-- dump date   	20140620_010042
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1282356000001	Paraquat-inducible protein A; Region: PqiA; pfam04403
1282356000002	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
1282356000003	Paraquat-inducible protein A; Region: PqiA; pfam04403
1282356000004	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
1282356000005	mce related protein; Region: MCE; pfam02470
1282356000006	mce related protein; Region: MCE; pfam02470
1282356000007	mce related protein; Region: MCE; pfam02470
1282356000008	mce related protein; Region: MCE; pfam02470
1282356000009	mce related protein; Region: MCE; pfam02470
1282356000010	mce related protein; Region: MCE; pfam02470
1282356000011	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1282356000012	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1282356000013	Coenzyme A binding pocket [chemical binding]; other site
1282356000014	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
1282356000015	active site clefts [active]
1282356000016	zinc binding site [ion binding]; other site
1282356000017	dimer interface [polypeptide binding]; other site
1282356000018	acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397
1282356000019	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
1282356000020	metabolite-proton symporter; Region: 2A0106; TIGR00883
1282356000021	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356000022	GntP family permease; Region: GntP_permease; pfam02447
1282356000023	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1282356000024	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1282356000025	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1282356000026	Outer membrane efflux protein; Region: OEP; pfam02321
1282356000027	Outer membrane efflux protein; Region: OEP; pfam02321
1282356000028	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1282356000029	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
1282356000030	HlyD family secretion protein; Region: HlyD_3; pfam13437
1282356000031	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
1282356000032	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
1282356000033	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1282356000034	dimerization interface [polypeptide binding]; other site
1282356000035	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356000036	dimer interface [polypeptide binding]; other site
1282356000037	phosphorylation site [posttranslational modification]
1282356000038	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356000039	ATP binding site [chemical binding]; other site
1282356000040	Mg2+ binding site [ion binding]; other site
1282356000041	G-X-G motif; other site
1282356000042	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
1282356000043	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356000044	active site
1282356000045	phosphorylation site [posttranslational modification]
1282356000046	intermolecular recognition site; other site
1282356000047	dimerization interface [polypeptide binding]; other site
1282356000048	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1282356000049	DNA binding site [nucleotide binding]
1282356000050	outer membrane porin, OprD family; Region: OprD; pfam03573
1282356000051	Protein of unknown function (DUF2790); Region: DUF2790; pfam10976
1282356000052	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1282356000053	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1282356000054	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1282356000055	LysE type translocator; Region: LysE; cl00565
1282356000056	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
1282356000057	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1282356000058	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
1282356000059	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1282356000060	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1282356000061	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
1282356000062	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
1282356000063	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1282356000064	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1282356000065	DNA binding residues [nucleotide binding]
1282356000066	HrpJ-like domain; Region: HrpJ; cl15454
1282356000067	TyeA; Region: TyeA; cl07611
1282356000068	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
1282356000069	FHIPEP family; Region: FHIPEP; pfam00771
1282356000070	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
1282356000071	phosphopeptide binding site; other site
1282356000072	type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546
1282356000073	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1282356000074	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1282356000075	Walker A motif; other site
1282356000076	ATP binding site [chemical binding]; other site
1282356000077	Walker B motif; other site
1282356000078	type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551
1282356000079	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
1282356000080	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
1282356000081	type III secretion system protein YscR; Provisional; Region: PRK12797
1282356000082	type III secretion protein, HrpO family; Region: fliQ_rel_III; TIGR01403
1282356000083	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
1282356000084	type III secretion protein, YscU/HrpY family; Region: FlhB_rel_III; TIGR01404
1282356000085	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
1282356000086	type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516
1282356000087	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1282356000088	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1282356000089	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1282356000090	HrpE/YscL/FliH and V-type ATPase subunit E; Region: HrpE; pfam06188
1282356000091	TIGR03503 family protein; Region: TIGR03503
1282356000092	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1282356000093	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1282356000094	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1282356000095	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1282356000096	active site
1282356000097	metal binding site [ion binding]; metal-binding site
1282356000098	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1282356000099	putative DNA binding site [nucleotide binding]; other site
1282356000100	dimerization interface [polypeptide binding]; other site
1282356000101	putative Zn2+ binding site [ion binding]; other site
1282356000102	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1282356000103	Cytochrome P450; Region: p450; cl12078
1282356000104	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1282356000105	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
1282356000106	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
1282356000107	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1282356000108	ABC transporter signature motif; other site
1282356000109	Walker B; other site
1282356000110	D-loop; other site
1282356000111	H-loop/switch region; other site
1282356000112	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
1282356000113	Part of AAA domain; Region: AAA_19; pfam13245
1282356000114	Family description; Region: UvrD_C_2; pfam13538
1282356000115	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1282356000116	active site
1282356000117	DNA binding site [nucleotide binding]
1282356000118	Int/Topo IB signature motif; other site
1282356000119	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
1282356000120	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
1282356000121	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
1282356000122	RTX toxin acyltransferase family; Region: HlyC; pfam02794
1282356000123	haemagglutination activity domain; Region: Haemagg_act; pfam05860
1282356000124	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
1282356000125	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1282356000126	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1282356000127	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1282356000128	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1282356000129	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1282356000130	nudix motif; other site
1282356000131	AAA domain; Region: AAA_17; pfam13207
1282356000132	AAA domain; Region: AAA_18; pfam13238
1282356000133	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1282356000134	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1282356000135	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1282356000136	AAA domain; Region: AAA_33; pfam13671
1282356000137	active site
1282356000138	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1282356000139	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1282356000140	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1282356000141	choline dehydrogenase; Validated; Region: PRK02106
1282356000142	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1282356000143	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1282356000144	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1282356000145	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1282356000146	classical (c) SDRs; Region: SDR_c; cd05233
1282356000147	NAD(P) binding site [chemical binding]; other site
1282356000148	active site
1282356000149	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1282356000150	active site
1282356000151	DNA binding site [nucleotide binding]
1282356000152	Int/Topo IB signature motif; other site
1282356000153	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1282356000154	Protein of unknown function, DUF606; Region: DUF606; pfam04657
1282356000155	hypothetical protein; Provisional; Region: PRK08204
1282356000156	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1282356000157	active site
1282356000158	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356000159	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356000160	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
1282356000161	putative effector binding pocket; other site
1282356000162	putative dimerization interface [polypeptide binding]; other site
1282356000163	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
1282356000164	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356000165	Helix-turn-helix domain; Region: HTH_18; pfam12833
1282356000166	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1282356000167	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1282356000168	dimerization interface [polypeptide binding]; other site
1282356000169	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1282356000170	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356000171	dimer interface [polypeptide binding]; other site
1282356000172	putative CheW interface [polypeptide binding]; other site
1282356000173	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1282356000174	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
1282356000175	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1282356000176	active site
1282356000177	catalytic residues [active]
1282356000178	DNA binding site [nucleotide binding]
1282356000179	Int/Topo IB signature motif; other site
1282356000180	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
1282356000181	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
1282356000182	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1282356000183	active site
1282356000184	DNA binding site [nucleotide binding]
1282356000185	Int/Topo IB signature motif; other site
1282356000186	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
1282356000187	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356000188	Walker B motif; other site
1282356000189	arginine finger; other site
1282356000190	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
1282356000191	GTP-binding protein YchF; Reviewed; Region: PRK09601
1282356000192	YchF GTPase; Region: YchF; cd01900
1282356000193	G1 box; other site
1282356000194	GTP/Mg2+ binding site [chemical binding]; other site
1282356000195	Switch I region; other site
1282356000196	G2 box; other site
1282356000197	Switch II region; other site
1282356000198	G3 box; other site
1282356000199	G4 box; other site
1282356000200	G5 box; other site
1282356000201	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1282356000202	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1282356000203	putative active site [active]
1282356000204	catalytic residue [active]
1282356000205	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
1282356000206	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1282356000207	5S rRNA interface [nucleotide binding]; other site
1282356000208	CTC domain interface [polypeptide binding]; other site
1282356000209	L16 interface [polypeptide binding]; other site
1282356000210	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
1282356000211	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1282356000212	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1282356000213	active site
1282356000214	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
1282356000215	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1282356000216	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
1282356000217	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
1282356000218	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1282356000219	TPR motif; other site
1282356000220	binding surface
1282356000221	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1282356000222	binding surface
1282356000223	TPR motif; other site
1282356000224	TPR repeat; Region: TPR_11; pfam13414
1282356000225	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1282356000226	binding surface
1282356000227	TPR motif; other site
1282356000228	TPR repeat; Region: TPR_11; pfam13414
1282356000229	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
1282356000230	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
1282356000231	tRNA; other site
1282356000232	putative tRNA binding site [nucleotide binding]; other site
1282356000233	putative NADP binding site [chemical binding]; other site
1282356000234	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
1282356000235	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1282356000236	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1282356000237	RF-1 domain; Region: RF-1; pfam00472
1282356000238	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1282356000239	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356000240	S-adenosylmethionine binding site [chemical binding]; other site
1282356000241	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
1282356000242	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1282356000243	ATP binding site [chemical binding]; other site
1282356000244	substrate interface [chemical binding]; other site
1282356000245	glutamate racemase; Provisional; Region: PRK00865
1282356000246	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
1282356000247	Flagellin N-methylase; Region: FliB; pfam03692
1282356000248	Protein of unknown function (DUF2878); Region: DUF2878; pfam11086
1282356000249	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
1282356000250	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356000251	S-adenosylmethionine binding site [chemical binding]; other site
1282356000252	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
1282356000253	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
1282356000254	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1282356000255	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1282356000256	NAD(P) binding site [chemical binding]; other site
1282356000257	active site
1282356000258	SnoaL-like domain; Region: SnoaL_2; pfam12680
1282356000259	deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674
1282356000260	DNA photolyase; Region: DNA_photolyase; pfam00875
1282356000261	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
1282356000262	DNA binding residues [nucleotide binding]
1282356000263	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1282356000264	B12 binding domain; Region: B12-binding_2; pfam02607
1282356000265	Protein of unknown function (DUF523); Region: DUF523; pfam04463
1282356000266	Uncharacterized conserved protein [Function unknown]; Region: COG3272
1282356000267	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
1282356000268	Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493
1282356000269	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
1282356000270	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1282356000271	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
1282356000272	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1282356000273	NAD(P) binding site [chemical binding]; other site
1282356000274	active site
1282356000275	ferrochelatase; Reviewed; Region: hemH; PRK00035
1282356000276	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1282356000277	C-terminal domain interface [polypeptide binding]; other site
1282356000278	active site
1282356000279	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1282356000280	active site
1282356000281	N-terminal domain interface [polypeptide binding]; other site
1282356000282	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1282356000283	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1282356000284	N-terminal plug; other site
1282356000285	ligand-binding site [chemical binding]; other site
1282356000286	serine endoprotease; Provisional; Region: PRK10898
1282356000287	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1282356000288	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1282356000289	protein binding site [polypeptide binding]; other site
1282356000290	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1282356000291	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
1282356000292	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
1282356000293	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1282356000294	Active Sites [active]
1282356000295	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
1282356000296	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
1282356000297	CysD dimerization site [polypeptide binding]; other site
1282356000298	G1 box; other site
1282356000299	putative GEF interaction site [polypeptide binding]; other site
1282356000300	GTP/Mg2+ binding site [chemical binding]; other site
1282356000301	Switch I region; other site
1282356000302	G2 box; other site
1282356000303	G3 box; other site
1282356000304	Switch II region; other site
1282356000305	G4 box; other site
1282356000306	G5 box; other site
1282356000307	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
1282356000308	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
1282356000309	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
1282356000310	ligand-binding site [chemical binding]; other site
1282356000311	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1282356000312	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
1282356000313	putative acyl-acceptor binding pocket; other site
1282356000314	phosphate acetyltransferase; Reviewed; Region: PRK05632
1282356000315	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1282356000316	DRTGG domain; Region: DRTGG; pfam07085
1282356000317	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
1282356000318	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
1282356000319	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1282356000320	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1282356000321	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
1282356000322	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
1282356000323	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1282356000324	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1282356000325	active site
1282356000326	Riboflavin kinase; Region: Flavokinase; pfam01687
1282356000327	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
1282356000328	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1282356000329	active site
1282356000330	HIGH motif; other site
1282356000331	nucleotide binding site [chemical binding]; other site
1282356000332	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1282356000333	active site
1282356000334	KMSKS motif; other site
1282356000335	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
1282356000336	tRNA binding surface [nucleotide binding]; other site
1282356000337	anticodon binding site; other site
1282356000338	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1282356000339	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
1282356000340	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
1282356000341	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1282356000342	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
1282356000343	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
1282356000344	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
1282356000345	Type II transport protein GspH; Region: GspH; pfam12019
1282356000346	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
1282356000347	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
1282356000348	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
1282356000349	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1282356000350	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
1282356000351	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
1282356000352	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1282356000353	RNA binding surface [nucleotide binding]; other site
1282356000354	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1282356000355	active site
1282356000356	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
1282356000357	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
1282356000358	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1282356000359	Clp amino terminal domain; Region: Clp_N; pfam02861
1282356000360	Clp amino terminal domain; Region: Clp_N; pfam02861
1282356000361	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356000362	Walker A motif; other site
1282356000363	ATP binding site [chemical binding]; other site
1282356000364	Walker B motif; other site
1282356000365	arginine finger; other site
1282356000366	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356000367	Walker A motif; other site
1282356000368	ATP binding site [chemical binding]; other site
1282356000369	Walker B motif; other site
1282356000370	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1282356000371	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1282356000372	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1282356000373	Protein of unknown function (DUF1780); Region: DUF1780; pfam08682
1282356000374	DNA gyrase inhibitor; Reviewed; Region: PRK00418
1282356000375	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1282356000376	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1282356000377	CoA-binding site [chemical binding]; other site
1282356000378	ATP-binding [chemical binding]; other site
1282356000379	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
1282356000380	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
1282356000381	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
1282356000382	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
1282356000383	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1282356000384	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1282356000385	Pilin (bacterial filament); Region: Pilin; pfam00114
1282356000386	O-Antigen ligase; Region: Wzy_C; pfam04932
1282356000387	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1282356000388	putative trimer interface [polypeptide binding]; other site
1282356000389	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1282356000390	putative CoA binding site [chemical binding]; other site
1282356000391	putative trimer interface [polypeptide binding]; other site
1282356000392	putative CoA binding site [chemical binding]; other site
1282356000393	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1282356000394	putative trimer interface [polypeptide binding]; other site
1282356000395	putative CoA binding site [chemical binding]; other site
1282356000396	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05742
1282356000397	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
1282356000398	dimerization interface [polypeptide binding]; other site
1282356000399	active site
1282356000400	Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
1282356000401	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
1282356000402	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1282356000403	amidase catalytic site [active]
1282356000404	Zn binding residues [ion binding]; other site
1282356000405	substrate binding site [chemical binding]; other site
1282356000406	Membrane protein required for beta-lactamase induction [Defense mechanisms]; Region: AmpE; cl17896
1282356000407	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1282356000408	active site
1282356000409	DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303
1282356000410	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1282356000411	DNA binding site [nucleotide binding]
1282356000412	domain linker motif; other site
1282356000413	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1282356000414	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109
1282356000415	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1282356000416	active site
1282356000417	phosphorylation site [posttranslational modification]
1282356000418	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359
1282356000419	active site
1282356000420	phosphorylation site [posttranslational modification]
1282356000421	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1282356000422	dimerization domain swap beta strand [polypeptide binding]; other site
1282356000423	regulatory protein interface [polypeptide binding]; other site
1282356000424	active site
1282356000425	regulatory phosphorylation site [posttranslational modification]; other site
1282356000426	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1282356000427	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1282356000428	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1282356000429	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1282356000430	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
1282356000431	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1282356000432	putative substrate binding site [chemical binding]; other site
1282356000433	putative ATP binding site [chemical binding]; other site
1282356000434	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
1282356000435	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1282356000436	active site
1282356000437	P-loop; other site
1282356000438	phosphorylation site [posttranslational modification]
1282356000439	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1282356000440	active site
1282356000441	P-loop; other site
1282356000442	phosphorylation site [posttranslational modification]
1282356000443	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
1282356000444	Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540
1282356000445	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
1282356000446	putative active site [active]
1282356000447	putative metal binding site [ion binding]; other site
1282356000448	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1282356000449	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1282356000450	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
1282356000451	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1282356000452	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
1282356000453	Flavodoxin; Region: Flavodoxin_1; pfam00258
1282356000454	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
1282356000455	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200
1282356000456	FAD binding pocket [chemical binding]; other site
1282356000457	FAD binding motif [chemical binding]; other site
1282356000458	catalytic residues [active]
1282356000459	NAD binding pocket [chemical binding]; other site
1282356000460	phosphate binding motif [ion binding]; other site
1282356000461	beta-alpha-beta structure motif; other site
1282356000462	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
1282356000463	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
1282356000464	dimer interface [polypeptide binding]; other site
1282356000465	active site
1282356000466	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1282356000467	catalytic residues [active]
1282356000468	substrate binding site [chemical binding]; other site
1282356000469	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1282356000470	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
1282356000471	Walker A/P-loop; other site
1282356000472	ATP binding site [chemical binding]; other site
1282356000473	Q-loop/lid; other site
1282356000474	ABC transporter signature motif; other site
1282356000475	Walker B; other site
1282356000476	D-loop; other site
1282356000477	H-loop/switch region; other site
1282356000478	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1282356000479	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356000480	dimer interface [polypeptide binding]; other site
1282356000481	conserved gate region; other site
1282356000482	ABC-ATPase subunit interface; other site
1282356000483	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1282356000484	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
1282356000485	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356000486	dimer interface [polypeptide binding]; other site
1282356000487	conserved gate region; other site
1282356000488	putative PBP binding loops; other site
1282356000489	ABC-ATPase subunit interface; other site
1282356000490	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
1282356000491	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
1282356000492	G1 box; other site
1282356000493	putative GEF interaction site [polypeptide binding]; other site
1282356000494	GTP/Mg2+ binding site [chemical binding]; other site
1282356000495	Switch I region; other site
1282356000496	G2 box; other site
1282356000497	G3 box; other site
1282356000498	Switch II region; other site
1282356000499	G4 box; other site
1282356000500	G5 box; other site
1282356000501	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
1282356000502	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
1282356000503	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1282356000504	Walker A/P-loop; other site
1282356000505	ATP binding site [chemical binding]; other site
1282356000506	Q-loop/lid; other site
1282356000507	ABC transporter signature motif; other site
1282356000508	Walker B; other site
1282356000509	D-loop; other site
1282356000510	H-loop/switch region; other site
1282356000511	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1282356000512	dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022
1282356000513	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1282356000514	Walker A/P-loop; other site
1282356000515	ATP binding site [chemical binding]; other site
1282356000516	Q-loop/lid; other site
1282356000517	ABC transporter signature motif; other site
1282356000518	Walker B; other site
1282356000519	D-loop; other site
1282356000520	H-loop/switch region; other site
1282356000521	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1282356000522	dipeptide transporter; Provisional; Region: PRK10913
1282356000523	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1282356000524	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356000525	dimer interface [polypeptide binding]; other site
1282356000526	conserved gate region; other site
1282356000527	putative PBP binding loops; other site
1282356000528	ABC-ATPase subunit interface; other site
1282356000529	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1282356000530	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356000531	dimer interface [polypeptide binding]; other site
1282356000532	conserved gate region; other site
1282356000533	putative PBP binding loops; other site
1282356000534	ABC-ATPase subunit interface; other site
1282356000535	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1282356000536	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
1282356000537	peptide binding site [polypeptide binding]; other site
1282356000538	outer membrane porin, OprD family; Region: OprD; pfam03573
1282356000539	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1282356000540	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
1282356000541	peptide binding site [polypeptide binding]; other site
1282356000542	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1282356000543	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
1282356000544	peptide binding site [polypeptide binding]; other site
1282356000545	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1282356000546	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
1282356000547	peptide binding site [polypeptide binding]; other site
1282356000548	Protein of unknown function (DUF541); Region: SIMPL; cl01077
1282356000549	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1282356000550	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356000551	ATP binding site [chemical binding]; other site
1282356000552	G-X-G motif; other site
1282356000553	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
1282356000554	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356000555	active site
1282356000556	phosphorylation site [posttranslational modification]
1282356000557	intermolecular recognition site; other site
1282356000558	dimerization interface [polypeptide binding]; other site
1282356000559	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1282356000560	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
1282356000561	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
1282356000562	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
1282356000563	Protein of unknown function (DUF1043); Region: DUF1043; cl11473
1282356000564	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
1282356000565	Chlamydia CHLPS protein (DUF818); Region: DUF818; pfam05677
1282356000566	tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284
1282356000567	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1282356000568	active site
1282356000569	HIGH motif; other site
1282356000570	dimer interface [polypeptide binding]; other site
1282356000571	KMSKS motif; other site
1282356000572	Predicted ATPase [General function prediction only]; Region: COG1485
1282356000573	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1282356000574	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
1282356000575	conserved cys residue [active]
1282356000576	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1282356000577	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1282356000578	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1282356000579	active site
1282356000580	catalytic tetrad [active]
1282356000581	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1282356000582	23S rRNA interface [nucleotide binding]; other site
1282356000583	L3 interface [polypeptide binding]; other site
1282356000584	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1282356000585	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
1282356000586	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
1282356000587	[2Fe-2S] cluster binding site [ion binding]; other site
1282356000588	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
1282356000589	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
1282356000590	Qi binding site; other site
1282356000591	intrachain domain interface; other site
1282356000592	interchain domain interface [polypeptide binding]; other site
1282356000593	heme bH binding site [chemical binding]; other site
1282356000594	heme bL binding site [chemical binding]; other site
1282356000595	Qo binding site; other site
1282356000596	interchain domain interface [polypeptide binding]; other site
1282356000597	intrachain domain interface; other site
1282356000598	Qi binding site; other site
1282356000599	Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032
1282356000600	Qo binding site; other site
1282356000601	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
1282356000602	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
1282356000603	stringent starvation protein A; Provisional; Region: sspA; PRK09481
1282356000604	C-terminal domain interface [polypeptide binding]; other site
1282356000605	putative GSH binding site (G-site) [chemical binding]; other site
1282356000606	dimer interface [polypeptide binding]; other site
1282356000607	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
1282356000608	dimer interface [polypeptide binding]; other site
1282356000609	N-terminal domain interface [polypeptide binding]; other site
1282356000610	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
1282356000611	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1282356000612	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1282356000613	DNA-binding site [nucleotide binding]; DNA binding site
1282356000614	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1282356000615	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1282356000616	5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
1282356000617	putative active site [active]
1282356000618	catalytic residue [active]
1282356000619	Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
1282356000620	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1282356000621	NAD(P) binding site [chemical binding]; other site
1282356000622	catalytic residues [active]
1282356000623	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356000624	D-galactonate transporter; Region: 2A0114; TIGR00893
1282356000625	putative substrate translocation pore; other site
1282356000626	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356000627	galactarate dehydratase; Region: galactar-dH20; TIGR03248
1282356000628	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
1282356000629	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
1282356000630	Predicted permeases [General function prediction only]; Region: COG0679
1282356000631	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
1282356000632	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
1282356000633	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1282356000634	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1282356000635	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
1282356000636	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
1282356000637	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1282356000638	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1282356000639	GatB domain; Region: GatB_Yqey; smart00845
1282356000640	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1282356000641	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1282356000642	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
1282356000643	rod shape-determining protein MreB; Provisional; Region: PRK13927
1282356000644	MreB and similar proteins; Region: MreB_like; cd10225
1282356000645	nucleotide binding site [chemical binding]; other site
1282356000646	Mg binding site [ion binding]; other site
1282356000647	putative protofilament interaction site [polypeptide binding]; other site
1282356000648	RodZ interaction site [polypeptide binding]; other site
1282356000649	rod shape-determining protein MreC; Provisional; Region: PRK13922
1282356000650	rod shape-determining protein MreC; Region: MreC; pfam04085
1282356000651	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
1282356000652	Maf-like protein; Region: Maf; pfam02545
1282356000653	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1282356000654	active site
1282356000655	dimer interface [polypeptide binding]; other site
1282356000656	ribonuclease G; Provisional; Region: PRK11712
1282356000657	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1282356000658	homodimer interface [polypeptide binding]; other site
1282356000659	oligonucleotide binding site [chemical binding]; other site
1282356000660	TIGR02099 family protein; Region: TIGR02099
1282356000661	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1282356000662	nitrilase; Region: PLN02798
1282356000663	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
1282356000664	putative active site [active]
1282356000665	catalytic triad [active]
1282356000666	dimer interface [polypeptide binding]; other site
1282356000667	protease TldD; Provisional; Region: tldD; PRK10735
1282356000668	hypothetical protein; Provisional; Region: PRK05255
1282356000669	peptidase PmbA; Provisional; Region: PRK11040
1282356000670	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1282356000671	Class II fumarases; Region: Fumarase_classII; cd01362
1282356000672	active site
1282356000673	tetramer interface [polypeptide binding]; other site
1282356000674	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1282356000675	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1282356000676	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1282356000677	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
1282356000678	ZIP Zinc transporter; Region: Zip; pfam02535
1282356000679	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1282356000680	dimerization domain swap beta strand [polypeptide binding]; other site
1282356000681	regulatory protein interface [polypeptide binding]; other site
1282356000682	active site
1282356000683	regulatory phosphorylation site [posttranslational modification]; other site
1282356000684	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
1282356000685	AAA domain; Region: AAA_18; pfam13238
1282356000686	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1282356000687	active site
1282356000688	phosphorylation site [posttranslational modification]
1282356000689	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1282356000690	30S subunit binding site; other site
1282356000691	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
1282356000692	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
1282356000693	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
1282356000694	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
1282356000695	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
1282356000696	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
1282356000697	Walker A/P-loop; other site
1282356000698	ATP binding site [chemical binding]; other site
1282356000699	Q-loop/lid; other site
1282356000700	ABC transporter signature motif; other site
1282356000701	Walker B; other site
1282356000702	D-loop; other site
1282356000703	H-loop/switch region; other site
1282356000704	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
1282356000705	OstA-like protein; Region: OstA; pfam03968
1282356000706	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117
1282356000707	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
1282356000708	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
1282356000709	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1282356000710	active site
1282356000711	motif I; other site
1282356000712	motif II; other site
1282356000713	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
1282356000714	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
1282356000715	putative active site [active]
1282356000716	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
1282356000717	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
1282356000718	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
1282356000719	Walker A/P-loop; other site
1282356000720	ATP binding site [chemical binding]; other site
1282356000721	Q-loop/lid; other site
1282356000722	ABC transporter signature motif; other site
1282356000723	Walker B; other site
1282356000724	D-loop; other site
1282356000725	H-loop/switch region; other site
1282356000726	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1282356000727	Permease; Region: Permease; cl00510
1282356000728	mce related protein; Region: MCE; pfam02470
1282356000729	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
1282356000730	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
1282356000731	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1282356000732	anti sigma factor interaction site; other site
1282356000733	regulatory phosphorylation site [posttranslational modification]; other site
1282356000734	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
1282356000735	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1282356000736	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1282356000737	hinge; other site
1282356000738	active site
1282356000739	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
1282356000740	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
1282356000741	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
1282356000742	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1282356000743	NAD binding site [chemical binding]; other site
1282356000744	dimerization interface [polypeptide binding]; other site
1282356000745	product binding site; other site
1282356000746	substrate binding site [chemical binding]; other site
1282356000747	zinc binding site [ion binding]; other site
1282356000748	catalytic residues [active]
1282356000749	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
1282356000750	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1282356000751	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356000752	homodimer interface [polypeptide binding]; other site
1282356000753	catalytic residue [active]
1282356000754	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
1282356000755	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1282356000756	active site
1282356000757	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1282356000758	active site
1282356000759	cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366
1282356000760	malate:quinone oxidoreductase; Reviewed; Region: PRK13339
1282356000761	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
1282356000762	hypothetical protein; Provisional; Region: PRK11627
1282356000763	Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923
1282356000764	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
1282356000765	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1282356000766	putative acyl-acceptor binding pocket; other site
1282356000767	Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255
1282356000768	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
1282356000769	Uncharacterized conserved protein [Function unknown]; Region: COG2135
1282356000770	Peptidase family M48; Region: Peptidase_M48; pfam01435
1282356000771	Predicted membrane protein [Function unknown]; Region: COG2119
1282356000772	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
1282356000773	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
1282356000774	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
1282356000775	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
1282356000776	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356000777	S-adenosylmethionine binding site [chemical binding]; other site
1282356000778	glycerate dehydrogenase; Provisional; Region: PRK06487
1282356000779	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
1282356000780	putative ligand binding site [chemical binding]; other site
1282356000781	putative NAD binding site [chemical binding]; other site
1282356000782	catalytic site [active]
1282356000783	LysE type translocator; Region: LysE; cl00565
1282356000784	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
1282356000785	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1282356000786	acyl-activating enzyme (AAE) consensus motif; other site
1282356000787	AMP binding site [chemical binding]; other site
1282356000788	active site
1282356000789	CoA binding site [chemical binding]; other site
1282356000790	Protein of unknown function (DUF1302); Region: DUF1302; pfam06980
1282356000791	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
1282356000792	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
1282356000793	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1282356000794	DNA binding residues [nucleotide binding]
1282356000795	dimerization interface [polypeptide binding]; other site
1282356000796	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
1282356000797	HipA-like N-terminal domain; Region: HipA_N; pfam07805
1282356000798	HipA-like C-terminal domain; Region: HipA_C; pfam07804
1282356000799	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1282356000800	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1282356000801	non-specific DNA binding site [nucleotide binding]; other site
1282356000802	salt bridge; other site
1282356000803	sequence-specific DNA binding site [nucleotide binding]; other site
1282356000804	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1282356000805	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1282356000806	ligand binding site [chemical binding]; other site
1282356000807	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
1282356000808	BON domain; Region: BON; pfam04972
1282356000809	BON domain; Region: BON; pfam04972
1282356000810	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
1282356000811	dimer interface [polypeptide binding]; other site
1282356000812	active site
1282356000813	hypothetical protein; Reviewed; Region: PRK12497
1282356000814	LppC putative lipoprotein; Region: LppC; pfam04348
1282356000815	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
1282356000816	putative ligand binding site [chemical binding]; other site
1282356000817	Predicted methyltransferases [General function prediction only]; Region: COG0313
1282356000818	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1282356000819	putative SAM binding site [chemical binding]; other site
1282356000820	putative homodimer interface [polypeptide binding]; other site
1282356000821	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
1282356000822	MraZ protein; Region: MraZ; pfam02381
1282356000823	MraZ protein; Region: MraZ; pfam02381
1282356000824	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
1282356000825	MraW methylase family; Region: Methyltransf_5; cl17771
1282356000826	Cell division protein FtsL; Region: FtsL; pfam04999
1282356000827	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1282356000828	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1282356000829	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1282356000830	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1282356000831	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1282356000832	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1282356000833	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1282356000834	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1282356000835	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
1282356000836	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1282356000837	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1282356000838	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1282356000839	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1282356000840	Mg++ binding site [ion binding]; other site
1282356000841	putative catalytic motif [active]
1282356000842	putative substrate binding site [chemical binding]; other site
1282356000843	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803
1282356000844	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1282356000845	cell division protein FtsW; Region: ftsW; TIGR02614
1282356000846	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1282356000847	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1282356000848	active site
1282356000849	homodimer interface [polypeptide binding]; other site
1282356000850	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1282356000851	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1282356000852	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1282356000853	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1282356000854	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
1282356000855	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1282356000856	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1282356000857	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
1282356000858	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1282356000859	Cell division protein FtsQ; Region: FtsQ; pfam03799
1282356000860	cell division protein FtsA; Region: ftsA; TIGR01174
1282356000861	Cell division protein FtsA; Region: FtsA; smart00842
1282356000862	Cell division protein FtsA; Region: FtsA; pfam14450
1282356000863	cell division protein FtsZ; Validated; Region: PRK09330
1282356000864	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1282356000865	nucleotide binding site [chemical binding]; other site
1282356000866	SulA interaction site; other site
1282356000867	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
1282356000868	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
1282356000869	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1282356000870	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1282356000871	metal binding site [ion binding]; metal-binding site
1282356000872	active site
1282356000873	I-site; other site
1282356000874	outer membrane porin, OprD family; Region: OprD; pfam03573
1282356000875	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
1282356000876	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356000877	dimer interface [polypeptide binding]; other site
1282356000878	phosphorylation site [posttranslational modification]
1282356000879	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356000880	ATP binding site [chemical binding]; other site
1282356000881	Mg2+ binding site [ion binding]; other site
1282356000882	G-X-G motif; other site
1282356000883	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
1282356000884	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356000885	active site
1282356000886	phosphorylation site [posttranslational modification]
1282356000887	intermolecular recognition site; other site
1282356000888	dimerization interface [polypeptide binding]; other site
1282356000889	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1282356000890	DNA binding site [nucleotide binding]
1282356000891	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
1282356000892	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1282356000893	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1282356000894	HlyD family secretion protein; Region: HlyD_3; pfam13437
1282356000895	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
1282356000896	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1282356000897	substrate binding pocket [chemical binding]; other site
1282356000898	membrane-bound complex binding site; other site
1282356000899	hinge residues; other site
1282356000900	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1282356000901	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1282356000902	substrate binding pocket [chemical binding]; other site
1282356000903	membrane-bound complex binding site; other site
1282356000904	hinge residues; other site
1282356000905	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1282356000906	homotrimer interaction site [polypeptide binding]; other site
1282356000907	putative active site [active]
1282356000908	Flagellin N-methylase; Region: FliB; pfam03692
1282356000909	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1282356000910	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1282356000911	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
1282356000912	Response regulator receiver domain; Region: Response_reg; pfam00072
1282356000913	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356000914	active site
1282356000915	phosphorylation site [posttranslational modification]
1282356000916	intermolecular recognition site; other site
1282356000917	dimerization interface [polypeptide binding]; other site
1282356000918	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
1282356000919	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
1282356000920	dimerization interface [polypeptide binding]; other site
1282356000921	ligand binding site [chemical binding]; other site
1282356000922	NADP binding site [chemical binding]; other site
1282356000923	catalytic site [active]
1282356000924	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356000925	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356000926	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1282356000927	putative effector binding pocket; other site
1282356000928	dimerization interface [polypeptide binding]; other site
1282356000929	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1282356000930	Fusaric acid resistance protein family; Region: FUSC; pfam04632
1282356000931	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1282356000932	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
1282356000933	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1282356000934	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1282356000935	HlyD family secretion protein; Region: HlyD_3; pfam13437
1282356000936	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1282356000937	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1282356000938	HlyD family secretion protein; Region: HlyD_3; pfam13437
1282356000939	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1282356000940	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1282356000941	Walker A/P-loop; other site
1282356000942	ATP binding site [chemical binding]; other site
1282356000943	Q-loop/lid; other site
1282356000944	ABC transporter signature motif; other site
1282356000945	Walker B; other site
1282356000946	D-loop; other site
1282356000947	H-loop/switch region; other site
1282356000948	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1282356000949	Outer membrane efflux protein; Region: OEP; pfam02321
1282356000950	Outer membrane efflux protein; Region: OEP; pfam02321
1282356000951	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460
1282356000952	short chain dehydrogenase; Provisional; Region: PRK05693
1282356000953	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1282356000954	NAD(P) binding site [chemical binding]; other site
1282356000955	active site
1282356000956	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
1282356000957	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
1282356000958	Substrate binding site; other site
1282356000959	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
1282356000960	Alginate O-acetyl transferase AlgF; Region: AlgF; pfam11182
1282356000961	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
1282356000962	Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cd00244
1282356000963	active site
1282356000964	Right handed beta helix region; Region: Beta_helix; pfam13229
1282356000965	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
1282356000966	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1282356000967	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1282356000968	PilZ domain; Region: PilZ; pfam07238
1282356000969	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
1282356000970	HlyD family secretion protein; Region: HlyD_3; pfam13437
1282356000971	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1282356000972	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
1282356000973	nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026
1282356000974	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1282356000975	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1282356000976	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1282356000977	hypothetical protein; Validated; Region: PRK02101
1282356000978	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1282356000979	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
1282356000980	NodB motif; other site
1282356000981	active site
1282356000982	catalytic site [active]
1282356000983	metal binding site [ion binding]; metal-binding site
1282356000984	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
1282356000985	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
1282356000986	putative active site [active]
1282356000987	PhoH-like protein; Region: PhoH; pfam02562
1282356000988	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
1282356000989	trimer interface [polypeptide binding]; other site
1282356000990	dimer interface [polypeptide binding]; other site
1282356000991	putative active site [active]
1282356000992	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1282356000993	MoaE interaction surface [polypeptide binding]; other site
1282356000994	MoeB interaction surface [polypeptide binding]; other site
1282356000995	thiocarboxylated glycine; other site
1282356000996	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1282356000997	MoaE homodimer interface [polypeptide binding]; other site
1282356000998	MoaD interaction [polypeptide binding]; other site
1282356000999	active site residues [active]
1282356001000	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1282356001001	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1282356001002	ATP binding site [chemical binding]; other site
1282356001003	Mg++ binding site [ion binding]; other site
1282356001004	motif III; other site
1282356001005	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1282356001006	nucleotide binding region [chemical binding]; other site
1282356001007	ATP-binding site [chemical binding]; other site
1282356001008	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
1282356001009	putative hydrolase; Provisional; Region: PRK11460
1282356001010	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1282356001011	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1282356001012	substrate binding pocket [chemical binding]; other site
1282356001013	membrane-bound complex binding site; other site
1282356001014	hinge residues; other site
1282356001015	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
1282356001016	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356001017	conserved gate region; other site
1282356001018	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356001019	dimer interface [polypeptide binding]; other site
1282356001020	ABC-ATPase subunit interface; other site
1282356001021	putative PBP binding loops; other site
1282356001022	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356001023	dimer interface [polypeptide binding]; other site
1282356001024	conserved gate region; other site
1282356001025	putative PBP binding loops; other site
1282356001026	ABC-ATPase subunit interface; other site
1282356001027	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1282356001028	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1282356001029	Walker A/P-loop; other site
1282356001030	ATP binding site [chemical binding]; other site
1282356001031	Q-loop/lid; other site
1282356001032	ABC transporter signature motif; other site
1282356001033	Walker B; other site
1282356001034	D-loop; other site
1282356001035	H-loop/switch region; other site
1282356001036	cyanate transporter; Region: CynX; TIGR00896
1282356001037	Protein of unknown function (DUF1120); Region: DUF1120; cl05856
1282356001038	hypothetical protein; Provisional; Region: PRK15301
1282356001039	Protein of unknown function (DUF1120); Region: DUF1120; cl05856
1282356001040	PapC N-terminal domain; Region: PapC_N; pfam13954
1282356001041	putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304
1282356001042	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
1282356001043	PapC C-terminal domain; Region: PapC_C; pfam13953
1282356001044	putative fimbrial chaperone protein; Provisional; Region: PRK09918
1282356001045	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1282356001046	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
1282356001047	Protein of unknown function (DUF1120); Region: DUF1120; cl05856
1282356001048	Protein of unknown function (DUF1120); Region: DUF1120; cl05856
1282356001049	Protein of unknown function (DUF1120); Region: DUF1120; cl05856
1282356001050	Protein of unknown function (DUF1120); Region: DUF1120; cl05856
1282356001051	Protein of unknown function (DUF1120); Region: DUF1120; cl05856
1282356001052	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1282356001053	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356001054	active site
1282356001055	phosphorylation site [posttranslational modification]
1282356001056	intermolecular recognition site; other site
1282356001057	dimerization interface [polypeptide binding]; other site
1282356001058	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1282356001059	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356001060	active site
1282356001061	phosphorylation site [posttranslational modification]
1282356001062	intermolecular recognition site; other site
1282356001063	dimerization interface [polypeptide binding]; other site
1282356001064	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1282356001065	DNA binding residues [nucleotide binding]
1282356001066	dimerization interface [polypeptide binding]; other site
1282356001067	SnoaL-like domain; Region: SnoaL_3; pfam13474
1282356001068	SnoaL-like domain; Region: SnoaL_2; pfam12680
1282356001069	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
1282356001070	GIY-YIG motif/motif A; other site
1282356001071	putative active site [active]
1282356001072	putative metal binding site [ion binding]; other site
1282356001073	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1282356001074	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
1282356001075	C-terminal domain interface [polypeptide binding]; other site
1282356001076	GSH binding site (G-site) [chemical binding]; other site
1282356001077	dimer interface [polypeptide binding]; other site
1282356001078	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
1282356001079	substrate binding pocket (H-site) [chemical binding]; other site
1282356001080	N-terminal domain interface [polypeptide binding]; other site
1282356001081	Secretin and TonB N terminus short domain; Region: STN; smart00965
1282356001082	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1282356001083	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1282356001084	N-terminal plug; other site
1282356001085	ligand-binding site [chemical binding]; other site
1282356001086	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113
1282356001087	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1282356001088	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1282356001089	Bacterial transcriptional regulator; Region: IclR; pfam01614
