site [posttranslational modification] 743720001902 intermolecular recognition site; other site 743720001903 dimerization interface [polypeptide binding]; other site 743720001904 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743720001905 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720001906 dimer interface [polypeptide binding]; other site 743720001907 phosphorylation site [posttranslational modification] 743720001908 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720001909 ATP binding site [chemical binding]; other site 743720001910 Mg2+ binding site [ion binding]; other site 743720001911 G-X-G motif; other site 743720001912 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720001913 active site 743720001914 phosphorylation site [posttranslational modification] 743720001915 intermolecular recognition site; other site 743720001916 dimerization interface [polypeptide binding]; other site 743720001917 anthranilate synthase component I; Provisional; Region: PRK13565 743720001918 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 743720001919 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 743720001920 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 743720001921 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 743720001922 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 743720001923 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 743720001924 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 743720001925 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 743720001926 carboxyltransferase (CT) interaction site; other site 743720001927 biotinylation site [posttranslational modification]; other site 743720001928 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 743720001929 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 743720001930 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 743720001931 hypothetical protein; Provisional; Region: PRK05463 743720001932 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 743720001933 putative active site [active] 743720001934 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 743720001935 Transcriptional regulators [Transcription]; Region: GntR; COG1802 743720001936 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720001937 DNA-binding site [nucleotide binding]; DNA binding site 743720001938 FCD domain; Region: FCD; pfam07729 743720001939 Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112 743720001940 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 743720001941 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 743720001942 non-specific DNA binding site [nucleotide binding]; other site 743720001943 salt bridge; other site 743720001944 sequence-specific DNA binding site [nucleotide binding]; other site 743720001945 Predicted transcriptional regulator [Transcription]; Region: COG2932 743720001946 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 743720001947 Catalytic site [active] 743720001948 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 743720001949 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 743720001950 catalytic residue [active] 743720001951 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 743720001952 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 743720001953 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720001954 Coenzyme A binding pocket [chemical binding]; other site 743720001955 AAA domain; Region: AAA_17; cl17253 743720001956 phosphoglycolate phosphatase; Provisional; Region: PRK13223 743720001957 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 743720001958 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 743720001959 glutamine binding [chemical binding]; other site 743720001960 catalytic triad [active] 743720001961 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 743720001962 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 743720001963 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 743720001964 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 743720001965 active site 743720001966 ribulose/triose binding site [chemical binding]; other site 743720001967 phosphate binding site [ion binding]; other site 743720001968 substrate (anthranilate) binding pocket [chemical binding]; other site 743720001969 product (indole) binding pocket [chemical binding]; other site 743720001970 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05742 743720001971 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 743720001972 dimerization interface [polypeptide binding]; other site 743720001973 active site 743720001974 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793 743720001975 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 743720001976 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 743720001977 amidase catalytic site [active] 743720001978 Zn binding residues [ion binding]; other site 743720001979 substrate binding site [chemical binding]; other site 743720001980 Membrane protein required for beta-lactamase induction [Defense mechanisms]; Region: AmpE; cl17896 743720001981 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 743720001982 active site 743720001983 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 743720001984 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 743720001985 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 743720001986 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 743720001987 DNA binding site [nucleotide binding] 743720001988 domain linker motif; other site 743720001989 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 743720001990 dimerization interface [polypeptide binding]; other site 743720001991 ligand binding site [chemical binding]; other site 743720001992 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 743720001993 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 743720001994 active site 743720001995 phosphorylation site [posttranslational modification] 743720001996 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 743720001997 dimerization domain swap beta strand [polypeptide binding]; other site 743720001998 regulatory protein interface [polypeptide binding]; other site 743720001999 active site 743720002000 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 743720002001 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 743720002002 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 743720002003 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 743720002004 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 743720002005 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 743720002006 putative substrate binding site [chemical binding]; other site 743720002007 putative ATP binding site [chemical binding]; other site 743720002008 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 743720002009 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 743720002010 active site 743720002011 P-loop; other site 743720002012 phosphorylation site [posttranslational modification] 743720002013 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 743720002014 active site 743720002015 P-loop; other site 743720002016 phosphorylation site [posttranslational modification] 743720002017 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 743720002018 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 743720002019 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 743720002020 ligand binding site [chemical binding]; other site 743720002021 flexible hinge region; other site 743720002022 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 743720002023 putative switch regulator; other site 743720002024 non-specific DNA interactions [nucleotide binding]; other site 743720002025 DNA binding site [nucleotide binding] 743720002026 sequence specific DNA binding site [nucleotide binding]; other site 743720002027 putative cAMP binding site [chemical binding]; other site 743720002028 OsmC-like protein; Region: OsmC; cl00767 743720002029 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 743720002030 diiron binding motif [ion binding]; other site 743720002031 Ycf46; Provisional; Region: ycf46; CHL00195 743720002032 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720002033 Walker A motif; other site 743720002034 ATP binding site [chemical binding]; other site 743720002035 Walker B motif; other site 743720002036 arginine finger; other site 743720002037 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 743720002038 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720002039 NAD(P) binding site [chemical binding]; other site 743720002040 active site 743720002041 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 743720002042 Protein of unknown function (DUF805); Region: DUF805; pfam05656 743720002043 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 743720002044 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 743720002045 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 743720002046 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 743720002047 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 743720002048 putative peptidase; Provisional; Region: PRK11649 743720002049 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 743720002050 Peptidase family M23; Region: Peptidase_M23; pfam01551 743720002051 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 743720002052 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 743720002053 active site 743720002054 HIGH motif; other site 743720002055 dimer interface [polypeptide binding]; other site 743720002056 KMSKS motif; other site 743720002057 pantothenate kinase; Reviewed; Region: PRK13322 743720002058 Sporulation related domain; Region: SPOR; pfam05036 743720002059 elongation factor Tu; Reviewed; Region: PRK00049 743720002060 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 743720002061 G1 box; other site 743720002062 GEF interaction site [polypeptide binding]; other site 743720002063 GTP/Mg2+ binding site [chemical binding]; other site 743720002064 Switch I region; other site 743720002065 G2 box; other site 743720002066 G3 box; other site 743720002067 Switch II region; other site 743720002068 G4 box; other site 743720002069 G5 box; other site 743720002070 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 743720002071 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 743720002072 Antibiotic Binding Site [chemical binding]; other site 743720002073 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 743720002074 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 743720002075 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 743720002076 putative homodimer interface [polypeptide binding]; other site 743720002077 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 743720002078 heterodimer interface [polypeptide binding]; other site 743720002079 homodimer interface [polypeptide binding]; other site 743720002080 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 743720002081 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 743720002082 23S rRNA interface [nucleotide binding]; other site 743720002083 L7/L12 interface [polypeptide binding]; other site 743720002084 putative thiostrepton binding site; other site 743720002085 L25 interface [polypeptide binding]; other site 743720002086 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 743720002087 mRNA/rRNA interface [nucleotide binding]; other site 743720002088 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 743720002089 23S rRNA interface [nucleotide binding]; other site 743720002090 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 743720002091 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 743720002092 core dimer interface [polypeptide binding]; other site 743720002093 peripheral dimer interface [polypeptide binding]; other site 743720002094 L10 interface [polypeptide binding]; other site 743720002095 L11 interface [polypeptide binding]; other site 743720002096 putative EF-Tu interaction site [polypeptide binding]; other site 743720002097 putative EF-G interaction site [polypeptide binding]; other site 743720002098 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 743720002099 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 743720002100 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 743720002101 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 743720002102 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 743720002103 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 743720002104 RPB3 interaction site [polypeptide binding]; other site 743720002105 RPB1 interaction site [polypeptide binding]; other site 743720002106 RPB11 interaction site [polypeptide binding]; other site 743720002107 RPB10 interaction site [polypeptide binding]; other site 743720002108 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 743720002109 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 743720002110 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 743720002111 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 743720002112 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 743720002113 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 743720002114 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 743720002115 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 743720002116 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 743720002117 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 743720002118 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 743720002119 DNA binding site [nucleotide binding] 743720002120 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 743720002121 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 743720002122 S17 interaction site [polypeptide binding]; other site 743720002123 S8 interaction site; other site 743720002124 16S rRNA interaction site [nucleotide binding]; other site 743720002125 streptomycin interaction site [chemical binding]; other site 743720002126 23S rRNA interaction site [nucleotide binding]; other site 743720002127 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 743720002128 30S ribosomal protein S7; Validated; Region: PRK05302 743720002129 elongation factor G; Reviewed; Region: PRK00007 743720002130 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 743720002131 G1 box; other site 743720002132 putative GEF interaction site [polypeptide binding]; other site 743720002133 GTP/Mg2+ binding site [chemical binding]; other site 743720002134 Switch I region; other site 743720002135 G2 box; other site 743720002136 G3 box; other site 743720002137 Switch II region; other site 743720002138 G4 box; other site 743720002139 G5 box; other site 743720002140 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 743720002141 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 743720002142 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 743720002143 elongation factor Tu; Reviewed; Region: PRK00049 743720002144 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 743720002145 G1 box; other site 743720002146 GEF interaction site [polypeptide binding]; other site 743720002147 GTP/Mg2+ binding site [chemical binding]; other site 743720002148 Switch I region; other site 743720002149 G2 box; other site 743720002150 G3 box; other site 743720002151 Switch II region; other site 743720002152 G4 box; other site 743720002153 G5 box; other site 743720002154 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 743720002155 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 743720002156 Antibiotic Binding Site [chemical binding]; other site 743720002157 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 743720002158 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 743720002159 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 743720002160 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 743720002161 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 743720002162 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 743720002163 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 743720002164 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 743720002165 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 743720002166 protein-rRNA interface [nucleotide binding]; other site 743720002167 putative translocon binding site; other site 743720002168 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 743720002169 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 743720002170 G-X-X-G motif; other site 743720002171 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 743720002172 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 743720002173 23S rRNA interface [nucleotide binding]; other site 743720002174 5S rRNA interface [nucleotide binding]; other site 743720002175 putative antibiotic binding site [chemical binding]; other site 743720002176 L25 interface [polypeptide binding]; other site 743720002177 L27 interface [polypeptide binding]; other site 743720002178 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 743720002179 23S rRNA interface [nucleotide binding]; other site 743720002180 putative translocon interaction site; other site 743720002181 signal recognition particle (SRP54) interaction site; other site 743720002182 L23 interface [polypeptide binding]; other site 743720002183 trigger factor interaction site; other site 743720002184 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 743720002185 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 743720002186 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 743720002187 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 743720002188 RNA binding site [nucleotide binding]; other site 743720002189 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 743720002190 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 743720002191 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 743720002192 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 743720002193 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 743720002194 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 743720002195 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 743720002196 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 743720002197 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 743720002198 5S rRNA interface [nucleotide binding]; other site 743720002199 23S rRNA interface [nucleotide binding]; other site 743720002200 L5 interface [polypeptide binding]; other site 743720002201 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 743720002202 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 743720002203 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 743720002204 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 743720002205 23S rRNA binding site [nucleotide binding]; other site 743720002206 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 743720002207 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 743720002208 SecY translocase; Region: SecY; pfam00344 743720002209 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 743720002210 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 743720002211 30S ribosomal protein S13; Region: bact_S13; TIGR03631 743720002212 30S ribosomal protein S11; Validated; Region: PRK05309 743720002213 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 743720002214 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 743720002215 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 743720002216 RNA binding surface [nucleotide binding]; other site 743720002217 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 743720002218 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 743720002219 alphaNTD homodimer interface [polypeptide binding]; other site 743720002220 alphaNTD - beta interaction site [polypeptide binding]; other site 743720002221 alphaNTD - beta' interaction site [polypeptide binding]; other site 743720002222 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 743720002223 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 743720002224 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 743720002225 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 743720002226 dimer interface [polypeptide binding]; other site 743720002227 active site 743720002228 heme binding site [chemical binding]; other site 743720002229 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 743720002230 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 743720002231 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 743720002232 heme binding site [chemical binding]; other site 743720002233 ferroxidase pore; other site 743720002234 ferroxidase diiron center [ion binding]; other site 743720002235 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 743720002236 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 743720002237 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 743720002238 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 743720002239 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720002240 Major Facilitator Superfamily; Region: MFS_1; pfam07690 743720002241 putative substrate translocation pore; other site 743720002242 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 743720002243 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 743720002244 dimer interface [polypeptide binding]; other site 743720002245 ssDNA binding site [nucleotide binding]; other site 743720002246 tetramer (dimer of dimers) interface [polypeptide binding]; other site 743720002247 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 743720002248 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720002249 NAD(P) binding site [chemical binding]; other site 743720002250 active site 743720002251 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720002252 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 743720002253 NAD(P) binding site [chemical binding]; other site 743720002254 active site 743720002255 OmpW family; Region: OmpW; cl17427 743720002256 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 743720002257 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 743720002258 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 743720002259 FtsX-like permease family; Region: FtsX; pfam02687 743720002260 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 743720002261 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 743720002262 Walker A/P-loop; other site 743720002263 ATP binding site [chemical binding]; other site 743720002264 Q-loop/lid; other site 743720002265 ABC transporter signature motif; other site 743720002266 Walker B; other site 743720002267 D-loop; other site 743720002268 H-loop/switch region; other site 743720002269 Protein of unknown function (DUF2796); Region: DUF2796; pfam10986 743720002270 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 743720002271 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 743720002272 Predicted methyltransferase [General function prediction only]; Region: COG3897 743720002273 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 743720002274 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 743720002275 ATP cone domain; Region: ATP-cone; pfam03477 743720002276 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 743720002277 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 743720002278 catalytic motif [active] 743720002279 Zn binding site [ion binding]; other site 743720002280 RibD C-terminal domain; Region: RibD_C; cl17279 743720002281 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-II; Region: Lumazine_synthase-II; cd09208 743720002282 active site 743720002283 homopentamer interface [polypeptide binding]; other site 743720002284 dimer interface [polypeptide binding]; other site 743720002285 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 743720002286 Lumazine binding domain; Region: Lum_binding; pfam00677 743720002287 Lumazine binding domain; Region: Lum_binding; pfam00677 743720002288 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 743720002289 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 743720002290 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 743720002291 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 743720002292 homopentamer interface [polypeptide binding]; other site 743720002293 active site 743720002294 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 743720002295 putative RNA binding site [nucleotide binding]; other site 743720002296 thiamine monophosphate kinase; Provisional; Region: PRK05731 743720002297 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 743720002298 ATP binding site [chemical binding]; other site 743720002299 dimerization interface [polypeptide binding]; other site 743720002300 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 743720002301 tetramer interfaces [polypeptide binding]; other site 743720002302 binuclear metal-binding site [ion binding]; other site 743720002303 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 743720002304 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 743720002305 substrate binding pocket [chemical binding]; other site 743720002306 membrane-bound complex binding site; other site 743720002307 hinge residues; other site 743720002308 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 743720002309 catalytic motif [active] 743720002310 Catalytic residue [active] 743720002311 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 743720002312 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 743720002313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720002314 dimer interface [polypeptide binding]; other site 743720002315 conserved gate region; other site 743720002316 putative PBP binding loops; other site 743720002317 ABC-ATPase subunit interface; other site 743720002318 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 743720002319 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 743720002320 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720002321 dimer interface [polypeptide binding]; other site 743720002322 conserved gate region; other site 743720002323 ABC-ATPase subunit interface; other site 743720002324 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 743720002325 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 743720002326 Walker A/P-loop; other site 743720002327 ATP binding site [chemical binding]; other site 743720002328 Q-loop/lid; other site 743720002329 ABC transporter signature motif; other site 743720002330 Walker B; other site 743720002331 D-loop; other site 743720002332 H-loop/switch region; other site 743720002333 FOG: CBS domain [General function prediction only]; Region: COG0517 743720002334 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 743720002335 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 743720002336 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 743720002337 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 743720002338 NAD(P) binding site [chemical binding]; other site 743720002339 catalytic residues [active] 743720002340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720002341 Major Facilitator Superfamily; Region: MFS_1; pfam07690 743720002342 putative substrate translocation pore; other site 743720002343 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 743720002344 PLD-like domain; Region: PLDc_2; pfam13091 743720002345 putative active site [active] 743720002346 catalytic site [active] 743720002347 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 743720002348 PLD-like domain; Region: PLDc_2; pfam13091 743720002349 putative active site [active] 743720002350 catalytic site [active] 743720002351 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 743720002352 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720002353 DNA-binding site [nucleotide binding]; DNA binding site 743720002354 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743720002355 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720002356 homodimer interface [polypeptide binding]; other site 743720002357 catalytic residue [active] 743720002358 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 743720002359 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 743720002360 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 743720002361 Flagellin N-methylase; Region: FliB; pfam03692 743720002362 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 743720002363 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 743720002364 putative DNA binding site [nucleotide binding]; other site 743720002365 putative Zn2+ binding site [ion binding]; other site 743720002366 AsnC family; Region: AsnC_trans_reg; pfam01037 743720002367 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 743720002368 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 743720002369 hydroxyglutarate oxidase; Provisional; Region: PRK11728 743720002370 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 743720002371 homotrimer interaction site [polypeptide binding]; other site 743720002372 putative active site [active] 743720002373 alanine racemase; Reviewed; Region: dadX; PRK03646 743720002374 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 743720002375 active site 743720002376 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 743720002377 substrate binding site [chemical binding]; other site 743720002378 catalytic residues [active] 743720002379 dimer interface [polypeptide binding]; other site 743720002380 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 743720002381 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 743720002382 non-specific DNA binding site [nucleotide binding]; other site 743720002383 salt bridge; other site 743720002384 sequence-specific DNA binding site [nucleotide binding]; other site 743720002385 Cupin domain; Region: Cupin_2; pfam07883 743720002386 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 743720002387 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 743720002388 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 743720002389 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 743720002390 active site 743720002391 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 743720002392 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 743720002393 Part of AAA domain; Region: AAA_19; pfam13245 743720002394 Family description; Region: UvrD_C_2; pfam13538 743720002395 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720002396 metal binding site [ion binding]; metal-binding site 743720002397 active site 743720002398 I-site; other site 743720002399 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743720002400 multidrug efflux protein NorA; Provisional; Region: PRK00187 743720002401 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 743720002402 cation binding site [ion binding]; other site 743720002403 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 743720002404 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720002405 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720002406 dimerization interface [polypeptide binding]; other site 743720002407 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720002408 dimerization interface [polypeptide binding]; other site 743720002409 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720002410 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720002411 dimer interface [polypeptide binding]; other site 743720002412 putative CheW interface [polypeptide binding]; other site 743720002413 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 743720002414 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 743720002415 dimer interface [polypeptide binding]; other site 743720002416 active site 743720002417 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 743720002418 catalytic residues [active] 743720002419 substrate binding site [chemical binding]; other site 743720002420 AAA domain; Region: AAA_32; pfam13654 743720002421 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 743720002422 hypothetical protein; Provisional; Region: PRK05208 743720002423 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 743720002424 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 743720002425 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 743720002426 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 743720002427 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 743720002428 substrate binding pocket [chemical binding]; other site 743720002429 chain length determination region; other site 743720002430 substrate-Mg2+ binding site; other site 743720002431 catalytic residues [active] 743720002432 aspartate-rich region 1; other site 743720002433 active site lid residues [active] 743720002434 aspartate-rich region 2; other site 743720002435 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 743720002436 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 743720002437 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 743720002438 GTPase CgtA; Reviewed; Region: obgE; PRK12298 743720002439 GTP1/OBG; Region: GTP1_OBG; pfam01018 743720002440 Obg GTPase; Region: Obg; cd01898 743720002441 G1 box; other site 743720002442 GTP/Mg2+ binding site [chemical binding]; other site 743720002443 Switch I region; other site 743720002444 G2 box; other site 743720002445 G3 box; other site 743720002446 Switch II region; other site 743720002447 G4 box; other site 743720002448 G5 box; other site 743720002449 gamma-glutamyl kinase; Provisional; Region: PRK05429 743720002450 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 743720002451 nucleotide binding site [chemical binding]; other site 743720002452 homotetrameric interface [polypeptide binding]; other site 743720002453 putative phosphate binding site [ion binding]; other site 743720002454 putative allosteric binding site; other site 743720002455 PUA domain; Region: PUA; pfam01472 743720002456 CreA protein; Region: CreA; pfam05981 743720002457 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 743720002458 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720002459 dimerization interface [polypeptide binding]; other site 743720002460 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720002461 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720002462 dimer interface [polypeptide binding]; other site 743720002463 putative CheW interface [polypeptide binding]; other site 743720002464 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 743720002465 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 743720002466 MviN-like protein; Region: MVIN; pfam03023 743720002467 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 743720002468 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 743720002469 active site 743720002470 Riboflavin kinase; Region: Flavokinase; smart00904 743720002471 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 743720002472 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 743720002473 active site 743720002474 HIGH motif; other site 743720002475 nucleotide binding site [chemical binding]; other site 743720002476 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 743720002477 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 743720002478 active site 743720002479 KMSKS motif; other site 743720002480 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 743720002481 tRNA binding surface [nucleotide binding]; other site 743720002482 anticodon binding site; other site 743720002483 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 743720002484 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 743720002485 lipoprotein signal peptidase; Provisional; Region: PRK14787 743720002486 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 743720002487 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 743720002488 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 743720002489 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 743720002490 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 743720002491 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 743720002492 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 743720002493 dimer interface [polypeptide binding]; other site 743720002494 substrate binding site [chemical binding]; other site 743720002495 metal binding sites [ion binding]; metal-binding site 743720002496 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 743720002497 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 743720002498 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720002499 Coenzyme A binding pocket [chemical binding]; other site 743720002500 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 743720002501 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 743720002502 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 743720002503 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 743720002504 aromatic acid decarboxylase; Validated; Region: PRK05920 743720002505 Flavoprotein; Region: Flavoprotein; pfam02441 743720002506 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 743720002507 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 743720002508 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 743720002509 putative ligand binding site [chemical binding]; other site 743720002510 NAD binding site [chemical binding]; other site 743720002511 catalytic site [active] 743720002512 Uncharacterized conserved protein [Function unknown]; Region: COG1739 743720002513 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 743720002514 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 743720002515 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 743720002516 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 743720002517 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 743720002518 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 743720002519 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 743720002520 active site 743720002521 catalytic tetrad [active] 743720002522 transcription termination factor Rho; Provisional; Region: PRK12678 743720002523 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 743720002524 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720002525 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720002526 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 743720002527 dimerization interface [polypeptide binding]; other site 743720002528 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 743720002529 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 743720002530 inhibitor-cofactor binding pocket; inhibition site 743720002531 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720002532 catalytic residue [active] 743720002533 Cupin domain; Region: Cupin_2; cl17218 743720002534 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 743720002535 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 743720002536 tetrameric interface [polypeptide binding]; other site 743720002537 NAD binding site [chemical binding]; other site 743720002538 catalytic residues [active] 743720002539 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 743720002540 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 743720002541 putative metal binding site [ion binding]; other site 743720002542 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 743720002543 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 743720002544 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 743720002545 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 743720002546 dimerization interface [polypeptide binding]; other site 743720002547 ligand binding site [chemical binding]; other site 743720002548 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 743720002549 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 743720002550 TM-ABC transporter signature motif; other site 743720002551 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 743720002552 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 743720002553 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 743720002554 TM-ABC transporter signature motif; other site 743720002555 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 743720002556 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 743720002557 Walker A/P-loop; other site 743720002558 ATP binding site [chemical binding]; other site 743720002559 Q-loop/lid; other site 743720002560 ABC transporter signature motif; other site 743720002561 Walker B; other site 743720002562 D-loop; other site 743720002563 H-loop/switch region; other site 743720002564 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 743720002565 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 743720002566 Walker A/P-loop; other site 743720002567 ATP binding site [chemical binding]; other site 743720002568 Q-loop/lid; other site 743720002569 ABC transporter signature motif; other site 743720002570 Walker B; other site 743720002571 D-loop; other site 743720002572 H-loop/switch region; other site 743720002573 azurin; Region: azurin; TIGR02695 743720002574 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 743720002575 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 743720002576 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 743720002577 Protein of unknown function (DUF1043); Region: DUF1043; cl11473 743720002578 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 743720002579 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 743720002580 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284 743720002581 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 743720002582 active site 743720002583 HIGH motif; other site 743720002584 dimer interface [polypeptide binding]; other site 743720002585 KMSKS motif; other site 743720002586 Predicted ATPase [General function prediction only]; Region: COG1485 743720002587 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 743720002588 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 743720002589 conserved cys residue [active] 743720002590 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720002591 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720002592 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 743720002593 Active_site [active] 743720002594 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 743720002595 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 743720002596 active site 743720002597 catalytic tetrad [active] 743720002598 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 743720002599 23S rRNA interface [nucleotide binding]; other site 743720002600 L3 interface [polypeptide binding]; other site 743720002601 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 743720002602 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 743720002603 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 743720002604 [2Fe-2S] cluster binding site [ion binding]; other site 743720002605 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 743720002606 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 743720002607 Qi binding site; other site 743720002608 intrachain domain interface; other site 743720002609 interchain domain interface [polypeptide binding]; other site 743720002610 heme bH binding site [chemical binding]; other site 743720002611 heme bL binding site [chemical binding]; other site 743720002612 Qo binding site; other site 743720002613 interchain domain interface [polypeptide binding]; other site 743720002614 intrachain domain interface; other site 743720002615 Qi binding site; other site 743720002616 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 743720002617 Qo binding site; other site 743720002618 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 743720002619 stringent starvation protein A; Provisional; Region: sspA; PRK09481 743720002620 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 743720002621 C-terminal domain interface [polypeptide binding]; other site 743720002622 putative GSH binding site (G-site) [chemical binding]; other site 743720002623 dimer interface [polypeptide binding]; other site 743720002624 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 743720002625 dimer interface [polypeptide binding]; other site 743720002626 N-terminal domain interface [polypeptide binding]; other site 743720002627 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 743720002628 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 743720002629 BON domain; Region: BON; pfam04972 743720002630 CsbD-like; Region: CsbD; cl17424 743720002631 hypothetical protein; Provisional; Region: PRK06110 743720002632 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 743720002633 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 743720002634 catalytic residue [active] 743720002635 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 743720002636 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720002637 DNA-binding site [nucleotide binding]; DNA binding site 743720002638 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743720002639 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720002640 homodimer interface [polypeptide binding]; other site 743720002641 catalytic residue [active] 743720002642 AMP nucleosidase; Provisional; Region: PRK08292 743720002643 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 743720002644 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 743720002645 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 743720002646 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 743720002647 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 743720002648 Zn2+ binding site [ion binding]; other site 743720002649 Mg2+ binding site [ion binding]; other site 743720002650 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720002651 Major Facilitator Superfamily; Region: MFS_1; pfam07690 743720002652 putative substrate translocation pore; other site 743720002653 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 743720002654 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 743720002655 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 743720002656 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 743720002657 Walker A/P-loop; other site 743720002658 ATP binding site [chemical binding]; other site 743720002659 Q-loop/lid; other site 743720002660 ABC transporter signature motif; other site 743720002661 Walker B; other site 743720002662 D-loop; other site 743720002663 H-loop/switch region; other site 743720002664 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 743720002665 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 743720002666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720002667 dimer interface [polypeptide binding]; other site 743720002668 conserved gate region; other site 743720002669 putative PBP binding loops; other site 743720002670 ABC-ATPase subunit interface; other site 743720002671 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 743720002672 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720002673 substrate binding pocket [chemical binding]; other site 743720002674 membrane-bound complex binding site; other site 743720002675 hinge residues; other site 743720002676 Transcriptional regulators [Transcription]; Region: GntR; COG1802 743720002677 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720002678 DNA-binding site [nucleotide binding]; DNA binding site 743720002679 FCD domain; Region: FCD; pfam07729 743720002680 amidase; Provisional; Region: PRK07869 743720002681 Amidase; Region: Amidase; cl11426 743720002682 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720002683 Major Facilitator Superfamily; Region: MFS_1; pfam07690 743720002684 putative substrate translocation pore; other site 743720002685 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 743720002686 Helix-turn-helix domain; Region: HTH_18; pfam12833 743720002687 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720002688 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 743720002689 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720002690 putative substrate translocation pore; other site 743720002691 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 743720002692 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720002693 dimer interface [polypeptide binding]; other site 743720002694 phosphorylation site [posttranslational modification] 743720002695 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720002696 ATP binding site [chemical binding]; other site 743720002697 Mg2+ binding site [ion binding]; other site 743720002698 G-X-G motif; other site 743720002699 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 743720002700 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720002701 active site 743720002702 phosphorylation site [posttranslational modification] 743720002703 intermolecular recognition site; other site 743720002704 dimerization interface [polypeptide binding]; other site 743720002705 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743720002706 DNA binding site [nucleotide binding] 743720002707 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720002708 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 743720002709 Family of unknown function (DUF633); Region: DUF633; pfam04816 743720002710 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 743720002711 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 743720002712 Walker A/P-loop; other site 743720002713 ATP binding site [chemical binding]; other site 743720002714 Q-loop/lid; other site 743720002715 ABC transporter signature motif; other site 743720002716 Walker B; other site 743720002717 D-loop; other site 743720002718 H-loop/switch region; other site 743720002719 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 743720002720 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743720002721 Walker A/P-loop; other site 743720002722 ATP binding site [chemical binding]; other site 743720002723 Q-loop/lid; other site 743720002724 ABC transporter signature motif; other site 743720002725 Walker B; other site 743720002726 D-loop; other site 743720002727 H-loop/switch region; other site 743720002728 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 743720002729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 743720002730 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 743720002731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720002732 dimer interface [polypeptide binding]; other site 743720002733 conserved gate region; other site 743720002734 putative PBP binding loops; other site 743720002735 ABC-ATPase subunit interface; other site 743720002736 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 743720002737 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 743720002738 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 743720002739 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720002740 dimerization interface [polypeptide binding]; other site 743720002741 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720002742 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720002743 dimer interface [polypeptide binding]; other site 743720002744 putative CheW interface [polypeptide binding]; other site 743720002745 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 743720002746 putative active site [active] 743720002747 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 743720002748 Nuclease-related domain; Region: NERD; pfam08378 743720002749 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 743720002750 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 743720002751 Acyltransferase family; Region: Acyl_transf_3; pfam01757 743720002752 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 743720002753 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 743720002754 Cupin; Region: Cupin_6; pfam12852 743720002755 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720002756 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 743720002757 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720002758 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 743720002759 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 743720002760 conserved cys residue [active] 743720002761 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720002762 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 743720002763 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720002764 NAD(P) binding site [chemical binding]; other site 743720002765 active site 743720002766 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720002767 NAD(P) binding site [chemical binding]; other site 743720002768 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 743720002769 active site 743720002770 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 743720002771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720002772 Cation efflux family; Region: Cation_efflux; cl00316 743720002773 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 743720002774 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 743720002775 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743720002776 ATP binding site [chemical binding]; other site 743720002777 putative Mg++ binding site [ion binding]; other site 743720002778 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743720002779 nucleotide binding region [chemical binding]; other site 743720002780 ATP-binding site [chemical binding]; other site 743720002781 Helicase associated domain (HA2); Region: HA2; pfam04408 743720002782 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 743720002783 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 743720002784 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 743720002785 active site 743720002786 tetramer interface [polypeptide binding]; other site 743720002787 Transcriptional regulators [Transcription]; Region: PurR; COG1609 743720002788 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 743720002789 DNA binding site [nucleotide binding] 743720002790 domain linker motif; other site 743720002791 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 743720002792 putative dimerization interface [polypeptide binding]; other site 743720002793 putative ligand binding site [chemical binding]; other site 743720002794 Uncharacterized protein family (UPF0259); Region: UPF0259; cl11642 743720002795 Uncharacterized conserved protein [Function unknown]; Region: COG1432 743720002796 LabA_like proteins; Region: LabA_like/DUF88; cl10034 743720002797 putative metal binding site [ion binding]; other site 743720002798 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 743720002799 active site 743720002800 catalytic site [active] 743720002801 substrate binding site [chemical binding]; other site 743720002802 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 743720002803 DEAD-like helicases superfamily; Region: DEXDc; smart00487 743720002804 ATP binding site [chemical binding]; other site 743720002805 Mg++ binding site [ion binding]; other site 743720002806 motif III; other site 743720002807 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743720002808 nucleotide binding region [chemical binding]; other site 743720002809 ATP-binding site [chemical binding]; other site 743720002810 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 743720002811 active site 743720002812 metal binding site [ion binding]; metal-binding site 743720002813 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 743720002814 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 743720002815 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 743720002816 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 743720002817 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 743720002818 putative active site [active] 743720002819 Zn binding site [ion binding]; other site 743720002820 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 743720002821 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 743720002822 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 743720002823 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 743720002824 active site 743720002825 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 743720002826 catalytic triad [active] 743720002827 dimer interface [polypeptide binding]; other site 743720002828 Spore Coat Protein U domain; Region: SCPU; pfam05229 743720002829 Uncharacterized secreted protein [Function unknown]; Region: COG5430 743720002830 Spore Coat Protein U domain; Region: SCPU; pfam05229 743720002831 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 743720002832 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 743720002833 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 743720002834 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 743720002835 PapC C-terminal domain; Region: PapC_C; pfam13953 743720002836 Spore Coat Protein U domain; Region: SCPU; cl02253 743720002837 Spore Coat Protein U domain; Region: SCPU; pfam05229 743720002838 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 743720002839 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743720002840 active site 743720002841 motif I; other site 743720002842 motif II; other site 743720002843 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 743720002844 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 743720002845 DNA binding residues [nucleotide binding] 743720002846 dimer interface [polypeptide binding]; other site 743720002847 copper binding site [ion binding]; other site 743720002848 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 743720002849 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 743720002850 metal-binding site [ion binding] 743720002851 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 743720002852 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 743720002853 metal-binding site [ion binding] 743720002854 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 743720002855 Soluble P-type ATPase [General function prediction only]; Region: COG4087 743720002856 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 743720002857 metal-binding site [ion binding] 743720002858 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 743720002859 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 743720002860 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 743720002861 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720002862 putative substrate translocation pore; other site 743720002863 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 743720002864 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 743720002865 ligand binding site [chemical binding]; other site 743720002866 flexible hinge region; other site 743720002867 TfoX C-terminal domain; Region: TfoX_C; pfam04994 743720002868 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 743720002869 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 743720002870 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 743720002871 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 743720002872 Predicted kinase [General function prediction only]; Region: COG0645 743720002873 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 743720002874 active site 743720002875 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 743720002876 Transglycosylase; Region: Transgly; pfam00912 743720002877 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 743720002878 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743720002879 Tetratricopeptide repeat; Region: TPR_16; pfam13432 743720002880 TPR motif; other site 743720002881 binding surface 743720002882 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 743720002883 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 743720002884 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466 743720002885 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 743720002886 PYR/PP interface [polypeptide binding]; other site 743720002887 dimer interface [polypeptide binding]; other site 743720002888 TPP binding site [chemical binding]; other site 743720002889 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 743720002890 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 743720002891 TPP-binding site [chemical binding]; other site 743720002892 dimer interface [polypeptide binding]; other site 743720002893 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 743720002894 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 743720002895 putative valine binding site [chemical binding]; other site 743720002896 dimer interface [polypeptide binding]; other site 743720002897 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 743720002898 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720002899 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 743720002900 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 743720002901 putative dimerization interface [polypeptide binding]; other site 743720002902 ketol-acid reductoisomerase; Provisional; Region: PRK05479 743720002903 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 743720002904 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 743720002905 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 743720002906 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 743720002907 TMAO/DMSO reductase; Reviewed; Region: PRK05363 743720002908 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 743720002909 Moco binding site; other site 743720002910 metal coordination site [ion binding]; other site 743720002911 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 743720002912 Paraquat-inducible protein A; Region: PqiA; pfam04403 743720002913 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 743720002914 Paraquat-inducible protein A; Region: PqiA; pfam04403 743720002915 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 743720002916 mce related protein; Region: MCE; pfam02470 743720002917 mce related protein; Region: MCE; pfam02470 743720002918 mce related protein; Region: MCE; pfam02470 743720002919 mce related protein; Region: MCE; pfam02470 743720002920 mce related protein; Region: MCE; pfam02470 743720002921 mce related protein; Region: MCE; pfam02470 743720002922 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 743720002923 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 743720002924 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 743720002925 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 743720002926 dimer interface [polypeptide binding]; other site 743720002927 active site 743720002928 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 743720002929 catalytic residues [active] 743720002930 substrate binding site [chemical binding]; other site 743720002931 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 743720002932 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 743720002933 NAD(P) binding pocket [chemical binding]; other site 743720002934 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 743720002935 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 743720002936 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720002937 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720002938 dimer interface [polypeptide binding]; other site 743720002939 putative CheW interface [polypeptide binding]; other site 743720002940 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 743720002941 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 743720002942 Citrate transporter; Region: CitMHS; pfam03600 743720002943 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 743720002944 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720002945 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720002946 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720002947 dimerization interface [polypeptide binding]; other site 743720002948 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 743720002949 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 743720002950 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 743720002951 active site clefts [active] 743720002952 zinc binding site [ion binding]; other site 743720002953 dimer interface [polypeptide binding]; other site 743720002954 EamA-like transporter family; Region: EamA; pfam00892 743720002955 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 743720002956 EamA-like transporter family; Region: EamA; pfam00892 743720002957 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 743720002958 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 743720002959 intersubunit interface [polypeptide binding]; other site 743720002960 RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when...; Region: RhoGAP; cl02570 743720002961 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 743720002962 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 743720002963 PhnA protein; Region: PhnA; pfam03831 743720002964 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 743720002965 homotrimer interaction site [polypeptide binding]; other site 743720002966 putative active site [active] 743720002967 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 743720002968 Water Stress and Hypersensitive response; Region: WHy; smart00769 743720002969 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 743720002970 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 743720002971 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 743720002972 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 743720002973 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 743720002974 HlyD family secretion protein; Region: HlyD_3; pfam13437 743720002975 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 743720002976 Protein export membrane protein; Region: SecD_SecF; cl14618 743720002977 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 743720002978 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 743720002979 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 743720002980 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 743720002981 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 743720002982 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 743720002983 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 743720002984 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 743720002985 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 743720002986 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 743720002987 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 743720002988 active site 743720002989 Transmembrane secretion effector; Region: MFS_3; pfam05977 743720002990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720002991 putative substrate translocation pore; other site 743720002992 Isochorismatase family; Region: Isochorismatase; pfam00857 743720002993 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 743720002994 catalytic triad [active] 743720002995 dimer interface [polypeptide binding]; other site 743720002996 conserved cis-peptide bond; other site 743720002997 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720002998 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720002999 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 743720003000 putative substrate binding pocket [chemical binding]; other site 743720003001 putative dimerization interface [polypeptide binding]; other site 743720003002 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 743720003003 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 743720003004 conserved cys residue [active] 743720003005 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720003006 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720003007 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 743720003008 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743720003009 DNA binding site [nucleotide binding] 743720003010 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720003011 Predicted ATPase [General function prediction only]; Region: COG3903 743720003012 Walker A motif; other site 743720003013 ATP binding site [chemical binding]; other site 743720003014 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720003015 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 743720003016 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720003017 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 743720003018 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720003019 active site 743720003020 phosphorylation site [posttranslational modification] 743720003021 intermolecular recognition site; other site 743720003022 dimerization interface [polypeptide binding]; other site 743720003023 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 743720003024 DNA binding residues [nucleotide binding] 743720003025 dimerization interface [polypeptide binding]; other site 743720003026 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 743720003027 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 743720003028 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 743720003029 Histidine kinase; Region: HisKA_3; pfam07730 743720003030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720003031 ATP binding site [chemical binding]; other site 743720003032 Mg2+ binding site [ion binding]; other site 743720003033 G-X-G motif; other site 743720003034 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 743720003035 Fic/DOC family; Region: Fic; cl00960 743720003036 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720003037 PAS fold; Region: PAS_3; pfam08447 743720003038 putative active site [active] 743720003039 heme pocket [chemical binding]; other site 743720003040 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720003041 PAS fold; Region: PAS_3; pfam08447 743720003042 putative active site [active] 743720003043 heme pocket [chemical binding]; other site 743720003044 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743720003045 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720003046 metal binding site [ion binding]; metal-binding site 743720003047 active site 743720003048 I-site; other site 743720003049 GTP-binding protein YchF; Reviewed; Region: PRK09601 743720003050 YchF GTPase; Region: YchF; cd01900 743720003051 G1 box; other site 743720003052 GTP/Mg2+ binding site [chemical binding]; other site 743720003053 Switch I region; other site 743720003054 G2 box; other site 743720003055 Switch II region; other site 743720003056 G3 box; other site 743720003057 G4 box; other site 743720003058 G5 box; other site 743720003059 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 743720003060 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 743720003061 putative active site [active] 743720003062 catalytic residue [active] 743720003063 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 743720003064 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 743720003065 5S rRNA interface [nucleotide binding]; other site 743720003066 CTC domain interface [polypeptide binding]; other site 743720003067 L16 interface [polypeptide binding]; other site 743720003068 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 743720003069 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 743720003070 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 743720003071 active site 743720003072 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 743720003073 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 743720003074 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 743720003075 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 743720003076 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 743720003077 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743720003078 TPR motif; other site 743720003079 binding surface 743720003080 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743720003081 binding surface 743720003082 TPR motif; other site 743720003083 Tetratricopeptide repeat; Region: TPR_12; pfam13424 743720003084 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743720003085 binding surface 743720003086 TPR motif; other site 743720003087 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 743720003088 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 743720003089 tRNA; other site 743720003090 putative tRNA binding site [nucleotide binding]; other site 743720003091 putative NADP binding site [chemical binding]; other site 743720003092 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 743720003093 peptide chain release factor 1; Validated; Region: prfA; PRK00591 743720003094 This domain is found in peptide chain release factors; Region: PCRF; smart00937 743720003095 RF-1 domain; Region: RF-1; pfam00472 743720003096 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 743720003097 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720003098 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 743720003099 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 743720003100 ATP binding site [chemical binding]; other site 743720003101 substrate interface [chemical binding]; other site 743720003102 glutamate racemase; Provisional; Region: PRK00865 743720003103 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 743720003104 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 743720003105 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 743720003106 short chain dehydrogenase; Provisional; Region: PRK08251 743720003107 classical (c) SDRs; Region: SDR_c; cd05233 743720003108 NAD(P) binding site [chemical binding]; other site 743720003109 active site 743720003110 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 743720003111 DNA photolyase; Region: DNA_photolyase; pfam00875 743720003112 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 743720003113 DNA binding residues [nucleotide binding] 743720003114 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 743720003115 Protein of unknown function (DUF523); Region: DUF523; pfam04463 743720003116 Uncharacterized conserved protein [Function unknown]; Region: COG3272 743720003117 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 743720003118 Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493 743720003119 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 743720003120 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 743720003121 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 743720003122 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 743720003123 putative NAD(P) binding site [chemical binding]; other site 743720003124 putative active site [active] 743720003125 ferrochelatase; Reviewed; Region: hemH; PRK00035 743720003126 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 743720003127 C-terminal domain interface [polypeptide binding]; other site 743720003128 active site 743720003129 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 743720003130 active site 743720003131 N-terminal domain interface [polypeptide binding]; other site 743720003132 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 743720003133 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 743720003134 active site 743720003135 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 743720003136 active site 743720003137 putative transporter; Provisional; Region: PRK11660 743720003138 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 743720003139 Sulfate transporter family; Region: Sulfate_transp; pfam00916 743720003140 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 743720003141 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 743720003142 Transposase; Region: DEDD_Tnp_IS110; pfam01548 743720003143 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 743720003144 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 743720003145 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 743720003146 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 743720003147 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 743720003148 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 743720003149 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 743720003150 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 743720003151 S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672 743720003152 putative RNA binding site [nucleotide binding]; other site 743720003153 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 743720003154 acetyl-CoA synthetase; Provisional; Region: PRK00174 743720003155 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 743720003156 active site 743720003157 CoA binding site [chemical binding]; other site 743720003158 acyl-activating enzyme (AAE) consensus motif; other site 743720003159 AMP binding site [chemical binding]; other site 743720003160 acetate binding site [chemical binding]; other site 743720003161 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 743720003162 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 743720003163 active site 743720003164 dimer interface [polypeptide binding]; other site 743720003165 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 743720003166 dimer interface [polypeptide binding]; other site 743720003167 active site 743720003168 Pantoate-beta-alanine ligase; Region: PanC; cd00560 743720003169 pantoate--beta-alanine ligase; Region: panC; TIGR00018 743720003170 active site 743720003171 ATP-binding site [chemical binding]; other site 743720003172 pantoate-binding site; other site 743720003173 HXXH motif; other site 743720003174 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 743720003175 oligomerization interface [polypeptide binding]; other site 743720003176 active site 743720003177 metal binding site [ion binding]; metal-binding site 743720003178 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 743720003179 catalytic center binding site [active] 743720003180 ATP binding site [chemical binding]; other site 743720003181 poly(A) polymerase; Region: pcnB; TIGR01942 743720003182 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 743720003183 active site 743720003184 NTP binding site [chemical binding]; other site 743720003185 metal binding triad [ion binding]; metal-binding site 743720003186 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 743720003187 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 743720003188 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 743720003189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720003190 active site 743720003191 phosphorylation site [posttranslational modification] 743720003192 intermolecular recognition site; other site 743720003193 dimerization interface [polypeptide binding]; other site 743720003194 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720003195 Walker A motif; other site 743720003196 ATP binding site [chemical binding]; other site 743720003197 Walker B motif; other site 743720003198 arginine finger; other site 743720003199 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 743720003200 Na binding site [ion binding]; other site 743720003201 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 743720003202 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720003203 putative active site [active] 743720003204 heme pocket [chemical binding]; other site 743720003205 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720003206 dimer interface [polypeptide binding]; other site 743720003207 phosphorylation site [posttranslational modification] 743720003208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720003209 ATP binding site [chemical binding]; other site 743720003210 Mg2+ binding site [ion binding]; other site 743720003211 G-X-G motif; other site 743720003212 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 743720003213 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 743720003214 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 743720003215 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 743720003216 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 743720003217 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 743720003218 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 743720003219 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 743720003220 metal ion-dependent adhesion site (MIDAS); other site 743720003221 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720003222 gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640 743720003223 Walker A motif; other site 743720003224 ATP binding site [chemical binding]; other site 743720003225 Walker B motif; other site 743720003226 arginine finger; other site 743720003227 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 743720003228 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 743720003229 RDD family; Region: RDD; pfam06271 743720003230 exonuclease I; Provisional; Region: sbcB; PRK11779 743720003231 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 743720003232 active site 743720003233 catalytic site [active] 743720003234 substrate binding site [chemical binding]; other site 743720003235 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 743720003236 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 743720003237 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 743720003238 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 743720003239 putative active site [active] 743720003240 putative substrate binding site [chemical binding]; other site 743720003241 putative cosubstrate binding site; other site 743720003242 catalytic site [active] 743720003243 FOG: CBS domain [General function prediction only]; Region: COG0517 743720003244 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629 743720003245 Cache domain; Region: Cache_1; pfam02743 743720003246 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720003247 dimerization interface [polypeptide binding]; other site 743720003248 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720003249 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720003250 dimer interface [polypeptide binding]; other site 743720003251 putative CheW interface [polypeptide binding]; other site 743720003252 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 743720003253 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 743720003254 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 743720003255 active site 743720003256 catalytic residues [active] 743720003257 Transcriptional regulators [Transcription]; Region: FadR; COG2186 743720003258 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720003259 DNA-binding site [nucleotide binding]; DNA binding site 743720003260 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 743720003261 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 743720003262 EamA-like transporter family; Region: EamA; pfam00892 743720003263 DctM-like transporters; Region: DctM; pfam06808 743720003264 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 743720003265 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 743720003266 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 743720003267 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 743720003268 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 743720003269 Strictosidine synthase; Region: Str_synth; pfam03088 743720003270 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 743720003271 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720003272 active site 743720003273 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 743720003274 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 743720003275 putative active site [active] 743720003276 catalytic residue [active] 743720003277 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 743720003278 Winged helix-turn helix; Region: HTH_29; pfam13551 743720003279 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 743720003280 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 743720003281 Integrase core domain; Region: rve; pfam00665 743720003282 Integrase core domain; Region: rve_3; pfam13683 743720003283 Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970 743720003284 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 743720003285 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 743720003286 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 743720003287 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 743720003288 putative active site [active] 743720003289 catalytic residue [active] 743720003290 Transcriptional regulators [Transcription]; Region: PurR; COG1609 743720003291 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 743720003292 DNA binding site [nucleotide binding] 743720003293 domain linker motif; other site 743720003294 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 743720003295 putative dimerization interface [polypeptide binding]; other site 743720003296 putative ligand binding site [chemical binding]; other site 743720003297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720003298 D-galactonate transporter; Region: 2A0114; TIGR00893 743720003299 putative substrate translocation pore; other site 743720003300 galactarate dehydratase; Region: galactar-dH20; TIGR03248 743720003301 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 743720003302 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 743720003303 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 743720003304 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 743720003305 putative ligand binding site [chemical binding]; other site 743720003306 NAD binding site [chemical binding]; other site 743720003307 catalytic site [active] 743720003308 Transcriptional regulators [Transcription]; Region: GntR; COG1802 743720003309 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720003310 DNA-binding site [nucleotide binding]; DNA binding site 743720003311 FCD domain; Region: FCD; pfam07729 743720003312 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 743720003313 classical (c) SDRs; Region: SDR_c; cd05233 743720003314 NAD(P) binding site [chemical binding]; other site 743720003315 active site 743720003316 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 743720003317 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 743720003318 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 743720003319 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 743720003320 substrate binding site [chemical binding]; other site 743720003321 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 743720003322 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 743720003323 inhibitor-cofactor binding pocket; inhibition site 743720003324 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720003325 catalytic residue [active] 743720003326 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 743720003327 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 743720003328 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 743720003329 Sel1-like repeats; Region: SEL1; smart00671 743720003330 Sel1-like repeats; Region: SEL1; smart00671 743720003331 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 743720003332 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 743720003333 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 743720003334 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 743720003335 non-specific DNA binding site [nucleotide binding]; other site 743720003336 salt bridge; other site 743720003337 sequence-specific DNA binding site [nucleotide binding]; other site 743720003338 Cupin domain; Region: Cupin_2; pfam07883 743720003339 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 743720003340 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 743720003341 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 743720003342 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 743720003343 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 743720003344 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 743720003345 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 743720003346 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 743720003347 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 743720003348 D-pathway; other site 743720003349 Putative ubiquinol binding site [chemical binding]; other site 743720003350 Low-spin heme (heme b) binding site [chemical binding]; other site 743720003351 Putative water exit pathway; other site 743720003352 Binuclear center (heme o3/CuB) [ion binding]; other site 743720003353 K-pathway; other site 743720003354 Putative proton exit pathway; other site 743720003355 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 743720003356 Subunit I/III interface [polypeptide binding]; other site 743720003357 Subunit III/IV interface [polypeptide binding]; other site 743720003358 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 743720003359 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 743720003360 UbiA prenyltransferase family; Region: UbiA; pfam01040 743720003361 S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672 743720003362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720003363 S-adenosylmethionine binding site [chemical binding]; other site 743720003364 outer membrane porin, OprD family; Region: OprD; pfam03573 743720003365 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 743720003366 putative substrate binding pocket [chemical binding]; other site 743720003367 trimer interface [polypeptide binding]; other site 743720003368 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 743720003369 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 743720003370 glycine dehydrogenase; Provisional; Region: PRK05367 743720003371 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 743720003372 tetramer interface [polypeptide binding]; other site 743720003373 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720003374 catalytic residue [active] 743720003375 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 743720003376 tetramer interface [polypeptide binding]; other site 743720003377 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720003378 catalytic residue [active] 743720003379 glycine cleavage system protein H; Provisional; Region: PRK13380 743720003380 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 743720003381 lipoyl attachment site [posttranslational modification]; other site 743720003382 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 743720003383 Tetratricopeptide repeat; Region: TPR_9; pfam13371 743720003384 YebG protein; Region: YebG; pfam07130 743720003385 Predicted membrane protein [Function unknown]; Region: COG3223 743720003386 SWIM zinc finger; Region: SWIM; pfam04434 743720003387 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 743720003388 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743720003389 ATP binding site [chemical binding]; other site 743720003390 putative Mg++ binding site [ion binding]; other site 743720003391 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743720003392 nucleotide binding region [chemical binding]; other site 743720003393 ATP-binding site [chemical binding]; other site 743720003394 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743720003395 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720003396 metal binding site [ion binding]; metal-binding site 743720003397 active site 743720003398 I-site; other site 743720003399 short chain dehydrogenase; Provisional; Region: PRK05693 743720003400 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 743720003401 NADP binding site [chemical binding]; other site 743720003402 active site 743720003403 steroid binding site; other site 743720003404 hypothetical protein; Validated; Region: PRK02101 743720003405 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 743720003406 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 743720003407 putative active site [active] 743720003408 PhoH-like protein; Region: PhoH; pfam02562 743720003409 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 743720003410 trimer interface [polypeptide binding]; other site 743720003411 dimer interface [polypeptide binding]; other site 743720003412 putative active site [active] 743720003413 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 743720003414 MoaE interaction surface [polypeptide binding]; other site 743720003415 MoeB interaction surface [polypeptide binding]; other site 743720003416 thiocarboxylated glycine; other site 743720003417 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 743720003418 MoaE homodimer interface [polypeptide binding]; other site 743720003419 MoaD interaction [polypeptide binding]; other site 743720003420 active site residues [active] 743720003421 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 743720003422 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720003423 ATP-grasp domain; Region: ATP-grasp; pfam02222 743720003424 Domain of unknown function DUF21; Region: DUF21; pfam01595 743720003425 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 743720003426 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 743720003427 Transporter associated domain; Region: CorC_HlyC; smart01091 743720003428 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 743720003429 signal recognition particle protein; Provisional; Region: PRK10867 743720003430 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 743720003431 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 743720003432 P loop; other site 743720003433 GTP binding site [chemical binding]; other site 743720003434 Signal peptide binding domain; Region: SRP_SPB; pfam02978 743720003435 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 743720003436 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 743720003437 RimM N-terminal domain; Region: RimM; pfam01782 743720003438 PRC-barrel domain; Region: PRC; pfam05239 743720003439 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 743720003440 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 743720003441 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 743720003442 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 743720003443 active site 743720003444 Int/Topo IB signature motif; other site 743720003445 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 743720003446 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 743720003447 dimerization domain [polypeptide binding]; other site 743720003448 dimer interface [polypeptide binding]; other site 743720003449 catalytic residues [active] 743720003450 homoserine dehydrogenase; Provisional; Region: PRK06349 743720003451 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 743720003452 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 743720003453 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 743720003454 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 743720003455 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 743720003456 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720003457 catalytic residue [active] 743720003458 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 743720003459 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; pfam09938 743720003460 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 743720003461 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 743720003462 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 743720003463 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 743720003464 ATPase involved in DNA repair; Region: DUF3686; pfam12458 743720003465 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 743720003466 linker region; other site 743720003467 AAA domain; Region: AAA_22; pfam13401 743720003468 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720003469 Walker A motif; other site 743720003470 ATP binding site [chemical binding]; other site 743720003471 Walker B motif; other site 743720003472 Catalytic domain of vertebrate phospholipase D6 and similar proteins; Region: PLDc_vPLD6_like; cd09171 743720003473 PLD-like domain; Region: PLDc_2; pfam13091 743720003474 putative active site [active] 743720003475 catalytic site [active] 743720003476 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK01297 743720003477 