1282356001090	homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341
1282356001091	fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266
1282356001092	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
1282356001093	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1282356001094	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1282356001095	maleylacetoacetate isomerase; Region: maiA; TIGR01262
1282356001096	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
1282356001097	dimer interface [polypeptide binding]; other site
1282356001098	N-terminal domain interface [polypeptide binding]; other site
1282356001099	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
1282356001100	Uncharacterized conserved protein [Function unknown]; Region: COG2912
1282356001101	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
1282356001102	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1282356001103	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1282356001104	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
1282356001105	NAD binding site [chemical binding]; other site
1282356001106	Phe binding site; other site
1282356001107	YebG protein; Region: YebG; cl01217
1282356001108	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1282356001109	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
1282356001110	Domain of unknown function (DUF1737); Region: DUF1737; pfam08410
1282356001111	H+ Antiporter protein; Region: 2A0121; TIGR00900
1282356001112	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
1282356001113	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
1282356001114	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
1282356001115	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1282356001116	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356001117	homodimer interface [polypeptide binding]; other site
1282356001118	catalytic residue [active]
1282356001119	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1282356001120	active site
1282356001121	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
1282356001122	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
1282356001123	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1282356001124	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356001125	homodimer interface [polypeptide binding]; other site
1282356001126	catalytic residue [active]
1282356001127	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
1282356001128	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1282356001129	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1282356001130	catalytic residue [active]
1282356001131	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
1282356001132	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
1282356001133	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1282356001134	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356001135	homodimer interface [polypeptide binding]; other site
1282356001136	catalytic residue [active]
1282356001137	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1282356001138	phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297
1282356001139	PYR/PP interface [polypeptide binding]; other site
1282356001140	dimer interface [polypeptide binding]; other site
1282356001141	TPP binding site [chemical binding]; other site
1282356001142	Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as...; Region: TPP_PpyrDC; cd03371
1282356001143	TPP-binding site; other site
1282356001144	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1282356001145	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1282356001146	tetramer interface [polypeptide binding]; other site
1282356001147	active site
1282356001148	Mg2+/Mn2+ binding site [ion binding]; other site
1282356001149	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1282356001150	Transposase; Region: HTH_Tnp_1; pfam01527
1282356001151	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1282356001152	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1282356001153	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1282356001154	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
1282356001155	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1282356001156	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
1282356001157	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1282356001158	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
1282356001159	Lipase (class 2); Region: Lipase_2; pfam01674
1282356001160	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1282356001161	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1282356001162	catalytic site [active]
1282356001163	Serine hydrolase; Region: Ser_hydrolase; pfam06821
1282356001164	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1282356001165	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1282356001166	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1282356001167	putative DNA binding site [nucleotide binding]; other site
1282356001168	putative Zn2+ binding site [ion binding]; other site
1282356001169	AsnC family; Region: AsnC_trans_reg; pfam01037
1282356001170	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1282356001171	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1282356001172	DNA-binding site [nucleotide binding]; DNA binding site
1282356001173	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1282356001174	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356001175	homodimer interface [polypeptide binding]; other site
1282356001176	catalytic residue [active]
1282356001177	YqcI/YcgG family; Region: YqcI_YcgG; cl01349
1282356001178	Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999
1282356001179	active site
1282356001180	Mn binding site [ion binding]; other site
1282356001181	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
1282356001182	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1282356001183	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1282356001184	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1282356001185	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1282356001186	dimer interface [polypeptide binding]; other site
1282356001187	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356001188	catalytic residue [active]
1282356001189	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
1282356001190	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
1282356001191	Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324
1282356001192	short chain dehydrogenase; Provisional; Region: PRK08219
1282356001193	NADP binding site [chemical binding]; other site
1282356001194	substrate binding site [chemical binding]; other site
1282356001195	active site
1282356001196	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1282356001197	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1282356001198	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1282356001199	Walker A/P-loop; other site
1282356001200	ATP binding site [chemical binding]; other site
1282356001201	Q-loop/lid; other site
1282356001202	ABC transporter signature motif; other site
1282356001203	Walker B; other site
1282356001204	D-loop; other site
1282356001205	H-loop/switch region; other site
1282356001206	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1282356001207	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1282356001208	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1282356001209	Walker A/P-loop; other site
1282356001210	ATP binding site [chemical binding]; other site
1282356001211	Q-loop/lid; other site
1282356001212	ABC transporter signature motif; other site
1282356001213	Walker B; other site
1282356001214	D-loop; other site
1282356001215	H-loop/switch region; other site
1282356001216	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1282356001217	D-ala-D-ala transporter subunit; Provisional; Region: PRK09881
1282356001218	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1282356001219	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356001220	dimer interface [polypeptide binding]; other site
1282356001221	conserved gate region; other site
1282356001222	putative PBP binding loops; other site
1282356001223	ABC-ATPase subunit interface; other site
1282356001224	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1282356001225	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356001226	dimer interface [polypeptide binding]; other site
1282356001227	conserved gate region; other site
1282356001228	putative PBP binding loops; other site
1282356001229	ABC-ATPase subunit interface; other site
1282356001230	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1282356001231	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
1282356001232	D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178
1282356001233	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1282356001234	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1282356001235	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
1282356001236	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1282356001237	YebG protein; Region: YebG; pfam07130
1282356001238	Predicted membrane protein [Function unknown]; Region: COG3223
1282356001239	Predicted membrane protein [Function unknown]; Region: COG3223
1282356001240	TIGR02646 family protein; Region: TIGR02646
1282356001241	Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950
1282356001242	Phosphate-starvation-inducible E; Region: PsiE; cl01264
1282356001243	Protein of unknown function (DUF3509); Region: DUF3509; pfam12021
1282356001244	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
1282356001245	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1282356001246	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1282356001247	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356001248	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1282356001249	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1282356001250	dimerization interface [polypeptide binding]; other site
1282356001251	substrate binding pocket [chemical binding]; other site
1282356001252	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250
1282356001253	30S subunit binding site; other site
1282356001254	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
1282356001255	Secretin and TonB N terminus short domain; Region: STN; smart00965
1282356001256	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1282356001257	N-terminal plug; other site
1282356001258	ligand-binding site [chemical binding]; other site
1282356001259	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
1282356001260	FecR protein; Region: FecR; pfam04773
1282356001261	RNA polymerase sigma factor; Provisional; Region: PRK12528
1282356001262	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1282356001263	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1282356001264	DNA binding residues [nucleotide binding]
1282356001265	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1282356001266	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
1282356001267	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1282356001268	Protein of unknown function (DUF3325); Region: DUF3325; pfam11804
1282356001269	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
1282356001270	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1282356001271	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1282356001272	DNA binding residues [nucleotide binding]
1282356001273	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
1282356001274	FecR protein; Region: FecR; pfam04773
1282356001275	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1282356001276	catalytic residues [active]
1282356001277	Nucleoid-associated protein [General function prediction only]; Region: COG3081
1282356001278	nucleoid-associated protein NdpA; Validated; Region: PRK00378
1282356001279	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1282356001280	IHF - DNA interface [nucleotide binding]; other site
1282356001281	IHF dimer interface [polypeptide binding]; other site
1282356001282	Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971
1282356001283	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356001284	S-adenosylmethionine binding site [chemical binding]; other site
1282356001285	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1282356001286	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1282356001287	HIGH motif; other site
1282356001288	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1282356001289	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1282356001290	active site
1282356001291	KMSKS motif; other site
1282356001292	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1282356001293	tRNA binding surface [nucleotide binding]; other site
1282356001294	anticodon binding site; other site
1282356001295	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1282356001296	DNA polymerase III subunit chi; Validated; Region: PRK05728
1282356001297	multifunctional aminopeptidase A; Provisional; Region: PRK00913
1282356001298	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1282356001299	interface (dimer of trimers) [polypeptide binding]; other site
1282356001300	Substrate-binding/catalytic site; other site
1282356001301	Zn-binding sites [ion binding]; other site
1282356001302	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
1282356001303	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1282356001304	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
1282356001305	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1282356001306	GTP-binding protein LepA; Provisional; Region: PRK05433
1282356001307	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1282356001308	G1 box; other site
1282356001309	putative GEF interaction site [polypeptide binding]; other site
1282356001310	GTP/Mg2+ binding site [chemical binding]; other site
1282356001311	Switch I region; other site
1282356001312	G2 box; other site
1282356001313	G3 box; other site
1282356001314	Switch II region; other site
1282356001315	G4 box; other site
1282356001316	G5 box; other site
1282356001317	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1282356001318	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1282356001319	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1282356001320	signal peptidase I; Provisional; Region: PRK10861
1282356001321	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1282356001322	Catalytic site [active]
1282356001323	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1282356001324	ribonuclease III; Reviewed; Region: rnc; PRK00102
1282356001325	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1282356001326	dimerization interface [polypeptide binding]; other site
1282356001327	active site
1282356001328	metal binding site [ion binding]; metal-binding site
1282356001329	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1282356001330	dsRNA binding site [nucleotide binding]; other site
1282356001331	GTPase Era; Reviewed; Region: era; PRK00089
1282356001332	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1282356001333	G1 box; other site
1282356001334	GTP/Mg2+ binding site [chemical binding]; other site
1282356001335	Switch I region; other site
1282356001336	G2 box; other site
1282356001337	Switch II region; other site
1282356001338	G3 box; other site
1282356001339	G4 box; other site
1282356001340	G5 box; other site
1282356001341	KH domain; Region: KH_2; pfam07650
1282356001342	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
1282356001343	Recombination protein O N terminal; Region: RecO_N; pfam11967
1282356001344	Recombination protein O C terminal; Region: RecO_C; pfam02565
1282356001345	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
1282356001346	active site
1282356001347	hydrophilic channel; other site
1282356001348	dimerization interface [polypeptide binding]; other site
1282356001349	catalytic residues [active]
1282356001350	active site lid [active]
1282356001351	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
1282356001352	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1282356001353	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1282356001354	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1282356001355	nucleoside/Zn binding site; other site
1282356001356	dimer interface [polypeptide binding]; other site
1282356001357	catalytic motif [active]
1282356001358	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1282356001359	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356001360	S-adenosylmethionine binding site [chemical binding]; other site
1282356001361	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356001362	S-adenosylmethionine binding site [chemical binding]; other site
1282356001363	Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394
1282356001364	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
1282356001365	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356001366	Walker A motif; other site
1282356001367	ATP binding site [chemical binding]; other site
1282356001368	Walker B motif; other site
1282356001369	arginine finger; other site
1282356001370	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1282356001371	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1282356001372	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1282356001373	DNA-binding site [nucleotide binding]; DNA binding site
1282356001374	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1282356001375	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1282356001376	DNA-binding site [nucleotide binding]; DNA binding site
1282356001377	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1282356001378	hypothetical protein; Provisional; Region: PRK06102
1282356001379	Amidase; Region: Amidase; cl11426
1282356001380	Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938
1282356001381	active site
1282356001382	catalytic site [active]
1282356001383	Zn binding site [ion binding]; other site
1282356001384	tetramer interface [polypeptide binding]; other site
1282356001385	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1282356001386	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356001387	benzoate transport; Region: 2A0115; TIGR00895
1282356001388	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356001389	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1282356001390	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1282356001391	NAD(P) binding site [chemical binding]; other site
1282356001392	active site
1282356001393	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1282356001394	NAD(P) binding site [chemical binding]; other site
1282356001395	active site
1282356001396	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1282356001397	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1282356001398	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1282356001399	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1282356001400	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1282356001401	dimerization interface [polypeptide binding]; other site
1282356001402	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1282356001403	metal binding site [ion binding]; metal-binding site
1282356001404	active site
1282356001405	I-site; other site
1282356001406	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1282356001407	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1282356001408	dimerization interface [polypeptide binding]; other site
1282356001409	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1282356001410	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1282356001411	metal binding site [ion binding]; metal-binding site
1282356001412	active site
1282356001413	I-site; other site
1282356001414	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1282356001415	Protein of unknown function (DUF3034); Region: DUF3034; pfam11231
1282356001416	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
1282356001417	apolar tunnel; other site
1282356001418	heme binding site [chemical binding]; other site
1282356001419	dimerization interface [polypeptide binding]; other site
1282356001420	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
1282356001421	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
1282356001422	Trp docking motif [polypeptide binding]; other site
1282356001423	putative active site [active]
1282356001424	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
1282356001425	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1282356001426	N-terminal plug; other site
1282356001427	ligand-binding site [chemical binding]; other site
1282356001428	Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905
1282356001429	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
1282356001430	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
1282356001431	FAD binding pocket [chemical binding]; other site
1282356001432	FAD binding motif [chemical binding]; other site
1282356001433	phosphate binding motif [ion binding]; other site
1282356001434	NAD binding pocket [chemical binding]; other site
1282356001435	Predicted transcriptional regulators [Transcription]; Region: COG1695
1282356001436	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1282356001437	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1282356001438	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1282356001439	putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284
1282356001440	PapC N-terminal domain; Region: PapC_N; pfam13954
1282356001441	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
1282356001442	PapC C-terminal domain; Region: PapC_C; pfam13953
1282356001443	fimbrial chaperone protein StdC; Provisional; Region: PRK15254
1282356001444	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1282356001445	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
1282356001446	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1282356001447	Fimbrial protein; Region: Fimbrial; cl01416
1282356001448	Fimbrial protein; Region: Fimbrial; cl01416
1282356001449	Fimbrial protein; Region: Fimbrial; cl01416
1282356001450	Fimbrial protein; Region: Fimbrial; pfam00419
1282356001451	fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310
1282356001452	fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310
1282356001453	putative fimbrial protein TcfA; Provisional; Region: PRK15308
1282356001454	Leucine rich repeat; Region: LRR_8; pfam13855
1282356001455	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1282356001456	Transglycosylase; Region: Transgly; pfam00912
1282356001457	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1282356001458	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1282356001459	OpgC protein; Region: OpgC_C; pfam10129
1282356001460	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
1282356001461	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356001462	active site
1282356001463	phosphorylation site [posttranslational modification]
1282356001464	intermolecular recognition site; other site
1282356001465	dimerization interface [polypeptide binding]; other site
1282356001466	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1282356001467	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
1282356001468	nudix motif; other site
1282356001469	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1282356001470	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1282356001471	Coenzyme A binding pocket [chemical binding]; other site
1282356001472	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1282356001473	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
1282356001474	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356001475	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
1282356001476	putative dimerization interface [polypeptide binding]; other site
1282356001477	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1282356001478	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
1282356001479	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
1282356001480	catalytic residues [active]
1282356001481	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
1282356001482	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1282356001483	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1282356001484	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
1282356001485	inhibitor-cofactor binding pocket; inhibition site
1282356001486	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356001487	catalytic residue [active]
1282356001488	Esterase/lipase [General function prediction only]; Region: COG1647
1282356001489	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
1282356001490	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1282356001491	dimerization interface [polypeptide binding]; other site
1282356001492	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356001493	dimer interface [polypeptide binding]; other site
1282356001494	phosphorylation site [posttranslational modification]
1282356001495	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356001496	ATP binding site [chemical binding]; other site
1282356001497	Mg2+ binding site [ion binding]; other site
1282356001498	G-X-G motif; other site
1282356001499	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1282356001500	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356001501	active site
1282356001502	phosphorylation site [posttranslational modification]
1282356001503	intermolecular recognition site; other site
1282356001504	dimerization interface [polypeptide binding]; other site
1282356001505	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356001506	Walker A motif; other site
1282356001507	ATP binding site [chemical binding]; other site
1282356001508	Walker B motif; other site
1282356001509	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
1282356001510	arginine finger; other site
1282356001511	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1282356001512	GlpM protein; Region: GlpM; pfam06942
1282356001513	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1282356001514	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356001515	active site
1282356001516	phosphorylation site [posttranslational modification]
1282356001517	intermolecular recognition site; other site
1282356001518	dimerization interface [polypeptide binding]; other site
1282356001519	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356001520	Walker A motif; other site
1282356001521	ATP binding site [chemical binding]; other site
1282356001522	Walker B motif; other site
1282356001523	arginine finger; other site
1282356001524	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1282356001525	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
1282356001526	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356001527	dimer interface [polypeptide binding]; other site
1282356001528	phosphorylation site [posttranslational modification]
1282356001529	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356001530	ATP binding site [chemical binding]; other site
1282356001531	Mg2+ binding site [ion binding]; other site
1282356001532	G-X-G motif; other site
1282356001533	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1282356001534	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1282356001535	Walker A/P-loop; other site
1282356001536	ATP binding site [chemical binding]; other site
1282356001537	Q-loop/lid; other site
1282356001538	ABC transporter signature motif; other site
1282356001539	Walker B; other site
1282356001540	D-loop; other site
1282356001541	H-loop/switch region; other site
1282356001542	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1282356001543	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356001544	dimer interface [polypeptide binding]; other site
1282356001545	conserved gate region; other site
1282356001546	putative PBP binding loops; other site
1282356001547	ABC-ATPase subunit interface; other site
1282356001548	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356001549	dimer interface [polypeptide binding]; other site
1282356001550	conserved gate region; other site
1282356001551	putative PBP binding loops; other site
1282356001552	ABC-ATPase subunit interface; other site
1282356001553	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
1282356001554	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1282356001555	substrate binding pocket [chemical binding]; other site
1282356001556	membrane-bound complex binding site; other site
1282356001557	hinge residues; other site
1282356001558	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
1282356001559	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
1282356001560	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1282356001561	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1282356001562	glycerol kinase; Provisional; Region: glpK; PRK00047
1282356001563	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1282356001564	N- and C-terminal domain interface [polypeptide binding]; other site
1282356001565	active site
1282356001566	MgATP binding site [chemical binding]; other site
1282356001567	catalytic site [active]
1282356001568	metal binding site [ion binding]; metal-binding site
1282356001569	glycerol binding site [chemical binding]; other site
1282356001570	homotetramer interface [polypeptide binding]; other site
1282356001571	homodimer interface [polypeptide binding]; other site
1282356001572	protein IIAGlc interface [polypeptide binding]; other site
1282356001573	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
1282356001574	amphipathic channel; other site
1282356001575	Asn-Pro-Ala signature motifs; other site
1282356001576	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
1282356001577	putative deacylase active site [active]
1282356001578	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1282356001579	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
1282356001580	Walker A/P-loop; other site
1282356001581	ATP binding site [chemical binding]; other site
1282356001582	Q-loop/lid; other site
1282356001583	ABC transporter signature motif; other site
1282356001584	Walker B; other site
1282356001585	D-loop; other site
1282356001586	H-loop/switch region; other site
1282356001587	TOBE domain; Region: TOBE_2; pfam08402
1282356001588	ornithine carbamoyltransferase; Provisional; Region: PRK00779
1282356001589	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1282356001590	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1282356001591	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
1282356001592	The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762
1282356001593	putative [Fe4-S4] binding site [ion binding]; other site
1282356001594	putative molybdopterin cofactor binding site [chemical binding]; other site
1282356001595	The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782
1282356001596	putative molybdopterin cofactor binding site; other site
1282356001597	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
1282356001598	putative GSH binding site [chemical binding]; other site
1282356001599	catalytic residues [active]
1282356001600	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
1282356001601	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
1282356001602	heme binding site [chemical binding]; other site
1282356001603	ferroxidase pore; other site
1282356001604	ferroxidase diiron center [ion binding]; other site
1282356001605	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
1282356001606	peroxidase; Provisional; Region: PRK15000
1282356001607	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1282356001608	dimer interface [polypeptide binding]; other site
1282356001609	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1282356001610	catalytic triad [active]
1282356001611	peroxidatic and resolving cysteines [active]
1282356001612	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
1282356001613	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
1282356001614	dimer interface [polypeptide binding]; other site
1282356001615	catalytic site [active]
1282356001616	putative active site [active]
1282356001617	putative substrate binding site [chemical binding]; other site
1282356001618	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
1282356001619	active site
1282356001620	substrate binding pocket [chemical binding]; other site
1282356001621	dimer interface [polypeptide binding]; other site
1282356001622	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1282356001623	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1282356001624	ligand binding site [chemical binding]; other site
1282356001625	argininosuccinate synthase; Provisional; Region: PRK13820
1282356001626	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1282356001627	ANP binding site [chemical binding]; other site
1282356001628	Substrate Binding Site II [chemical binding]; other site
1282356001629	Substrate Binding Site I [chemical binding]; other site
1282356001630	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1282356001631	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356001632	active site
1282356001633	phosphorylation site [posttranslational modification]
1282356001634	intermolecular recognition site; other site
1282356001635	dimerization interface [polypeptide binding]; other site
1282356001636	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1282356001637	DNA binding residues [nucleotide binding]
1282356001638	dimerization interface [polypeptide binding]; other site
1282356001639	endonuclease III; Provisional; Region: PRK10702
1282356001640	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1282356001641	minor groove reading motif; other site
1282356001642	helix-hairpin-helix signature motif; other site
1282356001643	substrate binding pocket [chemical binding]; other site
1282356001644	active site
1282356001645	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
1282356001646	ferredoxin; Provisional; Region: PRK08764
1282356001647	Putative Fe-S cluster; Region: FeS; pfam04060
1282356001648	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
1282356001649	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
1282356001650	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1282356001651	active site
1282356001652	HIGH motif; other site
1282356001653	KMSKS motif; other site
1282356001654	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1282356001655	tRNA binding surface [nucleotide binding]; other site
1282356001656	anticodon binding site; other site
1282356001657	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
1282356001658	dimer interface [polypeptide binding]; other site
1282356001659	putative tRNA-binding site [nucleotide binding]; other site
1282356001660	antiporter inner membrane protein; Provisional; Region: PRK11670
1282356001661	Domain of unknown function DUF59; Region: DUF59; pfam01883
1282356001662	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1282356001663	Walker A motif; other site
1282356001664	Ferredoxin [Energy production and conversion]; Region: COG1146
1282356001665	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
1282356001666	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
1282356001667	MutS domain I; Region: MutS_I; pfam01624
1282356001668	MutS domain II; Region: MutS_II; pfam05188
1282356001669	MutS domain III; Region: MutS_III; pfam05192
1282356001670	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
1282356001671	Walker A/P-loop; other site
1282356001672	ATP binding site [chemical binding]; other site
1282356001673	Q-loop/lid; other site
1282356001674	ABC transporter signature motif; other site
1282356001675	Walker B; other site
1282356001676	D-loop; other site
1282356001677	H-loop/switch region; other site
1282356001678	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
1282356001679	CGNR zinc finger; Region: zf-CGNR; pfam11706
1282356001680	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1282356001681	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1282356001682	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1282356001683	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1282356001684	non-specific DNA binding site [nucleotide binding]; other site
1282356001685	salt bridge; other site
1282356001686	sequence-specific DNA binding site [nucleotide binding]; other site
1282356001687	Predicted transcriptional regulator [Transcription]; Region: COG2932
1282356001688	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1282356001689	Catalytic site [active]
1282356001690	Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812
1282356001691	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
1282356001692	Baseplate J-like protein; Region: Baseplate_J; cl01294
1282356001693	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684
1282356001694	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
1282356001695	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
1282356001696	Phage tail tube protein FII; Region: Phage_tube; cl01390
1282356001697	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
1282356001698	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
1282356001699	large tegument protein UL36; Provisional; Region: PHA03247
1282356001700	Phage P2 GpU; Region: Phage_P2_GpU; cl01391
1282356001701	Phage Tail Protein X; Region: Phage_tail_X; cl02088
1282356001702	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
1282356001703	Predicted chitinase [General function prediction only]; Region: COG3179
1282356001704	catalytic residue [active]
1282356001705	Bacteriophage lysis protein; Region: Phage_lysis; pfam03245
1282356001706	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
1282356001707	recombinase A; Provisional; Region: recA; PRK09354
1282356001708	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1282356001709	hexamer interface [polypeptide binding]; other site
1282356001710	Walker A motif; other site
1282356001711	ATP binding site [chemical binding]; other site
1282356001712	Walker B motif; other site
1282356001713	recombination regulator RecX; Reviewed; Region: recX; PRK00117
1282356001714	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
1282356001715	Domain of unknown function (DUF4146); Region: DUF4146; pfam13652
1282356001716	DTW domain; Region: DTW; cl01221
1282356001717	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1282356001718	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356001719	active site
1282356001720	phosphorylation site [posttranslational modification]
1282356001721	intermolecular recognition site; other site
1282356001722	dimerization interface [polypeptide binding]; other site
1282356001723	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1282356001724	DNA binding residues [nucleotide binding]
1282356001725	dimerization interface [polypeptide binding]; other site
1282356001726	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
1282356001727	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
1282356001728	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356001729	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
1282356001730	putative dimerization interface [polypeptide binding]; other site
1282356001731	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1282356001732	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
1282356001733	FAD binding pocket [chemical binding]; other site
1282356001734	FAD binding motif [chemical binding]; other site
1282356001735	phosphate binding motif [ion binding]; other site
1282356001736	beta-alpha-beta structure motif; other site
1282356001737	NAD binding pocket [chemical binding]; other site
1282356001738	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
1282356001739	homodimer interaction site [polypeptide binding]; other site
1282356001740	cofactor binding site; other site
1282356001741	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
1282356001742	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
1282356001743	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
1282356001744	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1282356001745	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1282356001746	RNA binding surface [nucleotide binding]; other site
1282356001747	Pseudouridine synthase, a subgroup of the RsuA family; Region: PSSA_1; cd02555
1282356001748	active site
1282356001749	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1282356001750	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1282356001751	Coenzyme A binding pocket [chemical binding]; other site
1282356001752	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
1282356001753	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1282356001754	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1282356001755	FeS/SAM binding site; other site
1282356001756	TRAM domain; Region: TRAM; cl01282
1282356001757	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
1282356001758	potassium uptake protein; Region: kup; TIGR00794
1282356001759	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1282356001760	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
1282356001761	active site
1282356001762	FMN binding site [chemical binding]; other site
1282356001763	substrate binding site [chemical binding]; other site
1282356001764	homotetramer interface [polypeptide binding]; other site
1282356001765	catalytic residue [active]
1282356001766	Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131
1282356001767	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
1282356001768	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979
1282356001769	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
1282356001770	putative metal binding site [ion binding]; other site
1282356001771	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1282356001772	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1282356001773	dimerization interface [polypeptide binding]; other site
1282356001774	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356001775	dimer interface [polypeptide binding]; other site
1282356001776	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
1282356001777	putative CheW interface [polypeptide binding]; other site
1282356001778	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
1282356001779	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
1282356001780	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
1282356001781	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1282356001782	binding surface
1282356001783	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1282356001784	TPR motif; other site
1282356001785	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
1282356001786	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1282356001787	putative binding surface; other site
1282356001788	active site
1282356001789	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
1282356001790	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356001791	ATP binding site [chemical binding]; other site
1282356001792	Mg2+ binding site [ion binding]; other site
1282356001793	G-X-G motif; other site
1282356001794	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
1282356001795	Response regulator receiver domain; Region: Response_reg; pfam00072
1282356001796	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356001797	active site
1282356001798	phosphorylation site [posttranslational modification]
1282356001799	intermolecular recognition site; other site
1282356001800	dimerization interface [polypeptide binding]; other site
1282356001801	chemotaxis-specific methylesterase; Provisional; Region: PRK12555
1282356001802	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356001803	active site
1282356001804	phosphorylation site [posttranslational modification]
1282356001805	intermolecular recognition site; other site
1282356001806	CheB methylesterase; Region: CheB_methylest; pfam01339
1282356001807	Response regulator receiver domain; Region: Response_reg; pfam00072
1282356001808	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356001809	active site
1282356001810	phosphorylation site [posttranslational modification]
1282356001811	intermolecular recognition site; other site
1282356001812	dimerization interface [polypeptide binding]; other site
1282356001813	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1282356001814	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1282356001815	metal binding site [ion binding]; metal-binding site
1282356001816	active site
1282356001817	I-site; other site
1282356001818	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1282356001819	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
1282356001820	RF-1 domain; Region: RF-1; pfam00472
1282356001821	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1282356001822	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1282356001823	dimer interface [polypeptide binding]; other site
1282356001824	putative anticodon binding site; other site
1282356001825	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1282356001826	motif 1; other site
1282356001827	active site
1282356001828	motif 2; other site
1282356001829	motif 3; other site
1282356001830	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
1282356001831	Domain of unknown function (DUF1704); Region: DUF1704; cl06858
1282356001832	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1282356001833	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1282356001834	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1282356001835	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1282356001836	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1282356001837	ligand binding site [chemical binding]; other site
1282356001838	Domain of unknown function (DUF4398); Region: DUF4398; pfam14346
1282356001839	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
1282356001840	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
1282356001841	adenylate kinase; Reviewed; Region: adk; PRK00279
1282356001842	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1282356001843	AMP-binding site [chemical binding]; other site
1282356001844	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1282356001845	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1282356001846	Glycoprotease family; Region: Peptidase_M22; pfam00814
1282356001847	Protein of unknown function DUF72; Region: DUF72; cl00777
1282356001848	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1282356001849	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1282356001850	tetramer interface [polypeptide binding]; other site
1282356001851	active site
1282356001852	Mg2+/Mn2+ binding site [ion binding]; other site
1282356001853	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
1282356001854	Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517
1282356001855	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1282356001856	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1282356001857	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
1282356001858	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1282356001859	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1282356001860	HlyD family secretion protein; Region: HlyD_3; pfam13437
1282356001861	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1282356001862	Protein of unknown function (DUF4197); Region: DUF4197; pfam13852
1282356001863	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
1282356001864	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
1282356001865	putative acyl-acceptor binding pocket; other site
1282356001866	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
1282356001867	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356001868	S-adenosylmethionine binding site [chemical binding]; other site
1282356001869	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
1282356001870	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
1282356001871	metal binding site [ion binding]; metal-binding site
1282356001872	dimer interface [polypeptide binding]; other site
1282356001873	Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309
1282356001874	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1282356001875	NdvC_like  proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase; Region: CESA_NdvC_like; cd06435
1282356001876	Ligand binding site; other site
1282356001877	DXD motif; other site
1282356001878	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
1282356001879	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
1282356001880	putative ATP binding site [chemical binding]; other site
1282356001881	putative substrate interface [chemical binding]; other site
1282356001882	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
1282356001883	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1282356001884	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1282356001885	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1282356001886	catalytic residue [active]
1282356001887	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536
1282356001888	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
1282356001889	putative trimer interface [polypeptide binding]; other site
1282356001890	putative CoA binding site [chemical binding]; other site
1282356001891	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
1282356001892	ArsC family; Region: ArsC; pfam03960
1282356001893	putative catalytic residues [active]
1282356001894	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
1282356001895	Astacin (Peptidase family M12A); Region: Astacin; pfam01400
1282356001896	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
1282356001897	active site
1282356001898	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
1282356001899	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1282356001900	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356001901	homodimer interface [polypeptide binding]; other site
1282356001902	catalytic residue [active]
1282356001903	PII uridylyl-transferase; Provisional; Region: glnD; PRK00275
1282356001904	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1282356001905	metal binding triad; other site
1282356001906	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1282356001907	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1282356001908	Zn2+ binding site [ion binding]; other site
1282356001909	Mg2+ binding site [ion binding]; other site
1282356001910	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
1282356001911	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
1282356001912	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1282356001913	active site
1282356001914	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1282356001915	rRNA interaction site [nucleotide binding]; other site
1282356001916	S8 interaction site; other site
1282356001917	putative laminin-1 binding site; other site
1282356001918	elongation factor Ts; Provisional; Region: tsf; PRK09377
1282356001919	UBA/TS-N domain; Region: UBA; pfam00627
1282356001920	Elongation factor TS; Region: EF_TS; pfam00889
1282356001921	Elongation factor TS; Region: EF_TS; pfam00889
1282356001922	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1282356001923	putative nucleotide binding site [chemical binding]; other site
1282356001924	uridine monophosphate binding site [chemical binding]; other site
1282356001925	homohexameric interface [polypeptide binding]; other site
1282356001926	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1282356001927	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1282356001928	hinge region; other site
1282356001929	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1282356001930	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
1282356001931	catalytic residue [active]
1282356001932	putative FPP diphosphate  binding site; other site
1282356001933	putative FPP binding hydrophobic cleft; other site
1282356001934	dimer interface [polypeptide binding]; other site
1282356001935	putative IPP diphosphate binding site; other site
1282356001936	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
1282356001937	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1282356001938	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
1282356001939	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1282356001940	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
1282356001941	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
1282356001942	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1282356001943	zinc metallopeptidase RseP; Provisional; Region: PRK10779
1282356001944	active site
1282356001945	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1282356001946	protein binding site [polypeptide binding]; other site
1282356001947	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1282356001948	protein binding site [polypeptide binding]; other site
1282356001949	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1282356001950	putative substrate binding region [chemical binding]; other site
1282356001951	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
1282356001952	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1282356001953	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1282356001954	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1282356001955	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1282356001956	Surface antigen; Region: Bac_surface_Ag; pfam01103
1282356001957	periplasmic chaperone; Provisional; Region: PRK10780
1282356001958	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
1282356001959	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
1282356001960	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
1282356001961	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
1282356001962	trimer interface [polypeptide binding]; other site
1282356001963	active site
1282356001964	UDP-GlcNAc binding site [chemical binding]; other site
1282356001965	lipid binding site [chemical binding]; lipid-binding site
1282356001966	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1282356001967	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
1282356001968	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
1282356001969	active site
1282356001970	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
1282356001971	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
1282356001972	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1282356001973	RNA/DNA hybrid binding site [nucleotide binding]; other site
1282356001974	active site
1282356001975	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
1282356001976	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
1282356001977	putative active site [active]
1282356001978	putative PHP Thumb interface [polypeptide binding]; other site
1282356001979	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1282356001980	generic binding surface II; other site
1282356001981	generic binding surface I; other site
1282356001982	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
1282356001983	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
1282356001984	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1282356001985	TilS substrate binding domain; Region: TilS; pfam09179
1282356001986	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
1282356001987	CTP synthetase; Validated; Region: pyrG; PRK05380
1282356001988	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1282356001989	Catalytic site [active]
1282356001990	active site
1282356001991	UTP binding site [chemical binding]; other site
1282356001992	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1282356001993	active site
1282356001994	putative oxyanion hole; other site
1282356001995	catalytic triad [active]
1282356001996	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
1282356001997	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1282356001998	enolase; Provisional; Region: eno; PRK00077
1282356001999	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1282356002000	dimer interface [polypeptide binding]; other site
1282356002001	metal binding site [ion binding]; metal-binding site
1282356002002	substrate binding pocket [chemical binding]; other site
1282356002003	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
1282356002004	Septum formation initiator; Region: DivIC; cl17659
1282356002005	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1282356002006	substrate binding site; other site
1282356002007	dimer interface; other site
1282356002008	LysR family transcriptional regulator; Provisional; Region: PRK14997
1282356002009	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356002010	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like_1; cd08470
1282356002011	putative effector binding pocket; other site
1282356002012	putative dimerization interface [polypeptide binding]; other site
1282356002013	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
1282356002014	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
1282356002015	substrate binding site [chemical binding]; other site
1282356002016	catalytic Zn binding site [ion binding]; other site
1282356002017	NAD binding site [chemical binding]; other site
1282356002018	structural Zn binding site [ion binding]; other site
1282356002019	dimer interface [polypeptide binding]; other site
1282356002020	S-formylglutathione hydrolase; Region: PLN02442
1282356002021	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
1282356002022	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
1282356002023	homotrimer interaction site [polypeptide binding]; other site
1282356002024	zinc binding site [ion binding]; other site
1282356002025	CDP-binding sites; other site
1282356002026	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
1282356002027	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
1282356002028	Permutation of conserved domain; other site
1282356002029	active site
1282356002030	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
1282356002031	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
1282356002032	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
1282356002033	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356002034	S-adenosylmethionine binding site [chemical binding]; other site
1282356002035	Peptidase family M23; Region: Peptidase_M23; pfam01551
1282356002036	RNA polymerase sigma factor RpoS; Validated; Region: PRK05657
1282356002037	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1282356002038	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1282356002039	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1282356002040	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1282356002041	DNA binding residues [nucleotide binding]
1282356002042	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1282356002043	DNA-binding site [nucleotide binding]; DNA binding site
1282356002044	RNA-binding motif; other site
1282356002045	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1282356002046	trimer interface [polypeptide binding]; other site
1282356002047	active site
1282356002048	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
1282356002049	putative active site [active]
1282356002050	putative metal binding site [ion binding]; other site
1282356002051	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
1282356002052	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1282356002053	ATP binding site [chemical binding]; other site
1282356002054	putative Mg++ binding site [ion binding]; other site
1282356002055	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1282356002056	nucleotide binding region [chemical binding]; other site
1282356002057	ATP-binding site [chemical binding]; other site
1282356002058	DEAD/H associated; Region: DEAD_assoc; pfam08494
1282356002059	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
1282356002060	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1282356002061	Walker A/P-loop; other site
1282356002062	ATP binding site [chemical binding]; other site
1282356002063	Q-loop/lid; other site
1282356002064	ABC transporter signature motif; other site
1282356002065	Walker B; other site
1282356002066	D-loop; other site
1282356002067	H-loop/switch region; other site
1282356002068	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
1282356002069	active site
1282356002070	Zn binding site [ion binding]; other site
1282356002071	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1282356002072	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356002073	dimer interface [polypeptide binding]; other site
1282356002074	conserved gate region; other site
1282356002075	putative PBP binding loops; other site
1282356002076	ABC-ATPase subunit interface; other site
1282356002077	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1282356002078	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356002079	dimer interface [polypeptide binding]; other site
1282356002080	conserved gate region; other site
1282356002081	putative PBP binding loops; other site
1282356002082	ABC-ATPase subunit interface; other site
1282356002083	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
1282356002084	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1282356002085	substrate binding pocket [chemical binding]; other site
1282356002086	membrane-bound complex binding site; other site
1282356002087	hinge residues; other site
1282356002088	ATP-dependent DNA ligase; Validated; Region: PRK09247
1282356002089	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
1282356002090	active site
1282356002091	DNA binding site [nucleotide binding]
1282356002092	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
1282356002093	DNA binding site [nucleotide binding]
1282356002094	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
1282356002095	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1282356002096	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
1282356002097	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
1282356002098	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
1282356002099	active site
1282356002100	SEC-C motif; Region: SEC-C; pfam02810
1282356002101	LEA14-like dessication related protein [Defense mechanisms]; Region: COG5608
1282356002102	Late embryogenesis abundant protein; Region: LEA_2; pfam03168
1282356002103	hypothetical protein; Provisional; Region: PRK00183
1282356002104	SEC-C motif; Region: SEC-C; pfam02810
1282356002105	Predicted integral membrane protein [Function unknown]; Region: COG5615
1282356002106	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
1282356002107	DEAD/DEAH box helicase; Region: DEAD; pfam00270
1282356002108	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1282356002109	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
1282356002110	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1282356002111	Beta-lactamase; Region: Beta-lactamase; pfam00144
1282356002112	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1282356002113	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1282356002114	ligand binding site [chemical binding]; other site
1282356002115	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
1282356002116	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1282356002117	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
1282356002118	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
1282356002119	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560
1282356002120	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1282356002121	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
1282356002122	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1282356002123	catalytic residue [active]
1282356002124	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
1282356002125	Predicted membrane protein [Function unknown]; Region: COG3650
1282356002126	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
1282356002127	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063
1282356002128	putative NAD(P) binding site [chemical binding]; other site
1282356002129	homodimer interface [polypeptide binding]; other site
1282356002130	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356002131	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356002132	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1282356002133	putative effector binding pocket; other site
1282356002134	dimerization interface [polypeptide binding]; other site
1282356002135	Predicted membrane protein [Function unknown]; Region: COG2259
1282356002136	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
1282356002137	hypothetical protein; Provisional; Region: PRK05409
1282356002138	Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048
1282356002139	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1282356002140	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1282356002141	Walker A/P-loop; other site
1282356002142	ATP binding site [chemical binding]; other site
1282356002143	Q-loop/lid; other site
1282356002144	ABC transporter signature motif; other site
1282356002145	Walker B; other site
1282356002146	D-loop; other site
1282356002147	H-loop/switch region; other site
1282356002148	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
1282356002149	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1282356002150	Walker A/P-loop; other site
1282356002151	ATP binding site [chemical binding]; other site
1282356002152	Q-loop/lid; other site
1282356002153	ABC transporter signature motif; other site
1282356002154	Walker B; other site
1282356002155	D-loop; other site
1282356002156	H-loop/switch region; other site
1282356002157	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
1282356002158	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
1282356002159	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1282356002160	TM-ABC transporter signature motif; other site
1282356002161	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1282356002162	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1282356002163	TM-ABC transporter signature motif; other site
1282356002164	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1282356002165	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1282356002166	dimerization interface [polypeptide binding]; other site
1282356002167	ligand binding site [chemical binding]; other site
1282356002168	Protein of unknown function (DUF2288); Region: DUF2288; pfam10052
1282356002169	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
1282356002170	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
1282356002171	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
1282356002172	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
1282356002173	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1282356002174	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1282356002175	metal binding site [ion binding]; metal-binding site
1282356002176	active site
1282356002177	I-site; other site