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 743720003478 ATP binding site [chemical binding]; other site 743720003479 Mg++ binding site [ion binding]; other site 743720003480 motif III; other site 743720003481 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743720003482 nucleotide binding region [chemical binding]; other site 743720003483 ATP-binding site [chemical binding]; other site 743720003484 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 743720003485 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 743720003486 active site 743720003487 dimer interface [polypeptide binding]; other site 743720003488 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 743720003489 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 743720003490 ligand binding site [chemical binding]; other site 743720003491 flexible hinge region; other site 743720003492 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743720003493 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720003494 metal binding site [ion binding]; metal-binding site 743720003495 active site 743720003496 I-site; other site 743720003497 putative hydrolase; Provisional; Region: PRK11460 743720003498 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 743720003499 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 743720003500 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720003501 substrate binding pocket [chemical binding]; other site 743720003502 membrane-bound complex binding site; other site 743720003503 hinge residues; other site 743720003504 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 743720003505 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720003506 conserved gate region; other site 743720003507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720003508 dimer interface [polypeptide binding]; other site 743720003509 ABC-ATPase subunit interface; other site 743720003510 putative PBP binding loops; other site 743720003511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720003512 dimer interface [polypeptide binding]; other site 743720003513 conserved gate region; other site 743720003514 putative PBP binding loops; other site 743720003515 ABC-ATPase subunit interface; other site 743720003516 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 743720003517 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 743720003518 Walker A/P-loop; other site 743720003519 ATP binding site [chemical binding]; other site 743720003520 Q-loop/lid; other site 743720003521 ABC transporter signature motif; other site 743720003522 Walker B; other site 743720003523 D-loop; other site 743720003524 H-loop/switch region; other site 743720003525 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 743720003526 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 743720003527 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 743720003528 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 743720003529 tetrameric interface [polypeptide binding]; other site 743720003530 NAD binding site [chemical binding]; other site 743720003531 catalytic residues [active] 743720003532 shikimate transporter; Provisional; Region: PRK09952 743720003533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720003534 putative substrate translocation pore; other site 743720003535 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720003536 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720003537 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720003538 dimerization interface [polypeptide binding]; other site 743720003539 SnoaL-like domain; Region: SnoaL_3; pfam13474 743720003540 SnoaL-like domain; Region: SnoaL_2; pfam12680 743720003541 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 743720003542 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 743720003543 GIY-YIG motif/motif A; other site 743720003544 putative active site [active] 743720003545 putative metal binding site [ion binding]; other site 743720003546 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 743720003547 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 743720003548 C-terminal domain interface [polypeptide binding]; other site 743720003549 GSH binding site (G-site) [chemical binding]; other site 743720003550 dimer interface [polypeptide binding]; other site 743720003551 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 743720003552 N-terminal domain interface [polypeptide binding]; other site 743720003553 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 743720003554 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 743720003555 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 743720003556 ethanolamine permease; Region: 2A0305; TIGR00908 743720003557 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 743720003558 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 743720003559 NAD(P) binding site [chemical binding]; other site 743720003560 catalytic residues [active] 743720003561 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 743720003562 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 743720003563 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720003564 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 743720003565 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720003566 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 743720003567 dimerization interface [polypeptide binding]; other site 743720003568 substrate binding pocket [chemical binding]; other site 743720003569 Predicted transcriptional regulators [Transcription]; Region: COG1733 743720003570 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 743720003571 Cupin domain; Region: Cupin_2; pfam07883 743720003572 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 743720003573 2-isopropylmalate synthase; Validated; Region: PRK03739 743720003574 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 743720003575 active site 743720003576 catalytic residues [active] 743720003577 metal binding site [ion binding]; metal-binding site 743720003578 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 743720003579 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720003580 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720003581 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 743720003582 substrate binding pocket [chemical binding]; other site 743720003583 dimerization interface [polypeptide binding]; other site 743720003584 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 743720003585 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 743720003586 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 743720003587 FAD binding domain; Region: FAD_binding_4; pfam01565 743720003588 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 743720003589 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720003590 transcriptional activator TtdR; Provisional; Region: PRK09801 743720003591 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720003592 dimerization interface [polypeptide binding]; other site 743720003593 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 743720003594 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720003595 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720003596 dimerization interface [polypeptide binding]; other site 743720003597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720003598 D-galactonate transporter; Region: 2A0114; TIGR00893 743720003599 putative substrate translocation pore; other site 743720003600 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 743720003601 galactarate dehydratase; Region: galactar-dH20; TIGR03248 743720003602 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 743720003603 succinic semialdehyde dehydrogenase; Region: PLN02278 743720003604 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 743720003605 tetramerization interface [polypeptide binding]; other site 743720003606 NAD(P) binding site [chemical binding]; other site 743720003607 catalytic residues [active] 743720003608 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 743720003609 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 743720003610 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 743720003611 putative ligand binding site [chemical binding]; other site 743720003612 NAD binding site [chemical binding]; other site 743720003613 dimerization interface [polypeptide binding]; other site 743720003614 catalytic site [active] 743720003615 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 743720003616 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 743720003617 inhibitor-cofactor binding pocket; inhibition site 743720003618 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720003619 catalytic residue [active] 743720003620 succinic semialdehyde dehydrogenase; Region: PLN02278 743720003621 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 743720003622 tetramerization interface [polypeptide binding]; other site 743720003623 NAD(P) binding site [chemical binding]; other site 743720003624 catalytic residues [active] 743720003625 outer membrane porin, OprD family; Region: OprD; pfam03573 743720003626 GAF domain; Region: GAF_2; pfam13185 743720003627 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 743720003628 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 743720003629 Amino acid synthesis; Region: AA_synth; pfam06684 743720003630 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 743720003631 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 743720003632 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 743720003633 NAD(P) binding site [chemical binding]; other site 743720003634 catalytic residues [active] 743720003635 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 743720003636 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 743720003637 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 743720003638 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 743720003639 NIPSNAP; Region: NIPSNAP; pfam07978 743720003640 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 743720003641 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 743720003642 Walker A/P-loop; other site 743720003643 ATP binding site [chemical binding]; other site 743720003644 Q-loop/lid; other site 743720003645 ABC transporter signature motif; other site 743720003646 Walker B; other site 743720003647 D-loop; other site 743720003648 H-loop/switch region; other site 743720003649 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 743720003650 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 743720003651 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720003652 dimer interface [polypeptide binding]; other site 743720003653 conserved gate region; other site 743720003654 ABC-ATPase subunit interface; other site 743720003655 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 743720003656 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 743720003657 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 743720003658 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 743720003659 active site 743720003660 catalytic residues [active] 743720003661 transcriptional activator TtdR; Provisional; Region: PRK09801 743720003662 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720003663 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 743720003664 putative effector binding pocket; other site 743720003665 putative dimerization interface [polypeptide binding]; other site 743720003666 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 743720003667 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 743720003668 substrate binding site [chemical binding]; other site 743720003669 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 743720003670 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 743720003671 substrate binding site [chemical binding]; other site 743720003672 ligand binding site [chemical binding]; other site 743720003673 C factor cell-cell signaling protein; Provisional; Region: PRK09009 743720003674 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 743720003675 NADP binding site [chemical binding]; other site 743720003676 homodimer interface [polypeptide binding]; other site 743720003677 active site 743720003678 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 743720003679 catalytic residues [active] 743720003680 Nucleoid-associated protein [General function prediction only]; Region: COG3081 743720003681 nucleoid-associated protein NdpA; Validated; Region: PRK00378 743720003682 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 743720003683 putative active site [active] 743720003684 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743720003685 TPR motif; other site 743720003686 binding surface 743720003687 putative transporter; Provisional; Region: PRK11021 743720003688 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 743720003689 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 743720003690 putative DNA binding site [nucleotide binding]; other site 743720003691 putative Zn2+ binding site [ion binding]; other site 743720003692 AsnC family; Region: AsnC_trans_reg; pfam01037 743720003693 DinB family; Region: DinB; cl17821 743720003694 DinB superfamily; Region: DinB_2; pfam12867 743720003695 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 743720003696 Methyltransferase domain; Region: Methyltransf_31; pfam13847 743720003697 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720003698 S-adenosylmethionine binding site [chemical binding]; other site 743720003699 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743720003700 HAMP domain; Region: HAMP; pfam00672 743720003701 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720003702 dimer interface [polypeptide binding]; other site 743720003703 phosphorylation site [posttranslational modification] 743720003704 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720003705 ATP binding site [chemical binding]; other site 743720003706 Mg2+ binding site [ion binding]; other site 743720003707 G-X-G motif; other site 743720003708 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 743720003709 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720003710 active site 743720003711 phosphorylation site [posttranslational modification] 743720003712 intermolecular recognition site; other site 743720003713 dimerization interface [polypeptide binding]; other site 743720003714 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743720003715 DNA binding site [nucleotide binding] 743720003716 Sulfatase; Region: Sulfatase; pfam00884 743720003717 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 743720003718 active site 743720003719 Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162 743720003720 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 743720003721 Chromate transporter; Region: Chromate_transp; pfam02417 743720003722 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 743720003723 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743720003724 motif II; other site 743720003725 L-type amino acid transporter; Region: 2A0308; TIGR00911 743720003726 Methyltransferase domain; Region: Methyltransf_31; pfam13847 743720003727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720003728 S-adenosylmethionine binding site [chemical binding]; other site 743720003729 exonuclease subunit SbcD; Provisional; Region: PRK10966 743720003730 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 743720003731 active site 743720003732 metal binding site [ion binding]; metal-binding site 743720003733 DNA binding site [nucleotide binding] 743720003734 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 743720003735 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 743720003736 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720003737 dimerization interface [polypeptide binding]; other site 743720003738 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720003739 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720003740 dimer interface [polypeptide binding]; other site 743720003741 putative CheW interface [polypeptide binding]; other site 743720003742 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 743720003743 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720003744 DNA-binding site [nucleotide binding]; DNA binding site 743720003745 UTRA domain; Region: UTRA; pfam07702 743720003746 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 743720003747 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 743720003748 active site 743720003749 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 743720003750 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 743720003751 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 743720003752 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 743720003753 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743720003754 AAA domain; Region: AAA_23; pfam13476 743720003755 Walker A/P-loop; other site 743720003756 ATP binding site [chemical binding]; other site 743720003757 Q-loop/lid; other site 743720003758 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743720003759 ABC transporter signature motif; other site 743720003760 Walker B; other site 743720003761 D-loop; other site 743720003762 H-loop/switch region; other site 743720003763 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 743720003764 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 743720003765 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 743720003766 YaeQ protein; Region: YaeQ; pfam07152 743720003767 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 743720003768 DHH family; Region: DHH; pfam01368 743720003769 DHHA1 domain; Region: DHHA1; pfam02272 743720003770 Protein of unknown function (DUF533); Region: DUF533; pfam04391 743720003771 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 743720003772 putative metal binding site [ion binding]; other site 743720003773 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 743720003774 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 743720003775 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720003776 dimerization interface [polypeptide binding]; other site 743720003777 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720003778 dimer interface [polypeptide binding]; other site 743720003779 putative CheW interface [polypeptide binding]; other site 743720003780 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 743720003781 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 743720003782 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 743720003783 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 743720003784 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 743720003785 putative binding surface; other site 743720003786 active site 743720003787 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 743720003788 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720003789 ATP binding site [chemical binding]; other site 743720003790 Mg2+ binding site [ion binding]; other site 743720003791 G-X-G motif; other site 743720003792 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 743720003793 Response regulator receiver domain; Region: Response_reg; pfam00072 743720003794 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720003795 active site 743720003796 phosphorylation site [posttranslational modification] 743720003797 intermolecular recognition site; other site 743720003798 dimerization interface [polypeptide binding]; other site 743720003799 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 743720003800 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720003801 active site 743720003802 phosphorylation site [posttranslational modification] 743720003803 intermolecular recognition site; other site 743720003804 CheB methylesterase; Region: CheB_methylest; pfam01339 743720003805 Response regulator receiver domain; Region: Response_reg; pfam00072 743720003806 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720003807 active site 743720003808 phosphorylation site [posttranslational modification] 743720003809 intermolecular recognition site; other site 743720003810 dimerization interface [polypeptide binding]; other site 743720003811 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743720003812 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720003813 metal binding site [ion binding]; metal-binding site 743720003814 active site 743720003815 I-site; other site 743720003816 Cache domain; Region: Cache_1; pfam02743 743720003817 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720003818 dimerization interface [polypeptide binding]; other site 743720003819 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743720003820 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720003821 metal binding site [ion binding]; metal-binding site 743720003822 active site 743720003823 I-site; other site 743720003824 peptide chain release factor 2; Validated; Region: prfB; PRK00578 743720003825 This domain is found in peptide chain release factors; Region: PCRF; smart00937 743720003826 RF-1 domain; Region: RF-1; pfam00472 743720003827 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 743720003828 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 743720003829 dimer interface [polypeptide binding]; other site 743720003830 putative anticodon binding site; other site 743720003831 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 743720003832 motif 1; other site 743720003833 active site 743720003834 motif 2; other site 743720003835 motif 3; other site 743720003836 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 743720003837 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 743720003838 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 743720003839 ligand binding site [chemical binding]; other site 743720003840 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 743720003841 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 743720003842 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 743720003843 adenylate kinase; Reviewed; Region: adk; PRK00279 743720003844 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 743720003845 AMP-binding site [chemical binding]; other site 743720003846 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 743720003847 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 743720003848 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 743720003849 Glycoprotease family; Region: Peptidase_M22; pfam00814 743720003850 Protein of unknown function DUF72; Region: DUF72; cl00777 743720003851 Protein of unknown function (DUF1513); Region: DUF1513; pfam07433 743720003852 Imelysin; Region: Peptidase_M75; cl09159 743720003853 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 743720003854 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 743720003855 Imelysin; Region: Peptidase_M75; cl09159 743720003856 biofilm formation regulator HmsP; Provisional; Region: PRK11829 743720003857 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720003858 metal binding site [ion binding]; metal-binding site 743720003859 active site 743720003860 I-site; other site 743720003861 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743720003862 superoxide dismutase; Provisional; Region: PRK10543 743720003863 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 743720003864 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 743720003865 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 743720003866 EamA-like transporter family; Region: EamA; pfam00892 743720003867 LysE type translocator; Region: LysE; cl00565 743720003868 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 743720003869 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720003870 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720003871 dimerization interface [polypeptide binding]; other site 743720003872 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 743720003873 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720003874 NAD(P) binding site [chemical binding]; other site 743720003875 active site 743720003876 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 743720003877 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 743720003878 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 743720003879 FMN binding site [chemical binding]; other site 743720003880 active site 743720003881 substrate binding site [chemical binding]; other site 743720003882 catalytic residue [active] 743720003883 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 743720003884 dimerization interface [polypeptide binding]; other site 743720003885 putative DNA binding site [nucleotide binding]; other site 743720003886 putative Zn2+ binding site [ion binding]; other site 743720003887 Protein of unknown function, DUF479; Region: DUF479; cl01203 743720003888 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720003889 DNA-binding site [nucleotide binding]; DNA binding site 743720003890 Transcriptional regulators [Transcription]; Region: GntR; COG1802 743720003891 DNA-binding site [nucleotide binding]; DNA binding site 743720003892 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 743720003893 FCD domain; Region: FCD; pfam07729 743720003894 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 743720003895 Putative ammonia monooxygenase; Region: AmoA; pfam05145 743720003896 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 743720003897 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 743720003898 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 743720003899 putative acyl-acceptor binding pocket; other site 743720003900 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 743720003901 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 743720003902 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 743720003903 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 743720003904 PLD-like domain; Region: PLDc_2; pfam13091 743720003905 putative active site [active] 743720003906 catalytic site [active] 743720003907 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 743720003908 PLD-like domain; Region: PLDc_2; pfam13091 743720003909 putative active site [active] 743720003910 catalytic site [active] 743720003911 GAF domain; Region: GAF; pfam01590 743720003912 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 743720003913 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720003914 dimer interface [polypeptide binding]; other site 743720003915 phosphorylation site [posttranslational modification] 743720003916 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720003917 ATP binding site [chemical binding]; other site 743720003918 Mg2+ binding site [ion binding]; other site 743720003919 G-X-G motif; other site 743720003920 Hemerythrin-like domain; Region: Hr-like; cd12108 743720003921 Fe binding site [ion binding]; other site 743720003922 PAS fold; Region: PAS_4; pfam08448 743720003923 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720003924 PAS fold; Region: PAS_3; pfam08447 743720003925 putative active site [active] 743720003926 heme pocket [chemical binding]; other site 743720003927 PAS domain S-box; Region: sensory_box; TIGR00229 743720003928 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720003929 putative active site [active] 743720003930 heme pocket [chemical binding]; other site 743720003931 PAS domain S-box; Region: sensory_box; TIGR00229 743720003932 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720003933 putative active site [active] 743720003934 heme pocket [chemical binding]; other site 743720003935 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743720003936 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 743720003937 dimer interface [polypeptide binding]; other site 743720003938 phosphorylation site [posttranslational modification] 743720003939 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720003940 ATP binding site [chemical binding]; other site 743720003941 Mg2+ binding site [ion binding]; other site 743720003942 G-X-G motif; other site 743720003943 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 743720003944 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720003945 active site 743720003946 phosphorylation site [posttranslational modification] 743720003947 intermolecular recognition site; other site 743720003948 dimerization interface [polypeptide binding]; other site 743720003949 histidine kinase; Provisional; Region: PRK13557 743720003950 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720003951 putative active site [active] 743720003952 heme pocket [chemical binding]; other site 743720003953 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720003954 dimer interface [polypeptide binding]; other site 743720003955 phosphorylation site [posttranslational modification] 743720003956 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720003957 ATP binding site [chemical binding]; other site 743720003958 Mg2+ binding site [ion binding]; other site 743720003959 G-X-G motif; other site 743720003960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720003961 active site 743720003962 phosphorylation site [posttranslational modification] 743720003963 intermolecular recognition site; other site 743720003964 dimerization interface [polypeptide binding]; other site 743720003965 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 743720003966 active site 743720003967 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 743720003968 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 743720003969 phosphate binding site [ion binding]; other site 743720003970 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 743720003971 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 743720003972 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 743720003973 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743720003974 N-terminal plug; other site 743720003975 ligand-binding site [chemical binding]; other site 743720003976 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720003977 Coenzyme A binding pocket [chemical binding]; other site 743720003978 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720003979 putative substrate translocation pore; other site 743720003980 Major Facilitator Superfamily; Region: MFS_1; pfam07690 743720003981 Cache domain; Region: Cache_1; pfam02743 743720003982 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720003983 metal binding site [ion binding]; metal-binding site 743720003984 active site 743720003985 I-site; other site 743720003986 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720003987 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720003988 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 743720003989 dimerization interface [polypeptide binding]; other site 743720003990 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 743720003991 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720003992 NAD(P) binding site [chemical binding]; other site 743720003993 active site 743720003994 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 743720003995 classical (c) SDRs; Region: SDR_c; cd05233 743720003996 NAD(P) binding site [chemical binding]; other site 743720003997 active site 743720003998 aminotransferase; Validated; Region: PRK07046 743720003999 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 743720004000 inhibitor-cofactor binding pocket; inhibition site 743720004001 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720004002 catalytic residue [active] 743720004003 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 743720004004 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 743720004005 amidase; Validated; Region: PRK06565 743720004006 Amidase; Region: Amidase; cl11426 743720004007 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 743720004008 Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764 743720004009 Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512 743720004010 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 743720004011 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 743720004012 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 743720004013 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720004014 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 743720004015 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 743720004016 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 743720004017 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 743720004018 dimer interface [polypeptide binding]; other site 743720004019 ADP-ribose binding site [chemical binding]; other site 743720004020 active site 743720004021 nudix motif; other site 743720004022 metal binding site [ion binding]; metal-binding site 743720004023 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 743720004024 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 743720004025 conserved cys residue [active] 743720004026 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720004027 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720004028 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720004029 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 743720004030 substrate binding pocket [chemical binding]; other site 743720004031 dimerization interface [polypeptide binding]; other site 743720004032 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 743720004033 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 743720004034 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 743720004035 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 743720004036 active site 743720004037 metal binding site [ion binding]; metal-binding site 743720004038 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 743720004039 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 743720004040 active site 743720004041 catalytic site [active] 743720004042 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 743720004043 CoA-transferase family III; Region: CoA_transf_3; pfam02515 743720004044 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 743720004045 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 743720004046 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 743720004047 shikimate binding site; other site 743720004048 NAD(P) binding site [chemical binding]; other site 743720004049 Dehydroquinase class II; Region: DHquinase_II; pfam01220 743720004050 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 743720004051 trimer interface [polypeptide binding]; other site 743720004052 active site 743720004053 dimer interface [polypeptide binding]; other site 743720004054 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720004055 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720004056 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 743720004057 putative effector binding pocket; other site 743720004058 putative dimerization interface [polypeptide binding]; other site 743720004059 acetylornithine aminotransferase; Provisional; Region: PRK02627 743720004060 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 743720004061 inhibitor-cofactor binding pocket; inhibition site 743720004062 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720004063 catalytic residue [active] 743720004064 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 743720004065 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720004066 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720004067 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 743720004068 putative dimerization interface [polypeptide binding]; other site 743720004069 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720004070 D-galactonate transporter; Region: 2A0114; TIGR00893 743720004071 putative substrate translocation pore; other site 743720004072 Transcriptional regulators [Transcription]; Region: PurR; COG1609 743720004073 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 743720004074 DNA binding site [nucleotide binding] 743720004075 domain linker motif; other site 743720004076 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 743720004077 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 743720004078 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720004079 active site 743720004080 phosphorylation site [posttranslational modification] 743720004081 intermolecular recognition site; other site 743720004082 dimerization interface [polypeptide binding]; other site 743720004083 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743720004084 DNA binding site [nucleotide binding] 743720004085 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 743720004086 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 743720004087 catalytic residues [active] 743720004088 catalytic nucleophile [active] 743720004089 Presynaptic Site I dimer interface [polypeptide binding]; other site 743720004090 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 743720004091 Synaptic Flat tetramer interface [polypeptide binding]; other site 743720004092 Synaptic Site I dimer interface [polypeptide binding]; other site 743720004093 DNA binding site [nucleotide binding] 743720004094 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 743720004095 DNA-binding interface [nucleotide binding]; DNA binding site 743720004096 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 743720004097 active site residue [active] 743720004098 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 743720004099 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 743720004100 conserved cys residue [active] 743720004101 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720004102 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720004103 putative acetyltransferase; Provisional; Region: PRK03624 743720004104 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720004105 Coenzyme A binding pocket [chemical binding]; other site 743720004106 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 743720004107 Part of AAA domain; Region: AAA_19; pfam13245 743720004108 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 743720004109 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743720004110 Walker A/P-loop; other site 743720004111 ATP binding site [chemical binding]; other site 743720004112 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 743720004113 putative active site [active] 743720004114 putative metal-binding site [ion binding]; other site 743720004115 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 743720004116 GAF domain; Region: GAF; pfam01590 743720004117 PAS domain S-box; Region: sensory_box; TIGR00229 743720004118 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720004119 dimer interface [polypeptide binding]; other site 743720004120 phosphorylation site [posttranslational modification] 743720004121 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720004122 ATP binding site [chemical binding]; other site 743720004123 Mg2+ binding site [ion binding]; other site 743720004124 G-X-G motif; other site 743720004125 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 743720004126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720004127 active site 743720004128 phosphorylation site [posttranslational modification] 743720004129 intermolecular recognition site; other site 743720004130 dimerization interface [polypeptide binding]; other site 743720004131 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 743720004132 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 743720004133 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 743720004134 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720004135 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720004136 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720004137 dimerization interface [polypeptide binding]; other site 743720004138 putative transcriptional regulator; Provisional; Region: PRK11640 743720004139 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 743720004140 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 743720004141 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 743720004142 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 743720004143 putative NAD(P) binding site [chemical binding]; other site 743720004144 putative active site [active] 743720004145 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 743720004146 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720004147 dimerization interface [polypeptide binding]; other site 743720004148 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720004149 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720004150 dimer interface [polypeptide binding]; other site 743720004151 putative CheW interface [polypeptide binding]; other site 743720004152 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 743720004153 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 743720004154 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 743720004155 dimerization interface [polypeptide binding]; other site 743720004156 putative DNA binding site [nucleotide binding]; other site 743720004157 putative Zn2+ binding site [ion binding]; other site 743720004158 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 743720004159 dimerization interface [polypeptide binding]; other site 743720004160 putative DNA binding site [nucleotide binding]; other site 743720004161 putative Zn2+ binding site [ion binding]; other site 743720004162 Low molecular weight phosphatase family; Region: LMWPc; cd00115 743720004163 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 743720004164 active site 743720004165 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 743720004166 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 743720004167 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 743720004168 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720004169 Coenzyme A binding pocket [chemical binding]; other site 743720004170 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 743720004171 arsenical pump membrane protein; Provisional; Region: PRK15445 743720004172 transmembrane helices; other site 743720004173 GAF domain; Region: GAF; pfam01590 743720004174 GAF domain; Region: GAF_2; pfam13185 743720004175 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 743720004176 FecR protein; Region: FecR; pfam04773 743720004177 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 743720004178 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 743720004179 ligand binding site [chemical binding]; other site 743720004180 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 743720004181 CHASE2 domain; Region: CHASE2; pfam05226 743720004182 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 743720004183 cyclase homology domain; Region: CHD; cd07302 743720004184 nucleotidyl binding site; other site 743720004185 metal binding site [ion binding]; metal-binding site 743720004186 dimer interface [polypeptide binding]; other site 743720004187 Transcriptional regulators [Transcription]; Region: MarR; COG1846 743720004188 MarR family; Region: MarR_2; pfam12802 743720004189 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 743720004190 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 743720004191 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 743720004192 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720004193 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720004194 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 743720004195 classical (c) SDRs; Region: SDR_c; cd05233 743720004196 NAD(P) binding site [chemical binding]; other site 743720004197 active site 743720004198 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 743720004199 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720004200 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720004201 dimerization interface [polypeptide binding]; other site 743720004202 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 743720004203 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 743720004204 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 743720004205 aldehyde dehydrogenase family 7 member; Region: PLN02315 743720004206 tetrameric interface [polypeptide binding]; other site 743720004207 NAD binding site [chemical binding]; other site 743720004208 catalytic residues [active] 743720004209 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 743720004210 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720004211 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 743720004212 dimerization interface [polypeptide binding]; other site 743720004213 substrate binding pocket [chemical binding]; other site 743720004214 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 743720004215 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 743720004216 inhibitor-cofactor binding pocket; inhibition site 743720004217 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720004218 catalytic residue [active] 743720004219 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 743720004220 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 743720004221 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 743720004222 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720004223 Coenzyme A binding pocket [chemical binding]; other site 743720004224 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 743720004225 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 743720004226 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 743720004227 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743720004228 HAMP domain; Region: HAMP; pfam00672 743720004229 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720004230 dimer interface [polypeptide binding]; other site 743720004231 phosphorylation site [posttranslational modification] 743720004232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720004233 ATP binding site [chemical binding]; other site 743720004234 Mg2+ binding site [ion binding]; other site 743720004235 G-X-G motif; other site 743720004236 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 743720004237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720004238 active site 743720004239 phosphorylation site [posttranslational modification] 743720004240 intermolecular recognition site; other site 743720004241 dimerization interface [polypeptide binding]; other site 743720004242 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743720004243 DNA binding site [nucleotide binding] 743720004244 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 743720004245 TPR motif; other site 743720004246 binding surface 743720004247 short chain dehydrogenase; Provisional; Region: PRK09072 743720004248 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720004249 NAD(P) binding site [chemical binding]; other site 743720004250 active site 743720004251 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 743720004252 heme binding pocket [chemical binding]; other site 743720004253 heme ligand [chemical binding]; other site 743720004254 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 743720004255 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_3; cd05914 743720004256 acyl-activating enzyme (AAE) consensus motif; other site 743720004257 putative AMP binding site [chemical binding]; other site 743720004258 putative active site [active] 743720004259 putative CoA binding site [chemical binding]; other site 743720004260 Thermostable hemolysin; Region: T_hemolysin; pfam12261 743720004261 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 743720004262 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 743720004263 Beta-lactamase; Region: Beta-lactamase; pfam00144 743720004264 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 743720004265 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 743720004266 Cation efflux family; Region: Cation_efflux; cl00316 743720004267 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 743720004268 Transcriptional regulator [Transcription]; Region: IclR; COG1414 743720004269 Bacterial transcriptional regulator; Region: IclR; pfam01614 743720004270 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 743720004271 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 743720004272 substrate binding site [chemical binding]; other site 743720004273 oxyanion hole (OAH) forming residues; other site 743720004274 trimer interface [polypeptide binding]; other site 743720004275 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 743720004276 CoA binding domain; Region: CoA_binding_2; pfam13380 743720004277 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 743720004278 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 743720004279 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 743720004280 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 743720004281 Walker A/P-loop; other site 743720004282 ATP binding site [chemical binding]; other site 743720004283 Q-loop/lid; other site 743720004284 ABC transporter signature motif; other site 743720004285 Walker B; other site 743720004286 D-loop; other site 743720004287 H-loop/switch region; other site 743720004288 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 743720004289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720004290 dimer interface [polypeptide binding]; other site 743720004291 conserved gate region; other site 743720004292 putative PBP binding loops; other site 743720004293 ABC-ATPase subunit interface; other site 743720004294 NMT1/THI5 like; Region: NMT1; pfam09084 743720004295 NMT1-like family; Region: NMT1_2; pfam13379 743720004296 outer membrane porin, OprD family; Region: OprD; pfam03573 743720004297 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 743720004298 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 743720004299 substrate binding site [chemical binding]; other site 743720004300 oxyanion hole (OAH) forming residues; other site 743720004301 trimer interface [polypeptide binding]; other site 743720004302 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 743720004303 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 743720004304 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 743720004305 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 743720004306 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 743720004307 dimer interface [polypeptide binding]; other site 743720004308 active site 743720004309 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 743720004310 Helix-turn-helix domain; Region: HTH_18; pfam12833 743720004311 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 743720004312 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 743720004313 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 743720004314 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 743720004315 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 743720004316 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 743720004317 SnoaL-like domain; Region: SnoaL_2; pfam12680 743720004318 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 743720004319 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720004320 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 743720004321 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 743720004322 THF binding site; other site 743720004323 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 743720004324 substrate binding site [chemical binding]; other site 743720004325 THF binding site; other site 743720004326 zinc-binding site [ion binding]; other site 743720004327 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 743720004328 Isochorismatase family; Region: Isochorismatase; pfam00857 743720004329 catalytic triad [active] 743720004330 conserved cis-peptide bond; other site 743720004331 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 743720004332 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 743720004333 conserved cys residue [active] 743720004334 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720004335 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 743720004336 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 743720004337 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743720004338 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743720004339 DNA binding residues [nucleotide binding] 743720004340 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 743720004341 FecR protein; Region: FecR; pfam04773 743720004342 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 743720004343 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743720004344 N-terminal plug; other site 743720004345 ligand-binding site [chemical binding]; other site 743720004346 putative fumarate hydratase; Provisional; Region: PRK15392 743720004347 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 743720004348 Fumarase C-terminus; Region: Fumerase_C; pfam05683 743720004349 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743720004350 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720004351 metal binding site [ion binding]; metal-binding site 743720004352 active site 743720004353 I-site; other site 743720004354 hypothetical protein; Provisional; Region: PRK05713 743720004355 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 743720004356 catalytic loop [active] 743720004357 iron binding site [ion binding]; other site 743720004358 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194 743720004359 FAD binding pocket [chemical binding]; other site 743720004360 FAD binding motif [chemical binding]; other site 743720004361 phosphate binding motif [ion binding]; other site 743720004362 beta-alpha-beta structure motif; other site 743720004363 NAD binding pocket [chemical binding]; other site 743720004364 pyruvate kinase; Provisional; Region: PRK05826 743720004365 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 743720004366 domain interfaces; other site 743720004367 active site 743720004368 universal stress protein UspE; Provisional; Region: PRK11175 743720004369 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 743720004370 Ligand Binding Site [chemical binding]; other site 743720004371 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 743720004372 Ligand Binding Site [chemical binding]; other site 743720004373 Tetratricopeptide repeat; Region: TPR_16; pfam13432 743720004374 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 743720004375 PilZ domain; Region: PilZ; pfam07238 743720004376 Ferredoxin [Energy production and conversion]; Region: COG1146 743720004377 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 743720004378 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 743720004379 MutS domain I; Region: MutS_I; pfam01624 743720004380 MutS domain II; Region: MutS_II; pfam05188 743720004381 MutS domain III; Region: MutS_III; pfam05192 743720004382 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 743720004383 Walker A/P-loop; other site 743720004384 ATP binding site [chemical binding]; other site 743720004385 Q-loop/lid; other site 743720004386 ABC transporter signature motif; other site 743720004387 Walker B; other site 743720004388 D-loop; other site 743720004389 H-loop/switch region; other site 743720004390 Competence-damaged protein; Region: CinA; pfam02464 743720004391 recombinase A; Provisional; Region: recA; PRK09354 743720004392 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 743720004393 hexamer interface [polypeptide binding]; other site 743720004394 Walker A motif; other site 743720004395 ATP binding site [chemical binding]; other site 743720004396 Walker B motif; other site 743720004397 recombination regulator RecX; Reviewed; Region: recX; PRK00117 743720004398 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 743720004399 Domain of unknown function (DUF4146); Region: DUF4146; pfam13652 743720004400 Uncharacterized conserved protein [Function unknown]; Region: COG3148 743720004401 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 743720004402 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720004403 active site 743720004404 phosphorylation site [posttranslational modification] 743720004405 intermolecular recognition site; other site 743720004406 dimerization interface [polypeptide binding]; other site 743720004407 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 743720004408 DNA binding residues [nucleotide binding] 743720004409 dimerization interface [polypeptide binding]; other site 743720004410 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 743720004411 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 743720004412 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720004413 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 743720004414 putative dimerization interface [polypeptide binding]; other site 743720004415 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 743720004416 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 743720004417 FAD binding pocket [chemical binding]; other site 743720004418 FAD binding motif [chemical binding]; other site 743720004419 phosphate binding motif [ion binding]; other site 743720004420 beta-alpha-beta structure motif; other site 743720004421 NAD binding pocket [chemical binding]; other site 743720004422 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 743720004423 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 743720004424 heme binding site [chemical binding]; other site 743720004425 ferroxidase pore; other site 743720004426 ferroxidase diiron center [ion binding]; other site 743720004427 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 743720004428 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 743720004429 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 743720004430 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 743720004431 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 743720004432 dimer interface [polypeptide binding]; other site 743720004433 catalytic site [active] 743720004434 putative active site [active] 743720004435 putative substrate binding site [chemical binding]; other site 743720004436 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 743720004437 active site 743720004438 substrate binding pocket [chemical binding]; other site 743720004439 dimer interface [polypeptide binding]; other site 743720004440 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 743720004441 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 743720004442 ligand binding site [chemical binding]; other site 743720004443 argininosuccinate synthase; Provisional; Region: PRK13820 743720004444 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 743720004445 ANP binding site [chemical binding]; other site 743720004446 Substrate Binding Site II [chemical binding]; other site 743720004447 Substrate Binding Site I [chemical binding]; other site 743720004448 HopJ type III effector protein; Region: HopJ; pfam08888 743720004449 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 743720004450 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 743720004451 homooctamer interface [polypeptide binding]; other site 743720004452 active site 743720004453 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 743720004454 homodecamer interface [polypeptide binding]; other site 743720004455 GTP cyclohydrolase I; Provisional; Region: PLN03044 743720004456 active site 743720004457 putative catalytic site residues [active] 743720004458 zinc binding site [ion binding]; other site 743720004459 GTP-CH-I/GFRP interaction surface; other site 743720004460 dihydromonapterin reductase; Provisional; Region: PRK06483 743720004461 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720004462 NAD(P) binding site [chemical binding]; other site 743720004463 active site 743720004464 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 743720004465 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 743720004466 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 743720004467 DNA binding residues [nucleotide binding] 743720004468 B12 binding domain; Region: B12-binding_2; pfam02607 743720004469 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720004470 PAS domain; Region: PAS_9; pfam13426 743720004471 putative active site [active] 743720004472 heme pocket [chemical binding]; other site 743720004473 flavodoxin; Provisional; Region: PRK05723 743720004474 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 743720004475 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 743720004476 putative aromatic amino acid binding site; other site 743720004477 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720004478 Walker A motif; other site 743720004479 ATP binding site [chemical binding]; other site 743720004480 Walker B motif; other site 743720004481 arginine finger; other site 743720004482 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 743720004483 Coenzyme A transferase; Region: CoA_trans; cl17247 743720004484 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 743720004485 malonate decarboxylase subunit delta; Provisional; Region: PRK01220 743720004486 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 743720004487 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 743720004488 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 743720004489 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 743720004490 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 743720004491 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 743720004492 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 743720004493 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 743720004494 Malonate transporter MadL subunit; Region: MadL; pfam03817 743720004495 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 743720004496 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720004497 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720004498 The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416 743720004499 putative dimerization interface [polypeptide binding]; other site 743720004500 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 743720004501 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 743720004502 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 743720004503 Walker A/P-loop; other site 743720004504 ATP binding site [chemical binding]; other site 743720004505 Q-loop/lid; other site 743720004506 ABC transporter signature motif; other site 743720004507 Walker B; other site 743720004508 D-loop; other site 743720004509 H-loop/switch region; other site 743720004510 ABC-2 type transporter; Region: ABC2_membrane; cl17235 743720004511 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 743720004512 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 743720004513 putative active site [active] 743720004514 putative CoA binding site [chemical binding]; other site 743720004515 nudix motif; other site 743720004516 metal binding site [ion binding]; metal-binding site 743720004517 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 743720004518 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 743720004519 trimer interface [polypeptide binding]; other site 743720004520 putative metal binding site [ion binding]; other site 743720004521 Predicted Fe-S protein [General function prediction only]; Region: COG3313 743720004522 Predicted membrane protein [Function unknown]; Region: COG3650 743720004523 Protein of unknown function, DUF488; Region: DUF488; cl01246 743720004524 NIPSNAP; Region: NIPSNAP; pfam07978 743720004525 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720004526 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720004527 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 743720004528 dimerization interface [polypeptide binding]; other site 743720004529 Predicted membrane protein [Function unknown]; Region: COG4125 743720004530 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 743720004531 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 743720004532 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 743720004533 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 743720004534 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 743720004535 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 743720004536 active site 743720004537 GMP synthase; Reviewed; Region: guaA; PRK00074 743720004538 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 743720004539 AMP/PPi binding site [chemical binding]; other site 743720004540 candidate oxyanion hole; other site 743720004541 catalytic triad [active] 743720004542 potential glutamine specificity residues [chemical binding]; other site 743720004543 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 743720004544 ATP Binding subdomain [chemical binding]; other site 743720004545 Ligand Binding sites [chemical binding]; other site 743720004546 Dimerization subdomain; other site 743720004547 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001 743720004548 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720004549 metal binding site [ion binding]; metal-binding site 743720004550 active site 743720004551 I-site; other site 743720004552 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743720004553 Predicted membrane protein [Function unknown]; Region: COG2860 743720004554 UPF0126 domain; Region: UPF0126; pfam03458 743720004555 UPF0126 domain; Region: UPF0126; pfam03458 743720004556 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 743720004557 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 743720004558 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 743720004559 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 743720004560 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 743720004561 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 743720004562 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 743720004563 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 743720004564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720004565 dimer interface [polypeptide binding]; other site 743720004566 conserved gate region; other site 743720004567 putative PBP binding loops; other site 743720004568 ABC-ATPase subunit interface; other site 743720004569 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720004570 dimer interface [polypeptide binding]; other site 743720004571 conserved gate region; other site 743720004572 putative PBP binding loops; other site 743720004573 ABC-ATPase subunit interface; other site 743720004574 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 743720004575 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 743720004576 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 743720004577 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 743720004578 nucleoside/Zn binding site; other site 743720004579 dimer interface [polypeptide binding]; other site 743720004580 catalytic motif [active] 743720004581 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 743720004582 short chain dehydrogenase; Provisional; Region: PRK06482 743720004583 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 743720004584 NADP binding site [chemical binding]; other site 743720004585 active site 743720004586 steroid binding site; other site 743720004587 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720004588 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720004589 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 743720004590 putative effector binding pocket; other site 743720004591 putative dimerization interface [polypeptide binding]; other site 743720004592 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 743720004593 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720004594 substrate binding pocket [chemical binding]; other site 743720004595 membrane-bound complex binding site; other site 743720004596 hinge residues; other site 743720004597 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 743720004598 N-acetyl-D-glucosamine binding site [chemical binding]; other site 743720004599 catalytic residue [active] 743720004600 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 743720004601 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 743720004602 dimerization interface [polypeptide binding]; other site 743720004603 ATP binding site [chemical binding]; other site 743720004604 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 743720004605 dimerization interface [polypeptide binding]; other site 743720004606 ATP binding site [chemical binding]; other site 743720004607 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 743720004608 putative active site [active] 743720004609 catalytic triad [active] 743720004610 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 743720004611 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 743720004612 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 743720004613 Pirin-related protein [General function prediction only]; Region: COG1741 743720004614 Pirin; Region: Pirin; pfam02678 743720004615 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720004616 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720004617 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 743720004618 putative effector binding pocket; other site 743720004619 dimerization interface [polypeptide binding]; other site 743720004620 methionine aminotransferase; Validated; Region: PRK09082 743720004621 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743720004622 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720004623 homodimer interface [polypeptide binding]; other site 743720004624 catalytic residue [active] 743720004625 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 743720004626 C-N hydrolase family amidase; Provisional; Region: PRK10438 743720004627 putative active site [active] 743720004628 catalytic triad [active] 743720004629 dimer interface [polypeptide binding]; other site 743720004630 multimer interface [polypeptide binding]; other site 743720004631 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 743720004632 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 743720004633 putative NAD(P) binding site [chemical binding]; other site 743720004634 putative substrate binding site [chemical binding]; other site 743720004635 catalytic Zn binding site [ion binding]; other site 743720004636 structural Zn binding site [ion binding]; other site 743720004637 dimer interface [polypeptide binding]; other site 743720004638 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720004639 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720004640 LysR substrate binding domain; Region: LysR_substrate; pfam03466 743720004641 dimerization interface [polypeptide binding]; other site 743720004642 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 743720004643 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 743720004644 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 743720004645 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 743720004646 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 743720004647 NAD(P) binding site [chemical binding]; other site 743720004648 catalytic residues [active] 743720004649 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 743720004650 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 743720004651 Peptidase C26; Region: Peptidase_C26; pfam07722 743720004652 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 743720004653 catalytic triad [active] 743720004654 amino acid transporter; Region: 2A0306; TIGR00909 743720004655 2-isopropylmalate synthase; Validated; Region: PRK03739 743720004656 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 743720004657 active site 743720004658 catalytic residues [active] 743720004659 metal binding site [ion binding]; metal-binding site 743720004660 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 743720004661 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 743720004662 Mechanosensitive ion channel; Region: MS_channel; pfam00924 743720004663 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 743720004664 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 743720004665 putative C-terminal domain interface [polypeptide binding]; other site 743720004666 putative GSH binding site (G-site) [chemical binding]; other site 743720004667 putative dimer interface [polypeptide binding]; other site 743720004668 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 743720004669 putative N-terminal domain interface [polypeptide binding]; other site 743720004670 putative dimer interface [polypeptide binding]; other site 743720004671 putative substrate binding pocket (H-site) [chemical binding]; other site 743720004672 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 743720004673 Peptidase family M23; Region: Peptidase_M23; pfam01551 743720004674 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 743720004675 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 743720004676 generic binding surface II; other site 743720004677 generic binding surface I; other site 743720004678 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720004679 dimerization interface [polypeptide binding]; other site 743720004680 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720004681 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720004682 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 743720004683 putative effector binding pocket; other site 743720004684 putative dimerization interface [polypeptide binding]; other site 743720004685 short chain dehydrogenase; Provisional; Region: PRK05854 743720004686 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 743720004687 putative NAD(P) binding site [chemical binding]; other site 743720004688 active site 743720004689 TLC ATP/ADP transporter; Region: TLC; cl03940 743720004690 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 743720004691 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 743720004692 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 743720004693 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743720004694 FeS/SAM binding site; other site 743720004695 TRAM domain; Region: TRAM; cl01282 743720004696 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 743720004697 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 743720004698 catalytic residues [active] 743720004699 catalytic nucleophile [active] 743720004700 Recombinase; Region: Recombinase; pfam07508 743720004701 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 743720004702 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 743720004703 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 743720004704 cofactor binding site; other site 743720004705 DNA binding site [nucleotide binding] 743720004706 substrate interaction site [chemical binding]; other site 743720004707 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 743720004708 DHH family; Region: DHH; pfam01368 743720004709 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 743720004710 Uncharacterized conserved protein (DUF2303); Region: DUF2303; cl02338 743720004711 Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112 743720004712 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 743720004713 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 743720004714 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 743720004715 non-specific DNA binding site [nucleotide binding]; other site 743720004716 salt bridge; other site 743720004717 sequence-specific DNA binding site [nucleotide binding]; other site 743720004718 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 743720004719 Catalytic site [active] 743720004720 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 743720004721 non-specific DNA binding site [nucleotide binding]; other site 743720004722 salt bridge; other site 743720004723 sequence-specific DNA binding site [nucleotide binding]; other site 743720004724 phage/conjugal plasmid C-4 type zinc finger protein, TraR family; Region: C4_traR_proteo; TIGR02419 743720004725 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 743720004726 polymerase nucleotide-binding site; other site 743720004727 DNA-binding residues [nucleotide binding]; DNA binding site 743720004728 primase nucleotide-binding site [nucleotide binding]; other site 743720004729 Phage associated DNA primase [General function prediction only]; Region: COG3378 743720004730 Protein of unknown function (DUF754); Region: DUF754; pfam05449 743720004731 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 743720004732 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 743720004733 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 743720004734 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 743720004735 oligomer interface [polypeptide binding]; other site 743720004736 active site residues [active] 743720004737 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 743720004738 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 743720004739 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 743720004740 Global regulator protein family; Region: CsrA; pfam02599 743720004741 Uncharacterized protein family (UPF0257); Region: UPF0257; cl14672 743720004742 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 743720004743 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 743720004744 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 743720004745 Catalytic site [active] 743720004746 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 743720004747 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 743720004748 active site 743720004749 DNA binding site [nucleotide binding] 743720004750 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 743720004751 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 743720004752 Preprotein binding site; other site 743720004753 SecA binding site; other site 743720004754 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 743720004755 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 743720004756 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 743720004757 Predicted integral membrane protein [Function unknown]; Region: COG0392 743720004758 Predicted integral membrane protein [Function unknown]; Region: COG0392 743720004759 Uncharacterized conserved protein [Function unknown]; Region: COG2898 743720004760 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 743720004761 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 743720004762 active site 743720004763 DNA polymerase IV; Validated; Region: PRK02406 743720004764 DNA binding site [nucleotide binding] 743720004765 META domain; Region: META; pfam03724 743720004766 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 743720004767 heme binding pocket [chemical binding]; other site 743720004768 heme ligand [chemical binding]; other site 743720004769 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720004770 dimerization interface [polypeptide binding]; other site 743720004771 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720004772 dimer interface [polypeptide binding]; other site 743720004773 phosphorylation site [posttranslational modification] 743720004774 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720004775 ATP binding site [chemical binding]; other site 743720004776 Mg2+ binding site [ion binding]; other site 743720004777 G-X-G motif; other site 743720004778 Response regulator receiver domain; Region: Response_reg; pfam00072 743720004779 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720004780 active site 743720004781 phosphorylation site [posttranslational modification] 743720004782 intermolecular recognition site; other site 743720004783 dimerization interface [polypeptide binding]; other site 743720004784 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 743720004785 putative binding surface; other site 743720004786 active site 743720004787 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 743720004788 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720004789 active site 743720004790 phosphorylation site [posttranslational modification] 743720004791 intermolecular recognition site; other site 743720004792 dimerization interface [polypeptide binding]; other site 743720004793 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743720004794 DNA binding site [nucleotide binding] 743720004795 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743720004796 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720004797 dimerization interface [polypeptide binding]; other site 743720004798 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720004799 dimer interface [polypeptide binding]; other site 743720004800 phosphorylation site [posttranslational modification] 743720004801 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720004802 ATP binding site [chemical binding]; other site 743720004803 Mg2+ binding site [ion binding]; other site 743720004804 G-X-G motif; other site 743720004805 outer membrane receptor FepA; Provisional; Region: PRK13524 743720004806 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743720004807 N-terminal plug; other site 743720004808 ligand-binding site [chemical binding]; other site 743720004809 Methyltransferase domain; Region: Methyltransf_31; pfam13847 743720004810 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720004811 S-adenosylmethionine binding site [chemical binding]; other site 743720004812 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 743720004813 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 743720004814 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 743720004815 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 743720004816 siderophore binding site; other site 743720004817 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 743720004818 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 743720004819 ABC-ATPase subunit interface; other site 743720004820 dimer interface [polypeptide binding]; other site 743720004821 putative PBP binding regions; other site 743720004822 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 743720004823 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 743720004824 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 743720004825 ABC-ATPase subunit interface; other site 743720004826 dimer interface [polypeptide binding]; other site 743720004827 putative PBP binding regions; other site 743720004828 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 743720004829 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 743720004830 Walker A/P-loop; other site 743720004831 ATP binding site [chemical binding]; other site 743720004832 Q-loop/lid; other site 743720004833 ABC transporter signature motif; other site 743720004834 Walker B; other site 743720004835 D-loop; other site 743720004836 H-loop/switch region; other site 743720004837 cysteine synthase B; Region: cysM; TIGR01138 743720004838 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 743720004839 dimer interface [polypeptide binding]; other site 743720004840 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720004841 catalytic residue [active] 743720004842 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 743720004843 TRAM domain; Region: TRAM; pfam01938 743720004844 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720004845 S-adenosylmethionine binding site [chemical binding]; other site 743720004846 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 743720004847 HD domain; Region: HD_4; pfam13328 743720004848 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 743720004849 synthetase active site [active] 743720004850 NTP binding site [chemical binding]; other site 743720004851 metal binding site [ion binding]; metal-binding site 743720004852 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 743720004853 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 743720004854 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 743720004855 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 743720004856 homodimer interface [polypeptide binding]; other site 743720004857 metal binding site [ion binding]; metal-binding site 743720004858 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 743720004859 homodimer interface [polypeptide binding]; other site 743720004860 active site 743720004861 putative chemical substrate binding site [chemical binding]; other site 743720004862 metal binding site [ion binding]; metal-binding site 743720004863 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831 743720004864 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 743720004865 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 743720004866 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 743720004867 active site 743720004868 substrate binding site [chemical binding]; other site 743720004869 cosubstrate binding site; other site 743720004870 catalytic site [active] 743720004871 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 743720004872 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 743720004873 dimerization interface [polypeptide binding]; other site 743720004874 putative ATP binding site [chemical binding]; other site 743720004875 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 743720004876 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 743720004877 Domain of unknown function DUF20; Region: UPF0118; pfam01594 743720004878 DNA replication initiation factor; Validated; Region: PRK05642 743720004879 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 743720004880 Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842 743720004881 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 743720004882 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 743720004883 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 743720004884 ArsC family; Region: ArsC; pfam03960 743720004885 catalytic residues [active] 743720004886 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 743720004887 PilZ domain; Region: PilZ; pfam07238 743720004888 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 743720004889 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 743720004890 catalytic residues [active] 743720004891 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 743720004892 prolyl-tRNA synthetase; Provisional; Region: PRK09194 743720004893 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 743720004894 dimer interface [polypeptide binding]; other site 743720004895 motif 1; other site 743720004896 active site 743720004897 motif 2; other site 743720004898 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 743720004899 putative deacylase active site [active] 743720004900 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 743720004901 active site 743720004902 motif 3; other site 743720004903 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 743720004904 anticodon binding site; other site 743720004905 outer membrane porin, OprD family; Region: OprD; pfam03573 743720004906 HIT domain; Region: HIT; pfam01230 743720004907 nucleotide binding site/active site [active] 743720004908 HIT family signature motif; other site 743720004909 catalytic residue [active] 743720004910 hypothetical protein; Provisional; Region: PRK00295 743720004911 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 743720004912 putative transposase OrfB; Reviewed; Region: PHA02517 743720004913 Integrase core domain; Region: rve; pfam00665 743720004914 Integrase core domain; Region: rve_3; pfam13683 743720004915 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 743720004916 DNA-binding site [nucleotide binding]; DNA binding site 743720004917 RNA-binding motif; other site 743720004918 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 743720004919 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 743720004920 dimerization interface [polypeptide binding]; other site 743720004921 DPS ferroxidase diiron center [ion binding]; other site 743720004922 ion pore; other site 743720004923 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 743720004924 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 743720004925 dimer interface [polypeptide binding]; other site 743720004926 anticodon binding site; other site 743720004927 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 743720004928 homodimer interface [polypeptide binding]; other site 743720004929 motif 1; other site 743720004930 active site 743720004931 motif 2; other site 743720004932 GAD domain; Region: GAD; pfam02938 743720004933 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 743720004934 active site 743720004935 motif 3; other site 743720004936 hypothetical protein; Validated; Region: PRK00110 743720004937 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 743720004938 active site 743720004939 putative DNA-binding cleft [nucleotide binding]; other site 743720004940 dimer interface [polypeptide binding]; other site 743720004941 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 743720004942 RuvA N terminal domain; Region: RuvA_N; pfam01330 743720004943 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 743720004944 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 743720004945 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720004946 Walker A motif; other site 743720004947 ATP binding site [chemical binding]; other site 743720004948 Walker B motif; other site 743720004949 arginine finger; other site 743720004950 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 743720004951 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 743720004952 active site 743720004953 TolQ protein; Region: tolQ; TIGR02796 743720004954 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 743720004955 TolR protein; Region: tolR; TIGR02801 743720004956 TolA protein; Region: tolA_full; TIGR02794 743720004957 TolA protein; Region: tolA_full; TIGR02794 743720004958 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 743720004959 translocation protein TolB; Provisional; Region: tolB; PRK00178 743720004960 TolB amino-terminal domain; Region: TolB_N; pfam04052 743720004961 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 743720004962 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 743720004963 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 743720004964 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 743720004965 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 743720004966 ligand binding site [chemical binding]; other site 743720004967 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743720004968 binding surface 743720004969 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 743720004970 TPR motif; other site 743720004971 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 743720004972 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743720004973 FeS/SAM binding site; other site 743720004974 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 743720004975 Ligand Binding Site [chemical binding]; other site 743720004976 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 743720004977 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 743720004978 homodimer interface [polypeptide binding]; other site 743720004979 substrate-cofactor binding pocket; other site 743720004980 catalytic residue [active] 743720004981 quinolinate synthetase; Provisional; Region: PRK09375 743720004982 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 743720004983 Peptidase family M48; Region: Peptidase_M48; cl12018 743720004984 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 743720004985 CPxP motif; other site 743720004986 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 743720004987 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 743720004988 catalytic triad [active] 743720004989 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 743720004990 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 743720004991 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 743720004992 dihydrodipicolinate synthase; Region: dapA; TIGR00674 743720004993 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 743720004994 dimer interface [polypeptide binding]; other site 743720004995 active site 743720004996 catalytic residue [active] 743720004997 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 743720004998 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 743720004999 ATP binding site [chemical binding]; other site 743720005000 active site 743720005001 substrate binding site [chemical binding]; other site 743720005002 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 743720005003 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 743720005004 catalytic residues [active] 743720005005 catalytic nucleophile [active] 743720005006 Presynaptic Site I dimer interface [polypeptide binding]; other site 743720005007 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 743720005008 Synaptic Flat tetramer interface [polypeptide binding]; other site 743720005009 Synaptic Site I dimer interface [polypeptide binding]; other site 743720005010 DNA binding site [nucleotide binding] 743720005011 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 743720005012 DNA-binding interface [nucleotide binding]; DNA binding site 743720005013 flagellar accessory protein FlaH; Validated; Region: PRK06067 743720005014 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 743720005015 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 743720005016 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 743720005017 Glutamate binding site [chemical binding]; other site 743720005018 NAD binding site [chemical binding]; other site 743720005019 catalytic residues [active] 743720005020 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 743720005021 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 743720005022 Na binding site [ion binding]; other site 743720005023 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 743720005024 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 743720005025 Transglycosylase; Region: Transgly; cl17702 743720005026 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 743720005027 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 743720005028 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 743720005029 active site 743720005030 catalytic tetrad [active] 743720005031 ATP-dependent helicase HepA; Validated; Region: PRK04914 743720005032 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743720005033 ATP binding site [chemical binding]; other site 743720005034 putative Mg++ binding site [ion binding]; other site 743720005035 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743720005036 nucleotide binding region [chemical binding]; other site 743720005037 ATP-binding site [chemical binding]; other site 743720005038 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 743720005039 Fusaric acid resistance protein family; Region: FUSC; pfam04632 743720005040 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 743720005041 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 743720005042 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 743720005043 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 743720005044 HlyD family secretion protein; Region: HlyD_3; pfam13437 743720005045 cytosine deaminase; Provisional; Region: PRK09230 743720005046 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 743720005047 active site 743720005048 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 743720005049 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 743720005050 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 743720005051 cytosine permease; Provisional; Region: codB; PRK11017 743720005052 Na binding site [ion binding]; other site 743720005053 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 743720005054 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 743720005055 dimer interaction site [polypeptide binding]; other site 743720005056 substrate-binding tunnel; other site 743720005057 active site 743720005058 catalytic site [active] 743720005059 substrate binding site [chemical binding]; other site 743720005060 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 743720005061 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 743720005062 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 743720005063 long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12492 743720005064 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 743720005065 acyl-activating enzyme (AAE) consensus motif; other site 743720005066 putative AMP binding site [chemical binding]; other site 743720005067 putative active site [active] 743720005068 putative CoA binding site [chemical binding]; other site 743720005069 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677 743720005070 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 743720005071 acyl-activating enzyme (AAE) consensus motif; other site 743720005072 putative AMP binding site [chemical binding]; other site 743720005073 putative active site [active] 743720005074 putative CoA binding site [chemical binding]; other site 743720005075 UV-endonuclease UvdE; Region: UvdE; cl10036 743720005076 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 743720005077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720005078 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 743720005079 dimer interface [polypeptide binding]; other site 743720005080 conserved gate region; other site 743720005081 putative PBP binding loops; other site 743720005082 ABC-ATPase subunit interface; other site 743720005083 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 743720005084 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743720005085 Walker A/P-loop; other site 743720005086 ATP binding site [chemical binding]; other site 743720005087 Q-loop/lid; other site 743720005088 ABC transporter signature motif; other site 743720005089 Walker B; other site 743720005090 D-loop; other site 743720005091 H-loop/switch region; other site 743720005092 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 743720005093 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720005094 substrate binding pocket [chemical binding]; other site 743720005095 membrane-bound complex binding site; other site 743720005096 hinge residues; other site 743720005097 selenophosphate synthetase; Provisional; Region: PRK00943 743720005098 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 743720005099 dimerization interface [polypeptide binding]; other site 743720005100 putative ATP binding site [chemical binding]; other site 743720005101 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 743720005102 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 743720005103 active site residue [active] 743720005104 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 743720005105 putative cyanate transporter; Provisional; Region: cynX; PRK09705 743720005106 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 743720005107 MarR family; Region: MarR_2; cl17246 743720005108 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720005109 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720005110 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720005111 dimerization interface [polypeptide binding]; other site 743720005112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720005113 Major Facilitator Superfamily; Region: MFS_1; pfam07690 743720005114 putative substrate translocation pore; other site 743720005115 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 743720005116 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720005117 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720005118 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720005119 dimerization interface [polypeptide binding]; other site 743720005120 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 743720005121 dimerization interface [polypeptide binding]; other site 743720005122 putative DNA binding site [nucleotide binding]; other site 743720005123 putative Zn2+ binding site [ion binding]; other site 743720005124 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 743720005125 Di-iron ligands [ion binding]; other site 743720005126 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 743720005127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720005128 Response regulator receiver domain; Region: Response_reg; pfam00072 743720005129 active site 743720005130 phosphorylation site [posttranslational modification] 743720005131 intermolecular recognition site; other site 743720005132 dimerization interface [polypeptide binding]; other site 743720005133 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 743720005134 DNA binding residues [nucleotide binding] 743720005135 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743720005136 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720005137 dimer interface [polypeptide binding]; other site 743720005138 phosphorylation site [posttranslational modification] 743720005139 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720005140 ATP binding site [chemical binding]; other site 743720005141 Mg2+ binding site [ion binding]; other site 743720005142 G-X-G motif; other site 743720005143 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 743720005144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720005145 active site 743720005146 phosphorylation site [posttranslational modification] 743720005147 intermolecular recognition site; other site 743720005148 dimerization interface [polypeptide binding]; other site 743720005149 putative kissing complex interaction region; other site 743720005150 putative RNA binding sites [nucleotide binding]; other site 743720005151 Activator of osmoprotectant transporter ProP [Signal transduction mechanisms]; Region: ProQ; COG3109 743720005152 ProQ/FINO family; Region: ProQ; pfam04352 743720005153 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 743720005154 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 743720005155 DNA binding residues [nucleotide binding] 743720005156 dimerization interface [polypeptide binding]; other site 743720005157 Predicted amidohydrolase [General function prediction only]; Region: COG0388 743720005158 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 743720005159 putative active site [active] 743720005160 catalytic triad [active] 743720005161 putative dimer interface [polypeptide binding]; other site 743720005162 amino acid transporter; Region: 2A0306; TIGR00909 743720005163 Nuclease-related domain; Region: NERD; pfam08378 743720005164 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 743720005165 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743720005166 ATP binding site [chemical binding]; other site 743720005167 putative Mg++ binding site [ion binding]; other site 743720005168 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743720005169 nucleotide binding region [chemical binding]; other site 743720005170 ATP-binding site [chemical binding]; other site 743720005171 Helicase associated domain (HA2); Region: HA2; pfam04408 743720005172 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 743720005173 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 743720005174 Beta-lactamase; Region: Beta-lactamase; pfam00144 743720005175 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 743720005176 Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Region: ArgF; COG0078 743720005177 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 743720005178 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 743720005179 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 743720005180 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 743720005181 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 743720005182 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 743720005183 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 743720005184 putative molybdopterin cofactor binding site [chemical binding]; other site 743720005185 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 743720005186 putative molybdopterin cofactor binding site; other site 743720005187 oxidoreductase; Provisional; Region: PRK06128 743720005188 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 743720005189 NAD binding site [chemical binding]; other site 743720005190 metal binding site [ion binding]; metal-binding site 743720005191 active site 743720005192 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 743720005193 active site 743720005194 Protein of unknown function (DUF1652); Region: DUF1652; pfam07865 743720005195 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720005196 dimerization interface [polypeptide binding]; other site 743720005197 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720005198 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720005199 dimer interface [polypeptide binding]; other site 743720005200 putative CheW interface [polypeptide binding]; other site 743720005201 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 743720005202 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 743720005203 active site pocket [active] 743720005204 Transcriptional regulators [Transcription]; Region: PurR; COG1609 743720005205 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 743720005206 DNA binding site [nucleotide binding] 743720005207 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 743720005208 putative dimerization interface [polypeptide binding]; other site 743720005209 putative ligand binding site [chemical binding]; other site 743720005210 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 743720005211 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 743720005212 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 743720005213 active site 743720005214 nucleotide binding site [chemical binding]; other site 743720005215 HIGH motif; other site 743720005216 KMSKS motif; other site 743720005217 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 743720005218 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 743720005219 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 743720005220 NAD binding site [chemical binding]; other site 743720005221 catalytic Zn binding site [ion binding]; other site 743720005222 structural Zn binding site [ion binding]; other site 743720005223 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 743720005224 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 743720005225 dinuclear metal binding motif [ion binding]; other site 743720005226 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 743720005227 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 743720005228 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 743720005229 Cu(I) binding site [ion binding]; other site 743720005230 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 743720005231 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 743720005232 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 743720005233 HAMP domain; Region: HAMP; pfam00672 743720005234 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720005235 dimer interface [polypeptide binding]; other site 743720005236 putative CheW interface [polypeptide binding]; other site 743720005237 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 743720005238 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 743720005239 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 743720005240 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 743720005241 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 743720005242 ATP binding site [chemical binding]; other site 743720005243 Mg2+ binding site [ion binding]; other site 743720005244 G-X-G motif; other site 743720005245 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 743720005246 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 743720005247 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720005248 dimer interface [polypeptide binding]; other site 743720005249 phosphorylation site [posttranslational modification] 743720005250 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720005251 ATP binding site [chemical binding]; other site 743720005252 Mg2+ binding site [ion binding]; other site 743720005253 G-X-G motif; other site 743720005254 Response regulator receiver domain; Region: Response_reg; pfam00072 743720005255 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720005256 active site 743720005257 phosphorylation site [posttranslational modification] 743720005258 intermolecular recognition site; other site 743720005259 dimerization interface [polypeptide binding]; other site 743720005260 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 743720005261 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720005262 dimer interface [polypeptide binding]; other site 743720005263 phosphorylation site [posttranslational modification] 743720005264 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720005265 ATP binding site [chemical binding]; other site 743720005266 Mg2+ binding site [ion binding]; other site 743720005267 G-X-G motif; other site 743720005268 Response regulator receiver domain; Region: Response_reg; pfam00072 743720005269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720005270 active site 743720005271 phosphorylation site [posttranslational modification] 743720005272 intermolecular recognition site; other site 743720005273 dimerization interface [polypeptide binding]; other site 743720005274 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 743720005275 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 743720005276 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720005277 dimerization interface [polypeptide binding]; other site 743720005278 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720005279 dimer interface [polypeptide binding]; other site 743720005280 putative CheW interface [polypeptide binding]; other site 743720005281 PAS domain; Region: PAS; smart00091 743720005282 PAS fold; Region: PAS_4; pfam08448 743720005283 putative active site [active] 743720005284 heme pocket [chemical binding]; other site 743720005285 PAS fold; Region: PAS_4; pfam08448 743720005286 PAS fold; Region: PAS_4; pfam08448 743720005287 sensor protein ZraS; Provisional; Region: PRK10364 743720005288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720005289 ATP binding site [chemical binding]; other site 743720005290 G-X-G motif; other site 743720005291 Response regulator receiver domain; Region: Response_reg; pfam00072 743720005292 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720005293 active site 743720005294 phosphorylation site [posttranslational modification] 743720005295 intermolecular recognition site; other site 743720005296 dimerization interface [polypeptide binding]; other site 743720005297 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667 743720005298 nudix motif; other site 743720005299 Predicted membrane protein [Function unknown]; Region: COG2259 743720005300 Protein of unknown function (DUF1652); Region: DUF1652; pfam07865 743720005301 PAS fold; Region: PAS_4; pfam08448 743720005302 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720005303 PAS domain; Region: PAS_9; pfam13426 743720005304 putative active site [active] 743720005305 heme pocket [chemical binding]; other site 743720005306 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743720005307 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720005308 dimer interface [polypeptide binding]; other site 743720005309 phosphorylation site [posttranslational modification] 743720005310 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720005311 ATP binding site [chemical binding]; other site 743720005312 G-X-G motif; other site 743720005313 Response regulator receiver domain; Region: Response_reg; pfam00072 743720005314 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720005315 active site 743720005316 phosphorylation site [posttranslational modification] 743720005317 intermolecular recognition site; other site 743720005318 dimerization interface [polypeptide binding]; other site 743720005319 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743720005320 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720005321 metal binding site [ion binding]; metal-binding site 743720005322 active site 743720005323 I-site; other site 743720005324 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743720005325 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 743720005326 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 743720005327 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 743720005328 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 743720005329 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 743720005330 NAD(P) binding site [chemical binding]; other site 743720005331 active site 743720005332 Predicted transcriptional regulators [Transcription]; Region: COG1733 743720005333 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 743720005334 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 743720005335 Isochorismatase family; Region: Isochorismatase; pfam00857 743720005336 catalytic triad [active] 743720005337 conserved cis-peptide bond; other site 743720005338 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 743720005339 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 743720005340 Sulfate transporter family; Region: Sulfate_transp; pfam00916 743720005341 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 743720005342 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 743720005343 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 743720005344 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 743720005345 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 743720005346 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 743720005347 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 743720005348 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 743720005349 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 743720005350 Cache domain; Region: Cache_1; pfam02743 743720005351 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720005352 dimerization interface [polypeptide binding]; other site 743720005353 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720005354 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720005355 dimer interface [polypeptide binding]; other site 743720005356 putative CheW interface [polypeptide binding]; other site 743720005357 Cache domain; Region: Cache_1; pfam02743 743720005358 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720005359 dimerization interface [polypeptide binding]; other site 743720005360 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720005361 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720005362 dimer interface [polypeptide binding]; other site 743720005363 putative CheW interface [polypeptide binding]; other site 743720005364 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 743720005365 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 743720005366 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 743720005367 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 743720005368 active site 743720005369 Zn binding site [ion binding]; other site 743720005370 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 743720005371 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 743720005372 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720005373 Bacitracin resistance protein BacA; Region: BacA; pfam02673 743720005374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720005375 metabolite-proton symporter; Region: 2A0106; TIGR00883 743720005376 putative substrate translocation pore; other site 743720005377 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 743720005378 HIT family signature motif; other site 743720005379 catalytic residue [active] 743720005380 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 743720005381 EamA-like transporter family; Region: EamA; pfam00892 743720005382 EamA-like transporter family; Region: EamA; pfam00892 743720005383 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 743720005384 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 743720005385 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 743720005386 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720005387 putative substrate translocation pore; other site 743720005388 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 743720005389 peroxiredoxin; Region: AhpC; TIGR03137 743720005390 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 743720005391 dimer interface [polypeptide binding]; other site 743720005392 decamer (pentamer of dimers) interface [polypeptide binding]; other site 743720005393 catalytic triad [active] 743720005394 peroxidatic and resolving cysteines [active] 743720005395 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 743720005396 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 743720005397 catalytic residue [active] 743720005398 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 743720005399 catalytic residues [active] 743720005400 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 743720005401 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743720005402 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 743720005403 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 743720005404 active site 743720005405 Zn binding site [ion binding]; other site 743720005406 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 743720005407 DEAD_2; Region: DEAD_2; pfam06733 743720005408 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 743720005409 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 743720005410 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720005411 PAS domain; Region: PAS_9; pfam13426 743720005412 putative active site [active] 743720005413 heme pocket [chemical binding]; other site 743720005414 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720005415 dimer interface [polypeptide binding]; other site 743720005416 phosphorylation site [posttranslational modification] 743720005417 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720005418 ATP binding site [chemical binding]; other site 743720005419 Mg2+ binding site [ion binding]; other site 743720005420 G-X-G motif; other site 743720005421 circadian clock protein KaiC; Reviewed; Region: PRK09302 743720005422 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 743720005423 Walker A motif; other site 743720005424 ATP binding site [chemical binding]; other site 743720005425 Walker B motif; other site 743720005426 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 743720005427 Walker A motif; other site 743720005428 ATP binding site [chemical binding]; other site 743720005429 Walker B motif; other site 743720005430 Response regulator receiver domain; Region: Response_reg; pfam00072 743720005431 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720005432 active site 743720005433 phosphorylation site [posttranslational modification] 743720005434 intermolecular recognition site; other site 743720005435 dimerization interface [polypeptide binding]; other site 743720005436 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720005437 dimer interface [polypeptide binding]; other site 743720005438 phosphorylation site [posttranslational modification] 743720005439 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720005440 ATP binding site [chemical binding]; other site 743720005441 Mg2+ binding site [ion binding]; other site 743720005442 G-X-G motif; other site 743720005443 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720005444 active site 743720005445 phosphorylation site [posttranslational modification] 743720005446 intermolecular recognition site; other site 743720005447 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 743720005448 FMN binding site [chemical binding]; other site 743720005449 dimer interface [polypeptide binding]; other site 743720005450 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 743720005451 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 743720005452 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 743720005453 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 743720005454 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 743720005455 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 743720005456 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 743720005457 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 743720005458 Substrate binding site; other site 743720005459 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 743720005460 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 743720005461 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 743720005462 putative glycosyl transferase; Provisional; Region: PRK10063 743720005463 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 743720005464 active site 743720005465 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 743720005466 active site 743720005467 GDP-Mannose binding site [chemical binding]; other site 743720005468 dimer interface [polypeptide binding]; other site 743720005469 modified nudix motif 743720005470 metal binding site [ion binding]; metal-binding site 743720005471 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 743720005472 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 743720005473 NADP binding site [chemical binding]; other site 743720005474 active site 743720005475 putative substrate binding site [chemical binding]; other site 743720005476 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 743720005477 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 743720005478 NADP-binding site; other site 743720005479 homotetramer interface [polypeptide binding]; other site 743720005480 substrate binding site [chemical binding]; other site 743720005481 homodimer interface [polypeptide binding]; other site 743720005482 active site 743720005483 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 743720005484 active site 743720005485 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 743720005486 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 743720005487 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 743720005488 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 743720005489 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 743720005490 Bacterial sugar transferase; Region: Bac_transf; pfam02397 743720005491 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 743720005492 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 743720005493 Chain length determinant protein; Region: Wzz; pfam02706 743720005494 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 743720005495 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 743720005496 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 743720005497 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 743720005498 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 743720005499 SLBB domain; Region: SLBB; pfam10531 743720005500 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 743720005501 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 743720005502 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 743720005503 dimerization interface [polypeptide binding]; other site 743720005504 NAD binding site [chemical binding]; other site 743720005505 ligand binding site [chemical binding]; other site 743720005506 catalytic site [active] 743720005507 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 743720005508 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 743720005509 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 743720005510 outer membrane porin, OprD family; Region: OprD; pfam03573 743720005511 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 743720005512 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720005513 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720005514 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 743720005515 putative dimerization interface [polypeptide binding]; other site 743720005516 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 743720005517 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 743720005518 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 743720005519 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 743720005520 Citrate transporter; Region: CitMHS; pfam03600 743720005521 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 743720005522 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 743720005523 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 743720005524 catalytic residues [active] 743720005525 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 743720005526 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 743720005527 DNA binding residues [nucleotide binding] 743720005528 putative dimer interface [polypeptide binding]; other site 743720005529 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 743720005530 isovaleryl-CoA dehydrogenase; Region: PLN02519 743720005531 substrate binding site [chemical binding]; other site 743720005532 FAD binding site [chemical binding]; other site 743720005533 catalytic base [active] 743720005534 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 743720005535 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 743720005536 gamma-carboxygeranoyl-CoA hydratase; Validated; Region: PRK05674 743720005537 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 743720005538 substrate binding site [chemical binding]; other site 743720005539 oxyanion hole (OAH) forming residues; other site 743720005540 trimer interface [polypeptide binding]; other site 743720005541 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 743720005542 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 743720005543 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 743720005544 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 743720005545 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 743720005546 carboxyltransferase (CT) interaction site; other site 743720005547 biotinylation site [posttranslational modification]; other site 743720005548 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 743720005549 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 743720005550 active site 743720005551 catalytic residues [active] 743720005552 metal binding site [ion binding]; metal-binding site 743720005553 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 743720005554 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 743720005555 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 743720005556 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 743720005557 acetyl-CoA acetyltransferase; Provisional; Region: PRK05656 743720005558 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 743720005559 dimer interface [polypeptide binding]; other site 743720005560 active site 743720005561 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 743720005562 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 743720005563 putative acyl-acceptor binding pocket; other site 743720005564 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 743720005565 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 743720005566 active site 743720005567 nucleophile elbow; other site 743720005568 Predicted ATPase [General function prediction only]; Region: COG1485 743720005569 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 743720005570 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 743720005571 non-specific DNA binding site [nucleotide binding]; other site 743720005572 salt bridge; other site 743720005573 sequence-specific DNA binding site [nucleotide binding]; other site 743720005574 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 743720005575 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720005576 Coenzyme A binding pocket [chemical binding]; other site 743720005577 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 743720005578 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 743720005579 putative ADP-ribose binding site [chemical binding]; other site 743720005580 putative active site [active] 743720005581 pyridoxamine kinase; Validated; Region: PRK05756 743720005582 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 743720005583 pyridoxal binding site [chemical binding]; other site 743720005584 dimer interface [polypeptide binding]; other site 743720005585 ATP binding site [chemical binding]; other site 743720005586 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 743720005587 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 743720005588 ligand binding site [chemical binding]; other site 743720005589 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 743720005590 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 743720005591 Walker A/P-loop; other site 743720005592 ATP binding site [chemical binding]; other site 743720005593 Q-loop/lid; other site 743720005594 ABC transporter signature motif; other site 743720005595 Walker B; other site 743720005596 D-loop; other site 743720005597 H-loop/switch region; other site 743720005598 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 743720005599 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 743720005600 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 743720005601 TM-ABC transporter signature motif; other site 743720005602 Transcriptional regulators [Transcription]; Region: PurR; COG1609 743720005603 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 743720005604 DNA binding site [nucleotide binding] 743720005605 domain linker motif; other site 743720005606 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 743720005607 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 743720005608 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 743720005609 substrate binding site [chemical binding]; other site 743720005610 dimer interface [polypeptide binding]; other site 743720005611 ATP binding site [chemical binding]; other site 743720005612 D-ribose pyranase; Provisional; Region: PRK11797 743720005613 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 743720005614 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 743720005615 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 743720005616 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 743720005617 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 743720005618 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743720005619 Walker A/P-loop; other site 743720005620 ATP binding site [chemical binding]; other site 743720005621 Q-loop/lid; other site 743720005622 ABC transporter signature motif; other site 743720005623 Walker B; other site 743720005624 D-loop; other site 743720005625 H-loop/switch region; other site 743720005626 TOBE domain; Region: TOBE_2; pfam08402 743720005627 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 743720005628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720005629 dimer interface [polypeptide binding]; other site 743720005630 conserved gate region; other site 743720005631 putative PBP binding loops; other site 743720005632 ABC-ATPase subunit interface; other site 743720005633 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720005634 dimer interface [polypeptide binding]; other site 743720005635 conserved gate region; other site 743720005636 putative PBP binding loops; other site 743720005637 ABC-ATPase subunit interface; other site 743720005638 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 743720005639 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 743720005640 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 743720005641 transcriptional regulator protein; Region: phnR; TIGR03337 743720005642 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720005643 DNA-binding site [nucleotide binding]; DNA binding site 743720005644 UTRA domain; Region: UTRA; pfam07702 743720005645 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720005646 Major Facilitator Superfamily; Region: MFS_1; pfam07690 743720005647 putative substrate translocation pore; other site 743720005648 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 743720005649 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 743720005650 Uncharacterized conserved protein [Function unknown]; Region: COG1359 743720005651 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 743720005652 DoxX-like family; Region: DoxX_3; pfam13781 743720005653 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 743720005654 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720005655 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 743720005656 putative active site [active] 743720005657 heme pocket [chemical binding]; other site 743720005658 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720005659 putative active site [active] 743720005660 heme pocket [chemical binding]; other site 743720005661 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720005662 dimer interface [polypeptide binding]; other site 743720005663 putative CheW interface [polypeptide binding]; other site 743720005664 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 743720005665 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 743720005666 dimerization interface [polypeptide binding]; other site 743720005667 putative Zn2+ binding site [ion binding]; other site 743720005668 putative DNA binding site [nucleotide binding]; other site 743720005669 AsnC family; Region: AsnC_trans_reg; pfam01037 743720005670 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 743720005671 EamA-like transporter family; Region: EamA; pfam00892 743720005672 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 743720005673 Peptidase family U32; Region: Peptidase_U32; pfam01136 743720005674 Collagenase; Region: DUF3656; pfam12392 743720005675 hypothetical protein; Provisional; Region: PRK10396 743720005676 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 743720005677 SEC-C motif; Region: SEC-C; pfam02810 743720005678 HDOD domain; Region: HDOD; pfam08668 743720005679 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 743720005680 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743720005681 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720005682 metal binding site [ion binding]; metal-binding site 743720005683 active site 743720005684 I-site; other site 743720005685 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 743720005686 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 743720005687 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 743720005688 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743720005689 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720005690 metal binding site [ion binding]; metal-binding site 743720005691 active site 743720005692 I-site; other site 743720005693 Ion channel; Region: Ion_trans_2; pfam07885 743720005694 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 743720005695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720005696 S-adenosylmethionine binding site [chemical binding]; other site 743720005697 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720005698 Coenzyme A binding pocket [chemical binding]; other site 743720005699 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 743720005700 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743720005701 binding surface 743720005702 TPR motif; other site 743720005703 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743720005704 binding surface 743720005705 TPR motif; other site 743720005706 TPR repeat; Region: TPR_11; pfam13414 743720005707 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 743720005708 dimer interface [polypeptide binding]; other site 743720005709 putative radical transfer pathway; other site 743720005710 diiron center [ion binding]; other site 743720005711 tyrosyl radical; other site 743720005712 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 743720005713 ATP cone domain; Region: ATP-cone; pfam03477 743720005714 ATP cone domain; Region: ATP-cone; pfam03477 743720005715 Class I ribonucleotide reductase; Region: RNR_I; cd01679 743720005716 active site 743720005717 dimer interface [polypeptide binding]; other site 743720005718 catalytic residues [active] 743720005719 effector binding site; other site 743720005720 R2 peptide binding site; other site 743720005721 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 743720005722 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 743720005723 active site 743720005724 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 743720005725 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 743720005726 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 743720005727 Switch I; other site 743720005728 Switch II; other site 743720005729 septum formation inhibitor; Reviewed; Region: minC; PRK00339 743720005730 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 743720005731 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 743720005732 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720005733 Coenzyme A binding pocket [chemical binding]; other site 743720005734 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720005735 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720005736 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 743720005737 putative effector binding pocket; other site 743720005738 dimerization interface [polypeptide binding]; other site 743720005739 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 743720005740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720005741 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 743720005742 Bacterial SH3 domain; Region: SH3_3; pfam08239 743720005743 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 743720005744 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720005745 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447 743720005746 putative dimerization interface [polypeptide binding]; other site 743720005747 putative substrate binding pocket [chemical binding]; other site 743720005748 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 743720005749 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720005750 putative substrate translocation pore; other site 743720005751 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 743720005752 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 743720005753 active site 743720005754 tetramer interface [polypeptide binding]; other site 743720005755 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 743720005756 Isochorismatase family; Region: Isochorismatase; pfam00857 743720005757 catalytic triad [active] 743720005758 conserved cis-peptide bond; other site 743720005759 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 743720005760 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 743720005761 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720005762 dimer interface [polypeptide binding]; other site 743720005763 conserved gate region; other site 743720005764 putative PBP binding loops; other site 743720005765 ABC-ATPase subunit interface; other site 743720005766 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720005767 dimer interface [polypeptide binding]; other site 743720005768 conserved gate region; other site 743720005769 putative PBP binding loops; other site 743720005770 ABC-ATPase subunit interface; other site 743720005771 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14263 743720005772 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 743720005773 Walker A/P-loop; other site 743720005774 ATP binding site [chemical binding]; other site 743720005775 Q-loop/lid; other site 743720005776 ABC transporter signature motif; other site 743720005777 Walker B; other site 743720005778 D-loop; other site 743720005779 H-loop/switch region; other site 743720005780 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 743720005781 phosphoglucomutase; Validated; Region: PRK07564 743720005782 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 743720005783 active site 743720005784 substrate binding site [chemical binding]; other site 743720005785 metal binding site [ion binding]; metal-binding site 743720005786 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 743720005787 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 743720005788 dimerization interface [polypeptide binding]; other site 743720005789 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720005790 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720005791 dimer interface [polypeptide binding]; other site 743720005792 putative CheW interface [polypeptide binding]; other site 743720005793 Predicted transcriptional regulator [Transcription]; Region: COG1959 743720005794 Transcriptional regulator; Region: Rrf2; pfam02082 743720005795 Transcriptional regulator; Region: Rrf2; cl17282 743720005796 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 743720005797 Cytochrome c; Region: Cytochrom_C; cl11414 743720005798 trehalose synthase, Pseudomonas stutzeri type; Region: TreS_stutzeri; TIGR02455 743720005799 serine O-acetyltransferase; Region: cysE; TIGR01172 743720005800 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 743720005801 trimer interface [polypeptide binding]; other site 743720005802 active site 743720005803 substrate binding site [chemical binding]; other site 743720005804 CoA binding site [chemical binding]; other site 743720005805 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 743720005806 intersubunit interface [polypeptide binding]; other site 743720005807 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 743720005808 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 743720005809 ABC-ATPase subunit interface; other site 743720005810 dimer interface [polypeptide binding]; other site 743720005811 putative PBP binding regions; other site 743720005812 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 743720005813 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 743720005814 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 743720005815 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 743720005816 metal binding site [ion binding]; metal-binding site 743720005817 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 743720005818 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 743720005819 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 743720005820 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 743720005821 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 743720005822 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 743720005823 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720005824 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 743720005825 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 743720005826 active site 743720005827 FMN binding site [chemical binding]; other site 743720005828 2,4-decadienoyl-CoA binding site; other site 743720005829 catalytic residue [active] 743720005830 4Fe-4S cluster binding site [ion binding]; other site 743720005831 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 743720005832 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 743720005833 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 743720005834 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 743720005835 Domain of unknown function (DUF1853); Region: DUF1853; pfam08907 743720005836 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231 743720005837 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 743720005838 Pseudomonas aeruginosa PA3087 and related proteins, metallophosphatase domain; Region: MPP_PA3087; cd07413 743720005839 active site 743720005840 metal binding site [ion binding]; metal-binding site 743720005841 rhomboid family protease GlpG; Region: rhombo_GlpG; TIGR04239 743720005842 Rhomboid family; Region: Rhomboid; pfam01694 743720005843 Protein of unknown function (DUF1315); Region: DUF1315; pfam07023 743720005844 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 743720005845 aminopeptidase N; Provisional; Region: pepN; PRK14015 743720005846 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 743720005847 active site 743720005848 Zn binding site [ion binding]; other site 743720005849 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 743720005850 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 743720005851 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 743720005852 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 743720005853 Immunity protein Imm1; Region: Imm1; pfam14430 743720005854 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 743720005855 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 743720005856 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 743720005857 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720005858 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720005859 Oxygen tolerance; Region: BatD; pfam13584 743720005860 von Willebrand factor type A domain; Region: VWA_2; pfam13519 743720005861 metal ion-dependent adhesion site (MIDAS); other site 743720005862 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743720005863 TPR repeat; Region: TPR_11; pfam13414 743720005864 binding surface 743720005865 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 743720005866 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 743720005867 metal ion-dependent adhesion site (MIDAS); other site 743720005868 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 743720005869 Protein of unknown function DUF58; Region: DUF58; pfam01882 743720005870 MoxR-like ATPases [General function prediction only]; Region: COG0714 743720005871 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720005872 Walker A motif; other site 743720005873 ATP binding site [chemical binding]; other site 743720005874 Walker B motif; other site 743720005875 arginine finger; other site 743720005876 HAMP domain; Region: HAMP; pfam00672 743720005877 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720005878 dimer interface [polypeptide binding]; other site 743720005879 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 743720005880 putative CheW interface [polypeptide binding]; other site 743720005881 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 743720005882 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 743720005883 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 743720005884 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 743720005885 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 743720005886 Protein of unknown function (DUF2835); Region: DUF2835; pfam11197 743720005887 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 743720005888 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 743720005889 quinone interaction residues [chemical binding]; other site 743720005890 active site 743720005891 catalytic residues [active] 743720005892 FMN binding site [chemical binding]; other site 743720005893 substrate binding site [chemical binding]; other site 743720005894 Ribosome modulation factor; Region: RMF; pfam04957 743720005895 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 743720005896 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 743720005897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 743720005898 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720005899 S-adenosylmethionine binding site [chemical binding]; other site 743720005900 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 743720005901 Protein with unknown function (DUF469); Region: DUF469; cl01237 743720005902 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 743720005903 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 743720005904 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 743720005905 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 743720005906 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743720005907 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 743720005908 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 743720005909 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 743720005910 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 743720005911 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 743720005912 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 743720005913 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 743720005914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720005915 active site 743720005916 phosphorylation site [posttranslational modification] 743720005917 intermolecular recognition site; other site 743720005918 dimerization interface [polypeptide binding]; other site 743720005919 hypothetical protein; Provisional; Region: PRK04860 743720005920 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 743720005921 DNA-J related protein; Region: DNAJ_related; pfam12339 743720005922 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 743720005923 HSP70 interaction site [polypeptide binding]; other site 743720005924 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 743720005925 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 743720005926 Ligand Binding Site [chemical binding]; other site 743720005927 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 743720005928 NAD-dependent deacetylase; Provisional; Region: PRK00481 743720005929 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 743720005930 NAD+ binding site [chemical binding]; other site 743720005931 substrate binding site [chemical binding]; other site 743720005932 Zn binding site [ion binding]; other site 743720005933 NlpC/P60 family; Region: NLPC_P60; pfam00877 743720005934 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 743720005935 NlpC/P60 family; Region: NLPC_P60; pfam00877 743720005936 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 743720005937 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 743720005938 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 743720005939 Walker A motif; other site 743720005940 homodimer interface [polypeptide binding]; other site 743720005941 ATP binding site [chemical binding]; other site 743720005942 hydroxycobalamin binding site [chemical binding]; other site 743720005943 Walker B motif; other site 743720005944 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 743720005945 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 743720005946 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 743720005947 catalytic triad [active] 743720005948 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 743720005949 putative FMN binding site [chemical binding]; other site 743720005950 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 743720005951 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 743720005952 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743720005953 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720005954 homodimer interface [polypeptide binding]; other site 743720005955 catalytic residue [active] 743720005956 cobyric acid synthase; Provisional; Region: PRK00784 743720005957 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 743720005958 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 743720005959 catalytic triad [active] 743720005960 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 743720005961 homotrimer interface [polypeptide binding]; other site 743720005962 Walker A motif; other site 743720005963 GTP binding site [chemical binding]; other site 743720005964 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 743720005965 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 743720005966 putative dimer interface [polypeptide binding]; other site 743720005967 active site pocket [active] 743720005968 putative cataytic base [active] 743720005969 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 743720005970 catalytic core [active] 743720005971 cobalamin synthase; Reviewed; Region: cobS; PRK00235 743720005972 Transcriptional regulators [Transcription]; Region: MarR; COG1846 743720005973 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720005974 Major Facilitator Superfamily; Region: MFS_1; pfam07690 743720005975 putative substrate translocation pore; other site 743720005976 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 743720005977 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 743720005978 catalytic residues [active] 743720005979 dimer interface [polypeptide binding]; other site 743720005980 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 743720005981 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 743720005982 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 743720005983 dimer interface [polypeptide binding]; other site 743720005984 active site 743720005985 catalytic residue [active] 743720005986 ribonuclease D; Region: rnd; TIGR01388 743720005987 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 743720005988 catalytic site [active] 743720005989 putative active site [active] 743720005990 putative substrate binding site [chemical binding]; other site 743720005991 HRDC domain; Region: HRDC; pfam00570 743720005992 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 743720005993 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 743720005994 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 743720005995 NAD binding site [chemical binding]; other site 743720005996 ligand binding site [chemical binding]; other site 743720005997 catalytic site [active] 743720005998 hypothetical protein; Provisional; Region: PRK05170 743720005999 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 743720006000 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 743720006001 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 743720006002 active site 743720006003 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 743720006004 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 743720006005 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 743720006006 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 743720006007 putative active site [active] 743720006008 putative dimer interface [polypeptide binding]; other site 743720006009 Protein of unknown function (DUF2937); Region: DUF2937; pfam11157 743720006010 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 743720006011 Uncharacterized conserved protein [Function unknown]; Region: COG3791 743720006012 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 743720006013 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720006014 Walker A motif; other site 743720006015 ATP binding site [chemical binding]; other site 743720006016 Walker B motif; other site 743720006017 arginine finger; other site 743720006018 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 743720006019 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 743720006020 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 743720006021 dimer interface [polypeptide binding]; other site 743720006022 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720006023 catalytic residue [active] 743720006024 EamA-like transporter family; Region: EamA; pfam00892 743720006025 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 743720006026 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743720006027 N-terminal plug; other site 743720006028 ligand-binding site [chemical binding]; other site 743720006029 PAS domain; Region: PAS_9; pfam13426 743720006030 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720006031 putative active site [active] 743720006032 heme pocket [chemical binding]; other site 743720006033 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720006034 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720006035 dimer interface [polypeptide binding]; other site 743720006036 putative CheW interface [polypeptide binding]; other site 743720006037 DTW domain; Region: DTW; cl01221 743720006038 Pirin-related protein [General function prediction only]; Region: COG1741 743720006039 Pirin; Region: Pirin; pfam02678 743720006040 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 743720006041 VacJ like lipoprotein; Region: VacJ; cl01073 743720006042 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 743720006043 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 743720006044 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 743720006045 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 743720006046 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 743720006047 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 743720006048 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 743720006049 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 743720006050 MgtE intracellular N domain; Region: MgtE_N; smart00924 743720006051 FliG C-terminal domain; Region: FliG_C; pfam01706 743720006052 flagellar assembly protein H; Validated; Region: fliH; PRK05687 743720006053 Flagellar assembly protein FliH; Region: FliH; pfam02108 743720006054 flagellum-specific ATP synthase; Validated; Region: fliI; PRK05688 743720006055 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 743720006056 Walker A motif/ATP binding site; other site 743720006057 Walker B motif; other site 743720006058 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 743720006059 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 743720006060 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 743720006061 anti sigma factor interaction site; other site 743720006062 regulatory phosphorylation site [posttranslational modification]; other site 743720006063 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 743720006064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720006065 active site 743720006066 phosphorylation site [posttranslational modification] 743720006067 intermolecular recognition site; other site 743720006068 dimerization interface [polypeptide binding]; other site 743720006069 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 743720006070 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 743720006071 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 743720006072 ATP binding site [chemical binding]; other site 743720006073 Mg2+ binding site [ion binding]; other site 743720006074 G-X-G motif; other site 743720006075 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 743720006076 putative binding surface; other site 743720006077 active site 743720006078 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 743720006079 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK05696 743720006080 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 743720006081 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 743720006082 flagellar motor switch protein; Validated; Region: fliN; PRK05698 743720006083 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 743720006084 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 743720006085 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 743720006086 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 743720006087 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 743720006088 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 743720006089 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 743720006090 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 743720006091 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 743720006092 P-class dimer interface [polypeptide binding]; other site 743720006093 active site 743720006094 Cu2+ binding site [ion binding]; other site 743720006095 E-class dimer interface [polypeptide binding]; other site 743720006096 Zn2+ binding site [ion binding]; other site 743720006097 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 743720006098 FHIPEP family; Region: FHIPEP; pfam00771 743720006099 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 743720006100 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 743720006101 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 743720006102 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 743720006103 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 743720006104 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 743720006105 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743720006106 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 743720006107 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743720006108 DNA binding residues [nucleotide binding] 743720006109 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 743720006110 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720006111 active site 743720006112 phosphorylation site [posttranslational modification] 743720006113 intermolecular recognition site; other site 743720006114 dimerization interface [polypeptide binding]; other site 743720006115 Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344 743720006116 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 743720006117 putative binding surface; other site 743720006118 active site 743720006119 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 743720006120 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 743720006121 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720006122 ATP binding site [chemical binding]; other site 743720006123 Mg2+ binding site [ion binding]; other site 743720006124 G-X-G motif; other site 743720006125 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 743720006126 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 743720006127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720006128 active site 743720006129 phosphorylation site [posttranslational modification] 743720006130 intermolecular recognition site; other site 743720006131 dimerization interface [polypeptide binding]; other site 743720006132 CheB methylesterase; Region: CheB_methylest; pfam01339 743720006133 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 743720006134 flagellar motor protein; Reviewed; Region: motC; PRK09109 743720006135 flagellar motor protein MotD; Reviewed; Region: PRK09038 743720006136 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 743720006137 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 743720006138 ligand binding site [chemical binding]; other site 743720006139 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 743720006140 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 743720006141 P-loop; other site 743720006142 Magnesium ion binding site [ion binding]; other site 743720006143 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 743720006144 Magnesium ion binding site [ion binding]; other site 743720006145 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 743720006146 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 743720006147 putative CheA interaction surface; other site 743720006148 Protein of unknown function (DUF2802); Region: DUF2802; pfam10975 743720006149 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 743720006150 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 743720006151 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 743720006152 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 743720006153 Walker A/P-loop; other site 743720006154 ATP binding site [chemical binding]; other site 743720006155 Q-loop/lid; other site 743720006156 ABC transporter signature motif; other site 743720006157 Walker B; other site 743720006158 D-loop; other site 743720006159 H-loop/switch region; other site 743720006160 heme exporter protein CcmB; Region: ccmB; TIGR01190 743720006161 heme exporter protein CcmC; Region: ccmC; TIGR01191 743720006162 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 743720006163 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 743720006164 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 743720006165 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 743720006166 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 743720006167 catalytic residues [active] 743720006168 central insert; other site 743720006169 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 743720006170 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 743720006171 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 743720006172 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 743720006173 binding surface 743720006174 TPR motif; other site 743720006175 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 743720006176 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 743720006177 Bacterial transcriptional regulator; Region: IclR; pfam01614 743720006178 short chain dehydrogenase; Provisional; Region: PRK05650 743720006179 classical (c) SDRs; Region: SDR_c; cd05233 743720006180 NAD(P) binding site [chemical binding]; other site 743720006181 active site 743720006182 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 743720006183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720006184 putative substrate translocation pore; other site 743720006185 hypothetical protein; Provisional; Region: PRK00304 743720006186 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 743720006187 IHF dimer interface [polypeptide binding]; other site 743720006188 IHF - DNA interface [nucleotide binding]; other site 743720006189 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 743720006190 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720006191 dimerization interface [polypeptide binding]; other site 743720006192 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720006193 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720006194 dimer interface [polypeptide binding]; other site 743720006195 putative CheW interface [polypeptide binding]; other site 743720006196 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 743720006197 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 743720006198 putative oligomer interface [polypeptide binding]; other site 743720006199 putative active site [active] 743720006200 metal binding site [ion binding]; metal-binding site 743720006201 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 743720006202 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720006203 Coenzyme A binding pocket [chemical binding]; other site 743720006204 ATP-grasp domain; Region: ATP-grasp_4; cl17255 743720006205 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 743720006206 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 743720006207 active site 743720006208 dimer interface [polypeptide binding]; other site 743720006209 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 743720006210 Ligand Binding Site [chemical binding]; other site 743720006211 Molecular Tunnel; other site 743720006212 Transposase IS200 like; Region: Y1_Tnp; pfam01797 743720006213 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 743720006214 Uncharacterized conserved protein [Function unknown]; Region: COG4121 743720006215 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 743720006216 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 743720006217 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 743720006218 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 743720006219 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 743720006220 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 743720006221 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 743720006222 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 743720006223 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743720006224 ATP binding site [chemical binding]; other site 743720006225 putative Mg++ binding site [ion binding]; other site 743720006226 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743720006227 nucleotide binding region [chemical binding]; other site 743720006228 ATP-binding site [chemical binding]; other site 743720006229 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 743720006230 HRDC domain; Region: HRDC; pfam00570 743720006231 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 743720006232 MarR family; Region: MarR_2; pfam12802 743720006233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720006234 Major Facilitator Superfamily; Region: MFS_1; pfam07690 743720006235 putative substrate translocation pore; other site 743720006236 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 743720006237 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 743720006238 Rdx family; Region: Rdx; cl01407 743720006239 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 743720006240 dimer interface [polypeptide binding]; other site 743720006241 putative tRNA-binding site [nucleotide binding]; other site 743720006242 Cupin domain; Region: Cupin_2; cl17218 743720006243 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720006244 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 743720006245 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720006246 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 743720006247 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 743720006248 putative active site [active] 743720006249 putative metal binding site [ion binding]; other site 743720006250 MASE2 domain; Region: MASE2; pfam05230 743720006251 Chordopoxvirus G3 protein; Region: Chordopox_G3; cl17332 743720006252 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 743720006253 cyclase homology domain; Region: CHD; cd07302 743720006254 nucleotidyl binding site; other site 743720006255 metal binding site [ion binding]; metal-binding site 743720006256 dimer interface [polypeptide binding]; other site 743720006257 Protein of unknown function (DUF962); Region: DUF962; cl01879 743720006258 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 743720006259 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 743720006260 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 743720006261 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 743720006262 putative FMN binding site [chemical binding]; other site 743720006263 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743720006264 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720006265 dimerization interface [polypeptide binding]; other site 743720006266 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 743720006267 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720006268 ATP binding site [chemical binding]; other site 743720006269 G-X-G motif; other site 743720006270 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 743720006271 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 743720006272 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720006273 active site 743720006274 phosphorylation site [posttranslational modification] 743720006275 intermolecular recognition site; other site 743720006276 dimerization interface [polypeptide binding]; other site 743720006277 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743720006278 DNA binding site [nucleotide binding] 743720006279 YciI-like protein; Reviewed; Region: PRK11370 743720006280 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 743720006281 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 743720006282 active site 743720006283 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 743720006284 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 743720006285 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 743720006286 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 743720006287 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 743720006288 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 743720006289 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 743720006290 RNA binding surface [nucleotide binding]; other site 743720006291 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 743720006292 probable active site [active] 743720006293 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743720006294 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720006295 metal binding site [ion binding]; metal-binding site 743720006296 active site 743720006297 I-site; other site 743720006298 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 743720006299 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720006300 NAD(P) binding site [chemical binding]; other site 743720006301 active site 743720006302 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 743720006303 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 743720006304 phosphoglycolate phosphatase; Provisional; Region: PRK13222 743720006305 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743720006306 motif II; other site 743720006307 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 743720006308 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 743720006309 catalytic residue [active] 743720006310 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 743720006311 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720006312 S-adenosylmethionine binding site [chemical binding]; other site 743720006313 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 743720006314 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 743720006315 active site 743720006316 putative substrate binding pocket [chemical binding]; other site 743720006317 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 743720006318 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 743720006319 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit [DNA replication, recombination, and repair]; Region: GyrA; COG0188 743720006320 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 743720006321 CAP-like domain; other site 743720006322 active site 743720006323 primary dimer interface [polypeptide binding]; other site 743720006324 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 743720006325 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 743720006326 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 743720006327 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 743720006328 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 743720006329 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 743720006330 homodimer interface [polypeptide binding]; other site 743720006331 substrate-cofactor binding pocket; other site 743720006332 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720006333 catalytic residue [active] 743720006334 Chorismate mutase type II; Region: CM_2; cl00693 743720006335 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 743720006336 Prephenate dehydratase; Region: PDT; pfam00800 743720006337 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 743720006338 putative L-Phe binding site [chemical binding]; other site 743720006339 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 743720006340 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743720006341 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720006342 homodimer interface [polypeptide binding]; other site 743720006343 catalytic residue [active] 743720006344 bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK14806 743720006345 prephenate dehydrogenase; Validated; Region: PRK08507 743720006346 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 743720006347 hinge; other site 743720006348 active site 743720006349 cytidylate kinase; Provisional; Region: cmk; PRK00023 743720006350 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 743720006351 CMP-binding site; other site 743720006352 The sites determining sugar specificity; other site 743720006353 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 743720006354 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 743720006355 RNA binding site [nucleotide binding]; other site 743720006356 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 743720006357 RNA binding site [nucleotide binding]; other site 743720006358 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 743720006359 RNA binding site [nucleotide binding]; other site 743720006360 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 743720006361 RNA binding site [nucleotide binding]; other site 743720006362 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 743720006363 RNA binding site [nucleotide binding]; other site 743720006364 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 743720006365 RNA binding site [nucleotide binding]; other site 743720006366 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 743720006367 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 743720006368 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 743720006369 putative alpha subunit interface [polypeptide binding]; other site 743720006370 putative active site [active] 743720006371 putative substrate binding site [chemical binding]; other site 743720006372 Fe binding site [ion binding]; other site 743720006373 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 743720006374 inter-subunit interface; other site 743720006375 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 743720006376 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 743720006377 catalytic loop [active] 743720006378 iron binding site [ion binding]; other site 743720006379 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 743720006380 FAD binding pocket [chemical binding]; other site 743720006381 FAD binding motif [chemical binding]; other site 743720006382 phosphate binding motif [ion binding]; other site 743720006383 beta-alpha-beta structure motif; other site 743720006384 NAD binding pocket [chemical binding]; other site 743720006385 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 743720006386 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 743720006387 putative NAD(P) binding site [chemical binding]; other site 743720006388 active site 743720006389 benzoate transport; Region: 2A0115; TIGR00895 743720006390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720006391 putative substrate translocation pore; other site 743720006392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720006393 Benzoate membrane transport protein; Region: BenE; pfam03594 743720006394 benzoate transporter; Region: benE; TIGR00843 743720006395 outer membrane porin, OprD family; Region: OprD; pfam03573 743720006396 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 743720006397 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720006398 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720006399 dimerization interface [polypeptide binding]; other site 743720006400 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 743720006401 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 743720006402 octamer interface [polypeptide binding]; other site 743720006403 active site 743720006404 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 743720006405 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 743720006406 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 743720006407 dimer interface [polypeptide binding]; other site 743720006408 active site 743720006409 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 743720006410 Helix-turn-helix domain; Region: HTH_18; pfam12833 743720006411 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 743720006412 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 743720006413 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 743720006414 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 743720006415 dimer interface [polypeptide binding]; other site 743720006416 active site 743720006417 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 743720006418 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720006419 putative substrate translocation pore; other site 743720006420 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 743720006421 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 743720006422 tetramer interface [polypeptide binding]; other site 743720006423 active site 743720006424 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 743720006425 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 743720006426 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720006427 dimerization interface [polypeptide binding]; other site 743720006428 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 743720006429 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720006430 dimer interface [polypeptide binding]; other site 743720006431 putative CheW interface [polypeptide binding]; other site 743720006432 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 743720006433 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720006434 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 743720006435 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 743720006436 NAD(P) binding site [chemical binding]; other site 743720006437 catalytic residues [active] 743720006438 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 743720006439 active site 743720006440 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 743720006441 C-terminal domain of type I, class II extradiol dioxygenases; catalytic domain; Region: ED_TypeI_classII_C; cd08343 743720006442 active site 743720006443 metal binding site [ion binding]; metal-binding site 743720006444 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 743720006445 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 743720006446 Transcriptional regulator [Transcription]; Region: IclR; COG1414 743720006447 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 743720006448 Bacterial transcriptional regulator; Region: IclR; pfam01614 743720006449 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 743720006450 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 743720006451 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 743720006452 benzoate transport; Region: 2A0115; TIGR00895 743720006453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720006454 putative substrate translocation pore; other site 743720006455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720006456 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 743720006457 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 743720006458 NAD(P) binding site [chemical binding]; other site 743720006459 catalytic residues [active] 743720006460 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 743720006461 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 743720006462 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 743720006463 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 743720006464 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 743720006465 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 743720006466 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743720006467 Walker A/P-loop; other site 743720006468 ATP binding site [chemical binding]; other site 743720006469 Q-loop/lid; other site 743720006470 ABC transporter signature motif; other site 743720006471 Walker B; other site 743720006472 D-loop; other site 743720006473 H-loop/switch region; other site 743720006474 GTP cyclohydrolase I; Provisional; Region: PLN03044 743720006475 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 743720006476 homodecamer interface [polypeptide binding]; other site 743720006477 active site 743720006478 putative catalytic site residues [active] 743720006479 zinc binding site [ion binding]; other site 743720006480 GTP-CH-I/GFRP interaction surface; other site 743720006481 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 743720006482 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 743720006483 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 743720006484 phosphogluconate dehydratase; Validated; Region: PRK09054 743720006485 6-phosphogluconate dehydratase; Region: edd; TIGR01196 743720006486 glucokinase; Provisional; Region: glk; PRK00292 743720006487 glucokinase, proteobacterial type; Region: glk; TIGR00749 743720006488 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 743720006489 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720006490 active site 743720006491 phosphorylation site [posttranslational modification] 743720006492 intermolecular recognition site; other site 743720006493 dimerization interface [polypeptide binding]; other site 743720006494 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743720006495 DNA binding site [nucleotide binding] 743720006496 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 743720006497 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720006498 ATP binding site [chemical binding]; other site 743720006499 Mg2+ binding site [ion binding]; other site 743720006500 G-X-G motif; other site 743720006501 dimerization interface [polypeptide binding]; other site 743720006502 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 743720006503 putative active cleft [active] 743720006504 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 743720006505 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 743720006506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720006507 dimer interface [polypeptide binding]; other site 743720006508 conserved gate region; other site 743720006509 putative PBP binding loops; other site 743720006510 ABC-ATPase subunit interface; other site 743720006511 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 743720006512 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720006513 dimer interface [polypeptide binding]; other site 743720006514 conserved gate region; other site 743720006515 putative PBP binding loops; other site 743720006516 ABC-ATPase subunit interface; other site 743720006517 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 743720006518 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 743720006519 Walker A/P-loop; other site 743720006520 ATP binding site [chemical binding]; other site 743720006521 Q-loop/lid; other site 743720006522 ABC transporter signature motif; other site 743720006523 Walker B; other site 743720006524 D-loop; other site 743720006525 H-loop/switch region; other site 743720006526 TOBE domain; Region: TOBE_2; pfam08402 743720006527 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 743720006528 trimer interface; other site 743720006529 sugar binding site [chemical binding]; other site 743720006530 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 743720006531 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 743720006532 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 743720006533 putative active site [active] 743720006534 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 743720006535 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 743720006536 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 743720006537 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 743720006538 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 743720006539 putative active site [active] 743720006540 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 743720006541 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 743720006542 active site 743720006543 intersubunit interface [polypeptide binding]; other site 743720006544 catalytic residue [active] 743720006545 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 743720006546 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 743720006547 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 743720006548 shikimate binding site; other site 743720006549 NAD(P) binding site [chemical binding]; other site 743720006550 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 743720006551 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 743720006552 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 743720006553 ATP-dependent DNA ligase; Validated; Region: PRK09247 743720006554 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 743720006555 active site 743720006556 DNA binding site [nucleotide binding] 743720006557 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 743720006558 DNA binding site [nucleotide binding] 743720006559 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 743720006560 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743720006561 ATP binding site [chemical binding]; other site 743720006562 putative Mg++ binding site [ion binding]; other site 743720006563 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743720006564 nucleotide binding region [chemical binding]; other site 743720006565 ATP-binding site [chemical binding]; other site 743720006566 DEAD/H associated; Region: DEAD_assoc; pfam08494 743720006567 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 743720006568 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 743720006569 putative active site [active] 743720006570 putative metal binding site [ion binding]; other site 743720006571 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 743720006572 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720006573 dimerization interface [polypeptide binding]; other site 743720006574 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720006575 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720006576 dimer interface [polypeptide binding]; other site 743720006577 putative CheW interface [polypeptide binding]; other site 743720006578 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 743720006579 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 743720006580 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 743720006581 Tetramer interface [polypeptide binding]; other site 743720006582 active site 743720006583 FMN-binding site [chemical binding]; other site 743720006584 phenyl proprionate permease family protein; Region: 2A0127; TIGR00902 743720006585 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720006586 putative substrate translocation pore; other site 743720006587 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 743720006588 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 743720006589 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 743720006590 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 743720006591 DNA binding site [nucleotide binding] 743720006592 active site 743720006593 AlkA N-terminal domain; Region: AlkA_N; pfam06029 743720006594 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 743720006595 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 743720006596 minor groove reading motif; other site 743720006597 helix-hairpin-helix signature motif; other site 743720006598 substrate binding pocket [chemical binding]; other site 743720006599 active site 743720006600 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 743720006601 Sulfatase; Region: Sulfatase; pfam00884 743720006602 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 743720006603 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 743720006604 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 743720006605 active site 743720006606 Zn binding site [ion binding]; other site 743720006607 Uncharacterized conserved protein [Function unknown]; Region: COG2308 743720006608 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 743720006609 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 743720006610 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 743720006611 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 743720006612 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 743720006613 Predicted permeases [General function prediction only]; Region: COG0679 743720006614 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 743720006615 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 743720006616 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 743720006617 catalytic triad [active] 743720006618 malate:quinone oxidoreductase; Validated; Region: PRK05257 743720006619 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 743720006620 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 743720006621 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 743720006622 NAD(P) binding site [chemical binding]; other site 743720006623 catalytic residues [active] 743720006624 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720006625 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720006626 