1282356002178	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1282356002179	Flagellin N-methylase; Region: FliB; cl00497
1282356002180	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356002181	putative substrate translocation pore; other site
1282356002182	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1282356002183	ATP-dependent helicase HepA; Validated; Region: PRK04914
1282356002184	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1282356002185	ATP binding site [chemical binding]; other site
1282356002186	putative Mg++ binding site [ion binding]; other site
1282356002187	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1282356002188	nucleotide binding region [chemical binding]; other site
1282356002189	ATP-binding site [chemical binding]; other site
1282356002190	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1282356002191	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1282356002192	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
1282356002193	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1282356002194	Bacterial transcriptional regulator; Region: IclR; pfam01614
1282356002195	benzoate transport; Region: 2A0115; TIGR00895
1282356002196	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356002197	putative substrate translocation pore; other site
1282356002198	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356002199	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
1282356002200	Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057
1282356002201	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
1282356002202	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1282356002203	dimer interface [polypeptide binding]; other site
1282356002204	active site
1282356002205	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
1282356002206	Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464
1282356002207	heterodimer interface [polypeptide binding]; other site
1282356002208	multimer interface [polypeptide binding]; other site
1282356002209	active site
1282356002210	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
1282356002211	heterodimer interface [polypeptide binding]; other site
1282356002212	active site
1282356002213	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
1282356002214	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356002215	putative substrate translocation pore; other site
1282356002216	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053
1282356002217	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
1282356002218	tetramer interface [polypeptide binding]; other site
1282356002219	active site
1282356002220	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
1282356002221	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1282356002222	4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425
1282356002223	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
1282356002224	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1282356002225	NodB motif; other site
1282356002226	active site
1282356002227	catalytic site [active]
1282356002228	metal binding site [ion binding]; metal-binding site
1282356002229	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
1282356002230	outer membrane porin, OprD family; Region: OprD; pfam03573
1282356002231	DnaJ domain; Region: DnaJ; pfam00226
1282356002232	HSP70 interaction site [polypeptide binding]; other site
1282356002233	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
1282356002234	Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235
1282356002235	nucleotide binding site [chemical binding]; other site
1282356002236	putative NEF/HSP70 interaction site [polypeptide binding]; other site
1282356002237	SBD interface [polypeptide binding]; other site
1282356002238	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1282356002239	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
1282356002240	Protein export membrane protein; Region: SecD_SecF; cl14618
1282356002241	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
1282356002242	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1282356002243	HlyD family secretion protein; Region: HlyD_3; pfam13437
1282356002244	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
1282356002245	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1282356002246	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
1282356002247	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1282356002248	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
1282356002249	FMN binding site [chemical binding]; other site
1282356002250	active site
1282356002251	substrate binding site [chemical binding]; other site
1282356002252	catalytic residue [active]
1282356002253	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356002254	putative substrate translocation pore; other site
1282356002255	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1282356002256	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1282356002257	dimerization interface [polypeptide binding]; other site
1282356002258	putative DNA binding site [nucleotide binding]; other site
1282356002259	putative Zn2+ binding site [ion binding]; other site
1282356002260	Protein of unknown function, DUF479; Region: DUF479; cl01203
1282356002261	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1282356002262	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1282356002263	putative acyl-acceptor binding pocket; other site
1282356002264	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
1282356002265	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1282356002266	Beta-lactamase; Region: Beta-lactamase; pfam00144
1282356002267	YceI-like domain; Region: YceI; pfam04264
1282356002268	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1282356002269	PLD-like domain; Region: PLDc_2; pfam13091
1282356002270	putative active site [active]
1282356002271	catalytic site [active]
1282356002272	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
1282356002273	PLD-like domain; Region: PLDc_2; pfam13091
1282356002274	putative active site [active]
1282356002275	catalytic site [active]
1282356002276	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
1282356002277	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
1282356002278	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
1282356002279	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
1282356002280	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
1282356002281	Repair protein; Region: Repair_PSII; pfam04536
1282356002282	Repair protein; Region: Repair_PSII; cl01535
1282356002283	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1282356002284	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356002285	S-adenosylmethionine binding site [chemical binding]; other site
1282356002286	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
1282356002287	FecR protein; Region: FecR; pfam04773
1282356002288	putative alcohol dehydrogenase; Provisional; Region: PRK09860
1282356002289	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
1282356002290	dimer interface [polypeptide binding]; other site
1282356002291	active site
1282356002292	metal binding site [ion binding]; metal-binding site
1282356002293	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356002294	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
1282356002295	putative substrate translocation pore; other site
1282356002296	Protein of unknown function, DUF606; Region: DUF606; pfam04657
1282356002297	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356002298	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356002299	The C-terminal substrate binding domain of LysR-type transcriptional regulator ToxR regulates the expression of the toxoflavin biosynthesis genes; contains the type 2 periplasmic bindinig fold; Region: PBP2_ToxR; cd08465
1282356002300	putative substrate binding pocket [chemical binding]; other site
1282356002301	putative dimerization interface [polypeptide binding]; other site
1282356002302	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
1282356002303	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1282356002304	active site
1282356002305	metal binding site [ion binding]; metal-binding site
1282356002306	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1282356002307	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
1282356002308	Low affinity iron permease; Region: Iron_permease; pfam04120
1282356002309	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1282356002310	Coenzyme A binding pocket [chemical binding]; other site
1282356002311	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1282356002312	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1282356002313	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1282356002314	DNA binding site [nucleotide binding]
1282356002315	active site
1282356002316	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
1282356002317	YcfA-like protein; Region: YcfA; pfam07927
1282356002318	Protein of unknown function (DUF3833); Region: DUF3833; pfam12915
1282356002319	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1282356002320	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
1282356002321	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
1282356002322	active site
1282356002323	uracil binding [chemical binding]; other site
1282356002324	Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375
1282356002325	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1282356002326	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1282356002327	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1282356002328	dimerization interface [polypeptide binding]; other site
1282356002329	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356002330	dimer interface [polypeptide binding]; other site
1282356002331	putative CheW interface [polypeptide binding]; other site
1282356002332	Protein of unknown function (DUF3757); Region: DUF3757; pfam12582
1282356002333	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
1282356002334	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1282356002335	substrate binding site [chemical binding]; other site
1282356002336	oxyanion hole (OAH) forming residues; other site
1282356002337	trimer interface [polypeptide binding]; other site
1282356002338	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
1282356002339	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1282356002340	ligand binding site [chemical binding]; other site
1282356002341	active site
1282356002342	UGI interface [polypeptide binding]; other site
1282356002343	catalytic site [active]
1282356002344	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
1282356002345	Putative ammonia monooxygenase; Region: AmoA; pfam05145
1282356002346	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
1282356002347	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
1282356002348	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
1282356002349	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
1282356002350	outer membrane porin, OprD family; Region: OprD; pfam03573
1282356002351	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
1282356002352	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356002353	active site
1282356002354	phosphorylation site [posttranslational modification]
1282356002355	intermolecular recognition site; other site
1282356002356	dimerization interface [polypeptide binding]; other site
1282356002357	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1282356002358	DNA binding site [nucleotide binding]
1282356002359	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
1282356002360	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1282356002361	HAMP domain; Region: HAMP; pfam00672
1282356002362	dimerization interface [polypeptide binding]; other site
1282356002363	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356002364	dimer interface [polypeptide binding]; other site
1282356002365	phosphorylation site [posttranslational modification]
1282356002366	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356002367	ATP binding site [chemical binding]; other site
1282356002368	Mg2+ binding site [ion binding]; other site
1282356002369	G-X-G motif; other site
1282356002370	HDOD domain; Region: HDOD; pfam08668
1282356002371	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
1282356002372	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
1282356002373	Uncharacterized conserved protein [Function unknown]; Region: COG2938
1282356002374	L-aspartate oxidase; Provisional; Region: PRK09077
1282356002375	L-aspartate oxidase; Provisional; Region: PRK06175
1282356002376	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1282356002377	RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923
1282356002378	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1282356002379	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1282356002380	DNA binding residues [nucleotide binding]
1282356002381	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073
1282356002382	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
1282356002383	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
1282356002384	anti-sigma E factor; Provisional; Region: rseB; PRK09455
1282356002385	MucB/RseB family; Region: MucB_RseB; pfam03888
1282356002386	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
1282356002387	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1282356002388	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1282356002389	protein binding site [polypeptide binding]; other site
1282356002390	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1282356002391	protein binding site [polypeptide binding]; other site
1282356002392	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
1282356002393	Peptidase family M48; Region: Peptidase_M48; cl12018
1282356002394	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
1282356002395	CPxP  motif; other site
1282356002396	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1282356002397	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1282356002398	catalytic triad [active]
1282356002399	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
1282356002400	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1282356002401	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869
1282356002402	dihydrodipicolinate synthase; Region: dapA; TIGR00674
1282356002403	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1282356002404	dimer interface [polypeptide binding]; other site
1282356002405	active site
1282356002406	catalytic residue [active]
1282356002407	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
1282356002408	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
1282356002409	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
1282356002410	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
1282356002411	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
1282356002412	ATP binding site [chemical binding]; other site
1282356002413	active site
1282356002414	substrate binding site [chemical binding]; other site
1282356002415	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1282356002416	putative trimer interface [polypeptide binding]; other site
1282356002417	putative CoA binding site [chemical binding]; other site
1282356002418	ribonucleoside transporter; Reviewed; Region: nepI; PRK10213
1282356002419	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356002420	putative substrate translocation pore; other site
1282356002421	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1282356002422	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1282356002423	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1282356002424	dimerization interface [polypeptide binding]; other site
1282356002425	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356002426	dimer interface [polypeptide binding]; other site
1282356002427	putative CheW interface [polypeptide binding]; other site
1282356002428	Response regulator receiver domain; Region: Response_reg; pfam00072
1282356002429	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356002430	active site
1282356002431	phosphorylation site [posttranslational modification]
1282356002432	intermolecular recognition site; other site
1282356002433	dimerization interface [polypeptide binding]; other site
1282356002434	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1282356002435	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
1282356002436	dimer interface [polypeptide binding]; other site
1282356002437	phosphorylation site [posttranslational modification]
1282356002438	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356002439	ATP binding site [chemical binding]; other site
1282356002440	Mg2+ binding site [ion binding]; other site
1282356002441	G-X-G motif; other site
1282356002442	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1282356002443	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356002444	active site
1282356002445	phosphorylation site [posttranslational modification]
1282356002446	intermolecular recognition site; other site
1282356002447	dimerization interface [polypeptide binding]; other site
1282356002448	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356002449	dimer interface [polypeptide binding]; other site
1282356002450	phosphorylation site [posttranslational modification]
1282356002451	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356002452	ATP binding site [chemical binding]; other site
1282356002453	Mg2+ binding site [ion binding]; other site
1282356002454	G-X-G motif; other site
1282356002455	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
1282356002456	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1282356002457	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
1282356002458	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
1282356002459	ATP binding site [chemical binding]; other site
1282356002460	Mg2+ binding site [ion binding]; other site
1282356002461	G-X-G motif; other site
1282356002462	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
1282356002463	RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361
1282356002464	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
1282356002465	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356002466	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356002467	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
1282356002468	putative dimerization interface [polypeptide binding]; other site
1282356002469	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1282356002470	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1282356002471	citrate-proton symporter; Provisional; Region: PRK15075
1282356002472	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356002473	putative substrate translocation pore; other site
1282356002474	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356002475	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356002476	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464
1282356002477	putative substrate binding pocket [chemical binding]; other site
1282356002478	putative dimerization interface [polypeptide binding]; other site
1282356002479	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356002480	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356002481	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
1282356002482	substrate binding pocket [chemical binding]; other site
1282356002483	dimerization interface [polypeptide binding]; other site
1282356002484	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
1282356002485	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356002486	putative substrate translocation pore; other site
1282356002487	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
1282356002488	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1282356002489	NAD binding site [chemical binding]; other site
1282356002490	putative active site [active]
1282356002491	substrate binding site [chemical binding]; other site
1282356002492	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1282356002493	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356002494	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356002495	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1282356002496	putative effector binding pocket; other site
1282356002497	dimerization interface [polypeptide binding]; other site
1282356002498	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
1282356002499	Cupin domain; Region: Cupin_2; pfam07883
1282356002500	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1282356002501	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
1282356002502	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1282356002503	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1282356002504	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356002505	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1282356002506	putative substrate translocation pore; other site
1282356002507	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356002508	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
1282356002509	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1282356002510	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1282356002511	substrate binding pocket [chemical binding]; other site
1282356002512	membrane-bound complex binding site; other site
1282356002513	hinge residues; other site
1282356002514	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356002515	S-adenosylmethionine binding site [chemical binding]; other site
1282356002516	ribonuclease D; Region: rnd; TIGR01388
1282356002517	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
1282356002518	catalytic site [active]
1282356002519	putative active site [active]
1282356002520	putative substrate binding site [chemical binding]; other site
1282356002521	HRDC domain; Region: HRDC; pfam00570
1282356002522	YcgL domain; Region: YcgL; pfam05166
1282356002523	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
1282356002524	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1282356002525	NAD binding site [chemical binding]; other site
1282356002526	ligand binding site [chemical binding]; other site
1282356002527	catalytic site [active]
1282356002528	hypothetical protein; Provisional; Region: PRK05170
1282356002529	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
1282356002530	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
1282356002531	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1282356002532	active site
1282356002533	Putative ParB-like nuclease; Region: ParBc_2; cl17538
1282356002534	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1282356002535	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
1282356002536	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1282356002537	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
1282356002538	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
1282356002539	putative active site [active]
1282356002540	putative dimer interface [polypeptide binding]; other site
1282356002541	Protein of unknown function (DUF2937); Region: DUF2937; pfam11157
1282356002542	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
1282356002543	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1282356002544	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356002545	Walker A motif; other site
1282356002546	ATP binding site [chemical binding]; other site
1282356002547	Walker B motif; other site
1282356002548	arginine finger; other site
1282356002549	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
1282356002550	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1282356002551	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1282356002552	dimer interface [polypeptide binding]; other site
1282356002553	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356002554	catalytic residue [active]
1282356002555	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
1282356002556	aconitate hydratase; Validated; Region: PRK09277
1282356002557	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
1282356002558	substrate binding site [chemical binding]; other site
1282356002559	ligand binding site [chemical binding]; other site
1282356002560	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
1282356002561	substrate binding site [chemical binding]; other site
1282356002562	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
1282356002563	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
1282356002564	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
1282356002565	CPxP  motif; other site
1282356002566	multidrug efflux protein; Reviewed; Region: PRK01766
1282356002567	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
1282356002568	cation binding site [ion binding]; other site
1282356002569	erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257
1282356002570	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
1282356002571	ligand binding site [chemical binding]; other site
1282356002572	NAD binding site [chemical binding]; other site
1282356002573	catalytic site [active]
1282356002574	homodimer interface [polypeptide binding]; other site
1282356002575	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
1282356002576	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1282356002577	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1282356002578	Walker A/P-loop; other site
1282356002579	ATP binding site [chemical binding]; other site
1282356002580	Q-loop/lid; other site
1282356002581	ABC transporter signature motif; other site
1282356002582	Walker B; other site
1282356002583	D-loop; other site
1282356002584	H-loop/switch region; other site
1282356002585	lytic murein transglycosylase; Provisional; Region: PRK11619
1282356002586	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1282356002587	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1282356002588	catalytic residue [active]
1282356002589	ABC transporter ATPase component; Reviewed; Region: PRK11147
1282356002590	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1282356002591	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1282356002592	ABC transporter; Region: ABC_tran_2; pfam12848
1282356002593	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1282356002594	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1282356002595	Ligand Binding Site [chemical binding]; other site
1282356002596	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
1282356002597	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1282356002598	substrate binding site [chemical binding]; other site
1282356002599	oxyanion hole (OAH) forming residues; other site
1282356002600	trimer interface [polypeptide binding]; other site
1282356002601	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1282356002602	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1282356002603	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1282356002604	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
1282356002605	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1282356002606	dimer interface [polypeptide binding]; other site
1282356002607	active site
1282356002608	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
1282356002609	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
1282356002610	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1282356002611	active site
1282356002612	interdomain interaction site; other site
1282356002613	putative metal-binding site [ion binding]; other site
1282356002614	nucleotide binding site [chemical binding]; other site
1282356002615	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1282356002616	domain I; other site
1282356002617	DNA binding groove [nucleotide binding]
1282356002618	phosphate binding site [ion binding]; other site
1282356002619	domain II; other site
1282356002620	domain III; other site
1282356002621	nucleotide binding site [chemical binding]; other site
1282356002622	catalytic site [active]
1282356002623	domain IV; other site
1282356002624	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1282356002625	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1282356002626	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
1282356002627	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
1282356002628	Cell division inhibitor SulA; Region: SulA; cl01880
1282356002629	LexA repressor; Validated; Region: PRK00215
1282356002630	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
1282356002631	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1282356002632	Catalytic site [active]
1282356002633	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1282356002634	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1282356002635	Protein of unknown function (DUF3179); Region: DUF3179; pfam11376
1282356002636	beta-hexosaminidase; Provisional; Region: PRK05337
1282356002637	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1282356002638	SWIM zinc finger; Region: SWIM; pfam04434
1282356002639	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
1282356002640	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1282356002641	ATP binding site [chemical binding]; other site
1282356002642	putative Mg++ binding site [ion binding]; other site
1282356002643	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1282356002644	nucleotide binding region [chemical binding]; other site
1282356002645	ATP-binding site [chemical binding]; other site
1282356002646	Protein of unknown function (DUF2803); Region: DUF2803; pfam10972
1282356002647	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1282356002648	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1282356002649	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1282356002650	ATP binding site [chemical binding]; other site
1282356002651	putative Mg++ binding site [ion binding]; other site
1282356002652	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1282356002653	nucleotide binding region [chemical binding]; other site
1282356002654	ATP-binding site [chemical binding]; other site
1282356002655	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1282356002656	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289
1282356002657	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1282356002658	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1282356002659	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
1282356002660	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1282356002661	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1282356002662	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1282356002663	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
1282356002664	active site
1282356002665	catalytic site [active]
1282356002666	PilZ domain; Region: PilZ; pfam07238
1282356002667	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
1282356002668	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1282356002669	FtsX-like permease family; Region: FtsX; pfam02687
1282356002670	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
1282356002671	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1282356002672	Walker A/P-loop; other site
1282356002673	ATP binding site [chemical binding]; other site
1282356002674	Q-loop/lid; other site
1282356002675	ABC transporter signature motif; other site
1282356002676	Walker B; other site
1282356002677	D-loop; other site
1282356002678	H-loop/switch region; other site
1282356002679	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
1282356002680	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1282356002681	FtsX-like permease family; Region: FtsX; pfam02687
1282356002682	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
1282356002683	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
1282356002684	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
1282356002685	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
1282356002686	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
1282356002687	Domain of unknown function (DUF4404); Region: DUF4404; pfam14357
1282356002688	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1282356002689	Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853
1282356002690	PilZ domain; Region: PilZ; pfam07238
1282356002691	Response regulator receiver domain; Region: Response_reg; pfam00072
1282356002692	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356002693	active site
1282356002694	phosphorylation site [posttranslational modification]
1282356002695	intermolecular recognition site; other site
1282356002696	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
1282356002697	dimerization interface [polypeptide binding]; other site
1282356002698	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1282356002699	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1282356002700	anti sigma factor interaction site; other site
1282356002701	regulatory phosphorylation site [posttranslational modification]; other site
1282356002702	transaldolase-like protein; Provisional; Region: PTZ00411
1282356002703	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
1282356002704	active site
1282356002705	dimer interface [polypeptide binding]; other site
1282356002706	catalytic residue [active]
1282356002707	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
1282356002708	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1282356002709	FMN binding site [chemical binding]; other site
1282356002710	active site
1282356002711	catalytic residues [active]
1282356002712	substrate binding site [chemical binding]; other site
1282356002713	hypothetical protein; Provisional; Region: PRK10621
1282356002714	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1282356002715	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356002716	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356002717	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1282356002718	dimerization interface [polypeptide binding]; other site
1282356002719	Methyltransferase domain; Region: Methyltransf_24; pfam13578
1282356002720	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1282356002721	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356002722	putative substrate translocation pore; other site
1282356002723	malate:quinone oxidoreductase; Validated; Region: PRK05257
1282356002724	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
1282356002725	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356002726	LysR substrate binding domain; Region: LysR_substrate; pfam03466
1282356002727	dimerization interface [polypeptide binding]; other site
1282356002728	EamA-like transporter family; Region: EamA; pfam00892
1282356002729	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1282356002730	EamA-like transporter family; Region: EamA; cl17759
1282356002731	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
1282356002732	putative active site [active]
1282356002733	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
1282356002734	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
1282356002735	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
1282356002736	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
1282356002737	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
1282356002738	trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656
1282356002739	NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242
1282356002740	Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241
1282356002741	Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055
1282356002742	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1282356002743	?-D-glucose-1-phosphatase; Provisional; Region: PRK09456
1282356002744	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356002745	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356002746	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477
1282356002747	putative effector binding pocket; other site
1282356002748	putative dimerization interface [polypeptide binding]; other site
1282356002749	acetylornithine aminotransferase; Provisional; Region: PRK02627
1282356002750	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1282356002751	inhibitor-cofactor binding pocket; inhibition site
1282356002752	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356002753	catalytic residue [active]
1282356002754	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
1282356002755	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356002756	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1282356002757	dimerization interface [polypeptide binding]; other site
1282356002758	putative transporter; Provisional; Region: PRK11043
1282356002759	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356002760	putative substrate translocation pore; other site
1282356002761	xanthine permease; Region: pbuX; TIGR03173
1282356002762	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
1282356002763	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1282356002764	Autoinducer binding domain; Region: Autoind_bind; pfam03472
1282356002765	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1282356002766	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1282356002767	DNA binding residues [nucleotide binding]
1282356002768	dimerization interface [polypeptide binding]; other site
1282356002769	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1282356002770	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1282356002771	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356002772	dimer interface [polypeptide binding]; other site
1282356002773	conserved gate region; other site
1282356002774	putative PBP binding loops; other site
1282356002775	ABC-ATPase subunit interface; other site
1282356002776	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
1282356002777	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356002778	dimer interface [polypeptide binding]; other site
1282356002779	conserved gate region; other site
1282356002780	putative PBP binding loops; other site
1282356002781	ABC-ATPase subunit interface; other site
1282356002782	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1282356002783	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1282356002784	Walker A/P-loop; other site
1282356002785	ATP binding site [chemical binding]; other site
1282356002786	Q-loop/lid; other site
1282356002787	ABC transporter signature motif; other site
1282356002788	Walker B; other site
1282356002789	D-loop; other site
1282356002790	H-loop/switch region; other site
1282356002791	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1282356002792	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1282356002793	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1282356002794	Walker A/P-loop; other site
1282356002795	ATP binding site [chemical binding]; other site
1282356002796	Q-loop/lid; other site
1282356002797	ABC transporter signature motif; other site
1282356002798	Walker B; other site
1282356002799	D-loop; other site
1282356002800	H-loop/switch region; other site
1282356002801	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1282356002802	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1282356002803	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
1282356002804	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
1282356002805	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1282356002806	NAD(P) binding site [chemical binding]; other site
1282356002807	active site
1282356002808	phosphoglycolate phosphatase; Provisional; Region: PRK13222
1282356002809	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1282356002810	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1282356002811	motif II; other site
1282356002812	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
1282356002813	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356002814	S-adenosylmethionine binding site [chemical binding]; other site
1282356002815	N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045
1282356002816	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
1282356002817	active site
1282356002818	putative substrate binding pocket [chemical binding]; other site
1282356002819	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
1282356002820	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
1282356002821	C-terminal region of Pasteurella multocida toxin residues 569-1285; Region: PMT_C; pfam11647
1282356002822	DNA gyrase subunit A; Validated; Region: PRK05560
1282356002823	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1282356002824	CAP-like domain; other site
1282356002825	active site
1282356002826	primary dimer interface [polypeptide binding]; other site
1282356002827	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1282356002828	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1282356002829	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1282356002830	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1282356002831	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1282356002832	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1282356002833	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
1282356002834	homodimer interface [polypeptide binding]; other site
1282356002835	substrate-cofactor binding pocket; other site
1282356002836	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356002837	catalytic residue [active]
1282356002838	Chorismate mutase type II; Region: CM_2; cl00693
1282356002839	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
1282356002840	Prephenate dehydratase; Region: PDT; pfam00800
1282356002841	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1282356002842	putative L-Phe binding site [chemical binding]; other site
1282356002843	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
1282356002844	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1282356002845	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356002846	homodimer interface [polypeptide binding]; other site
1282356002847	catalytic residue [active]
1282356002848	bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK14806
1282356002849	prephenate dehydrogenase; Validated; Region: PRK08507
1282356002850	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1282356002851	hinge; other site
1282356002852	active site
1282356002853	cytidylate kinase; Provisional; Region: cmk; PRK00023
1282356002854	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1282356002855	CMP-binding site; other site
1282356002856	The sites determining sugar specificity; other site
1282356002857	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
1282356002858	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1282356002859	RNA binding site [nucleotide binding]; other site
1282356002860	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1282356002861	RNA binding site [nucleotide binding]; other site
1282356002862	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
1282356002863	RNA binding site [nucleotide binding]; other site
1282356002864	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1282356002865	RNA binding site [nucleotide binding]; other site
1282356002866	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1282356002867	RNA binding site [nucleotide binding]; other site
1282356002868	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
1282356002869	RNA binding site [nucleotide binding]; other site
1282356002870	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1282356002871	IHF dimer interface [polypeptide binding]; other site
1282356002872	IHF - DNA interface [nucleotide binding]; other site
1282356002873	Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765
1282356002874	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
1282356002875	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1282356002876	NAD(P) binding site [chemical binding]; other site
1282356002877	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1282356002878	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1282356002879	Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181
1282356002880	UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256
1282356002881	NAD binding site [chemical binding]; other site
1282356002882	substrate binding site [chemical binding]; other site
1282356002883	homodimer interface [polypeptide binding]; other site
1282356002884	active site
1282356002885	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1282356002886	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1282356002887	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1282356002888	active site
1282356002889	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1282356002890	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1282356002891	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1282356002892	active site
1282356002893	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1282356002894	Ligand Binding Site [chemical binding]; other site
1282356002895	Molecular Tunnel; other site
1282356002896	This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807
1282356002897	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088
1282356002898	putative ADP-binding pocket [chemical binding]; other site
1282356002899	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
1282356002900	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1282356002901	active site
1282356002902	dimer interface [polypeptide binding]; other site
1282356002903	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1282356002904	Ligand Binding Site [chemical binding]; other site
1282356002905	Molecular Tunnel; other site
1282356002906	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1282356002907	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
1282356002908	putative ADP-binding pocket [chemical binding]; other site
1282356002909	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1282356002910	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1282356002911	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1282356002912	inhibitor-cofactor binding pocket; inhibition site
1282356002913	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356002914	catalytic residue [active]
1282356002915	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
1282356002916	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
1282356002917	NAD(P) binding site [chemical binding]; other site
1282356002918	homodimer interface [polypeptide binding]; other site
1282356002919	substrate binding site [chemical binding]; other site
1282356002920	active site
1282356002921	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
1282356002922	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1282356002923	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1282356002924	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
1282356002925	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
1282356002926	putative trimer interface [polypeptide binding]; other site
1282356002927	putative CoA binding site [chemical binding]; other site
1282356002928	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1282356002929	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
1282356002930	Protein of unknown function (DUF2897); Region: DUF2897; pfam11446
1282356002931	ethanolamine permease; Region: 2A0305; TIGR00908
1282356002932	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
1282356002933	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
1282356002934	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1282356002935	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
1282356002936	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1282356002937	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
1282356002938	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
1282356002939	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
1282356002940	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
1282356002941	Ligand Binding Site [chemical binding]; other site
1282356002942	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356002943	dimer interface [polypeptide binding]; other site
1282356002944	phosphorylation site [posttranslational modification]
1282356002945	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356002946	ATP binding site [chemical binding]; other site
1282356002947	Mg2+ binding site [ion binding]; other site
1282356002948	G-X-G motif; other site
1282356002949	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
1282356002950	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356002951	active site
1282356002952	phosphorylation site [posttranslational modification]
1282356002953	intermolecular recognition site; other site
1282356002954	dimerization interface [polypeptide binding]; other site
1282356002955	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1282356002956	DNA binding site [nucleotide binding]
1282356002957	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1282356002958	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
1282356002959	active site
1282356002960	nucleophile elbow; other site
1282356002961	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
1282356002962	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
1282356002963	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
1282356002964	active site
1282356002965	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1282356002966	active site 2 [active]
1282356002967	active site 1 [active]
1282356002968	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
1282356002969	RHS Repeat; Region: RHS_repeat; pfam05593
1282356002970	RHS Repeat; Region: RHS_repeat; pfam05593
1282356002971	RHS Repeat; Region: RHS_repeat; cl11982
1282356002972	RHS Repeat; Region: RHS_repeat; cl11982
1282356002973	RHS Repeat; Region: RHS_repeat; pfam05593
1282356002974	RHS Repeat; Region: RHS_repeat; pfam05593
1282356002975	RHS protein; Region: RHS; pfam03527
1282356002976	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
1282356002977	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1282356002978	dimerization interface [polypeptide binding]; other site
1282356002979	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1282356002980	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356002981	dimer interface [polypeptide binding]; other site
1282356002982	putative CheW interface [polypeptide binding]; other site
1282356002983	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1282356002984	active site
1282356002985	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1282356002986	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1282356002987	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1282356002988	catalytic residue [active]
1282356002989	Predicted membrane protein [Function unknown]; Region: COG2259
1282356002990	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
1282356002991	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
1282356002992	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1282356002993	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1282356002994	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1282356002995	ABC transporter signature motif; other site
1282356002996	ABC transporter signature motif; other site
1282356002997	Walker B; other site
1282356002998	Walker B; other site
1282356002999	D-loop; other site
1282356003000	H-loop/switch region; other site
1282356003001	phosphodiesterase; Provisional; Region: PRK12704
1282356003002	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
1282356003003	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1282356003004	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1282356003005	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
1282356003006	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
1282356003007	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1282356003008	Walker A/P-loop; other site
1282356003009	ATP binding site [chemical binding]; other site
1282356003010	Q-loop/lid; other site
1282356003011	ABC transporter signature motif; other site
1282356003012	Walker B; other site
1282356003013	D-loop; other site
1282356003014	H-loop/switch region; other site
1282356003015	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
1282356003016	active site
1282356003017	catalytic triad [active]
1282356003018	oxyanion hole [active]
1282356003019	switch loop; other site
1282356003020	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1282356003021	Predicted acetyltransferase [General function prediction only]; Region: COG2388
1282356003022	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
1282356003023	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1282356003024	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1282356003025	2-dehydropantoate 2-reductase; Provisional; Region: PRK06249
1282356003026	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1282356003027	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1282356003028	5'-nucleotidase; Region: 5-nucleotidase; pfam06189
1282356003029	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1282356003030	Ligand Binding Site [chemical binding]; other site
1282356003031	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
1282356003032	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356003033	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
1282356003034	substrate binding site [chemical binding]; other site
1282356003035	dimerization interface [polypeptide binding]; other site
1282356003036	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1282356003037	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394
1282356003038	Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093
1282356003039	elongation factor P; Validated; Region: PRK00529
1282356003040	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1282356003041	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1282356003042	RNA binding site [nucleotide binding]; other site
1282356003043	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1282356003044	RNA binding site [nucleotide binding]; other site
1282356003045	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1282356003046	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356003047	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356003048	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1282356003049	dimerization interface [polypeptide binding]; other site
1282356003050	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
1282356003051	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
1282356003052	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356003053	enoyl-CoA hydratase; Provisional; Region: PRK06563
1282356003054	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1282356003055	substrate binding site [chemical binding]; other site
1282356003056	oxyanion hole (OAH) forming residues; other site
1282356003057	trimer interface [polypeptide binding]; other site
1282356003058	helicase 45; Provisional; Region: PTZ00424
1282356003059	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1282356003060	ATP binding site [chemical binding]; other site
1282356003061	Mg++ binding site [ion binding]; other site
1282356003062	motif III; other site
1282356003063	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1282356003064	nucleotide binding region [chemical binding]; other site
1282356003065	ATP-binding site [chemical binding]; other site
1282356003066	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
1282356003067	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
1282356003068	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
1282356003069	putative active site [active]
1282356003070	metal binding site [ion binding]; metal-binding site
1282356003071	thiopurine S-methyltransferase; Reviewed; Region: PRK13255
1282356003072	heat shock protein HtpX; Provisional; Region: PRK05457
1282356003073	aminotransferase AlaT; Validated; Region: PRK09265
1282356003074	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1282356003075	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356003076	homodimer interface [polypeptide binding]; other site
1282356003077	catalytic residue [active]
1282356003078	methionine sulfoxide reductase B; Provisional; Region: PRK00222
1282356003079	SelR domain; Region: SelR; pfam01641
1282356003080	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1282356003081	catalytic residues [active]
1282356003082	dimer interface [polypeptide binding]; other site
1282356003083	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356003084	dimer interface [polypeptide binding]; other site
1282356003085	phosphorylation site [posttranslational modification]
1282356003086	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356003087	ATP binding site [chemical binding]; other site
1282356003088	Mg2+ binding site [ion binding]; other site
1282356003089	G-X-G motif; other site
1282356003090	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1282356003091	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356003092	active site
1282356003093	phosphorylation site [posttranslational modification]
1282356003094	intermolecular recognition site; other site
1282356003095	dimerization interface [polypeptide binding]; other site
1282356003096	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
1282356003097	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356003098	Walker A motif; other site
1282356003099	ATP binding site [chemical binding]; other site
1282356003100	Walker B motif; other site
1282356003101	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
1282356003102	GAF domain; Region: GAF_2; pfam13185
1282356003103	hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959
1282356003104	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1282356003105	substrate binding pocket [chemical binding]; other site
1282356003106	membrane-bound complex binding site; other site
1282356003107	hinge residues; other site
1282356003108	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1282356003109	substrate binding pocket [chemical binding]; other site
1282356003110	membrane-bound complex binding site; other site
1282356003111	hinge residues; other site
1282356003112	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356003113	putative active site [active]
1282356003114	heme pocket [chemical binding]; other site
1282356003115	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356003116	dimer interface [polypeptide binding]; other site
1282356003117	phosphorylation site [posttranslational modification]
1282356003118	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356003119	ATP binding site [chemical binding]; other site
1282356003120	Mg2+ binding site [ion binding]; other site
1282356003121	G-X-G motif; other site
1282356003122	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356003123	active site
1282356003124	phosphorylation site [posttranslational modification]
1282356003125	intermolecular recognition site; other site
1282356003126	dimerization interface [polypeptide binding]; other site
1282356003127	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1282356003128	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356003129	active site
1282356003130	phosphorylation site [posttranslational modification]
1282356003131	intermolecular recognition site; other site
1282356003132	dimerization interface [polypeptide binding]; other site
1282356003133	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1282356003134	DNA binding residues [nucleotide binding]
1282356003135	dimerization interface [polypeptide binding]; other site
1282356003136	Response regulator receiver domain; Region: Response_reg; pfam00072
1282356003137	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356003138	active site
1282356003139	phosphorylation site [posttranslational modification]
1282356003140	intermolecular recognition site; other site
1282356003141	dimerization interface [polypeptide binding]; other site
1282356003142	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
1282356003143	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
1282356003144	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
1282356003145	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1282356003146	EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388
1282356003147	Predicted membrane protein [Function unknown]; Region: COG5393
1282356003148	Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575
1282356003149	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
1282356003150	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1282356003151	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
1282356003152	active site
1282356003153	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
1282356003154	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
1282356003155	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1282356003156	GTP binding site; other site
1282356003157	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1282356003158	MPT binding site; other site
1282356003159	trimer interface [polypeptide binding]; other site
1282356003160	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1282356003161	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1282356003162	dimer interface [polypeptide binding]; other site
1282356003163	putative functional site; other site
1282356003164	putative MPT binding site; other site
1282356003165	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
1282356003166	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
1282356003167	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
1282356003168	Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231
1282356003169	Walker A/P-loop; other site
1282356003170	ATP binding site [chemical binding]; other site
1282356003171	Q-loop/lid; other site
1282356003172	ABC transporter signature motif; other site
1282356003173	Walker B; other site
1282356003174	D-loop; other site
1282356003175	H-loop/switch region; other site
1282356003176	CcmB protein; Region: CcmB; cl17444
1282356003177	CcmB protein; Region: CcmB; cl17444
1282356003178	heme exporter protein CcmC; Region: ccmC; TIGR01191
1282356003179	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
1282356003180	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
1282356003181	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
1282356003182	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
1282356003183	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1282356003184	catalytic residues [active]
1282356003185	central insert; other site
1282356003186	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
1282356003187	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
1282356003188	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
1282356003189	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1282356003190	binding surface
1282356003191	TPR motif; other site
1282356003192	Guanylate kinase; Region: Guanylate_kin; pfam00625
1282356003193	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1282356003194	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1282356003195	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356003196	putative substrate translocation pore; other site
1282356003197	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
1282356003198	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1282356003199	Ion transport protein; Region: Ion_trans; pfam00520
1282356003200	Ion channel; Region: Ion_trans_2; pfam07885
1282356003201	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
1282356003202	tartronate semialdehyde reductase; Provisional; Region: PRK15059
1282356003203	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1282356003204	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
1282356003205	glyoxylate carboligase; Provisional; Region: PRK11269
1282356003206	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1282356003207	PYR/PP interface [polypeptide binding]; other site
1282356003208	dimer interface [polypeptide binding]; other site
1282356003209	TPP binding site [chemical binding]; other site
1282356003210	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1282356003211	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1282356003212	TPP-binding site [chemical binding]; other site
1282356003213	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
1282356003214	Transposase IS200 like; Region: Y1_Tnp; pfam01797
1282356003215	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
1282356003216	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1282356003217	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
1282356003218	VacJ like lipoprotein; Region: VacJ; cl01073
1282356003219	Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309
1282356003220	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
1282356003221	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1282356003222	Predicted membrane protein [Function unknown]; Region: COG3162
1282356003223	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1282356003224	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
1282356003225	Na binding site [ion binding]; other site
1282356003226	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
1282356003227	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1282356003228	dimer interface [polypeptide binding]; other site
1282356003229	active site
1282356003230	citrylCoA binding site [chemical binding]; other site
1282356003231	NADH binding [chemical binding]; other site
1282356003232	cationic pore residues; other site
1282356003233	oxalacetate/citrate binding site [chemical binding]; other site
1282356003234	coenzyme A binding site [chemical binding]; other site
1282356003235	catalytic triad [active]
1282356003236	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
1282356003237	Iron-sulfur protein interface; other site
1282356003238	proximal quinone binding site [chemical binding]; other site
1282356003239	SdhD (CybS) interface [polypeptide binding]; other site
1282356003240	proximal heme binding site [chemical binding]; other site
1282356003241	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
1282356003242	SdhC subunit interface [polypeptide binding]; other site
1282356003243	proximal heme binding site [chemical binding]; other site
1282356003244	cardiolipin binding site; other site
1282356003245	Iron-sulfur protein interface; other site
1282356003246	proximal quinone binding site [chemical binding]; other site
1282356003247	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05675
1282356003248	L-aspartate oxidase; Provisional; Region: PRK06175
1282356003249	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1282356003250	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
1282356003251	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1282356003252	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
1282356003253	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
1282356003254	TPP-binding site [chemical binding]; other site
1282356003255	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
1282356003256	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
1282356003257	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1282356003258	E3 interaction surface; other site
1282356003259	lipoyl attachment site [posttranslational modification]; other site
1282356003260	e3 binding domain; Region: E3_binding; pfam02817
1282356003261	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1282356003262	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
1282356003263	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
1282356003264	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1282356003265	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1282356003266	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
1282356003267	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
1282356003268	CoA-ligase; Region: Ligase_CoA; pfam00549
1282356003269	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
1282356003270	CoA binding domain; Region: CoA_binding; pfam02629
1282356003271	CoA-ligase; Region: Ligase_CoA; pfam00549
1282356003272	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
1282356003273	Predicted membrane protein [Function unknown]; Region: COG3821
1282356003274	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1282356003275	CoenzymeA binding site [chemical binding]; other site
1282356003276	subunit interaction site [polypeptide binding]; other site
1282356003277	PHB binding site; other site
1282356003278	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1282356003279	CoenzymeA binding site [chemical binding]; other site
1282356003280	subunit interaction site [polypeptide binding]; other site
1282356003281	PHB binding site; other site
1282356003282	heat shock protein 90; Provisional; Region: PRK05218
1282356003283	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356003284	ATP binding site [chemical binding]; other site
1282356003285	Mg2+ binding site [ion binding]; other site
1282356003286	G-X-G motif; other site
1282356003287	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1282356003288	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1282356003289	Amidohydrolase; Region: Amidohydro_2; pfam04909
1282356003290	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
1282356003291	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1282356003292	dimer interface [polypeptide binding]; other site
1282356003293	active site
1282356003294	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
1282356003295	active site 1 [active]
1282356003296	dimer interface [polypeptide binding]; other site
1282356003297	active site 2 [active]
1282356003298	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1282356003299	dimerization interface [polypeptide binding]; other site
1282356003300	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1282356003301	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356003302	dimer interface [polypeptide binding]; other site
1282356003303	phosphorylation site [posttranslational modification]
1282356003304	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356003305	ATP binding site [chemical binding]; other site
1282356003306	Mg2+ binding site [ion binding]; other site
1282356003307	G-X-G motif; other site
1282356003308	Response regulator receiver domain; Region: Response_reg; pfam00072
1282356003309	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356003310	active site
1282356003311	phosphorylation site [posttranslational modification]
1282356003312	intermolecular recognition site; other site
1282356003313	dimerization interface [polypeptide binding]; other site
1282356003314	ABC transporter substrate binding protein; Region: ABC_sub_bind; cl17301
1282356003315	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1282356003316	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1282356003317	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1282356003318	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1282356003319	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1282356003320	Domain of unknown function (DUF4389); Region: DUF4389; pfam14333
1282356003321	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1282356003322	catalytic core [active]
1282356003323	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1282356003324	CoenzymeA binding site [chemical binding]; other site
1282356003325	subunit interaction site [polypeptide binding]; other site
1282356003326	PHB binding site; other site
1282356003327	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1282356003328	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1282356003329	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
1282356003330	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1282356003331	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1282356003332	dimerization interface [polypeptide binding]; other site
1282356003333	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356003334	dimer interface [polypeptide binding]; other site
1282356003335	phosphorylation site [posttranslational modification]
1282356003336	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356003337	ATP binding site [chemical binding]; other site
1282356003338	Mg2+ binding site [ion binding]; other site
1282356003339	G-X-G motif; other site
1282356003340	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1282356003341	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356003342	active site
1282356003343	phosphorylation site [posttranslational modification]
1282356003344	intermolecular recognition site; other site
1282356003345	dimerization interface [polypeptide binding]; other site
1282356003346	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1282356003347	DNA binding site [nucleotide binding]
1282356003348	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1282356003349	active site
1282356003350	dimer interface [polypeptide binding]; other site
1282356003351	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
1282356003352	Prostaglandin dehydrogenases; Region: PGDH; cd05288
1282356003353	NAD(P) binding site [chemical binding]; other site
1282356003354	substrate binding site [chemical binding]; other site
1282356003355	dimer interface [polypeptide binding]; other site
1282356003356	short chain dehydrogenase; Provisional; Region: PRK06172
1282356003357	classical (c) SDRs; Region: SDR_c; cd05233
1282356003358	NAD(P) binding site [chemical binding]; other site
1282356003359	active site
1282356003360	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1282356003361	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1282356003362	DNA-binding site [nucleotide binding]; DNA binding site
1282356003363	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1282356003364	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356003365	homodimer interface [polypeptide binding]; other site
1282356003366	catalytic residue [active]
1282356003367	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1282356003368	dimerization interface [polypeptide binding]; other site
1282356003369	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356003370	dimer interface [polypeptide binding]; other site
1282356003371	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1282356003372	putative CheW interface [polypeptide binding]; other site
1282356003373	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1282356003374	Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063
1282356003375	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
1282356003376	hypothetical protein; Provisional; Region: PRK06156
1282356003377	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
1282356003378	active site
1282356003379	metal binding site [ion binding]; metal-binding site
1282356003380	Putative catalytic domain, repeat 1, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_1; cd09106
1282356003381	PLD-like domain; Region: PLDc_2; pfam13091
1282356003382	putative active site [active]
1282356003383	putative catalytic site [active]
1282356003384	Putative catalytic domain, repeat 2, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_2; cd09107
1282356003385	PLD-like domain; Region: PLDc_2; pfam13091
1282356003386	putative active site [active]
1282356003387	putative catalytic site [active]
1282356003388	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
1282356003389	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1282356003390	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1282356003391	N-terminal plug; other site
1282356003392	ligand-binding site [chemical binding]; other site
1282356003393	Gram-negative bacterial tonB protein; Region: TonB; cl10048
1282356003394	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1282356003395	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
1282356003396	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1282356003397	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1282356003398	PhoD-like phosphatase; Region: PhoD; pfam09423
1282356003399	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
1282356003400	putative active site [active]
1282356003401	putative metal binding site [ion binding]; other site
1282356003402	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1282356003403	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
1282356003404	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1282356003405	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1282356003406	active site
1282356003407	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
1282356003408	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1282356003409	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
1282356003410	putative C-terminal domain interface [polypeptide binding]; other site
1282356003411	putative GSH binding site (G-site) [chemical binding]; other site
1282356003412	putative dimer interface [polypeptide binding]; other site
1282356003413	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
1282356003414	putative N-terminal domain interface [polypeptide binding]; other site
1282356003415	putative dimer interface [polypeptide binding]; other site
1282356003416	putative substrate binding pocket (H-site) [chemical binding]; other site
1282356003417	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1282356003418	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1282356003419	Walker A/P-loop; other site
1282356003420	ATP binding site [chemical binding]; other site
1282356003421	Q-loop/lid; other site
1282356003422	ABC transporter signature motif; other site
1282356003423	Walker B; other site
1282356003424	D-loop; other site
1282356003425	H-loop/switch region; other site
1282356003426	inner membrane transport permease; Provisional; Region: PRK15066
1282356003427	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1282356003428	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1282356003429	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356003430	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1282356003431	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318
1282356003432	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
1282356003433	gating phenylalanine in ion channel; other site
1282356003434	H+ Antiporter protein; Region: 2A0121; TIGR00900
1282356003435	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356003436	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1282356003437	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1282356003438	putative acyl-acceptor binding pocket; other site
1282356003439	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
1282356003440	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1282356003441	Sodium Bile acid symporter family; Region: SBF; cl17470
1282356003442	recombination associated protein; Reviewed; Region: rdgC; PRK00321
1282356003443	H+ Antiporter protein; Region: 2A0121; TIGR00900
1282356003444	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356003445	putative substrate translocation pore; other site
1282356003446	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1282356003447	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1282356003448	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1282356003449	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
1282356003450	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1282356003451	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
1282356003452	domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758
1282356003453	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
1282356003454	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
1282356003455	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
1282356003456	type II secretion system protein E; Region: type_II_gspE; TIGR02533
1282356003457	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
1282356003458	Walker A motif; other site
1282356003459	ATP binding site [chemical binding]; other site
1282356003460	Walker B motif; other site
1282356003461	type II secretion system protein F; Region: GspF; TIGR02120
1282356003462	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1282356003463	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1282356003464	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
1282356003465	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
1282356003466	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
1282356003467	type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708
1282356003468	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
1282356003469	laccase, plant; Region: laccase; TIGR03389
1282356003470	general secretion pathway protein J; Validated; Region: PRK08808
1282356003471	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
1282356003472	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
1282356003473	Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741
1282356003474	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1282356003475	type II secretion system protein D; Region: type_II_gspD; TIGR02517
1282356003476	active site
1282356003477	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1282356003478	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1282356003479	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1282356003480	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1282356003481	EthD domain; Region: EthD; cl17553
1282356003482	Activator of aromatic catabolism; Region: XylR_N; pfam06505
1282356003483	V4R domain; Region: V4R; pfam02830
1282356003484	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
1282356003485	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356003486	Walker A motif; other site
1282356003487	ATP binding site [chemical binding]; other site
1282356003488	Walker B motif; other site
1282356003489	arginine finger; other site
1282356003490	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1282356003491	NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152
1282356003492	NAD(P) binding site [chemical binding]; other site
1282356003493	catalytic residues [active]
1282356003494	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1282356003495	NAD(P) binding site [chemical binding]; other site
1282356003496	3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428
1282356003497	active site
1282356003498	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
1282356003499	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1282356003500	MarR family; Region: MarR_2; pfam12802
1282356003501	p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120
1282356003502	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1282356003503	substrate binding site [chemical binding]; other site
1282356003504	oxyanion hole (OAH) forming residues; other site
1282356003505	trimer interface [polypeptide binding]; other site
1282356003506	feruloyl-CoA synthase; Reviewed; Region: PRK08180
1282356003507	Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921
1282356003508	acyl-activating enzyme (AAE) consensus motif; other site
1282356003509	putative AMP binding site [chemical binding]; other site
1282356003510	putative active site [active]
1282356003511	putative CoA binding site [chemical binding]; other site
1282356003512	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
1282356003513	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1282356003514	DNA-binding site [nucleotide binding]; DNA binding site
1282356003515	FCD domain; Region: FCD; pfam07729
1282356003516	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1282356003517	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1282356003518	FMN-binding pocket [chemical binding]; other site
1282356003519	flavin binding motif; other site
1282356003520	phosphate binding motif [ion binding]; other site
1282356003521	beta-alpha-beta structure motif; other site
1282356003522	NAD binding pocket [chemical binding]; other site
1282356003523	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1282356003524	catalytic loop [active]
1282356003525	iron binding site [ion binding]; other site
1282356003526	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1282356003527	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1282356003528	iron-sulfur cluster [ion binding]; other site
1282356003529	[2Fe-2S] cluster binding site [ion binding]; other site
1282356003530	C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878
1282356003531	alpha subunit interface [polypeptide binding]; other site
1282356003532	active site
1282356003533	substrate binding site [chemical binding]; other site
1282356003534	Fe binding site [ion binding]; other site
1282356003535	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1282356003536	Beta-lactamase; Region: Beta-lactamase; pfam00144
1282356003537	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
1282356003538	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1282356003539	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1282356003540	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1282356003541	transcriptional regulator EutR; Provisional; Region: PRK10130
1282356003542	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1282356003543	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
1282356003544	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356003545	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1282356003546	amidase; Provisional; Region: PRK07869
1282356003547	Amidase; Region: Amidase; pfam01425
1282356003548	BCCT family transporter; Region: BCCT; pfam02028
1282356003549	X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129
1282356003550	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1282356003551	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
1282356003552	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1282356003553	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356003554	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1282356003555	dimerization interface [polypeptide binding]; other site
1282356003556	Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152
1282356003557	putative heme binding pocket [chemical binding]; other site
1282356003558	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
1282356003559	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
1282356003560	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1282356003561	Protein of unknown function (DUF1232); Region: DUF1232; pfam06803
1282356003562	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1282356003563	salt bridge; other site
1282356003564	non-specific DNA binding site [nucleotide binding]; other site
1282356003565	sequence-specific DNA binding site [nucleotide binding]; other site
1282356003566	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1282356003567	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1282356003568	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1282356003569	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1282356003570	metal binding site [ion binding]; metal-binding site
1282356003571	active site
1282356003572	I-site; other site
1282356003573	carboxy-terminal protease; Provisional; Region: PRK11186
1282356003574	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1282356003575	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1282356003576	protein binding site [polypeptide binding]; other site
1282356003577	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1282356003578	Catalytic dyad [active]
1282356003579	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
1282356003580	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1282356003581	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1282356003582	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1282356003583	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1282356003584	Walker A/P-loop; other site
1282356003585	ATP binding site [chemical binding]; other site
1282356003586	Q-loop/lid; other site
1282356003587	ABC transporter signature motif; other site
1282356003588	Walker B; other site
1282356003589	D-loop; other site
1282356003590	H-loop/switch region; other site
1282356003591	TOBE domain; Region: TOBE_2; pfam08402
1282356003592	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1282356003593	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356003594	dimer interface [polypeptide binding]; other site
1282356003595	conserved gate region; other site
1282356003596	ABC-ATPase subunit interface; other site
1282356003597	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356003598	dimer interface [polypeptide binding]; other site
1282356003599	conserved gate region; other site
1282356003600	putative PBP binding loops; other site
1282356003601	ABC-ATPase subunit interface; other site
1282356003602	Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524
1282356003603	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
1282356003604	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1282356003605	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1282356003606	transcriptional regulator protein; Region: phnR; TIGR03337
1282356003607	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1282356003608	DNA-binding site [nucleotide binding]; DNA binding site
1282356003609	UTRA domain; Region: UTRA; pfam07702
1282356003610	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1282356003611	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1282356003612	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1282356003613	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1282356003614	ABC-ATPase subunit  interface; other site
1282356003615	dimer interface [polypeptide binding]; other site
1282356003616	putative PBP binding regions; other site
1282356003617	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1282356003618	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1282356003619	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
1282356003620	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1282356003621	metal binding site [ion binding]; metal-binding site
1282356003622	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1282356003623	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
1282356003624	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1282356003625	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1282356003626	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
1282356003627	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
1282356003628	DNA binding residues [nucleotide binding]
1282356003629	dimer interface [polypeptide binding]; other site
1282356003630	[2Fe-2S] cluster binding site [ion binding]; other site
1282356003631	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
1282356003632	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356003633	Walker A motif; other site
1282356003634	ATP binding site [chemical binding]; other site
1282356003635	Walker B motif; other site
1282356003636	arginine finger; other site
1282356003637	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1282356003638	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1282356003639	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1282356003640	catalytic residue [active]
1282356003641	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1282356003642	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1282356003643	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
1282356003644	active site
1282356003645	threonine and homoserine efflux system; Provisional; Region: PRK10532
1282356003646	EamA-like transporter family; Region: EamA; pfam00892
1282356003647	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
1282356003648	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1282356003649	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1282356003650	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898
1282356003651	putative hydrophobic ligand binding site [chemical binding]; other site
1282356003652	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1282356003653	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1282356003654	N-terminal plug; other site
1282356003655	ligand-binding site [chemical binding]; other site
1282356003656	DNA polymerase II; Reviewed; Region: PRK05762
1282356003657	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
1282356003658	active site
1282356003659	catalytic site [active]
1282356003660	substrate binding site [chemical binding]; other site
1282356003661	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
1282356003662	active site
1282356003663	metal-binding site
1282356003664	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1282356003665	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1282356003666	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1282356003667	N-terminal domain interface [polypeptide binding]; other site
1282356003668	dimer interface [polypeptide binding]; other site
1282356003669	substrate binding pocket (H-site) [chemical binding]; other site
1282356003670	Domain of unknown function (DUF4174); Region: DUF4174; pfam13778
1282356003671	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
1282356003672	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1282356003673	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
1282356003674	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1282356003675	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
1282356003676	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
1282356003677	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1282356003678	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1282356003679	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
1282356003680	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664
1282356003681	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1282356003682	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1282356003683	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
1282356003684	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
1282356003685	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
1282356003686	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1282356003687	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
1282356003688	active site
1282356003689	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
1282356003690	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
1282356003691	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
1282356003692	Substrate binding site; other site
1282356003693	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
1282356003694	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
1282356003695	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1282356003696	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
1282356003697	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
1282356003698	conserved cys residue [active]
1282356003699	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1282356003700	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
1282356003701	conserved cys residue [active]
1282356003702	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1282356003703	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1282356003704	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1282356003705	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
1282356003706	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
1282356003707	glucose-1-dehydrogenase; Provisional; Region: PRK08936
1282356003708	glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358
1282356003709	NAD binding site [chemical binding]; other site
1282356003710	homodimer interface [polypeptide binding]; other site
1282356003711	active site
1282356003712	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
1282356003713	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
1282356003714	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
1282356003715	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
1282356003716	Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519
1282356003717	nucleophilic elbow; other site
1282356003718	catalytic triad [active]
1282356003719	cytosine deaminase; Provisional; Region: PRK09230
1282356003720	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
1282356003721	active site
1282356003722	cytosine permease; Provisional; Region: codB; PRK11017
1282356003723	Na binding site [ion binding]; other site
1282356003724	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1282356003725	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
1282356003726	active site
1282356003727	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
1282356003728	Predicted membrane protein [Function unknown]; Region: COG3212
1282356003729	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1282356003730	Predicted membrane protein [Function unknown]; Region: COG3212
1282356003731	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1282356003732	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1282356003733	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356003734	active site
1282356003735	phosphorylation site [posttranslational modification]
1282356003736	intermolecular recognition site; other site
1282356003737	dimerization interface [polypeptide binding]; other site
1282356003738	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1282356003739	DNA binding site [nucleotide binding]
1282356003740	sensor protein PhoQ; Provisional; Region: PRK10815
1282356003741	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356003742	ATP binding site [chemical binding]; other site
1282356003743	G-X-G motif; other site
1282356003744	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1282356003745	dimerization interface [polypeptide binding]; other site
1282356003746	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1282356003747	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356003748	dimer interface [polypeptide binding]; other site
1282356003749	putative CheW interface [polypeptide binding]; other site
1282356003750	Predicted permease [General function prediction only]; Region: COG2056
1282356003751	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
1282356003752	C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322
1282356003753	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1282356003754	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1282356003755	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
1282356003756	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1282356003757	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1282356003758	shikimate binding site; other site
1282356003759	NAD(P) binding site [chemical binding]; other site
1282356003760	Protein of unknown function, DUF480; Region: DUF480; pfam04337
1282356003761	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
1282356003762	serine/threonine transporter SstT; Provisional; Region: PRK13628
1282356003763	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1282356003764	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
1282356003765	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356003766	The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429
1282356003767	putative dimerization interface [polypeptide binding]; other site
1282356003768	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
1282356003769	selenophosphate synthetase; Provisional; Region: PRK00943
1282356003770	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
1282356003771	dimerization interface [polypeptide binding]; other site
1282356003772	putative ATP binding site [chemical binding]; other site
1282356003773	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
1282356003774	Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520
1282356003775	active site residue [active]
1282356003776	Predicted permease; Region: DUF318; pfam03773
1282356003777	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1282356003778	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
1282356003779	C-terminal domain interface [polypeptide binding]; other site
1282356003780	GSH binding site (G-site) [chemical binding]; other site
1282356003781	dimer interface [polypeptide binding]; other site
1282356003782	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1282356003783	N-terminal domain interface [polypeptide binding]; other site
1282356003784	dimer interface [polypeptide binding]; other site
1282356003785	substrate binding pocket (H-site) [chemical binding]; other site
1282356003786	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
1282356003787	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
1282356003788	dimer interface [polypeptide binding]; other site
1282356003789	active site
1282356003790	Schiff base residues; other site
1282356003791	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
1282356003792	RHS Repeat; Region: RHS_repeat; pfam05593
1282356003793	RHS Repeat; Region: RHS_repeat; pfam05593
1282356003794	RHS Repeat; Region: RHS_repeat; cl11982
1282356003795	RHS Repeat; Region: RHS_repeat; pfam05593
1282356003796	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
1282356003797	RHS Repeat; Region: RHS_repeat; cl11982
1282356003798	RHS Repeat; Region: RHS_repeat; pfam05593
1282356003799	RHS Repeat; Region: RHS_repeat; cl11982
1282356003800	RHS Repeat; Region: RHS_repeat; pfam05593
1282356003801	RHS protein; Region: RHS; pfam03527
1282356003802	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
1282356003803	Protein of unknown function (DUF1615); Region: DUF1615; pfam07759
1282356003804	acetyl-CoA acetyltransferase; Provisional; Region: PRK05656
1282356003805	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1282356003806	dimer interface [polypeptide binding]; other site
1282356003807	active site
1282356003808	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
1282356003809	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
1282356003810	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356003811	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356003812	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
1282356003813	putative dimerization interface [polypeptide binding]; other site
1282356003814	NAD-dependent deacetylase; Provisional; Region: PRK05333
1282356003815	SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409
1282356003816	NAD+ binding site [chemical binding]; other site
1282356003817	substrate binding site [chemical binding]; other site
1282356003818	Zn binding site [ion binding]; other site
1282356003819	FOG: CBS domain [General function prediction only]; Region: COG0517
1282356003820	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
1282356003821	DNA topoisomerase III; Provisional; Region: PRK07726
1282356003822	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1282356003823	active site
1282356003824	putative metal-binding site [ion binding]; other site
1282356003825	putative interdomain interaction site [polypeptide binding]; other site
1282356003826	putative nucleotide binding site [chemical binding]; other site
1282356003827	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1282356003828	domain I; other site
1282356003829	DNA binding groove [nucleotide binding]
1282356003830	phosphate binding site [ion binding]; other site
1282356003831	domain II; other site
1282356003832	domain III; other site
1282356003833	nucleotide binding site [chemical binding]; other site
1282356003834	catalytic site [active]
1282356003835	domain IV; other site
1282356003836	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356003837	putative substrate translocation pore; other site
1282356003838	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1282356003839	choline dehydrogenase; Validated; Region: PRK02106
1282356003840	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1282356003841	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356003842	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356003843	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1282356003844	dimerization interface [polypeptide binding]; other site
1282356003845	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1282356003846	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1282356003847	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1282356003848	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1282356003849	non-specific DNA binding site [nucleotide binding]; other site
1282356003850	salt bridge; other site
1282356003851	sequence-specific DNA binding site [nucleotide binding]; other site
1282356003852	Cupin domain; Region: Cupin_2; pfam07883
1282356003853	Domain of unknown function (DUF3315); Region: DUF3315; pfam11776
1282356003854	Protein of unknown function (DUF1652); Region: DUF1652; pfam07865
1282356003855	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1282356003856	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356003857	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1282356003858	putative active site [active]
1282356003859	heme pocket [chemical binding]; other site
1282356003860	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356003861	putative active site [active]
1282356003862	heme pocket [chemical binding]; other site
1282356003863	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1282356003864	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1282356003865	DNA binding residues [nucleotide binding]
1282356003866	dimerization interface [polypeptide binding]; other site
1282356003867	hypothetical protein; Provisional; Region: PRK12472
1282356003868	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1282356003869	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1282356003870	catalytic residue [active]
1282356003871	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
1282356003872	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1282356003873	potential frameshift: common BLAST hit: gi|229589669|ref|YP_002871788.1| putative hydrolase
1282356003874	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1282356003875	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
1282356003876	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
1282356003877	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
1282356003878	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1282356003879	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1282356003880	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1282356003881	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1282356003882	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
1282356003883	MgtC family; Region: MgtC; pfam02308
1282356003884	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1282356003885	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356003886	active site
1282356003887	phosphorylation site [posttranslational modification]
1282356003888	intermolecular recognition site; other site
1282356003889	dimerization interface [polypeptide binding]; other site
1282356003890	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1282356003891	DNA binding residues [nucleotide binding]
1282356003892	dimerization interface [polypeptide binding]; other site
1282356003893	hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959
1282356003894	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1282356003895	substrate binding pocket [chemical binding]; other site
1282356003896	membrane-bound complex binding site; other site
1282356003897	hinge residues; other site
1282356003898	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1282356003899	substrate binding pocket [chemical binding]; other site
1282356003900	membrane-bound complex binding site; other site
1282356003901	hinge residues; other site
1282356003902	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356003903	putative active site [active]
1282356003904	heme pocket [chemical binding]; other site
1282356003905	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356003906	dimer interface [polypeptide binding]; other site
1282356003907	phosphorylation site [posttranslational modification]
1282356003908	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356003909	ATP binding site [chemical binding]; other site
1282356003910	Mg2+ binding site [ion binding]; other site
1282356003911	G-X-G motif; other site
1282356003912	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356003913	active site
1282356003914	phosphorylation site [posttranslational modification]
1282356003915	intermolecular recognition site; other site
1282356003916	dimerization interface [polypeptide binding]; other site
1282356003917	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1282356003918	putative binding surface; other site
1282356003919	active site
1282356003920	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
1282356003921	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1282356003922	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1282356003923	active site
1282356003924	catalytic tetrad [active]
1282356003925	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
1282356003926	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1282356003927	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1282356003928	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
1282356003929	active site
1282356003930	catalytic triad [active]
1282356003931	dimer interface [polypeptide binding]; other site
1282356003932	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1282356003933	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1282356003934	Coenzyme A binding pocket [chemical binding]; other site
1282356003935	phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111
1282356003936	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1282356003937	non-specific DNA binding site [nucleotide binding]; other site
1282356003938	salt bridge; other site
1282356003939	sequence-specific DNA binding site [nucleotide binding]; other site
1282356003940	response regulator; Provisional; Region: PRK09483
1282356003941	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356003942	active site
1282356003943	phosphorylation site [posttranslational modification]
1282356003944	intermolecular recognition site; other site
1282356003945	dimerization interface [polypeptide binding]; other site
1282356003946	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1282356003947	DNA binding residues [nucleotide binding]
1282356003948	dimerization interface [polypeptide binding]; other site
1282356003949	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1282356003950	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1282356003951	GIY-YIG motif/motif A; other site
1282356003952	active site
1282356003953	catalytic site [active]
1282356003954	putative DNA binding site [nucleotide binding]; other site
1282356003955	metal binding site [ion binding]; metal-binding site
1282356003956	UvrB/uvrC motif; Region: UVR; pfam02151
1282356003957	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1282356003958	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
1282356003959	Domain of unknown function (DUF4102); Region: DUF4102; pfam13356
1282356003960	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1282356003961	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1282356003962	DNA-binding site [nucleotide binding]; DNA binding site
1282356003963	FCD domain; Region: FCD; pfam07729
1282356003964	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
1282356003965	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1282356003966	active site
1282356003967	ATP binding site [chemical binding]; other site
1282356003968	substrate binding site [chemical binding]; other site
1282356003969	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
1282356003970	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1282356003971	inhibitor-cofactor binding pocket; inhibition site
1282356003972	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356003973	catalytic residue [active]
1282356003974	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
1282356003975	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
1282356003976	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1282356003977	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1282356003978	Coenzyme A binding pocket [chemical binding]; other site
1282356003979	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1282356003980	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1282356003981	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1282356003982	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
1282356003983	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599
1282356003984	active site
1282356003985	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1282356003986	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1282356003987	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1282356003988	dimerization interface [polypeptide binding]; other site
1282356003989	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356003990	dimer interface [polypeptide binding]; other site
1282356003991	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
1282356003992	putative CheW interface [polypeptide binding]; other site
1282356003993	N-terminal catalytic domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_N; cd10320
1282356003994	active site
1282356003995	catalytic site [active]
1282356003996	Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316
1282356003997	C-terminal domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_C; cd10317
1282356003998	Ca binding site [ion binding]; other site
1282356003999	substrate binding site [chemical binding]; other site
1282356004000	Pectate lyase; Region: Pec_lyase_C; cl01593
1282356004001	Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179
1282356004002	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1282356004003	Protein export membrane protein; Region: SecD_SecF; cl14618
1282356004004	Protein export membrane protein; Region: SecD_SecF; cl14618
1282356004005	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1282356004006	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1282356004007	HlyD family secretion protein; Region: HlyD_3; pfam13437
1282356004008	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
1282356004009	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1282356004010	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356004011	active site
1282356004012	phosphorylation site [posttranslational modification]
1282356004013	intermolecular recognition site; other site
1282356004014	dimerization interface [polypeptide binding]; other site
1282356004015	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1282356004016	DNA binding site [nucleotide binding]
1282356004017	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1282356004018	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1282356004019	dimerization interface [polypeptide binding]; other site
1282356004020	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356004021	dimer interface [polypeptide binding]; other site
1282356004022	phosphorylation site [posttranslational modification]
1282356004023	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356004024	ATP binding site [chemical binding]; other site
1282356004025	Mg2+ binding site [ion binding]; other site
1282356004026	G-X-G motif; other site
1282356004027	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
1282356004028	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1282356004029	MarR family; Region: MarR; pfam01047
1282356004030	Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997
1282356004031	active site
1282356004032	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1282356004033	Predicted membrane protein [Function unknown]; Region: COG2323
1282356004034	CheB methylesterase; Region: CheB_methylest; pfam01339
1282356004035	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
1282356004036	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1282356004037	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356004038	S-adenosylmethionine binding site [chemical binding]; other site
1282356004039	PAS fold; Region: PAS; pfam00989
1282356004040	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356004041	putative active site [active]
1282356004042	heme pocket [chemical binding]; other site
1282356004043	Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473
1282356004044	PAS domain; Region: PAS_10; pfam13596
1282356004045	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356004046	putative active site [active]
1282356004047	heme pocket [chemical binding]; other site
1282356004048	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1282356004049	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356004050	putative active site [active]
1282356004051	heme pocket [chemical binding]; other site
1282356004052	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356004053	dimer interface [polypeptide binding]; other site
1282356004054	phosphorylation site [posttranslational modification]
1282356004055	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356004056	ATP binding site [chemical binding]; other site
1282356004057	Mg2+ binding site [ion binding]; other site
1282356004058	G-X-G motif; other site
1282356004059	Response regulator receiver domain; Region: Response_reg; pfam00072
1282356004060	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356004061	active site
1282356004062	phosphorylation site [posttranslational modification]
1282356004063	intermolecular recognition site; other site
1282356004064	dimerization interface [polypeptide binding]; other site
1282356004065	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
1282356004066	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
1282356004067	putative molybdopterin cofactor binding site [chemical binding]; other site
1282356004068	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
1282356004069	putative molybdopterin cofactor binding site; other site
1282356004070	Protein of unknown function (DUF1264); Region: DUF1264; pfam06884
1282356004071	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
1282356004072	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1282356004073	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1282356004074	active site
1282356004075	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1282356004076	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
1282356004077	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
1282356004078	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1282356004079	active site
1282356004080	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1282356004081	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
1282356004082	conserved cys residue [active]
1282356004083	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1282356004084	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1282356004085	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356004086	dimer interface [polypeptide binding]; other site
1282356004087	conserved gate region; other site
1282356004088	ABC-ATPase subunit interface; other site
1282356004089	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1282356004090	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
1282356004091	Walker A/P-loop; other site
1282356004092	ATP binding site [chemical binding]; other site
1282356004093	Q-loop/lid; other site
1282356004094	ABC transporter signature motif; other site
1282356004095	Walker B; other site
1282356004096	D-loop; other site
1282356004097	H-loop/switch region; other site
1282356004098	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1282356004099	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356004100	dimer interface [polypeptide binding]; other site
1282356004101	conserved gate region; other site
1282356004102	putative PBP binding loops; other site
1282356004103	ABC-ATPase subunit interface; other site
1282356004104	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1282356004105	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
1282356004106	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1282356004107	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356004108	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1282356004109	dimerization interface [polypeptide binding]; other site
1282356004110	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1282356004111	FAD binding domain; Region: FAD_binding_4; pfam01565
1282356004112	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1282356004113	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1282356004114	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1282356004115	tetramer interface [polypeptide binding]; other site
1282356004116	active site
1282356004117	Mg2+/Mn2+ binding site [ion binding]; other site
1282356004118	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1282356004119	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1282356004120	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356004121	dimer interface [polypeptide binding]; other site
1282356004122	phosphorylation site [posttranslational modification]
1282356004123	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356004124	ATP binding site [chemical binding]; other site
1282356004125	Mg2+ binding site [ion binding]; other site
1282356004126	G-X-G motif; other site
1282356004127	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1282356004128	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356004129	active site
1282356004130	phosphorylation site [posttranslational modification]
1282356004131	intermolecular recognition site; other site
1282356004132	dimerization interface [polypeptide binding]; other site
1282356004133	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1282356004134	DNA binding site [nucleotide binding]
1282356004135	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1282356004136	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1282356004137	Cytochrome c; Region: Cytochrom_C; pfam00034
1282356004138	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
1282356004139	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1282356004140	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1282356004141	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1282356004142	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1282356004143	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
1282356004144	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1282356004145	catalytic loop [active]
1282356004146	iron binding site [ion binding]; other site
1282356004147	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1282356004148	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
1282356004149	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
1282356004150	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1282356004151	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1282356004152	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356004153	putative active site [active]
1282356004154	heme pocket [chemical binding]; other site
1282356004155	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356004156	dimer interface [polypeptide binding]; other site
1282356004157	phosphorylation site [posttranslational modification]
1282356004158	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356004159	ATP binding site [chemical binding]; other site
1282356004160	Mg2+ binding site [ion binding]; other site
1282356004161	G-X-G motif; other site
1282356004162	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1282356004163	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1282356004164	catalytic site [active]
1282356004165	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
1282356004166	Repair protein; Region: Repair_PSII; pfam04536
1282356004167	Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566
1282356004168	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1282356004169	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1282356004170	active site
1282356004171	catalytic tetrad [active]
1282356004172	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
1282356004173	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
1282356004174	type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362
1282356004175	Protein of unknown function (DUF770); Region: DUF770; pfam05591
1282356004176	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
1282356004177	Protein of unknown function (DUF877); Region: DUF877; pfam05943
1282356004178	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
1282356004179	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
1282356004180	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
1282356004181	type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347
1282356004182	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
1282356004183	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356004184	Walker A motif; other site
1282356004185	ATP binding site [chemical binding]; other site
1282356004186	Walker B motif; other site
1282356004187	arginine finger; other site
1282356004188	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356004189	Walker A motif; other site
1282356004190	ATP binding site [chemical binding]; other site
1282356004191	Walker B motif; other site
1282356004192	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1282356004193	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604
1282356004194	GAF domain; Region: GAF; cl17456
1282356004195	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356004196	Walker A motif; other site
1282356004197	ATP binding site [chemical binding]; other site
1282356004198	Walker B motif; other site
1282356004199	arginine finger; other site
1282356004200	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1282356004201	type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354
1282356004202	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1282356004203	phosphopeptide binding site; other site
1282356004204	type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352
1282356004205	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3522
1282356004206	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
1282356004207	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
1282356004208	type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348
1282356004209	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
1282356004210	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
1282356004211	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1282356004212	active site
1282356004213	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1282356004214	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1282356004215	active site
1282356004216	ATP binding site [chemical binding]; other site
1282356004217	substrate binding site [chemical binding]; other site
1282356004218	activation loop (A-loop); other site
1282356004219	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
1282356004220	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1282356004221	Walker A/P-loop; other site
1282356004222	ATP binding site [chemical binding]; other site
1282356004223	Q-loop/lid; other site
1282356004224	ABC transporter signature motif; other site
1282356004225	Walker B; other site
1282356004226	D-loop; other site
1282356004227	H-loop/switch region; other site
1282356004228	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1282356004229	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1282356004230	Walker A/P-loop; other site
1282356004231	ATP binding site [chemical binding]; other site
1282356004232	Q-loop/lid; other site
1282356004233	ABC transporter signature motif; other site
1282356004234	Walker B; other site
1282356004235	D-loop; other site
1282356004236	H-loop/switch region; other site
1282356004237	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1282356004238	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
1282356004239	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356004240	dimer interface [polypeptide binding]; other site
1282356004241	conserved gate region; other site
1282356004242	putative PBP binding loops; other site
1282356004243	ABC-ATPase subunit interface; other site
1282356004244	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
1282356004245	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356004246	dimer interface [polypeptide binding]; other site
1282356004247	conserved gate region; other site
1282356004248	putative PBP binding loops; other site
1282356004249	ABC-ATPase subunit interface; other site
1282356004250	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1282356004251	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
1282356004252	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1282356004253	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
1282356004254	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1282356004255	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
1282356004256	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1282356004257	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1282356004258	catalytic residue [active]
1282356004259	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1282356004260	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1282356004261	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
1282356004262	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1282356004263	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
1282356004264	RNA/DNA hybrid binding site [nucleotide binding]; other site
1282356004265	active site
1282356004266	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
1282356004267	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
1282356004268	active site
1282356004269	catalytic site [active]
1282356004270	substrate binding site [chemical binding]; other site
1282356004271	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1282356004272	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1282356004273	Coenzyme A binding pocket [chemical binding]; other site
1282356004274	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356004275	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1282356004276	dimerization interface [polypeptide binding]; other site
1282356004277	Predicted flavoprotein [General function prediction only]; Region: COG0431
1282356004278	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1282356004279	pyruvate dehydrogenase; Provisional; Region: PRK09124
1282356004280	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
1282356004281	PYR/PP interface [polypeptide binding]; other site
1282356004282	dimer interface [polypeptide binding]; other site
1282356004283	tetramer interface [polypeptide binding]; other site
1282356004284	TPP binding site [chemical binding]; other site
1282356004285	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1282356004286	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
1282356004287	TPP-binding site [chemical binding]; other site
1282356004288	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1282356004289	Old yellow enzyme (OYE)-related FMN binding domain, group 2.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733
1282356004290	putative active site [active]
1282356004291	putative FMN binding site [chemical binding]; other site
1282356004292	putative substrate binding site [chemical binding]; other site
1282356004293	putative catalytic residue [active]
1282356004294	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1282356004295	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1282356004296	DNA binding residues [nucleotide binding]
1282356004297	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
1282356004298	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
1282356004299	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1282356004300	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1282356004301	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_13; cd06324
1282356004302	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1282356004303	putative ligand binding site [chemical binding]; other site
1282356004304	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
1282356004305	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
1282356004306	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
1282356004307	substrate binding pocket [chemical binding]; other site
1282356004308	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
1282356004309	B12 binding site [chemical binding]; other site
1282356004310	cobalt ligand [ion binding]; other site
1282356004311	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
1282356004312	Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934
1282356004313	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
1282356004314	IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341
1282356004315	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
1282356004316	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
1282356004317	active site
1282356004318	SAM binding site [chemical binding]; other site
1282356004319	homodimer interface [polypeptide binding]; other site
1282356004320	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
1282356004321	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
1282356004322	Probable cobalt transporter subunit (CbtB); Region: CbtB; pfam09489
1282356004323	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
1282356004324	active site
1282356004325	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1282356004326	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
1282356004327	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1282356004328	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1282356004329	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