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 743720006627 putative effector binding pocket; other site 743720006628 dimerization interface [polypeptide binding]; other site 743720006629 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 743720006630 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 743720006631 active site 743720006632 dimer interface [polypeptide binding]; other site 743720006633 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 743720006634 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 743720006635 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 743720006636 Domain of unknown function (DUF4404); Region: DUF4404; pfam14357 743720006637 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 743720006638 Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853 743720006639 PilZ domain; Region: PilZ; pfam07238 743720006640 Response regulator receiver domain; Region: Response_reg; pfam00072 743720006641 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720006642 active site 743720006643 phosphorylation site [posttranslational modification] 743720006644 intermolecular recognition site; other site 743720006645 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 743720006646 dimerization interface [polypeptide binding]; other site 743720006647 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 743720006648 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 743720006649 anti sigma factor interaction site; other site 743720006650 regulatory phosphorylation site [posttranslational modification]; other site 743720006651 transaldolase-like protein; Provisional; Region: PTZ00411 743720006652 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 743720006653 active site 743720006654 dimer interface [polypeptide binding]; other site 743720006655 catalytic residue [active] 743720006656 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 743720006657 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 743720006658 FMN binding site [chemical binding]; other site 743720006659 active site 743720006660 catalytic residues [active] 743720006661 substrate binding site [chemical binding]; other site 743720006662 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 743720006663 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 743720006664 active site 743720006665 DNA binding site [nucleotide binding] 743720006666 Int/Topo IB signature motif; other site 743720006667 Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112 743720006668 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 743720006669 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 743720006670 sequence-specific DNA binding site [nucleotide binding]; other site 743720006671 salt bridge; other site 743720006672 Plasmid maintenance system killer protein; Region: Plasmid_killer; pfam05015 743720006673 Protein of unknown function (DUF2274); Region: DUF2274; pfam10038 743720006674 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 743720006675 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 743720006676 VirB7 interaction site; other site 743720006677 conjugal transfer protein TrbF; Provisional; Region: PRK13872 743720006678 conjugal transfer protein TrbL; Provisional; Region: PRK13875 743720006679 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 743720006680 conjugal transfer protein TrbJ; Provisional; Region: PRK13874 743720006681 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 743720006682 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 743720006683 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 743720006684 Walker A motif; other site 743720006685 ATP binding site [chemical binding]; other site 743720006686 Walker B motif; other site 743720006687 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743720006688 Walker B; other site 743720006689 D-loop; other site 743720006690 H-loop/switch region; other site 743720006691 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 743720006692 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 743720006693 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 743720006694 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 743720006695 ATP binding site [chemical binding]; other site 743720006696 Walker A motif; other site 743720006697 hexamer interface [polypeptide binding]; other site 743720006698 Walker B motif; other site 743720006699 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 743720006700 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 743720006701 Walker A motif; other site 743720006702 ATP binding site [chemical binding]; other site 743720006703 Walker B motif; other site 743720006704 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720006705 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720006706 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720006707 dimerization interface [polypeptide binding]; other site 743720006708 hypothetical protein; Provisional; Region: PRK10621 743720006709 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 743720006710 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720006711 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720006712 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 743720006713 dimerization interface [polypeptide binding]; other site 743720006714 substrate binding pocket [chemical binding]; other site 743720006715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720006716 MFS transport protein AraJ; Provisional; Region: PRK10091 743720006717 putative substrate translocation pore; other site 743720006718 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 743720006719 active site 743720006720 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 743720006721 dimer interface [polypeptide binding]; other site 743720006722 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 743720006723 Ligand Binding Site [chemical binding]; other site 743720006724 Molecular Tunnel; other site 743720006725 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 743720006726 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 743720006727 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 743720006728 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720006729 Coenzyme A binding pocket [chemical binding]; other site 743720006730 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 743720006731 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 743720006732 substrate-cofactor binding pocket; other site 743720006733 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720006734 catalytic residue [active] 743720006735 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 743720006736 salt bridge; other site 743720006737 non-specific DNA binding site [nucleotide binding]; other site 743720006738 sequence-specific DNA binding site [nucleotide binding]; other site 743720006739 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 743720006740 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 743720006741 Type IV secretory pathway, protease TraF [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: TraF; COG4959 743720006742 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 743720006743 ParA-like protein; Provisional; Region: PHA02518 743720006744 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 743720006745 P-loop; other site 743720006746 Magnesium ion binding site [ion binding]; other site 743720006747 Replication initiator protein A; Region: RPA; pfam10134 743720006748 Helix-turn-helix domain; Region: HTH_17; pfam12728 743720006749 Global regulator protein family; Region: CsrA; pfam02599 743720006750 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 743720006751 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720006752 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 743720006753 Coenzyme A binding pocket [chemical binding]; other site 743720006754 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 743720006755 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720006756 DNA-binding site [nucleotide binding]; DNA binding site 743720006757 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743720006758 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720006759 homodimer interface [polypeptide binding]; other site 743720006760 catalytic residue [active] 743720006761 benzoate transporter; Region: benE; TIGR00843 743720006762 Benzoate membrane transport protein; Region: BenE; pfam03594 743720006763 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 743720006764 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 743720006765 catalytic residue [active] 743720006766 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 743720006767 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 743720006768 dimer interface [polypeptide binding]; other site 743720006769 active site 743720006770 glycine-pyridoxal phosphate binding site [chemical binding]; other site 743720006771 folate binding site [chemical binding]; other site 743720006772 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 743720006773 putative metal binding site [ion binding]; other site 743720006774 Uncharacterized conserved protein [Function unknown]; Region: COG1432 743720006775 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 743720006776 hypothetical protein; Reviewed; Region: PRK00024 743720006777 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 743720006778 MPN+ (JAMM) motif; other site 743720006779 Zinc-binding site [ion binding]; other site 743720006780 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 743720006781 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 743720006782 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720006783 Coenzyme A binding pocket [chemical binding]; other site 743720006784 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 743720006785 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 743720006786 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 743720006787 RNA polymerase sigma factor; Provisional; Region: PRK12528 743720006788 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743720006789 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743720006790 DNA binding residues [nucleotide binding] 743720006791 fec operon regulator FecR; Reviewed; Region: PRK09774 743720006792 FecR protein; Region: FecR; pfam04773 743720006793 Secretin and TonB N terminus short domain; Region: STN; smart00965 743720006794 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 743720006795 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743720006796 N-terminal plug; other site 743720006797 ligand-binding site [chemical binding]; other site 743720006798 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720006799 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720006800 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 743720006801 dimerization interface [polypeptide binding]; other site 743720006802 putative effector binding pocket; other site 743720006803 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 743720006804 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 743720006805 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 743720006806 ATP binding site [chemical binding]; other site 743720006807 Mg2+ binding site [ion binding]; other site 743720006808 G-X-G motif; other site 743720006809 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 743720006810 His-Xaa-Ser system radical SAM maturase HxsC; Region: rSAM_pair_HxsC; TIGR03977 743720006811 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743720006812 FeS/SAM binding site; other site 743720006813 His-Xaa-Ser system radical SAM maturase HxsB; Region: rSAM_paired_1; TIGR03978 743720006814 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743720006815 FeS/SAM binding site; other site 743720006816 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 743720006817 His-Xaa-Ser system protein HsxD; Region: chp_LLNDYxLRE; TIGR03976 743720006818 Part of AAA domain; Region: AAA_19; pfam13245 743720006819 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 743720006820 AAA domain; Region: AAA_30; pfam13604 743720006821 AAA domain; Region: AAA_12; pfam13087 743720006822 haemagglutination activity domain; Region: Haemagg_act; pfam05860 743720006823 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 743720006824 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 743720006825 Surface antigen; Region: Bac_surface_Ag; pfam01103 743720006826 Arc-like DNA binding domain; Region: Arc; pfam03869 743720006827 DNA-specific endonuclease I; Provisional; Region: PRK15137 743720006828 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 743720006829 Nitrate and nitrite sensing; Region: NIT; pfam08376 743720006830 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 743720006831 HAMP domain; Region: HAMP; pfam00672 743720006832 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720006833 dimer interface [polypeptide binding]; other site 743720006834 putative CheW interface [polypeptide binding]; other site 743720006835 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720006836 PAS domain; Region: PAS_9; pfam13426 743720006837 putative active site [active] 743720006838 heme pocket [chemical binding]; other site 743720006839 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720006840 PAS fold; Region: PAS_3; pfam08447 743720006841 putative active site [active] 743720006842 heme pocket [chemical binding]; other site 743720006843 PAS domain S-box; Region: sensory_box; TIGR00229 743720006844 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720006845 putative active site [active] 743720006846 heme pocket [chemical binding]; other site 743720006847 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743720006848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720006849 ATP binding site [chemical binding]; other site 743720006850 Mg2+ binding site [ion binding]; other site 743720006851 G-X-G motif; other site 743720006852 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 743720006853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720006854 active site 743720006855 phosphorylation site [posttranslational modification] 743720006856 intermolecular recognition site; other site 743720006857 dimerization interface [polypeptide binding]; other site 743720006858 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 743720006859 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 743720006860 ligand binding site [chemical binding]; other site 743720006861 flexible hinge region; other site 743720006862 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 743720006863 non-specific DNA interactions [nucleotide binding]; other site 743720006864 DNA binding site [nucleotide binding] 743720006865 sequence specific DNA binding site [nucleotide binding]; other site 743720006866 putative cAMP binding site [chemical binding]; other site 743720006867 CsbD-like; Region: CsbD; cl17424 743720006868 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 743720006869 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 743720006870 active site 743720006871 Putative glucoamylase; Region: Glycoamylase; pfam10091 743720006872 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 743720006873 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 743720006874 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 743720006875 Response regulator receiver domain; Region: Response_reg; pfam00072 743720006876 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720006877 active site 743720006878 phosphorylation site [posttranslational modification] 743720006879 intermolecular recognition site; other site 743720006880 dimerization interface [polypeptide binding]; other site 743720006881 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 743720006882 Zn2+ binding site [ion binding]; other site 743720006883 Mg2+ binding site [ion binding]; other site 743720006884 AAA domain; Region: AAA_33; pfam13671 743720006885 AAA domain; Region: AAA_17; pfam13207 743720006886 RNA ligase; Region: RNA_ligase; pfam09414 743720006887 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720006888 DNA-binding site [nucleotide binding]; DNA binding site 743720006889 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 743720006890 UTRA domain; Region: UTRA; pfam07702 743720006891 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 743720006892 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 743720006893 active site turn [active] 743720006894 phosphorylation site [posttranslational modification] 743720006895 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 743720006896 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 743720006897 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 743720006898 Ca binding site [ion binding]; other site 743720006899 active site 743720006900 catalytic site [active] 743720006901 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 743720006902 HPr interaction site; other site 743720006903 glycerol kinase (GK) interaction site [polypeptide binding]; other site 743720006904 active site 743720006905 phosphorylation site [posttranslational modification] 743720006906 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 743720006907 dimerization domain swap beta strand [polypeptide binding]; other site 743720006908 regulatory protein interface [polypeptide binding]; other site 743720006909 active site 743720006910 regulatory phosphorylation site [posttranslational modification]; other site 743720006911 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 743720006912 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 743720006913 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 743720006914 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 743720006915 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 743720006916 active site turn [active] 743720006917 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 743720006918 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 743720006919 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 743720006920 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 743720006921 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720006922 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720006923 D-galactonate transporter; Region: 2A0114; TIGR00893 743720006924 putative substrate translocation pore; other site 743720006925 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 743720006926 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 743720006927 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 743720006928 classical (c) SDRs; Region: SDR_c; cd05233 743720006929 NAD(P) binding site [chemical binding]; other site 743720006930 active site 743720006931 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 743720006932 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 743720006933 putative ligand binding site [chemical binding]; other site 743720006934 NAD binding site [chemical binding]; other site 743720006935 catalytic site [active] 743720006936 Domain of unknown function DUF; Region: DUF204; pfam02659 743720006937 Domain of unknown function DUF; Region: DUF204; pfam02659 743720006938 YhhN-like protein; Region: YhhN; cl01505 743720006939 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 743720006940 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 743720006941 Trp docking motif [polypeptide binding]; other site 743720006942 putative active site [active] 743720006943 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 743720006944 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 743720006945 putative ligand binding residues [chemical binding]; other site 743720006946 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 743720006947 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 743720006948 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 743720006949 dimer interface [polypeptide binding]; other site 743720006950 putative PBP binding regions; other site 743720006951 ABC-ATPase subunit interface; other site 743720006952 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 743720006953 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 743720006954 Walker A/P-loop; other site 743720006955 ATP binding site [chemical binding]; other site 743720006956 Q-loop/lid; other site 743720006957 ABC transporter signature motif; other site 743720006958 Walker B; other site 743720006959 D-loop; other site 743720006960 H-loop/switch region; other site 743720006961 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 743720006962 pseudoazurin; Region: pseudoazurin; TIGR02375 743720006963 multidrug resistance protein MdtH; Provisional; Region: PRK11646 743720006964 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720006965 outer membrane porin, OprD family; Region: OprD; pfam03573 743720006966 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 743720006967 Mechanosensitive ion channel; Region: MS_channel; pfam00924 743720006968 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 743720006969 Prostaglandin dehydrogenases; Region: PGDH; cd05288 743720006970 NAD(P) binding site [chemical binding]; other site 743720006971 substrate binding site [chemical binding]; other site 743720006972 dimer interface [polypeptide binding]; other site 743720006973 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 743720006974 Sodium Bile acid symporter family; Region: SBF; cl17470 743720006975 benzoate transporter; Region: benE; TIGR00843 743720006976 Benzoate membrane transport protein; Region: BenE; pfam03594 743720006977 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 743720006978 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 743720006979 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 743720006980 putative DNA binding site [nucleotide binding]; other site 743720006981 putative Zn2+ binding site [ion binding]; other site 743720006982 aspartate aminotransferase; Provisional; Region: PRK05764 743720006983 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743720006984 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720006985 homodimer interface [polypeptide binding]; other site 743720006986 catalytic residue [active] 743720006987 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 743720006988 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 743720006989 putative C-terminal domain interface [polypeptide binding]; other site 743720006990 putative GSH binding site (G-site) [chemical binding]; other site 743720006991 putative dimer interface [polypeptide binding]; other site 743720006992 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 743720006993 N-terminal domain interface [polypeptide binding]; other site 743720006994 dimer interface [polypeptide binding]; other site 743720006995 substrate binding pocket (H-site) [chemical binding]; other site 743720006996 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 743720006997 Heavy-metal-associated domain; Region: HMA; pfam00403 743720006998 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 743720006999 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743720007000 motif II; other site 743720007001 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 743720007002 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 743720007003 DNA binding residues [nucleotide binding] 743720007004 dimer interface [polypeptide binding]; other site 743720007005 putative metal binding site [ion binding]; other site 743720007006 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 743720007007 Glutaredoxin; Region: Glutaredoxin; pfam00462 743720007008 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 743720007009 universal stress protein UspE; Provisional; Region: PRK11175 743720007010 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 743720007011 Ligand Binding Site [chemical binding]; other site 743720007012 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 743720007013 Ligand Binding Site [chemical binding]; other site 743720007014 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 743720007015 active site 743720007016 dinuclear metal binding site [ion binding]; other site 743720007017 dimerization interface [polypeptide binding]; other site 743720007018 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 743720007019 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 743720007020 putative active site [active] 743720007021 putative metal binding site [ion binding]; other site 743720007022 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 743720007023 substrate binding site [chemical binding]; other site 743720007024 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 743720007025 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 743720007026 active site 743720007027 HIGH motif; other site 743720007028 nucleotide binding site [chemical binding]; other site 743720007029 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 743720007030 KMSKS motif; other site 743720007031 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 743720007032 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 743720007033 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 743720007034 active site 743720007035 HIGH motif; other site 743720007036 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 743720007037 KMSKS motif; other site 743720007038 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 743720007039 tRNA binding surface [nucleotide binding]; other site 743720007040 anticodon binding site; other site 743720007041 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 743720007042 Family description; Region: UvrD_C_2; pfam13538 743720007043 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 743720007044 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 743720007045 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 743720007046 homodimer interface [polypeptide binding]; other site 743720007047 NADP binding site [chemical binding]; other site 743720007048 substrate binding site [chemical binding]; other site 743720007049 trigger factor; Provisional; Region: tig; PRK01490 743720007050 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 743720007051 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 743720007052 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 743720007053 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 743720007054 oligomer interface [polypeptide binding]; other site 743720007055 active site residues [active] 743720007056 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 743720007057 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 743720007058 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720007059 Walker A motif; other site 743720007060 ATP binding site [chemical binding]; other site 743720007061 Walker B motif; other site 743720007062 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 743720007063 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 743720007064 Found in ATP-dependent protease La (LON); Region: LON; smart00464 743720007065 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720007066 Walker A motif; other site 743720007067 ATP binding site [chemical binding]; other site 743720007068 Walker B motif; other site 743720007069 arginine finger; other site 743720007070 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 743720007071 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 743720007072 IHF dimer interface [polypeptide binding]; other site 743720007073 IHF - DNA interface [nucleotide binding]; other site 743720007074 periplasmic folding chaperone; Provisional; Region: PRK10788 743720007075 SurA N-terminal domain; Region: SurA_N_3; pfam13624 743720007076 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 743720007077 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 743720007078 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 743720007079 Walker A/P-loop; other site 743720007080 ATP binding site [chemical binding]; other site 743720007081 Q-loop/lid; other site 743720007082 ABC transporter signature motif; other site 743720007083 Walker B; other site 743720007084 D-loop; other site 743720007085 H-loop/switch region; other site 743720007086 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 743720007087 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 743720007088 Walker A/P-loop; other site 743720007089 ATP binding site [chemical binding]; other site 743720007090 Q-loop/lid; other site 743720007091 ABC transporter signature motif; other site 743720007092 Walker B; other site 743720007093 D-loop; other site 743720007094 H-loop/switch region; other site 743720007095 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 743720007096 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 743720007097 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720007098 dimer interface [polypeptide binding]; other site 743720007099 conserved gate region; other site 743720007100 putative PBP binding loops; other site 743720007101 ABC-ATPase subunit interface; other site 743720007102 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 743720007103 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720007104 dimer interface [polypeptide binding]; other site 743720007105 conserved gate region; other site 743720007106 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 743720007107 ABC-ATPase subunit interface; other site 743720007108 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 743720007109 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 743720007110 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 743720007111 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 743720007112 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 743720007113 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 743720007114 N-acetyl-D-glucosamine binding site [chemical binding]; other site 743720007115 catalytic residue [active] 743720007116 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 743720007117 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 743720007118 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 743720007119 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 743720007120 Methyltransferase domain; Region: Methyltransf_11; pfam08241 743720007121 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 743720007122 RNA/DNA hybrid binding site [nucleotide binding]; other site 743720007123 active site 743720007124 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 743720007125 active site 743720007126 catalytic site [active] 743720007127 substrate binding site [chemical binding]; other site 743720007128 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 743720007129 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 743720007130 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 743720007131 homodimer interface [polypeptide binding]; other site 743720007132 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720007133 catalytic residue [active] 743720007134 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 743720007135 enoyl-CoA hydratase; Provisional; Region: PRK06142 743720007136 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 743720007137 substrate binding site [chemical binding]; other site 743720007138 oxyanion hole (OAH) forming residues; other site 743720007139 trimer interface [polypeptide binding]; other site 743720007140 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 743720007141 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 743720007142 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 743720007143 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 743720007144 putative NADH binding site [chemical binding]; other site 743720007145 putative active site [active] 743720007146 nudix motif; other site 743720007147 putative metal binding site [ion binding]; other site 743720007148 hypothetical protein; Provisional; Region: PRK10621 743720007149 Predicted permeases [General function prediction only]; Region: COG0730 743720007150 short chain dehydrogenase; Provisional; Region: PRK07035 743720007151 classical (c) SDRs; Region: SDR_c; cd05233 743720007152 NAD(P) binding site [chemical binding]; other site 743720007153 active site 743720007154 Phosphotransferase enzyme family; Region: APH; pfam01636 743720007155 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 743720007156 putative active site [active] 743720007157 putative substrate binding site [chemical binding]; other site 743720007158 ATP binding site [chemical binding]; other site 743720007159 SCP-2 sterol transfer family; Region: SCP2; pfam02036 743720007160 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 743720007161 catalytic core [active] 743720007162 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 743720007163 putative inner membrane peptidase; Provisional; Region: PRK11778 743720007164 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 743720007165 tandem repeat interface [polypeptide binding]; other site 743720007166 oligomer interface [polypeptide binding]; other site 743720007167 active site residues [active] 743720007168 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 743720007169 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 743720007170 NADP binding site [chemical binding]; other site 743720007171 dimer interface [polypeptide binding]; other site 743720007172 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 743720007173 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 743720007174 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 743720007175 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 743720007176 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 743720007177 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 743720007178 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720007179 substrate binding pocket [chemical binding]; other site 743720007180 membrane-bound complex binding site; other site 743720007181 hinge residues; other site 743720007182 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 743720007183 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 743720007184 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 743720007185 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 743720007186 substrate binding pocket [chemical binding]; other site 743720007187 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 743720007188 B12 binding site [chemical binding]; other site 743720007189 cobalt ligand [ion binding]; other site 743720007190 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 743720007191 Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934 743720007192 Acyltransferase family; Region: Acyl_transf_3; pfam01757 743720007193 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 743720007194 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 743720007195 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 743720007196 Response regulator receiver domain; Region: Response_reg; pfam00072 743720007197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720007198 active site 743720007199 phosphorylation site [posttranslational modification] 743720007200 intermolecular recognition site; other site 743720007201 dimerization interface [polypeptide binding]; other site 743720007202 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 743720007203 PAS domain; Region: PAS; smart00091 743720007204 PAS fold; Region: PAS; pfam00989 743720007205 putative active site [active] 743720007206 heme pocket [chemical binding]; other site 743720007207 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743720007208 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720007209 metal binding site [ion binding]; metal-binding site 743720007210 active site 743720007211 I-site; other site 743720007212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720007213 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 743720007214 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 743720007215 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 743720007216 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 743720007217 conserved cys residue [active] 743720007218 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720007219 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 743720007220 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 743720007221 active site 743720007222 DNA binding site [nucleotide binding] 743720007223 Int/Topo IB signature motif; other site 743720007224 catalytic residues [active] 743720007225 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 743720007226 Predicted membrane protein [Function unknown]; Region: COG3212 743720007227 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 743720007228 Predicted membrane protein [Function unknown]; Region: COG3212 743720007229 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 743720007230 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720007231 active site 743720007232 phosphorylation site [posttranslational modification] 743720007233 intermolecular recognition site; other site 743720007234 dimerization interface [polypeptide binding]; other site 743720007235 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743720007236 DNA binding site [nucleotide binding] 743720007237 sensor protein PhoQ; Provisional; Region: PRK10815 743720007238 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720007239 ATP binding site [chemical binding]; other site 743720007240 G-X-G motif; other site 743720007241 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 743720007242 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 743720007243 Predicted permease [General function prediction only]; Region: COG2056 743720007244 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 743720007245 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 743720007246 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720007247 dimerization interface [polypeptide binding]; other site 743720007248 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720007249 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720007250 dimer interface [polypeptide binding]; other site 743720007251 putative CheW interface [polypeptide binding]; other site 743720007252 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 743720007253 Domain of unknown function DUF20; Region: UPF0118; pfam01594 743720007254 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 743720007255 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 743720007256 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 743720007257 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 743720007258 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 743720007259 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 743720007260 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 743720007261 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 743720007262 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 743720007263 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 743720007264 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 743720007265 4Fe-4S binding domain; Region: Fer4; pfam00037 743720007266 4Fe-4S binding domain; Region: Fer4; pfam00037 743720007267 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 743720007268 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 743720007269 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 743720007270 catalytic loop [active] 743720007271 iron binding site [ion binding]; other site 743720007272 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 743720007273 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 743720007274 [4Fe-4S] binding site [ion binding]; other site 743720007275 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 743720007276 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 743720007277 SLBB domain; Region: SLBB; pfam10531 743720007278 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 743720007279 NADH dehydrogenase subunit E; Validated; Region: PRK07539 743720007280 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 743720007281 putative dimer interface [polypeptide binding]; other site 743720007282 [2Fe-2S] cluster binding site [ion binding]; other site 743720007283 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 743720007284 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 743720007285 NADH dehydrogenase subunit D; Validated; Region: PRK06075 743720007286 NADH dehydrogenase subunit B; Validated; Region: PRK06411 743720007287 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 743720007288 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 743720007289 tetramer interface [polypeptide binding]; other site 743720007290 active site 743720007291 Mg2+/Mn2+ binding site [ion binding]; other site 743720007292 isocitrate lyase; Region: PLN02892 743720007293 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 743720007294 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 743720007295 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 743720007296 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720007297 Coenzyme A binding pocket [chemical binding]; other site 743720007298 Uncharacterized conserved protein [Function unknown]; Region: COG2850 743720007299 Cupin-like domain; Region: Cupin_8; pfam13621 743720007300 adenylosuccinate lyase; Provisional; Region: PRK09285 743720007301 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 743720007302 tetramer interface [polypeptide binding]; other site 743720007303 active site 743720007304 putative lysogenization regulator; Reviewed; Region: PRK00218 743720007305 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 743720007306 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 743720007307 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 743720007308 nudix motif; other site 743720007309 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 743720007310 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 743720007311 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 743720007312 DNA-binding site [nucleotide binding]; DNA binding site 743720007313 RNA-binding motif; other site 743720007314 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 743720007315 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 743720007316 Clp amino terminal domain; Region: Clp_N; pfam02861 743720007317 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720007318 Walker A motif; other site 743720007319 ATP binding site [chemical binding]; other site 743720007320 Walker B motif; other site 743720007321 arginine finger; other site 743720007322 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720007323 Walker A motif; other site 743720007324 ATP binding site [chemical binding]; other site 743720007325 Walker B motif; other site 743720007326 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 743720007327 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 743720007328 rRNA binding site [nucleotide binding]; other site 743720007329 predicted 30S ribosome binding site; other site 743720007330 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 743720007331 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 743720007332 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 743720007333 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 743720007334 thioredoxin reductase; Provisional; Region: PRK10262 743720007335 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 743720007336 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743720007337 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 743720007338 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 743720007339 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 743720007340 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 743720007341 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 743720007342 recombination factor protein RarA; Reviewed; Region: PRK13342 743720007343 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720007344 Walker A motif; other site 743720007345 ATP binding site [chemical binding]; other site 743720007346 Walker B motif; other site 743720007347 arginine finger; other site 743720007348 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 743720007349 camphor resistance protein CrcB; Provisional; Region: PRK14234 743720007350 seryl-tRNA synthetase; Provisional; Region: PRK05431 743720007351 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 743720007352 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 743720007353 dimer interface [polypeptide binding]; other site 743720007354 active site 743720007355 motif 1; other site 743720007356 motif 2; other site 743720007357 motif 3; other site 743720007358 siroheme synthase; Provisional; Region: cysG; PRK10637 743720007359 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 743720007360 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 743720007361 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 743720007362 active site 743720007363 SAM binding site [chemical binding]; other site 743720007364 homodimer interface [polypeptide binding]; other site 743720007365 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 743720007366 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 743720007367 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 743720007368 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 743720007369 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 743720007370 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 743720007371 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 743720007372 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 743720007373 HlyD family secretion protein; Region: HlyD_3; pfam13437 743720007374 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 743720007375 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 743720007376 NAD(P) binding site [chemical binding]; other site 743720007377 catalytic residues [active] 743720007378 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 743720007379 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 743720007380 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720007381 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 743720007382 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 743720007383 NAD(P) binding site [chemical binding]; other site 743720007384 catalytic residues [active] 743720007385 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 743720007386 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 743720007387 dimer interface [polypeptide binding]; other site 743720007388 active site 743720007389 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 743720007390 substrate binding site [chemical binding]; other site 743720007391 catalytic residue [active] 743720007392 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 743720007393 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 743720007394 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 743720007395 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 743720007396 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 743720007397 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805 743720007398 N- and C-terminal domain interface [polypeptide binding]; other site 743720007399 active site 743720007400 MgATP binding site [chemical binding]; other site 743720007401 catalytic site [active] 743720007402 metal binding site [ion binding]; metal-binding site 743720007403 xylulose binding site [chemical binding]; other site 743720007404 putative homodimer interface [polypeptide binding]; other site 743720007405 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 743720007406 intersubunit interface [polypeptide binding]; other site 743720007407 active site 743720007408 Zn2+ binding site [ion binding]; other site 743720007409 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 743720007410 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 743720007411 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 743720007412 inhibitor-cofactor binding pocket; inhibition site 743720007413 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720007414 catalytic residue [active] 743720007415 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 743720007416 short chain dehydrogenase; Provisional; Region: PRK06181 743720007417 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720007418 NAD(P) binding site [chemical binding]; other site 743720007419 active site 743720007420 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 743720007421 SurA N-terminal domain; Region: SurA_N; pfam09312 743720007422 Helix-turn-helix domain; Region: HTH_18; pfam12833 743720007423 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720007424 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 743720007425 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 743720007426 classical (c) SDRs; Region: SDR_c; cd05233 743720007427 NAD(P) binding site [chemical binding]; other site 743720007428 active site 743720007429 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720007430 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720007431 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 743720007432 putative substrate binding pocket [chemical binding]; other site 743720007433 putative dimerization interface [polypeptide binding]; other site 743720007434 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 743720007435 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 743720007436 putative NAD(P) binding site [chemical binding]; other site 743720007437 Transcriptional regulators [Transcription]; Region: PurR; COG1609 743720007438 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 743720007439 DNA binding site [nucleotide binding] 743720007440 domain linker motif; other site 743720007441 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 743720007442 putative ligand binding site [chemical binding]; other site 743720007443 putative dimerization interface [polypeptide binding]; other site 743720007444 AAA domain; Region: AAA_33; pfam13671 743720007445 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 743720007446 ATP-binding site [chemical binding]; other site 743720007447 Gluconate-6-phosphate binding site [chemical binding]; other site 743720007448 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 743720007449 fructuronate transporter; Provisional; Region: PRK10034; cl15264 743720007450 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 743720007451 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 743720007452 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 743720007453 Zn2+ binding site [ion binding]; other site 743720007454 Mg2+ binding site [ion binding]; other site 743720007455 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 743720007456 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 743720007457 DNA binding residues [nucleotide binding] 743720007458 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 743720007459 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 743720007460 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 743720007461 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 743720007462 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 743720007463 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 743720007464 WHG domain; Region: WHG; pfam13305 743720007465 enoyl-CoA hydratase; Provisional; Region: PRK06142 743720007466 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 743720007467 substrate binding site [chemical binding]; other site 743720007468 oxyanion hole (OAH) forming residues; other site 743720007469 trimer interface [polypeptide binding]; other site 743720007470 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 743720007471 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 743720007472 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 743720007473 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 743720007474 FAD binding pocket [chemical binding]; other site 743720007475 FAD binding motif [chemical binding]; other site 743720007476 phosphate binding motif [ion binding]; other site 743720007477 beta-alpha-beta structure motif; other site 743720007478 NAD binding pocket [chemical binding]; other site 743720007479 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 743720007480 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 743720007481 catalytic loop [active] 743720007482 iron binding site [ion binding]; other site 743720007483 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 743720007484 AMIN domain; Region: AMIN; pfam11741 743720007485 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 743720007486 active site 743720007487 metal binding site [ion binding]; metal-binding site 743720007488 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 743720007489 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 743720007490 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 743720007491 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 743720007492 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 743720007493 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 743720007494 Walker A/P-loop; other site 743720007495 ATP binding site [chemical binding]; other site 743720007496 Q-loop/lid; other site 743720007497 ABC transporter signature motif; other site 743720007498 Walker B; other site 743720007499 D-loop; other site 743720007500 H-loop/switch region; other site 743720007501 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 743720007502 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 743720007503 dimer interface [polypeptide binding]; other site 743720007504 putative PBP binding regions; other site 743720007505 ABC-ATPase subunit interface; other site 743720007506 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 743720007507 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 743720007508 ABC-ATPase subunit interface; other site 743720007509 dimer interface [polypeptide binding]; other site 743720007510 putative PBP binding regions; other site 743720007511 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 743720007512 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 743720007513 siderophore binding site; other site 743720007514 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 743720007515 IucA / IucC family; Region: IucA_IucC; pfam04183 743720007516 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 743720007517 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 743720007518 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 743720007519 IucA / IucC family; Region: IucA_IucC; pfam04183 743720007520 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 743720007521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720007522 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 743720007523 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 743720007524 dimer interface [polypeptide binding]; other site 743720007525 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 743720007526 active site 743720007527 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 743720007528 catalytic residues [active] 743720007529 substrate binding site [chemical binding]; other site 743720007530 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 743720007531 IucA / IucC family; Region: IucA_IucC; pfam04183 743720007532 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 743720007533 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 743720007534 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 743720007535 inhibitor-cofactor binding pocket; inhibition site 743720007536 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720007537 catalytic residue [active] 743720007538 Secretin and TonB N terminus short domain; Region: STN; smart00965 743720007539 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 743720007540 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743720007541 N-terminal plug; other site 743720007542 ligand-binding site [chemical binding]; other site 743720007543 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 743720007544 FecR protein; Region: FecR; pfam04773 743720007545 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 743720007546 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743720007547 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743720007548 DNA binding residues [nucleotide binding] 743720007549 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 743720007550 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 743720007551 substrate binding pocket [chemical binding]; other site 743720007552 chain length determination region; other site 743720007553 substrate-Mg2+ binding site; other site 743720007554 catalytic residues [active] 743720007555 aspartate-rich region 1; other site 743720007556 active site lid residues [active] 743720007557 aspartate-rich region 2; other site 743720007558 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 743720007559 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 743720007560 homotetramer interface [polypeptide binding]; other site 743720007561 FMN binding site [chemical binding]; other site 743720007562 homodimer contacts [polypeptide binding]; other site 743720007563 putative active site [active] 743720007564 putative substrate binding site [chemical binding]; other site 743720007565 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 743720007566 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 743720007567 active site 743720007568 TDP-binding site; other site 743720007569 acceptor substrate-binding pocket; other site 743720007570 homodimer interface [polypeptide binding]; other site 743720007571 Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834 743720007572 lycopene cyclase; Region: lycopene_cycl; TIGR01789 743720007573 phytoene desaturase; Region: crtI_fam; TIGR02734 743720007574 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 743720007575 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 743720007576 active site lid residues [active] 743720007577 substrate binding pocket [chemical binding]; other site 743720007578 catalytic residues [active] 743720007579 substrate-Mg2+ binding site; other site 743720007580 aspartate-rich region 1; other site 743720007581 aspartate-rich region 2; other site 743720007582 beta-carotene hydroxylase; Region: PLN02601 743720007583 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 743720007584 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 743720007585 active site 743720007586 tetramer interface; other site 743720007587 Competence-damaged protein; Region: CinA; pfam02464 743720007588 hypothetical protein; Provisional; Region: PRK09126 743720007589 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 743720007590 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 743720007591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720007592 dimer interface [polypeptide binding]; other site 743720007593 conserved gate region; other site 743720007594 putative PBP binding loops; other site 743720007595 ABC-ATPase subunit interface; other site 743720007596 sulfate transport protein; Provisional; Region: cysT; CHL00187 743720007597 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720007598 dimer interface [polypeptide binding]; other site 743720007599 conserved gate region; other site 743720007600 putative PBP binding loops; other site 743720007601 ABC-ATPase subunit interface; other site 743720007602 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 743720007603 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 743720007604 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 743720007605 NMT1-like family; Region: NMT1_2; pfam13379 743720007606 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 743720007607 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 743720007608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720007609 putative PBP binding loops; other site 743720007610 ABC-ATPase subunit interface; other site 743720007611 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 743720007612 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 743720007613 Walker A/P-loop; other site 743720007614 ATP binding site [chemical binding]; other site 743720007615 Q-loop/lid; other site 743720007616 ABC transporter signature motif; other site 743720007617 Walker B; other site 743720007618 D-loop; other site 743720007619 H-loop/switch region; other site 743720007620 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 743720007621 NMT1-like family; Region: NMT1_2; pfam13379 743720007622 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 743720007623 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 743720007624 active site 743720007625 iron coordination sites [ion binding]; other site 743720007626 substrate binding pocket [chemical binding]; other site 743720007627 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 743720007628 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 743720007629 D-cysteine desulfhydrase; Validated; Region: PRK03910 743720007630 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 743720007631 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 743720007632 catalytic residue [active] 743720007633 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 743720007634 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720007635 substrate binding pocket [chemical binding]; other site 743720007636 membrane-bound complex binding site; other site 743720007637 hinge residues; other site 743720007638 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 743720007639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720007640 dimer interface [polypeptide binding]; other site 743720007641 conserved gate region; other site 743720007642 putative PBP binding loops; other site 743720007643 ABC-ATPase subunit interface; other site 743720007644 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 743720007645 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 743720007646 Walker A/P-loop; other site 743720007647 ATP binding site [chemical binding]; other site 743720007648 Q-loop/lid; other site 743720007649 ABC transporter signature motif; other site 743720007650 Walker B; other site 743720007651 D-loop; other site 743720007652 H-loop/switch region; other site 743720007653 Predicted membrane protein [Function unknown]; Region: COG2860 743720007654 UPF0126 domain; Region: UPF0126; pfam03458 743720007655 UPF0126 domain; Region: UPF0126; pfam03458 743720007656 glutathione reductase; Validated; Region: PRK06116 743720007657 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 743720007658 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743720007659 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 743720007660 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 743720007661 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 743720007662 active site 743720007663 metal binding site [ion binding]; metal-binding site 743720007664 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 743720007665 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 743720007666 active site 743720007667 tetramer interface; other site 743720007668 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 743720007669 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 743720007670 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 743720007671 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 743720007672 Protein of unknown function (DUF1652); Region: DUF1652; pfam07865 743720007673 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 743720007674 Arc-like DNA binding domain; Region: Arc; pfam03869 743720007675 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 743720007676 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 743720007677 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 743720007678 GIY-YIG motif/motif A; other site 743720007679 active site 743720007680 catalytic site [active] 743720007681 putative DNA binding site [nucleotide binding]; other site 743720007682 metal binding site [ion binding]; metal-binding site 743720007683 UvrB/uvrC motif; Region: UVR; pfam02151 743720007684 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 743720007685 response regulator; Provisional; Region: PRK09483 743720007686 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720007687 active site 743720007688 phosphorylation site [posttranslational modification] 743720007689 intermolecular recognition site; other site 743720007690 dimerization interface [polypeptide binding]; other site 743720007691 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 743720007692 DNA binding residues [nucleotide binding] 743720007693 dimerization interface [polypeptide binding]; other site 743720007694 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 743720007695 YccA-like proteins; Region: YccA_like; cd10433 743720007696 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876 743720007697 putative lipid binding site [chemical binding]; other site 743720007698 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743720007699 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720007700 dimer interface [polypeptide binding]; other site 743720007701 phosphorylation site [posttranslational modification] 743720007702 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720007703 ATP binding site [chemical binding]; other site 743720007704 Mg2+ binding site [ion binding]; other site 743720007705 G-X-G motif; other site 743720007706 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 743720007707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720007708 active site 743720007709 phosphorylation site [posttranslational modification] 743720007710 intermolecular recognition site; other site 743720007711 dimerization interface [polypeptide binding]; other site 743720007712 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 743720007713 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743720007714 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720007715 metal binding site [ion binding]; metal-binding site 743720007716 active site 743720007717 I-site; other site 743720007718 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743720007719 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 743720007720 active site 743720007721 catalytic site [active] 743720007722 substrate binding site [chemical binding]; other site 743720007723 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 743720007724 Predicted Fe-S protein [General function prediction only]; Region: COG3313 743720007725 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 743720007726 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 743720007727 substrate binding site [chemical binding]; other site 743720007728 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 743720007729 substrate binding site [chemical binding]; other site 743720007730 ligand binding site [chemical binding]; other site 743720007731 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 743720007732 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 743720007733 catalytic residue [active] 743720007734 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 743720007735 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 743720007736 aminotransferase; Validated; Region: PRK08175 743720007737 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743720007738 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720007739 homodimer interface [polypeptide binding]; other site 743720007740 catalytic residue [active] 743720007741 PAS domain; Region: PAS; smart00091 743720007742 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 743720007743 putative active site [active] 743720007744 heme pocket [chemical binding]; other site 743720007745 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720007746 Walker B motif; other site 743720007747 arginine finger; other site 743720007748 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 743720007749 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 743720007750 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 743720007751 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720007752 NAD(P) binding site [chemical binding]; other site 743720007753 active site 743720007754 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 743720007755 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 743720007756 acyl-activating enzyme (AAE) consensus motif; other site 743720007757 putative AMP binding site [chemical binding]; other site 743720007758 putative active site [active] 743720007759 putative CoA binding site [chemical binding]; other site 743720007760 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720007761 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 743720007762 substrate binding pocket [chemical binding]; other site 743720007763 membrane-bound complex binding site; other site 743720007764 hinge residues; other site 743720007765 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 743720007766 Putative amidotransferase; Region: DUF4066; pfam13278 743720007767 conserved cys residue [active] 743720007768 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 743720007769 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 743720007770 Walker A motif; other site 743720007771 ATP binding site [chemical binding]; other site 743720007772 Walker B motif; other site 743720007773 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 743720007774 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 743720007775 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 743720007776 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 743720007777 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 743720007778 NADH dehydrogenase subunit L; Provisional; Region: PRK08168 743720007779 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 743720007780 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 743720007781 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720007782 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720007783 dimerization interface [polypeptide binding]; other site 743720007784 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 743720007785 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 743720007786 active site residue [active] 743720007787 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 743720007788 active site residue [active] 743720007789 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 743720007790 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 743720007791 Walker A/P-loop; other site 743720007792 ATP binding site [chemical binding]; other site 743720007793 Q-loop/lid; other site 743720007794 ABC transporter signature motif; other site 743720007795 Walker B; other site 743720007796 D-loop; other site 743720007797 H-loop/switch region; other site 743720007798 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 743720007799 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720007800 dimer interface [polypeptide binding]; other site 743720007801 conserved gate region; other site 743720007802 putative PBP binding loops; other site 743720007803 ABC-ATPase subunit interface; other site 743720007804 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 743720007805 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720007806 substrate binding pocket [chemical binding]; other site 743720007807 membrane-bound complex binding site; other site 743720007808 outer membrane porin, OprD family; Region: OprD; pfam03573 743720007809 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 743720007810 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720007811 substrate binding pocket [chemical binding]; other site 743720007812 membrane-bound complex binding site; other site 743720007813 hinge residues; other site 743720007814 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 743720007815 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 743720007816 Flavin binding site [chemical binding]; other site 743720007817 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 743720007818 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 743720007819 active site 743720007820 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 743720007821 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 743720007822 active site 743720007823 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 743720007824 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 743720007825 active site 743720007826 non-prolyl cis peptide bond; other site 743720007827 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 743720007828 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 743720007829 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 743720007830 Walker A/P-loop; other site 743720007831 ATP binding site [chemical binding]; other site 743720007832 Q-loop/lid; other site 743720007833 ABC transporter signature motif; other site 743720007834 Walker B; other site 743720007835 D-loop; other site 743720007836 H-loop/switch region; other site 743720007837 NIL domain; Region: NIL; pfam09383 743720007838 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720007839 dimer interface [polypeptide binding]; other site 743720007840 conserved gate region; other site 743720007841 ABC-ATPase subunit interface; other site 743720007842 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 743720007843 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 743720007844 active site 743720007845 non-prolyl cis peptide bond; other site 743720007846 Cupin; Region: Cupin_6; pfam12852 743720007847 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720007848 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 743720007849 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720007850 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 743720007851 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 743720007852 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 743720007853 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743720007854 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720007855 metal binding site [ion binding]; metal-binding site 743720007856 active site 743720007857 I-site; other site 743720007858 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 743720007859 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 743720007860 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 743720007861 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743720007862 Walker A/P-loop; other site 743720007863 ATP binding site [chemical binding]; other site 743720007864 ABC transporter signature motif; other site 743720007865 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 743720007866 Walker B; other site 743720007867 ABC transporter; Region: ABC_tran_2; pfam12848 743720007868 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 743720007869 heat shock protein 90; Provisional; Region: PRK05218 743720007870 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720007871 ATP binding site [chemical binding]; other site 743720007872 Mg2+ binding site [ion binding]; other site 743720007873 G-X-G motif; other site 743720007874 Predicted membrane protein [Function unknown]; Region: COG3686 743720007875 Predicted membrane protein [Function unknown]; Region: COG3821 743720007876 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 743720007877 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 743720007878 CoA binding domain; Region: CoA_binding; pfam02629 743720007879 CoA-ligase; Region: Ligase_CoA; pfam00549 743720007880 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 743720007881 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 743720007882 CoA-ligase; Region: Ligase_CoA; pfam00549 743720007883 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 743720007884 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 743720007885 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743720007886 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 743720007887 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 743720007888 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 743720007889 E3 interaction surface; other site 743720007890 lipoyl attachment site [posttranslational modification]; other site 743720007891 e3 binding domain; Region: E3_binding; pfam02817 743720007892 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 743720007893 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 743720007894 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 743720007895 TPP-binding site [chemical binding]; other site 743720007896 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 743720007897 dimer interface [polypeptide binding]; other site 743720007898 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 743720007899 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 743720007900 L-aspartate oxidase; Provisional; Region: PRK06175 743720007901 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05675 743720007902 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 743720007903 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 743720007904 SdhC subunit interface [polypeptide binding]; other site 743720007905 proximal heme binding site [chemical binding]; other site 743720007906 cardiolipin binding site; other site 743720007907 Iron-sulfur protein interface; other site 743720007908 proximal quinone binding site [chemical binding]; other site 743720007909 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 743720007910 Iron-sulfur protein interface; other site 743720007911 proximal quinone binding site [chemical binding]; other site 743720007912 SdhD (CybS) interface [polypeptide binding]; other site 743720007913 proximal heme binding site [chemical binding]; other site 743720007914 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 743720007915 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 743720007916 dimer interface [polypeptide binding]; other site 743720007917 active site 743720007918 citrylCoA binding site [chemical binding]; other site 743720007919 NADH binding [chemical binding]; other site 743720007920 cationic pore residues; other site 743720007921 oxalacetate/citrate binding site [chemical binding]; other site 743720007922 coenzyme A binding site [chemical binding]; other site 743720007923 catalytic triad [active] 743720007924 DsrE/DsrF-like family; Region: DrsE; cl00672 743720007925 sulfur relay protein TusC; Validated; Region: PRK00211 743720007926 DsrH like protein; Region: DsrH; cl17347 743720007927 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 743720007928 DsrC like protein; Region: DsrC; cl01101 743720007929 hypothetical protein; Validated; Region: PRK09071 743720007930 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 743720007931 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 743720007932 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 743720007933 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 743720007934 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 743720007935 putative dimer interface [polypeptide binding]; other site 743720007936 N-terminal domain interface [polypeptide binding]; other site 743720007937 putative substrate binding pocket (H-site) [chemical binding]; other site 743720007938 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 743720007939 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 743720007940 Protein export membrane protein; Region: SecD_SecF; cl14618 743720007941 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 743720007942 Protein export membrane protein; Region: SecD_SecF; cl14618 743720007943 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 743720007944 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 743720007945 HlyD family secretion protein; Region: HlyD_3; pfam13437 743720007946 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 743720007947 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 743720007948 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 743720007949 dihydroxy-acid dehydratase; Validated; Region: PRK06131 743720007950 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 743720007951 classical (c) SDRs; Region: SDR_c; cd05233 743720007952 NAD(P) binding site [chemical binding]; other site 743720007953 active site 743720007954 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 743720007955 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 743720007956 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 743720007957 TM-ABC transporter signature motif; other site 743720007958 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 743720007959 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 743720007960 Walker A/P-loop; other site 743720007961 ATP binding site [chemical binding]; other site 743720007962 Q-loop/lid; other site 743720007963 ABC transporter signature motif; other site 743720007964 Walker B; other site 743720007965 D-loop; other site 743720007966 H-loop/switch region; other site 743720007967 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 743720007968 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 743720007969 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 743720007970 putative ligand binding site [chemical binding]; other site 743720007971 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720007972 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720007973 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720007974 dimerization interface [polypeptide binding]; other site 743720007975 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 743720007976 dimer interface [polypeptide binding]; other site 743720007977 catalytic triad [active] 743720007978 peroxidatic and resolving cysteines [active] 743720007979 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 743720007980 Family of unknown function (DUF490); Region: DUF490; pfam04357 743720007981 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 743720007982 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 743720007983 Surface antigen; Region: Bac_surface_Ag; pfam01103 743720007984 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 743720007985 putative catalytic site [active] 743720007986 putative phosphate binding site [ion binding]; other site 743720007987 active site 743720007988 metal binding site A [ion binding]; metal-binding site 743720007989 DNA binding site [nucleotide binding] 743720007990 putative AP binding site [nucleotide binding]; other site 743720007991 putative metal binding site B [ion binding]; other site 743720007992 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 743720007993 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 743720007994 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 743720007995 ligand binding site [chemical binding]; other site 743720007996 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 743720007997 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 743720007998 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 743720007999 FAD binding site [chemical binding]; other site 743720008000 substrate binding site [chemical binding]; other site 743720008001 catalytic base [active] 743720008002 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 743720008003 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720008004 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 743720008005 substrate binding pocket [chemical binding]; other site 743720008006 dimerization interface [polypeptide binding]; other site 743720008007 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 743720008008 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 743720008009 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 743720008010 ligand binding site [chemical binding]; other site 743720008011 RNA polymerase sigma factor SigX; Reviewed; Region: PRK09640 743720008012 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743720008013 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743720008014 DNA binding residues [nucleotide binding] 743720008015 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 743720008016 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 743720008017 Cl binding site [ion binding]; other site 743720008018 oligomer interface [polypeptide binding]; other site 743720008019 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 743720008020 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 743720008021 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 743720008022 phosphoenolpyruvate synthase; Validated; Region: PRK06464 743720008023 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 743720008024 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 743720008025 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 743720008026 PEP synthetase regulatory protein; Provisional; Region: PRK05339 743720008027 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 743720008028 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 743720008029 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 743720008030 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 743720008031 substrate binding site [chemical binding]; other site 743720008032 ligand binding site [chemical binding]; other site 743720008033 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 743720008034 substrate binding site [chemical binding]; other site 743720008035 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 743720008036 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 743720008037 dimer interface [polypeptide binding]; other site 743720008038 active site 743720008039 citrylCoA binding site [chemical binding]; other site 743720008040 oxalacetate/citrate binding site [chemical binding]; other site 743720008041 coenzyme A binding site [chemical binding]; other site 743720008042 catalytic triad [active] 743720008043 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 743720008044 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 743720008045 tetramer interface [polypeptide binding]; other site 743720008046 active site 743720008047 Mg2+/Mn2+ binding site [ion binding]; other site 743720008048 Transcriptional regulators [Transcription]; Region: GntR; COG1802 743720008049 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720008050 DNA-binding site [nucleotide binding]; DNA binding site 743720008051 FCD domain; Region: FCD; pfam07729 743720008052 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 743720008053 Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400 743720008054 7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402 743720008055 alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291 743720008056 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 743720008057 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 743720008058 Active Sites [active] 743720008059 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 743720008060 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720008061 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 743720008062 substrate binding site [chemical binding]; other site 743720008063 dimerization interface [polypeptide binding]; other site 743720008064 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 743720008065 Ligand Binding Site [chemical binding]; other site 743720008066 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 743720008067 catalytic residues [active] 743720008068 PilZ domain; Region: PilZ; pfam07238 743720008069 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 743720008070 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 743720008071 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720008072 Coenzyme A binding pocket [chemical binding]; other site 743720008073 L,D-transpeptidase; Provisional; Region: PRK10260 743720008074 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 743720008075 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 743720008076 active site 743720008077 catalytic triad [active] 743720008078 oxyanion hole [active] 743720008079 switch loop; other site 743720008080 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 743720008081 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 743720008082 Walker A/P-loop; other site 743720008083 ATP binding site [chemical binding]; other site 743720008084 Q-loop/lid; other site 743720008085 ABC transporter signature motif; other site 743720008086 Walker B; other site 743720008087 D-loop; other site 743720008088 H-loop/switch region; other site 743720008089 FtsX-like permease family; Region: FtsX; pfam02687 743720008090 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 743720008091 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 743720008092 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 743720008093 Predicted membrane protein [Function unknown]; Region: COG2259 743720008094 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 743720008095 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720008096 dimerization interface [polypeptide binding]; other site 743720008097 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 743720008098 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 743720008099 N-acetyl-D-glucosamine binding site [chemical binding]; other site 743720008100 catalytic residue [active] 743720008101 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 743720008102 active site 743720008103 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720008104 dimerization interface [polypeptide binding]; other site 743720008105 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720008106 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720008107 dimer interface [polypeptide binding]; other site 743720008108 putative CheW interface [polypeptide binding]; other site 743720008109 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 743720008110 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 743720008111 active site 743720008112 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 743720008113 active site 2 [active] 743720008114 active site 1 [active] 743720008115 CHAD domain; Region: CHAD; pfam05235 743720008116 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 743720008117 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 743720008118 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 743720008119 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 743720008120 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 743720008121 Protein of unknown function DUF58; Region: DUF58; pfam01882 743720008122 MoxR-like ATPases [General function prediction only]; Region: COG0714 743720008123 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720008124 Walker A motif; other site 743720008125 ATP binding site [chemical binding]; other site 743720008126 Walker B motif; other site 743720008127 arginine finger; other site 743720008128 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720008129 dimerization interface [polypeptide binding]; other site 743720008130 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720008131 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720008132 dimer interface [polypeptide binding]; other site 743720008133 putative CheW interface [polypeptide binding]; other site 743720008134 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 743720008135 hypothetical protein; Provisional; Region: PRK10279 743720008136 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 743720008137 active site 743720008138 nucleophile elbow; other site 743720008139 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 743720008140 Domain of unknown function DUF20; Region: UPF0118; pfam01594 743720008141 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 743720008142 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 743720008143 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 743720008144 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 743720008145 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 743720008146 CoenzymeA binding site [chemical binding]; other site 743720008147 subunit interaction site [polypeptide binding]; other site 743720008148 PHB binding site; other site 743720008149 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 743720008150 catalytic core [active] 743720008151 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 743720008152 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 743720008153 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 743720008154 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 743720008155 ABC transporter substrate binding protein; Region: ABC_sub_bind; cl17301 743720008156 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743720008157 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720008158 dimer interface [polypeptide binding]; other site 743720008159 phosphorylation site [posttranslational modification] 743720008160 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720008161 ATP binding site [chemical binding]; other site 743720008162 Mg2+ binding site [ion binding]; other site 743720008163 G-X-G motif; other site 743720008164 Response regulator receiver domain; Region: Response_reg; pfam00072 743720008165 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720008166 active site 743720008167 phosphorylation site [posttranslational modification] 743720008168 intermolecular recognition site; other site 743720008169 dimerization interface [polypeptide binding]; other site 743720008170 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 743720008171 active site 1 [active] 743720008172 dimer interface [polypeptide binding]; other site 743720008173 active site 2 [active] 743720008174 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 743720008175 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 743720008176 dimer interface [polypeptide binding]; other site 743720008177 active site 743720008178 Domain of unknown function (DUF3859); Region: DUF3859; pfam12975 743720008179 Amidohydrolase; Region: Amidohydro_2; pfam04909 743720008180 RNA polymerase sigma factor; Provisional; Region: PRK12537 743720008181 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743720008182 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743720008183 DNA binding residues [nucleotide binding] 743720008184 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 743720008185 Anti-sigma-K factor rskA; Region: RskA; pfam10099 743720008186 Domain of unknown function (DUF4394); Region: DUF4394; pfam14339 743720008187 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 743720008188 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 743720008189 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 743720008190 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 743720008191 LysR family transcriptional regulator; Provisional; Region: PRK14997 743720008192 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720008193 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720008194 dimerization interface [polypeptide binding]; other site 743720008195 major facilitator superfamily transporter; Provisional; Region: PRK05122 743720008196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720008197 putative substrate translocation pore; other site 743720008198 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 743720008199 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 743720008200 DNA-binding site [nucleotide binding]; DNA binding site 743720008201 RNA-binding motif; other site 743720008202 Predicted membrane protein [Function unknown]; Region: COG3326 743720008203 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 