1282356004330	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
1282356004331	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
1282356004332	Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
1282356004333	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356004334	Walker A motif; other site
1282356004335	ATP binding site [chemical binding]; other site
1282356004336	Walker B motif; other site
1282356004337	arginine finger; other site
1282356004338	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1282356004339	metal ion-dependent adhesion site (MIDAS); other site
1282356004340	Condensation domain; Region: Condensation; pfam00668
1282356004341	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1282356004342	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1282356004343	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1282356004344	acyl-activating enzyme (AAE) consensus motif; other site
1282356004345	AMP binding site [chemical binding]; other site
1282356004346	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1282356004347	Condensation domain; Region: Condensation; pfam00668
1282356004348	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1282356004349	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1282356004350	acyl-activating enzyme (AAE) consensus motif; other site
1282356004351	AMP binding site [chemical binding]; other site
1282356004352	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1282356004353	Condensation domain; Region: Condensation; pfam00668
1282356004354	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1282356004355	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1282356004356	acyl-activating enzyme (AAE) consensus motif; other site
1282356004357	AMP binding site [chemical binding]; other site
1282356004358	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1282356004359	Condensation domain; Region: Condensation; pfam00668
1282356004360	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1282356004361	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1282356004362	acyl-activating enzyme (AAE) consensus motif; other site
1282356004363	AMP binding site [chemical binding]; other site
1282356004364	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1282356004365	Condensation domain; Region: Condensation; pfam00668
1282356004366	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1282356004367	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1282356004368	acyl-activating enzyme (AAE) consensus motif; other site
1282356004369	AMP binding site [chemical binding]; other site
1282356004370	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1282356004371	Condensation domain; Region: Condensation; pfam00668
1282356004372	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1282356004373	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1282356004374	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1282356004375	acyl-activating enzyme (AAE) consensus motif; other site
1282356004376	AMP binding site [chemical binding]; other site
1282356004377	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1282356004378	Condensation domain; Region: Condensation; pfam00668
1282356004379	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1282356004380	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1282356004381	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1282356004382	acyl-activating enzyme (AAE) consensus motif; other site
1282356004383	AMP binding site [chemical binding]; other site
1282356004384	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1282356004385	Condensation domain; Region: Condensation; pfam00668
1282356004386	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1282356004387	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1282356004388	acyl-activating enzyme (AAE) consensus motif; other site
1282356004389	AMP binding site [chemical binding]; other site
1282356004390	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1282356004391	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
1282356004392	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
1282356004393	macrolide transporter subunit MacA; Provisional; Region: PRK11578
1282356004394	HlyD family secretion protein; Region: HlyD_3; pfam13437
1282356004395	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
1282356004396	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1282356004397	Walker A/P-loop; other site
1282356004398	ATP binding site [chemical binding]; other site
1282356004399	Q-loop/lid; other site
1282356004400	ABC transporter signature motif; other site
1282356004401	Walker B; other site
1282356004402	D-loop; other site
1282356004403	H-loop/switch region; other site
1282356004404	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1282356004405	FtsX-like permease family; Region: FtsX; pfam02687
1282356004406	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
1282356004407	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1282356004408	DNA binding residues [nucleotide binding]
1282356004409	dimerization interface [polypeptide binding]; other site
1282356004410	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1282356004411	catalytic core [active]
1282356004412	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
1282356004413	active site
1282356004414	SAM binding site [chemical binding]; other site
1282356004415	homodimer interface [polypeptide binding]; other site
1282356004416	putative hydrolase; Provisional; Region: PRK11460
1282356004417	Predicted esterase [General function prediction only]; Region: COG0400
1282356004418	hypothetical protein; Provisional; Region: PRK11615
1282356004419	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
1282356004420	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
1282356004421	TrkA-N domain; Region: TrkA_N; pfam02254
1282356004422	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
1282356004423	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1282356004424	non-specific DNA binding site [nucleotide binding]; other site
1282356004425	salt bridge; other site
1282356004426	sequence-specific DNA binding site [nucleotide binding]; other site
1282356004427	Protein of unknown function (DUF726); Region: DUF726; pfam05277
1282356004428	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735
1282356004429	hypothetical protein; Provisional; Region: PRK10236
1282356004430	manganese transport protein MntH; Reviewed; Region: PRK00701
1282356004431	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1282356004432	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
1282356004433	putative active site [active]
1282356004434	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
1282356004435	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356004436	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356004437	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1282356004438	putative effector binding pocket; other site
1282356004439	dimerization interface [polypeptide binding]; other site
1282356004440	Protein of unknown function, DUF606; Region: DUF606; pfam04657
1282356004441	Protein of unknown function, DUF606; Region: DUF606; pfam04657
1282356004442	Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069
1282356004443	Purine nucleoside permease (NUP); Region: NUP; pfam06516
1282356004444	nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106
1282356004445	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
1282356004446	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1282356004447	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
1282356004448	active site
1282356004449	Isochorismatase family; Region: Isochorismatase; pfam00857
1282356004450	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
1282356004451	catalytic triad [active]
1282356004452	dimer interface [polypeptide binding]; other site
1282356004453	conserved cis-peptide bond; other site
1282356004454	LysR family transcriptional regulator; Provisional; Region: PRK14997
1282356004455	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356004456	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1282356004457	putative effector binding pocket; other site
1282356004458	dimerization interface [polypeptide binding]; other site
1282356004459	potential frameshift: common BLAST hit: gi|229591092|ref|YP_002873211.1| putative transmembrane sensory box GGDEF domain protein
1282356004460	glutamate carboxypeptidase; Reviewed; Region: PRK06133
1282356004461	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
1282356004462	metal binding site [ion binding]; metal-binding site
1282356004463	dimer interface [polypeptide binding]; other site
1282356004464	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
1282356004465	RHS Repeat; Region: RHS_repeat; pfam05593
1282356004466	RHS Repeat; Region: RHS_repeat; pfam05593
1282356004467	RHS Repeat; Region: RHS_repeat; pfam05593
1282356004468	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
1282356004469	RHS Repeat; Region: RHS_repeat; cl11982
1282356004470	RHS Repeat; Region: RHS_repeat; pfam05593
1282356004471	RHS Repeat; Region: RHS_repeat; pfam05593
1282356004472	RHS protein; Region: RHS; pfam03527
1282356004473	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
1282356004474	Pirin-related protein [General function prediction only]; Region: COG1741
1282356004475	Pirin; Region: Pirin; pfam02678
1282356004476	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
1282356004477	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1282356004478	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1282356004479	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1282356004480	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1282356004481	ligand binding site [chemical binding]; other site
1282356004482	short chain dehydrogenase; Validated; Region: PRK08264
1282356004483	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1282356004484	NAD(P) binding site [chemical binding]; other site
1282356004485	active site
1282356004486	Predicted transcriptional regulators [Transcription]; Region: COG1733
1282356004487	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1282356004488	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
1282356004489	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
1282356004490	active site
1282356004491	tetramer interface [polypeptide binding]; other site
1282356004492	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356004493	D-galactonate transporter; Region: 2A0114; TIGR00893
1282356004494	putative substrate translocation pore; other site
1282356004495	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1282356004496	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1282356004497	DNA-binding site [nucleotide binding]; DNA binding site
1282356004498	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1282356004499	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1282356004500	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1282356004501	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1282356004502	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1282356004503	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1282356004504	Protein of unknown function (DUF461); Region: DUF461; pfam04314
1282356004505	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
1282356004506	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
1282356004507	Cu(I) binding site [ion binding]; other site
1282356004508	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
1282356004509	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1282356004510	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
1282356004511	intracellular protease, PfpI family; Region: PfpI; TIGR01382
1282356004512	proposed catalytic triad [active]
1282356004513	conserved cys residue [active]
1282356004514	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
1282356004515	Protein of unknown function DUF72; Region: DUF72; pfam01904
1282356004516	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1282356004517	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1282356004518	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
1282356004519	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1282356004520	dimer interface [polypeptide binding]; other site
1282356004521	ADP-ribose binding site [chemical binding]; other site
1282356004522	active site
1282356004523	nudix motif; other site
1282356004524	metal binding site [ion binding]; metal-binding site
1282356004525	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1282356004526	DNA binding site [nucleotide binding]
1282356004527	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1282356004528	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
1282356004529	putative ligand binding site [chemical binding]; other site
1282356004530	This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511
1282356004531	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1282356004532	putative di-iron ligands [ion binding]; other site
1282356004533	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
1282356004534	[2Fe-2S] cluster binding site [ion binding]; other site
1282356004535	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
1282356004536	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1282356004537	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1282356004538	Bacitracin resistance protein BacA; Region: BacA; pfam02673
1282356004539	Predicted acetyltransferase [General function prediction only]; Region: COG5628
1282356004540	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1282356004541	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
1282356004542	conserved cys residue [active]
1282356004543	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1282356004544	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1282356004545	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1282356004546	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
1282356004547	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
1282356004548	potential catalytic triad [active]
1282356004549	conserved cys residue [active]
1282356004550	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1282356004551	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
1282356004552	FMN binding site [chemical binding]; other site
1282356004553	active site
1282356004554	substrate binding site [chemical binding]; other site
1282356004555	catalytic residue [active]
1282356004556	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
1282356004557	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
1282356004558	NAD(P) binding site [chemical binding]; other site
1282356004559	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1282356004560	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1282356004561	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1282356004562	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
1282356004563	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
1282356004564	S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672
1282356004565	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356004566	S-adenosylmethionine binding site [chemical binding]; other site
1282356004567	Predicted Fe-S protein [General function prediction only]; Region: COG3313
1282356004568	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1282356004569	dimer interface [polypeptide binding]; other site
1282356004570	putative radical transfer pathway; other site
1282356004571	diiron center [ion binding]; other site
1282356004572	tyrosyl radical; other site
1282356004573	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
1282356004574	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
1282356004575	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
1282356004576	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1282356004577	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1282356004578	metal binding site [ion binding]; metal-binding site
1282356004579	active site
1282356004580	I-site; other site
1282356004581	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1282356004582	short chain dehydrogenase; Provisional; Region: PRK06123
1282356004583	classical (c) SDRs; Region: SDR_c; cd05233
1282356004584	NAD(P) binding site [chemical binding]; other site
1282356004585	active site
1282356004586	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1282356004587	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1282356004588	DNA-binding site [nucleotide binding]; DNA binding site
1282356004589	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1282356004590	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356004591	homodimer interface [polypeptide binding]; other site
1282356004592	catalytic residue [active]
1282356004593	MgtC family; Region: MgtC; pfam02308
1282356004594	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1282356004595	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
1282356004596	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
1282356004597	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1282356004598	active site
1282356004599	homodimer interface [polypeptide binding]; other site
1282356004600	catalytic site [active]
1282356004601	acceptor binding site [chemical binding]; other site
1282356004602	trehalose synthase; Region: treS_nterm; TIGR02456
1282356004603	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
1282356004604	active site
1282356004605	catalytic site [active]
1282356004606	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
1282356004607	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
1282356004608	glycogen branching enzyme; Provisional; Region: PRK05402
1282356004609	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
1282356004610	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
1282356004611	active site
1282356004612	catalytic site [active]
1282356004613	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
1282356004614	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1282356004615	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1282356004616	metal binding site [ion binding]; metal-binding site
1282356004617	active site
1282356004618	I-site; other site
1282356004619	PAS fold; Region: PAS_4; pfam08448
1282356004620	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1282356004621	GAF domain; Region: GAF; pfam01590
1282356004622	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356004623	dimer interface [polypeptide binding]; other site
1282356004624	phosphorylation site [posttranslational modification]
1282356004625	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356004626	ATP binding site [chemical binding]; other site
1282356004627	Mg2+ binding site [ion binding]; other site
1282356004628	G-X-G motif; other site
1282356004629	Response regulator receiver domain; Region: Response_reg; pfam00072
1282356004630	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356004631	active site
1282356004632	phosphorylation site [posttranslational modification]
1282356004633	intermolecular recognition site; other site
1282356004634	dimerization interface [polypeptide binding]; other site
1282356004635	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
1282356004636	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1282356004637	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1282356004638	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1282356004639	Coenzyme A binding pocket [chemical binding]; other site
1282356004640	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812
1282356004641	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
1282356004642	dimer interface [polypeptide binding]; other site
1282356004643	active site
1282356004644	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1282356004645	substrate binding site [chemical binding]; other site
1282356004646	catalytic residue [active]
1282356004647	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
1282356004648	YheO-like PAS domain; Region: PAS_6; pfam08348
1282356004649	HTH domain; Region: HTH_22; pfam13309
1282356004650	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1282356004651	homotrimer interaction site [polypeptide binding]; other site
1282356004652	putative active site [active]
1282356004653	RNA polymerase sigma factor FecI; Provisional; Region: PRK09651
1282356004654	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1282356004655	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1282356004656	DNA binding residues [nucleotide binding]
1282356004657	fec operon regulator FecR; Reviewed; Region: PRK09774
1282356004658	FecR protein; Region: FecR; pfam04773
1282356004659	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
1282356004660	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
1282356004661	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1282356004662	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356004663	homodimer interface [polypeptide binding]; other site
1282356004664	catalytic residue [active]
1282356004665	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1282356004666	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1282356004667	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1282356004668	iron-sulfur cluster [ion binding]; other site
1282356004669	[2Fe-2S] cluster binding site [ion binding]; other site
1282356004670	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1282356004671	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1282356004672	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
1282356004673	AAA domain; Region: AAA_28; pfam13521
1282356004674	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
1282356004675	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
1282356004676	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
1282356004677	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
1282356004678	LysR family transcriptional regulator; Provisional; Region: PRK14997
1282356004679	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1282356004680	dimerization interface [polypeptide binding]; other site
1282356004681	azoreductase; Reviewed; Region: PRK00170
1282356004682	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1282356004683	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1282356004684	major facilitator superfamily transporter; Provisional; Region: PRK05122
1282356004685	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356004686	putative substrate translocation pore; other site
1282356004687	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
1282356004688	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1282356004689	Walker A/P-loop; other site
1282356004690	ATP binding site [chemical binding]; other site
1282356004691	Q-loop/lid; other site
1282356004692	ABC transporter signature motif; other site
1282356004693	Walker B; other site
1282356004694	D-loop; other site
1282356004695	H-loop/switch region; other site
1282356004696	ABC transporter; Region: ABC_tran_2; pfam12848
1282356004697	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1282356004698	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1282356004699	DNA binding site [nucleotide binding]
1282356004700	active site
1282356004701	Int/Topo IB signature motif; other site
1282356004702	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356004703	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1282356004704	putative substrate translocation pore; other site
1282356004705	Planctomycetes uncharacterized domain TIGR03067; Region: Planc_TIGR03067
1282356004706	Chain length determinant protein; Region: Wzz; cl15801
1282356004707	Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765
1282356004708	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
1282356004709	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
1282356004710	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
1282356004711	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
1282356004712	putative DNA binding site [nucleotide binding]; other site
1282356004713	putative homodimer interface [polypeptide binding]; other site
1282356004714	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
1282356004715	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
1282356004716	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
1282356004717	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
1282356004718	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
1282356004719	domain interface [polypeptide binding]; other site
1282356004720	putative active site [active]
1282356004721	catalytic site [active]
1282356004722	Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136
1282356004723	domain interface [polypeptide binding]; other site
1282356004724	putative active site [active]
1282356004725	catalytic site [active]
1282356004726	Imelysin; Region: Peptidase_M75; pfam09375
1282356004727	Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
1282356004728	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
1282356004729	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
1282356004730	Imelysin; Region: Peptidase_M75; pfam09375
1282356004731	Iron permease FTR1 family; Region: FTR1; cl00475
1282356004732	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1282356004733	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1282356004734	SurA N-terminal domain; Region: SurA_N; pfam09312
1282356004735	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1282356004736	Transposase domain (DUF772); Region: DUF772; pfam05598
1282356004737	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
1282356004738	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1282356004739	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
1282356004740	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
1282356004741	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1282356004742	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1282356004743	HlyD family secretion protein; Region: HlyD_3; pfam13437
1282356004744	Response regulator receiver domain; Region: Response_reg; pfam00072
1282356004745	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356004746	active site
1282356004747	phosphorylation site [posttranslational modification]
1282356004748	intermolecular recognition site; other site
1282356004749	dimerization interface [polypeptide binding]; other site
1282356004750	CHASE3 domain; Region: CHASE3; pfam05227
1282356004751	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1282356004752	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356004753	putative active site [active]
1282356004754	heme pocket [chemical binding]; other site
1282356004755	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356004756	dimer interface [polypeptide binding]; other site
1282356004757	phosphorylation site [posttranslational modification]
1282356004758	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356004759	ATP binding site [chemical binding]; other site
1282356004760	Mg2+ binding site [ion binding]; other site
1282356004761	G-X-G motif; other site
1282356004762	Response regulator receiver domain; Region: Response_reg; pfam00072
1282356004763	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356004764	active site
1282356004765	phosphorylation site [posttranslational modification]
1282356004766	intermolecular recognition site; other site
1282356004767	dimerization interface [polypeptide binding]; other site
1282356004768	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1282356004769	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356004770	active site
1282356004771	phosphorylation site [posttranslational modification]
1282356004772	intermolecular recognition site; other site
1282356004773	dimerization interface [polypeptide binding]; other site
1282356004774	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1282356004775	DNA binding residues [nucleotide binding]
1282356004776	dimerization interface [polypeptide binding]; other site
1282356004777	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1282356004778	Histidine kinase; Region: HisKA_3; pfam07730
1282356004779	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356004780	ATP binding site [chemical binding]; other site
1282356004781	Mg2+ binding site [ion binding]; other site
1282356004782	G-X-G motif; other site
1282356004783	SnoaL-like domain; Region: SnoaL_3; pfam13474
1282356004784	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
1282356004785	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1282356004786	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1282356004787	N-terminal plug; other site
1282356004788	ligand-binding site [chemical binding]; other site
1282356004789	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
1282356004790	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
1282356004791	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1282356004792	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1282356004793	NAD(P) binding site [chemical binding]; other site
1282356004794	catalytic residues [active]
1282356004795	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
1282356004796	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1282356004797	inhibitor-cofactor binding pocket; inhibition site
1282356004798	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356004799	catalytic residue [active]
1282356004800	Helix-turn-helix domain; Region: HTH_18; pfam12833
1282356004801	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1282356004802	dimerization interface [polypeptide binding]; other site
1282356004803	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1282356004804	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356004805	dimer interface [polypeptide binding]; other site
1282356004806	putative CheW interface [polypeptide binding]; other site
1282356004807	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
1282356004808	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356004809	putative substrate translocation pore; other site
1282356004810	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1282356004811	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1282356004812	Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106
1282356004813	NAD(P) binding site [chemical binding]; other site
1282356004814	catalytic residues [active]
1282356004815	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
1282356004816	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1282356004817	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1282356004818	Bacterial transcriptional regulator; Region: IclR; pfam01614
1282356004819	hypothetical protein; Validated; Region: PRK07586
1282356004820	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1282356004821	PYR/PP interface [polypeptide binding]; other site
1282356004822	dimer interface [polypeptide binding]; other site
1282356004823	TPP binding site [chemical binding]; other site
1282356004824	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
1282356004825	TPP-binding site [chemical binding]; other site
1282356004826	dimer interface [polypeptide binding]; other site
1282356004827	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1282356004828	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1282356004829	NAD(P) binding site [chemical binding]; other site
1282356004830	catalytic residues [active]
1282356004831	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
1282356004832	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1282356004833	NAD(P) binding site [chemical binding]; other site
1282356004834	active site
1282356004835	VPS10 domain; Region: VPS10; smart00602
1282356004836	Ycf48-like protein; Provisional; Region: PRK13684
1282356004837	The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6,  and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348
1282356004838	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1282356004839	putative active site [active]
1282356004840	putative metal binding site [ion binding]; other site
1282356004841	Amino acid synthesis; Region: AA_synth; pfam06684
1282356004842	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
1282356004843	hypothetical protein; Provisional; Region: PRK07236
1282356004844	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1282356004845	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
1282356004846	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1282356004847	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1282356004848	ABC transporter transmembrane region; Region: ABC_membrane_3; pfam13748
1282356004849	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1282356004850	ParB-like nuclease domain; Region: ParB; smart00470
1282356004851	Helix-turn-helix domain; Region: HTH_18; pfam12833
1282356004852	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1282356004853	ornithine cyclodeaminase; Validated; Region: PRK06199
1282356004854	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
1282356004855	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
1282356004856	homotrimer interaction site [polypeptide binding]; other site
1282356004857	putative active site [active]
1282356004858	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1282356004859	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1282356004860	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1282356004861	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1282356004862	Protein of unknown function, DUF393; Region: DUF393; pfam04134
1282356004863	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356004864	PAS domain; Region: PAS_9; pfam13426
1282356004865	putative active site [active]
1282356004866	heme pocket [chemical binding]; other site
1282356004867	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356004868	PAS domain; Region: PAS_9; pfam13426
1282356004869	putative active site [active]
1282356004870	heme pocket [chemical binding]; other site
1282356004871	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356004872	dimer interface [polypeptide binding]; other site
1282356004873	putative CheW interface [polypeptide binding]; other site
1282356004874	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
1282356004875	dimanganese center [ion binding]; other site
1282356004876	histidine kinase; Provisional; Region: PRK13557
1282356004877	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356004878	putative active site [active]
1282356004879	heme pocket [chemical binding]; other site
1282356004880	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356004881	dimer interface [polypeptide binding]; other site
1282356004882	phosphorylation site [posttranslational modification]
1282356004883	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356004884	ATP binding site [chemical binding]; other site
1282356004885	Mg2+ binding site [ion binding]; other site
1282356004886	G-X-G motif; other site
1282356004887	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356004888	active site
1282356004889	phosphorylation site [posttranslational modification]
1282356004890	intermolecular recognition site; other site
1282356004891	dimerization interface [polypeptide binding]; other site
1282356004892	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
1282356004893	active site
1282356004894	General stress protein [General function prediction only]; Region: GsiB; COG3729
1282356004895	General stress protein [General function prediction only]; Region: GsiB; COG3729
1282356004896	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1282356004897	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1282356004898	DNA-binding site [nucleotide binding]; DNA binding site
1282356004899	FCD domain; Region: FCD; pfam07729
1282356004900	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1282356004901	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1282356004902	substrate binding pocket [chemical binding]; other site
1282356004903	membrane-bound complex binding site; other site
1282356004904	hinge residues; other site
1282356004905	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1282356004906	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356004907	dimer interface [polypeptide binding]; other site
1282356004908	conserved gate region; other site
1282356004909	putative PBP binding loops; other site
1282356004910	ABC-ATPase subunit interface; other site
1282356004911	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1282356004912	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1282356004913	Walker A/P-loop; other site
1282356004914	ATP binding site [chemical binding]; other site
1282356004915	Q-loop/lid; other site
1282356004916	ABC transporter signature motif; other site
1282356004917	Walker B; other site
1282356004918	D-loop; other site
1282356004919	H-loop/switch region; other site
1282356004920	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1282356004921	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1282356004922	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1282356004923	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1282356004924	classical (c) SDRs; Region: SDR_c; cd05233
1282356004925	NAD(P) binding site [chemical binding]; other site
1282356004926	active site
1282356004927	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356004928	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356004929	LysR substrate binding domain; Region: LysR_substrate; pfam03466
1282356004930	dimerization interface [polypeptide binding]; other site
1282356004931	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1282356004932	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1282356004933	NAD(P) binding site [chemical binding]; other site
1282356004934	active site
1282356004935	aminotransferase; Validated; Region: PRK07046
1282356004936	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1282356004937	inhibitor-cofactor binding pocket; inhibition site
1282356004938	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356004939	catalytic residue [active]
1282356004940	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1282356004941	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1282356004942	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
1282356004943	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1282356004944	NAD binding site [chemical binding]; other site
1282356004945	catalytic residues [active]
1282356004946	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1282356004947	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1282356004948	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1282356004949	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1282356004950	EamA-like transporter family; Region: EamA; pfam00892
1282356004951	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
1282356004952	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356004953	transcriptional activator TtdR; Provisional; Region: PRK09801
1282356004954	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1282356004955	dimerization interface [polypeptide binding]; other site
1282356004956	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
1282356004957	tartrate dehydrogenase; Region: TTC; TIGR02089
1282356004958	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
1282356004959	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356004960	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1282356004961	dimerization interface [polypeptide binding]; other site
1282356004962	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356004963	D-galactonate transporter; Region: 2A0114; TIGR00893
1282356004964	putative substrate translocation pore; other site
1282356004965	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
1282356004966	galactarate dehydratase; Region: galactar-dH20; TIGR03248
1282356004967	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
1282356004968	succinic semialdehyde dehydrogenase; Region: PLN02278
1282356004969	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1282356004970	tetramerization interface [polypeptide binding]; other site
1282356004971	NAD(P) binding site [chemical binding]; other site
1282356004972	catalytic residues [active]
1282356004973	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
1282356004974	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
1282356004975	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356004976	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356004977	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464
1282356004978	putative substrate binding pocket [chemical binding]; other site
1282356004979	putative dimerization interface [polypeptide binding]; other site
1282356004980	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268
1282356004981	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1282356004982	putative NAD(P) binding site [chemical binding]; other site
1282356004983	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1282356004984	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1282356004985	DNA-binding site [nucleotide binding]; DNA binding site
1282356004986	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1282356004987	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356004988	homodimer interface [polypeptide binding]; other site
1282356004989	catalytic residue [active]
1282356004990	phosphoglucomutase; Validated; Region: PRK07564
1282356004991	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
1282356004992	active site
1282356004993	substrate binding site [chemical binding]; other site
1282356004994	metal binding site [ion binding]; metal-binding site
1282356004995	Pirin-related protein [General function prediction only]; Region: COG1741
1282356004996	Pirin; Region: Pirin; pfam02678
1282356004997	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1282356004998	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1282356004999	Family description; Region: UvrD_C_2; pfam13538
1282356005000	Protein of unknown function (DUF1652); Region: DUF1652; pfam07865
1282356005001	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
1282356005002	active site
1282356005003	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1282356005004	Protease inhibitor Inh; Region: Inh; pfam02974
1282356005005	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
1282356005006	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
1282356005007	Walker A/P-loop; other site
1282356005008	ATP binding site [chemical binding]; other site
1282356005009	Q-loop/lid; other site
1282356005010	ABC transporter signature motif; other site
1282356005011	Walker B; other site
1282356005012	D-loop; other site
1282356005013	H-loop/switch region; other site
1282356005014	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1282356005015	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1282356005016	lipoyl attachment site [posttranslational modification]; other site
1282356005017	HlyD family secretion protein; Region: HlyD_3; pfam13437
1282356005018	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
1282356005019	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
1282356005020	Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848
1282356005021	catalytic triad [active]
1282356005022	putative active site [active]
1282356005023	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
1282356005024	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
1282356005025	Autotransporter beta-domain; Region: Autotransporter; smart00869
1282356005026	Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848
1282356005027	catalytic triad [active]
1282356005028	putative active site [active]
1282356005029	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
1282356005030	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
1282356005031	Autotransporter beta-domain; Region: Autotransporter; pfam03797
1282356005032	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
1282356005033	nucleophilic elbow; other site
1282356005034	catalytic triad; other site
1282356005035	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
1282356005036	This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990
1282356005037	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
1282356005038	DEAD/DEAH box helicase; Region: DEAD; pfam00270
1282356005039	DEAD_2; Region: DEAD_2; pfam06733
1282356005040	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1282356005041	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
1282356005042	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
1282356005043	Uncharacterized conserved protein [Function unknown]; Region: COG2308
1282356005044	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1282356005045	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1282356005046	radical SAM protein, TIGR01212 family; Region: TIGR01212
1282356005047	Response regulator receiver domain; Region: Response_reg; pfam00072
1282356005048	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356005049	active site
1282356005050	phosphorylation site [posttranslational modification]
1282356005051	intermolecular recognition site; other site
1282356005052	dimerization interface [polypeptide binding]; other site
1282356005053	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1282356005054	Response regulator receiver domain; Region: Response_reg; pfam00072
1282356005055	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356005056	active site
1282356005057	phosphorylation site [posttranslational modification]
1282356005058	intermolecular recognition site; other site
1282356005059	dimerization interface [polypeptide binding]; other site
1282356005060	PAS domain; Region: PAS_9; pfam13426
1282356005061	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356005062	putative active site [active]
1282356005063	heme pocket [chemical binding]; other site
1282356005064	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1282356005065	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356005066	dimer interface [polypeptide binding]; other site
1282356005067	phosphorylation site [posttranslational modification]
1282356005068	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356005069	ATP binding site [chemical binding]; other site
1282356005070	Mg2+ binding site [ion binding]; other site
1282356005071	G-X-G motif; other site
1282356005072	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1282356005073	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
1282356005074	conserved cys residue [active]
1282356005075	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1282356005076	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1282356005077	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1282356005078	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1282356005079	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1282356005080	inhibitor site; inhibition site
1282356005081	active site
1282356005082	dimer interface [polypeptide binding]; other site
1282356005083	catalytic residue [active]
1282356005084	hydroxyproline-2-epimerase; Provisional; Region: PRK13970
1282356005085	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
1282356005086	PAS fold; Region: PAS_4; pfam08448
1282356005087	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1282356005088	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1282356005089	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
1282356005090	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1282356005091	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1282356005092	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1282356005093	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1282356005094	Surface antigen; Region: Bac_surface_Ag; pfam01103
1282356005095	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1282356005096	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356005097	active site
1282356005098	phosphorylation site [posttranslational modification]
1282356005099	intermolecular recognition site; other site
1282356005100	dimerization interface [polypeptide binding]; other site
1282356005101	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1282356005102	DNA binding site [nucleotide binding]
1282356005103	HAMP domain; Region: HAMP; pfam00672
1282356005104	dimerization interface [polypeptide binding]; other site
1282356005105	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356005106	dimer interface [polypeptide binding]; other site
1282356005107	phosphorylation site [posttranslational modification]
1282356005108	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356005109	ATP binding site [chemical binding]; other site
1282356005110	Mg2+ binding site [ion binding]; other site
1282356005111	G-X-G motif; other site
1282356005112	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
1282356005113	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356005114	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447
1282356005115	putative dimerization interface [polypeptide binding]; other site
1282356005116	putative substrate binding pocket [chemical binding]; other site
1282356005117	D-galactonate transporter; Region: 2A0114; TIGR00893
1282356005118	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356005119	putative substrate translocation pore; other site
1282356005120	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
1282356005121	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
1282356005122	active site
1282356005123	tetramer interface [polypeptide binding]; other site
1282356005124	trehalose synthase, Pseudomonas stutzeri type; Region: TreS_stutzeri; TIGR02455
1282356005125	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
1282356005126	putative catalytic site [active]
1282356005127	putative phosphate binding site [ion binding]; other site
1282356005128	active site
1282356005129	metal binding site A [ion binding]; metal-binding site
1282356005130	DNA binding site [nucleotide binding]
1282356005131	putative AP binding site [nucleotide binding]; other site
1282356005132	putative metal binding site B [ion binding]; other site
1282356005133	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
1282356005134	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
1282356005135	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
1282356005136	active site
1282356005137	DNA binding site [nucleotide binding]
1282356005138	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
1282356005139	DNA binding site [nucleotide binding]
1282356005140	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
1282356005141	nucleotide binding site [chemical binding]; other site
1282356005142	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1282356005143	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1282356005144	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
1282356005145	N-terminal domain interface [polypeptide binding]; other site
1282356005146	dimer interface [polypeptide binding]; other site
1282356005147	substrate binding pocket (H-site) [chemical binding]; other site
1282356005148	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1282356005149	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1282356005150	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1282356005151	Walker A/P-loop; other site
1282356005152	ATP binding site [chemical binding]; other site
1282356005153	Q-loop/lid; other site
1282356005154	ABC transporter signature motif; other site
1282356005155	Walker B; other site
1282356005156	D-loop; other site
1282356005157	H-loop/switch region; other site
1282356005158	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
1282356005159	phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975
1282356005160	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
1282356005161	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356005162	dimer interface [polypeptide binding]; other site
1282356005163	conserved gate region; other site
1282356005164	putative PBP binding loops; other site
1282356005165	ABC-ATPase subunit interface; other site
1282356005166	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
1282356005167	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356005168	dimer interface [polypeptide binding]; other site
1282356005169	conserved gate region; other site
1282356005170	putative PBP binding loops; other site
1282356005171	ABC-ATPase subunit interface; other site
1282356005172	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14263
1282356005173	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1282356005174	Walker A/P-loop; other site
1282356005175	ATP binding site [chemical binding]; other site
1282356005176	Q-loop/lid; other site
1282356005177	ABC transporter signature motif; other site
1282356005178	Walker B; other site
1282356005179	D-loop; other site
1282356005180	H-loop/switch region; other site
1282356005181	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1282356005182	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
1282356005183	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356005184	active site
1282356005185	phosphorylation site [posttranslational modification]
1282356005186	intermolecular recognition site; other site
1282356005187	dimerization interface [polypeptide binding]; other site
1282356005188	CheB methylesterase; Region: CheB_methylest; pfam01339
1282356005189	CheD chemotactic sensory transduction; Region: CheD; cl00810
1282356005190	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1282356005191	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
1282356005192	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356005193	S-adenosylmethionine binding site [chemical binding]; other site
1282356005194	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
1282356005195	putative CheA interaction surface; other site
1282356005196	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1282356005197	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1282356005198	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356005199	dimer interface [polypeptide binding]; other site
1282356005200	putative CheW interface [polypeptide binding]; other site
1282356005201	chemotaxis protein CheA; Provisional; Region: PRK10547
1282356005202	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1282356005203	putative binding surface; other site
1282356005204	active site
1282356005205	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
1282356005206	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356005207	ATP binding site [chemical binding]; other site
1282356005208	Mg2+ binding site [ion binding]; other site
1282356005209	G-X-G motif; other site
1282356005210	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
1282356005211	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1282356005212	anti sigma factor interaction site; other site
1282356005213	regulatory phosphorylation site [posttranslational modification]; other site
1282356005214	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356005215	Response regulator receiver domain; Region: Response_reg; pfam00072
1282356005216	active site
1282356005217	phosphorylation site [posttranslational modification]
1282356005218	intermolecular recognition site; other site
1282356005219	dimerization interface [polypeptide binding]; other site
1282356005220	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013
1282356005221	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
1282356005222	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
1282356005223	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1282356005224	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1282356005225	Possible hemagglutinin (DUF637); Region: DUF637; pfam04830
1282356005226	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
1282356005227	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1282356005228	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
1282356005229	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1282356005230	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
1282356005231	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1282356005232	Possible hemagglutinin (DUF637); Region: DUF637; pfam04830
1282356005233	Fic/DOC family; Region: Fic; cl00960
1282356005234	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1282356005235	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1282356005236	active site
1282356005237	interdomain interaction site; other site
1282356005238	metal binding site [ion binding]; metal-binding site
1282356005239	DinB family; Region: DinB; cl17821
1282356005240	LysE type translocator; Region: LysE; pfam01810
1282356005241	arsenical pump membrane protein; Provisional; Region: PRK15445
1282356005242	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
1282356005243	transmembrane helices; other site
1282356005244	Predicted membrane protein [Function unknown]; Region: COG3619
1282356005245	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1282356005246	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1282356005247	Walker A/P-loop; other site
1282356005248	ATP binding site [chemical binding]; other site
1282356005249	Q-loop/lid; other site
1282356005250	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1282356005251	ABC transporter signature motif; other site
1282356005252	Walker B; other site
1282356005253	D-loop; other site
1282356005254	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1282356005255	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
1282356005256	DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659
1282356005257	active site
1282356005258	DNA binding site [nucleotide binding]
1282356005259	Int/Topo IB signature motif; other site
1282356005260	catalytic residues [active]
1282356005261	ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148
1282356005262	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1282356005263	Walker A/P-loop; other site
1282356005264	ATP binding site [chemical binding]; other site
1282356005265	Q-loop/lid; other site
1282356005266	ABC transporter signature motif; other site
1282356005267	Walker B; other site
1282356005268	D-loop; other site
1282356005269	H-loop/switch region; other site
1282356005270	TOBE domain; Region: TOBE; cl01440
1282356005271	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1282356005272	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356005273	dimer interface [polypeptide binding]; other site
1282356005274	conserved gate region; other site
1282356005275	putative PBP binding loops; other site
1282356005276	ABC-ATPase subunit interface; other site
1282356005277	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1282356005278	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1282356005279	Nitronate monooxygenase; Region: NMO; pfam03060
1282356005280	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1282356005281	FMN binding site [chemical binding]; other site
1282356005282	substrate binding site [chemical binding]; other site
1282356005283	putative catalytic residue [active]
1282356005284	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
1282356005285	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
1282356005286	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1282356005287	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1282356005288	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1282356005289	DNA binding site [nucleotide binding]
1282356005290	active site
1282356005291	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
1282356005292	Domain of unknown function (DUF1883); Region: DUF1883; pfam08980
1282356005293	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
1282356005294	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1282356005295	active site
1282356005296	tetramer interface; other site
1282356005297	glutathione reductase; Validated; Region: PRK06116
1282356005298	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1282356005299	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1282356005300	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1282356005301	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
1282356005302	Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799
1282356005303	DNA binding site [nucleotide binding]
1282356005304	dimer interface [polypeptide binding]; other site
1282356005305	active site
1282356005306	Int/Topo IB signature motif; other site
1282356005307	peroxiredoxin; Region: AhpC; TIGR03137
1282356005308	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1282356005309	dimer interface [polypeptide binding]; other site
1282356005310	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1282356005311	catalytic triad [active]
1282356005312	peroxidatic and resolving cysteines [active]
1282356005313	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
1282356005314	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
1282356005315	catalytic residue [active]
1282356005316	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
1282356005317	catalytic residues [active]
1282356005318	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1282356005319	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1282356005320	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
1282356005321	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1282356005322	dimer interface [polypeptide binding]; other site
1282356005323	active site
1282356005324	metal binding site [ion binding]; metal-binding site
1282356005325	glutathione binding site [chemical binding]; other site
1282356005326	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
1282356005327	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1282356005328	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
1282356005329	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
1282356005330	dimer interface [polypeptide binding]; other site
1282356005331	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
1282356005332	active site
1282356005333	Fe binding site [ion binding]; other site
1282356005334	Predicted permeases [General function prediction only]; Region: RarD; COG2962
1282356005335	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1282356005336	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356005337	putative substrate translocation pore; other site
1282356005338	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
1282356005339	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
1282356005340	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1282356005341	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
1282356005342	TAP-like protein; Region: Abhydrolase_4; pfam08386
1282356005343	putative acetyltransferase YhhY; Provisional; Region: PRK10140
1282356005344	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1282356005345	Coenzyme A binding pocket [chemical binding]; other site
1282356005346	Uncharacterized conserved protein [Function unknown]; Region: COG5361
1282356005347	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
1282356005348	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
1282356005349	Response regulator receiver domain; Region: Response_reg; pfam00072
1282356005350	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356005351	active site
1282356005352	phosphorylation site [posttranslational modification]
1282356005353	intermolecular recognition site; other site
1282356005354	dimerization interface [polypeptide binding]; other site
1282356005355	CHASE3 domain; Region: CHASE3; pfam05227
1282356005356	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1282356005357	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1282356005358	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356005359	dimer interface [polypeptide binding]; other site
1282356005360	phosphorylation site [posttranslational modification]
1282356005361	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356005362	ATP binding site [chemical binding]; other site
1282356005363	Mg2+ binding site [ion binding]; other site
1282356005364	G-X-G motif; other site
1282356005365	Response regulator receiver domain; Region: Response_reg; pfam00072
1282356005366	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356005367	active site
1282356005368	phosphorylation site [posttranslational modification]
1282356005369	intermolecular recognition site; other site
1282356005370	dimerization interface [polypeptide binding]; other site
1282356005371	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1282356005372	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356005373	active site
1282356005374	phosphorylation site [posttranslational modification]
1282356005375	intermolecular recognition site; other site
1282356005376	Response regulator receiver domain; Region: Response_reg; pfam00072
1282356005377	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356005378	active site
1282356005379	phosphorylation site [posttranslational modification]
1282356005380	intermolecular recognition site; other site
1282356005381	dimerization interface [polypeptide binding]; other site
1282356005382	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1282356005383	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
1282356005384	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
1282356005385	CheB methylesterase; Region: CheB_methylest; pfam01339
1282356005386	Response regulator receiver domain; Region: Response_reg; pfam00072
1282356005387	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356005388	active site
1282356005389	phosphorylation site [posttranslational modification]
1282356005390	intermolecular recognition site; other site
1282356005391	dimerization interface [polypeptide binding]; other site
1282356005392	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1282356005393	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356005394	dimer interface [polypeptide binding]; other site
1282356005395	phosphorylation site [posttranslational modification]
1282356005396	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356005397	ATP binding site [chemical binding]; other site
1282356005398	Mg2+ binding site [ion binding]; other site
1282356005399	G-X-G motif; other site
1282356005400	Response regulator receiver domain; Region: Response_reg; pfam00072
1282356005401	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356005402	active site
1282356005403	phosphorylation site [posttranslational modification]
1282356005404	intermolecular recognition site; other site
1282356005405	dimerization interface [polypeptide binding]; other site
1282356005406	Yersinia/Haemophilus virulence surface antigen; Region: Peptidase_C58; cl04145
1282356005407	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356005408	Mg2+ binding site [ion binding]; other site
1282356005409	G-X-G motif; other site