743720008204 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 743720008205 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 743720008206 AAA domain; Region: AAA_28; pfam13521 743720008207 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 743720008208 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 743720008209 putative heme binding pocket [chemical binding]; other site 743720008210 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 743720008211 active site 743720008212 Dehydroquinase class II; Region: DHquinase_II; pfam01220 743720008213 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 743720008214 trimer interface [polypeptide binding]; other site 743720008215 active site 743720008216 dimer interface [polypeptide binding]; other site 743720008217 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 743720008218 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 743720008219 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 743720008220 shikimate binding site; other site 743720008221 NAD(P) binding site [chemical binding]; other site 743720008222 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 743720008223 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 743720008224 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 743720008225 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 743720008226 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 743720008227 dimer interface [polypeptide binding]; other site 743720008228 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 743720008229 active site 743720008230 Fe binding site [ion binding]; other site 743720008231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720008232 metabolite-proton symporter; Region: 2A0106; TIGR00883 743720008233 putative substrate translocation pore; other site 743720008234 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 743720008235 EamA-like transporter family; Region: EamA; pfam00892 743720008236 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 743720008237 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 743720008238 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 743720008239 Transcriptional regulator [Transcription]; Region: IclR; COG1414 743720008240 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 743720008241 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 743720008242 Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970 743720008243 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 743720008244 outer membrane porin, OprD family; Region: OprD; pfam03573 743720008245 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 743720008246 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720008247 dimerization interface [polypeptide binding]; other site 743720008248 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720008249 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720008250 dimer interface [polypeptide binding]; other site 743720008251 putative CheW interface [polypeptide binding]; other site 743720008252 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 743720008253 IHF - DNA interface [nucleotide binding]; other site 743720008254 IHF dimer interface [polypeptide binding]; other site 743720008255 OPT oligopeptide transporter protein; Region: OPT; cl14607 743720008256 OPT oligopeptide transporter protein; Region: OPT; cl14607 743720008257 Ligase N family; Region: LIGANc; smart00532 743720008258 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 743720008259 nucleotide binding pocket [chemical binding]; other site 743720008260 K-X-D-G motif; other site 743720008261 catalytic site [active] 743720008262 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 743720008263 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 743720008264 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 743720008265 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 743720008266 Dimer interface [polypeptide binding]; other site 743720008267 Cell division protein [Cell division and chromosome partitioning]; Region: ZipA; COG3115 743720008268 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 743720008269 FtsZ protein binding site [polypeptide binding]; other site 743720008270 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 743720008271 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 743720008272 Walker A/P-loop; other site 743720008273 ATP binding site [chemical binding]; other site 743720008274 Q-loop/lid; other site 743720008275 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 743720008276 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 743720008277 ABC transporter signature motif; other site 743720008278 Walker B; other site 743720008279 D-loop; other site 743720008280 H-loop/switch region; other site 743720008281 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720008282 putative substrate translocation pore; other site 743720008283 guanine deaminase; Provisional; Region: PRK09228 743720008284 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 743720008285 active site 743720008286 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 743720008287 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 743720008288 Walker A/P-loop; other site 743720008289 ATP binding site [chemical binding]; other site 743720008290 Q-loop/lid; other site 743720008291 ABC transporter signature motif; other site 743720008292 Walker B; other site 743720008293 D-loop; other site 743720008294 H-loop/switch region; other site 743720008295 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 743720008296 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 743720008297 ABC-ATPase subunit interface; other site 743720008298 dimer interface [polypeptide binding]; other site 743720008299 putative PBP binding regions; other site 743720008300 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 743720008301 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 743720008302 intersubunit interface [polypeptide binding]; other site 743720008303 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 743720008304 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 743720008305 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743720008306 FeS/SAM binding site; other site 743720008307 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 743720008308 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 743720008309 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 743720008310 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 743720008311 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 743720008312 Cytochrome c; Region: Cytochrom_C; pfam00034 743720008313 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 743720008314 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 743720008315 D-pathway; other site 743720008316 Putative ubiquinol binding site [chemical binding]; other site 743720008317 Low-spin heme (heme b) binding site [chemical binding]; other site 743720008318 Putative water exit pathway; other site 743720008319 Binuclear center (heme o3/CuB) [ion binding]; other site 743720008320 K-pathway; other site 743720008321 Putative proton exit pathway; other site 743720008322 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 743720008323 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 743720008324 conserved cys residue [active] 743720008325 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720008326 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720008327 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 743720008328 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 743720008329 Walker A/P-loop; other site 743720008330 ATP binding site [chemical binding]; other site 743720008331 Q-loop/lid; other site 743720008332 ABC transporter signature motif; other site 743720008333 Walker B; other site 743720008334 D-loop; other site 743720008335 H-loop/switch region; other site 743720008336 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720008337 dimer interface [polypeptide binding]; other site 743720008338 conserved gate region; other site 743720008339 putative PBP binding loops; other site 743720008340 ABC-ATPase subunit interface; other site 743720008341 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 743720008342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720008343 dimer interface [polypeptide binding]; other site 743720008344 conserved gate region; other site 743720008345 putative PBP binding loops; other site 743720008346 ABC-ATPase subunit interface; other site 743720008347 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 743720008348 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720008349 substrate binding pocket [chemical binding]; other site 743720008350 membrane-bound complex binding site; other site 743720008351 hinge residues; other site 743720008352 acetyl-CoA synthetase; Provisional; Region: PRK00174 743720008353 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 743720008354 active site 743720008355 CoA binding site [chemical binding]; other site 743720008356 acyl-activating enzyme (AAE) consensus motif; other site 743720008357 AMP binding site [chemical binding]; other site 743720008358 acetate binding site [chemical binding]; other site 743720008359 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 743720008360 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743720008361 DctM-like transporters; Region: DctM; pfam06808 743720008362 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 743720008363 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 743720008364 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 743720008365 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 743720008366 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720008367 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720008368 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 743720008369 putative dimerization interface [polypeptide binding]; other site 743720008370 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 743720008371 CoA-transferase family III; Region: CoA_transf_3; pfam02515 743720008372 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 743720008373 active site 743720008374 catalytic residues [active] 743720008375 metal binding site [ion binding]; metal-binding site 743720008376 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 743720008377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720008378 putative substrate translocation pore; other site 743720008379 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720008380 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 743720008381 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 743720008382 HlyD family secretion protein; Region: HlyD_3; pfam13437 743720008383 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 743720008384 MarR family; Region: MarR_2; cl17246 743720008385 Transcriptional regulators [Transcription]; Region: MarR; COG1846 743720008386 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 743720008387 putative FMN binding site [chemical binding]; other site 743720008388 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 743720008389 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 743720008390 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 743720008391 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 743720008392 CoA-transferase family III; Region: CoA_transf_3; pfam02515 743720008393 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 743720008394 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 743720008395 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 743720008396 active site 743720008397 Uncharacterized conserved protein [Function unknown]; Region: COG3777 743720008398 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 743720008399 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 743720008400 active site 2 [active] 743720008401 active site 1 [active] 743720008402 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720008403 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720008404 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 743720008405 putative dimerization interface [polypeptide binding]; other site 743720008406 Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462 743720008407 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 743720008408 Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813 743720008409 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 743720008410 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 743720008411 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720008412 Walker A motif; other site 743720008413 ATP binding site [chemical binding]; other site 743720008414 Walker B motif; other site 743720008415 arginine finger; other site 743720008416 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 743720008417 cofactor binding site; other site 743720008418 metal binding site [ion binding]; metal-binding site 743720008419 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 743720008420 aromatic arch; other site 743720008421 DCoH dimer interaction site [polypeptide binding]; other site 743720008422 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 743720008423 DCoH tetramer interaction site [polypeptide binding]; other site 743720008424 substrate binding site [chemical binding]; other site 743720008425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720008426 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720008427 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 743720008428 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743720008429 active site 743720008430 motif I; other site 743720008431 motif II; other site 743720008432 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 743720008433 glucosylglycerol-phosphate synthase; Region: gluc_glyc_Psyn; TIGR02398 743720008434 active site 743720008435 homotetramer interface [polypeptide binding]; other site 743720008436 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 743720008437 active site 743720008438 SAM binding site [chemical binding]; other site 743720008439 homodimer interface [polypeptide binding]; other site 743720008440 HemK family putative methylases; Region: hemK_fam; TIGR00536 743720008441 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720008442 S-adenosylmethionine binding site [chemical binding]; other site 743720008443 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 743720008444 Isochorismatase family; Region: Isochorismatase; pfam00857 743720008445 catalytic triad [active] 743720008446 conserved cis-peptide bond; other site 743720008447 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 743720008448 Smr domain; Region: Smr; pfam01713 743720008449 elongation factor P; Validated; Region: PRK00529 743720008450 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 743720008451 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 743720008452 RNA binding site [nucleotide binding]; other site 743720008453 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 743720008454 RNA binding site [nucleotide binding]; other site 743720008455 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 743720008456 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 743720008457 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720008458 putative substrate translocation pore; other site 743720008459 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 743720008460 catalytic core [active] 743720008461 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 743720008462 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 743720008463 substrate binding site [chemical binding]; other site 743720008464 oxyanion hole (OAH) forming residues; other site 743720008465 trimer interface [polypeptide binding]; other site 743720008466 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 743720008467 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 743720008468 oligomer interface [polypeptide binding]; other site 743720008469 metal binding site [ion binding]; metal-binding site 743720008470 metal binding site [ion binding]; metal-binding site 743720008471 putative Cl binding site [ion binding]; other site 743720008472 basic sphincter; other site 743720008473 hydrophobic gate; other site 743720008474 periplasmic entrance; other site 743720008475 inner membrane transport permease; Provisional; Region: PRK15066 743720008476 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 743720008477 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 743720008478 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 743720008479 Walker A/P-loop; other site 743720008480 ATP binding site [chemical binding]; other site 743720008481 Q-loop/lid; other site 743720008482 ABC transporter signature motif; other site 743720008483 Walker B; other site 743720008484 D-loop; other site 743720008485 H-loop/switch region; other site 743720008486 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 743720008487 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 743720008488 putative C-terminal domain interface [polypeptide binding]; other site 743720008489 putative GSH binding site (G-site) [chemical binding]; other site 743720008490 putative dimer interface [polypeptide binding]; other site 743720008491 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 743720008492 putative N-terminal domain interface [polypeptide binding]; other site 743720008493 putative dimer interface [polypeptide binding]; other site 743720008494 putative substrate binding pocket (H-site) [chemical binding]; other site 743720008495 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 743720008496 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 743720008497 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 743720008498 active site 743720008499 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 743720008500 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 743720008501 GAF domain; Region: GAF_2; pfam13185 743720008502 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 743720008503 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720008504 Walker A motif; other site 743720008505 ATP binding site [chemical binding]; other site 743720008506 Walker B motif; other site 743720008507 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 743720008508 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720008509 ATP binding site [chemical binding]; other site 743720008510 Mg2+ binding site [ion binding]; other site 743720008511 G-X-G motif; other site 743720008512 Response regulator receiver domain; Region: Response_reg; pfam00072 743720008513 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720008514 active site 743720008515 phosphorylation site [posttranslational modification] 743720008516 intermolecular recognition site; other site 743720008517 dimerization interface [polypeptide binding]; other site 743720008518 Transcriptional regulators [Transcription]; Region: MarR; COG1846 743720008519 MarR family; Region: MarR_2; cl17246 743720008520 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 743720008521 catalytic residues [active] 743720008522 dimer interface [polypeptide binding]; other site 743720008523 methionine sulfoxide reductase B; Provisional; Region: PRK00222 743720008524 SelR domain; Region: SelR; pfam01641 743720008525 aminotransferase AlaT; Validated; Region: PRK09265 743720008526 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743720008527 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720008528 homodimer interface [polypeptide binding]; other site 743720008529 catalytic residue [active] 743720008530 heat shock protein HtpX; Provisional; Region: PRK05457 743720008531 thiopurine S-methyltransferase; Reviewed; Region: PRK13255 743720008532 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 743720008533 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 743720008534 putative active site [active] 743720008535 metal binding site [ion binding]; metal-binding site 743720008536 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 743720008537 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 743720008538 chorismate binding enzyme; Region: Chorismate_bind; cl10555 743720008539 helicase 45; Provisional; Region: PTZ00424 743720008540 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 743720008541 ATP binding site [chemical binding]; other site 743720008542 Mg++ binding site [ion binding]; other site 743720008543 motif III; other site 743720008544 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743720008545 nucleotide binding region [chemical binding]; other site 743720008546 ATP-binding site [chemical binding]; other site 743720008547 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 743720008548 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 743720008549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720008550 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 743720008551 Protein of unknown function (DUF2897); Region: DUF2897; pfam11446 743720008552 CAAX protease self-immunity; Region: Abi; pfam02517 743720008553 RNA polymerase sigma factor; Provisional; Region: PRK12513 743720008554 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743720008555 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743720008556 DNA binding residues [nucleotide binding] 743720008557 von Willebrand factor; Region: vWF_A; pfam12450 743720008558 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 743720008559 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 743720008560 metal ion-dependent adhesion site (MIDAS); other site 743720008561 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 743720008562 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 743720008563 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720008564 DNA-binding site [nucleotide binding]; DNA binding site 743720008565 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743720008566 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720008567 homodimer interface [polypeptide binding]; other site 743720008568 catalytic residue [active] 743720008569 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 743720008570 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 743720008571 ligand binding site [chemical binding]; other site 743720008572 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 743720008573 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720008574 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 743720008575 substrate binding pocket [chemical binding]; other site 743720008576 membrane-bound complex binding site; other site 743720008577 hinge residues; other site 743720008578 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 743720008579 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 743720008580 nucleophilic elbow; other site 743720008581 catalytic triad; other site 743720008582 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 743720008583 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 743720008584 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 743720008585 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 743720008586 Ligand binding site [chemical binding]; other site 743720008587 Electron transfer flavoprotein domain; Region: ETF; pfam01012 743720008588 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 743720008589 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 743720008590 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 743720008591 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816 743720008592 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 743720008593 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 743720008594 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 743720008595 WHG domain; Region: WHG; pfam13305 743720008596 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 743720008597 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 743720008598 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 743720008599 catalytic residue [active] 743720008600 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 743720008601 active site 743720008602 PilZ domain; Region: PilZ; cl01260 743720008603 DNA polymerase III subunit delta'; Validated; Region: PRK05707 743720008604 DNA polymerase III subunit delta'; Validated; Region: PRK08485 743720008605 thymidylate kinase; Validated; Region: tmk; PRK00698 743720008606 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 743720008607 TMP-binding site; other site 743720008608 ATP-binding site [chemical binding]; other site 743720008609 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 743720008610 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 743720008611 dimerization interface [polypeptide binding]; other site 743720008612 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 743720008613 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 743720008614 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720008615 catalytic residue [active] 743720008616 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 743720008617 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 743720008618 dimer interface [polypeptide binding]; other site 743720008619 active site 743720008620 acyl carrier protein; Provisional; Region: acpP; PRK00982 743720008621 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 743720008622 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 743720008623 NAD(P) binding site [chemical binding]; other site 743720008624 homotetramer interface [polypeptide binding]; other site 743720008625 homodimer interface [polypeptide binding]; other site 743720008626 active site 743720008627 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 743720008628 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 743720008629 putative phosphate acyltransferase; Provisional; Region: PRK05331 743720008630 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 743720008631 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 743720008632 Maf-like protein; Region: Maf; pfam02545 743720008633 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 743720008634 active site 743720008635 dimer interface [polypeptide binding]; other site 743720008636 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 743720008637 AAA domain; Region: AAA_30; pfam13604 743720008638 Family description; Region: UvrD_C_2; pfam13538 743720008639 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 743720008640 Part of AAA domain; Region: AAA_19; pfam13245 743720008641 Family description; Region: UvrD_C_2; pfam13538 743720008642 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 743720008643 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 743720008644 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 743720008645 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 743720008646 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 743720008647 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 743720008648 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 743720008649 tetramer interface [polypeptide binding]; other site 743720008650 heme binding pocket [chemical binding]; other site 743720008651 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 743720008652 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 743720008653 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720008654 dimerization interface [polypeptide binding]; other site 743720008655 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720008656 dimer interface [polypeptide binding]; other site 743720008657 putative CheW interface [polypeptide binding]; other site 743720008658 Predicted membrane protein [Function unknown]; Region: COG2323 743720008659 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 743720008660 amino acid transporter; Region: 2A0306; TIGR00909 743720008661 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 743720008662 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 743720008663 DNA binding residues [nucleotide binding] 743720008664 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 743720008665 IHF dimer interface [polypeptide binding]; other site 743720008666 IHF - DNA interface [nucleotide binding]; other site 743720008667 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 743720008668 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 743720008669 putative tRNA-binding site [nucleotide binding]; other site 743720008670 B3/4 domain; Region: B3_4; pfam03483 743720008671 tRNA synthetase B5 domain; Region: B5; smart00874 743720008672 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 743720008673 dimer interface [polypeptide binding]; other site 743720008674 motif 1; other site 743720008675 motif 3; other site 743720008676 motif 2; other site 743720008677 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 743720008678 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 743720008679 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 743720008680 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 743720008681 dimer interface [polypeptide binding]; other site 743720008682 motif 1; other site 743720008683 active site 743720008684 motif 2; other site 743720008685 motif 3; other site 743720008686 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 743720008687 23S rRNA binding site [nucleotide binding]; other site 743720008688 L21 binding site [polypeptide binding]; other site 743720008689 L13 binding site [polypeptide binding]; other site 743720008690 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 743720008691 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 743720008692 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 743720008693 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 743720008694 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 743720008695 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 743720008696 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 743720008697 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 743720008698 active site 743720008699 dimer interface [polypeptide binding]; other site 743720008700 motif 1; other site 743720008701 motif 2; other site 743720008702 motif 3; other site 743720008703 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 743720008704 anticodon binding site; other site 743720008705 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 743720008706 putative active site [active] 743720008707 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743720008708 binding surface 743720008709 Tetratricopeptide repeat; Region: TPR_16; pfam13432 743720008710 TPR motif; other site 743720008711 Tetratricopeptide repeat; Region: TPR_16; pfam13432 743720008712 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720008713 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720008714 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 743720008715 putative effector binding pocket; other site 743720008716 dimerization interface [polypeptide binding]; other site 743720008717 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 743720008718 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 743720008719 active site 743720008720 catalytic tetrad [active] 743720008721 hypothetical protein; Provisional; Region: PRK09256 743720008722 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 743720008723 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 743720008724 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 743720008725 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720008726 dimerization interface [polypeptide binding]; other site 743720008727 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720008728 dimer interface [polypeptide binding]; other site 743720008729 putative CheW interface [polypeptide binding]; other site 743720008730 aromatic amino acid transporter; Provisional; Region: PRK10238 743720008731 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 743720008732 maleylacetoacetate isomerase; Region: maiA; TIGR01262 743720008733 C-terminal domain interface [polypeptide binding]; other site 743720008734 GSH binding site (G-site) [chemical binding]; other site 743720008735 putative dimer interface [polypeptide binding]; other site 743720008736 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 743720008737 dimer interface [polypeptide binding]; other site 743720008738 N-terminal domain interface [polypeptide binding]; other site 743720008739 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 743720008740 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 743720008741 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 743720008742 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 743720008743 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 743720008744 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 743720008745 dimer interface [polypeptide binding]; other site 743720008746 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 743720008747 active site 743720008748 Fe binding site [ion binding]; other site 743720008749 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 743720008750 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743720008751 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 743720008752 Walker A/P-loop; other site 743720008753 ATP binding site [chemical binding]; other site 743720008754 Q-loop/lid; other site 743720008755 ABC transporter signature motif; other site 743720008756 Walker B; other site 743720008757 D-loop; other site 743720008758 H-loop/switch region; other site 743720008759 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 743720008760 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 743720008761 catalytic residues [active] 743720008762 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 743720008763 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 743720008764 active site residue [active] 743720008765 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 743720008766 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 743720008767 putative NAD(P) binding site [chemical binding]; other site 743720008768 BolA-like protein; Region: BolA; pfam01722 743720008769 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 743720008770 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 743720008771 fumarate hydratase; Provisional; Region: PRK12425 743720008772 Class II fumarases; Region: Fumarase_classII; cd01362 743720008773 active site 743720008774 tetramer interface [polypeptide binding]; other site 743720008775 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 743720008776 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 743720008777 Predicted permeases [General function prediction only]; Region: COG0679 743720008778 Predicted ATPase [General function prediction only]; Region: COG1485 743720008779 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 743720008780 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 743720008781 heterodimer interface [polypeptide binding]; other site 743720008782 active site 743720008783 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 743720008784 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 743720008785 active site 743720008786 glutathionine S-transferase; Provisional; Region: PRK10542 743720008787 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 743720008788 C-terminal domain interface [polypeptide binding]; other site 743720008789 GSH binding site (G-site) [chemical binding]; other site 743720008790 dimer interface [polypeptide binding]; other site 743720008791 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 743720008792 dimer interface [polypeptide binding]; other site 743720008793 N-terminal domain interface [polypeptide binding]; other site 743720008794 substrate binding pocket (H-site) [chemical binding]; other site 743720008795 Predicted transcriptional regulators [Transcription]; Region: COG1733 743720008796 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 743720008797 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 743720008798 Sel1-like repeats; Region: SEL1; smart00671 743720008799 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720008800 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 743720008801 NAD(P) binding site [chemical binding]; other site 743720008802 active site 743720008803 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 743720008804 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 743720008805 catalytic site [active] 743720008806 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 743720008807 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720008808 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720008809 dimerization interface [polypeptide binding]; other site 743720008810 glycogen synthase; Provisional; Region: glgA; PRK00654 743720008811 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 743720008812 ADP-binding pocket [chemical binding]; other site 743720008813 homodimer interface [polypeptide binding]; other site 743720008814 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 743720008815 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 743720008816 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 743720008817 catalytic site [active] 743720008818 active site 743720008819 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 743720008820 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 743720008821 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 743720008822 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 743720008823 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 743720008824 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 743720008825 active site 743720008826 catalytic site [active] 743720008827 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 743720008828 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 743720008829 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 743720008830 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 743720008831 active site 743720008832 catalytic site [active] 743720008833 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 743720008834 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 743720008835 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 743720008836 Methyltransferase domain; Region: Methyltransf_23; pfam13489 743720008837 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720008838 S-adenosylmethionine binding site [chemical binding]; other site 743720008839 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 743720008840 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 743720008841 active site 743720008842 FOG: CBS domain [General function prediction only]; Region: COG0517 743720008843 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 743720008844 Protein of unknown function DUF72; Region: DUF72; pfam01904 743720008845 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 743720008846 putative catalytic site [active] 743720008847 putative metal binding site [ion binding]; other site 743720008848 putative phosphate binding site [ion binding]; other site 743720008849 cardiolipin synthase 2; Provisional; Region: PRK11263 743720008850 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 743720008851 putative active site [active] 743720008852 catalytic site [active] 743720008853 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 743720008854 putative active site [active] 743720008855 catalytic site [active] 743720008856 Predicted integral membrane protein [Function unknown]; Region: COG0392 743720008857 Protein of unknown function (DUF3079); Region: DUF3079; pfam11278 743720008858 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 743720008859 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720008860 DNA-binding site [nucleotide binding]; DNA binding site 743720008861 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743720008862 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720008863 homodimer interface [polypeptide binding]; other site 743720008864 catalytic residue [active] 743720008865 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 743720008866 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 743720008867 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720008868 Coenzyme A binding pocket [chemical binding]; other site 743720008869 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 743720008870 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 743720008871 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 743720008872 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 743720008873 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 743720008874 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 743720008875 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720008876 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720008877 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 743720008878 glycogen branching enzyme; Provisional; Region: PRK05402 743720008879 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 743720008880 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 743720008881 active site 743720008882 catalytic site [active] 743720008883 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 743720008884 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 743720008885 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 743720008886 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 743720008887 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 743720008888 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 743720008889 active site 743720008890 homodimer interface [polypeptide binding]; other site 743720008891 catalytic site [active] 743720008892 acceptor binding site [chemical binding]; other site 743720008893 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 743720008894 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 743720008895 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 743720008896 active site 743720008897 DNA binding site [nucleotide binding] 743720008898 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 743720008899 DNA binding site [nucleotide binding] 743720008900 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 743720008901 nucleotide binding site [chemical binding]; other site 743720008902 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 743720008903 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 743720008904 putative DNA binding site [nucleotide binding]; other site 743720008905 putative homodimer interface [polypeptide binding]; other site 743720008906 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 743720008907 MgtC family; Region: MgtC; pfam02308 743720008908 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720008909 NAD(P) binding site [chemical binding]; other site 743720008910 NADH(P)-binding; Region: NAD_binding_10; pfam13460 743720008911 active site 743720008912 hydroperoxidase II; Provisional; Region: katE; PRK11249 743720008913 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 743720008914 tetramer interface [polypeptide binding]; other site 743720008915 heme binding pocket [chemical binding]; other site 743720008916 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 743720008917 domain interactions; other site 743720008918 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 743720008919 homodimer interface [polypeptide binding]; other site 743720008920 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 743720008921 active site pocket [active] 743720008922 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 743720008923 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 743720008924 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 743720008925 MarR family; Region: MarR; pfam01047 743720008926 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 743720008927 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 743720008928 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 743720008929 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720008930 NAD(P) binding site [chemical binding]; other site 743720008931 active site 743720008932 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 743720008933 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 743720008934 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720008935 Secretin and TonB N terminus short domain; Region: STN; smart00965 743720008936 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 743720008937 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743720008938 N-terminal plug; other site 743720008939 ligand-binding site [chemical binding]; other site 743720008940 fec operon regulator FecR; Reviewed; Region: PRK09774 743720008941 FecR protein; Region: FecR; pfam04773 743720008942 RNA polymerase sigma factor; Provisional; Region: PRK12528 743720008943 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743720008944 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 743720008945 DNA binding residues [nucleotide binding] 743720008946 recombination protein RecR; Reviewed; Region: recR; PRK00076 743720008947 RecR protein; Region: RecR; pfam02132 743720008948 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 743720008949 putative active site [active] 743720008950 putative metal-binding site [ion binding]; other site 743720008951 tetramer interface [polypeptide binding]; other site 743720008952 hypothetical protein; Validated; Region: PRK00153 743720008953 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 743720008954 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720008955 Walker A motif; other site 743720008956 ATP binding site [chemical binding]; other site 743720008957 Walker B motif; other site 743720008958 arginine finger; other site 743720008959 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 743720008960 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 743720008961 Domain of unknown function (DUF1287); Region: DUF1287; pfam06940 743720008962 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 743720008963 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 743720008964 ligand binding site [chemical binding]; other site 743720008965 NAD binding site [chemical binding]; other site 743720008966 catalytic site [active] 743720008967 homodimer interface [polypeptide binding]; other site 743720008968 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 743720008969 multidrug efflux protein; Reviewed; Region: PRK01766 743720008970 cation binding site [ion binding]; other site 743720008971 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 743720008972 CPxP motif; other site 743720008973 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 743720008974 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 743720008975 aconitate hydratase; Validated; Region: PRK09277 743720008976 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 743720008977 substrate binding site [chemical binding]; other site 743720008978 ligand binding site [chemical binding]; other site 743720008979 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 743720008980 substrate binding site [chemical binding]; other site 743720008981 PAS domain; Region: PAS_9; pfam13426 743720008982 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720008983 putative active site [active] 743720008984 heme pocket [chemical binding]; other site 743720008985 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720008986 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720008987 dimer interface [polypeptide binding]; other site 743720008988 putative CheW interface [polypeptide binding]; other site 743720008989 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 743720008990 DinB family; Region: DinB; cl17821 743720008991 DinB superfamily; Region: DinB_2; pfam12867 743720008992 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720008993 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 743720008994 Coenzyme A binding pocket [chemical binding]; other site 743720008995 Protein of unknown function (DUF2986); Region: DUF2986; pfam11661 743720008996 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 743720008997 putative substrate binding pocket [chemical binding]; other site 743720008998 trimer interface [polypeptide binding]; other site 743720008999 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 743720009000 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 743720009001 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 743720009002 Low-spin heme binding site [chemical binding]; other site 743720009003 Putative water exit pathway; other site 743720009004 Binuclear center (active site) [active] 743720009005 Putative proton exit pathway; other site 743720009006 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 743720009007 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 743720009008 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 743720009009 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 743720009010 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 743720009011 Cytochrome c; Region: Cytochrom_C; pfam00034 743720009012 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 743720009013 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 743720009014 Low-spin heme binding site [chemical binding]; other site 743720009015 Putative water exit pathway; other site 743720009016 Binuclear center (active site) [active] 743720009017 Putative proton exit pathway; other site 743720009018 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 743720009019 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 743720009020 Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545 743720009021 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 743720009022 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 743720009023 Cytochrome c; Region: Cytochrom_C; pfam00034 743720009024 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 743720009025 4Fe-4S binding domain; Region: Fer4_5; pfam12801 743720009026 4Fe-4S binding domain; Region: Fer4_3; pfam12798 743720009027 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 743720009028 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198 743720009029 FixH; Region: FixH; pfam05751 743720009030 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 743720009031 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 743720009032 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 743720009033 metal-binding site [ion binding] 743720009034 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 743720009035 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743720009036 motif II; other site 743720009037 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 743720009038 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 743720009039 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 743720009040 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743720009041 FeS/SAM binding site; other site 743720009042 HemN C-terminal domain; Region: HemN_C; pfam06969 743720009043 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 743720009044 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 743720009045 ligand binding site [chemical binding]; other site 743720009046 flexible hinge region; other site 743720009047 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 743720009048 putative switch regulator; other site 743720009049 non-specific DNA interactions [nucleotide binding]; other site 743720009050 DNA binding site [nucleotide binding] 743720009051 sequence specific DNA binding site [nucleotide binding]; other site 743720009052 putative cAMP binding site [chemical binding]; other site 743720009053 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 743720009054 active site 743720009055 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 743720009056 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 743720009057 tandem repeat interface [polypeptide binding]; other site 743720009058 oligomer interface [polypeptide binding]; other site 743720009059 active site residues [active] 743720009060 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 743720009061 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743720009062 motif II; other site 743720009063 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 743720009064 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 743720009065 RNA binding surface [nucleotide binding]; other site 743720009066 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 743720009067 active site 743720009068 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 743720009069 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 743720009070 homodimer interface [polypeptide binding]; other site 743720009071 oligonucleotide binding site [chemical binding]; other site 743720009072 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 743720009073 FAD binding domain; Region: FAD_binding_4; pfam01565 743720009074 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 743720009075 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 743720009076 Low molecular weight phosphatase family; Region: LMWPc; cd00115 743720009077 active site 743720009078 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 743720009079 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 743720009080 Ligand binding site; other site 743720009081 oligomer interface; other site 743720009082 Uncharacterized conserved protein [Function unknown]; Region: COG2835 743720009083 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 743720009084 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 743720009085 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 743720009086 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 743720009087 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 743720009088 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 743720009089 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 743720009090 Competence protein; Region: Competence; pfam03772 743720009091 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 743720009092 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 743720009093 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 743720009094 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 743720009095 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 743720009096 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 743720009097 Walker A/P-loop; other site 743720009098 ATP binding site [chemical binding]; other site 743720009099 Q-loop/lid; other site 743720009100 ABC transporter signature motif; other site 743720009101 Walker B; other site 743720009102 D-loop; other site 743720009103 H-loop/switch region; other site 743720009104 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 743720009105 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 743720009106 FtsX-like permease family; Region: FtsX; pfam02687 743720009107 PilZ domain; Region: PilZ; pfam07238 743720009108 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 743720009109 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 743720009110 active site 743720009111 catalytic site [active] 743720009112 metal binding site [ion binding]; metal-binding site 743720009113 Predicted kinase [General function prediction only]; Region: COG0645 743720009114 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 743720009115 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743720009116 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 743720009117 Protein of unknown function (DUF539); Region: DUF539; cl01129 743720009118 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 743720009119 ApbE family; Region: ApbE; pfam02424 743720009120 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 743720009121 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 743720009122 catalytic loop [active] 743720009123 iron binding site [ion binding]; other site 743720009124 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 743720009125 FAD binding pocket [chemical binding]; other site 743720009126 FAD binding motif [chemical binding]; other site 743720009127 phosphate binding motif [ion binding]; other site 743720009128 beta-alpha-beta structure motif; other site 743720009129 NAD binding pocket [chemical binding]; other site 743720009130 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 743720009131 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 743720009132 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 743720009133 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 743720009134 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 743720009135 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 743720009136 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 743720009137 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 743720009138 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 743720009139 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 743720009140 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 743720009141 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 743720009142 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743720009143 ATP binding site [chemical binding]; other site 743720009144 putative Mg++ binding site [ion binding]; other site 743720009145 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743720009146 nucleotide binding region [chemical binding]; other site 743720009147 ATP-binding site [chemical binding]; other site 743720009148 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 743720009149 beta-hexosaminidase; Provisional; Region: PRK05337 743720009150 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 743720009151 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 743720009152 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 743720009153 LexA repressor; Validated; Region: PRK00215 743720009154 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 743720009155 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 743720009156 Catalytic site [active] 743720009157 Cell division inhibitor SulA; Region: SulA; cl01880 743720009158 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 743720009159 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 743720009160 active site 743720009161 interdomain interaction site; other site 743720009162 putative metal-binding site [ion binding]; other site 743720009163 nucleotide binding site [chemical binding]; other site 743720009164 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 743720009165 domain I; other site 743720009166 DNA binding groove [nucleotide binding] 743720009167 phosphate binding site [ion binding]; other site 743720009168 domain II; other site 743720009169 domain III; other site 743720009170 nucleotide binding site [chemical binding]; other site 743720009171 catalytic site [active] 743720009172 domain IV; other site 743720009173 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 743720009174 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 743720009175 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 743720009176 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 743720009177 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 743720009178 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 743720009179 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 743720009180 dimer interface [polypeptide binding]; other site 743720009181 active site 743720009182 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 743720009183 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 743720009184 substrate binding site [chemical binding]; other site 743720009185 oxyanion hole (OAH) forming residues; other site 743720009186 trimer interface [polypeptide binding]; other site 743720009187 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 743720009188 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 743720009189 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 743720009190 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 743720009191 Ligand Binding Site [chemical binding]; other site 743720009192 ABC transporter ATPase component; Reviewed; Region: PRK11147 743720009193 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 743720009194 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 743720009195 ABC transporter; Region: ABC_tran_2; pfam12848 743720009196 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 743720009197 lytic murein transglycosylase; Provisional; Region: PRK11619 743720009198 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 743720009199 N-acetyl-D-glucosamine binding site [chemical binding]; other site 743720009200 catalytic residue [active] 743720009201 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 743720009202 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 743720009203 MOSC domain; Region: MOSC; pfam03473 743720009204 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 743720009205 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 743720009206 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720009207 active site 743720009208 phosphorylation site [posttranslational modification] 743720009209 intermolecular recognition site; other site 743720009210 dimerization interface [polypeptide binding]; other site 743720009211 lipid kinase; Reviewed; Region: PRK13054 743720009212 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 743720009213 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 743720009214 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 743720009215 dimer interface [polypeptide binding]; other site 743720009216 putative functional site; other site 743720009217 putative MPT binding site; other site 743720009218 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 743720009219 MPT binding site; other site 743720009220 trimer interface [polypeptide binding]; other site 743720009221 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 743720009222 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 743720009223 GTP binding site; other site 743720009224 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 743720009225 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 743720009226 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 743720009227 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 743720009228 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 743720009229 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720009230 dimer interface [polypeptide binding]; other site 743720009231 phosphorylation site [posttranslational modification] 743720009232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720009233 ATP binding site [chemical binding]; other site 743720009234 G-X-G motif; other site 743720009235 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 743720009236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720009237 active site 743720009238 phosphorylation site [posttranslational modification] 743720009239 intermolecular recognition site; other site 743720009240 dimerization interface [polypeptide binding]; other site 743720009241 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743720009242 DNA binding site [nucleotide binding] 743720009243 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 743720009244 Periplasmic nitrate reductase protein NapE; Region: NapE; pfam06796 743720009245 NapD protein; Region: NapD; pfam03927 743720009246 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 743720009247 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 743720009248 [4Fe-4S] binding site [ion binding]; other site 743720009249 molybdopterin cofactor binding site; other site 743720009250 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 743720009251 molybdopterin cofactor binding site; other site 743720009252 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892 743720009253 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 743720009254 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 743720009255 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 743720009256 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 743720009257 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 743720009258 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 743720009259 active site 743720009260 metal binding site [ion binding]; metal-binding site 743720009261 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 743720009262 dimer interface [polypeptide binding]; other site 743720009263 active site 743720009264 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 743720009265 Mechanosensitive ion channel; Region: MS_channel; pfam00924 743720009266 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 743720009267 Peptidase family M48; Region: Peptidase_M48; cl12018 743720009268 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 743720009269 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 743720009270 glucosylglycerol 3-phosphatase; Region: salt_tol_Pase; TIGR02399 743720009271 Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase); Region: Salt_tol_Pase; pfam09506 743720009272 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 743720009273 Protein of unknown function (DUF2167); Region: DUF2167; pfam09935 743720009274 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 743720009275 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720009276 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720009277 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 743720009278 putative effector binding pocket; other site 743720009279 dimerization interface [polypeptide binding]; other site 743720009280 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 743720009281 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 743720009282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 743720009283 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 743720009284 Uncharacterized conserved protein [Function unknown]; Region: COG3791 743720009285 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 743720009286 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 743720009287 active site 743720009288 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 743720009289 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 743720009290 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 743720009291 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 743720009292 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 743720009293 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720009294 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720009295 dimerization interface [polypeptide binding]; other site 743720009296 LysE type translocator; Region: LysE; cl00565 743720009297 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 743720009298 Beta-lactamase; Region: Beta-lactamase; pfam00144 743720009299 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 743720009300 hypothetical protein; Provisional; Region: PRK12378 743720009301 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 743720009302 nudix motif; other site 743720009303 Protein of unknown function (DUF2025); Region: DUF2025; pfam09634 743720009304 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720009305 Coenzyme A binding pocket [chemical binding]; other site 743720009306 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743720009307 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720009308 metal binding site [ion binding]; metal-binding site 743720009309 active site 743720009310 I-site; other site 743720009311 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 743720009312 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 743720009313 Na binding site [ion binding]; other site 743720009314 Predicted membrane protein [Function unknown]; Region: COG3162 743720009315 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 743720009316 amidase; Validated; Region: PRK06565 743720009317 Amidase; Region: Amidase; cl11426 743720009318 AzlC protein; Region: AzlC; cl00570 743720009319 Secretin and TonB N terminus short domain; Region: STN; smart00965 743720009320 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 743720009321 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743720009322 N-terminal plug; other site 743720009323 ligand-binding site [chemical binding]; other site 743720009324 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 743720009325 FecR protein; Region: FecR; pfam04773 743720009326 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743720009327 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 743720009328 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743720009329 DNA binding residues [nucleotide binding] 743720009330 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 743720009331 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 743720009332 putative C-terminal domain interface [polypeptide binding]; other site 743720009333 putative GSH binding site (G-site) [chemical binding]; other site 743720009334 putative dimer interface [polypeptide binding]; other site 743720009335 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 743720009336 putative N-terminal domain interface [polypeptide binding]; other site 743720009337 putative dimer interface [polypeptide binding]; other site 743720009338 putative substrate binding pocket (H-site) [chemical binding]; other site 743720009339 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 743720009340 S1 domain; Region: S1_2; pfam13509 743720009341 S1 domain; Region: S1_2; pfam13509 743720009342 Sulfatase; Region: Sulfatase; pfam00884 743720009343 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 743720009344 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 743720009345 active site 743720009346 catalytic residues [active] 743720009347 helicase 45; Provisional; Region: PTZ00424 743720009348 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 743720009349 ATP binding site [chemical binding]; other site 743720009350 Mg++ binding site [ion binding]; other site 743720009351 motif III; other site 743720009352 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743720009353 nucleotide binding region [chemical binding]; other site 743720009354 ATP-binding site [chemical binding]; other site 743720009355 Predicted permeases [General function prediction only]; Region: RarD; COG2962 743720009356 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720009357 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720009358 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720009359 dimerization interface [polypeptide binding]; other site 743720009360 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 743720009361 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 743720009362 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 743720009363 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 743720009364 substrate binding site [chemical binding]; other site 743720009365 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 743720009366 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 743720009367 Walker A/P-loop; other site 743720009368 ATP binding site [chemical binding]; other site 743720009369 Q-loop/lid; other site 743720009370 ABC transporter signature motif; other site 743720009371 Walker B; other site 743720009372 D-loop; other site 743720009373 H-loop/switch region; other site 743720009374 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 743720009375 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 743720009376 Protein of unknown function, DUF482; Region: DUF482; pfam04339 743720009377 Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746 743720009378 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 743720009379 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 743720009380 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 743720009381 dimer interface [polypeptide binding]; other site 743720009382 active site 743720009383 CoA binding pocket [chemical binding]; other site 743720009384 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 743720009385 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720009386 NAD(P) binding site [chemical binding]; other site 743720009387 active site 743720009388 Predicted transcriptional regulators [Transcription]; Region: COG1733 743720009389 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 743720009390 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 743720009391 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 743720009392 NAD(P) binding site [chemical binding]; other site 743720009393 carboxy-terminal protease; Provisional; Region: PRK11186 743720009394 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 743720009395 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 743720009396 protein binding site [polypeptide binding]; other site 743720009397 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 743720009398 Catalytic dyad [active] 743720009399 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 743720009400 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743720009401 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 743720009402 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743720009403 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720009404 metal binding site [ion binding]; metal-binding site 743720009405 active site 743720009406 I-site; other site 743720009407 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK07192 743720009408 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 743720009409 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07191 743720009410 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 743720009411 Rod binding protein; Region: Rod-binding; cl01626 743720009412 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 743720009413 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 743720009414 N-acetyl-D-glucosamine binding site [chemical binding]; other site 743720009415 catalytic residue [active] 743720009416 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 743720009417 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 743720009418 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12407 743720009419 Flagellar L-ring protein; Region: FlgH; pfam02107 743720009420 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 743720009421 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 743720009422 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 743720009423 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 743720009424 flagellar hook protein FlgE; Validated; Region: flgE; PRK06803 743720009425 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 743720009426 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 743720009427 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 743720009428 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK09619 743720009429 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 743720009430 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 743720009431 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK06802 743720009432 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 743720009433 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 743720009434 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK12685 743720009435 SAF-like; Region: SAF_2; pfam13144 743720009436 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 743720009437 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 743720009438 flagellin; Provisional; Region: PRK12802 743720009439 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 743720009440 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 743720009441 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 743720009442 DNA binding site [nucleotide binding] 743720009443 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 743720009444 hypothetical protein; Validated; Region: PRK06778 743720009445 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 743720009446 ligand binding site [chemical binding]; other site 743720009447 flagellar motor protein MotA; Provisional; Region: PRK12482 743720009448 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 743720009449 flagellar biosynthesis sigma factor; Provisional; Region: PRK12427 743720009450 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743720009451 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743720009452 DNA binding residues [nucleotide binding] 743720009453 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 743720009454 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 743720009455 Flagellar protein FliS; Region: FliS; cl00654 743720009456 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 743720009457 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 743720009458 FlgN protein; Region: FlgN; pfam05130 743720009459 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 743720009460 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 743720009461 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 743720009462 Walker A motif; other site 743720009463 ATP binding site [chemical binding]; other site 743720009464 Walker B motif; other site 743720009465 flagellar assembly protein H; Provisional; Region: fliH; PRK13386 743720009466 Flagellar assembly protein FliH; Region: FliH; pfam02108 743720009467 flagellar motor switch protein G; Reviewed; Region: fliG; PRK07194 743720009468 FliG C-terminal domain; Region: FliG_C; pfam01706 743720009469 flagellar MS-ring protein; Reviewed; Region: fliF; PRK07193 743720009470 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 743720009471 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 743720009472 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 743720009473 acetoacetate metabolism regulatory protein AtoC; Provisional; Region: PRK11361 743720009474 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720009475 Walker A motif; other site 743720009476 ATP binding site [chemical binding]; other site 743720009477 Walker B motif; other site 743720009478 arginine finger; other site 743720009479 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 743720009480 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 743720009481 flagellar motor switch protein FliN; Region: fliN; TIGR02480 743720009482 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 743720009483 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 743720009484 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 743720009485 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 743720009486 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 743720009487 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 743720009488 FHIPEP family; Region: FHIPEP; pfam00771 743720009489 PilZ domain; Region: PilZ; pfam07238 743720009490 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 743720009491 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 743720009492 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 743720009493 non-specific DNA binding site [nucleotide binding]; other site 743720009494 salt bridge; other site 743720009495 sequence-specific DNA binding site [nucleotide binding]; other site 743720009496 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 743720009497 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 743720009498 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 743720009499 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 743720009500 HlyD family secretion protein; Region: HlyD_3; pfam13437 743720009501 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 743720009502 Protein export membrane protein; Region: SecD_SecF; cl14618 743720009503 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 743720009504 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 743720009505 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720009506 dimerization interface [polypeptide binding]; other site 743720009507 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720009508 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720009509 dimer interface [polypeptide binding]; other site 743720009510 putative CheW interface [polypeptide binding]; other site 743720009511 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743720009512 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 743720009513 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 743720009514 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720009515 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 743720009516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720009517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720009518 oxidoreductase; Validated; Region: PRK05717 743720009519 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720009520 NAD(P) binding site [chemical binding]; other site 743720009521 active site 743720009522 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 743720009523 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 743720009524 homodimer interface [polypeptide binding]; other site 743720009525 substrate-cofactor binding pocket; other site 743720009526 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720009527 catalytic residue [active] 743720009528 amidophosphoribosyltransferase; Provisional; Region: PRK09246 743720009529 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 743720009530 active site 743720009531 tetramer interface [polypeptide binding]; other site 743720009532 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 743720009533 active site 743720009534 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 743720009535 Colicin V production protein; Region: Colicin_V; cl00567 743720009536 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 743720009537 Sporulation related domain; Region: SPOR; pfam05036 743720009538 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 743720009539 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 743720009540 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 743720009541 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 743720009542 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 743720009543 active site 743720009544 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 743720009545 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 743720009546 dimerization interface 3.5A [polypeptide binding]; other site 743720009547 active site 743720009548 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 743720009549 FimV N-terminal domain; Region: FimV_core; TIGR03505 743720009550 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 743720009551 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK05671 743720009552 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 743720009553 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 743720009554 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 743720009555 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 743720009556 tartrate dehydrogenase; Region: TTC; TIGR02089 743720009557 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 743720009558 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 743720009559 substrate binding site [chemical binding]; other site 743720009560 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 743720009561 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 743720009562 substrate binding site [chemical binding]; other site 743720009563 ligand binding site [chemical binding]; other site 743720009564 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720009565 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720009566 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 743720009567 dimerization interface [polypeptide binding]; other site 743720009568 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720009569 PAS fold; Region: PAS_3; pfam08447 743720009570 putative active site [active] 743720009571 heme pocket [chemical binding]; other site 743720009572 PAS fold; Region: PAS_3; pfam08447 743720009573 PAS domain S-box; Region: sensory_box; TIGR00229 743720009574 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720009575 putative active site [active] 743720009576 heme pocket [chemical binding]; other site 743720009577 PAS domain S-box; Region: sensory_box; TIGR00229 743720009578 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720009579 putative active site [active] 743720009580 heme pocket [chemical binding]; other site 743720009581 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743720009582 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720009583 metal binding site [ion binding]; metal-binding site 743720009584 active site 743720009585 I-site; other site 743720009586 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743720009587 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 743720009588 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 743720009589 putative dimer interface [polypeptide binding]; other site 743720009590 short chain dehydrogenase; Provisional; Region: PRK06123 743720009591 classical (c) SDRs; Region: SDR_c; cd05233 743720009592 NAD(P) binding site [chemical binding]; other site 743720009593 active site 743720009594 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 743720009595 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 743720009596 FMN binding site [chemical binding]; other site 743720009597 active site 743720009598 catalytic residues [active] 743720009599 substrate binding site [chemical binding]; other site 743720009600 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 743720009601 active site 743720009602 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 743720009603 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 743720009604 active site 743720009605 HIGH motif; other site 743720009606 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 743720009607 active site 743720009608 KMSKS motif; other site 743720009609 Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613 743720009610 excinuclease ABC subunit B; Provisional; Region: PRK05298 743720009611 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743720009612 ATP binding site [chemical binding]; other site 743720009613 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743720009614 nucleotide binding region [chemical binding]; other site 743720009615 ATP-binding site [chemical binding]; other site 743720009616 Ultra-violet resistance protein B; Region: UvrB; pfam12344 743720009617 UvrB/uvrC motif; Region: UVR; pfam02151 743720009618 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 743720009619 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743720009620 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720009621 homodimer interface [polypeptide binding]; other site 743720009622 catalytic residue [active] 743720009623 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 743720009624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720009625 active site 743720009626 phosphorylation site [posttranslational modification] 743720009627 intermolecular recognition site; other site 743720009628 dimerization interface [polypeptide binding]; other site 743720009629 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720009630 Walker A motif; other site 743720009631 ATP binding site [chemical binding]; other site 743720009632 Walker B motif; other site 743720009633 arginine finger; other site 743720009634 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 743720009635 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720009636 dimer interface [polypeptide binding]; other site 743720009637 phosphorylation site [posttranslational modification] 743720009638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720009639 ATP binding site [chemical binding]; other site 743720009640 Mg2+ binding site [ion binding]; other site 743720009641 G-X-G motif; other site 743720009642 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 743720009643 Flagellar regulatory protein FleQ; Region: FleQ; pfam06490 743720009644 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720009645 Walker A motif; other site 743720009646 ATP binding site [chemical binding]; other site 743720009647 Walker B motif; other site 743720009648 arginine finger; other site 743720009649 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 743720009650 flagellar protein FliS; Validated; Region: fliS; PRK05685 743720009651 Flagellar protein FliS; Region: FliS; cl00654 743720009652 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 743720009653 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 743720009654 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 743720009655 FlaG protein; Region: FlaG; pfam03646 743720009656 flagellin; Reviewed; Region: PRK08869 743720009657 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 743720009658 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 743720009659 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 743720009660 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 743720009661 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK05683 743720009662 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 743720009663 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 743720009664 flagellar rod assembly protein/muramidase FlgJ; Provisional; Region: flgJ; PRK12712 743720009665 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 743720009666 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 743720009667 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 743720009668 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 743720009669 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 743720009670 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 743720009671 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 743720009672 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 743720009673 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 743720009674 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 743720009675 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 743720009676 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 743720009677 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 743720009678 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 743720009679 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 743720009680 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 743720009681 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 743720009682 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 743720009683 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 743720009684 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 743720009685 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 743720009686 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 743720009687 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 743720009688 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 743720009689 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 743720009690 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720009691 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 743720009692 Response regulator receiver domain; Region: Response_reg; pfam00072 743720009693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720009694 active site 743720009695 phosphorylation site [posttranslational modification] 743720009696 intermolecular recognition site; other site 743720009697 dimerization interface [polypeptide binding]; other site 743720009698 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 743720009699 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 743720009700 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 743720009701 FlgN protein; Region: FlgN; cl09176 743720009702 Flagellar regulator YcgR; Region: YcgR; pfam07317 743720009703 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 743720009704 PilZ domain; Region: PilZ; pfam07238 743720009705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720009706 putative MFS family transporter protein; Provisional; Region: PRK03633 743720009707 putative substrate translocation pore; other site 743720009708 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 743720009709 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 743720009710 dimer interface [polypeptide binding]; other site 743720009711 PYR/PP interface [polypeptide binding]; other site 743720009712 TPP binding site [chemical binding]; other site 743720009713 substrate binding site [chemical binding]; other site 743720009714 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 743720009715 TPP-binding site; other site 743720009716 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 743720009717 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 743720009718 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 743720009719 putative DNA binding site [nucleotide binding]; other site 743720009720 putative Zn2+ binding site [ion binding]; other site 743720009721 AsnC family; Region: AsnC_trans_reg; pfam01037 743720009722 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 743720009723 active site 743720009724 Arc-like DNA binding domain; Region: Arc; pfam03869 743720009725 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 743720009726 MgtE intracellular N domain; Region: MgtE_N; smart00924 743720009727 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 743720009728 Divalent cation transporter; Region: MgtE; cl00786 743720009729 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 743720009730 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 743720009731 carbon storage regulator; Provisional; Region: PRK01712 743720009732 aspartate kinase; Reviewed; Region: PRK06635 743720009733 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 743720009734 putative nucleotide binding site [chemical binding]; other site 743720009735 putative catalytic residues [active] 743720009736 putative Mg ion binding site [ion binding]; other site 743720009737 putative aspartate binding site [chemical binding]; other site 743720009738 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 743720009739 putative allosteric regulatory site; other site 743720009740 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 743720009741 putative allosteric regulatory residue; other site 743720009742 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 743720009743 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 743720009744 motif 1; other site 743720009745 active site 743720009746 motif 2; other site 743720009747 motif 3; other site 743720009748 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 743720009749 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 743720009750 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 743720009751 tetramer interface [polypeptide binding]; other site 743720009752 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720009753 catalytic residue [active] 743720009754 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 743720009755 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 743720009756 putative active site [active] 743720009757 Zn binding site [ion binding]; other site 743720009758 succinylarginine dihydrolase; Provisional; Region: PRK13281 743720009759 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 743720009760 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 743720009761 NAD(P) binding site [chemical binding]; other site 743720009762 catalytic residues [active] 743720009763 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 743720009764 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 743720009765 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 743720009766 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 743720009767 