1282356005410	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356005411	phosphorylation site [posttranslational modification]
1282356005412	intermolecular recognition site; other site
1282356005413	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356005414	dimer interface [polypeptide binding]; other site
1282356005415	phosphorylation site [posttranslational modification]
1282356005416	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356005417	ATP binding site [chemical binding]; other site
1282356005418	Mg2+ binding site [ion binding]; other site
1282356005419	G-X-G motif; other site
1282356005420	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1282356005421	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356005422	active site
1282356005423	phosphorylation site [posttranslational modification]
1282356005424	intermolecular recognition site; other site
1282356005425	dimerization interface [polypeptide binding]; other site
1282356005426	circadian clock protein KaiC; Reviewed; Region: PRK09302
1282356005427	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1282356005428	Walker A motif; other site
1282356005429	ATP binding site [chemical binding]; other site
1282356005430	Walker B motif; other site
1282356005431	recA bacterial DNA recombination protein; Region: RecA; cl17211
1282356005432	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1282356005433	Walker A motif; other site
1282356005434	ATP binding site [chemical binding]; other site
1282356005435	Walker B motif; other site
1282356005436	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1282356005437	TPR motif; other site
1282356005438	binding surface
1282356005439	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1282356005440	TPR motif; other site
1282356005441	binding surface
1282356005442	TPR repeat; Region: TPR_11; pfam13414
1282356005443	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
1282356005444	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1282356005445	acyl-activating enzyme (AAE) consensus motif; other site
1282356005446	AMP binding site [chemical binding]; other site
1282356005447	active site
1282356005448	CoA binding site [chemical binding]; other site
1282356005449	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
1282356005450	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1282356005451	NAD(P) binding site [chemical binding]; other site
1282356005452	active site
1282356005453	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
1282356005454	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1282356005455	dimer interface [polypeptide binding]; other site
1282356005456	active site
1282356005457	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1282356005458	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1282356005459	active site
1282356005460	enoyl-CoA hydratase; Provisional; Region: PRK05862
1282356005461	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1282356005462	substrate binding site [chemical binding]; other site
1282356005463	oxyanion hole (OAH) forming residues; other site
1282356005464	trimer interface [polypeptide binding]; other site
1282356005465	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1282356005466	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1282356005467	active site
1282356005468	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
1282356005469	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1282356005470	substrate binding site [chemical binding]; other site
1282356005471	oxyanion hole (OAH) forming residues; other site
1282356005472	trimer interface [polypeptide binding]; other site
1282356005473	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
1282356005474	HPP family; Region: HPP; pfam04982
1282356005475	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1282356005476	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
1282356005477	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1282356005478	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1282356005479	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1282356005480	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1282356005481	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
1282356005482	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051
1282356005483	4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279
1282356005484	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1282356005485	4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394
1282356005486	Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939
1282356005487	putative active site [active]
1282356005488	putative catalytic site [active]
1282356005489	putative Zn binding site [ion binding]; other site
1282356005490	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
1282356005491	bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125
1282356005492	active site
1282356005493	substrate binding site [chemical binding]; other site
1282356005494	cosubstrate binding site; other site
1282356005495	catalytic site [active]
1282356005496	C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702
1282356005497	active site
1282356005498	hexamer interface [polypeptide binding]; other site
1282356005499	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
1282356005500	NAD binding site [chemical binding]; other site
1282356005501	substrate binding site [chemical binding]; other site
1282356005502	active site
1282356005503	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1282356005504	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1282356005505	Ligand binding site; other site
1282356005506	Putative Catalytic site; other site
1282356005507	DXD motif; other site
1282356005508	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
1282356005509	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1282356005510	active site
1282356005511	DNA binding site [nucleotide binding]
1282356005512	Int/Topo IB signature motif; other site
1282356005513	short chain dehydrogenase; Provisional; Region: PRK06701
1282356005514	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
1282356005515	NAD binding site [chemical binding]; other site
1282356005516	metal binding site [ion binding]; metal-binding site
1282356005517	active site
1282356005518	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1282356005519	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1282356005520	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356005521	dimer interface [polypeptide binding]; other site
1282356005522	putative CheW interface [polypeptide binding]; other site
1282356005523	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1282356005524	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1282356005525	substrate binding site [chemical binding]; other site
1282356005526	dimer interface [polypeptide binding]; other site
1282356005527	ATP binding site [chemical binding]; other site
1282356005528	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
1282356005529	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356005530	putative substrate translocation pore; other site
1282356005531	deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269
1282356005532	active site
1282356005533	catalytic residues [active]
1282356005534	DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681
1282356005535	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
1282356005536	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1282356005537	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1282356005538	intersubunit interface [polypeptide binding]; other site
1282356005539	active site
1282356005540	catalytic residue [active]
1282356005541	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1282356005542	active site
1282356005543	catalytic residues [active]
1282356005544	DNA binding site [nucleotide binding]
1282356005545	Int/Topo IB signature motif; other site
1282356005546	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1282356005547	DNA binding site [nucleotide binding]
1282356005548	active site
1282356005549	Int/Topo IB signature motif; other site
1282356005550	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4688
1282356005551	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1282356005552	Transposase; Region: HTH_Tnp_1; pfam01527
1282356005553	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1282356005554	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1282356005555	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1282356005556	Coenzyme A binding pocket [chemical binding]; other site
1282356005557	Nitrate and nitrite sensing; Region: NIT; pfam08376
1282356005558	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1282356005559	HAMP domain; Region: HAMP; pfam00672
1282356005560	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356005561	dimer interface [polypeptide binding]; other site
1282356005562	putative CheW interface [polypeptide binding]; other site
1282356005563	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1282356005564	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1282356005565	DNA binding site [nucleotide binding]
1282356005566	active site
1282356005567	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1282356005568	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1282356005569	tetramer interface [polypeptide binding]; other site
1282356005570	active site
1282356005571	Mg2+/Mn2+ binding site [ion binding]; other site
1282356005572	insertion element IS2 transposase InsD; Provisional; Region: PRK14702
1282356005573	HTH-like domain; Region: HTH_21; pfam13276
1282356005574	Integrase core domain; Region: rve; pfam00665
1282356005575	Integrase core domain; Region: rve_3; pfam13683
1282356005576	Transposase; Region: HTH_Tnp_1; cl17663
1282356005577	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1282356005578	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
1282356005579	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
1282356005580	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
1282356005581	Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460
1282356005582	dimer interface [polypeptide binding]; other site
1282356005583	active site
1282356005584	muconolactone delta-isomerase; Region: muco_delta; TIGR03221
1282356005585	Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318
1282356005586	muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
1282356005587	octamer interface [polypeptide binding]; other site
1282356005588	active site
1282356005589	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
1282356005590	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356005591	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1282356005592	dimerization interface [polypeptide binding]; other site
1282356005593	Flavin Reductases; Region: FlaRed; cl00801
1282356005594	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1282356005595	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1282356005596	FMN-binding pocket [chemical binding]; other site
1282356005597	flavin binding motif; other site
1282356005598	phosphate binding motif [ion binding]; other site
1282356005599	beta-alpha-beta structure motif; other site
1282356005600	NAD binding pocket [chemical binding]; other site
1282356005601	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1282356005602	catalytic loop [active]
1282356005603	iron binding site [ion binding]; other site
1282356005604	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1282356005605	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1282356005606	NAD(P) binding site [chemical binding]; other site
1282356005607	active site
1282356005608	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
1282356005609	inter-subunit interface; other site
1282356005610	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
1282356005611	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1282356005612	[2Fe-2S] cluster binding site [ion binding]; other site
1282356005613	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
1282356005614	putative alpha subunit interface [polypeptide binding]; other site
1282356005615	putative active site [active]
1282356005616	putative substrate binding site [chemical binding]; other site
1282356005617	Fe binding site [ion binding]; other site
1282356005618	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1282356005619	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1282356005620	active site
1282356005621	NIPSNAP; Region: NIPSNAP; pfam07978
1282356005622	NIPSNAP; Region: NIPSNAP; pfam07978
1282356005623	SnoaL-like domain; Region: SnoaL_4; pfam13577
1282356005624	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1282356005625	Amidase; Region: Amidase; cl11426
1282356005626	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1282356005627	MarR family; Region: MarR_2; pfam12802
1282356005628	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1282356005629	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1282356005630	NAD(P) binding site [chemical binding]; other site
1282356005631	catalytic residues [active]
1282356005632	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
1282356005633	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1282356005634	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1282356005635	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1282356005636	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356005637	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
1282356005638	putative substrate translocation pore; other site
1282356005639	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
1282356005640	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1282356005641	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
1282356005642	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1282356005643	[2Fe-2S] cluster binding site [ion binding]; other site
1282356005644	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
1282356005645	putative alpha subunit interface [polypeptide binding]; other site
1282356005646	putative active site [active]
1282356005647	putative substrate binding site [chemical binding]; other site
1282356005648	Fe binding site [ion binding]; other site
1282356005649	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1282356005650	Amidase; Region: Amidase; cl11426
1282356005651	SnoaL-like domain; Region: SnoaL_4; pfam13577
1282356005652	ornithine cyclodeaminase; Validated; Region: PRK06199
1282356005653	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
1282356005654	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
1282356005655	homotrimer interaction site [polypeptide binding]; other site
1282356005656	putative active site [active]
1282356005657	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1282356005658	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1282356005659	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356005660	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356005661	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1282356005662	dimerization interface [polypeptide binding]; other site
1282356005663	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1282356005664	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1282356005665	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1282356005666	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1282356005667	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1282356005668	NAD(P) binding site [chemical binding]; other site
1282356005669	catalytic residues [active]
1282356005670	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1282356005671	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1282356005672	FMN-binding pocket [chemical binding]; other site
1282356005673	flavin binding motif; other site
1282356005674	phosphate binding motif [ion binding]; other site
1282356005675	beta-alpha-beta structure motif; other site
1282356005676	NAD binding pocket [chemical binding]; other site
1282356005677	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1282356005678	catalytic loop [active]
1282356005679	iron binding site [ion binding]; other site
1282356005680	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
1282356005681	putative heme binding pocket [chemical binding]; other site
1282356005682	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
1282356005683	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356005684	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356005685	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
1282356005686	substrate binding pocket [chemical binding]; other site
1282356005687	dimerization interface [polypeptide binding]; other site
1282356005688	Flavin Reductases; Region: FlaRed; cl00801
1282356005689	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1282356005690	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1282356005691	active site
1282356005692	CHASE3 domain; Region: CHASE3; cl05000
1282356005693	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1282356005694	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1282356005695	HAMP domain; Region: HAMP; pfam00672
1282356005696	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356005697	dimer interface [polypeptide binding]; other site
1282356005698	putative CheW interface [polypeptide binding]; other site
1282356005699	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
1282356005700	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356005701	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1282356005702	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belong to this superfamily requires a divalent cation, such as Mg2+ or Mn2+ for their activity and contain a highly...; Region: Nudix_Hydrolase_6; cd04663
1282356005703	nudix motif; other site
1282356005704	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1282356005705	catalytic core [active]
1282356005706	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
1282356005707	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
1282356005708	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
1282356005709	Protein of unknown function (DUF1349); Region: DUF1349; pfam07081
1282356005710	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
1282356005711	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1282356005712	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
1282356005713	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1282356005714	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1282356005715	D-pathway; other site
1282356005716	Putative ubiquinol binding site [chemical binding]; other site
1282356005717	Low-spin heme (heme b) binding site [chemical binding]; other site
1282356005718	Putative water exit pathway; other site
1282356005719	Binuclear center (heme o3/CuB) [ion binding]; other site
1282356005720	K-pathway; other site
1282356005721	Putative proton exit pathway; other site
1282356005722	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
1282356005723	Subunit I/III interface [polypeptide binding]; other site
1282356005724	Subunit III/IV interface [polypeptide binding]; other site
1282356005725	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
1282356005726	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1282356005727	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1282356005728	putative NAD(P) binding site [chemical binding]; other site
1282356005729	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
1282356005730	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1282356005731	NAD binding site [chemical binding]; other site
1282356005732	catalytic Zn binding site [ion binding]; other site
1282356005733	structural Zn binding site [ion binding]; other site
1282356005734	CsbD-like; Region: CsbD; cl17424
1282356005735	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1282356005736	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356005737	active site
1282356005738	phosphorylation site [posttranslational modification]
1282356005739	intermolecular recognition site; other site
1282356005740	dimerization interface [polypeptide binding]; other site
1282356005741	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1282356005742	DNA binding residues [nucleotide binding]
1282356005743	dimerization interface [polypeptide binding]; other site
1282356005744	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1282356005745	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1282356005746	substrate binding pocket [chemical binding]; other site
1282356005747	membrane-bound complex binding site; other site
1282356005748	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1282356005749	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1282356005750	substrate binding pocket [chemical binding]; other site
1282356005751	membrane-bound complex binding site; other site
1282356005752	hinge residues; other site
1282356005753	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1282356005754	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356005755	putative active site [active]
1282356005756	heme pocket [chemical binding]; other site
1282356005757	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356005758	dimer interface [polypeptide binding]; other site
1282356005759	phosphorylation site [posttranslational modification]
1282356005760	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356005761	ATP binding site [chemical binding]; other site
1282356005762	Mg2+ binding site [ion binding]; other site
1282356005763	G-X-G motif; other site
1282356005764	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1282356005765	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356005766	active site
1282356005767	phosphorylation site [posttranslational modification]
1282356005768	intermolecular recognition site; other site
1282356005769	dimerization interface [polypeptide binding]; other site
1282356005770	Protein of unknown function (DUF1120); Region: DUF1120; cl05856
1282356005771	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
1282356005772	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1282356005773	diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938
1282356005774	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1282356005775	inhibitor-cofactor binding pocket; inhibition site
1282356005776	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356005777	catalytic residue [active]
1282356005778	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1282356005779	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1282356005780	N-terminal plug; other site
1282356005781	ligand-binding site [chemical binding]; other site
1282356005782	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
1282356005783	active site
1282356005784	iron coordination sites [ion binding]; other site
1282356005785	acyl-CoA synthetase; Validated; Region: PRK05850
1282356005786	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1282356005787	acyl-activating enzyme (AAE) consensus motif; other site
1282356005788	active site
1282356005789	Condensation domain; Region: Condensation; pfam00668
1282356005790	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1282356005791	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1282356005792	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
1282356005793	Condensation domain; Region: Condensation; pfam00668
1282356005794	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1282356005795	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1282356005796	acyl-activating enzyme (AAE) consensus motif; other site
1282356005797	AMP binding site [chemical binding]; other site
1282356005798	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1282356005799	Condensation domain; Region: Condensation; pfam00668
1282356005800	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1282356005801	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1282356005802	acyl-activating enzyme (AAE) consensus motif; other site
1282356005803	AMP binding site [chemical binding]; other site
1282356005804	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1282356005805	Condensation domain; Region: Condensation; pfam00668
1282356005806	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1282356005807	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1282356005808	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1282356005809	acyl-activating enzyme (AAE) consensus motif; other site
1282356005810	AMP binding site [chemical binding]; other site
1282356005811	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1282356005812	Condensation domain; Region: Condensation; pfam00668
1282356005813	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1282356005814	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1282356005815	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1282356005816	acyl-activating enzyme (AAE) consensus motif; other site
1282356005817	AMP binding site [chemical binding]; other site
1282356005818	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1282356005819	Condensation domain; Region: Condensation; pfam00668
1282356005820	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1282356005821	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1282356005822	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1282356005823	acyl-activating enzyme (AAE) consensus motif; other site
1282356005824	AMP binding site [chemical binding]; other site
1282356005825	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1282356005826	Condensation domain; Region: Condensation; pfam00668
1282356005827	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1282356005828	Condensation domain; Region: Condensation; pfam00668
1282356005829	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1282356005830	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1282356005831	acyl-activating enzyme (AAE) consensus motif; other site
1282356005832	AMP binding site [chemical binding]; other site
1282356005833	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1282356005834	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1282356005835	Condensation domain; Region: Condensation; pfam00668
1282356005836	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1282356005837	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1282356005838	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1282356005839	acyl-activating enzyme (AAE) consensus motif; other site
1282356005840	AMP binding site [chemical binding]; other site
1282356005841	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1282356005842	Condensation domain; Region: Condensation; pfam00668
1282356005843	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1282356005844	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1282356005845	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
1282356005846	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1282356005847	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1282356005848	acyl-activating enzyme (AAE) consensus motif; other site
1282356005849	AMP binding site [chemical binding]; other site
1282356005850	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1282356005851	ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615
1282356005852	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1282356005853	Walker A/P-loop; other site
1282356005854	ATP binding site [chemical binding]; other site
1282356005855	Q-loop/lid; other site
1282356005856	ABC transporter signature motif; other site
1282356005857	Walker B; other site
1282356005858	D-loop; other site
1282356005859	H-loop/switch region; other site
1282356005860	siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951
1282356005861	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
1282356005862	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
1282356005863	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
1282356005864	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356005865	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1282356005866	putative active site [active]
1282356005867	heme pocket [chemical binding]; other site
1282356005868	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356005869	putative active site [active]
1282356005870	heme pocket [chemical binding]; other site
1282356005871	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1282356005872	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356005873	dimer interface [polypeptide binding]; other site
1282356005874	putative CheW interface [polypeptide binding]; other site
1282356005875	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1282356005876	homotrimer interaction site [polypeptide binding]; other site
1282356005877	putative active site [active]
1282356005878	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1282356005879	Peptidase family U32; Region: Peptidase_U32; pfam01136
1282356005880	Collagenase; Region: DUF3656; pfam12392
1282356005881	Transposase IS200 like; Region: Y1_Tnp; pfam01797
1282356005882	D-xylulose kinase; Region: XylB; TIGR01312
1282356005883	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
1282356005884	N- and C-terminal domain interface [polypeptide binding]; other site
1282356005885	active site
1282356005886	MgATP binding site [chemical binding]; other site
1282356005887	catalytic site [active]
1282356005888	metal binding site [ion binding]; metal-binding site
1282356005889	xylulose binding site [chemical binding]; other site
1282356005890	homodimer interface [polypeptide binding]; other site
1282356005891	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1282356005892	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1282356005893	DNA binding site [nucleotide binding]
1282356005894	domain linker motif; other site
1282356005895	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1282356005896	dimerization interface [polypeptide binding]; other site
1282356005897	ligand binding site [chemical binding]; other site
1282356005898	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1282356005899	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321
1282356005900	putative ligand binding site [chemical binding]; other site
1282356005901	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1282356005902	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1282356005903	TM-ABC transporter signature motif; other site
1282356005904	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1282356005905	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1282356005906	Walker A/P-loop; other site
1282356005907	ATP binding site [chemical binding]; other site
1282356005908	Q-loop/lid; other site
1282356005909	ABC transporter signature motif; other site
1282356005910	Walker B; other site
1282356005911	D-loop; other site
1282356005912	H-loop/switch region; other site
1282356005913	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1282356005914	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1282356005915	Protein of unknown function (DUF1153); Region: DUF1153; pfam06627
1282356005916	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1282356005917	H-loop/switch region; other site
1282356005918	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1282356005919	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1282356005920	dimerization interface [polypeptide binding]; other site
1282356005921	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1282356005922	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356005923	dimer interface [polypeptide binding]; other site
1282356005924	putative CheW interface [polypeptide binding]; other site
1282356005925	Penicillin amidase; Region: Penicil_amidase; pfam01804
1282356005926	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
1282356005927	Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936
1282356005928	active site
1282356005929	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
1282356005930	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1282356005931	dimerization interface [polypeptide binding]; other site
1282356005932	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1282356005933	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356005934	dimer interface [polypeptide binding]; other site
1282356005935	putative CheW interface [polypeptide binding]; other site
1282356005936	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
1282356005937	hydrophobic ligand binding site; other site
1282356005938	Predicted membrane protein [Function unknown]; Region: COG1238
1282356005939	Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342
1282356005940	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1282356005941	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
1282356005942	dimerization interface [polypeptide binding]; other site
1282356005943	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1282356005944	NAD binding site [chemical binding]; other site
1282356005945	ligand binding site [chemical binding]; other site
1282356005946	catalytic site [active]
1282356005947	glycogen synthase; Provisional; Region: glgA; PRK00654
1282356005948	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
1282356005949	ADP-binding pocket [chemical binding]; other site
1282356005950	homodimer interface [polypeptide binding]; other site
1282356005951	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
1282356005952	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
1282356005953	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
1282356005954	catalytic site [active]
1282356005955	active site
1282356005956	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1282356005957	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
1282356005958	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
1282356005959	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
1282356005960	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
1282356005961	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
1282356005962	active site
1282356005963	catalytic site [active]
1282356005964	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
1282356005965	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
1282356005966	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
1282356005967	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
1282356005968	active site
1282356005969	catalytic site [active]
1282356005970	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1282356005971	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1282356005972	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
1282356005973	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356005974	S-adenosylmethionine binding site [chemical binding]; other site
1282356005975	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
1282356005976	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
1282356005977	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1282356005978	N-terminal plug; other site
1282356005979	ligand-binding site [chemical binding]; other site
1282356005980	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1282356005981	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356005982	dimer interface [polypeptide binding]; other site
1282356005983	putative CheW interface [polypeptide binding]; other site
1282356005984	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1282356005985	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356005986	dimer interface [polypeptide binding]; other site
1282356005987	phosphorylation site [posttranslational modification]
1282356005988	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356005989	ATP binding site [chemical binding]; other site
1282356005990	Mg2+ binding site [ion binding]; other site
1282356005991	G-X-G motif; other site
1282356005992	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1282356005993	binding surface
1282356005994	TPR motif; other site
1282356005995	TPR repeat; Region: TPR_11; pfam13414
1282356005996	potential frameshift: common BLAST hit: gi|426408468|ref|YP_007028567.1| IS1182 family transposase
1282356005997	potential frameshift: common BLAST hit: gi|426408468|ref|YP_007028567.1| IS1182 family transposase
1282356005998	Protein of unknown function (DUF1203); Region: DUF1203; pfam06718
1282356005999	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1282356006000	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1282356006001	Coenzyme A binding pocket [chemical binding]; other site
1282356006002	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1282356006003	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1282356006004	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1282356006005	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1282356006006	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1282356006007	dimer interface [polypeptide binding]; other site
1282356006008	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356006009	catalytic residue [active]
1282356006010	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
1282356006011	FOG: CBS domain [General function prediction only]; Region: COG0517
1282356006012	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
1282356006013	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1282356006014	homodimer interface [polypeptide binding]; other site
1282356006015	substrate-cofactor binding pocket; other site
1282356006016	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356006017	catalytic residue [active]
1282356006018	YcaO domain protein; Region: TIGR03549
1282356006019	OsmC-like protein; Region: OsmC; pfam02566
1282356006020	YcaO-like family; Region: YcaO; pfam02624
1282356006021	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1282356006022	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1282356006023	motif II; other site
1282356006024	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356006025	PAS fold; Region: PAS_3; pfam08447
1282356006026	putative active site [active]
1282356006027	heme pocket [chemical binding]; other site
1282356006028	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1282356006029	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356006030	dimer interface [polypeptide binding]; other site
1282356006031	putative CheW interface [polypeptide binding]; other site
1282356006032	Isochorismatase family; Region: Isochorismatase; pfam00857
1282356006033	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
1282356006034	catalytic triad [active]
1282356006035	conserved cis-peptide bond; other site
1282356006036	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1282356006037	GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051
1282356006038	putative C-terminal domain interface [polypeptide binding]; other site
1282356006039	putative GSH binding site (G-site) [chemical binding]; other site
1282356006040	putative dimer interface [polypeptide binding]; other site
1282356006041	C-terminal, alpha helical domain of GTT2-like Glutathione S-transferases; Region: GST_C_GTT2_like; cd03182
1282356006042	putative N-terminal domain interface [polypeptide binding]; other site
1282356006043	putative dimer interface [polypeptide binding]; other site
1282356006044	putative substrate binding pocket (H-site) [chemical binding]; other site
1282356006045	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1282356006046	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1282356006047	Cache domain; Region: Cache_1; pfam02743
1282356006048	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1282356006049	dimerization interface [polypeptide binding]; other site
1282356006050	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1282356006051	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356006052	dimer interface [polypeptide binding]; other site
1282356006053	putative CheW interface [polypeptide binding]; other site
1282356006054	UV-endonuclease UvdE; Region: UvdE; cl10036
1282356006055	Predicted membrane protein (DUF2231); Region: DUF2231; cl01730
1282356006056	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
1282356006057	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356006058	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1282356006059	putative substrate translocation pore; other site
1282356006060	proline/glycine betaine transporter; Provisional; Region: PRK10642
1282356006061	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356006062	putative substrate translocation pore; other site
1282356006063	Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946
1282356006064	GAF domain; Region: GAF; pfam01590
1282356006065	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356006066	putative substrate translocation pore; other site
1282356006067	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1282356006068	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1282356006069	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1282356006070	metal binding site [ion binding]; metal-binding site
1282356006071	active site
1282356006072	I-site; other site
1282356006073	amidase; Validated; Region: PRK06565
1282356006074	Amidase; Region: Amidase; cl11426
1282356006075	Amidase; Region: Amidase; cl11426
1282356006076	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1282356006077	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1282356006078	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1282356006079	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
1282356006080	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
1282356006081	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1282356006082	beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289
1282356006083	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
1282356006084	active site
1282356006085	dinuclear metal binding site [ion binding]; other site
1282356006086	dimerization interface [polypeptide binding]; other site
1282356006087	universal stress protein UspE; Provisional; Region: PRK11175
1282356006088	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1282356006089	Ligand Binding Site [chemical binding]; other site
1282356006090	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1282356006091	Ligand Binding Site [chemical binding]; other site
1282356006092	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
1282356006093	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
1282356006094	substrate binding site [chemical binding]; other site
1282356006095	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
1282356006096	substrate binding site [chemical binding]; other site
1282356006097	ligand binding site [chemical binding]; other site
1282356006098	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
1282356006099	serine transporter; Region: stp; TIGR00814
1282356006100	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
1282356006101	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1282356006102	putative ligand binding site [chemical binding]; other site
1282356006103	NAD binding site [chemical binding]; other site
1282356006104	catalytic site [active]
1282356006105	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
1282356006106	Phosphotransferase enzyme family; Region: APH; pfam01636
1282356006107	putative active site [active]
1282356006108	putative substrate binding site [chemical binding]; other site
1282356006109	ATP binding site [chemical binding]; other site
1282356006110	short chain dehydrogenase; Provisional; Region: PRK07035
1282356006111	classical (c) SDRs; Region: SDR_c; cd05233
1282356006112	NAD(P) binding site [chemical binding]; other site
1282356006113	active site
1282356006114	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1282356006115	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027
1282356006116	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1282356006117	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1282356006118	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1282356006119	DNA-binding site [nucleotide binding]; DNA binding site
1282356006120	FCD domain; Region: FCD; pfam07729
1282356006121	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1282356006122	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1282356006123	DNA-binding site [nucleotide binding]; DNA binding site
1282356006124	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1282356006125	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
1282356006126	MoxR-like ATPases [General function prediction only]; Region: COG0714
1282356006127	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356006128	Walker A motif; other site
1282356006129	ATP binding site [chemical binding]; other site
1282356006130	Walker B motif; other site
1282356006131	arginine finger; other site
1282356006132	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1282356006133	Protein of unknown function DUF58; Region: DUF58; pfam01882
1282356006134	Domain of unknown function (DUF4381); Region: DUF4381; pfam14316
1282356006135	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
1282356006136	VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467
1282356006137	metal ion-dependent adhesion site (MIDAS); other site
1282356006138	von Willebrand factor type A domain; Region: VWA_2; pfam13519
1282356006139	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1282356006140	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1282356006141	TPR motif; other site
1282356006142	binding surface
1282356006143	Oxygen tolerance; Region: BatD; pfam13584
1282356006144	exonuclease subunit SbcD; Provisional; Region: PRK10966
1282356006145	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1282356006146	active site
1282356006147	metal binding site [ion binding]; metal-binding site
1282356006148	DNA binding site [nucleotide binding]
1282356006149	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
1282356006150	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1282356006151	AAA domain; Region: AAA_23; pfam13476
1282356006152	Walker A/P-loop; other site
1282356006153	ATP binding site [chemical binding]; other site
1282356006154	Q-loop/lid; other site
1282356006155	exonuclease subunit SbcC; Provisional; Region: PRK10246
1282356006156	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1282356006157	ABC transporter signature motif; other site
1282356006158	Walker B; other site
1282356006159	D-loop; other site
1282356006160	H-loop/switch region; other site
1282356006161	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1282356006162	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1282356006163	C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196
1282356006164	putative N-terminal domain interface [polypeptide binding]; other site
1282356006165	putative dimer interface [polypeptide binding]; other site
1282356006166	putative substrate binding pocket (H-site) [chemical binding]; other site
1282356006167	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
1282356006168	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
1282356006169	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
1282356006170	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1282356006171	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1282356006172	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1282356006173	xanthine permease; Region: pbuX; TIGR03173
1282356006174	Water Stress and Hypersensitive response; Region: WHy; smart00769
1282356006175	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
1282356006176	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1282356006177	putative active site [active]
1282356006178	catalytic triad [active]
1282356006179	putative dimer interface [polypeptide binding]; other site
1282356006180	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356006181	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356006182	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464
1282356006183	putative substrate binding pocket [chemical binding]; other site
1282356006184	putative dimerization interface [polypeptide binding]; other site
1282356006185	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
1282356006186	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
1282356006187	Peptidase M35 family; Region: M35_like; cl03449
1282356006188	active site
1282356006189	Zn binding site [ion binding]; other site
1282356006190	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
1282356006191	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
1282356006192	FecR protein; Region: FecR; pfam04773
1282356006193	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423
1282356006194	putative active site [active]
1282356006195	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1282356006196	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356006197	Walker A motif; other site
1282356006198	ATP binding site [chemical binding]; other site
1282356006199	Walker B motif; other site
1282356006200	arginine finger; other site
1282356006201	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1282356006202	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1282356006203	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1282356006204	active site
1282356006205	motif I; other site
1282356006206	motif II; other site
1282356006207	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1282356006208	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853
1282356006209	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1282356006210	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1282356006211	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1282356006212	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
1282356006213	hypothetical protein; Provisional; Region: PRK10649
1282356006214	Sulfatase; Region: Sulfatase; pfam00884
1282356006215	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
1282356006216	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1282356006217	N-terminal plug; other site
1282356006218	ligand-binding site [chemical binding]; other site
1282356006219	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1282356006220	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1282356006221	Coenzyme A binding pocket [chemical binding]; other site
1282356006222	Predicted ATPase [General function prediction only]; Region: COG1485
1282356006223	aminopeptidase N; Provisional; Region: pepN; PRK14015
1282356006224	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
1282356006225	active site
1282356006226	Zn binding site [ion binding]; other site
1282356006227	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
1282356006228	Protein of unknown function (DUF1315); Region: DUF1315; cl01215
1282356006229	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
1282356006230	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1282356006231	active site
1282356006232	metal binding site [ion binding]; metal-binding site
1282356006233	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231
1282356006234	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
1282356006235	Domain of unknown function (DUF1853); Region: DUF1853; pfam08907
1282356006236	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
1282356006237	active site
1282356006238	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
1282356006239	dimer interface [polypeptide binding]; other site
1282356006240	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1282356006241	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1282356006242	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1282356006243	catalytic residue [active]
1282356006244	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1282356006245	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1282356006246	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
1282356006247	catalytic site [active]
1282356006248	cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194
1282356006249	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1282356006250	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1282356006251	Walker A/P-loop; other site
1282356006252	ATP binding site [chemical binding]; other site
1282356006253	Q-loop/lid; other site
1282356006254	ABC transporter signature motif; other site
1282356006255	Walker B; other site
1282356006256	D-loop; other site
1282356006257	H-loop/switch region; other site
1282356006258	Secretin and TonB N terminus short domain; Region: STN; smart00965
1282356006259	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
1282356006260	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1282356006261	N-terminal plug; other site
1282356006262	ligand-binding site [chemical binding]; other site
1282356006263	Condensation domain; Region: Condensation; pfam00668
1282356006264	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1282356006265	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1282356006266	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1282356006267	acyl-activating enzyme (AAE) consensus motif; other site
1282356006268	AMP binding site [chemical binding]; other site
1282356006269	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1282356006270	Condensation domain; Region: Condensation; pfam00668
1282356006271	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1282356006272	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1282356006273	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1282356006274	acyl-activating enzyme (AAE) consensus motif; other site
1282356006275	AMP binding site [chemical binding]; other site
1282356006276	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1282356006277	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
1282356006278	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1282356006279	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1282356006280	acyl-activating enzyme (AAE) consensus motif; other site
1282356006281	AMP binding site [chemical binding]; other site
1282356006282	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1282356006283	Condensation domain; Region: Condensation; pfam00668
1282356006284	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1282356006285	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1282356006286	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1282356006287	acyl-activating enzyme (AAE) consensus motif; other site
1282356006288	AMP binding site [chemical binding]; other site
1282356006289	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1282356006290	Condensation domain; Region: Condensation; pfam00668
1282356006291	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1282356006292	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1282356006293	Condensation domain; Region: Condensation; pfam00668
1282356006294	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1282356006295	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1282356006296	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1282356006297	acyl-activating enzyme (AAE) consensus motif; other site
1282356006298	AMP binding site [chemical binding]; other site
1282356006299	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1282356006300	Condensation domain; Region: Condensation; pfam00668
1282356006301	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1282356006302	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1282356006303	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1282356006304	acyl-activating enzyme (AAE) consensus motif; other site
1282356006305	AMP binding site [chemical binding]; other site
1282356006306	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1282356006307	Condensation domain; Region: Condensation; pfam00668
1282356006308	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1282356006309	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1282356006310	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1282356006311	acyl-activating enzyme (AAE) consensus motif; other site
1282356006312	AMP binding site [chemical binding]; other site
1282356006313	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1282356006314	YcfA-like protein; Region: YcfA; cl00752
1282356006315	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
1282356006316	HicB family; Region: HicB; pfam05534
1282356006317	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1282356006318	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
1282356006319	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1282356006320	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356006321	dimer interface [polypeptide binding]; other site
1282356006322	putative CheW interface [polypeptide binding]; other site
1282356006323	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
1282356006324	Isochorismatase family; Region: Isochorismatase; pfam00857
1282356006325	catalytic triad [active]
1282356006326	metal binding site [ion binding]; metal-binding site
1282356006327	conserved cis-peptide bond; other site
1282356006328	hypothetical protein; Provisional; Region: PRK10621
1282356006329	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1282356006330	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
1282356006331	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
1282356006332	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
1282356006333	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
1282356006334	putative NADH binding site [chemical binding]; other site
1282356006335	putative active site [active]
1282356006336	nudix motif; other site
1282356006337	putative metal binding site [ion binding]; other site
1282356006338	enoyl-CoA hydratase; Provisional; Region: PRK06142
1282356006339	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1282356006340	substrate binding site [chemical binding]; other site
1282356006341	oxyanion hole (OAH) forming residues; other site
1282356006342	trimer interface [polypeptide binding]; other site
1282356006343	Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695
1282356006344	5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128
1282356006345	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1282356006346	hinge; other site
1282356006347	active site
1282356006348	SAM (Sterile alpha motif ); Region: SAM_superfamily; cl15755
1282356006349	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1282356006350	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
1282356006351	Protein export membrane protein; Region: SecD_SecF; cl14618
1282356006352	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
1282356006353	Protein export membrane protein; Region: SecD_SecF; cl14618
1282356006354	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
1282356006355	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1282356006356	HlyD family secretion protein; Region: HlyD_3; pfam13437
1282356006357	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
1282356006358	dimer interface [polypeptide binding]; other site
1282356006359	catalytic triad [active]
1282356006360	peroxidatic and resolving cysteines [active]
1282356006361	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1282356006362	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
1282356006363	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1282356006364	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1282356006365	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1282356006366	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1282356006367	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1282356006368	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356006369	dimer interface [polypeptide binding]; other site
1282356006370	conserved gate region; other site
1282356006371	putative PBP binding loops; other site
1282356006372	ABC-ATPase subunit interface; other site
1282356006373	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1282356006374	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356006375	dimer interface [polypeptide binding]; other site
1282356006376	conserved gate region; other site
1282356006377	putative PBP binding loops; other site
1282356006378	ABC-ATPase subunit interface; other site
1282356006379	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1282356006380	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1282356006381	Walker A/P-loop; other site
1282356006382	ATP binding site [chemical binding]; other site
1282356006383	Q-loop/lid; other site
1282356006384	ABC transporter signature motif; other site
1282356006385	Walker B; other site
1282356006386	D-loop; other site
1282356006387	H-loop/switch region; other site
1282356006388	TOBE domain; Region: TOBE_2; pfam08402
1282356006389	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
1282356006390	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1282356006391	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1282356006392	D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809
1282356006393	N- and C-terminal domain interface [polypeptide binding]; other site
1282356006394	D-xylulose kinase; Region: XylB; TIGR01312
1282356006395	active site
1282356006396	MgATP binding site [chemical binding]; other site
1282356006397	catalytic site [active]
1282356006398	metal binding site [ion binding]; metal-binding site
1282356006399	xylulose binding site [chemical binding]; other site
1282356006400	putative homodimer interface [polypeptide binding]; other site
1282356006401	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
1282356006402	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1282356006403	putative substrate binding site [chemical binding]; other site
1282356006404	putative ATP binding site [chemical binding]; other site
1282356006405	Protein of unknown function (DUF1652); Region: DUF1652; pfam07865
1282356006406	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
1282356006407	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1282356006408	active site
1282356006409	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
1282356006410	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
1282356006411	active site
1282356006412	dimer interface [polypeptide binding]; other site
1282356006413	non-prolyl cis peptide bond; other site
1282356006414	insertion regions; other site
1282356006415	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
1282356006416	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
1282356006417	Flavin binding site [chemical binding]; other site
1282356006418	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1282356006419	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1282356006420	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356006421	S-adenosylmethionine binding site [chemical binding]; other site
1282356006422	Protein of unknown function (DUF3455); Region: DUF3455; pfam11937
1282356006423	RNA polymerase sigma factor; Provisional; Region: PRK12537
1282356006424	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1282356006425	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1282356006426	DNA binding residues [nucleotide binding]
1282356006427	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343
1282356006428	Anti-sigma-K factor rskA; Region: RskA; pfam10099
1282356006429	sensor protein RstB; Provisional; Region: PRK10604
1282356006430	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
1282356006431	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356006432	dimer interface [polypeptide binding]; other site
1282356006433	phosphorylation site [posttranslational modification]
1282356006434	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356006435	ATP binding site [chemical binding]; other site
1282356006436	Mg2+ binding site [ion binding]; other site
1282356006437	G-X-G motif; other site
1282356006438	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1282356006439	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356006440	active site
1282356006441	phosphorylation site [posttranslational modification]
1282356006442	intermolecular recognition site; other site
1282356006443	dimerization interface [polypeptide binding]; other site
1282356006444	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1282356006445	DNA binding site [nucleotide binding]
1282356006446	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1282356006447	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1282356006448	HlyD family secretion protein; Region: HlyD_3; pfam13437
1282356006449	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
1282356006450	Protein export membrane protein; Region: SecD_SecF; cl14618
1282356006451	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
1282356006452	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343
1282356006453	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
1282356006454	Autotransporter beta-domain; Region: Autotransporter; pfam03797
1282356006455	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1282356006456	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1282356006457	DNA binding site [nucleotide binding]
1282356006458	domain linker motif; other site
1282356006459	Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283
1282356006460	putative dimerization interface [polypeptide binding]; other site
1282356006461	putative ligand binding site [chemical binding]; other site
1282356006462	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1282356006463	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1282356006464	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1282356006465	substrate binding site [chemical binding]; other site
1282356006466	ATP binding site [chemical binding]; other site
1282356006467	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356006468	D-galactonate transporter; Region: 2A0114; TIGR00893
1282356006469	putative substrate translocation pore; other site
1282356006470	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
1282356006471	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
1282356006472	dimerization interface [polypeptide binding]; other site
1282356006473	ligand binding site [chemical binding]; other site
1282356006474	NADP binding site [chemical binding]; other site
1282356006475	catalytic site [active]
1282356006476	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1282356006477	MULE transposase domain; Region: MULE; pfam10551
1282356006478	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
1282356006479	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
1282356006480	acyl-activating enzyme (AAE) consensus motif; other site
1282356006481	putative AMP binding site [chemical binding]; other site
1282356006482	putative active site [active]
1282356006483	putative CoA binding site [chemical binding]; other site
1282356006484	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
1282356006485	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1282356006486	dimer interface [polypeptide binding]; other site
1282356006487	active site