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 743720009768 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 743720009769 inhibitor-cofactor binding pocket; inhibition site 743720009770 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720009771 catalytic residue [active] 743720009772 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 743720009773 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 743720009774 FMN binding site [chemical binding]; other site 743720009775 substrate binding site [chemical binding]; other site 743720009776 putative catalytic residue [active] 743720009777 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 743720009778 EamA-like transporter family; Region: EamA; pfam00892 743720009779 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 743720009780 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 743720009781 glucose-1-dehydrogenase; Provisional; Region: PRK08936 743720009782 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 743720009783 NAD binding site [chemical binding]; other site 743720009784 homodimer interface [polypeptide binding]; other site 743720009785 active site 743720009786 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 743720009787 thiamine pyrophosphate protein; Provisional; Region: PRK08273 743720009788 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 743720009789 PYR/PP interface [polypeptide binding]; other site 743720009790 dimer interface [polypeptide binding]; other site 743720009791 tetramer interface [polypeptide binding]; other site 743720009792 TPP binding site [chemical binding]; other site 743720009793 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 743720009794 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 743720009795 TPP-binding site [chemical binding]; other site 743720009796 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 743720009797 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 743720009798 recombination associated protein; Reviewed; Region: rdgC; PRK00321 743720009799 bile acid transporter; Region: bass; TIGR00841 743720009800 Sodium Bile acid symporter family; Region: SBF; pfam01758 743720009801 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 743720009802 Major Facilitator Superfamily; Region: MFS_1; pfam07690 743720009803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720009804 putative substrate translocation pore; other site 743720009805 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 743720009806 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 743720009807 putative acyl-acceptor binding pocket; other site 743720009808 transcriptional regulator; Provisional; Region: PRK10632 743720009809 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720009810 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 743720009811 putative effector binding pocket; other site 743720009812 putative dimerization interface [polypeptide binding]; other site 743720009813 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 743720009814 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 743720009815 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 743720009816 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 743720009817 FAD binding pocket [chemical binding]; other site 743720009818 FAD binding motif [chemical binding]; other site 743720009819 phosphate binding motif [ion binding]; other site 743720009820 beta-alpha-beta structure motif; other site 743720009821 NAD binding pocket [chemical binding]; other site 743720009822 Heme binding pocket [chemical binding]; other site 743720009823 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 743720009824 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 743720009825 catalytic loop [active] 743720009826 iron binding site [ion binding]; other site 743720009827 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 743720009828 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 743720009829 putative C-terminal domain interface [polypeptide binding]; other site 743720009830 putative GSH binding site (G-site) [chemical binding]; other site 743720009831 putative dimer interface [polypeptide binding]; other site 743720009832 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 743720009833 putative N-terminal domain interface [polypeptide binding]; other site 743720009834 putative dimer interface [polypeptide binding]; other site 743720009835 putative substrate binding pocket (H-site) [chemical binding]; other site 743720009836 Predicted membrane protein [Function unknown]; Region: COG4392 743720009837 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 743720009838 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 743720009839 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 743720009840 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720009841 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 743720009842 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 743720009843 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 743720009844 Na binding site [ion binding]; other site 743720009845 PAS domain; Region: PAS; smart00091 743720009846 PAS fold; Region: PAS_7; pfam12860 743720009847 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743720009848 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720009849 dimer interface [polypeptide binding]; other site 743720009850 phosphorylation site [posttranslational modification] 743720009851 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720009852 ATP binding site [chemical binding]; other site 743720009853 Mg2+ binding site [ion binding]; other site 743720009854 G-X-G motif; other site 743720009855 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 743720009856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720009857 active site 743720009858 phosphorylation site [posttranslational modification] 743720009859 intermolecular recognition site; other site 743720009860 dimerization interface [polypeptide binding]; other site 743720009861 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 743720009862 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 743720009863 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 743720009864 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 743720009865 Interdomain contacts; other site 743720009866 Cytokine receptor motif; other site 743720009867 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 743720009868 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 743720009869 RmuC family; Region: RmuC; pfam02646 743720009870 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 743720009871 Dicarboxylate transport; Region: DctA-YdbH; pfam11739 743720009872 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 743720009873 Protein of unknown function (DUF1318); Region: DUF1318; pfam07027 743720009874 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 743720009875 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 743720009876 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720009877 DNA-binding site [nucleotide binding]; DNA binding site 743720009878 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743720009879 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720009880 homodimer interface [polypeptide binding]; other site 743720009881 catalytic residue [active] 743720009882 RNA polymerase sigma factor; Provisional; Region: PRK12528 743720009883 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743720009884 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743720009885 DNA binding residues [nucleotide binding] 743720009886 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 743720009887 FecR protein; Region: FecR; pfam04773 743720009888 Secretin and TonB N terminus short domain; Region: STN; smart00965 743720009889 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 743720009890 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743720009891 N-terminal plug; other site 743720009892 ligand-binding site [chemical binding]; other site 743720009893 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720009894 dimerization interface [polypeptide binding]; other site 743720009895 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720009896 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720009897 dimer interface [polypeptide binding]; other site 743720009898 putative CheW interface [polypeptide binding]; other site 743720009899 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 743720009900 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 743720009901 minor groove reading motif; other site 743720009902 helix-hairpin-helix signature motif; other site 743720009903 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 743720009904 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720009905 dimerization interface [polypeptide binding]; other site 743720009906 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720009907 dimer interface [polypeptide binding]; other site 743720009908 putative CheW interface [polypeptide binding]; other site 743720009909 putative S-transferase; Provisional; Region: PRK11752 743720009910 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 743720009911 C-terminal domain interface [polypeptide binding]; other site 743720009912 GSH binding site (G-site) [chemical binding]; other site 743720009913 dimer interface [polypeptide binding]; other site 743720009914 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 743720009915 dimer interface [polypeptide binding]; other site 743720009916 N-terminal domain interface [polypeptide binding]; other site 743720009917 active site 743720009918 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 743720009919 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 743720009920 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 743720009921 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 743720009922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 743720009923 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720009924 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720009925 LysR substrate binding domain; Region: LysR_substrate; pfam03466 743720009926 dimerization interface [polypeptide binding]; other site 743720009927 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 743720009928 homotrimer interaction site [polypeptide binding]; other site 743720009929 putative active site [active] 743720009930 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 743720009931 Isochorismatase family; Region: Isochorismatase; pfam00857 743720009932 catalytic triad [active] 743720009933 dimer interface [polypeptide binding]; other site 743720009934 conserved cis-peptide bond; other site 743720009935 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720009936 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 743720009937 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720009938 Uncharacterized conserved protein [Function unknown]; Region: COG3339 743720009939 Uncharacterized conserved protein [Function unknown]; Region: COG4544 743720009940 DNA Polymerase Y-family; Region: PolY_like; cd03468 743720009941 active site 743720009942 DNA binding site [nucleotide binding] 743720009943 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 743720009944 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 743720009945 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 743720009946 putative active site [active] 743720009947 putative PHP Thumb interface [polypeptide binding]; other site 743720009948 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 743720009949 generic binding surface I; other site 743720009950 generic binding surface II; other site 743720009951 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720009952 Coenzyme A binding pocket [chemical binding]; other site 743720009953 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 743720009954 apolar tunnel; other site 743720009955 heme binding site [chemical binding]; other site 743720009956 dimerization interface [polypeptide binding]; other site 743720009957 Protein of unknown function (DUF3034); Region: DUF3034; pfam11231 743720009958 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720009959 dimerization interface [polypeptide binding]; other site 743720009960 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743720009961 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720009962 metal binding site [ion binding]; metal-binding site 743720009963 active site 743720009964 I-site; other site 743720009965 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743720009966 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 743720009967 Cna protein B-type domain; Region: Cna_B; pfam05738 743720009968 Cupin domain; Region: Cupin_2; cl17218 743720009969 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720009970 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 743720009971 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720009972 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 743720009973 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720009974 Walker A motif; other site 743720009975 ATP binding site [chemical binding]; other site 743720009976 Walker B motif; other site 743720009977 arginine finger; other site 743720009978 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 743720009979 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720009980 putative substrate translocation pore; other site 743720009981 Major Facilitator Superfamily; Region: MFS_1; pfam07690 743720009982 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 743720009983 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 743720009984 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 743720009985 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 743720009986 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 743720009987 Ligand binding site; other site 743720009988 DXD motif; other site 743720009989 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 743720009990 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 743720009991 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 743720009992 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 743720009993 dimerization interface [polypeptide binding]; other site 743720009994 ligand binding site [chemical binding]; other site 743720009995 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 743720009996 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 743720009997 TM-ABC transporter signature motif; other site 743720009998 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 743720009999 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 743720010000 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 743720010001 TM-ABC transporter signature motif; other site 743720010002 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 743720010003 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 743720010004 Walker A/P-loop; other site 743720010005 ATP binding site [chemical binding]; other site 743720010006 Q-loop/lid; other site 743720010007 ABC transporter signature motif; other site 743720010008 Walker B; other site 743720010009 D-loop; other site 743720010010 H-loop/switch region; other site 743720010011 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 743720010012 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 743720010013 Walker A/P-loop; other site 743720010014 ATP binding site [chemical binding]; other site 743720010015 Q-loop/lid; other site 743720010016 ABC transporter signature motif; other site 743720010017 Walker B; other site 743720010018 D-loop; other site 743720010019 H-loop/switch region; other site 743720010020 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 743720010021 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 743720010022 RNA binding surface [nucleotide binding]; other site 743720010023 Pseudouridine synthase, a subgroup of the RsuA family; Region: PSSA_1; cd02555 743720010024 active site 743720010025 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 743720010026 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 743720010027 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 743720010028 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 743720010029 homodimer interaction site [polypeptide binding]; other site 743720010030 cofactor binding site; other site 743720010031 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 743720010032 putative GSH binding site [chemical binding]; other site 743720010033 catalytic residues [active] 743720010034 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 743720010035 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 743720010036 putative [Fe4-S4] binding site [ion binding]; other site 743720010037 putative molybdopterin cofactor binding site [chemical binding]; other site 743720010038 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 743720010039 putative molybdopterin cofactor binding site; other site 743720010040 ornithine carbamoyltransferase; Provisional; Region: PRK00779 743720010041 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 743720010042 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 743720010043 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 743720010044 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 743720010045 Walker A/P-loop; other site 743720010046 ATP binding site [chemical binding]; other site 743720010047 Q-loop/lid; other site 743720010048 ABC transporter signature motif; other site 743720010049 Walker B; other site 743720010050 D-loop; other site 743720010051 H-loop/switch region; other site 743720010052 TOBE domain; Region: TOBE_2; pfam08402 743720010053 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 743720010054 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720010055 substrate binding pocket [chemical binding]; other site 743720010056 membrane-bound complex binding site; other site 743720010057 hinge residues; other site 743720010058 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 743720010059 putative deacylase active site [active] 743720010060 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 743720010061 amphipathic channel; other site 743720010062 Asn-Pro-Ala signature motifs; other site 743720010063 glycerol kinase; Provisional; Region: glpK; PRK00047 743720010064 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 743720010065 N- and C-terminal domain interface [polypeptide binding]; other site 743720010066 active site 743720010067 MgATP binding site [chemical binding]; other site 743720010068 catalytic site [active] 743720010069 metal binding site [ion binding]; metal-binding site 743720010070 glycerol binding site [chemical binding]; other site 743720010071 homotetramer interface [polypeptide binding]; other site 743720010072 homodimer interface [polypeptide binding]; other site 743720010073 FBP binding site [chemical binding]; other site 743720010074 protein IIAGlc interface [polypeptide binding]; other site 743720010075 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 743720010076 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 743720010077 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 743720010078 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 743720010079 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 743720010080 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 743720010081 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 743720010082 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720010083 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 743720010084 putative dimerization interface [polypeptide binding]; other site 743720010085 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 743720010086 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720010087 S-adenosylmethionine binding site [chemical binding]; other site 743720010088 Methyltransferase domain; Region: Methyltransf_31; pfam13847 743720010089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720010090 S-adenosylmethionine binding site [chemical binding]; other site 743720010091 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 743720010092 active site 743720010093 hydrophilic channel; other site 743720010094 dimerization interface [polypeptide binding]; other site 743720010095 catalytic residues [active] 743720010096 active site lid [active] 743720010097 Recombination protein O N terminal; Region: RecO_N; pfam11967 743720010098 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 743720010099 Recombination protein O C terminal; Region: RecO_C; pfam02565 743720010100 GTPase Era; Reviewed; Region: era; PRK00089 743720010101 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 743720010102 G1 box; other site 743720010103 GTP/Mg2+ binding site [chemical binding]; other site 743720010104 Switch I region; other site 743720010105 G2 box; other site 743720010106 Switch II region; other site 743720010107 G3 box; other site 743720010108 G4 box; other site 743720010109 G5 box; other site 743720010110 KH domain; Region: KH_2; pfam07650 743720010111 ribonuclease III; Reviewed; Region: rnc; PRK00102 743720010112 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 743720010113 dimerization interface [polypeptide binding]; other site 743720010114 active site 743720010115 metal binding site [ion binding]; metal-binding site 743720010116 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 743720010117 dsRNA binding site [nucleotide binding]; other site 743720010118 signal peptidase I; Provisional; Region: PRK10861 743720010119 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 743720010120 Catalytic site [active] 743720010121 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 743720010122 GTP-binding protein LepA; Provisional; Region: PRK05433 743720010123 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 743720010124 G1 box; other site 743720010125 putative GEF interaction site [polypeptide binding]; other site 743720010126 GTP/Mg2+ binding site [chemical binding]; other site 743720010127 Switch I region; other site 743720010128 G2 box; other site 743720010129 G3 box; other site 743720010130 Switch II region; other site 743720010131 G4 box; other site 743720010132 G5 box; other site 743720010133 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 743720010134 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 743720010135 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 743720010136 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 743720010137 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 743720010138 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 743720010139 protein binding site [polypeptide binding]; other site 743720010140 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 743720010141 protein binding site [polypeptide binding]; other site 743720010142 anti-sigma E factor; Provisional; Region: rseB; PRK09455 743720010143 MucB/RseB family; Region: MucB_RseB; pfam03888 743720010144 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073 743720010145 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 743720010146 RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923 743720010147 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743720010148 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743720010149 DNA binding residues [nucleotide binding] 743720010150 L-aspartate oxidase; Provisional; Region: PRK09077 743720010151 L-aspartate oxidase; Provisional; Region: PRK06175 743720010152 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 743720010153 Uncharacterized conserved protein [Function unknown]; Region: COG2938 743720010154 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 743720010155 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 743720010156 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 743720010157 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 743720010158 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743720010159 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 743720010160 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720010161 dimer interface [polypeptide binding]; other site 743720010162 phosphorylation site [posttranslational modification] 743720010163 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720010164 ATP binding site [chemical binding]; other site 743720010165 Mg2+ binding site [ion binding]; other site 743720010166 G-X-G motif; other site 743720010167 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 743720010168 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720010169 active site 743720010170 phosphorylation site [posttranslational modification] 743720010171 intermolecular recognition site; other site 743720010172 dimerization interface [polypeptide binding]; other site 743720010173 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743720010174 DNA binding site [nucleotide binding] 743720010175 outer membrane porin, OprD family; Region: OprD; pfam03573 743720010176 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 743720010177 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 743720010178 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 743720010179 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 743720010180 Putative ammonia monooxygenase; Region: AmoA; pfam05145 743720010181 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 743720010182 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 743720010183 ligand binding site [chemical binding]; other site 743720010184 active site 743720010185 UGI interface [polypeptide binding]; other site 743720010186 catalytic site [active] 743720010187 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 743720010188 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 743720010189 enoyl-CoA hydratase; Provisional; Region: PRK09076 743720010190 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 743720010191 substrate binding site [chemical binding]; other site 743720010192 oxyanion hole (OAH) forming residues; other site 743720010193 trimer interface [polypeptide binding]; other site 743720010194 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 743720010195 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 743720010196 substrate binding site [chemical binding]; other site 743720010197 oxyanion hole (OAH) forming residues; other site 743720010198 trimer interface [polypeptide binding]; other site 743720010199 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 743720010200 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 743720010201 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 743720010202 HlyD family secretion protein; Region: HlyD_3; pfam13437 743720010203 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 743720010204 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 743720010205 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 743720010206 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 743720010207 Walker A/P-loop; other site 743720010208 ATP binding site [chemical binding]; other site 743720010209 Q-loop/lid; other site 743720010210 ABC transporter signature motif; other site 743720010211 Walker B; other site 743720010212 D-loop; other site 743720010213 H-loop/switch region; other site 743720010214 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 743720010215 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 743720010216 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 743720010217 PA14 domain; Region: PA14; cl08459 743720010218 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 743720010219 Calx-beta domain; Region: Calx-beta; cl02522 743720010220 Calx-beta domain; Region: Calx-beta; cl02522 743720010221 Calx-beta domain; Region: Calx-beta; cl02522 743720010222 Calx-beta domain; Region: Calx-beta; cl02522 743720010223 Calx-beta domain; Region: Calx-beta; cl02522 743720010224 Calx-beta domain; Region: Calx-beta; cl02522 743720010225 Calx-beta domain; Region: Calx-beta; cl02522 743720010226 Calx-beta domain; Region: Calx-beta; cl02522 743720010227 PA14 domain; Region: PA14; cl08459 743720010228 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 743720010229 metal ion-dependent adhesion site (MIDAS); other site 743720010230 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 743720010231 HAMP domain; Region: HAMP; pfam00672 743720010232 dimerization interface [polypeptide binding]; other site 743720010233 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743720010234 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720010235 metal binding site [ion binding]; metal-binding site 743720010236 active site 743720010237 I-site; other site 743720010238 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743720010239 Predicted transglutaminase-like cysteine proteinase [General function prediction only]; Region: COG3672 743720010240 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 743720010241 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 743720010242 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 743720010243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720010244 dimer interface [polypeptide binding]; other site 743720010245 conserved gate region; other site 743720010246 ABC-ATPase subunit interface; other site 743720010247 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 743720010248 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 743720010249 Walker A/P-loop; other site 743720010250 ATP binding site [chemical binding]; other site 743720010251 Q-loop/lid; other site 743720010252 ABC transporter signature motif; other site 743720010253 Walker B; other site 743720010254 D-loop; other site 743720010255 H-loop/switch region; other site 743720010256 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 743720010257 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 743720010258 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 743720010259 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 743720010260 urea carboxylase; Region: urea_carbox; TIGR02712 743720010261 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 743720010262 ATP-grasp domain; Region: ATP-grasp_4; cl17255 743720010263 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 743720010264 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 743720010265 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 743720010266 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 743720010267 carboxyltransferase (CT) interaction site; other site 743720010268 biotinylation site [posttranslational modification]; other site 743720010269 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743720010270 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720010271 metal binding site [ion binding]; metal-binding site 743720010272 active site 743720010273 I-site; other site 743720010274 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 743720010275 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 743720010276 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 743720010277 RNA binding surface [nucleotide binding]; other site 743720010278 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 743720010279 active site 743720010280 uracil binding [chemical binding]; other site 743720010281 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 743720010282 TIR domain; Region: TIR_2; pfam13676 743720010283 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 743720010284 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 743720010285 intersubunit interface [polypeptide binding]; other site 743720010286 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 743720010287 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 743720010288 ABC-ATPase subunit interface; other site 743720010289 dimer interface [polypeptide binding]; other site 743720010290 putative PBP binding regions; other site 743720010291 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 743720010292 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 743720010293 Walker A/P-loop; other site 743720010294 ATP binding site [chemical binding]; other site 743720010295 Q-loop/lid; other site 743720010296 ABC transporter signature motif; other site 743720010297 Walker B; other site 743720010298 D-loop; other site 743720010299 H-loop/switch region; other site 743720010300 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 743720010301 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743720010302 N-terminal plug; other site 743720010303 ligand-binding site [chemical binding]; other site 743720010304 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 743720010305 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 743720010306 potential catalytic triad [active] 743720010307 conserved cys residue [active] 743720010308 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 743720010309 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720010310 dimerization interface [polypeptide binding]; other site 743720010311 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720010312 dimer interface [polypeptide binding]; other site 743720010313 phosphorylation site [posttranslational modification] 743720010314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720010315 ATP binding site [chemical binding]; other site 743720010316 G-X-G motif; other site 743720010317 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 743720010318 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720010319 active site 743720010320 phosphorylation site [posttranslational modification] 743720010321 intermolecular recognition site; other site 743720010322 dimerization interface [polypeptide binding]; other site 743720010323 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743720010324 DNA binding site [nucleotide binding] 743720010325 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 743720010326 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743720010327 N-terminal plug; other site 743720010328 ligand-binding site [chemical binding]; other site 743720010329 GTP-binding protein Der; Reviewed; Region: PRK00093 743720010330 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 743720010331 G1 box; other site 743720010332 GTP/Mg2+ binding site [chemical binding]; other site 743720010333 Switch I region; other site 743720010334 G2 box; other site 743720010335 Switch II region; other site 743720010336 G3 box; other site 743720010337 G4 box; other site 743720010338 G5 box; other site 743720010339 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 743720010340 G1 box; other site 743720010341 GTP/Mg2+ binding site [chemical binding]; other site 743720010342 Switch I region; other site 743720010343 G2 box; other site 743720010344 G3 box; other site 743720010345 Switch II region; other site 743720010346 G4 box; other site 743720010347 G5 box; other site 743720010348 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 743720010349 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 743720010350 Trp docking motif [polypeptide binding]; other site 743720010351 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 743720010352 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 743720010353 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 743720010354 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 743720010355 dimer interface [polypeptide binding]; other site 743720010356 motif 1; other site 743720010357 active site 743720010358 motif 2; other site 743720010359 motif 3; other site 743720010360 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 743720010361 anticodon binding site; other site 743720010362 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 743720010363 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 743720010364 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 743720010365 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 743720010366 non-specific DNA binding site [nucleotide binding]; other site 743720010367 salt bridge; other site 743720010368 sequence-specific DNA binding site [nucleotide binding]; other site 743720010369 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 743720010370 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 743720010371 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743720010372 binding surface 743720010373 TPR motif; other site 743720010374 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743720010375 binding surface 743720010376 TPR motif; other site 743720010377 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 743720010378 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743720010379 FeS/SAM binding site; other site 743720010380 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 743720010381 active site 743720010382 multimer interface [polypeptide binding]; other site 743720010383 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 743720010384 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 743720010385 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 743720010386 catalytic loop [active] 743720010387 iron binding site [ion binding]; other site 743720010388 chaperone protein HscA; Provisional; Region: hscA; PRK05183 743720010389 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 743720010390 nucleotide binding site [chemical binding]; other site 743720010391 putative NEF/HSP70 interaction site [polypeptide binding]; other site 743720010392 SBD interface [polypeptide binding]; other site 743720010393 co-chaperone HscB; Provisional; Region: hscB; PRK00294 743720010394 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 743720010395 HSP70 interaction site [polypeptide binding]; other site 743720010396 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 743720010397 iron-sulfur cluster assembly protein IscA; Region: IscA; TIGR02011 743720010398 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 743720010399 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 743720010400 trimerization site [polypeptide binding]; other site 743720010401 active site 743720010402 cysteine desulfurase; Provisional; Region: PRK14012 743720010403 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 743720010404 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 743720010405 catalytic residue [active] 743720010406 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 743720010407 Rrf2 family protein; Region: rrf2_super; TIGR00738 743720010408 serine O-acetyltransferase; Region: cysE; TIGR01172 743720010409 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 743720010410 trimer interface [polypeptide binding]; other site 743720010411 active site 743720010412 substrate binding site [chemical binding]; other site 743720010413 CoA binding site [chemical binding]; other site 743720010414 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 743720010415 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 743720010416 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 743720010417 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 743720010418 active site 743720010419 dimerization interface [polypeptide binding]; other site 743720010420 hypothetical protein; Provisional; Region: PRK11280 743720010421 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 743720010422 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 743720010423 Protein export membrane protein; Region: SecD_SecF; pfam02355 743720010424 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 743720010425 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 743720010426 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 743720010427 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 743720010428 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 743720010429 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 743720010430 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 743720010431 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 743720010432 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 743720010433 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 743720010434 DNA-binding site [nucleotide binding]; DNA binding site 743720010435 RNA-binding motif; other site 743720010436 RDD family; Region: RDD; pfam06271 743720010437 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 743720010438 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 743720010439 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 743720010440 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 743720010441 multifunctional aminopeptidase A; Provisional; Region: PRK00913 743720010442 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 743720010443 interface (dimer of trimers) [polypeptide binding]; other site 743720010444 Substrate-binding/catalytic site; other site 743720010445 Zn-binding sites [ion binding]; other site 743720010446 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 743720010447 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 743720010448 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 743720010449 HIGH motif; other site 743720010450 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 743720010451 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 743720010452 active site 743720010453 KMSKS motif; other site 743720010454 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 743720010455 tRNA binding surface [nucleotide binding]; other site 743720010456 anticodon binding site; other site 743720010457 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 743720010458 Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; cl11547 743720010459 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 743720010460 transmembrane helices; other site 743720010461 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 743720010462 TrkA-C domain; Region: TrkA_C; pfam02080 743720010463 TrkA-C domain; Region: TrkA_C; pfam02080 743720010464 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 743720010465 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 743720010466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720010467 S-adenosylmethionine binding site [chemical binding]; other site 743720010468 Protein of unknown function (DUF998); Region: DUF998; pfam06197 743720010469 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 743720010470 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 743720010471 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 743720010472 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 743720010473 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 743720010474 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 743720010475 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 743720010476 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 743720010477 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 743720010478 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 743720010479 Domain of unknown function (DUF4040); Region: DUF4040; pfam13244 743720010480 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 743720010481 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 743720010482 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 743720010483 fructuronate transporter; Provisional; Region: PRK10034; cl15264 743720010484 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 743720010485 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 743720010486 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 743720010487 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 743720010488 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 743720010489 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 743720010490 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 743720010491 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 743720010492 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 743720010493 ligand binding site [chemical binding]; other site 743720010494 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 743720010495 Beta-lactamase; Region: Beta-lactamase; pfam00144 743720010496 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 743720010497 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 743720010498 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 743720010499 Predicted integral membrane protein [Function unknown]; Region: COG5615 743720010500 Protein of unknown function (DUF1145); Region: DUF1145; cl11481 743720010501 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 743720010502 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 743720010503 ligand binding site [chemical binding]; other site 743720010504 hypothetical protein; Provisional; Region: PRK00183 743720010505 SEC-C motif; Region: SEC-C; pfam02810 743720010506 LEA14-like dessication related protein [Defense mechanisms]; Region: COG5608 743720010507 Water Stress and Hypersensitive response; Region: WHy; smart00769 743720010508 SEC-C motif; Region: SEC-C; pfam02810 743720010509 Protein of unknown function (DUF2489); Region: DUF2489; pfam10675 743720010510 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 743720010511 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 743720010512 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 743720010513 active site 743720010514 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 743720010515 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743720010516 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 743720010517 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 743720010518 [4Fe-4S] binding site [ion binding]; other site 743720010519 molybdopterin cofactor binding site; other site 743720010520 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 743720010521 molybdopterin cofactor binding site; other site 743720010522 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 743720010523 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 743720010524 active site 743720010525 SAM binding site [chemical binding]; other site 743720010526 homodimer interface [polypeptide binding]; other site 743720010527 Nitrate and nitrite sensing; Region: NIT; pfam08376 743720010528 ANTAR domain; Region: ANTAR; pfam03861 743720010529 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 743720010530 NMT1-like family; Region: NMT1_2; pfam13379 743720010531 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 743720010532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720010533 dimer interface [polypeptide binding]; other site 743720010534 conserved gate region; other site 743720010535 putative PBP binding loops; other site 743720010536 ABC-ATPase subunit interface; other site 743720010537 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 743720010538 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 743720010539 Walker A/P-loop; other site 743720010540 ATP binding site [chemical binding]; other site 743720010541 Q-loop/lid; other site 743720010542 ABC transporter signature motif; other site 743720010543 Walker B; other site 743720010544 D-loop; other site 743720010545 H-loop/switch region; other site 743720010546 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 743720010547 trimer interface [polypeptide binding]; other site 743720010548 active site 743720010549 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 743720010550 DNA-binding site [nucleotide binding]; DNA binding site 743720010551 RNA-binding motif; other site 743720010552 antiporter inner membrane protein; Provisional; Region: PRK11670 743720010553 Domain of unknown function DUF59; Region: DUF59; pfam01883 743720010554 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 743720010555 Walker A motif; other site 743720010556 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 743720010557 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 743720010558 ligand binding site [chemical binding]; other site 743720010559 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 743720010560 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 743720010561 active site 743720010562 HIGH motif; other site 743720010563 KMSKS motif; other site 743720010564 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 743720010565 tRNA binding surface [nucleotide binding]; other site 743720010566 anticodon binding site; other site 743720010567 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 743720010568 putative tRNA-binding site [nucleotide binding]; other site 743720010569 dimer interface [polypeptide binding]; other site 743720010570 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 743720010571 ferredoxin; Provisional; Region: PRK08764 743720010572 Putative Fe-S cluster; Region: FeS; pfam04060 743720010573 4Fe-4S binding domain; Region: Fer4; pfam00037 743720010574 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 743720010575 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 743720010576 minor groove reading motif; other site 743720010577 helix-hairpin-helix signature motif; other site 743720010578 substrate binding pocket [chemical binding]; other site 743720010579 active site 743720010580 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 743720010581 thioredoxin reductase; Provisional; Region: PRK10262 743720010582 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 743720010583 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743720010584 putative sulfate transport protein CysZ; Validated; Region: PRK04949 743720010585 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 743720010586 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 743720010587 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 743720010588 catalytic residues [active] 743720010589 dimer interface [polypeptide binding]; other site 743720010590 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 743720010591 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 743720010592 Protein of unknown function (DUF3565); Region: DUF3565; pfam12088 743720010593 propionate/acetate kinase; Provisional; Region: PRK12379 743720010594 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 743720010595 nucleotide binding site [chemical binding]; other site 743720010596 Butyrate kinase [Energy production and conversion]; Region: COG3426 743720010597 phosphate acetyltransferase; Reviewed; Region: PRK05632 743720010598 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 743720010599 DRTGG domain; Region: DRTGG; pfam07085 743720010600 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 743720010601 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 743720010602 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 743720010603 putative acyl-acceptor binding pocket; other site 743720010604 response regulator PleD; Reviewed; Region: pleD; PRK09581 743720010605 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720010606 active site 743720010607 phosphorylation site [posttranslational modification] 743720010608 intermolecular recognition site; other site 743720010609 dimerization interface [polypeptide binding]; other site 743720010610 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720010611 putative active site [active] 743720010612 heme pocket [chemical binding]; other site 743720010613 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720010614 metal binding site [ion binding]; metal-binding site 743720010615 active site 743720010616 I-site; other site 743720010617 putative outer membrane lipoprotein; Provisional; Region: PRK10510 743720010618 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 743720010619 ligand binding site [chemical binding]; other site 743720010620 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 743720010621 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 743720010622 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 743720010623 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 743720010624 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 743720010625 dimer interface [polypeptide binding]; other site 743720010626 acyl-activating enzyme (AAE) consensus motif; other site 743720010627 putative active site [active] 743720010628 AMP binding site [chemical binding]; other site 743720010629 putative CoA binding site [chemical binding]; other site 743720010630 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 743720010631 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 743720010632 dimer interface [polypeptide binding]; other site 743720010633 active site 743720010634 LysE type translocator; Region: LysE; cl00565 743720010635 glycerate dehydrogenase; Provisional; Region: PRK06487 743720010636 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 743720010637 putative ligand binding site [chemical binding]; other site 743720010638 putative NAD binding site [chemical binding]; other site 743720010639 catalytic site [active] 743720010640 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 743720010641 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 743720010642 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 743720010643 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720010644 S-adenosylmethionine binding site [chemical binding]; other site 743720010645 Predicted membrane protein [Function unknown]; Region: COG2119 743720010646 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 743720010647 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 743720010648 Peptidase family M48; Region: Peptidase_M48; pfam01435 743720010649 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 743720010650 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 743720010651 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 743720010652 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 743720010653 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 743720010654 putative acyl-acceptor binding pocket; other site 743720010655 hypothetical protein; Provisional; Region: PRK11627 743720010656 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 743720010657 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 743720010658 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 743720010659 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 743720010660 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743720010661 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 743720010662 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743720010663 DNA binding residues [nucleotide binding] 743720010664 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 743720010665 Peptidase family M23; Region: Peptidase_M23; pfam01551 743720010666 Domain of unknown function (DUF368); Region: DUF368; pfam04018 743720010667 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 743720010668 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720010669 S-adenosylmethionine binding site [chemical binding]; other site 743720010670 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 743720010671 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 743720010672 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 743720010673 Permutation of conserved domain; other site 743720010674 active site 743720010675 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 743720010676 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 743720010677 homotrimer interaction site [polypeptide binding]; other site 743720010678 zinc binding site [ion binding]; other site 743720010679 CDP-binding sites; other site 743720010680 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 743720010681 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 743720010682 dimerization interface [polypeptide binding]; other site 743720010683 DPS ferroxidase diiron center [ion binding]; other site 743720010684 ion pore; other site 743720010685 S-formylglutathione hydrolase; Region: PLN02442 743720010686 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 743720010687 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 743720010688 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 743720010689 substrate binding site [chemical binding]; other site 743720010690 catalytic Zn binding site [ion binding]; other site 743720010691 NAD binding site [chemical binding]; other site 743720010692 structural Zn binding site [ion binding]; other site 743720010693 dimer interface [polypeptide binding]; other site 743720010694 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720010695 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720010696 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720010697 dimerization interface [polypeptide binding]; other site 743720010698 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 743720010699 30S subunit binding site; other site 743720010700 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 743720010701 substrate binding site; other site 743720010702 dimer interface; other site 743720010703 Septum formation initiator; Region: DivIC; cl17659 743720010704 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 743720010705 enolase; Provisional; Region: eno; PRK00077 743720010706 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 743720010707 dimer interface [polypeptide binding]; other site 743720010708 metal binding site [ion binding]; metal-binding site 743720010709 substrate binding pocket [chemical binding]; other site 743720010710 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 743720010711 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 743720010712 CTP synthetase; Validated; Region: pyrG; PRK05380 743720010713 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 743720010714 Catalytic site [active] 743720010715 active site 743720010716 UTP binding site [chemical binding]; other site 743720010717 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 743720010718 active site 743720010719 putative oxyanion hole; other site 743720010720 catalytic triad [active] 743720010721 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 743720010722 Ligand Binding Site [chemical binding]; other site 743720010723 TilS substrate binding domain; Region: TilS; pfam09179 743720010724 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 743720010725 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 743720010726 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 743720010727 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 743720010728 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 743720010729 putative active site [active] 743720010730 putative PHP Thumb interface [polypeptide binding]; other site 743720010731 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 743720010732 generic binding surface II; other site 743720010733 generic binding surface I; other site 743720010734 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 743720010735 RNA/DNA hybrid binding site [nucleotide binding]; other site 743720010736 active site 743720010737 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 743720010738 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 743720010739 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 743720010740 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 743720010741 active site 743720010742 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 743720010743 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 743720010744 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 743720010745 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 743720010746 trimer interface [polypeptide binding]; other site 743720010747 active site 743720010748 UDP-GlcNAc binding site [chemical binding]; other site 743720010749 lipid binding site [chemical binding]; lipid-binding site 743720010750 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 743720010751 periplasmic chaperone; Provisional; Region: PRK10780 743720010752 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 743720010753 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 743720010754 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 743720010755 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 743720010756 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 743720010757 Surface antigen; Region: Bac_surface_Ag; pfam01103 743720010758 zinc metallopeptidase RseP; Provisional; Region: PRK10779 743720010759 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 743720010760 active site 743720010761 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 743720010762 protein binding site [polypeptide binding]; other site 743720010763 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 743720010764 protein binding site [polypeptide binding]; other site 743720010765 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 743720010766 putative substrate binding region [chemical binding]; other site 743720010767 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 743720010768 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 743720010769 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 743720010770 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 743720010771 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 743720010772 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 743720010773 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 743720010774 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 743720010775 catalytic residue [active] 743720010776 putative FPP diphosphate binding site; other site 743720010777 putative FPP binding hydrophobic cleft; other site 743720010778 dimer interface [polypeptide binding]; other site 743720010779 putative IPP diphosphate binding site; other site 743720010780 ribosome recycling factor; Reviewed; Region: frr; PRK00083 743720010781 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 743720010782 hinge region; other site 743720010783 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 743720010784 putative nucleotide binding site [chemical binding]; other site 743720010785 uridine monophosphate binding site [chemical binding]; other site 743720010786 homohexameric interface [polypeptide binding]; other site 743720010787 elongation factor Ts; Provisional; Region: tsf; PRK09377 743720010788 UBA/TS-N domain; Region: UBA; pfam00627 743720010789 Elongation factor TS; Region: EF_TS; pfam00889 743720010790 Elongation factor TS; Region: EF_TS; pfam00889 743720010791 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 743720010792 rRNA interaction site [nucleotide binding]; other site 743720010793 S8 interaction site; other site 743720010794 putative laminin-1 binding site; other site 743720010795 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 743720010796 active site 743720010797 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 743720010798 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 743720010799 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 743720010800 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 743720010801 Zn2+ binding site [ion binding]; other site 743720010802 Mg2+ binding site [ion binding]; other site 743720010803 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 743720010804 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 743720010805 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 743720010806 Cache domain; Region: Cache_1; pfam02743 743720010807 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720010808 dimerization interface [polypeptide binding]; other site 743720010809 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720010810 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720010811 dimer interface [polypeptide binding]; other site 743720010812 putative CheW interface [polypeptide binding]; other site 743720010813 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 743720010814 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743720010815 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720010816 homodimer interface [polypeptide binding]; other site 743720010817 catalytic residue [active] 743720010818 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 743720010819 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 743720010820 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720010821 S-adenosylmethionine binding site [chemical binding]; other site 743720010822 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 743720010823 dimanganese center [ion binding]; other site 743720010824 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 743720010825 dinuclear metal binding motif [ion binding]; other site 743720010826 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 743720010827 Protein of unknown function (DUF1264); Region: DUF1264; pfam06884 743720010828 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 743720010829 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 743720010830 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743720010831 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720010832 dimer interface [polypeptide binding]; other site 743720010833 phosphorylation site [posttranslational modification] 743720010834 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720010835 ATP binding site [chemical binding]; other site 743720010836 Mg2+ binding site [ion binding]; other site 743720010837 G-X-G motif; other site 743720010838 Response regulator receiver domain; Region: Response_reg; pfam00072 743720010839 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720010840 active site 743720010841 phosphorylation site [posttranslational modification] 743720010842 intermolecular recognition site; other site 743720010843 dimerization interface [polypeptide binding]; other site 743720010844 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 743720010845 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 743720010846 intersubunit interface [polypeptide binding]; other site 743720010847 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 743720010848 dimer interface [polypeptide binding]; other site 743720010849 substrate binding site [chemical binding]; other site 743720010850 ATP binding site [chemical binding]; other site 743720010851 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 743720010852 thiamine phosphate binding site [chemical binding]; other site 743720010853 active site 743720010854 pyrophosphate binding site [ion binding]; other site 743720010855 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 743720010856 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 743720010857 inhibitor-cofactor binding pocket; inhibition site 743720010858 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720010859 catalytic residue [active] 743720010860 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 743720010861 Sel1-like repeats; Region: SEL1; smart00671 743720010862 Sel1-like repeats; Region: SEL1; smart00671 743720010863 Domain of unknown function (DUF1820); Region: DUF1820; pfam08850 743720010864 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 743720010865 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 743720010866 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743720010867 FeS/SAM binding site; other site 743720010868 TRAM domain; Region: TRAM; pfam01938 743720010869 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 743720010870 PhoH-like protein; Region: PhoH; pfam02562 743720010871 metal-binding heat shock protein; Provisional; Region: PRK00016 743720010872 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 743720010873 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 743720010874 Transporter associated domain; Region: CorC_HlyC; smart01091 743720010875 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 743720010876 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 743720010877 putative active site [active] 743720010878 catalytic triad [active] 743720010879 putative dimer interface [polypeptide binding]; other site 743720010880 Uncharacterized conserved protein [Function unknown]; Region: COG1434 743720010881 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 743720010882 putative active site [active] 743720010883 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 743720010884 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 743720010885 HIGH motif; other site 743720010886 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 743720010887 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 743720010888 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 743720010889 active site 743720010890 KMSKS motif; other site 743720010891 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 743720010892 tRNA binding surface [nucleotide binding]; other site 743720010893 Lipopolysaccharide-assembly; Region: LptE; cl01125 743720010894 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 743720010895 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 743720010896 Domain of unknown function; Region: DUF331; cl01149 743720010897 Transglycosylase SLT domain; Region: SLT_2; pfam13406 743720010898 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 743720010899 N-acetyl-D-glucosamine binding site [chemical binding]; other site 743720010900 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 743720010901 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 743720010902 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 743720010903 active site 743720010904 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 743720010905 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 743720010906 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 743720010907 ArsC family; Region: ArsC; pfam03960 743720010908 putative catalytic residues [active] 743720010909 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536 743720010910 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 743720010911 putative trimer interface [polypeptide binding]; other site 743720010912 putative CoA binding site [chemical binding]; other site 743720010913 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 743720010914 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 743720010915 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 743720010916 catalytic residue [active] 743720010917 Fe-S metabolism associated domain; Region: SufE; cl00951 743720010918 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 743720010919 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 743720010920 putative ATP binding site [chemical binding]; other site 743720010921 putative substrate interface [chemical binding]; other site 743720010922 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 743720010923 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 743720010924 NdvC_like proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase; Region: CESA_NdvC_like; cd06435 743720010925 Ligand binding site; other site 743720010926 DXD motif; other site 743720010927 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 743720010928 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 743720010929 metal binding site [ion binding]; metal-binding site 743720010930 dimer interface [polypeptide binding]; other site 743720010931 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 743720010932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720010933 S-adenosylmethionine binding site [chemical binding]; other site 743720010934 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 743720010935 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 743720010936 ligand binding site [chemical binding]; other site 743720010937 homodimer interface [polypeptide binding]; other site 743720010938 NAD(P) binding site [chemical binding]; other site 743720010939 trimer interface B [polypeptide binding]; other site 743720010940 trimer interface A [polypeptide binding]; other site 743720010941 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 743720010942 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 743720010943 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 743720010944 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 743720010945 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 743720010946 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 743720010947 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 743720010948 sensor protein QseC; Provisional; Region: PRK10337 743720010949 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720010950 dimer interface [polypeptide binding]; other site 743720010951 phosphorylation site [posttranslational modification] 743720010952 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720010953 ATP binding site [chemical binding]; other site 743720010954 Mg2+ binding site [ion binding]; other site 743720010955 G-X-G motif; other site 743720010956 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 743720010957 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720010958 active site 743720010959 phosphorylation site [posttranslational modification] 743720010960 intermolecular recognition site; other site 743720010961 dimerization interface [polypeptide binding]; other site 743720010962 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743720010963 DNA binding site [nucleotide binding] 743720010964 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 743720010965 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 743720010966 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 743720010967 Sulfatase; Region: Sulfatase; cl17466 743720010968 phosphodiesterase YaeI; Provisional; Region: PRK11340 743720010969 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 743720010970 putative active site [active] 743720010971 putative metal binding site [ion binding]; other site 743720010972 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 743720010973 Ligand binding site; other site 743720010974 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 743720010975 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 743720010976 XdhC Rossmann domain; Region: XdhC_C; pfam13478 743720010977 Response regulator receiver domain; Region: Response_reg; pfam00072 743720010978 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720010979 active site 743720010980 phosphorylation site [posttranslational modification] 743720010981 intermolecular recognition site; other site 743720010982 dimerization interface [polypeptide binding]; other site 743720010983 Nitrate and nitrite sensing; Region: NIT; pfam08376 743720010984 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 743720010985 HAMP domain; Region: HAMP; pfam00672 743720010986 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720010987 dimer interface [polypeptide binding]; other site 743720010988 putative CheW interface [polypeptide binding]; other site 743720010989 Uncharacterized conserved protein [Function unknown]; Region: COG3791 743720010990 Membrane transport protein; Region: Mem_trans; cl09117 743720010991 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 743720010992 Citrate transporter; Region: CitMHS; pfam03600 743720010993 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 743720010994 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 743720010995 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 743720010996 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 743720010997 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 743720010998 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 743720010999 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 743720011000 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 743720011001 putative active site pocket [active] 743720011002 putative metal binding site [ion binding]; other site 743720011003 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 743720011004 Amidohydrolase; Region: Amidohydro_2; pfam04909 743720011005 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 743720011006 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 743720011007 Uncharacterized conserved protein [Function unknown]; Region: COG3391 743720011008 NHL repeat; Region: NHL; pfam01436 743720011009 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 743720011010 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 743720011011 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 743720011012 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 743720011013 DctM-like transporters; Region: DctM; pfam06808 743720011014 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 743720011015 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 743720011016 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 743720011017 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 743720011018 Amidohydrolase; Region: Amidohydro_2; pfam04909 743720011019 active site 743720011020 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720011021 D-galactonate transporter; Region: 2A0114; TIGR00893 743720011022 putative substrate translocation pore; other site 743720011023 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 743720011024 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 743720011025 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 743720011026 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720011027 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720011028 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720011029 dimerization interface [polypeptide binding]; other site 743720011030 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 743720011031 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 743720011032 putative acyl-acceptor binding pocket; other site 743720011033 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 743720011034 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 743720011035 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 743720011036 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 743720011037 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 743720011038 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 743720011039 HlyD family secretion protein; Region: HlyD_3; pfam13437 743720011040 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 743720011041 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 743720011042 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 743720011043 Uncharacterized conserved protein [Function unknown]; Region: COG3791 743720011044 imidazolonepropionase; Validated; Region: PRK09356 743720011045 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 743720011046 active site 743720011047 formimidoylglutamase; Provisional; Region: PRK13775 743720011048 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 743720011049 putative active site [active] 743720011050 putative metal binding site [ion binding]; other site 743720011051 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 743720011052 Nucleoside recognition; Region: Gate; pfam07670 743720011053 urocanate hydratase; Provisional; Region: PRK05414 743720011054 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 743720011055 active sites [active] 743720011056 tetramer interface [polypeptide binding]; other site 743720011057 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 743720011058 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720011059 DNA-binding site [nucleotide binding]; DNA binding site 743720011060 UTRA domain; Region: UTRA; pfam07702 743720011061 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720011062 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720011063 LysR substrate binding domain; Region: LysR_substrate; pfam03466 743720011064 dimerization interface [polypeptide binding]; other site 743720011065 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 743720011066 EamA-like transporter family; Region: EamA; pfam00892 743720011067 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 743720011068 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 743720011069 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 743720011070 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 743720011071 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 743720011072 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 743720011073 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 743720011074 catalytic loop [active] 743720011075 iron binding site [ion binding]; other site 743720011076 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 743720011077 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 743720011078 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 743720011079 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 743720011080 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 743720011081 tetramer interface [polypeptide binding]; other site 743720011082 active site 743720011083 Mg2+/Mn2+ binding site [ion binding]; other site 743720011084 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 743720011085 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 743720011086 ring oligomerisation interface [polypeptide binding]; other site 743720011087 ATP/Mg binding site [chemical binding]; other site 743720011088 stacking interactions; other site 743720011089 hinge regions; other site 743720011090 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 743720011091 oligomerisation interface [polypeptide binding]; other site 743720011092 mobile loop; other site 743720011093 roof hairpin; other site 743720011094 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 743720011095 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 743720011096 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720011097 NAD(P) binding site [chemical binding]; other site 743720011098 active site 743720011099 Protein of unknown function, DUF481; Region: DUF481; pfam04338 743720011100 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 743720011101 active site 743720011102 DNA binding site [nucleotide binding] 743720011103 muropeptide transporter; Validated; Region: ampG; cl17669 743720011104 muropeptide transporter; Validated; Region: ampG; cl17669 743720011105 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 743720011106 Conserved TM helix; Region: TM_helix; pfam05552 743720011107 Mechanosensitive ion channel; Region: MS_channel; pfam00924 743720011108 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 743720011109 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 743720011110 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 743720011111 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720011112 active site 743720011113 phosphorylation site [posttranslational modification] 743720011114 intermolecular recognition site; other site 743720011115 dimerization interface [polypeptide binding]; other site 743720011116 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743720011117 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720011118 metal binding site [ion binding]; metal-binding site 743720011119 active site 743720011120 I-site; other site 743720011121 2-dehydropantoate 2-reductase; Provisional; Region: PRK05708 743720011122 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 743720011123 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 743720011124 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720011125 dimerization interface [polypeptide binding]; other site 743720011126 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 743720011127 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720011128 dimer interface [polypeptide binding]; other site 743720011129 phosphorylation site [posttranslational modification] 743720011130 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720011131 ATP binding site [chemical binding]; other site 743720011132 Mg2+ binding site [ion binding]; other site 743720011133 G-X-G motif; other site 743720011134 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 743720011135 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 743720011136 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 743720011137 probable active site [active] 743720011138 Predicted permeases [General function prediction only]; Region: COG0679 743720011139 hypothetical protein; Provisional; Region: PRK08999 743720011140 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 743720011141 active site 743720011142 8-oxo-dGMP binding site [chemical binding]; other site 743720011143 nudix motif; other site 743720011144 metal binding site [ion binding]; metal-binding site 743720011145 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 743720011146 thiamine phosphate binding site [chemical binding]; other site 743720011147 active site 743720011148 pyrophosphate binding site [ion binding]; other site 743720011149 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 743720011150 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 743720011151 putative C-terminal domain interface [polypeptide binding]; other site 743720011152 putative GSH binding site (G-site) [chemical binding]; other site 743720011153 putative dimer interface [polypeptide binding]; other site 743720011154 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 743720011155 putative substrate binding pocket (H-site) [chemical binding]; other site 743720011156 putative N-terminal domain interface [polypeptide binding]; other site 743720011157 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 743720011158 heterotetramer interface [polypeptide binding]; other site 743720011159 active site pocket [active] 743720011160 cleavage site 743720011161 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK13103 743720011162 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 743720011163 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 743720011164 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 743720011165 nucleotide binding region [chemical binding]; other site 743720011166 ATP-binding site [chemical binding]; other site 743720011167 SEC-C motif; Region: SEC-C; pfam02810 743720011168 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 743720011169 Peptidase family M23; Region: Peptidase_M23; pfam01551 743720011170 Protein of unknown function (DUF721); Region: DUF721; pfam05258 743720011171 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 743720011172 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 743720011173 cell division protein FtsZ; Validated; Region: PRK09330 743720011174 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 743720011175 nucleotide binding site [chemical binding]; other site 743720011176 SulA interaction site; other site 743720011177 cell division protein FtsA; Region: ftsA; TIGR01174 743720011178 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 743720011179 nucleotide binding site [chemical binding]; other site 743720011180 Cell division protein FtsA; Region: FtsA; pfam14450 743720011181 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 743720011182 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 743720011183 Cell division protein FtsQ; Region: FtsQ; pfam03799 743720011184 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 743720011185 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 743720011186 ATP-grasp domain; Region: ATP-grasp_4; cl17255 743720011187 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 743720011188 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 743720011189 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 743720011190 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 743720011191 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 743720011192 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 743720011193 active site 743720011194 homodimer interface [polypeptide binding]; other site 743720011195 cell division protein FtsW; Region: ftsW; TIGR02614 743720011196 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 743720011197 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720011198 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 743720011199 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 743720011200 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 743720011201 Mg++ binding site [ion binding]; other site 743720011202 putative catalytic motif [active] 743720011203 putative substrate binding site [chemical binding]; other site 743720011204 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 743720011205 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 743720011206 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 743720011207 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 743720011208 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 743720011209 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 743720011210 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 743720011211 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 743720011212 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 743720011213 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 743720011214 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 743720011215 Cell division protein FtsL; Region: FtsL; pfam04999 743720011216 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 743720011217 MraW methylase family; Region: Methyltransf_5; cl17771 743720011218 cell division protein MraZ; Reviewed; Region: PRK00326 743720011219 MraZ protein; Region: MraZ; pfam02381 743720011220 MraZ protein; Region: MraZ; pfam02381 743720011221 Predicted methyltransferases [General function prediction only]; Region: COG0313 743720011222 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 743720011223 putative SAM binding site [chemical binding]; other site 743720011224 putative homodimer interface [polypeptide binding]; other site 743720011225 LppC putative lipoprotein; Region: LppC; pfam04348 743720011226 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 743720011227 putative ligand binding site [chemical binding]; other site 743720011228 hypothetical protein; Reviewed; Region: PRK12497 743720011229 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 743720011230 dimer interface [polypeptide binding]; other site 743720011231 active site 743720011232 BON domain; Region: BON; pfam04972 743720011233 BON domain; Region: BON; pfam04972 743720011234 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 743720011235 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 743720011236 RNase E interface [polypeptide binding]; other site 743720011237 trimer interface [polypeptide binding]; other site 743720011238 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 743720011239 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 743720011240 RNase E interface [polypeptide binding]; other site 743720011241 trimer interface [polypeptide binding]; other site 743720011242 active site 743720011243 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 743720011244 putative nucleic acid binding region [nucleotide binding]; other site 743720011245 G-X-X-G motif; other site 743720011246 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 743720011247 RNA binding site [nucleotide binding]; other site 743720011248 domain interface; other site 743720011249 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 743720011250 16S/18S rRNA binding site [nucleotide binding]; other site 743720011251 S13e-L30e interaction site [polypeptide binding]; other site 743720011252 25S rRNA binding site [nucleotide binding]; other site 743720011253 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 743720011254 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 743720011255 RNA binding site [nucleotide binding]; other site 743720011256 active site 743720011257 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 743720011258 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 743720011259 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 743720011260 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 743720011261 translation initiation factor IF-2; Region: IF-2; TIGR00487 743720011262 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 743720011263 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 743720011264 G1 box; other site 743720011265 putative GEF interaction site [polypeptide binding]; other site 743720011266 GTP/Mg2+ binding site [chemical binding]; other site 743720011267 Switch I region; other site 743720011268 G2 box; other site 743720011269 G3 box; other site 743720011270 Switch II region; other site 743720011271 G4 box; other site 743720011272 G5 box; other site 743720011273 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 743720011274 Translation-initiation factor 2; Region: IF-2; pfam11987 743720011275 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 743720011276 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 743720011277 NusA N-terminal domain; Region: NusA_N; pfam08529 743720011278 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 743720011279 RNA binding site [nucleotide binding]; other site 743720011280 homodimer interface [polypeptide binding]; other site 743720011281 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 743720011282 G-X-X-G motif; other site 743720011283 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 743720011284 G-X-X-G motif; other site 743720011285 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 743720011286 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 743720011287 ribosome maturation protein RimP; Reviewed; Region: PRK00092 743720011288 Sm and related proteins; Region: Sm_like; cl00259 743720011289 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 743720011290 putative oligomer interface [polypeptide binding]; other site 743720011291 putative RNA binding site [nucleotide binding]; other site 743720011292 Preprotein translocase SecG subunit; Region: SecG; pfam03840 743720011293 triosephosphate isomerase; Provisional; Region: PRK14567 743720011294 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 743720011295 substrate binding site [chemical binding]; other site 743720011296 dimer interface [polypeptide binding]; other site 743720011297 catalytic triad [active] 743720011298 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 743720011299 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 743720011300 active site 743720011301 substrate binding site [chemical binding]; other site 743720011302 metal binding site [ion binding]; metal-binding site 743720011303 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 743720011304 dihydropteroate synthase; Region: DHPS; TIGR01496 743720011305 substrate binding pocket [chemical binding]; other site 743720011306 dimer interface [polypeptide binding]; other site 743720011307 inhibitor binding site; inhibition site 743720011308 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 743720011309 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720011310 Walker A motif; other site 743720011311 ATP binding site [chemical binding]; other site 743720011312 Walker B motif; other site 743720011313 arginine finger; other site 743720011314 Peptidase family M41; Region: Peptidase_M41; pfam01434 743720011315 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 743720011316 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720011317 S-adenosylmethionine binding site [chemical binding]; other site 743720011318 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 743720011319 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 743720011320 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 743720011321 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 743720011322 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 743720011323 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 743720011324 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 743720011325 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 743720011326 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 743720011327 ATP-grasp domain; Region: ATP-grasp_4; cl17255 743720011328 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 