1282356006488	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1282356006489	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1282356006490	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
1282356006491	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1282356006492	NAD(P) binding site [chemical binding]; other site
1282356006493	active site
1282356006494	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
1282356006495	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1282356006496	active site
1282356006497	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
1282356006498	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349
1282356006499	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
1282356006500	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1282356006501	Di-iron ligands [ion binding]; other site
1282356006502	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1282356006503	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1282356006504	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1282356006505	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1282356006506	NAD(P) binding site [chemical binding]; other site
1282356006507	short chain dehydrogenase; Provisional; Region: PRK05650
1282356006508	active site
1282356006509	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
1282356006510	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
1282356006511	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
1282356006512	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
1282356006513	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1282356006514	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
1282356006515	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1282356006516	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
1282356006517	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356006518	dimer interface [polypeptide binding]; other site
1282356006519	conserved gate region; other site
1282356006520	putative PBP binding loops; other site
1282356006521	ABC-ATPase subunit interface; other site
1282356006522	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
1282356006523	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356006524	dimer interface [polypeptide binding]; other site
1282356006525	conserved gate region; other site
1282356006526	putative PBP binding loops; other site
1282356006527	ABC-ATPase subunit interface; other site
1282356006528	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
1282356006529	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1282356006530	Walker A/P-loop; other site
1282356006531	ATP binding site [chemical binding]; other site
1282356006532	Q-loop/lid; other site
1282356006533	ABC transporter signature motif; other site
1282356006534	Walker B; other site
1282356006535	D-loop; other site
1282356006536	H-loop/switch region; other site
1282356006537	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1282356006538	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1282356006539	Walker A/P-loop; other site
1282356006540	ATP binding site [chemical binding]; other site
1282356006541	Q-loop/lid; other site
1282356006542	ABC transporter signature motif; other site
1282356006543	Walker B; other site
1282356006544	D-loop; other site
1282356006545	H-loop/switch region; other site
1282356006546	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1282356006547	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
1282356006548	d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940
1282356006549	NAD binding site [chemical binding]; other site
1282356006550	homotetramer interface [polypeptide binding]; other site
1282356006551	homodimer interface [polypeptide binding]; other site
1282356006552	substrate binding site [chemical binding]; other site
1282356006553	active site
1282356006554	PAS fold; Region: PAS_4; pfam08448
1282356006555	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356006556	putative active site [active]
1282356006557	heme pocket [chemical binding]; other site
1282356006558	PAS fold; Region: PAS_4; pfam08448
1282356006559	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356006560	putative active site [active]
1282356006561	heme pocket [chemical binding]; other site
1282356006562	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356006563	dimer interface [polypeptide binding]; other site
1282356006564	phosphorylation site [posttranslational modification]
1282356006565	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356006566	ATP binding site [chemical binding]; other site
1282356006567	Mg2+ binding site [ion binding]; other site
1282356006568	G-X-G motif; other site
1282356006569	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356006570	Response regulator receiver domain; Region: Response_reg; pfam00072
1282356006571	active site
1282356006572	phosphorylation site [posttranslational modification]
1282356006573	intermolecular recognition site; other site
1282356006574	dimerization interface [polypeptide binding]; other site
1282356006575	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
1282356006576	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1282356006577	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1282356006578	substrate binding site [chemical binding]; other site
1282356006579	ATP binding site [chemical binding]; other site
1282356006580	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
1282356006581	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818
1282356006582	dimer interface [polypeptide binding]; other site
1282356006583	active site
1282356006584	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1282356006585	substrate binding site [chemical binding]; other site
1282356006586	catalytic residue [active]
1282356006587	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1282356006588	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
1282356006589	Bacterial transcriptional regulator; Region: IclR; pfam01614
1282356006590	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1282356006591	homotrimer interaction site [polypeptide binding]; other site
1282356006592	putative active site [active]
1282356006593	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1282356006594	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1282356006595	Walker A/P-loop; other site
1282356006596	ATP binding site [chemical binding]; other site
1282356006597	Q-loop/lid; other site
1282356006598	ABC transporter signature motif; other site
1282356006599	Walker B; other site
1282356006600	D-loop; other site
1282356006601	H-loop/switch region; other site
1282356006602	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1282356006603	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356006604	dimer interface [polypeptide binding]; other site
1282356006605	conserved gate region; other site
1282356006606	putative PBP binding loops; other site
1282356006607	ABC-ATPase subunit interface; other site
1282356006608	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356006609	dimer interface [polypeptide binding]; other site
1282356006610	conserved gate region; other site
1282356006611	putative PBP binding loops; other site
1282356006612	ABC-ATPase subunit interface; other site
1282356006613	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1282356006614	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1282356006615	substrate binding pocket [chemical binding]; other site
1282356006616	membrane-bound complex binding site; other site
1282356006617	hinge residues; other site
1282356006618	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1282356006619	catalytic residues [active]
1282356006620	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
1282356006621	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1282356006622	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1282356006623	Transporter associated domain; Region: CorC_HlyC; smart01091
1282356006624	putative S-transferase; Provisional; Region: PRK11752
1282356006625	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
1282356006626	C-terminal domain interface [polypeptide binding]; other site
1282356006627	GSH binding site (G-site) [chemical binding]; other site
1282356006628	dimer interface [polypeptide binding]; other site
1282356006629	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
1282356006630	dimer interface [polypeptide binding]; other site
1282356006631	N-terminal domain interface [polypeptide binding]; other site
1282356006632	active site
1282356006633	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1282356006634	classical (c) SDRs; Region: SDR_c; cd05233
1282356006635	NAD(P) binding site [chemical binding]; other site
1282356006636	active site
1282356006637	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
1282356006638	active site
1282356006639	catalytic residues [active]
1282356006640	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1282356006641	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1282356006642	TM-ABC transporter signature motif; other site
1282356006643	L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288
1282356006644	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1282356006645	Walker A/P-loop; other site
1282356006646	ATP binding site [chemical binding]; other site
1282356006647	Q-loop/lid; other site
1282356006648	ABC transporter signature motif; other site
1282356006649	Walker B; other site
1282356006650	D-loop; other site
1282356006651	H-loop/switch region; other site
1282356006652	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1282356006653	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
1282356006654	Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540
1282356006655	ligand binding site [chemical binding]; other site
1282356006656	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1282356006657	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1282356006658	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
1282356006659	dimer interface [polypeptide binding]; other site
1282356006660	NADP binding site [chemical binding]; other site
1282356006661	catalytic residues [active]
1282356006662	Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802
1282356006663	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
1282356006664	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1282356006665	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356006666	D-galactonate transporter; Region: 2A0114; TIGR00893
1282356006667	putative substrate translocation pore; other site
1282356006668	dihydroxy-acid dehydratase; Validated; Region: PRK06131
1282356006669	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1282356006670	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1282356006671	DNA-binding site [nucleotide binding]; DNA binding site
1282356006672	FCD domain; Region: FCD; pfam07729
1282356006673	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1282356006674	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1282356006675	N-terminal plug; other site
1282356006676	ligand-binding site [chemical binding]; other site
1282356006677	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1282356006678	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
1282356006679	active site
1282356006680	FMN binding site [chemical binding]; other site
1282356006681	substrate binding site [chemical binding]; other site
1282356006682	homotetramer interface [polypeptide binding]; other site
1282356006683	catalytic residue [active]
1282356006684	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1282356006685	dimerization interface [polypeptide binding]; other site
1282356006686	putative DNA binding site [nucleotide binding]; other site
1282356006687	putative Zn2+ binding site [ion binding]; other site
1282356006688	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1282356006689	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1282356006690	metal binding site [ion binding]; metal-binding site
1282356006691	active site
1282356006692	I-site; other site
1282356006693	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
1282356006694	Cache domain; Region: Cache_1; pfam02743
1282356006695	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1282356006696	dimerization interface [polypeptide binding]; other site
1282356006697	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1282356006698	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356006699	dimer interface [polypeptide binding]; other site
1282356006700	putative CheW interface [polypeptide binding]; other site
1282356006701	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
1282356006702	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
1282356006703	Trp docking motif [polypeptide binding]; other site
1282356006704	putative active site [active]
1282356006705	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1282356006706	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1282356006707	active site
1282356006708	catalytic tetrad [active]
1282356006709	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
1282356006710	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356006711	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356006712	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464
1282356006713	putative substrate binding pocket [chemical binding]; other site
1282356006714	putative dimerization interface [polypeptide binding]; other site
1282356006715	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1282356006716	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1282356006717	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1282356006718	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1282356006719	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1282356006720	DNA binding site [nucleotide binding]
1282356006721	Predicted ATPase [General function prediction only]; Region: COG3903
1282356006722	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1282356006723	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1282356006724	DNA binding site [nucleotide binding]
1282356006725	Predicted ATPase [General function prediction only]; Region: COG3903
1282356006726	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1282356006727	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
1282356006728	conserved cys residue [active]
1282356006729	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1282356006730	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1282356006731	Pirin-related protein [General function prediction only]; Region: COG1741
1282356006732	Pirin; Region: Pirin; pfam02678
1282356006733	putative arabinose transporter; Provisional; Region: PRK03545
1282356006734	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356006735	putative substrate translocation pore; other site
1282356006736	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1282356006737	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
1282356006738	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1282356006739	Helix-turn-helix domain; Region: HTH_18; pfam12833
1282356006740	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1282356006741	NMT1-like family; Region: NMT1_2; pfam13379
1282356006742	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1282356006743	putative heme utilization radical SAM enzyme HutW; Region: rSAM_HutW; TIGR04107
1282356006744	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
1282356006745	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1282356006746	NAD binding site [chemical binding]; other site
1282356006747	catalytic Zn binding site [ion binding]; other site
1282356006748	structural Zn binding site [ion binding]; other site
1282356006749	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
1282356006750	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356006751	S-adenosylmethionine binding site [chemical binding]; other site
1282356006752	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1282356006753	Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928
1282356006754	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1282356006755	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356006756	dimer interface [polypeptide binding]; other site
1282356006757	conserved gate region; other site
1282356006758	putative PBP binding loops; other site
1282356006759	ABC-ATPase subunit interface; other site
1282356006760	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1282356006761	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356006762	putative PBP binding loops; other site
1282356006763	dimer interface [polypeptide binding]; other site
1282356006764	ABC-ATPase subunit interface; other site
1282356006765	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1282356006766	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
1282356006767	Walker A/P-loop; other site
1282356006768	ATP binding site [chemical binding]; other site
1282356006769	Q-loop/lid; other site
1282356006770	ABC transporter signature motif; other site
1282356006771	Walker B; other site
1282356006772	D-loop; other site
1282356006773	H-loop/switch region; other site
1282356006774	TOBE domain; Region: TOBE_2; pfam08402
1282356006775	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1282356006776	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
1282356006777	Walker A/P-loop; other site
1282356006778	ATP binding site [chemical binding]; other site
1282356006779	Q-loop/lid; other site
1282356006780	ABC transporter signature motif; other site
1282356006781	Walker B; other site
1282356006782	D-loop; other site
1282356006783	H-loop/switch region; other site
1282356006784	TOBE domain; Region: TOBE_2; pfam08402
1282356006785	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
1282356006786	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356006787	Walker A motif; other site
1282356006788	ATP binding site [chemical binding]; other site
1282356006789	Walker B motif; other site
1282356006790	arginine finger; other site
1282356006791	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1282356006792	DNA-binding interface [nucleotide binding]; DNA binding site
1282356006793	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
1282356006794	FecR protein; Region: FecR; pfam04773
1282356006795	RNA polymerase sigma factor; Reviewed; Region: PRK12523
1282356006796	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1282356006797	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1282356006798	DNA binding residues [nucleotide binding]
1282356006799	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
1282356006800	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1282356006801	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1282356006802	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
1282356006803	Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402
1282356006804	glutathione S-transferase; Provisional; Region: PRK15113
1282356006805	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
1282356006806	C-terminal domain interface [polypeptide binding]; other site
1282356006807	GSH binding site (G-site) [chemical binding]; other site
1282356006808	dimer interface [polypeptide binding]; other site
1282356006809	C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195
1282356006810	putative dimer interface [polypeptide binding]; other site
1282356006811	N-terminal domain interface [polypeptide binding]; other site
1282356006812	putative substrate binding pocket (H-site) [chemical binding]; other site
1282356006813	Predicted membrane protein [Function unknown]; Region: COG3503
1282356006814	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
1282356006815	THF binding site; other site
1282356006816	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1282356006817	Cache domain; Region: Cache_1; pfam02743
1282356006818	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1282356006819	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1282356006820	metal binding site [ion binding]; metal-binding site
1282356006821	active site
1282356006822	I-site; other site
1282356006823	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
1282356006824	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1282356006825	active site
1282356006826	metal binding site [ion binding]; metal-binding site
1282356006827	hexamer interface [polypeptide binding]; other site
1282356006828	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1282356006829	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1282356006830	Walker A/P-loop; other site
1282356006831	ATP binding site [chemical binding]; other site
1282356006832	Q-loop/lid; other site
1282356006833	ABC transporter signature motif; other site
1282356006834	Walker B; other site
1282356006835	D-loop; other site
1282356006836	H-loop/switch region; other site
1282356006837	TOBE domain; Region: TOBE_2; pfam08402
1282356006838	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1282356006839	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356006840	dimer interface [polypeptide binding]; other site
1282356006841	conserved gate region; other site
1282356006842	putative PBP binding loops; other site
1282356006843	ABC-ATPase subunit interface; other site
1282356006844	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356006845	dimer interface [polypeptide binding]; other site
1282356006846	conserved gate region; other site
1282356006847	putative PBP binding loops; other site
1282356006848	ABC-ATPase subunit interface; other site
1282356006849	2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046
1282356006850	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1282356006851	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1282356006852	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1282356006853	DNA binding site [nucleotide binding]
1282356006854	Ligand-binding domain of putative DNA transcription repressors highly similar to that of the repressor specific for gluconate (GntR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_2; cd06282
1282356006855	putative ligand binding site [chemical binding]; other site
1282356006856	putative dimerization interface [polypeptide binding]; other site
1282356006857	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
1282356006858	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
1282356006859	dimer interface [polypeptide binding]; other site
1282356006860	active site
1282356006861	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1282356006862	catalytic residues [active]
1282356006863	substrate binding site [chemical binding]; other site
1282356006864	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
1282356006865	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
1282356006866	NAD(P) binding pocket [chemical binding]; other site
1282356006867	Bacterial transcriptional regulator; Region: IclR; pfam01614
1282356006868	glutaminase; Provisional; Region: PRK00971
1282356006869	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
1282356006870	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
1282356006871	B1 nucleotide binding pocket [chemical binding]; other site
1282356006872	B2 nucleotide binding pocket [chemical binding]; other site
1282356006873	CAS motifs; other site
1282356006874	active site
1282356006875	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1282356006876	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1282356006877	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1282356006878	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667
1282356006879	nudix motif; other site
1282356006880	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
1282356006881	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1282356006882	N-terminal plug; other site
1282356006883	ligand-binding site [chemical binding]; other site
1282356006884	Transposase domain (DUF772); Region: DUF772; pfam05598
1282356006885	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
1282356006886	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1282356006887	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
1282356006888	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1282356006889	Protein of unknown function (DUF2789); Region: DUF2789; pfam10982
1282356006890	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356006891	dimer interface [polypeptide binding]; other site
1282356006892	putative CheW interface [polypeptide binding]; other site
1282356006893	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
1282356006894	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
1282356006895	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1282356006896	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1282356006897	TM-ABC transporter signature motif; other site
1282356006898	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1282356006899	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1282356006900	Walker A/P-loop; other site
1282356006901	ATP binding site [chemical binding]; other site
1282356006902	Q-loop/lid; other site
1282356006903	ABC transporter signature motif; other site
1282356006904	Walker B; other site
1282356006905	D-loop; other site
1282356006906	H-loop/switch region; other site
1282356006907	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1282356006908	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1282356006909	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
1282356006910	putative ligand binding site [chemical binding]; other site
1282356006911	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1282356006912	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1282356006913	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1282356006914	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
1282356006915	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1282356006916	PYR/PP interface [polypeptide binding]; other site
1282356006917	dimer interface [polypeptide binding]; other site
1282356006918	TPP binding site [chemical binding]; other site
1282356006919	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1282356006920	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
1282356006921	TPP-binding site; other site
1282356006922	Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130
1282356006923	KduI/IolB family; Region: KduI; pfam04962
1282356006924	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1282356006925	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1282356006926	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1282356006927	substrate binding site [chemical binding]; other site
1282356006928	ATP binding site [chemical binding]; other site
1282356006929	Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863
1282356006930	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892
1282356006931	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1282356006932	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1282356006933	putative active site [active]
1282356006934	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1282356006935	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356006936	active site
1282356006937	phosphorylation site [posttranslational modification]
1282356006938	intermolecular recognition site; other site
1282356006939	dimerization interface [polypeptide binding]; other site
1282356006940	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1282356006941	DNA binding site [nucleotide binding]
1282356006942	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1282356006943	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1282356006944	dimerization interface [polypeptide binding]; other site
1282356006945	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356006946	dimer interface [polypeptide binding]; other site
1282356006947	phosphorylation site [posttranslational modification]
1282356006948	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356006949	ATP binding site [chemical binding]; other site
1282356006950	Mg2+ binding site [ion binding]; other site
1282356006951	G-X-G motif; other site
1282356006952	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
1282356006953	putative hydrophobic ligand binding site [chemical binding]; other site
1282356006954	protein interface [polypeptide binding]; other site
1282356006955	gate; other site
1282356006956	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1282356006957	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1282356006958	N-terminal plug; other site
1282356006959	ligand-binding site [chemical binding]; other site
1282356006960	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
1282356006961	putative inner membrane peptidase; Provisional; Region: PRK11778
1282356006962	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
1282356006963	tandem repeat interface [polypeptide binding]; other site
1282356006964	oligomer interface [polypeptide binding]; other site
1282356006965	active site residues [active]
1282356006966	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1282356006967	catalytic core [active]
1282356006968	SCP-2 sterol transfer family; Region: SCP2; pfam02036
1282356006969	3-oxoadipyl-CoA thiolase; Region: pcaF; TIGR02430
1282356006970	Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200
1282356006971	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
1282356006972	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
1282356006973	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1282356006974	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1282356006975	TPP-binding site [chemical binding]; other site
1282356006976	dimer interface [polypeptide binding]; other site
1282356006977	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1282356006978	PYR/PP interface [polypeptide binding]; other site
1282356006979	dimer interface [polypeptide binding]; other site
1282356006980	TPP binding site [chemical binding]; other site
1282356006981	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1282356006982	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1282356006983	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1282356006984	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1282356006985	AAA domain; Region: AAA_21; pfam13304
1282356006986	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1282356006987	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356006988	dimer interface [polypeptide binding]; other site
1282356006989	phosphorylation site [posttranslational modification]
1282356006990	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356006991	ATP binding site [chemical binding]; other site
1282356006992	G-X-G motif; other site
1282356006993	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1282356006994	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356006995	active site
1282356006996	phosphorylation site [posttranslational modification]
1282356006997	intermolecular recognition site; other site
1282356006998	dimerization interface [polypeptide binding]; other site
1282356006999	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
1282356007000	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
1282356007001	putative active site [active]
1282356007002	putative PHP Thumb interface [polypeptide binding]; other site
1282356007003	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1282356007004	generic binding surface I; other site
1282356007005	generic binding surface II; other site
1282356007006	DNA Polymerase Y-family; Region: PolY_like; cd03468
1282356007007	active site
1282356007008	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
1282356007009	DNA binding site [nucleotide binding]
1282356007010	Uncharacterized conserved protein [Function unknown]; Region: COG4544
1282356007011	LexA repressor; Provisional; Region: PRK12423
1282356007012	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
1282356007013	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1282356007014	Catalytic site [active]
1282356007015	Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101
1282356007016	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1282356007017	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
1282356007018	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1282356007019	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1282356007020	Walker A/P-loop; other site
1282356007021	ATP binding site [chemical binding]; other site
1282356007022	Q-loop/lid; other site
1282356007023	ABC transporter signature motif; other site
1282356007024	Walker B; other site
1282356007025	D-loop; other site
1282356007026	H-loop/switch region; other site
1282356007027	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
1282356007028	catalytic core [active]
1282356007029	4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279
1282356007030	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1282356007031	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1282356007032	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
1282356007033	Condensation domain; Region: Condensation; pfam00668
1282356007034	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1282356007035	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1282356007036	acyl-activating enzyme (AAE) consensus motif; other site
1282356007037	AMP binding site [chemical binding]; other site
1282356007038	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1282356007039	Condensation domain; Region: Condensation; pfam00668
1282356007040	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1282356007041	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1282356007042	acyl-activating enzyme (AAE) consensus motif; other site
1282356007043	AMP binding site [chemical binding]; other site
1282356007044	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1282356007045	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1282356007046	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1282356007047	DNA binding residues [nucleotide binding]
1282356007048	dimerization interface [polypeptide binding]; other site
1282356007049	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1282356007050	Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543
1282356007051	putative dimerization interface [polypeptide binding]; other site
1282356007052	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1282356007053	putative ligand binding site [chemical binding]; other site
1282356007054	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1282356007055	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1282356007056	xylose isomerase; Provisional; Region: PRK05474
1282356007057	xylose isomerase; Region: xylose_isom_A; TIGR02630
1282356007058	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
1282356007059	D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634
1282356007060	putative ligand binding site [chemical binding]; other site
1282356007061	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
1282356007062	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1282356007063	Walker A/P-loop; other site
1282356007064	ATP binding site [chemical binding]; other site
1282356007065	Q-loop/lid; other site
1282356007066	ABC transporter signature motif; other site
1282356007067	Walker B; other site
1282356007068	D-loop; other site
1282356007069	H-loop/switch region; other site
1282356007070	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1282356007071	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1282356007072	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1282356007073	TM-ABC transporter signature motif; other site
1282356007074	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1282356007075	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
1282356007076	putative ligand binding site [chemical binding]; other site
1282356007077	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1282356007078	dimerization interface [polypeptide binding]; other site
1282356007079	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1282356007080	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356007081	dimer interface [polypeptide binding]; other site
1282356007082	putative CheW interface [polypeptide binding]; other site
1282356007083	Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997
1282356007084	active site
1282356007085	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1282356007086	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
1282356007087	tetrameric interface [polypeptide binding]; other site
1282356007088	NAD binding site [chemical binding]; other site
1282356007089	catalytic residues [active]
1282356007090	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356007091	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356007092	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1282356007093	putative effector binding pocket; other site
1282356007094	dimerization interface [polypeptide binding]; other site
1282356007095	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1282356007096	non-specific DNA binding site [nucleotide binding]; other site
1282356007097	salt bridge; other site
1282356007098	sequence-specific DNA binding site [nucleotide binding]; other site
1282356007099	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1282356007100	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
1282356007101	putative dimer interface [polypeptide binding]; other site
1282356007102	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1282356007103	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1282356007104	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356007105	dimer interface [polypeptide binding]; other site
1282356007106	putative CheW interface [polypeptide binding]; other site
1282356007107	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
1282356007108	YccA-like proteins; Region: YccA_like; cd10433
1282356007109	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
1282356007110	FAD binding domain; Region: FAD_binding_4; pfam01565
1282356007111	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1282356007112	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1282356007113	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1282356007114	active site
1282356007115	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
1282356007116	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
1282356007117	Ligand binding site; other site
1282356007118	oligomer interface; other site
1282356007119	Uncharacterized conserved protein [Function unknown]; Region: COG2835
1282356007120	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
1282356007121	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
1282356007122	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1282356007123	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
1282356007124	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
1282356007125	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
1282356007126	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
1282356007127	Competence protein; Region: Competence; pfam03772
1282356007128	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1282356007129	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3216
1282356007130	hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107
1282356007131	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1282356007132	dimerization interface [polypeptide binding]; other site
1282356007133	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356007134	dimer interface [polypeptide binding]; other site
1282356007135	phosphorylation site [posttranslational modification]
1282356007136	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356007137	ATP binding site [chemical binding]; other site
1282356007138	Mg2+ binding site [ion binding]; other site
1282356007139	G-X-G motif; other site
1282356007140	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356007141	active site
1282356007142	phosphorylation site [posttranslational modification]
1282356007143	intermolecular recognition site; other site
1282356007144	dimerization interface [polypeptide binding]; other site
1282356007145	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1282356007146	putative binding surface; other site
1282356007147	active site
1282356007148	Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187
1282356007149	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1282356007150	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1282356007151	catalytic residues [active]
1282356007152	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
1282356007153	ArsC family; Region: ArsC; pfam03960
1282356007154	catalytic residues [active]
1282356007155	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1282356007156	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1282356007157	3-methyladenine DNA glycosylase [DNA replication, recombination, and repair]; Region: Tag; COG2818
1282356007158	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
1282356007159	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
1282356007160	Ligand Binding Site [chemical binding]; other site
1282356007161	hypothetical protein; Provisional; Region: PRK04860
1282356007162	SprT homologues; Region: SprT; cl01182
1282356007163	sulfur transfer complex subunit TusD; Validated; Region: PRK00207
1282356007164	sulfur relay protein TusC; Validated; Region: PRK00211
1282356007165	sulfur relay protein TusB/DsrH; Region: sulf_tusB_dsrH; TIGR03011
1282356007166	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
1282356007167	sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342
1282356007168	hypothetical protein; Validated; Region: PRK09071
1282356007169	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1282356007170	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
1282356007171	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
1282356007172	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
1282356007173	putative dimer interface [polypeptide binding]; other site
1282356007174	N-terminal domain interface [polypeptide binding]; other site
1282356007175	putative substrate binding pocket (H-site) [chemical binding]; other site
1282356007176	siroheme synthase; Provisional; Region: cysG; PRK10637
1282356007177	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
1282356007178	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
1282356007179	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1282356007180	active site
1282356007181	SAM binding site [chemical binding]; other site
1282356007182	homodimer interface [polypeptide binding]; other site
1282356007183	seryl-tRNA synthetase; Provisional; Region: PRK05431
1282356007184	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1282356007185	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1282356007186	dimer interface [polypeptide binding]; other site
1282356007187	active site
1282356007188	motif 1; other site
1282356007189	motif 2; other site
1282356007190	motif 3; other site
1282356007191	camphor resistance protein CrcB; Provisional; Region: PRK14234
1282356007192	recombination factor protein RarA; Reviewed; Region: PRK13342
1282356007193	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356007194	Walker A motif; other site
1282356007195	ATP binding site [chemical binding]; other site
1282356007196	Walker B motif; other site
1282356007197	arginine finger; other site
1282356007198	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1282356007199	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
1282356007200	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
1282356007201	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
1282356007202	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1282356007203	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1282356007204	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
1282356007205	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
1282356007206	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
1282356007207	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
1282356007208	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1282356007209	rRNA binding site [nucleotide binding]; other site
1282356007210	predicted 30S ribosome binding site; other site
1282356007211	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
1282356007212	Clp amino terminal domain; Region: Clp_N; pfam02861
1282356007213	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356007214	Walker A motif; other site
1282356007215	ATP binding site [chemical binding]; other site
1282356007216	Walker B motif; other site
1282356007217	arginine finger; other site
1282356007218	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356007219	Walker A motif; other site
1282356007220	ATP binding site [chemical binding]; other site
1282356007221	Walker B motif; other site
1282356007222	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1282356007223	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
1282356007224	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1282356007225	DNA-binding site [nucleotide binding]; DNA binding site
1282356007226	RNA-binding motif; other site
1282356007227	isocitrate dehydrogenase; Validated; Region: PRK07362
1282356007228	isocitrate dehydrogenase; Reviewed; Region: PRK07006
1282356007229	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
1282356007230	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
1282356007231	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
1282356007232	nudix motif; other site
1282356007233	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
1282356007234	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1282356007235	putative lysogenization regulator; Reviewed; Region: PRK00218
1282356007236	adenylosuccinate lyase; Provisional; Region: PRK09285
1282356007237	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
1282356007238	tetramer interface [polypeptide binding]; other site
1282356007239	active site
1282356007240	Uncharacterized conserved protein [Function unknown]; Region: COG2850
1282356007241	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1282356007242	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1282356007243	Coenzyme A binding pocket [chemical binding]; other site
1282356007244	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1282356007245	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1282356007246	isocitrate lyase; Provisional; Region: PRK15063
1282356007247	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1282356007248	tetramer interface [polypeptide binding]; other site
1282356007249	active site
1282356007250	Mg2+/Mn2+ binding site [ion binding]; other site
1282356007251	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
1282356007252	NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377
1282356007253	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
1282356007254	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
1282356007255	NADH dehydrogenase subunit D; Validated; Region: PRK06075
1282356007256	NADH dehydrogenase subunit E; Validated; Region: PRK07539
1282356007257	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
1282356007258	putative dimer interface [polypeptide binding]; other site
1282356007259	[2Fe-2S] cluster binding site [ion binding]; other site
1282356007260	NADH dehydrogenase I subunit F; Provisional; Region: PRK11278
1282356007261	SLBB domain; Region: SLBB; pfam10531
1282356007262	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
1282356007263	NADH dehydrogenase subunit G; Validated; Region: PRK08166
1282356007264	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1282356007265	catalytic loop [active]
1282356007266	iron binding site [ion binding]; other site
1282356007267	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1282356007268	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
1282356007269	[4Fe-4S] binding site [ion binding]; other site
1282356007270	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
1282356007271	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
1282356007272	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
1282356007273	4Fe-4S binding domain; Region: Fer4; pfam00037
1282356007274	4Fe-4S binding domain; Region: Fer4; pfam00037
1282356007275	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
1282356007276	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
1282356007277	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
1282356007278	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
1282356007279	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
1282356007280	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
1282356007281	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1282356007282	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
1282356007283	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1282356007284	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
1282356007285	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1282356007286	Protein of unknown function (DUF1044); Region: DUF1044; cl01955
1282356007287	Predicted transcriptional regulator [Transcription]; Region: COG2944
1282356007288	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356007289	putative substrate translocation pore; other site
1282356007290	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356007291	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
1282356007292	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1282356007293	tetrameric interface [polypeptide binding]; other site
1282356007294	activator binding site; other site
1282356007295	NADP binding site [chemical binding]; other site
1282356007296	substrate binding site [chemical binding]; other site
1282356007297	catalytic residues [active]
1282356007298	Predicted membrane protein [Function unknown]; Region: COG1289
1282356007299	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1282356007300	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1282356007301	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1282356007302	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1282356007303	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1282356007304	Walker A/P-loop; other site
1282356007305	ATP binding site [chemical binding]; other site
1282356007306	Q-loop/lid; other site
1282356007307	ABC transporter signature motif; other site
1282356007308	Walker B; other site
1282356007309	D-loop; other site
1282356007310	H-loop/switch region; other site
1282356007311	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1282356007312	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1282356007313	FtsX-like permease family; Region: FtsX; pfam02687
1282356007314	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
1282356007315	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1282356007316	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1282356007317	HlyD family secretion protein; Region: HlyD_3; pfam13437
1282356007318	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
1282356007319	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
1282356007320	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1282356007321	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1282356007322	active site
1282356007323	non-prolyl cis peptide bond; other site
1282356007324	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1282356007325	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1282356007326	active site
1282356007327	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
1282356007328	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
1282356007329	Flavin binding site [chemical binding]; other site
1282356007330	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1282356007331	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1282356007332	non-specific DNA binding site [nucleotide binding]; other site
1282356007333	salt bridge; other site
1282356007334	sequence-specific DNA binding site [nucleotide binding]; other site
1282356007335	Cupin domain; Region: Cupin_2; pfam07883
1282356007336	EamA-like transporter family; Region: EamA; pfam00892
1282356007337	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1282356007338	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
1282356007339	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
1282356007340	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1282356007341	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
1282356007342	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
1282356007343	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094
1282356007344	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
1282356007345	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1282356007346	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
1282356007347	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161
1282356007348	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583
1282356007349	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1282356007350	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1282356007351	active site
1282356007352	HIGH motif; other site
1282356007353	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1282356007354	KMSKS motif; other site
1282356007355	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
1282356007356	tRNA binding surface [nucleotide binding]; other site
1282356007357	anticodon binding site; other site
1282356007358	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
1282356007359	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1282356007360	active site
1282356007361	HIGH motif; other site
1282356007362	nucleotide binding site [chemical binding]; other site
1282356007363	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
1282356007364	KMSKS motif; other site
1282356007365	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
1282356007366	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
1282356007367	substrate binding site [chemical binding]; other site
1282356007368	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1282356007369	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
1282356007370	putative active site [active]
1282356007371	putative metal binding site [ion binding]; other site
1282356007372	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1282356007373	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356007374	putative substrate translocation pore; other site
1282356007375	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356007376	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
1282356007377	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1282356007378	HlyD family secretion protein; Region: HlyD_3; pfam13437
1282356007379	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1282356007380	MarR family; Region: MarR_2; cl17246
1282356007381	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1282356007382	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
1282356007383	Family of unknown function (DUF490); Region: DUF490; pfam04357
1282356007384	Family of unknown function (DUF490); Region: DUF490; pfam04357
1282356007385	Family of unknown function (DUF490); Region: DUF490; pfam04357
1282356007386	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
1282356007387	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1282356007388	Surface antigen; Region: Bac_surface_Ag; pfam01103
1282356007389	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
1282356007390	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
1282356007391	putative catalytic site [active]
1282356007392	putative phosphate binding site [ion binding]; other site
1282356007393	active site
1282356007394	metal binding site A [ion binding]; metal-binding site
1282356007395	DNA binding site [nucleotide binding]
1282356007396	putative AP binding site [nucleotide binding]; other site
1282356007397	putative metal binding site B [ion binding]; other site
1282356007398	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
1282356007399	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1282356007400	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1282356007401	ligand binding site [chemical binding]; other site
1282356007402	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1282356007403	Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155
1282356007404	FAD binding site [chemical binding]; other site
1282356007405	substrate binding site [chemical binding]; other site
1282356007406	catalytic base [active]
1282356007407	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
1282356007408	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356007409	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
1282356007410	substrate binding pocket [chemical binding]; other site
1282356007411	dimerization interface [polypeptide binding]; other site
1282356007412	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
1282356007413	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1282356007414	DNA binding residues [nucleotide binding]
1282356007415	putative dimer interface [polypeptide binding]; other site
1282356007416	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
1282356007417	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
1282356007418	active site
1282356007419	catalytic residues [active]
1282356007420	metal binding site [ion binding]; metal-binding site
1282356007421	AMP-binding domain protein; Validated; Region: PRK08315
1282356007422	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1282356007423	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
1282356007424	acyl-activating enzyme (AAE) consensus motif; other site
1282356007425	putative AMP binding site [chemical binding]; other site
1282356007426	putative active site [active]
1282356007427	putative CoA binding site [chemical binding]; other site
1282356007428	isovaleryl-CoA dehydrogenase; Region: PLN02519
1282356007429	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
1282356007430	substrate binding site [chemical binding]; other site
1282356007431	FAD binding site [chemical binding]; other site
1282356007432	catalytic base [active]
1282356007433	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
1282356007434	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1282356007435	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1282356007436	gamma-carboxygeranoyl-CoA hydratase; Validated; Region: PRK05674
1282356007437	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1282356007438	substrate binding site [chemical binding]; other site
1282356007439	oxyanion hole (OAH) forming residues; other site
1282356007440	trimer interface [polypeptide binding]; other site
1282356007441	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
1282356007442	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1282356007443	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1282356007444	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1282356007445	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1282356007446	carboxyltransferase (CT) interaction site; other site
1282356007447	biotinylation site [posttranslational modification]; other site
1282356007448	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1282356007449	salt bridge; other site
1282356007450	non-specific DNA binding site [nucleotide binding]; other site
1282356007451	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
1282356007452	sequence-specific DNA binding site [nucleotide binding]; other site
1282356007453	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1282356007454	Catalytic site [active]
1282356007455	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
1282356007456	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
1282356007457	active site
1282356007458	Zn binding site [ion binding]; other site
1282356007459	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
1282356007460	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
1282356007461	putative heme binding pocket [chemical binding]; other site
1282356007462	RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950
1282356007463	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1282356007464	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1282356007465	DNA binding residues [nucleotide binding]
1282356007466	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
1282356007467	Spore Coat Protein U domain; Region: SCPU; pfam05229
1282356007468	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
1282356007469	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
1282356007470	PapC C-terminal domain; Region: PapC_C; pfam13953
1282356007471	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
1282356007472	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1282356007473	Spore Coat Protein U domain; Region: SCPU; pfam05229
1282356007474	Spore Coat Protein U domain; Region: SCPU; pfam05229
1282356007475	Spore Coat Protein U domain; Region: SCPU; pfam05229
1282356007476	Spore Coat Protein U domain; Region: SCPU; pfam05229
1282356007477	AFG1-like ATPase; Region: AFG1_ATPase; pfam03969
1282356007478	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1282356007479	Walker A motif; other site
1282356007480	ATP binding site [chemical binding]; other site
1282356007481	Walker B motif; other site
1282356007482	arginine finger; other site
1282356007483	Leucine rich repeat; Region: LRR_8; pfam13855
1282356007484	Leucine rich repeat; Region: LRR_8; pfam13855
1282356007485	Protein kinase domain; Region: Pkinase; pfam00069
1282356007486	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1282356007487	active site
1282356007488	ATP binding site [chemical binding]; other site
1282356007489	substrate binding site [chemical binding]; other site
1282356007490	activation loop (A-loop); other site
1282356007491	hypothetical protein; Provisional; Region: PRK12378
1282356007492	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356007493	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
1282356007494	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1282356007495	dimerization interface [polypeptide binding]; other site
1282356007496	2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479
1282356007497	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1282356007498	catalytic residue [active]
1282356007499	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
1282356007500	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1282356007501	motif II; other site
1282356007502	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
1282356007503	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
1282356007504	catalytic residue [active]
1282356007505	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
1282356007506	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1282356007507	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
1282356007508	active site
1282356007509	FMN binding site [chemical binding]; other site
1282356007510	2,4-decadienoyl-CoA binding site; other site
1282356007511	catalytic residue [active]
1282356007512	4Fe-4S cluster binding site [ion binding]; other site
1282356007513	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
1282356007514	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1282356007515	metal binding site [ion binding]; metal-binding site
1282356007516	active site
1282356007517	I-site; other site
1282356007518	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1282356007519	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1282356007520	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
1282356007521	active site
1282356007522	catalytic triad [active]
1282356007523	dimer interface [polypeptide binding]; other site
1282356007524	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1282356007525	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1282356007526	Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001
1282356007527	periplasmic folding chaperone; Provisional; Region: PRK10788
1282356007528	SurA N-terminal domain; Region: SurA_N_3; pfam13624
1282356007529	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1282356007530	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1282356007531	IHF - DNA interface [nucleotide binding]; other site
1282356007532	IHF dimer interface [polypeptide binding]; other site
1282356007533	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
1282356007534	Found in ATP-dependent protease La (LON); Region: LON; smart00464
1282356007535	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356007536	Walker A motif; other site
1282356007537	ATP binding site [chemical binding]; other site
1282356007538	Walker B motif; other site
1282356007539	arginine finger; other site
1282356007540	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1282356007541	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1282356007542	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1282356007543	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356007544	Walker A motif; other site
1282356007545	ATP binding site [chemical binding]; other site
1282356007546	Walker B motif; other site
1282356007547	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1282356007548	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
1282356007549	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1282356007550	oligomer interface [polypeptide binding]; other site
1282356007551	active site residues [active]
1282356007552	trigger factor; Provisional; Region: tig; PRK01490
1282356007553	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1282356007554	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1282356007555	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
1282356007556	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1282356007557	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1282356007558	homodimer interface [polypeptide binding]; other site
1282356007559	NADP binding site [chemical binding]; other site
1282356007560	substrate binding site [chemical binding]; other site
1282356007561	D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669
1282356007562	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1282356007563	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
1282356007564	putative active site [active]
1282356007565	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1282356007566	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1282356007567	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1282356007568	E3 interaction surface; other site
1282356007569	lipoyl attachment site [posttranslational modification]; other site
1282356007570	HlyD family secretion protein; Region: HlyD_3; pfam13437
1282356007571	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1282356007572	CopC domain; Region: CopC; pfam04234
1282356007573	Copper resistance protein D; Region: CopD; cl00563