743720011329 IMP binding site; other site 743720011330 dimer interface [polypeptide binding]; other site 743720011331 interdomain contacts; other site 743720011332 partial ornithine binding site; other site 743720011333 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 743720011334 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 743720011335 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 743720011336 catalytic site [active] 743720011337 subunit interface [polypeptide binding]; other site 743720011338 dihydrodipicolinate reductase; Provisional; Region: PRK00048 743720011339 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 743720011340 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 743720011341 chaperone protein DnaJ; Provisional; Region: PRK10767 743720011342 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 743720011343 HSP70 interaction site [polypeptide binding]; other site 743720011344 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 743720011345 substrate binding site [polypeptide binding]; other site 743720011346 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 743720011347 Zn binding sites [ion binding]; other site 743720011348 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 743720011349 dimer interface [polypeptide binding]; other site 743720011350 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 743720011351 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 743720011352 nucleotide binding site [chemical binding]; other site 743720011353 NEF interaction site [polypeptide binding]; other site 743720011354 SBD interface [polypeptide binding]; other site 743720011355 GrpE; Region: GrpE; pfam01025 743720011356 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 743720011357 dimer interface [polypeptide binding]; other site 743720011358 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 743720011359 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 743720011360 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 743720011361 Walker A/P-loop; other site 743720011362 ATP binding site [chemical binding]; other site 743720011363 Q-loop/lid; other site 743720011364 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 743720011365 ABC transporter signature motif; other site 743720011366 Walker B; other site 743720011367 D-loop; other site 743720011368 H-loop/switch region; other site 743720011369 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 743720011370 metal binding site 2 [ion binding]; metal-binding site 743720011371 putative DNA binding helix; other site 743720011372 metal binding site 1 [ion binding]; metal-binding site 743720011373 dimer interface [polypeptide binding]; other site 743720011374 structural Zn2+ binding site [ion binding]; other site 743720011375 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 743720011376 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 743720011377 RnfH family Ubiquitin; Region: Ub-RnfH; pfam03658 743720011378 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 743720011379 putative coenzyme Q binding site [chemical binding]; other site 743720011380 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 743720011381 SmpB-tmRNA interface; other site 743720011382 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 743720011383 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720011384 DNA-binding site [nucleotide binding]; DNA binding site 743720011385 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 743720011386 glycolate transporter; Provisional; Region: PRK09695 743720011387 L-lactate permease; Region: Lactate_perm; cl00701 743720011388 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 743720011389 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 743720011390 phosphate binding site [ion binding]; other site 743720011391 D-lactate dehydrogenase; Provisional; Region: PRK11183 743720011392 FAD binding domain; Region: FAD_binding_4; pfam01565 743720011393 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 743720011394 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 743720011395 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 743720011396 putative DNA binding site [nucleotide binding]; other site 743720011397 putative Zn2+ binding site [ion binding]; other site 743720011398 AsnC family; Region: AsnC_trans_reg; pfam01037 743720011399 Protein of unknown function (DUF2788); Region: DUF2788; pfam10981 743720011400 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 743720011401 heme-binding site [chemical binding]; other site 743720011402 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 743720011403 pseudouridine synthase; Region: TIGR00093 743720011404 active site 743720011405 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720011406 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720011407 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 743720011408 putative effector binding pocket; other site 743720011409 putative dimerization interface [polypeptide binding]; other site 743720011410 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 743720011411 homotrimer interaction site [polypeptide binding]; other site 743720011412 putative active site [active] 743720011413 lipoyl synthase; Provisional; Region: PRK05481 743720011414 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743720011415 FeS/SAM binding site; other site 743720011416 lipoate-protein ligase B; Provisional; Region: PRK14342 743720011417 hypothetical protein; Provisional; Region: PRK00341 743720011418 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 743720011419 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 743720011420 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 743720011421 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 743720011422 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 743720011423 Sporulation related domain; Region: SPOR; pfam05036 743720011424 Transglycosylase SLT domain; Region: SLT_2; pfam13406 743720011425 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 743720011426 N-acetyl-D-glucosamine binding site [chemical binding]; other site 743720011427 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 743720011428 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 743720011429 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 743720011430 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 743720011431 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 743720011432 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 743720011433 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 743720011434 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 743720011435 active site 743720011436 (T/H)XGH motif; other site 743720011437 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 743720011438 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 743720011439 putative catalytic cysteine [active] 743720011440 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 743720011441 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 743720011442 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 743720011443 active site 743720011444 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 743720011445 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 743720011446 LrgA family; Region: LrgA; cl00608 743720011447 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 743720011448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 743720011449 MORN repeat; Region: MORN; cl14787 743720011450 Peptidase C13 family; Region: Peptidase_C13; cl02159 743720011451 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 743720011452 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 743720011453 NAD binding site [chemical binding]; other site 743720011454 active site 743720011455 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 743720011456 Citrate transporter; Region: CitMHS; pfam03600 743720011457 short chain dehydrogenase; Provisional; Region: PRK08177 743720011458 C factor cell-cell signaling protein; Provisional; Region: PRK09009 743720011459 NAD(P) binding site [chemical binding]; other site 743720011460 active site 743720011461 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 743720011462 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 743720011463 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 743720011464 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 743720011465 active site 743720011466 purine riboside binding site [chemical binding]; other site 743720011467 Protein of unknown function (DUF461); Region: DUF461; pfam04314 743720011468 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 743720011469 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 743720011470 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 743720011471 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 743720011472 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 743720011473 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 743720011474 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720011475 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720011476 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 743720011477 putative effector binding pocket; other site 743720011478 dimerization interface [polypeptide binding]; other site 743720011479 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 743720011480 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 743720011481 putative NAD(P) binding site [chemical binding]; other site 743720011482 dimer interface [polypeptide binding]; other site 743720011483 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 743720011484 iron-sulfur cluster [ion binding]; other site 743720011485 [2Fe-2S] cluster binding site [ion binding]; other site 743720011486 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 743720011487 hypothetical protein; Provisional; Region: PRK08960 743720011488 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743720011489 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720011490 homodimer interface [polypeptide binding]; other site 743720011491 catalytic residue [active] 743720011492 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 743720011493 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 743720011494 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 743720011495 active site 743720011496 nucleotide binding site [chemical binding]; other site 743720011497 HIGH motif; other site 743720011498 KMSKS motif; other site 743720011499 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 743720011500 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 743720011501 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 743720011502 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 743720011503 CysD dimerization site [polypeptide binding]; other site 743720011504 G1 box; other site 743720011505 putative GEF interaction site [polypeptide binding]; other site 743720011506 GTP/Mg2+ binding site [chemical binding]; other site 743720011507 Switch I region; other site 743720011508 G2 box; other site 743720011509 G3 box; other site 743720011510 Switch II region; other site 743720011511 G4 box; other site 743720011512 G5 box; other site 743720011513 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 743720011514 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 743720011515 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 743720011516 ligand-binding site [chemical binding]; other site 743720011517 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 743720011518 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 743720011519 Active Sites [active] 743720011520 Uncharacterized conserved protein [Function unknown]; Region: COG0327 743720011521 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 743720011522 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 743720011523 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 743720011524 protein binding site [polypeptide binding]; other site 743720011525 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 743720011526 putative transposase OrfB; Reviewed; Region: PHA02517 743720011527 Integrase core domain; Region: rve; pfam00665 743720011528 Integrase core domain; Region: rve_3; pfam13683 743720011529 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 743720011530 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743720011531 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720011532 homodimer interface [polypeptide binding]; other site 743720011533 catalytic residue [active] 743720011534 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 743720011535 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 743720011536 NAD binding site [chemical binding]; other site 743720011537 dimerization interface [polypeptide binding]; other site 743720011538 product binding site; other site 743720011539 substrate binding site [chemical binding]; other site 743720011540 zinc binding site [ion binding]; other site 743720011541 catalytic residues [active] 743720011542 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 743720011543 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 743720011544 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 743720011545 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 743720011546 hinge; other site 743720011547 active site 743720011548 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 743720011549 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 743720011550 anti sigma factor interaction site; other site 743720011551 regulatory phosphorylation site [posttranslational modification]; other site 743720011552 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 743720011553 mce related protein; Region: MCE; pfam02470 743720011554 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 743720011555 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 743720011556 Permease; Region: Permease; cl00510 743720011557 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 743720011558 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 743720011559 Walker A/P-loop; other site 743720011560 ATP binding site [chemical binding]; other site 743720011561 Q-loop/lid; other site 743720011562 ABC transporter signature motif; other site 743720011563 Walker B; other site 743720011564 D-loop; other site 743720011565 H-loop/switch region; other site 743720011566 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 743720011567 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 743720011568 putative active site [active] 743720011569 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 743720011570 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 743720011571 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743720011572 active site 743720011573 motif I; other site 743720011574 motif II; other site 743720011575 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 743720011576 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 743720011577 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 743720011578 OstA-like protein; Region: OstA; pfam03968 743720011579 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 743720011580 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 743720011581 Walker A/P-loop; other site 743720011582 ATP binding site [chemical binding]; other site 743720011583 Q-loop/lid; other site 743720011584 ABC transporter signature motif; other site 743720011585 Walker B; other site 743720011586 D-loop; other site 743720011587 H-loop/switch region; other site 743720011588 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 743720011589 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 743720011590 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 743720011591 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 743720011592 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 743720011593 30S subunit binding site; other site 743720011594 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 743720011595 active site 743720011596 phosphorylation site [posttranslational modification] 743720011597 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 743720011598 AAA domain; Region: AAA_18; pfam13238 743720011599 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 743720011600 dimerization domain swap beta strand [polypeptide binding]; other site 743720011601 regulatory protein interface [polypeptide binding]; other site 743720011602 active site 743720011603 regulatory phosphorylation site [posttranslational modification]; other site 743720011604 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 743720011605 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 743720011606 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 743720011607 fumarate hydratase; Reviewed; Region: fumC; PRK00485 743720011608 Class II fumarases; Region: Fumarase_classII; cd01362 743720011609 active site 743720011610 tetramer interface [polypeptide binding]; other site 743720011611 peptidase PmbA; Provisional; Region: PRK11040 743720011612 hypothetical protein; Provisional; Region: PRK05255 743720011613 protease TldD; Provisional; Region: tldD; PRK10735 743720011614 nitrilase; Region: PLN02798 743720011615 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 743720011616 putative active site [active] 743720011617 catalytic triad [active] 743720011618 dimer interface [polypeptide binding]; other site 743720011619 TIGR02099 family protein; Region: TIGR02099 743720011620 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 743720011621 ribonuclease G; Provisional; Region: PRK11712 743720011622 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 743720011623 homodimer interface [polypeptide binding]; other site 743720011624 oligonucleotide binding site [chemical binding]; other site 743720011625 Maf-like protein; Region: Maf; pfam02545 743720011626 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 743720011627 active site 743720011628 dimer interface [polypeptide binding]; other site 743720011629 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 743720011630 rod shape-determining protein MreC; Provisional; Region: PRK13922 743720011631 rod shape-determining protein MreC; Region: MreC; pfam04085 743720011632 rod shape-determining protein MreB; Provisional; Region: PRK13927 743720011633 MreB and similar proteins; Region: MreB_like; cd10225 743720011634 nucleotide binding site [chemical binding]; other site 743720011635 Mg binding site [ion binding]; other site 743720011636 putative protofilament interaction site [polypeptide binding]; other site 743720011637 RodZ interaction site [polypeptide binding]; other site 743720011638 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 743720011639 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 743720011640 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 743720011641 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 743720011642 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 743720011643 GatB domain; Region: GatB_Yqey; smart00845 743720011644 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 743720011645 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 743720011646 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720011647 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720011648 LysR substrate binding domain; Region: LysR_substrate; pfam03466 743720011649 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 743720011650 HPP family; Region: HPP; pfam04982 743720011651 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 743720011652 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 743720011653 Predicted secreted protein [Function unknown]; Region: COG5445 743720011654 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 743720011655 Predicted secreted protein [Function unknown]; Region: COG5445 743720011656 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 743720011657 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 743720011658 MG2 domain; Region: A2M_N; pfam01835 743720011659 Alpha-2-macroglobulin family; Region: A2M; pfam00207 743720011660 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 743720011661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 743720011662 hypothetical protein; Provisional; Region: PRK11410 743720011663 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 743720011664 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 743720011665 Predicted permeases [General function prediction only]; Region: COG0679 743720011666 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 743720011667 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720011668 active site 743720011669 phosphorylation site [posttranslational modification] 743720011670 intermolecular recognition site; other site 743720011671 dimerization interface [polypeptide binding]; other site 743720011672 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 743720011673 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743720011674 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720011675 ATP binding site [chemical binding]; other site 743720011676 G-X-G motif; other site 743720011677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720011678 D-galactonate transporter; Region: 2A0114; TIGR00893 743720011679 putative substrate translocation pore; other site 743720011680 Protein of unknown function (DUF541); Region: SIMPL; cl01077 743720011681 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 743720011682 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 743720011683 peptide binding site [polypeptide binding]; other site 743720011684 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 743720011685 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 743720011686 peptide binding site [polypeptide binding]; other site 743720011687 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 743720011688 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 743720011689 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 743720011690 active site 743720011691 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 743720011692 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 743720011693 non-specific DNA binding site [nucleotide binding]; other site 743720011694 salt bridge; other site 743720011695 sequence-specific DNA binding site [nucleotide binding]; other site 743720011696 Cupin domain; Region: Cupin_2; pfam07883 743720011697 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 743720011698 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 743720011699 peptide binding site [polypeptide binding]; other site 743720011700 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 743720011701 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 743720011702 peptide binding site [polypeptide binding]; other site 743720011703 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 743720011704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720011705 dimer interface [polypeptide binding]; other site 743720011706 conserved gate region; other site 743720011707 putative PBP binding loops; other site 743720011708 ABC-ATPase subunit interface; other site 743720011709 dipeptide transporter; Provisional; Region: PRK10913 743720011710 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 743720011711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720011712 dimer interface [polypeptide binding]; other site 743720011713 conserved gate region; other site 743720011714 putative PBP binding loops; other site 743720011715 ABC-ATPase subunit interface; other site 743720011716 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 743720011717 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 743720011718 Walker A/P-loop; other site 743720011719 ATP binding site [chemical binding]; other site 743720011720 Q-loop/lid; other site 743720011721 ABC transporter signature motif; other site 743720011722 Walker B; other site 743720011723 D-loop; other site 743720011724 H-loop/switch region; other site 743720011725 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 743720011726 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 743720011727 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 743720011728 Walker A/P-loop; other site 743720011729 ATP binding site [chemical binding]; other site 743720011730 Q-loop/lid; other site 743720011731 ABC transporter signature motif; other site 743720011732 Walker B; other site 743720011733 D-loop; other site 743720011734 H-loop/switch region; other site 743720011735 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 743720011736 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 743720011737 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 743720011738 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 743720011739 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 743720011740 Flavodoxin; Region: Flavodoxin_1; pfam00258 743720011741 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 743720011742 FAD binding pocket [chemical binding]; other site 743720011743 FAD binding motif [chemical binding]; other site 743720011744 catalytic residues [active] 743720011745 NAD binding pocket [chemical binding]; other site 743720011746 phosphate binding motif [ion binding]; other site 743720011747 beta-alpha-beta structure motif; other site 743720011748 glutamate dehydrogenase; Provisional; Region: PRK09414 743720011749 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 743720011750 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 743720011751 NAD(P) binding site [chemical binding]; other site 743720011752 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 743720011753 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 743720011754 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720011755 Walker A motif; other site 743720011756 ATP binding site [chemical binding]; other site 743720011757 Walker B motif; other site 743720011758 arginine finger; other site 743720011759 TROVE domain; Region: TROVE; pfam05731 743720011760 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 743720011761 hypothetical protein; Reviewed; Region: PRK09588 743720011762 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 743720011763 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 743720011764 RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874 743720011765 putative active site [active] 743720011766 adenylation catalytic residue [active] 743720011767 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 743720011768 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 743720011769 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 743720011770 ABC transporter; Region: ABC_tran_2; pfam12848 743720011771 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 743720011772 PAS domain; Region: PAS_9; pfam13426 743720011773 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720011774 PAS fold; Region: PAS_3; pfam08447 743720011775 putative active site [active] 743720011776 heme pocket [chemical binding]; other site 743720011777 PAS domain S-box; Region: sensory_box; TIGR00229 743720011778 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720011779 putative active site [active] 743720011780 heme pocket [chemical binding]; other site 743720011781 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720011782 PAS domain; Region: PAS_9; pfam13426 743720011783 putative active site [active] 743720011784 heme pocket [chemical binding]; other site 743720011785 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743720011786 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720011787 metal binding site [ion binding]; metal-binding site 743720011788 active site 743720011789 I-site; other site 743720011790 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743720011791 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 743720011792 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 743720011793 dimer interface [polypeptide binding]; other site 743720011794 active site 743720011795 glycine-pyridoxal phosphate binding site [chemical binding]; other site 743720011796 folate binding site [chemical binding]; other site 743720011797 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743720011798 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720011799 dimer interface [polypeptide binding]; other site 743720011800 phosphorylation site [posttranslational modification] 743720011801 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720011802 ATP binding site [chemical binding]; other site 743720011803 Mg2+ binding site [ion binding]; other site 743720011804 G-X-G motif; other site 743720011805 Response regulator receiver domain; Region: Response_reg; pfam00072 743720011806 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720011807 active site 743720011808 phosphorylation site [posttranslational modification] 743720011809 intermolecular recognition site; other site 743720011810 dimerization interface [polypeptide binding]; other site 743720011811 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 743720011812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720011813 active site 743720011814 phosphorylation site [posttranslational modification] 743720011815 intermolecular recognition site; other site 743720011816 dimerization interface [polypeptide binding]; other site 743720011817 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 743720011818 DNA binding residues [nucleotide binding] 743720011819 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 743720011820 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 743720011821 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720011822 S-adenosylmethionine binding site [chemical binding]; other site 743720011823 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 743720011824 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 743720011825 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 743720011826 Nuclease-related domain; Region: NERD; pfam08378 743720011827 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 743720011828 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 743720011829 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 743720011830 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 743720011831 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 743720011832 TM-ABC transporter signature motif; other site 743720011833 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 743720011834 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 743720011835 TM-ABC transporter signature motif; other site 743720011836 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 743720011837 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 743720011838 Walker A/P-loop; other site 743720011839 ATP binding site [chemical binding]; other site 743720011840 Q-loop/lid; other site 743720011841 ABC transporter signature motif; other site 743720011842 Walker B; other site 743720011843 D-loop; other site 743720011844 H-loop/switch region; other site 743720011845 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 743720011846 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 743720011847 Walker A/P-loop; other site 743720011848 ATP binding site [chemical binding]; other site 743720011849 Q-loop/lid; other site 743720011850 ABC transporter signature motif; other site 743720011851 Walker B; other site 743720011852 D-loop; other site 743720011853 H-loop/switch region; other site 743720011854 amidase; Provisional; Region: PRK07235 743720011855 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 743720011856 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 743720011857 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 743720011858 ligand binding site [chemical binding]; other site 743720011859 regulator interaction site; other site 743720011860 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 743720011861 ANTAR domain; Region: ANTAR; pfam03861 743720011862 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 743720011863 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 743720011864 inhibitor-cofactor binding pocket; inhibition site 743720011865 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720011866 catalytic residue [active] 743720011867 succinic semialdehyde dehydrogenase; Region: PLN02278 743720011868 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 743720011869 tetramerization interface [polypeptide binding]; other site 743720011870 NAD(P) binding site [chemical binding]; other site 743720011871 catalytic residues [active] 743720011872 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 743720011873 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720011874 DNA-binding site [nucleotide binding]; DNA binding site 743720011875 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 743720011876 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720011877 homodimer interface [polypeptide binding]; other site 743720011878 catalytic residue [active] 743720011879 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 743720011880 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 743720011881 PYR/PP interface [polypeptide binding]; other site 743720011882 dimer interface [polypeptide binding]; other site 743720011883 TPP binding site [chemical binding]; other site 743720011884 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 743720011885 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 743720011886 TPP-binding site [chemical binding]; other site 743720011887 dimer interface [polypeptide binding]; other site 743720011888 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720011889 D-galactonate transporter; Region: 2A0114; TIGR00893 743720011890 putative substrate translocation pore; other site 743720011891 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 743720011892 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 743720011893 NAD(P) binding site [chemical binding]; other site 743720011894 active site 743720011895 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 743720011896 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720011897 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 743720011898 dimerization interface [polypeptide binding]; other site 743720011899 substrate binding pocket [chemical binding]; other site 743720011900 Cache domain; Region: Cache_1; pfam02743 743720011901 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743720011902 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720011903 metal binding site [ion binding]; metal-binding site 743720011904 active site 743720011905 I-site; other site 743720011906 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 743720011907 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 743720011908 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 743720011909 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 743720011910 NAD binding site [chemical binding]; other site 743720011911 homotetramer interface [polypeptide binding]; other site 743720011912 homodimer interface [polypeptide binding]; other site 743720011913 active site 743720011914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720011915 D-galactonate transporter; Region: 2A0114; TIGR00893 743720011916 putative substrate translocation pore; other site 743720011917 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720011918 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720011919 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 743720011920 putative dimerization interface [polypeptide binding]; other site 743720011921 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 743720011922 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 743720011923 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 743720011924 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 743720011925 DNA topoisomerase III; Provisional; Region: PRK07726 743720011926 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 743720011927 active site 743720011928 putative interdomain interaction site [polypeptide binding]; other site 743720011929 putative metal-binding site [ion binding]; other site 743720011930 putative nucleotide binding site [chemical binding]; other site 743720011931 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 743720011932 domain I; other site 743720011933 DNA binding groove [nucleotide binding] 743720011934 phosphate binding site [ion binding]; other site 743720011935 domain II; other site 743720011936 domain III; other site 743720011937 nucleotide binding site [chemical binding]; other site 743720011938 catalytic site [active] 743720011939 domain IV; other site 743720011940 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 743720011941 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 743720011942 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 743720011943 substrate binding pocket [chemical binding]; other site 743720011944 chain length determination region; other site 743720011945 substrate-Mg2+ binding site; other site 743720011946 catalytic residues [active] 743720011947 aspartate-rich region 1; other site 743720011948 active site lid residues [active] 743720011949 aspartate-rich region 2; other site 743720011950 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 743720011951 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 743720011952 TPP-binding site; other site 743720011953 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 743720011954 PYR/PP interface [polypeptide binding]; other site 743720011955 dimer interface [polypeptide binding]; other site 743720011956 TPP binding site [chemical binding]; other site 743720011957 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 743720011958 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720011959 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720011960 dimer interface [polypeptide binding]; other site 743720011961 putative CheW interface [polypeptide binding]; other site 743720011962 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 743720011963 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 743720011964 dimerization interface [polypeptide binding]; other site 743720011965 active site 743720011966 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 743720011967 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 743720011968 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 743720011969 G1 box; other site 743720011970 putative GEF interaction site [polypeptide binding]; other site 743720011971 GTP/Mg2+ binding site [chemical binding]; other site 743720011972 Switch I region; other site 743720011973 G2 box; other site 743720011974 G3 box; other site 743720011975 Switch II region; other site 743720011976 G4 box; other site 743720011977 G5 box; other site 743720011978 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 743720011979 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 743720011980 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 743720011981 Trp docking motif [polypeptide binding]; other site 743720011982 putative active site [active] 743720011983 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 743720011984 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 743720011985 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 743720011986 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 743720011987 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 743720011988 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 743720011989 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 743720011990 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 743720011991 active site 743720011992 Methyltransferase domain; Region: Methyltransf_23; pfam13489 743720011993 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720011994 S-adenosylmethionine binding site [chemical binding]; other site 743720011995 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 743720011996 active site 743720011997 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 743720011998 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 743720011999 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 743720012000 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 743720012001 Ligand binding site; other site 743720012002 Putative Catalytic site; other site 743720012003 DXD motif; other site 743720012004 tetratricopeptide repeat protein; Provisional; Region: PRK11788 743720012005 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 743720012006 Pilin (bacterial filament); Region: Pilin; pfam00114 743720012007 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 743720012008 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 743720012009 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 743720012010 Walker A motif; other site 743720012011 ATP binding site [chemical binding]; other site 743720012012 Walker B motif; other site 743720012013 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 743720012014 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 743720012015 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 743720012016 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 743720012017 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 743720012018 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 743720012019 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 743720012020 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 743720012021 CoA-binding site [chemical binding]; other site 743720012022 ATP-binding [chemical binding]; other site 743720012023 DNA gyrase inhibitor; Reviewed; Region: PRK00418 743720012024 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 743720012025 MOSC domain; Region: MOSC; pfam03473 743720012026 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 743720012027 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 743720012028 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793 743720012029 PilZ domain; Region: PilZ; pfam07238 743720012030 Uncharacterized protein required for formate dehydrogenase activity [Energy production and conversion]; Region: FdhD; COG1526 743720012031 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 743720012032 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 743720012033 putative molybdopterin cofactor binding site [chemical binding]; other site 743720012034 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 743720012035 putative molybdopterin cofactor binding site; other site 743720012036 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 743720012037 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 743720012038 active site 743720012039 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 743720012040 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 743720012041 active site 743720012042 NAD binding site [chemical binding]; other site 743720012043 metal binding site [ion binding]; metal-binding site 743720012044 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 743720012045 30S subunit binding site; other site 743720012046 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 743720012047 dimer interface [polypeptide binding]; other site 743720012048 FMN binding site [chemical binding]; other site 743720012049 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 743720012050 Permease; Region: Permease; pfam02405 743720012051 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 743720012052 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743720012053 Walker A/P-loop; other site 743720012054 ATP binding site [chemical binding]; other site 743720012055 Q-loop/lid; other site 743720012056 ABC transporter signature motif; other site 743720012057 Walker B; other site 743720012058 D-loop; other site 743720012059 H-loop/switch region; other site 743720012060 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 743720012061 mce related protein; Region: MCE; pfam02470 743720012062 Protein of unknown function (DUF330); Region: DUF330; cl01135 743720012063 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 743720012064 Clp amino terminal domain; Region: Clp_N; pfam02861 743720012065 Clp amino terminal domain; Region: Clp_N; pfam02861 743720012066 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720012067 Walker A motif; other site 743720012068 ATP binding site [chemical binding]; other site 743720012069 Walker B motif; other site 743720012070 arginine finger; other site 743720012071 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720012072 Walker A motif; other site 743720012073 ATP binding site [chemical binding]; other site 743720012074 Walker B motif; other site 743720012075 arginine finger; other site 743720012076 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 743720012077 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 743720012078 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 743720012079 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 743720012080 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 743720012081 RNA binding surface [nucleotide binding]; other site 743720012082 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 743720012083 active site 743720012084 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 743720012085 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743720012086 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720012087 dimer interface [polypeptide binding]; other site 743720012088 phosphorylation site [posttranslational modification] 743720012089 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720012090 ATP binding site [chemical binding]; other site 743720012091 Mg2+ binding site [ion binding]; other site 743720012092 G-X-G motif; other site 743720012093 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 743720012094 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720012095 active site 743720012096 phosphorylation site [posttranslational modification] 743720012097 intermolecular recognition site; other site 743720012098 dimerization interface [polypeptide binding]; other site 743720012099 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720012100 Walker A motif; other site 743720012101 ATP binding site [chemical binding]; other site 743720012102 Walker B motif; other site 743720012103 arginine finger; other site 743720012104 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 743720012105 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 743720012106 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 743720012107 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 743720012108 Type II transport protein GspH; Region: GspH; pfam12019 743720012109 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 743720012110 Type II transport protein GspH; Region: GspH; pfam12019 743720012111 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 743720012112 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 743720012113 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 743720012114 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 743720012115 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 743720012116 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 743720012117 Tubulin like; Region: Tubulin_2; pfam13809 743720012118 Transcriptional regulators [Transcription]; Region: FadR; COG2186 743720012119 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720012120 DNA-binding site [nucleotide binding]; DNA binding site 743720012121 FCD domain; Region: FCD; pfam07729 743720012122 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 743720012123 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 743720012124 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 743720012125 Walker A/P-loop; other site 743720012126 ATP binding site [chemical binding]; other site 743720012127 Q-loop/lid; other site 743720012128 ABC transporter signature motif; other site 743720012129 Walker B; other site 743720012130 D-loop; other site 743720012131 H-loop/switch region; other site 743720012132 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 743720012133 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 743720012134 Walker A/P-loop; other site 743720012135 ATP binding site [chemical binding]; other site 743720012136 Q-loop/lid; other site 743720012137 ABC transporter signature motif; other site 743720012138 Walker B; other site 743720012139 D-loop; other site 743720012140 H-loop/switch region; other site 743720012141 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 743720012142 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 743720012143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720012144 dimer interface [polypeptide binding]; other site 743720012145 conserved gate region; other site 743720012146 ABC-ATPase subunit interface; other site 743720012147 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 743720012148 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 743720012149 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 743720012150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720012151 dimer interface [polypeptide binding]; other site 743720012152 conserved gate region; other site 743720012153 putative PBP binding loops; other site 743720012154 ABC-ATPase subunit interface; other site 743720012155 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 743720012156 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 743720012157 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 743720012158 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 4. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_4; cd03329 743720012159 putative active site pocket [active] 743720012160 metal binding site [ion binding]; metal-binding site 743720012161 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 743720012162 Predicted flavoprotein [General function prediction only]; Region: COG0431 743720012163 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 743720012164 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 743720012165 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 743720012166 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 743720012167 active site 743720012168 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 743720012169 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743720012170 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720012171 metal binding site [ion binding]; metal-binding site 743720012172 active site 743720012173 I-site; other site 743720012174 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 743720012175 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 743720012176 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 743720012177 active site 743720012178 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 743720012179 SprA-related family; Region: SprA-related; pfam12118 743720012180 Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749 743720012181 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 743720012182 AAA domain; Region: AAA_26; pfam13500 743720012183 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 743720012184 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720012185 S-adenosylmethionine binding site [chemical binding]; other site 743720012186 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 743720012187 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 743720012188 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 743720012189 substrate-cofactor binding pocket; other site 743720012190 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720012191 catalytic residue [active] 743720012192 biotin synthase; Provisional; Region: PRK15108 743720012193 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743720012194 FeS/SAM binding site; other site 743720012195 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 743720012196 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 743720012197 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 743720012198 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 743720012199 TOBE domain; Region: TOBE; cl01440 743720012200 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 743720012201 serine/threonine protein kinase; Provisional; Region: PRK11768 743720012202 Predicted permeases [General function prediction only]; Region: RarD; COG2962 743720012203 EamA-like transporter family; Region: EamA; pfam00892 743720012204 EamA-like transporter family; Region: EamA; pfam00892 743720012205 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 743720012206 ACT domain; Region: ACT_6; pfam13740 743720012207 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 743720012208 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 743720012209 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720012210 Coenzyme A binding pocket [chemical binding]; other site 743720012211 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 743720012212 active site 743720012213 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 743720012214 Acyltransferase family; Region: Acyl_transf_3; pfam01757 743720012215 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 743720012216 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 743720012217 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 743720012218 ligand binding site [chemical binding]; other site 743720012219 flexible hinge region; other site 743720012220 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 743720012221 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 743720012222 metal binding triad; other site 743720012223 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 743720012224 active site 743720012225 catalytic site [active] 743720012226 substrate binding site [chemical binding]; other site 743720012227 putative protease; Provisional; Region: PRK15452 743720012228 Peptidase family U32; Region: Peptidase_U32; pfam01136 743720012229 inner membrane protein; Provisional; Region: PRK11715 743720012230 FOG: CBS domain [General function prediction only]; Region: COG0517 743720012231 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 743720012232 sensory histidine kinase CreC; Provisional; Region: PRK11100 743720012233 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 743720012234 dimerization interface [polypeptide binding]; other site 743720012235 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720012236 dimer interface [polypeptide binding]; other site 743720012237 phosphorylation site [posttranslational modification] 743720012238 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720012239 ATP binding site [chemical binding]; other site 743720012240 Mg2+ binding site [ion binding]; other site 743720012241 G-X-G motif; other site 743720012242 DNA-binding response regulator CreB; Provisional; Region: PRK11083 743720012243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720012244 active site 743720012245 phosphorylation site [posttranslational modification] 743720012246 intermolecular recognition site; other site 743720012247 dimerization interface [polypeptide binding]; other site 743720012248 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743720012249 DNA binding site [nucleotide binding] 743720012250 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 743720012251 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720012252 dimer interface [polypeptide binding]; other site 743720012253 putative CheW interface [polypeptide binding]; other site 743720012254 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 743720012255 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 743720012256 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 743720012257 Walker A/P-loop; other site 743720012258 ATP binding site [chemical binding]; other site 743720012259 Q-loop/lid; other site 743720012260 ABC transporter signature motif; other site 743720012261 Walker B; other site 743720012262 D-loop; other site 743720012263 H-loop/switch region; other site 743720012264 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720012265 dimer interface [polypeptide binding]; other site 743720012266 conserved gate region; other site 743720012267 putative PBP binding loops; other site 743720012268 ABC-ATPase subunit interface; other site 743720012269 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720012270 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 743720012271 substrate binding pocket [chemical binding]; other site 743720012272 membrane-bound complex binding site; other site 743720012273 hinge residues; other site 743720012274 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 743720012275 putative active site [active] 743720012276 dimerization interface [polypeptide binding]; other site 743720012277 putative tRNAtyr binding site [nucleotide binding]; other site 743720012278 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 743720012279 TAP-like protein; Region: Abhydrolase_4; pfam08386 743720012280 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 743720012281 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 743720012282 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 743720012283 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 743720012284 fructose-1,6-bisphosphatase family protein; Region: PLN02628 743720012285 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 743720012286 AMP binding site [chemical binding]; other site 743720012287 metal binding site [ion binding]; metal-binding site 743720012288 active site 743720012289 PAS fold; Region: PAS_4; pfam08448 743720012290 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720012291 putative active site [active] 743720012292 heme pocket [chemical binding]; other site 743720012293 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743720012294 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720012295 metal binding site [ion binding]; metal-binding site 743720012296 active site 743720012297 I-site; other site 743720012298 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 743720012299 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 743720012300 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 743720012301 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 743720012302 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 743720012303 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 743720012304 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 743720012305 Substrate binding site; other site 743720012306 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 743720012307 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 743720012308 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 743720012309 active site 743720012310 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 743720012311 PilZ domain; Region: PilZ; pfam07238 743720012312 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 743720012313 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 743720012314 Alginate O-acetyl transferase AlgF; Region: AlgF; pfam11182 743720012315 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 743720012316 active site 743720012317 Right handed beta helix region; Region: Beta_helix; pfam13229 743720012318 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 743720012319 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 743720012320 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 743720012321 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 743720012322 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 743720012323 G1 box; other site 743720012324 putative GEF interaction site [polypeptide binding]; other site 743720012325 GTP/Mg2+ binding site [chemical binding]; other site 743720012326 Switch I region; other site 743720012327 G2 box; other site 743720012328 G3 box; other site 743720012329 Switch II region; other site 743720012330 G4 box; other site 743720012331 G5 box; other site 743720012332 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 743720012333 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 743720012334 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 743720012335 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 743720012336 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 743720012337 Ligand Binding Site [chemical binding]; other site 743720012338 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 743720012339 active site residue [active] 743720012340 glutamine synthetase; Provisional; Region: glnA; PRK09469 743720012341 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 743720012342 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 743720012343 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 743720012344 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 743720012345 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 743720012346 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720012347 dimer interface [polypeptide binding]; other site 743720012348 phosphorylation site [posttranslational modification] 743720012349 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720012350 ATP binding site [chemical binding]; other site 743720012351 Mg2+ binding site [ion binding]; other site 743720012352 G-X-G motif; other site 743720012353 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 743720012354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720012355 active site 743720012356 phosphorylation site [posttranslational modification] 743720012357 intermolecular recognition site; other site 743720012358 dimerization interface [polypeptide binding]; other site 743720012359 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720012360 Walker A motif; other site 743720012361 ATP binding site [chemical binding]; other site 743720012362 Walker B motif; other site 743720012363 arginine finger; other site 743720012364 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 743720012365 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 743720012366 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 743720012367 SecA binding site; other site 743720012368 Preprotein binding site; other site 743720012369 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 743720012370 GSH binding site [chemical binding]; other site 743720012371 catalytic residues [active] 743720012372 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 743720012373 active site residue [active] 743720012374 phosphoglyceromutase; Provisional; Region: PRK05434 743720012375 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 743720012376 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 743720012377 Peptidase family M23; Region: Peptidase_M23; pfam01551 743720012378 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 743720012379 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 743720012380 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 743720012381 protein binding site [polypeptide binding]; other site 743720012382 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 743720012383 Catalytic dyad [active] 743720012384 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 743720012385 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720012386 substrate binding pocket [chemical binding]; other site 743720012387 membrane-bound complex binding site; other site 743720012388 hinge residues; other site 743720012389 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720012390 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 743720012391 substrate binding pocket [chemical binding]; other site 743720012392 membrane-bound complex binding site; other site 743720012393 hinge residues; other site 743720012394 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 743720012395 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 743720012396 Walker A/P-loop; other site 743720012397 ATP binding site [chemical binding]; other site 743720012398 Q-loop/lid; other site 743720012399 ABC transporter signature motif; other site 743720012400 Walker B; other site 743720012401 D-loop; other site 743720012402 H-loop/switch region; other site 743720012403 HlyD family secretion protein; Region: HlyD; pfam00529 743720012404 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 743720012405 HlyD family secretion protein; Region: HlyD_3; pfam13437 743720012406 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 743720012407 Methyltransferase domain; Region: Methyltransf_23; pfam13489 743720012408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720012409 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 743720012410 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743720012411 binding surface 743720012412 TPR motif; other site 743720012413 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 743720012414 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 743720012415 substrate binding site [chemical binding]; other site 743720012416 glutamase interaction surface [polypeptide binding]; other site 743720012417 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 743720012418 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 743720012419 catalytic residues [active] 743720012420 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 743720012421 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 743720012422 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 743720012423 putative active site [active] 743720012424 oxyanion strand; other site 743720012425 catalytic triad [active] 743720012426 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 743720012427 putative active site pocket [active] 743720012428 4-fold oligomerization interface [polypeptide binding]; other site 743720012429 metal binding residues [ion binding]; metal-binding site 743720012430 3-fold/trimer interface [polypeptide binding]; other site 743720012431 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 743720012432 AsmA family; Region: AsmA; pfam05170 743720012433 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 743720012434 adenine DNA glycosylase; Provisional; Region: PRK10880 743720012435 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 743720012436 minor groove reading motif; other site 743720012437 helix-hairpin-helix signature motif; other site 743720012438 substrate binding pocket [chemical binding]; other site 743720012439 active site 743720012440 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 743720012441 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 743720012442 DNA binding and oxoG recognition site [nucleotide binding] 743720012443 oxidative damage protection protein; Provisional; Region: PRK05408 743720012444 phosphoglycolate phosphatase; Provisional; Region: PRK13222 743720012445 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743720012446 motif II; other site 743720012447 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 743720012448 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 743720012449 substrate binding site [chemical binding]; other site 743720012450 hexamer interface [polypeptide binding]; other site 743720012451 metal binding site [ion binding]; metal-binding site 743720012452 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 743720012453 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 743720012454 active site 743720012455 NAD binding site [chemical binding]; other site 743720012456 metal binding site [ion binding]; metal-binding site 743720012457 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720012458 PAS domain; Region: PAS_9; pfam13426 743720012459 putative active site [active] 743720012460 heme pocket [chemical binding]; other site 743720012461 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720012462 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 743720012463 Walker A motif; other site 743720012464 ATP binding site [chemical binding]; other site 743720012465 Walker B motif; other site 743720012466 arginine finger; other site 743720012467 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 743720012468 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 743720012469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720012470 dimer interface [polypeptide binding]; other site 743720012471 conserved gate region; other site 743720012472 putative PBP binding loops; other site 743720012473 ABC-ATPase subunit interface; other site 743720012474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720012475 dimer interface [polypeptide binding]; other site 743720012476 conserved gate region; other site 743720012477 putative PBP binding loops; other site 743720012478 ABC-ATPase subunit interface; other site 743720012479 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 743720012480 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 743720012481 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 743720012482 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 743720012483 Walker A/P-loop; other site 743720012484 ATP binding site [chemical binding]; other site 743720012485 Q-loop/lid; other site 743720012486 ABC transporter signature motif; other site 743720012487 Walker B; other site 743720012488 D-loop; other site 743720012489 H-loop/switch region; other site 743720012490 TOBE domain; Region: TOBE_2; pfam08402 743720012491 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 743720012492 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720012493 active site 743720012494 phosphorylation site [posttranslational modification] 743720012495 intermolecular recognition site; other site 743720012496 dimerization interface [polypeptide binding]; other site 743720012497 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 743720012498 DNA binding residues [nucleotide binding] 743720012499 dimerization interface [polypeptide binding]; other site 743720012500 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 743720012501 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720012502 substrate binding pocket [chemical binding]; other site 743720012503 membrane-bound complex binding site; other site 743720012504 hinge residues; other site 743720012505 PAS domain; Region: PAS_9; pfam13426 743720012506 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720012507 putative active site [active] 743720012508 heme pocket [chemical binding]; other site 743720012509 PAS fold; Region: PAS_3; pfam08447 743720012510 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 743720012511 Histidine kinase; Region: HisKA_3; pfam07730 743720012512 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720012513 ATP binding site [chemical binding]; other site 743720012514 Mg2+ binding site [ion binding]; other site 743720012515 G-X-G motif; other site 743720012516 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 743720012517 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 743720012518 putative metal binding site [ion binding]; other site 743720012519 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 743720012520 HSP70 interaction site [polypeptide binding]; other site 743720012521 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 743720012522 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 743720012523 Substrate binding site; other site 743720012524 metal-binding site 743720012525 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 743720012526 Phosphotransferase enzyme family; Region: APH; pfam01636 743720012527 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 743720012528 OstA-like protein; Region: OstA; cl00844 743720012529 Organic solvent tolerance protein; Region: OstA_C; pfam04453 743720012530 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 743720012531 SurA N-terminal domain; Region: SurA_N; pfam09312 743720012532 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 743720012533 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 743720012534 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 743720012535 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 743720012536 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 743720012537 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 743720012538 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 743720012539 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 743720012540 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 743720012541 active site 743720012542 metal binding site [ion binding]; metal-binding site 743720012543 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 743720012544 active site residue [active] 743720012545 PrkA family serine protein kinase; Provisional; Region: PRK15455 743720012546 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 743720012547 hypothetical protein; Provisional; Region: PRK05325 743720012548 SpoVR family protein; Provisional; Region: PRK11767 743720012549 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 743720012550 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 743720012551 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 743720012552 active site 743720012553 NTP binding site [chemical binding]; other site 743720012554 metal binding triad [ion binding]; metal-binding site 743720012555 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 743720012556 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 743720012557 Zn2+ binding site [ion binding]; other site 743720012558 Mg2+ binding site [ion binding]; other site 743720012559 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 743720012560 catalytic center binding site [active] 743720012561 ATP binding site [chemical binding]; other site 743720012562 Dihydroneopterin aldolase; Region: FolB; smart00905 743720012563 active site 743720012564 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 743720012565 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 743720012566 UGMP family protein; Validated; Region: PRK09604 743720012567 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 743720012568 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 743720012569 DNA primase, catalytic core; Region: dnaG; TIGR01391 743720012570 CHC2 zinc finger; Region: zf-CHC2; pfam01807 743720012571 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 743720012572 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 743720012573 active site 743720012574 metal binding site [ion binding]; metal-binding site 743720012575 interdomain interaction site; other site 743720012576 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 743720012577 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 743720012578 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 743720012579 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 743720012580 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 743720012581 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 743720012582 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743720012583 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 743720012584 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743720012585 DNA binding residues [nucleotide binding] 743720012586 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 743720012587 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 743720012588 P-loop, Walker A motif; other site 743720012589 Base recognition motif; other site 743720012590 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 743720012591 Protein of unknown function (DUF466); Region: DUF466; pfam04328 743720012592 carbon starvation protein A; Provisional; Region: PRK15015 743720012593 Carbon starvation protein CstA; Region: CstA; pfam02554 743720012594 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 743720012595 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 743720012596 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 743720012597 Histidine kinase; Region: HisKA_3; pfam07730 743720012598 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720012599 ATP binding site [chemical binding]; other site 743720012600 Mg2+ binding site [ion binding]; other site 743720012601 G-X-G motif; other site 743720012602 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 743720012603 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720012604 active site 743720012605 phosphorylation site [posttranslational modification] 743720012606 intermolecular recognition site; other site 743720012607 dimerization interface [polypeptide binding]; other site 743720012608 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 743720012609 dimerization interface [polypeptide binding]; other site 743720012610 DNA binding residues [nucleotide binding] 743720012611 PilZ domain; Region: PilZ; pfam07238 743720012612 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 743720012613 DNA repair protein RadA; Provisional; Region: PRK11823 743720012614 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 743720012615 Walker A motif/ATP binding site; other site 743720012616 ATP binding site [chemical binding]; other site 743720012617 Walker B motif; other site 743720012618 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 743720012619 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 743720012620 Predicted acetyltransferase [General function prediction only]; Region: COG5628 743720012621 Protein of unknown function (DUF465); Region: DUF465; cl01070 743720012622 Protein of unknown function (DUF465); Region: DUF465; pfam04325 743720012623 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 743720012624 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 743720012625 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 743720012626 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 743720012627 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 743720012628 Transporter associated domain; Region: CorC_HlyC; smart01091 743720012629 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 743720012630 ferredoxin-NADP reductase; Provisional; Region: PRK10926 743720012631 FAD binding pocket [chemical binding]; other site 743720012632 FAD binding motif [chemical binding]; other site 743720012633 phosphate binding motif [ion binding]; other site 743720012634 beta-alpha-beta structure motif; other site 743720012635 NAD binding pocket [chemical binding]; other site 743720012636 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 743720012637 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 743720012638 dimer interface [polypeptide binding]; other site 743720012639 NADP binding site [chemical binding]; other site 743720012640 catalytic residues [active] 743720012641 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 743720012642 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 743720012643 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720012644 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 743720012645 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 743720012646 dimerization interface [polypeptide binding]; other site 743720012647 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 743720012648 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 743720012649 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 743720012650 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 743720012651 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720012652 S-adenosylmethionine binding site [chemical binding]; other site 743720012653 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 743720012654 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 743720012655 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720012656 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 743720012657 substrate binding pocket [chemical binding]; other site 743720012658 membrane-bound complex binding site; other site 743720012659 hinge residues; other site 743720012660 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 743720012661 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 743720012662 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 743720012663 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 743720012664 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 743720012665 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 743720012666 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 743720012667 DctM-like transporters; Region: DctM; pfam06808 743720012668 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 743720012669 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 743720012670 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 743720012671 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 743720012672 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 743720012673 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 743720012674 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 743720012675 homodimer interface [polypeptide binding]; other site 743720012676 NAD binding pocket [chemical binding]; other site 743720012677 ATP binding pocket [chemical binding]; other site 743720012678 Mg binding site [ion binding]; other site 743720012679 active-site loop [active] 743720012680 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 743720012681 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 743720012682 active site 743720012683 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 743720012684 Isochorismatase family; Region: Isochorismatase; pfam00857 743720012685 catalytic triad [active] 743720012686 metal binding site [ion binding]; metal-binding site 743720012687 conserved cis-peptide bond; other site 743720012688 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 743720012689 active site 743720012690 (T/H)XGH motif; other site 743720012691 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 743720012692 nudix motif; other site 743720012693 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 743720012694 Uncharacterized conserved protein [Function unknown]; Region: COG2128 743720012695 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 743720012696 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 743720012697 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 743720012698 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720012699 Coenzyme A binding pocket [chemical binding]; other site 743720012700 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 743720012701 arginine decarboxylase; Provisional; Region: PRK05354 743720012702 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 743720012703 dimer interface [polypeptide binding]; other site 743720012704 active site 743720012705 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 743720012706 catalytic residues [active] 743720012707 substrate binding site [chemical binding]; other site 743720012708 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 743720012709 translation initiation factor Sui1; Validated; Region: PRK06824 743720012710 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 743720012711 putative rRNA binding site [nucleotide binding]; other site 743720012712 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 743720012713 nudix motif; other site 743720012714 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; pfam10095 743720012715 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 743720012716 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 743720012717 active site 743720012718 phosphorylation site [posttranslational modification] 743720012719 intermolecular recognition site; other site 743720012720 dimerization interface [polypeptide binding]; other site 743720012721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720012722 active site 743720012723 phosphorylation site [posttranslational modification] 743720012724 intermolecular recognition site; other site 743720012725 dimerization interface [polypeptide binding]; other site 743720012726 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720012727 metal binding site [ion binding]; metal-binding site 743720012728 active site 743720012729 I-site; other site 743720012730 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720012731 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720012732 dimer interface [polypeptide binding]; other site 743720012733 putative CheW interface [polypeptide binding]; other site 743720012734 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 743720012735 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 743720012736 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 743720012737 DsbD alpha interface [polypeptide binding]; other site 743720012738 catalytic residues [active] 743720012739 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 743720012740 Dehydroquinase class II; Region: DHquinase_II; pfam01220 743720012741 active site 743720012742 trimer interface [polypeptide binding]; other site 743720012743 dimer interface [polypeptide binding]; other site 743720012744 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 743720012745 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 743720012746 carboxyltransferase (CT) interaction site; other site 743720012747 biotinylation site [posttranslational modification]; other site 743720012748 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 743720012749 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 743720012750 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 743720012751 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 743720012752 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 743720012753 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 743720012754 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720012755 S-adenosylmethionine binding site [chemical binding]; other site 743720012756 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 743720012757 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 743720012758 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 743720012759 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 743720012760 FMN binding site [chemical binding]; other site 743720012761 active site 743720012762 catalytic residues [active] 743720012763 substrate binding site [chemical binding]; other site 743720012764 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 743720012765 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 743720012766 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 743720012767 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 743720012768 purine monophosphate binding site [chemical binding]; other site 743720012769 dimer interface [polypeptide binding]; other site 743720012770 putative catalytic residues [active] 743720012771 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 743720012772 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 743720012773 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 743720012774 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 743720012775 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 743720012776 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 743720012777 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 743720012778 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 743720012779 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720012780 dimer interface [polypeptide binding]; other site 743720012781 phosphorylation site [posttranslational modification] 743720012782 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720012783 ATP binding site [chemical binding]; other site 743720012784 Mg2+ binding site [ion binding]; other site 743720012785 G-X-G motif; other site 743720012786 Response regulator receiver domain; Region: Response_reg; pfam00072 743720012787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720012788 active site 743720012789 phosphorylation site [posttranslational modification] 743720012790 intermolecular recognition site; other site 743720012791 dimerization interface [polypeptide binding]; other site 743720012792 Response regulator receiver domain; Region: Response_reg; pfam00072 743720012793 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720012794 active site 743720012795 phosphorylation site [posttranslational modification] 743720012796 intermolecular recognition site; other site 743720012797 dimerization interface [polypeptide binding]; other site 743720012798 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720012799 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720012800 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 743720012801 dimerization interface [polypeptide binding]; other site 743720012802 TLC ATP/ADP transporter; Region: TLC; cl03940 743720012803 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 743720012804 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 743720012805 ATP binding site [chemical binding]; other site 743720012806 putative Mg++ binding site [ion binding]; other site 743720012807 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743720012808 nucleotide binding region [chemical binding]; other site 743720012809 ATP-binding site [chemical binding]; other site 743720012810 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 743720012811 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 743720012812 active site 743720012813 substrate-binding site [chemical binding]; other site 743720012814 metal-binding site [ion binding] 743720012815 ATP binding site [chemical binding]; other site 743720012816 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 743720012817 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 743720012818 dimerization interface [polypeptide binding]; other site 743720012819 domain crossover interface; other site 743720012820 redox-dependent activation switch; other site 743720012821 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 743720012822 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 743720012823 RNA binding surface [nucleotide binding]; other site 743720012824 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743720012825 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 743720012826 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 743720012827 RimK-like ATP-grasp domain; Region: RimK; pfam08443 743720012828 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 743720012829 dimer interface [polypeptide binding]; other site 743720012830 catalytic triad [active] 743720012831 MASE1; Region: MASE1; cl17823 743720012832 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720012833 PAS domain; Region: PAS_9; pfam13426 743720012834 putative active site [active] 743720012835 heme pocket [chemical binding]; other site 743720012836 PAS fold; Region: PAS_3; pfam08447 743720012837 PAS domain; Region: PAS_9; pfam13426 743720012838 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720012839 putative active site [active] 743720012840 heme pocket [chemical binding]; other site 743720012841 PAS domain S-box; Region: sensory_box; TIGR00229 743720012842 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720012843 putative active site [active] 743720012844 heme pocket [chemical binding]; other site 743720012845 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743720012846 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720012847 metal binding site [ion binding]; metal-binding site 743720012848 active site 743720012849 I-site; other site 743720012850 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743720012851 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 743720012852 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 743720012853 dimerization interface [polypeptide binding]; other site 743720012854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720012855 ATP binding site [chemical binding]; other site 743720012856 Mg2+ binding site [ion binding]; other site 743720012857 G-X-G motif; other site 743720012858 osmolarity response regulator; Provisional; Region: ompR; PRK09468 743720012859 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720012860 active site 743720012861 phosphorylation site [posttranslational modification] 743720012862 intermolecular recognition site; other site 743720012863 dimerization interface [polypeptide binding]; other site 743720012864 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743720012865 DNA binding site [nucleotide binding] 743720012866 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 743720012867 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 743720012868 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 743720012869 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 743720012870 RNA binding site [nucleotide binding]; other site 743720012871 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 743720012872 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 743720012873 CoenzymeA binding site [chemical binding]; other site 743720012874 subunit interaction site [polypeptide binding]; other site 743720012875 PHB binding site; other site 743720012876 glutamate--cysteine ligase; Provisional; Region: PRK02107 743720012877 Ribosome modulation factor; Region: RMF; cl01207 743720012878 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 743720012879 MarR family; Region: MarR_2; pfam12802 743720012880 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 743720012881 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 743720012882 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 743720012883 active site 743720012884 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 743720012885 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 743720012886 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 743720012887 dimer interface [polypeptide binding]; other site 743720012888 active site 743720012889 feruloyl-CoA synthase; Reviewed; Region: PRK08180 743720012890 Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921 743720012891 acyl-activating enzyme (AAE) consensus motif; other site 743720012892 putative AMP binding site [chemical binding]; other site 743720012893 putative active site [active] 743720012894 putative CoA binding site [chemical binding]; other site 743720012895 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 743720012896 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 743720012897 NAD(P) binding site [chemical binding]; other site 743720012898 catalytic residues [active] 743720012899 p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120 743720012900 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 743720012901 substrate binding site [chemical binding]; other site 743720012902 oxyanion hole (OAH) forming residues; other site 743720012903 trimer interface [polypeptide binding]; other site 743720012904 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 743720012905 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 743720012906 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720012907 putative substrate translocation pore; other site 743720012908 outer membrane porin, OprD family; Region: OprD; pfam03573 743720012909 benzoate transport; Region: 2A0115; TIGR00895 743720012910 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720012911 putative substrate translocation pore; other site 743720012912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720012913 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 743720012914 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 743720012915 iron-sulfur cluster [ion binding]; other site 743720012916 [2Fe-2S] cluster binding site [ion binding]; other site 743720012917 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 743720012918 alpha subunit interface [polypeptide binding]; other site 743720012919 active site 743720012920 substrate binding site [chemical binding]; other site 743720012921 Fe binding site [ion binding]; other site 743720012922 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 743720012923 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 743720012924 FMN-binding pocket [chemical binding]; other site 743720012925 flavin binding motif; other site 743720012926 phosphate binding motif [ion binding]; other site 743720012927 beta-alpha-beta structure motif; other site 743720012928 NAD binding pocket [chemical binding]; other site 743720012929 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 743720012930 catalytic loop [active] 743720012931 iron binding site [ion binding]; other site 743720012932 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 743720012933 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720012934 Coenzyme A binding pocket [chemical binding]; other site 743720012935 Transcriptional regulators [Transcription]; Region: FadR; COG2186 743720012936 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720012937 DNA-binding site [nucleotide binding]; DNA binding site 743720012938 FCD domain; Region: FCD; pfam07729 743720012939 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 743720012940 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720012941 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 743720012942 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 743720012943 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 743720012944 Predicted metal-binding protein [General function prediction only]; Region: COG3019 743720012945 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 743720012946 Predicted metalloprotease [General function prediction only]; Region: COG2321 743720012947 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 743720012948 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 743720012949 NAD binding site [chemical binding]; other site 743720012950 substrate binding site [chemical binding]; other site 743720012951 homodimer interface [polypeptide binding]; other site 743720012952 active site 743720012953 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 743720012954 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 743720012955 substrate binding site; other site 743720012956 tetramer interface; other site 743720012957 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 743720012958 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 743720012959 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 743720012960 NADP binding site [chemical binding]; other site 743720012961 active site 743720012962 putative substrate binding site [chemical binding]; other site 743720012963 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 743720012964 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720012965 dimer interface [polypeptide binding]; other site 743720012966 phosphorylation site [posttranslational modification] 743720012967 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720012968 ATP binding site [chemical binding]; other site 743720012969 Mg2+ binding site [ion binding]; other site 743720012970 G-X-G motif; other site 743720012971 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 743720012972 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720012973 active site 743720012974 phosphorylation site [posttranslational modification] 743720012975 intermolecular recognition site; other site 743720012976 dimerization interface [polypeptide binding]; other site 743720012977 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720012978 Walker A motif; other site 743720012979 ATP binding site [chemical binding]; other site 743720012980 Walker B motif; other site 743720012981 arginine finger; other site 743720012982 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 743720012983 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 743720012984 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 743720012985 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 743720012986 DctM-like transporters; Region: DctM; pfam06808 743720012987 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 743720012988 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 743720012989 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK08439 743720012990 active site 743720012991 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 743720012992 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 743720012993 active site 743720012994 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 743720012995 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 743720012996 dimer interface [polypeptide binding]; other site 743720012997 ADP-ribose binding site [chemical binding]; other site 743720012998 active site 743720012999 nudix motif; other site 743720013000 metal binding site [ion binding]; metal-binding site 743720013001 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 743720013002 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743720013003 motif II; other site 743720013004 allophanate hydrolase; Provisional; Region: PRK08186 743720013005 Amidase; Region: Amidase; cl11426 743720013006 urea carboxylase; Region: urea_carbox; TIGR02712 743720013007 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 743720013008 ATP-grasp domain; Region: ATP-grasp_4; cl17255 743720013009 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 743720013010 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 743720013011 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 743720013012 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 743720013013 carboxyltransferase (CT) interaction site; other site 743720013014 biotinylation site [posttranslational modification]; other site 743720013015 Transcriptional regulators [Transcription]; Region: GntR; COG1802 743720013016 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720013017 DNA-binding site [nucleotide binding]; DNA binding site 743720013018 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 743720013019 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 743720013020 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 743720013021 putative ligand binding site [chemical binding]; other site 743720013022 HEAT repeats; Region: HEAT_2; pfam13646 743720013023 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 743720013024 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 743720013025 TM-ABC transporter signature motif; other site 743720013026 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 743720013027 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 743720013028 TM-ABC transporter signature motif; other site 743720013029 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 743720013030 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 743720013031 Walker A/P-loop; other site 743720013032 ATP binding site [chemical binding]; other site 743720013033 Q-loop/lid; other site 743720013034 ABC transporter signature motif; other site 743720013035 Walker B; other site 743720013036 D-loop; other site 743720013037 H-loop/switch region; other site 743720013038 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 743720013039 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 743720013040 Walker A/P-loop; other site 743720013041 ATP binding site [chemical binding]; other site 743720013042 Q-loop/lid; other site 743720013043 ABC transporter signature motif; other site 743720013044 Walker B; other site 743720013045 D-loop; other site 743720013046 H-loop/switch region; other site 743720013047 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 743720013048 malonic semialdehyde reductase; Provisional; Region: PRK10538 743720013049 putative NAD(P) binding site [chemical binding]; other site 743720013050 homotetramer interface [polypeptide binding]; other site 743720013051 homodimer interface [polypeptide binding]; other site 743720013052 active site 743720013053 Cache domain; Region: Cache_1; pfam02743 743720013054 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 743720013055 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720013056 dimer interface [polypeptide binding]; other site 743720013057 putative CheW interface [polypeptide binding]; other site 743720013058 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 743720013059 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720013060 Coenzyme A binding pocket [chemical binding]; other site 743720013061 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 743720013062 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720013063 Coenzyme A binding pocket [chemical binding]; other site 743720013064 hypothetical protein; Provisional; Region: PRK11019 743720013065 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 743720013066 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 743720013067 tetramer interface [polypeptide binding]; other site 743720013068 active site 743720013069 Mg2+/Mn2+ binding site [ion binding]; other site 743720013070 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 743720013071 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720013072 substrate binding pocket [chemical binding]; other site 743720013073 membrane-bound complex binding site; other site 743720013074 hinge residues; other site 743720013075 Predicted membrane protein [Function unknown]; Region: COG1238 743720013076 Predicted integral membrane protein [Function unknown]; Region: COG0392 743720013077 putative chaperone; Provisional; Region: PRK11678 743720013078 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 743720013079 nucleotide binding site [chemical binding]; other site 743720013080 putative NEF/HSP70 interaction site [polypeptide binding]; other site 743720013081 SBD interface [polypeptide binding]; other site 743720013082 hypothetical protein; Provisional; Region: PRK01254 743720013083 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 743720013084 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 743720013085 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 743720013086 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 743720013087 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743720013088 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720013089 metal binding site [ion binding]; metal-binding site 743720013090 active site 743720013091 I-site; other site 743720013092 replicative DNA helicase; Provisional; Region: PRK05748 743720013093 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 743720013094 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 743720013095 Walker A motif; other site 743720013096 ATP binding site [chemical binding]; other site 743720013097 Walker B motif; other site 743720013098 DNA binding loops [nucleotide binding] 743720013099 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 743720013100 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 743720013101 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 743720013102 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 743720013103 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 743720013104 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 743720013105 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 743720013106 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 743720013107 ribonuclease R; Region: RNase_R; TIGR02063 743720013108 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 743720013109 RNB domain; Region: RNB; pfam00773 743720013110 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 743720013111 RNA binding site [nucleotide binding]; other site 743720013112 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 743720013113 dimer interface [polypeptide binding]; other site 743720013114 putative CheW interface [polypeptide binding]; other site 743720013115 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 743720013116 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 743720013117 GDP-binding site [chemical binding]; other site 743720013118 ACT binding site; other site 743720013119 IMP binding site; other site 743720013120 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 743720013121 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 743720013122 dimer interface [polypeptide binding]; other site 743720013123 motif 1; other site 743720013124 active site 743720013125 motif 2; other site 743720013126 motif 3; other site 743720013127 FtsH protease regulator HflC; Provisional; Region: PRK11029 743720013128 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 743720013129 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 743720013130 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 743720013131 HflK protein; Region: hflK; TIGR01933 743720013132 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 743720013133 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 743720013134 HflX GTPase family; Region: HflX; cd01878 743720013135 G1 box; other site 743720013136 GTP/Mg2+ binding site [chemical binding]; other site 743720013137 Switch I region; other site 743720013138 G2 box; other site 743720013139 G3 box; other site 743720013140 Switch II region; other site 743720013141 G4 box; other site 743720013142 G5 box; other site 743720013143 bacterial Hfq-like; Region: Hfq; cd01716 743720013144 hexamer interface [polypeptide binding]; other site 743720013145 Sm1 motif; other site 743720013146 RNA binding site [nucleotide binding]; other site 743720013147 Sm2 motif; other site 743720013148 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 743720013149 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 743720013150 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 743720013151 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720013152 ATP binding site [chemical binding]; other site 743720013153 Mg2+ binding site [ion binding]; other site 743720013154 G-X-G motif; other site 743720013155 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 743720013156 ATP binding site [chemical binding]; other site 743720013157 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 743720013158 AMIN domain; Region: AMIN; pfam11741 743720013159 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 743720013160 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 743720013161 active site 743720013162 metal binding site [ion binding]; metal-binding site 743720013163 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 743720013164 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 743720013165 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 743720013166 putative carbohydrate kinase; Provisional; Region: PRK10565 743720013167 Uncharacterized conserved protein [Function unknown]; Region: COG0062 743720013168 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 743720013169 putative substrate binding site [chemical binding]; other site 743720013170 putative ATP binding site [chemical binding]; other site 743720013171 epoxyqueuosine reductase; Region: TIGR00276 743720013172 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 743720013173 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 743720013174 catalytic site [active] 743720013175 putative active site [active] 743720013176 putative substrate binding site [chemical binding]; other site 743720013177 dimer interface [polypeptide binding]; other site 743720013178 Methyltransferase domain; Region: Methyltransf_18; pfam12847 743720013179 S-adenosylmethionine binding site [chemical binding]; other site 743720013180 GTPase RsgA; Reviewed; Region: PRK12288 743720013181 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 743720013182 RNA binding site [nucleotide binding]; other site 743720013183 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 743720013184 GTPase/Zn-binding domain interface [polypeptide binding]; other site 743720013185 GTP/Mg2+ binding site [chemical binding]; other site 743720013186 G4 box; other site 743720013187 G5 box; other site 743720013188 G1 box; other site 743720013189 Switch I region; other site 743720013190 G2 box; other site 743720013191 G3 box; other site 743720013192 Switch II region; other site 743720013193 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 743720013194 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 743720013195 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 743720013196 ligand binding site [chemical binding]; other site 743720013197 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 743720013198 flagellar motor protein MotA; Validated; Region: PRK09110 743720013199 HDOD domain; Region: HDOD; pfam08668 743720013200 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 743720013201 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 743720013202 active site residue [active] 743720013203 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 743720013204 active site residue [active] 743720013205 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 743720013206 Response regulator receiver domain; Region: Response_reg; pfam00072 743720013207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720013208 active site 743720013209 phosphorylation site [posttranslational modification] 743720013210 intermolecular recognition site; other site 743720013211 PAS domain S-box; Region: sensory_box; TIGR00229 743720013212 PAS domain; Region: PAS_8; pfam13188 743720013213 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720013214 putative active site [active] 743720013215 heme pocket [chemical binding]; other site 743720013216 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720013217 metal binding site [ion binding]; metal-binding site 743720013218 active site 743720013219 I-site; other site 743720013220 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743720013221 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 743720013222 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 743720013223 phosphoserine phosphatase SerB; Region: serB; TIGR00338 743720013224 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743720013225 motif II; other site 743720013226 Uncharacterized membrane protein affecting hemolysin expression [General function prediction only]; Region: AhpA; COG3726 743720013227 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 743720013228 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 743720013229 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 743720013230 Walker A/P-loop; other site 743720013231 ATP binding site [chemical binding]; other site 743720013232 Q-loop/lid; other site 743720013233 ABC transporter signature motif; other site 743720013234 Walker B; other site 743720013235 D-loop; other site 743720013236 H-loop/switch region; other site 743720013237 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 743720013238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720013239 dimer interface [polypeptide binding]; other site 743720013240 conserved gate region; other site 743720013241 putative PBP binding loops; other site 743720013242 ABC-ATPase subunit interface; other site 743720013243 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 743720013244 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 743720013245 active site 743720013246 dimer interface [polypeptide binding]; other site 743720013247 non-prolyl cis peptide bond; other site 743720013248 insertion regions; other site 743720013249 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 743720013250 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720013251 substrate binding pocket [chemical binding]; other site 743720013252 membrane-bound complex binding site; other site 743720013253 hinge residues; other site 743720013254 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 743720013255 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 743720013256 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 743720013257 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 743720013258 dimer interface [polypeptide binding]; other site 743720013259 decamer (pentamer of dimers) interface [polypeptide binding]; other site 743720013260 catalytic triad [active] 743720013261 maltose O-acetyltransferase; Provisional; Region: PRK10092 743720013262 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 743720013263 active site 743720013264 substrate binding site [chemical binding]; other site 743720013265 trimer interface [polypeptide binding]; other site 743720013266 CoA binding site [chemical binding]; other site 743720013267 DNA polymerase II; Reviewed; Region: PRK05762 743720013268 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 743720013269 active site 743720013270 catalytic site [active] 743720013271 substrate binding site [chemical binding]; other site 743720013272 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 743720013273 active site 743720013274 metal-binding site 743720013275 Methyltransferase domain; Region: Methyltransf_23; pfam13489 743720013276 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720013277 S-adenosylmethionine binding site [chemical binding]; other site 743720013278 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 743720013279 potassium uptake protein; Region: kup; TIGR00794 743720013280 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 743720013281 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 743720013282 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720013283 dimer interface [polypeptide binding]; other site 743720013284 phosphorylation site [posttranslational modification] 743720013285 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720013286 ATP binding site [chemical binding]; other site 743720013287 Mg2+ binding site [ion binding]; other site 743720013288 G-X-G motif; other site 743720013289 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 743720013290 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720013291 active site 743720013292 phosphorylation site [posttranslational modification] 743720013293 intermolecular recognition site; other site 743720013294 dimerization interface [polypeptide binding]; other site 743720013295 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 743720013296 DNA binding site [nucleotide binding] 743720013297 transcriptional regulator BetI; Validated; Region: PRK00767 743720013298 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 743720013299 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 743720013300 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 743720013301 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 743720013302 tetrameric interface [polypeptide binding]; other site 743720013303 NAD binding site [chemical binding]; other site 743720013304 catalytic residues [active] 743720013305 choline dehydrogenase; Validated; Region: PRK02106 743720013306 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 743720013307 putative transporter; Provisional; Region: PRK10504 743720013308 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720013309 putative substrate translocation pore; other site 743720013310 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 743720013311 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 743720013312 ATP binding site [chemical binding]; other site 743720013313 Mg++ binding site [ion binding]; other site 743720013314 motif III; other site 743720013315 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 743720013316 nucleotide binding region [chemical binding]; other site 743720013317 ATP-binding site [chemical binding]; other site 743720013318 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 743720013319 putative RNA binding site [nucleotide binding]; other site 743720013320 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 743720013321 Response regulator receiver domain; Region: Response_reg; pfam00072 743720013322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720013323 active site 743720013324 phosphorylation site [posttranslational modification] 743720013325 intermolecular recognition site; other site 743720013326 dimerization interface [polypeptide binding]; other site 743720013327 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 743720013328 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720013329 metal binding site [ion binding]; metal-binding site 743720013330 active site 743720013331 I-site; other site 743720013332 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 743720013333 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720013334 substrate binding pocket [chemical binding]; other site 743720013335 membrane-bound complex binding site; other site 743720013336 hinge residues; other site 743720013337 HI0933-like protein; Region: HI0933_like; pfam03486 743720013338 hydroxyglutarate oxidase; Provisional; Region: PRK11728 743720013339 serine/threonine transporter SstT; Provisional; Region: PRK13628 743720013340 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 743720013341 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 743720013342 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 743720013343 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 743720013344 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720013345 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720013346 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 743720013347 putative dimerization interface [polypeptide binding]; other site 743720013348 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 743720013349 Protein of unknown function (DUF330); Region: DUF330; pfam03886 743720013350 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 743720013351 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 743720013352 CAP-like domain; other site 743720013353 active site 743720013354 primary dimer interface [polypeptide binding]; other site 743720013355 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 743720013356 catalytic motif [active] 743720013357 Catalytic residue [active] 743720013358 SdiA-regulated; Region: SdiA-regulated; cd09971 743720013359 putative active site [active] 743720013360 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 743720013361 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720013362 ATP binding site [chemical binding]; other site 743720013363 Mg2+ binding site [ion binding]; other site 743720013364 G-X-G motif; other site 743720013365 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 743720013366 anchoring element; other site 743720013367 dimer interface [polypeptide binding]; other site 743720013368 ATP binding site [chemical binding]; other site 743720013369 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 743720013370 active site 743720013371 metal binding site [ion binding]; metal-binding site 743720013372 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 743720013373 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 743720013374 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 743720013375 active site 743720013376 metal binding site [ion binding]; metal-binding site 743720013377 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 743720013378 hexamer interface [polypeptide binding]; other site 743720013379 Protein of unknown function (DUF1249); Region: DUF1249; cl01223 743720013380 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 743720013381 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 743720013382 dimer interface [polypeptide binding]; other site 743720013383 ADP-ribose binding site [chemical binding]; other site 743720013384 active site 743720013385 nudix motif; other site 743720013386 metal binding site [ion binding]; metal-binding site 743720013387 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 743720013388 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 743720013389 ThiC-associated domain; Region: ThiC-associated; pfam13667 743720013390 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 743720013391 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 743720013392 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 743720013393 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 743720013394 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 743720013395 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720013396 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720013397 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 743720013398 dimerization interface [polypeptide binding]; other site 743720013399 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 743720013400 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 743720013401 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 743720013402 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 743720013403 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 743720013404 active site 743720013405 catalytic tetrad [active] 743720013406 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 743720013407 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 743720013408 putative ribose interaction site [chemical binding]; other site 743720013409 putative ADP binding site [chemical binding]; other site 743720013410 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 743720013411 active site 743720013412 nucleotide binding site [chemical binding]; other site 743720013413 HIGH motif; other site 743720013414 KMSKS motif; other site 743720013415 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 743720013416 Mig-14; Region: Mig-14; pfam07395 743720013417 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 743720013418 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 743720013419 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 743720013420 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 743720013421 Walker A/P-loop; other site 743720013422 ATP binding site [chemical binding]; other site 743720013423 Q-loop/lid; other site 743720013424 ABC transporter signature motif; other site 743720013425 Walker B; other site 743720013426 D-loop; other site 743720013427 H-loop/switch region; other site 743720013428 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 743720013429 active site 743720013430 substrate binding site [chemical binding]; other site 743720013431 ATP binding site [chemical binding]; other site 743720013432 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 743720013433 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 743720013434 inhibitor-cofactor binding pocket; inhibition site 743720013435 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720013436 catalytic residue [active] 743720013437 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 743720013438 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 743720013439 trimer interface [polypeptide binding]; other site 743720013440 active site 743720013441 substrate binding site [chemical binding]; other site 743720013442 CoA binding site [chemical binding]; other site 743720013443 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 743720013444 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 743720013445 active site 743720013446 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 743720013447 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 743720013448 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 743720013449 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 743720013450 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 743720013451 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 743720013452 active site 743720013453 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 743720013454 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 743720013455 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 743720013456 active site 743720013457 ATP binding site [chemical binding]; other site 743720013458 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 743720013459 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 743720013460 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 743720013461 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 743720013462 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 743720013463 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 743720013464 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 743720013465 putative active site [active] 743720013466 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 743720013467 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 743720013468 putative active site [active] 743720013469 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 743720013470 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 743720013471 metal binding triad; other site 743720013472 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 743720013473 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 743720013474 metal binding triad; other site 743720013475 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 743720013476 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 743720013477 dimer interface [polypeptide binding]; other site 743720013478 TPP-binding site [chemical binding]; other site 743720013479 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 743720013480 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 743720013481 E3 interaction surface; other site 743720013482 lipoyl attachment site [posttranslational modification]; other site 743720013483 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 743720013484 E3 interaction surface; other site 743720013485 lipoyl attachment site [posttranslational modification]; other site 743720013486 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 743720013487 E3 interaction surface; other site 743720013488 lipoyl attachment site [posttranslational modification]; other site 743720013489 e3 binding domain; Region: E3_binding; pfam02817 743720013490 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 743720013491 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 743720013492 GAF domain; Region: GAF; pfam01590 743720013493 RNase II stability modulator; Provisional; Region: PRK10060 743720013494 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720013495 putative active site [active] 743720013496 heme pocket [chemical binding]; other site 743720013497 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 743720013498 metal binding site [ion binding]; metal-binding site 743720013499 active site 743720013500 I-site; other site 743720013501 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 743720013502 methionine sulfoxide reductase A; Provisional; Region: PRK00058 743720013503 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 743720013504 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 743720013505 Zn2+ binding site [ion binding]; other site 743720013506 Mg2+ binding site [ion binding]; other site 743720013507 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 743720013508 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 743720013509 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 743720013510 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 743720013511 active site 743720013512 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 743720013513 polyphosphate kinase; Provisional; Region: PRK05443 743720013514 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 743720013515 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 743720013516 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 743720013517 putative active site [active] 743720013518 catalytic site [active] 743720013519 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 743720013520 putative domain interface [polypeptide binding]; other site 743720013521 putative active site [active] 743720013522 catalytic site [active] 743720013523 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 743720013524 dimer interface [polypeptide binding]; other site 743720013525 active site 743720013526 aspartate-rich active site metal binding site; other site 743720013527 allosteric magnesium binding site [ion binding]; other site 743720013528 Schiff base residues; other site 743720013529 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 743720013530 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 743720013531 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 743720013532 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 743720013533 conserved cys residue [active] 743720013534 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 743720013535 LysE type translocator; Region: LysE; cl00565 743720013536 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 743720013537 Mechanosensitive ion channel; Region: MS_channel; pfam00924 743720013538 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 743720013539 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 743720013540 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 743720013541 ABC transporter; Region: ABC_tran_2; pfam12848 743720013542 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 743720013543 Protein of unknown function (DUF2390); Region: DUF2390; pfam09523 743720013544 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; pfam09650 743720013545 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 743720013546 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 743720013547 S-adenosylmethionine binding site [chemical binding]; other site 743720013548 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 743720013549 SCP-2 sterol transfer family; Region: SCP2; pfam02036 743720013550 ABC1 family; Region: ABC1; cl17513 743720013551 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 743720013552 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 743720013553 metal binding site [ion binding]; metal-binding site 743720013554 twin arginine translocase protein A; Provisional; Region: tatA; PRK00442 743720013555 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 743720013556 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 743720013557 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 743720013558 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 743720013559 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 743720013560 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 743720013561 putative acyl-acceptor binding pocket; other site 743720013562 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 743720013563 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 743720013564 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 743720013565 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 743720013566 NAD binding site [chemical binding]; other site 743720013567 catalytic Zn binding site [ion binding]; other site 743720013568 structural Zn binding site [ion binding]; other site 743720013569 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 743720013570 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 743720013571 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 743720013572 putative active site [active] 743720013573 putative substrate binding site [chemical binding]; other site 743720013574 putative cosubstrate binding site; other site 743720013575 catalytic site [active] 743720013576 Sarcosine oxidase, gamma subunit family; Region: SoxG; pfam04268 743720013577 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 743720013578 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 743720013579 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 743720013580 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 743720013581 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 743720013582 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 743720013583 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 743720013584 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 743720013585 dimer interface [polypeptide binding]; other site 743720013586 active site 743720013587 glycine-pyridoxal phosphate binding site [chemical binding]; other site 743720013588 folate binding site [chemical binding]; other site 743720013589 TraX protein; Region: TraX; cl05434 743720013590 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 743720013591 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 743720013592 tetramer interface [polypeptide binding]; other site 743720013593 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720013594 catalytic residue [active] 743720013595 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 743720013596 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 743720013597 FAD binding pocket [chemical binding]; other site 743720013598 FAD binding motif [chemical binding]; other site 743720013599 phosphate binding motif [ion binding]; other site 743720013600 beta-alpha-beta structure motif; other site 743720013601 NAD binding pocket [chemical binding]; other site 743720013602 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 743720013603 catalytic loop [active] 743720013604 iron binding site [ion binding]; other site 743720013605 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 743720013606 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 743720013607 [2Fe-2S] cluster binding site [ion binding]; other site 743720013608 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 743720013609 putative alpha subunit interface [polypeptide binding]; other site 743720013610 putative active site [active] 743720013611 putative substrate binding site [chemical binding]; other site 743720013612 Fe binding site [ion binding]; other site 743720013613 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 743720013614 active site 743720013615 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 743720013616 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 743720013617 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 743720013618 Uncharacterized conserved protein [Function unknown]; Region: COG3246 743720013619 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 743720013620 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 743720013621 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 743720013622 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 743720013623 conserved cys residue [active] 743720013624 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 743720013625 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 743720013626 active site 743720013627 dimer interface [polypeptide binding]; other site 743720013628 V4R domain; Region: V4R; cl15268 743720013629 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 743720013630 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 743720013631 putative active site [active] 743720013632 putative FMN binding site [chemical binding]; other site 743720013633 putative substrate binding site [chemical binding]; other site 743720013634 putative catalytic residue [active] 743720013635 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 743720013636 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 743720013637 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 743720013638 Cysteine-rich domain; Region: CCG; pfam02754 743720013639 Cysteine-rich domain; Region: CCG; pfam02754 743720013640 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 743720013641 Ligand binding site [chemical binding]; other site 743720013642 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 743720013643 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 743720013644 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 743720013645 Ligand Binding Site [chemical binding]; other site 743720013646 Electron transfer flavoprotein domain; Region: ETF; pfam01012 743720013647 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 743720013648 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 743720013649 conserved cys residue [active] 743720013650 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720013651 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 743720013652 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 743720013653 Walker A/P-loop; other site 743720013654 ATP binding site [chemical binding]; other site 743720013655 Q-loop/lid; other site 743720013656 ABC transporter signature motif; other site 743720013657 Walker B; other site 743720013658 D-loop; other site 743720013659 H-loop/switch region; other site 743720013660 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 743720013661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720013662 dimer interface [polypeptide binding]; other site 743720013663 conserved gate region; other site 743720013664 putative PBP binding loops; other site 743720013665 ABC-ATPase subunit interface; other site 743720013666 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 743720013667 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 743720013668 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 743720013669 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 743720013670 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 743720013671 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 743720013672 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720013673 dimer interface [polypeptide binding]; other site 743720013674 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 743720013675 conserved gate region; other site 743720013676 putative PBP binding loops; other site 743720013677 ABC-ATPase subunit interface; other site 743720013678 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 743720013679 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743720013680 Walker A/P-loop; other site 743720013681 ATP binding site [chemical binding]; other site 743720013682 Q-loop/lid; other site 743720013683 ABC transporter signature motif; other site 743720013684 Walker B; other site 743720013685 D-loop; other site 743720013686 H-loop/switch region; other site 743720013687 TOBE domain; Region: TOBE; pfam03459 743720013688 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 743720013689 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720013690 Walker A motif; other site 743720013691 ATP binding site [chemical binding]; other site 743720013692 Walker B motif; other site 743720013693 arginine finger; other site 743720013694 Serine hydrolase; Region: Ser_hydrolase; pfam06821 743720013695 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 743720013696 Uncharacterized small protein [Function unknown]; Region: COG5583 743720013697 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 743720013698 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720013699 substrate binding pocket [chemical binding]; other site 743720013700 membrane-bound complex binding site; other site 743720013701 hinge residues; other site 743720013702 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 743720013703 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720013704 dimer interface [polypeptide binding]; other site 743720013705 conserved gate region; other site 743720013706 putative PBP binding loops; other site 743720013707 ABC-ATPase subunit interface; other site 743720013708 sulfate transport protein; Provisional; Region: cysT; CHL00187 743720013709 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720013710 dimer interface [polypeptide binding]; other site 743720013711 conserved gate region; other site 743720013712 putative PBP binding loops; other site 743720013713 ABC-ATPase subunit interface; other site 743720013714 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 743720013715 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 743720013716 Walker A/P-loop; other site 743720013717 ATP binding site [chemical binding]; other site 743720013718 Q-loop/lid; other site 743720013719 ABC transporter signature motif; other site 743720013720 Walker B; other site 743720013721 D-loop; other site 743720013722 H-loop/switch region; other site 743720013723 TOBE-like domain; Region: TOBE_3; pfam12857 743720013724 Predicted membrane protein [Function unknown]; Region: COG4539 743720013725 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 743720013726 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 743720013727 ligand binding site [chemical binding]; other site 743720013728 flexible hinge region; other site 743720013729 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 743720013730 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 743720013731 metal binding site [ion binding]; metal-binding site 743720013732 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 743720013733 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 743720013734 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 743720013735 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 743720013736 folate binding site [chemical binding]; other site 743720013737 NADP+ binding site [chemical binding]; other site 743720013738 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 743720013739 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 743720013740 putative active site [active] 743720013741 catalytic site [active] 743720013742 putative metal binding site [ion binding]; other site 743720013743 Protein of unknown function (DUF2868); Region: DUF2868; pfam11067 743720013744 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 743720013745 G1 box; other site 743720013746 GTP/Mg2+ binding site [chemical binding]; other site 743720013747 G2 box; other site 743720013748 Switch I region; other site 743720013749 G3 box; other site 743720013750 Switch II region; other site 743720013751 G4 box; other site 743720013752 Domain of unknown function (DUF3482); Region: DUF3482; pfam11981 743720013753 Cupin domain; Region: Cupin_2; pfam07883 743720013754 EamA-like transporter family; Region: EamA; pfam00892 743720013755 EamA-like transporter family; Region: EamA; pfam00892 743720013756 transcriptional activator TtdR; Provisional; Region: PRK09801 743720013757 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720013758 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 743720013759 putative effector binding pocket; other site 743720013760 dimerization interface [polypeptide binding]; other site 743720013761 thymidylate synthase; Reviewed; Region: thyA; PRK01827 743720013762 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 743720013763 dimerization interface [polypeptide binding]; other site 743720013764 active site 743720013765 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 743720013766 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 743720013767 hypothetical protein; Provisional; Region: PRK10039 743720013768 NRDE protein; Region: NRDE; cl01315 743720013769 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 743720013770 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 743720013771 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 743720013772 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 743720013773 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 743720013774 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 743720013775 putative active site [active] 743720013776 Ap4A binding site [chemical binding]; other site 743720013777 nudix motif; other site 743720013778 putative metal binding site [ion binding]; other site 743720013779 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 743720013780 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 743720013781 motif II; other site 743720013782 SnoaL-like domain; Region: SnoaL_3; pfam13474 743720013783 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 743720013784 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 743720013785 Histidine kinase; Region: HisKA_3; pfam07730 743720013786 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720013787 ATP binding site [chemical binding]; other site 743720013788 Mg2+ binding site [ion binding]; other site 743720013789 G-X-G motif; other site 743720013790 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 743720013791 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720013792 active site 743720013793 phosphorylation site [posttranslational modification] 743720013794 intermolecular recognition site; other site 743720013795 dimerization interface [polypeptide binding]; other site 743720013796 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 743720013797 DNA binding residues [nucleotide binding] 743720013798 dimerization interface [polypeptide binding]; other site 743720013799 CHASE3 domain; Region: CHASE3; pfam05227 743720013800 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720013801 PAS domain; Region: PAS_9; pfam13426 743720013802 putative active site [active] 743720013803 heme pocket [chemical binding]; other site 743720013804 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720013805 dimer interface [polypeptide binding]; other site 743720013806 phosphorylation site [posttranslational modification] 743720013807 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720013808 ATP binding site [chemical binding]; other site 743720013809 Mg2+ binding site [ion binding]; other site 743720013810 G-X-G motif; other site 743720013811 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 743720013812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720013813 active site 743720013814 phosphorylation site [posttranslational modification] 743720013815 intermolecular recognition site; other site 743720013816 dimerization interface [polypeptide binding]; other site 743720013817 Response regulator receiver domain; Region: Response_reg; pfam00072 743720013818 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720013819 active site 743720013820 phosphorylation site [posttranslational modification] 743720013821 intermolecular recognition site; other site 743720013822 dimerization interface [polypeptide binding]; other site 743720013823 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 743720013824 threonine dehydratase; Reviewed; Region: PRK09224 743720013825 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 743720013826 tetramer interface [polypeptide binding]; other site 743720013827 pyridoxal 5'-phosphate binding site [chemical binding]; other site 743720013828 catalytic residue [active] 743720013829 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 743720013830 putative Ile/Val binding site [chemical binding]; other site 743720013831 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 743720013832 putative Ile/Val binding site [chemical binding]; other site 743720013833 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 743720013834 tetramer (dimer of dimers) interface [polypeptide binding]; other site 743720013835 active site 743720013836 dimer interface [polypeptide binding]; other site 743720013837 SdiA-regulated; Region: SdiA-regulated; pfam06977 743720013838 SdiA-regulated; Region: SdiA-regulated; cd09971 743720013839 putative active site [active] 743720013840 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 743720013841 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 743720013842 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 743720013843 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 743720013844 FAD binding domain; Region: FAD_binding_4; pfam01565 743720013845 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 743720013846 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 743720013847 ligand binding site [chemical binding]; other site 743720013848 NAD binding site [chemical binding]; other site 743720013849 tetramer interface [polypeptide binding]; other site 743720013850 catalytic site [active] 743720013851 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 743720013852 L-serine binding site [chemical binding]; other site 743720013853 ACT domain interface; other site 743720013854 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 743720013855 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 743720013856 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 743720013857 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 743720013858 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 743720013859 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 743720013860 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 743720013861 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 743720013862 active site 743720013863 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 743720013864 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 743720013865 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 743720013866 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 743720013867 peptide binding site [polypeptide binding]; other site 743720013868 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 743720013869 hypothetical protein; Reviewed; Region: PRK00024 743720013870 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 743720013871 MPN+ (JAMM) motif; other site 743720013872 Zinc-binding site [ion binding]; other site 743720013873 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 743720013874 Flavoprotein; Region: Flavoprotein; pfam02441 743720013875 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 743720013876 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 743720013877 trimer interface [polypeptide binding]; other site 743720013878 active site 743720013879 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 743720013880 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 743720013881 active site 743720013882 substrate binding site [chemical binding]; other site 743720013883 metal binding site [ion binding]; metal-binding site 743720013884 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 743720013885 feedback inhibition sensing region; other site 743720013886 homohexameric interface [polypeptide binding]; other site 743720013887 nucleotide binding site [chemical binding]; other site 743720013888 N-acetyl-L-glutamate binding site [chemical binding]; other site 743720013889 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 743720013890 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 743720013891 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 743720013892 DctM-like transporters; Region: DctM; pfam06808 743720013893 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 743720013894 active site 743720013895 phosphate binding residues; other site 743720013896 catalytic residues [active] 743720013897 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 743720013898 G1 box; other site 743720013899 GTP/Mg2+ binding site [chemical binding]; other site 743720013900 Switch I region; other site 743720013901 G2 box; other site 743720013902 G3 box; other site 743720013903 Switch II region; other site 743720013904 G4 box; other site 743720013905 G5 box; other site 743720013906 DNA polymerase I; Provisional; Region: PRK05755 743720013907 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 743720013908 active site 743720013909 metal binding site 1 [ion binding]; metal-binding site 743720013910 putative 5' ssDNA interaction site; other site 743720013911 metal binding site 3; metal-binding site 743720013912 metal binding site 2 [ion binding]; metal-binding site 743720013913 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 743720013914 putative DNA binding site [nucleotide binding]; other site 743720013915 putative metal binding site [ion binding]; other site 743720013916 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 743720013917 active site 743720013918 catalytic site [active] 743720013919 substrate binding site [chemical binding]; other site 743720013920 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 743720013921 active site 743720013922 DNA binding site [nucleotide binding] 743720013923 catalytic site [active] 743720013924 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 743720013925 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 743720013926 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 743720013927 putative active site [active] 743720013928 putative substrate binding site [chemical binding]; other site 743720013929 ATP binding site [chemical binding]; other site 743720013930 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 743720013931 ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531 743720013932 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 743720013933 metal binding site [ion binding]; metal-binding site 743720013934 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 743720013935 metal binding site 2 [ion binding]; metal-binding site 743720013936 putative DNA binding helix; other site 743720013937 metal binding site 1 [ion binding]; metal-binding site 743720013938 dimer interface [polypeptide binding]; other site 743720013939 structural Zn2+ binding site [ion binding]; other site 743720013940 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 743720013941 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 743720013942 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 743720013943 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 743720013944 dimer interface [polypeptide binding]; other site 743720013945 putative PBP binding regions; other site 743720013946 ABC-ATPase subunit interface; other site 743720013947 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 743720013948 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 743720013949 Walker A/P-loop; other site 743720013950 ATP binding site [chemical binding]; other site 743720013951 Q-loop/lid; other site 743720013952 ABC transporter signature motif; other site 743720013953 Walker B; other site 743720013954 D-loop; other site 743720013955 H-loop/switch region; other site 743720013956 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 743720013957 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720013958 dimer interface [polypeptide binding]; other site 743720013959 conserved gate region; other site 743720013960 ABC-ATPase subunit interface; other site 743720013961 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 743720013962 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 743720013963 Uncharacterized conserved protein [Function unknown]; Region: COG3791 743720013964 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720013965 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720013966 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 743720013967 putative dimerization interface [polypeptide binding]; other site 743720013968 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 743720013969 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 743720013970 putative metal binding site [ion binding]; other site 743720013971 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 743720013972 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 743720013973 Cu(I) binding site [ion binding]; other site 743720013974 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 743720013975 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 743720013976 Sulfate transporter family; Region: Sulfate_transp; pfam00916 743720013977 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 743720013978 active site clefts [active] 743720013979 zinc binding site [ion binding]; other site 743720013980 dimer interface [polypeptide binding]; other site 743720013981 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 743720013982 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 743720013983 active site 743720013984 dimer interface [polypeptide binding]; other site 743720013985 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 743720013986 dimer interface [polypeptide binding]; other site 743720013987 active site 743720013988 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 743720013989 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 743720013990 putative substrate binding site [chemical binding]; other site 743720013991 putative ATP binding site [chemical binding]; other site 743720013992 D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809 743720013993 N- and C-terminal domain interface [polypeptide binding]; other site 743720013994 D-xylulose kinase; Region: XylB; TIGR01312 743720013995 active site 743720013996 MgATP binding site [chemical binding]; other site 743720013997 catalytic site [active] 743720013998 metal binding site [ion binding]; metal-binding site 743720013999 xylulose binding site [chemical binding]; other site 743720014000 putative homodimer interface [polypeptide binding]; other site 743720014001 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 743720014002 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 743720014003 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 743720014004 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 743720014005 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743720014006 Walker A/P-loop; other site 743720014007 ATP binding site [chemical binding]; other site 743720014008 Q-loop/lid; other site 743720014009 ABC transporter signature motif; other site 743720014010 Walker B; other site 743720014011 D-loop; other site 743720014012 H-loop/switch region; other site 743720014013 TOBE domain; Region: TOBE_2; pfam08402 743720014014 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 743720014015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720014016 dimer interface [polypeptide binding]; other site 743720014017 conserved gate region; other site 743720014018 ABC-ATPase subunit interface; other site 743720014019 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 743720014020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720014021 dimer interface [polypeptide binding]; other site 743720014022 conserved gate region; other site 743720014023 putative PBP binding loops; other site 743720014024 ABC-ATPase subunit interface; other site 743720014025 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 743720014026 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 743720014027 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 743720014028 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 743720014029 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 743720014030 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720014031 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 743720014032 active site clefts [active] 743720014033 zinc binding site [ion binding]; other site 743720014034 dimer interface [polypeptide binding]; other site 743720014035 Radical SAM superfamily; Region: Radical_SAM; pfam04055 743720014036 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 743720014037 FeS/SAM binding site; other site 743720014038 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 743720014039 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 743720014040 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 743720014041 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 743720014042 cytochrome c-550; Provisional; Region: psbV; cl17239 743720014043 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 743720014044 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 743720014045 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 743720014046 HlyD family secretion protein; Region: HlyD_3; pfam13437 743720014047 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 743720014048 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 743720014049 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 743720014050 Activator of aromatic catabolism; Region: XylR_N; pfam06505 743720014051 V4R domain; Region: V4R; pfam02830 743720014052 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720014053 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 743720014054 Walker A motif; other site 743720014055 ATP binding site [chemical binding]; other site 743720014056 Walker B motif; other site 743720014057 arginine finger; other site 743720014058 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 743720014059 NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152 743720014060 NAD(P) binding site [chemical binding]; other site 743720014061 catalytic residues [active] 743720014062 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 743720014063 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 743720014064 NAD(P) binding site [chemical binding]; other site 743720014065 3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428 743720014066 active site 743720014067 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 743720014068 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 743720014069 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 743720014070 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 743720014071 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 743720014072 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720014073 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 743720014074 Protein of unknown function; Region: DUF3658; pfam12395 743720014075 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 743720014076 FAD binding domain; Region: FAD_binding_4; pfam01565 743720014077 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 743720014078 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 743720014079 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 743720014080 Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526 743720014081 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 743720014082 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 743720014083 active site 743720014084 Zn binding site [ion binding]; other site 743720014085 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 743720014086 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 743720014087 trimer interface [polypeptide binding]; other site 743720014088 putative metal binding site [ion binding]; other site 743720014089 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 743720014090 RES domain; Region: RES; pfam08808 743720014091 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 743720014092 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720014093 Coenzyme A binding pocket [chemical binding]; other site 743720014094 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 743720014095 hydroxyglutarate oxidase; Provisional; Region: PRK11728 743720014096 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 743720014097 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 743720014098 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 743720014099 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 743720014100 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 743720014101 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 743720014102 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 743720014103 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 743720014104 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 743720014105 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 743720014106 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 743720014107 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 743720014108 YedD-like protein; Region: YedD; cl08117 743720014109 conserved hypothetical protein; Region: TIGR02270 743720014110 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 743720014111 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 743720014112 active site flap/lid [active] 743720014113 nucleophilic elbow; other site 743720014114 catalytic triad [active] 743720014115 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 743720014116 Predicted membrane protein [Function unknown]; Region: COG2261 743720014117 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 743720014118 ATP-grasp domain; Region: ATP-grasp; pfam02222 743720014119 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 743720014120 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 743720014121 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 743720014122 NAD binding site [chemical binding]; other site 743720014123 substrate binding site [chemical binding]; other site 743720014124 catalytic Zn binding site [ion binding]; other site 743720014125 tetramer interface [polypeptide binding]; other site 743720014126 structural Zn binding site [ion binding]; other site 743720014127 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 743720014128 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720014129 substrate binding pocket [chemical binding]; other site 743720014130 membrane-bound complex binding site; other site 743720014131 hinge residues; other site 743720014132 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 743720014133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720014134 dimer interface [polypeptide binding]; other site 743720014135 conserved gate region; other site 743720014136 putative PBP binding loops; other site 743720014137 ABC-ATPase subunit interface; other site 743720014138 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 743720014139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720014140 dimer interface [polypeptide binding]; other site 743720014141 conserved gate region; other site 743720014142 putative PBP binding loops; other site 743720014143 ABC-ATPase subunit interface; other site 743720014144 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 743720014145 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 743720014146 Walker A/P-loop; other site 743720014147 ATP binding site [chemical binding]; other site 743720014148 Q-loop/lid; other site 743720014149 ABC transporter signature motif; other site 743720014150 Walker B; other site 743720014151 D-loop; other site 743720014152 H-loop/switch region; other site 743720014153 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 743720014154 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 743720014155 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 743720014156 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720014157 dimer interface [polypeptide binding]; other site 743720014158 phosphorylation site [posttranslational modification] 743720014159 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720014160 Mg2+ binding site [ion binding]; other site 743720014161 G-X-G motif; other site 743720014162 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 743720014163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720014164 active site 743720014165 phosphorylation site [posttranslational modification] 743720014166 intermolecular recognition site; other site 743720014167 dimerization interface [polypeptide binding]; other site 743720014168 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720014169 Walker A motif; other site 743720014170 ATP binding site [chemical binding]; other site 743720014171 Walker B motif; other site 743720014172 arginine finger; other site 743720014173 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 743720014174 Secretin and TonB N terminus short domain; Region: STN; smart00965 743720014175 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 743720014176 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 743720014177 N-terminal plug; other site 743720014178 ligand-binding site [chemical binding]; other site 743720014179 fec operon regulator FecR; Reviewed; Region: PRK09774 743720014180 FecR protein; Region: FecR; pfam04773 743720014181 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 743720014182 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 743720014183 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 743720014184 DNA binding residues [nucleotide binding] 743720014185 cell density-dependent motility repressor; Provisional; Region: PRK10082 743720014186 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720014187 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 743720014188 dimerization interface [polypeptide binding]; other site 743720014189 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 743720014190 Aspartase; Region: Aspartase; cd01357 743720014191 active sites [active] 743720014192 tetramer interface [polypeptide binding]; other site 743720014193 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 743720014194 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 743720014195 substrate binding pocket [chemical binding]; other site 743720014196 membrane-bound complex binding site; other site 743720014197 hinge residues; other site 743720014198 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 743720014199 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 743720014200 non-specific DNA binding site [nucleotide binding]; other site 743720014201 salt bridge; other site 743720014202 sequence-specific DNA binding site [nucleotide binding]; other site 743720014203 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 743720014204 amino acid carrier protein; Region: agcS; TIGR00835 743720014205 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 743720014206 active site 743720014207 homodimer interface [polypeptide binding]; other site 743720014208 glutaminase; Provisional; Region: PRK00971 743720014209 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 743720014210 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040 743720014211 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 743720014212 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 743720014213 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 743720014214 substrate binding pocket [chemical binding]; other site 743720014215 membrane-bound complex binding site; other site 743720014216 hinge residues; other site 743720014217 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 743720014218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 743720014219 dimer interface [polypeptide binding]; other site 743720014220 conserved gate region; other site 743720014221 putative PBP binding loops; other site 743720014222 ABC-ATPase subunit interface; other site 743720014223 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 743720014224 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 743720014225 Coenzyme A binding pocket [chemical binding]; other site 743720014226 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 743720014227 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 743720014228 Predicted transporter component [General function prediction only]; Region: COG2391 743720014229 Sulphur transport; Region: Sulf_transp; pfam04143 743720014230 pyruvate carboxylase subunit B; Validated; Region: PRK09282 743720014231 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 743720014232 active site 743720014233 catalytic residues [active] 743720014234 metal binding site [ion binding]; metal-binding site 743720014235 homodimer binding site [polypeptide binding]; other site 743720014236 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 743720014237 carboxyltransferase (CT) interaction site; other site 743720014238 biotinylation site [posttranslational modification]; other site 743720014239 pyruvate carboxylase subunit A; Validated; Region: PRK07178 743720014240 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 743720014241 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 743720014242 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 743720014243 Transcriptional regulator [Transcription]; Region: LysR; COG0583 743720014244 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 743720014245 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 743720014246 putative dimerization interface [polypeptide binding]; other site 743720014247 Transcriptional regulators [Transcription]; Region: GntR; COG1802 743720014248 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 743720014249 DNA-binding site [nucleotide binding]; DNA binding site 743720014250 FCD domain; Region: FCD; pfam07729 743720014251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 743720014252 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 743720014253 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 743720014254 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 743720014255 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 743720014256 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 743720014257 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 743720014258 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 743720014259 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 743720014260 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 743720014261 PAS fold; Region: PAS_4; pfam08448 743720014262 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 743720014263 putative active site [active] 743720014264 heme pocket [chemical binding]; other site 743720014265 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 743720014266 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720014267 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 743720014268 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 743720014269 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 743720014270 inhibitor site; inhibition site 743720014271 active site 743720014272 dimer interface [polypeptide binding]; other site 743720014273 catalytic residue [active] 743720014274 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 743720014275 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 743720014276 dimer interface [polypeptide binding]; other site 743720014277 NADP binding site [chemical binding]; other site 743720014278 catalytic residues [active] 743720014279 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 743720014280 metabolite-proton symporter; Region: 2A0106; TIGR00883 743720014281 putative substrate translocation pore; other site 743720014282 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 743720014283 Leucine-rich repeats; other site 743720014284 Substrate binding site [chemical binding]; other site 743720014285 Leucine rich repeat; Region: LRR_8; pfam13855 743720014286 Leucine rich repeat; Region: LRR_8; pfam13855 743720014287 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 743720014288 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 743720014289 active site 743720014290 ATP binding site [chemical binding]; other site 743720014291 substrate binding site [chemical binding]; other site 743720014292 activation loop (A-loop); other site 743720014293 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 743720014294 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 743720014295 metal ion-dependent adhesion site (MIDAS); other site 743720014296 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 743720014297 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 743720014298 Walker A motif; other site 743720014299 ATP binding site [chemical binding]; other site 743720014300 Walker B motif; other site 743720014301 arginine finger; other site 743720014302 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 743720014303 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 743720014304 nudix motif; other site 743720014305 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 743720014306 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 743720014307 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 743720014308 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 743720014309 Walker A/P-loop; other site 743720014310 ATP binding site [chemical binding]; other site 743720014311 Q-loop/lid; other site 743720014312 ABC transporter signature motif; other site 743720014313 Walker B; other site 743720014314 D-loop; other site 743720014315 H-loop/switch region; other site 743720014316 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 743720014317 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 743720014318 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 743720014319 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 743720014320 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 743720014321 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 743720014322 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 743720014323 Probable cobalt transporter subunit (CbtB); Region: CbtB; pfam09489 743720014324 Predicted integral membrane protein [Function unknown]; Region: COG5446 743720014325 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 743720014326 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 743720014327 active site 743720014328 SAM binding site [chemical binding]; other site 743720014329 homodimer interface [polypeptide binding]; other site 743720014330 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720014331 putative active site [active] 743720014332 heme pocket [chemical binding]; other site 743720014333 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720014334 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 743720014335 putative active site [active] 743720014336 heme pocket [chemical binding]; other site 743720014337 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 743720014338 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 743720014339 putative active site [active] 743720014340 heme pocket [chemical binding]; other site 743720014341 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 743720014342 dimer interface [polypeptide binding]; other site 743720014343 phosphorylation site [posttranslational modification] 743720014344 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 743720014345 ATP binding site [chemical binding]; other site 743720014346 Mg2+ binding site [ion binding]; other site 743720014347 G-X-G motif; other site 743720014348 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 743720014349 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720014350 active site 743720014351 phosphorylation site [posttranslational modification] 743720014352 intermolecular recognition site; other site 743720014353 dimerization interface [polypeptide binding]; other site 743720014354 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 743720014355 DNA binding residues [nucleotide binding] 743720014356 dimerization interface [polypeptide binding]; other site 743720014357 Protein of unknown function (DUF3613); Region: DUF3613; pfam12266 743720014358 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 743720014359 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 743720014360 binding surface 743720014361 TPR motif; other site 743720014362 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 743720014363 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 743720014364 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 743720014365 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 743720014366 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 743720014367 ATP binding site [chemical binding]; other site 743720014368 Walker A motif; other site 743720014369 hexamer interface [polypeptide binding]; other site 743720014370 Walker B motif; other site 743720014371 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 743720014372 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 743720014373 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 743720014374 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 743720014375 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 743720014376 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 743720014377 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 743720014378 Response regulator receiver domain; Region: Response_reg; pfam00072 743720014379 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 743720014380 active site 743720014381 phosphorylation site [posttranslational modification] 743720014382 intermolecular recognition site; other site 743720014383 dimerization interface [polypeptide binding]; other site 743720014384 Part of AAA domain; Region: AAA_19; pfam13245 743720014385 AAA domain; Region: AAA_11; pfam13086 743720014386 AAA domain; Region: AAA_11; pfam13086 743720014387 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 743720014388 AAA domain; Region: AAA_12; pfam13087 743720014389 hypothetical protein; Provisional; Region: PRK10279 743720014390 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 743720014391 active site 743720014392 nucleophile elbow; other site 743720014393 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 743720014394 Surface antigen; Region: Bac_surface_Ag; pfam01103 743720014395 Protein of unknown function (DUF1375); Region: DUF1375; pfam07119 743720014396 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 743720014397 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 743720014398 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 743720014399 putative active site [active] 743720014400 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 743720014401 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 743720014402 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 743720014403 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 743720014404 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 743720014405 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 743720014406 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 743720014407 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 743720014408 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 743720014409 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 743720014410 Outer membrane efflux protein; Region: OEP; pfam02321 743720014411 Outer membrane efflux protein; Region: OEP; pfam02321 743720014412 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 743720014413 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 743720014414 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 743720014415 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 743720014416 Walker A/P-loop; other site 743720014417 ATP binding site [chemical binding]; other site 743720014418 Q-loop/lid; other site 743720014419 ABC transporter signature motif; other site 743720014420 Walker B; other site 743720014421 D-loop; other site 743720014422 H-loop/switch region; other site 743720014423 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 743720014424 HlyD family secretion protein; Region: HlyD_3; pfam13437 743720014425 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 743720014426 Predicted membrane protein [Function unknown]; Region: COG4655 743720014427 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 743720014428 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 743720014429 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 743720014430 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 743720014431 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 743720014432 active site 743720014433 Predicted membrane protein [Function unknown]; Region: COG2364 743720014434 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 743720014435 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 743720014436 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 743720014437 glutaminase active site [active] 743720014438 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 743720014439 dimer interface [polypeptide binding]; other site 743720014440 active site 743720014441 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 743720014442 dimer interface [polypeptide binding]; other site 743720014443 active site 743720014444 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 743720014445 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 743720014446 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 743720014447 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 743720014448 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 743720014449 Substrate binding site; other site 743720014450 Mg++ binding site; other site 743720014451 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 743720014452 active site 743720014453 substrate binding site [chemical binding]; other site 743720014454 CoA binding site [chemical binding]; other site 743720014455 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 743720014456 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 743720014457 gamma subunit interface [polypeptide binding]; other site 743720014458 epsilon subunit interface [polypeptide binding]; other site 743720014459 LBP interface [polypeptide binding]; other site 743720014460 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 743720014461 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 743720014462 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 743720014463 alpha subunit interaction interface [polypeptide binding]; other site 743720014464 Walker A motif; other site 743720014465 ATP binding site [chemical binding]; other site 743720014466 Walker B motif; other site 743720014467 inhibitor binding site; inhibition site 743720014468 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 743720014469 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 743720014470 core domain interface [polypeptide binding]; other site 743720014471 delta subunit interface [polypeptide binding]; other site 743720014472 epsilon subunit interface [polypeptide binding]; other site 743720014473 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 743720014474 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 743720014475 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 743720014476 beta subunit interaction interface [polypeptide binding]; other site 743720014477 Walker A motif; other site 743720014478 ATP binding site [chemical binding]; other site 743720014479 Walker B motif; other site 743720014480 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 743720014481 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 743720014482 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 743720014483 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 743720014484 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 743720014485 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 743720014486 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 743720014487 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 743720014488 F0F1 ATP synthase subunit I; Validated; Region: PRK05760 743720014489 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 743720014490 ParB-like nuclease domain; Region: ParBc; pfam02195 743720014491 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 743720014492 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 743720014493 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 743720014494 Magnesium ion binding site [ion binding]; other site 743720014495 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 743720014496 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 743720014497 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 743720014498 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 743720014499 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 743720014500 Protein of unknown function (DUF4019); Region: DUF4019; pfam13211 743720014501 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 743720014502 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 743720014503 RHS Repeat; Region: RHS_repeat; pfam05593 743720014504 RHS Repeat; Region: RHS_repeat; pfam05593 743720014505 RHS Repeat; Region: RHS_repeat; pfam05593 743720014506 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 743720014507 RHS Repeat; Region: RHS_repeat; pfam05593 743720014508 RHS protein; Region: RHS; pfam03527 743720014509 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 743720014510 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 743720014511 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 743720014512 trmE is a tRNA modification GTPase; Region: trmE; cd04164 743720014513 G1 box; other site 743720014514 GTP/Mg2+ binding site [chemical binding]; other site 743720014515 Switch I region; other site 743720014516 G2 box; other site 743720014517 Switch II region; other site 743720014518 G3 box; other site 743720014519 G4 box; other site 743720014520 G5 box; other site 743720014521 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 743720014522 membrane protein insertase; Provisional; Region: PRK01318 743720014523 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 743720014524 hypothetical protein; Provisional; Region: PRK14371 743720014525 ribonuclease P; Reviewed; Region: rnpA; PRK00396 743720014526 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399