1282356007574	outer membrane porin, OprD family; Region: OprD; pfam03573
1282356007575	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1282356007576	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1282356007577	NAD(P) binding site [chemical binding]; other site
1282356007578	active site
1282356007579	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1282356007580	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1282356007581	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
1282356007582	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
1282356007583	DctM-like transporters; Region: DctM; pfam06808
1282356007584	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
1282356007585	aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021
1282356007586	active site
1282356007587	catalytic residues [active]
1282356007588	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1282356007589	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1282356007590	HlyD family secretion protein; Region: HlyD_3; pfam13437
1282356007591	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356007592	putative substrate translocation pore; other site
1282356007593	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1282356007594	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
1282356007595	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1282356007596	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1282356007597	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1282356007598	putative DNA binding site [nucleotide binding]; other site
1282356007599	putative Zn2+ binding site [ion binding]; other site
1282356007600	AsnC family; Region: AsnC_trans_reg; pfam01037
1282356007601	2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573
1282356007602	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
1282356007603	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1282356007604	tetramer interface [polypeptide binding]; other site
1282356007605	TPP-binding site [chemical binding]; other site
1282356007606	heterodimer interface [polypeptide binding]; other site
1282356007607	phosphorylation loop region [posttranslational modification]
1282356007608	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1282356007609	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1282356007610	alpha subunit interface [polypeptide binding]; other site
1282356007611	TPP binding site [chemical binding]; other site
1282356007612	heterodimer interface [polypeptide binding]; other site
1282356007613	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1282356007614	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1282356007615	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1282356007616	E3 interaction surface; other site
1282356007617	lipoyl attachment site [posttranslational modification]; other site
1282356007618	e3 binding domain; Region: E3_binding; pfam02817
1282356007619	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1282356007620	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
1282356007621	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1282356007622	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1282356007623	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
1282356007624	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1282356007625	homodimer interface [polypeptide binding]; other site
1282356007626	substrate-cofactor binding pocket; other site
1282356007627	catalytic residue [active]
1282356007628	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
1282356007629	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1282356007630	putative acetyltransferase; Provisional; Region: PRK03624
1282356007631	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1282356007632	Coenzyme A binding pocket [chemical binding]; other site
1282356007633	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
1282356007634	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
1282356007635	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1282356007636	FeS/SAM binding site; other site
1282356007637	L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434
1282356007638	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1282356007639	RNA polymerase sigma factor; Reviewed; Region: PRK12527
1282356007640	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1282356007641	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1282356007642	DNA binding residues [nucleotide binding]
1282356007643	macrolide transporter subunit MacA; Provisional; Region: PRK11578
1282356007644	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1282356007645	HlyD family secretion protein; Region: HlyD_3; pfam13437
1282356007646	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
1282356007647	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1282356007648	Walker A/P-loop; other site
1282356007649	ATP binding site [chemical binding]; other site
1282356007650	Q-loop/lid; other site
1282356007651	ABC transporter signature motif; other site
1282356007652	Walker B; other site
1282356007653	D-loop; other site
1282356007654	H-loop/switch region; other site
1282356007655	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1282356007656	FtsX-like permease family; Region: FtsX; pfam02687
1282356007657	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
1282356007658	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
1282356007659	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356007660	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356007661	LysR substrate binding domain; Region: LysR_substrate; pfam03466
1282356007662	dimerization interface [polypeptide binding]; other site
1282356007663	Secretin and TonB N terminus short domain; Region: STN; smart00965
1282356007664	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1282356007665	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1282356007666	N-terminal plug; other site
1282356007667	ligand-binding site [chemical binding]; other site
1282356007668	VirK protein; Region: VirK; pfam06903
1282356007669	Cupin domain; Region: Cupin_2; cl17218
1282356007670	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
1282356007671	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1282356007672	DNA binding residues [nucleotide binding]
1282356007673	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1282356007674	IHF dimer interface [polypeptide binding]; other site
1282356007675	IHF - DNA interface [nucleotide binding]; other site
1282356007676	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1282356007677	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1282356007678	putative tRNA-binding site [nucleotide binding]; other site
1282356007679	B3/4 domain; Region: B3_4; pfam03483
1282356007680	tRNA synthetase B5 domain; Region: B5; pfam03484
1282356007681	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1282356007682	dimer interface [polypeptide binding]; other site
1282356007683	motif 1; other site
1282356007684	motif 3; other site
1282356007685	motif 2; other site
1282356007686	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1282356007687	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1282356007688	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1282356007689	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1282356007690	dimer interface [polypeptide binding]; other site
1282356007691	motif 1; other site
1282356007692	active site
1282356007693	motif 2; other site
1282356007694	motif 3; other site
1282356007695	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1282356007696	23S rRNA binding site [nucleotide binding]; other site
1282356007697	L21 binding site [polypeptide binding]; other site
1282356007698	L13 binding site [polypeptide binding]; other site
1282356007699	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1282356007700	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1282356007701	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1282356007702	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1282356007703	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1282356007704	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1282356007705	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
1282356007706	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1282356007707	active site
1282356007708	dimer interface [polypeptide binding]; other site
1282356007709	motif 1; other site
1282356007710	motif 2; other site
1282356007711	motif 3; other site
1282356007712	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1282356007713	anticodon binding site; other site
1282356007714	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1282356007715	DNA-binding site [nucleotide binding]; DNA binding site
1282356007716	RNA-binding motif; other site
1282356007717	Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720
1282356007718	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
1282356007719	active site
1282356007720	tetramer interface [polypeptide binding]; other site
1282356007721	D-ribose pyranase; Provisional; Region: PRK11797
1282356007722	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1282356007723	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1282356007724	substrate binding site [chemical binding]; other site
1282356007725	dimer interface [polypeptide binding]; other site
1282356007726	ATP binding site [chemical binding]; other site
1282356007727	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1282356007728	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1282356007729	DNA binding site [nucleotide binding]
1282356007730	domain linker motif; other site
1282356007731	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1282356007732	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1282356007733	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1282356007734	TM-ABC transporter signature motif; other site
1282356007735	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1282356007736	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1282356007737	Walker A/P-loop; other site
1282356007738	ATP binding site [chemical binding]; other site
1282356007739	Q-loop/lid; other site
1282356007740	ABC transporter signature motif; other site
1282356007741	Walker B; other site
1282356007742	D-loop; other site
1282356007743	H-loop/switch region; other site
1282356007744	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1282356007745	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
1282356007746	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1282356007747	ligand binding site [chemical binding]; other site
1282356007748	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411
1282356007749	homodimer interface [polypeptide binding]; other site
1282356007750	active site
1282356007751	Protein of unknown function (DUF1654); Region: DUF1654; pfam07867
1282356007752	DNA-specific endonuclease I; Provisional; Region: PRK15137
1282356007753	Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356
1282356007754	carbon storage regulator; Provisional; Region: PRK01712
1282356007755	putative phosphatase; Provisional; Region: PRK11587
1282356007756	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1282356007757	active site
1282356007758	motif I; other site
1282356007759	motif II; other site
1282356007760	Protein of unknown function (DUF2790); Region: DUF2790; pfam10976
1282356007761	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
1282356007762	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356007763	active site
1282356007764	phosphorylation site [posttranslational modification]
1282356007765	intermolecular recognition site; other site
1282356007766	dimerization interface [polypeptide binding]; other site
1282356007767	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1282356007768	DNA binding site [nucleotide binding]
1282356007769	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
1282356007770	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1282356007771	dimerization interface [polypeptide binding]; other site
1282356007772	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356007773	dimer interface [polypeptide binding]; other site
1282356007774	phosphorylation site [posttranslational modification]
1282356007775	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356007776	ATP binding site [chemical binding]; other site
1282356007777	G-X-G motif; other site
1282356007778	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1282356007779	Coenzyme A binding pocket [chemical binding]; other site
1282356007780	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1282356007781	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1282356007782	oxidoreductase; Validated; Region: PRK05717
1282356007783	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1282356007784	NAD(P) binding site [chemical binding]; other site
1282356007785	active site
1282356007786	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
1282356007787	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1282356007788	homodimer interface [polypeptide binding]; other site
1282356007789	substrate-cofactor binding pocket; other site
1282356007790	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356007791	catalytic residue [active]
1282356007792	amidophosphoribosyltransferase; Provisional; Region: PRK09246
1282356007793	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1282356007794	active site
1282356007795	tetramer interface [polypeptide binding]; other site
1282356007796	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1282356007797	active site
1282356007798	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
1282356007799	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
1282356007800	Colicin V production protein; Region: Colicin_V; cl00567
1282356007801	Sporulation related domain; Region: SPOR; pfam05036
1282356007802	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
1282356007803	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1282356007804	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1282356007805	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
1282356007806	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1282356007807	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
1282356007808	active site
1282356007809	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1282356007810	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1282356007811	dimerization interface 3.5A [polypeptide binding]; other site
1282356007812	active site
1282356007813	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1282356007814	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1282356007815	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
1282356007816	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK05671
1282356007817	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1282356007818	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
1282356007819	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1282356007820	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
1282356007821	tartrate dehydrogenase; Region: TTC; TIGR02089
1282356007822	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1282356007823	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356007824	S-adenosylmethionine binding site [chemical binding]; other site
1282356007825	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1282356007826	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1282356007827	substrate binding site [chemical binding]; other site
1282356007828	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1282356007829	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1282356007830	substrate binding site [chemical binding]; other site
1282356007831	ligand binding site [chemical binding]; other site
1282356007832	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356007833	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356007834	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1282356007835	dimerization interface [polypeptide binding]; other site
1282356007836	PAS fold; Region: PAS_3; pfam08447
1282356007837	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
1282356007838	PAS domain S-box; Region: sensory_box; TIGR00229
1282356007839	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356007840	putative active site [active]
1282356007841	heme pocket [chemical binding]; other site
1282356007842	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1282356007843	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1282356007844	metal binding site [ion binding]; metal-binding site
1282356007845	active site
1282356007846	I-site; other site
1282356007847	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1282356007848	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
1282356007849	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1282356007850	FMN binding site [chemical binding]; other site
1282356007851	active site
1282356007852	catalytic residues [active]
1282356007853	substrate binding site [chemical binding]; other site
1282356007854	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1282356007855	active site
1282356007856	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1282356007857	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1282356007858	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1282356007859	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1282356007860	active site
1282356007861	HIGH motif; other site
1282356007862	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1282356007863	active site
1282356007864	KMSKS motif; other site
1282356007865	excinuclease ABC subunit B; Provisional; Region: PRK05298
1282356007866	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1282356007867	ATP binding site [chemical binding]; other site
1282356007868	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1282356007869	nucleotide binding region [chemical binding]; other site
1282356007870	ATP-binding site [chemical binding]; other site
1282356007871	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1282356007872	UvrB/uvrC motif; Region: UVR; pfam02151
1282356007873	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
1282356007874	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1282356007875	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356007876	homodimer interface [polypeptide binding]; other site
1282356007877	catalytic residue [active]
1282356007878	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356007879	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356007880	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
1282356007881	putative dimerization interface [polypeptide binding]; other site
1282356007882	putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968
1282356007883	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
1282356007884	NAD(P) binding site [chemical binding]; other site
1282356007885	catalytic residues [active]
1282356007886	aminopeptidase B; Provisional; Region: PRK05015
1282356007887	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
1282356007888	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
1282356007889	active site
1282356007890	Zn binding site [ion binding]; other site
1282356007891	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
1282356007892	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
1282356007893	active site
1282356007894	substrate binding site [chemical binding]; other site
1282356007895	Mg2+ binding site [ion binding]; other site
1282356007896	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
1282356007897	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
1282356007898	putative ligand binding residues [chemical binding]; other site
1282356007899	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1282356007900	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1282356007901	ABC-ATPase subunit  interface; other site
1282356007902	dimer interface [polypeptide binding]; other site
1282356007903	putative PBP binding regions; other site
1282356007904	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1282356007905	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1282356007906	Walker A/P-loop; other site
1282356007907	ATP binding site [chemical binding]; other site
1282356007908	Q-loop/lid; other site
1282356007909	ABC transporter signature motif; other site
1282356007910	Walker B; other site
1282356007911	D-loop; other site
1282356007912	H-loop/switch region; other site
1282356007913	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1282356007914	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356007915	dimer interface [polypeptide binding]; other site
1282356007916	phosphorylation site [posttranslational modification]
1282356007917	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356007918	ATP binding site [chemical binding]; other site
1282356007919	Mg2+ binding site [ion binding]; other site
1282356007920	G-X-G motif; other site
1282356007921	Response regulator receiver domain; Region: Response_reg; pfam00072
1282356007922	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356007923	active site
1282356007924	phosphorylation site [posttranslational modification]
1282356007925	intermolecular recognition site; other site
1282356007926	dimerization interface [polypeptide binding]; other site
1282356007927	PAS domain S-box; Region: sensory_box; TIGR00229
1282356007928	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356007929	heme pocket [chemical binding]; other site
1282356007930	putative active site [active]
1282356007931	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356007932	dimer interface [polypeptide binding]; other site
1282356007933	phosphorylation site [posttranslational modification]
1282356007934	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356007935	ATP binding site [chemical binding]; other site
1282356007936	Mg2+ binding site [ion binding]; other site
1282356007937	G-X-G motif; other site
1282356007938	Response regulator receiver domain; Region: Response_reg; pfam00072
1282356007939	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356007940	active site
1282356007941	phosphorylation site [posttranslational modification]
1282356007942	intermolecular recognition site; other site
1282356007943	dimerization interface [polypeptide binding]; other site
1282356007944	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1282356007945	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1282356007946	TspO/MBR family; Region: TspO_MBR; pfam03073
1282356007947	topology modulation protein; Reviewed; Region: PRK08118
1282356007948	AAA domain; Region: AAA_17; pfam13207
1282356007949	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
1282356007950	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356007951	putative substrate translocation pore; other site
1282356007952	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1282356007953	nudix motif; other site
1282356007954	Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042
1282356007955	Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023
1282356007956	active site
1282356007957	catalytic residues [active]
1282356007958	T5orf172 domain; Region: T5orf172; pfam10544
1282356007959	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281
1282356007960	Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cl02025
1282356007961	substrate binding site [chemical binding]; other site
1282356007962	B12 cofactor binding site [chemical binding]; other site
1282356007963	heterodimer (sigma-epsilon) interface [polypeptide binding]; other site
1282356007964	homodimer (epsilon-epsilon) interface [polypeptide binding]; other site
1282356007965	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
1282356007966	B12 binding site [chemical binding]; other site
1282356007967	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
1282356007968	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1282356007969	putative di-iron ligands [ion binding]; other site
1282356007970	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356007971	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356007972	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1282356007973	dimerization interface [polypeptide binding]; other site
1282356007974	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
1282356007975	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
1282356007976	NADP binding site [chemical binding]; other site
1282356007977	dimer interface [polypeptide binding]; other site
1282356007978	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1282356007979	methionine sulfoxide reductase A; Provisional; Region: PRK14054
1282356007980	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356007981	PAS fold; Region: PAS_3; pfam08447
1282356007982	putative active site [active]
1282356007983	heme pocket [chemical binding]; other site
1282356007984	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356007985	PAS fold; Region: PAS_3; pfam08447
1282356007986	putative active site [active]
1282356007987	heme pocket [chemical binding]; other site
1282356007988	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356007989	putative CheW interface [polypeptide binding]; other site
1282356007990	CHASE3 domain; Region: CHASE3; pfam05227
1282356007991	HAMP domain; Region: HAMP; pfam00672
1282356007992	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1282356007993	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356007994	dimer interface [polypeptide binding]; other site
1282356007995	putative CheW interface [polypeptide binding]; other site
1282356007996	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
1282356007997	active site
1282356007998	catalytic residues [active]
1282356007999	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1282356008000	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
1282356008001	conserved cys residue [active]
1282356008002	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
1282356008003	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144
1282356008004	conserved cys residue [active]
1282356008005	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1282356008006	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
1282356008007	putative C-terminal domain interface [polypeptide binding]; other site
1282356008008	putative GSH binding site (G-site) [chemical binding]; other site
1282356008009	putative dimer interface [polypeptide binding]; other site
1282356008010	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
1282356008011	putative N-terminal domain interface [polypeptide binding]; other site
1282356008012	putative dimer interface [polypeptide binding]; other site
1282356008013	putative substrate binding pocket (H-site) [chemical binding]; other site
1282356008014	OPT oligopeptide transporter protein; Region: OPT; pfam03169
1282356008015	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356008016	dimer interface [polypeptide binding]; other site
1282356008017	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
1282356008018	putative CheW interface [polypeptide binding]; other site
1282356008019	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
1282356008020	Family of unknown function (DUF633); Region: DUF633; pfam04816
1282356008021	Sulphur transport; Region: Sulf_transp; pfam04143
1282356008022	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
1282356008023	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
1282356008024	active site
1282356008025	substrate binding site [chemical binding]; other site
1282356008026	Mg2+ binding site [ion binding]; other site
1282356008027	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356008028	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356008029	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
1282356008030	putative dimerization interface [polypeptide binding]; other site
1282356008031	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
1282356008032	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
1282356008033	active site
1282356008034	substrate binding site [chemical binding]; other site
1282356008035	FMN binding site [chemical binding]; other site
1282356008036	putative catalytic residues [active]
1282356008037	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1282356008038	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1282356008039	metal binding site [ion binding]; metal-binding site
1282356008040	active site
1282356008041	I-site; other site
1282356008042	Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424
1282356008043	PAS domain S-box; Region: sensory_box; TIGR00229
1282356008044	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356008045	putative active site [active]
1282356008046	heme pocket [chemical binding]; other site
1282356008047	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1282356008048	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1282356008049	metal binding site [ion binding]; metal-binding site
1282356008050	active site
1282356008051	I-site; other site
1282356008052	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1282356008053	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1282356008054	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1282356008055	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1282356008056	Walker A/P-loop; other site
1282356008057	ATP binding site [chemical binding]; other site
1282356008058	Q-loop/lid; other site
1282356008059	ABC transporter signature motif; other site
1282356008060	Walker B; other site
1282356008061	D-loop; other site
1282356008062	H-loop/switch region; other site
1282356008063	Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
1282356008064	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
1282356008065	catalytic residues [active]
1282356008066	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
1282356008067	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
1282356008068	active site residue [active]
1282356008069	Salmonella virulence plasmid 28.1kDa A protein; Region: VRP1; pfam03538
1282356008070	Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534
1282356008071	Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256
1282356008072	Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255
1282356008073	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
1282356008074	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
1282356008075	BolA-like protein; Region: BolA; pfam01722
1282356008076	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243
1282356008077	fumarate hydratase; Provisional; Region: PRK12425
1282356008078	Class II fumarases; Region: Fumarase_classII; cd01362
1282356008079	active site
1282356008080	tetramer interface [polypeptide binding]; other site
1282356008081	EamA-like transporter family; Region: EamA; cl17759
1282356008082	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
1282356008083	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1282356008084	dimer interface [polypeptide binding]; other site
1282356008085	active site
1282356008086	polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708
1282356008087	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
1282356008088	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
1282356008089	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
1282356008090	Uncharacterized conserved protein [Function unknown]; Region: COG4121
1282356008091	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
1282356008092	Leucine rich repeat; Region: LRR_8; pfam13855
1282356008093	asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104
1282356008094	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1282356008095	active site
1282356008096	dimer interface [polypeptide binding]; other site
1282356008097	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1282356008098	Ligand Binding Site [chemical binding]; other site
1282356008099	Molecular Tunnel; other site
1282356008100	GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT
1282356008101	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1282356008102	Coenzyme A binding pocket [chemical binding]; other site
1282356008103	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1282356008104	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1282356008105	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
1282356008106	putative oligomer interface [polypeptide binding]; other site
1282356008107	putative active site [active]
1282356008108	metal binding site [ion binding]; metal-binding site
1282356008109	hypothetical protein; Provisional; Region: PRK00304
1282356008110	Global regulator protein family; Region: CsrA; pfam02599
1282356008111	short chain dehydrogenase; Provisional; Region: PRK05650
1282356008112	classical (c) SDRs; Region: SDR_c; cd05233
1282356008113	NAD(P) binding site [chemical binding]; other site
1282356008114	active site
1282356008115	Protein of unknown function (DUF3309); Region: DUF3309; pfam11752
1282356008116	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1282356008117	Sulfatase; Region: Sulfatase; pfam00884
1282356008118	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
1282356008119	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1282356008120	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1282356008121	Protein of unknown function (DUF3509); Region: DUF3509; pfam12021
1282356008122	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1282356008123	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1282356008124	DNA binding residues [nucleotide binding]
1282356008125	dimerization interface [polypeptide binding]; other site
1282356008126	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
1282356008127	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356008128	putative substrate translocation pore; other site
1282356008129	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1282356008130	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1282356008131	Tetramer interface [polypeptide binding]; other site
1282356008132	active site
1282356008133	FMN-binding site [chemical binding]; other site
1282356008134	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
1282356008135	HemK family putative methylases; Region: hemK_fam; TIGR00536
1282356008136	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356008137	S-adenosylmethionine binding site [chemical binding]; other site
1282356008138	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
1282356008139	Isochorismatase family; Region: Isochorismatase; pfam00857
1282356008140	catalytic triad [active]
1282356008141	conserved cis-peptide bond; other site
1282356008142	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
1282356008143	Smr domain; Region: Smr; pfam01713
1282356008144	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
1282356008145	homodecamer interface [polypeptide binding]; other site
1282356008146	GTP cyclohydrolase I; Provisional; Region: PLN03044
1282356008147	active site
1282356008148	putative catalytic site residues [active]
1282356008149	zinc binding site [ion binding]; other site
1282356008150	GTP-CH-I/GFRP interaction surface; other site
1282356008151	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1282356008152	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
1282356008153	C-terminal domain interface [polypeptide binding]; other site
1282356008154	GSH binding site (G-site) [chemical binding]; other site
1282356008155	dimer interface [polypeptide binding]; other site
1282356008156	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
1282356008157	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
1282356008158	Citrate transporter; Region: CitMHS; pfam03600
1282356008159	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356008160	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356008161	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
1282356008162	putative dimerization interface [polypeptide binding]; other site
1282356008163	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1282356008164	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
1282356008165	putative C-terminal domain interface [polypeptide binding]; other site
1282356008166	putative GSH binding site (G-site) [chemical binding]; other site
1282356008167	putative dimer interface [polypeptide binding]; other site
1282356008168	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1282356008169	N-terminal domain interface [polypeptide binding]; other site
1282356008170	dimer interface [polypeptide binding]; other site
1282356008171	substrate binding pocket (H-site) [chemical binding]; other site
1282356008172	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1282356008173	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1282356008174	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
1282356008175	active site
1282356008176	homotetramer interface [polypeptide binding]; other site
1282356008177	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
1282356008178	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
1282356008179	active site
1282356008180	catalytic site [active]
1282356008181	tetramer interface [polypeptide binding]; other site
1282356008182	OHCU decarboxylase; Region: UHCUDC; TIGR03164
1282356008183	allantoicase; Provisional; Region: PRK13257
1282356008184	Allantoicase repeat; Region: Allantoicase; pfam03561
1282356008185	Allantoicase repeat; Region: Allantoicase; pfam03561
1282356008186	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
1282356008187	ureidoglycolate hydrolase; Provisional; Region: PRK03606
1282356008188	Predicted membrane protein [Function unknown]; Region: COG3748
1282356008189	Protein of unknown function (DUF989); Region: DUF989; pfam06181
1282356008190	Cytochrome c; Region: Cytochrom_C; pfam00034
1282356008191	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114
1282356008192	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1282356008193	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
1282356008194	active site
1282356008195	nucleophile elbow; other site
1282356008196	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1282356008197	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1282356008198	putative acyl-acceptor binding pocket; other site
1282356008199	septum formation inhibitor; Reviewed; Region: minC; PRK00339
1282356008200	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
1282356008201	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
1282356008202	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
1282356008203	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
1282356008204	Switch I; other site
1282356008205	Switch II; other site
1282356008206	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
1282356008207	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1282356008208	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1282356008209	active site
1282356008210	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
1282356008211	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
1282356008212	active site
1282356008213	metal binding site [ion binding]; metal-binding site
1282356008214	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1282356008215	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1282356008216	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251
1282356008217	diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938
1282356008218	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1282356008219	inhibitor-cofactor binding pocket; inhibition site
1282356008220	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356008221	catalytic residue [active]
1282356008222	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
1282356008223	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1282356008224	amidase catalytic site [active]
1282356008225	Zn binding residues [ion binding]; other site
1282356008226	substrate binding site [chemical binding]; other site
1282356008227	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
1282356008228	sensor protein QseC; Provisional; Region: PRK10337
1282356008229	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356008230	dimer interface [polypeptide binding]; other site
1282356008231	phosphorylation site [posttranslational modification]
1282356008232	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356008233	ATP binding site [chemical binding]; other site
1282356008234	G-X-G motif; other site
1282356008235	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
1282356008236	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356008237	active site
1282356008238	phosphorylation site [posttranslational modification]
1282356008239	intermolecular recognition site; other site
1282356008240	dimerization interface [polypeptide binding]; other site
1282356008241	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1282356008242	DNA binding site [nucleotide binding]
1282356008243	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
1282356008244	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
1282356008245	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
1282356008246	DsbD alpha interface [polypeptide binding]; other site
1282356008247	catalytic residues [active]
1282356008248	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
1282356008249	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1282356008250	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1282356008251	catalytic residues [active]
1282356008252	disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657
1282356008253	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
1282356008254	dimerization domain [polypeptide binding]; other site
1282356008255	dimer interface [polypeptide binding]; other site
1282356008256	catalytic residues [active]
1282356008257	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
1282356008258	peptide synthase; Validated; Region: PRK05691
1282356008259	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1282356008260	acyl-activating enzyme (AAE) consensus motif; other site
1282356008261	active site
1282356008262	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1282356008263	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1282356008264	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1282356008265	acyl-activating enzyme (AAE) consensus motif; other site
1282356008266	AMP binding site [chemical binding]; other site
1282356008267	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1282356008268	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1282356008269	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1282356008270	acyl-activating enzyme (AAE) consensus motif; other site
1282356008271	AMP binding site [chemical binding]; other site
1282356008272	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1282356008273	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1282356008274	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1282356008275	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1282356008276	acyl-activating enzyme (AAE) consensus motif; other site
1282356008277	AMP binding site [chemical binding]; other site
1282356008278	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1282356008279	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
1282356008280	extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037
1282356008281	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1282356008282	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1282356008283	DNA binding residues [nucleotide binding]
1282356008284	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1282356008285	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1282356008286	substrate binding pocket [chemical binding]; other site
1282356008287	membrane-bound complex binding site; other site
1282356008288	hinge residues; other site
1282356008289	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
1282356008290	active site
1282356008291	catalytic site [active]
1282356008292	substrate binding site [chemical binding]; other site
1282356008293	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
1282356008294	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
1282356008295	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
1282356008296	MOSC domain; Region: MOSC; pfam03473
1282356008297	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
1282356008298	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1282356008299	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356008300	active site
1282356008301	phosphorylation site [posttranslational modification]
1282356008302	intermolecular recognition site; other site
1282356008303	dimerization interface [polypeptide binding]; other site
1282356008304	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1282356008305	Histidine kinase; Region: HisKA_3; pfam07730
1282356008306	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356008307	ATP binding site [chemical binding]; other site
1282356008308	Mg2+ binding site [ion binding]; other site
1282356008309	G-X-G motif; other site
1282356008310	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1282356008311	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356008312	active site
1282356008313	phosphorylation site [posttranslational modification]
1282356008314	intermolecular recognition site; other site
1282356008315	dimerization interface [polypeptide binding]; other site
1282356008316	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1282356008317	DNA binding residues [nucleotide binding]
1282356008318	dimerization interface [polypeptide binding]; other site
1282356008319	lipid kinase; Reviewed; Region: PRK13054
1282356008320	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1282356008321	Protein of unknown function (DUF2802); Region: DUF2802; pfam10975
1282356008322	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
1282356008323	putative CheA interaction surface; other site
1282356008324	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
1282356008325	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1282356008326	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1282356008327	P-loop; other site
1282356008328	Magnesium ion binding site [ion binding]; other site
1282356008329	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1282356008330	Magnesium ion binding site [ion binding]; other site
1282356008331	flagellar motor protein MotD; Reviewed; Region: PRK09038
1282356008332	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
1282356008333	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1282356008334	ligand binding site [chemical binding]; other site
1282356008335	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
1282356008336	flagellar motor protein; Reviewed; Region: motC; PRK09109
1282356008337	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
1282356008338	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356008339	active site
1282356008340	phosphorylation site [posttranslational modification]
1282356008341	intermolecular recognition site; other site
1282356008342	dimerization interface [polypeptide binding]; other site
1282356008343	CheB methylesterase; Region: CheB_methylest; pfam01339
1282356008344	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1282356008345	putative binding surface; other site
1282356008346	active site
1282356008347	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
1282356008348	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
1282356008349	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356008350	ATP binding site [chemical binding]; other site
1282356008351	Mg2+ binding site [ion binding]; other site
1282356008352	G-X-G motif; other site
1282356008353	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
1282356008354	Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344
1282356008355	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
1282356008356	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356008357	active site
1282356008358	phosphorylation site [posttranslational modification]
1282356008359	intermolecular recognition site; other site
1282356008360	dimerization interface [polypeptide binding]; other site
1282356008361	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
1282356008362	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1282356008363	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1282356008364	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1282356008365	DNA binding residues [nucleotide binding]
1282356008366	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
1282356008367	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1282356008368	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
1282356008369	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
1282356008370	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1282356008371	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
1282356008372	FHIPEP family; Region: FHIPEP; pfam00771
1282356008373	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
1282356008374	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
1282356008375	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
1282356008376	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
1282356008377	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
1282356008378	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
1282356008379	flagellar motor switch protein; Validated; Region: fliN; PRK05698
1282356008380	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
1282356008381	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
1282356008382	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
1282356008383	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK05696
1282356008384	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
1282356008385	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1282356008386	putative binding surface; other site
1282356008387	active site
1282356008388	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356008389	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1282356008390	active site
1282356008391	phosphorylation site [posttranslational modification]
1282356008392	intermolecular recognition site; other site
1282356008393	dimerization interface [polypeptide binding]; other site
1282356008394	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1282356008395	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356008396	ATP binding site [chemical binding]; other site
1282356008397	Mg2+ binding site [ion binding]; other site
1282356008398	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
1282356008399	G-X-G motif; other site
1282356008400	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1282356008401	anti sigma factor interaction site; other site
1282356008402	regulatory phosphorylation site [posttranslational modification]; other site
1282356008403	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
1282356008404	Flagellar FliJ protein; Region: FliJ; pfam02050
1282356008405	flagellum-specific ATP synthase; Validated; Region: fliI; PRK05688
1282356008406	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
1282356008407	Walker A motif/ATP binding site; other site
1282356008408	Walker B motif; other site
1282356008409	flagellar assembly protein H; Validated; Region: fliH; PRK05687
1282356008410	Flagellar assembly protein FliH; Region: FliH; pfam02108
1282356008411	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
1282356008412	MgtE intracellular N domain; Region: MgtE_N; smart00924
1282356008413	FliG C-terminal domain; Region: FliG_C; pfam01706
1282356008414	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
1282356008415	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
1282356008416	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
1282356008417	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253
1282356008418	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1282356008419	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356008420	active site
1282356008421	phosphorylation site [posttranslational modification]
1282356008422	intermolecular recognition site; other site
1282356008423	dimerization interface [polypeptide binding]; other site
1282356008424	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356008425	Walker A motif; other site
1282356008426	ATP binding site [chemical binding]; other site
1282356008427	Walker B motif; other site
1282356008428	arginine finger; other site
1282356008429	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
1282356008430	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1282356008431	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356008432	putative active site [active]
1282356008433	heme pocket [chemical binding]; other site
1282356008434	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356008435	dimer interface [polypeptide binding]; other site
1282356008436	phosphorylation site [posttranslational modification]
1282356008437	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356008438	ATP binding site [chemical binding]; other site
1282356008439	Mg2+ binding site [ion binding]; other site
1282356008440	G-X-G motif; other site
1282356008441	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1282356008442	Flagellar regulatory protein FleQ; Region: FleQ; pfam06490
1282356008443	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356008444	Walker A motif; other site
1282356008445	ATP binding site [chemical binding]; other site
1282356008446	Walker B motif; other site
1282356008447	arginine finger; other site
1282356008448	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1282356008449	flagellar protein FliS; Validated; Region: fliS; PRK05685
1282356008450	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
1282356008451	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1282356008452	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1282356008453	catalytic residue [active]
1282356008454	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1282356008455	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1282356008456	active site
1282356008457	Rhamnan synthesis protein F; Region: RgpF; pfam05045
1282356008458	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1282356008459	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1282356008460	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
1282356008461	Probable Catalytic site; other site
1282356008462	metal-binding site
1282356008463	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
1282356008464	flagellar capping protein; Reviewed; Region: fliD; PRK08032
1282356008465	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
1282356008466	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
1282356008467	FlaG protein; Region: FlaG; pfam03646
1282356008468	flagellin; Provisional; Region: PRK12806
1282356008469	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1282356008470	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1282356008471	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1282356008472	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
1282356008473	dimer interface [polypeptide binding]; other site
1282356008474	active site
1282356008475	CoA binding pocket [chemical binding]; other site
1282356008476	flagellar hook-associated protein FlgL; Provisional; Region: flgL; PRK12717
1282356008477	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1282356008478	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1282356008479	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK05683
1282356008480	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1282356008481	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1282356008482	Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951
1282356008483	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
1282356008484	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
1282356008485	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
1282356008486	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
1282356008487	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698
1282356008488	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
1282356008489	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
1282356008490	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1282356008491	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1282356008492	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
1282356008493	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1282356008494	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
1282356008495	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1282356008496	MULE transposase domain; Region: MULE; pfam10551
1282356008497	Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283
1282356008498	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1282356008499	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356008500	putative active site [active]
1282356008501	heme pocket [chemical binding]; other site
1282356008502	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356008503	Walker A motif; other site
1282356008504	ATP binding site [chemical binding]; other site
1282356008505	Walker B motif; other site
1282356008506	arginine finger; other site
1282356008507	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
1282356008508	cofactor binding site; other site
1282356008509	metal binding site [ion binding]; metal-binding site
1282356008510	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
1282356008511	aromatic arch; other site
1282356008512	DCoH dimer interaction site [polypeptide binding]; other site
1282356008513	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
1282356008514	DCoH tetramer interaction site [polypeptide binding]; other site
1282356008515	substrate binding site [chemical binding]; other site
1282356008516	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
1282356008517	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1282356008518	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356008519	homodimer interface [polypeptide binding]; other site
1282356008520	catalytic residue [active]
1282356008521	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1282356008522	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
1282356008523	putative active site [active]
1282356008524	putative metal binding site [ion binding]; other site
1282356008525	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1282356008526	EamA-like transporter family; Region: EamA; pfam00892
1282356008527	Rdx family; Region: Rdx; cl01407
1282356008528	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1282356008529	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
1282356008530	active site
1282356008531	nucleophile elbow; other site
1282356008532	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1282356008533	Surface antigen; Region: Bac_surface_Ag; pfam01103
1282356008534	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1282356008535	MULE transposase domain; Region: MULE; pfam10551
1282356008536	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1282356008537	MarR family; Region: MarR_2; pfam12802
1282356008538	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
1282356008539	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1282356008540	ATP binding site [chemical binding]; other site
1282356008541	putative Mg++ binding site [ion binding]; other site
1282356008542	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1282356008543	nucleotide binding region [chemical binding]; other site
1282356008544	ATP-binding site [chemical binding]; other site
1282356008545	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
1282356008546	HRDC domain; Region: HRDC; pfam00570
1282356008547	Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318
1282356008548	yecA family protein; Region: ygfB_yecA; TIGR02292
1282356008549	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
1282356008550	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
1282356008551	Na binding site [ion binding]; other site
1282356008552	PAS domain; Region: PAS; smart00091
1282356008553	PAS fold; Region: PAS_7; pfam12860
1282356008554	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1282356008555	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356008556	dimer interface [polypeptide binding]; other site
1282356008557	phosphorylation site [posttranslational modification]
1282356008558	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356008559	ATP binding site [chemical binding]; other site
1282356008560	Mg2+ binding site [ion binding]; other site
1282356008561	G-X-G motif; other site
1282356008562	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1282356008563	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356008564	active site
1282356008565	phosphorylation site [posttranslational modification]
1282356008566	intermolecular recognition site; other site
1282356008567	dimerization interface [polypeptide binding]; other site
1282356008568	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
1282356008569	RmuC family; Region: RmuC; pfam02646
1282356008570	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
1282356008571	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1282356008572	catalytic residues [active]
1282356008573	dimer interface [polypeptide binding]; other site
1282356008574	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356008575	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1282356008576	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1282356008577	MarR family; Region: MarR; pfam01047
1282356008578	cobalamin synthase; Reviewed; Region: cobS; PRK00235
1282356008579	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1282356008580	catalytic core [active]
1282356008581	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
1282356008582	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
1282356008583	putative dimer interface [polypeptide binding]; other site
1282356008584	active site pocket [active]
1282356008585	putative cataytic base [active]
1282356008586	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
1282356008587	homotrimer interface [polypeptide binding]; other site
1282356008588	Walker A motif; other site
1282356008589	GTP binding site [chemical binding]; other site
1282356008590	Walker B motif; other site
1282356008591	cobyric acid synthase; Provisional; Region: PRK00784
1282356008592	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
1282356008593	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1282356008594	catalytic triad [active]
1282356008595	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
1282356008596	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1282356008597	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356008598	homodimer interface [polypeptide binding]; other site
1282356008599	catalytic residue [active]
1282356008600	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
1282356008601	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1282356008602	FMN binding site [chemical binding]; other site
1282356008603	dimer interface [polypeptide binding]; other site
1282356008604	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
1282356008605	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1282356008606	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
1282356008607	catalytic triad [active]
1282356008608	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
1282356008609	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
1282356008610	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
1282356008611	Walker A motif; other site
1282356008612	homodimer interface [polypeptide binding]; other site
1282356008613	ATP binding site [chemical binding]; other site
1282356008614	hydroxycobalamin binding site [chemical binding]; other site
1282356008615	Walker B motif; other site
1282356008616	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
1282356008617	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1282356008618	NlpC/P60 family; Region: NLPC_P60; pfam00877
1282356008619	NlpC/P60 family; Region: NLPC_P60; pfam00877
1282356008620	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
1282356008621	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356008622	Walker A motif; other site
1282356008623	ATP binding site [chemical binding]; other site
1282356008624	Walker B motif; other site
1282356008625	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1282356008626	arginine finger; other site
1282356008627	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1282356008628	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1282356008629	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3249
1282356008630	Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839
1282356008631	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1282356008632	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1282356008633	dimerization interface [polypeptide binding]; other site
1282356008634	putative ATP binding site [chemical binding]; other site
1282356008635	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
1282356008636	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1282356008637	active site
1282356008638	substrate binding site [chemical binding]; other site
1282356008639	cosubstrate binding site; other site
1282356008640	catalytic site [active]
1282356008641	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
1282356008642	Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831
1282356008643	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
1282356008644	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
1282356008645	homodimer interface [polypeptide binding]; other site
1282356008646	metal binding site [ion binding]; metal-binding site
1282356008647	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
1282356008648	homodimer interface [polypeptide binding]; other site
1282356008649	active site
1282356008650	putative chemical substrate binding site [chemical binding]; other site
1282356008651	metal binding site [ion binding]; metal-binding site
1282356008652	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1282356008653	HD domain; Region: HD_4; pfam13328
1282356008654	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1282356008655	synthetase active site [active]
1282356008656	NTP binding site [chemical binding]; other site
1282356008657	metal binding site [ion binding]; metal-binding site
1282356008658	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1282356008659	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1282356008660	active site
1282356008661	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1282356008662	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
1282356008663	TRAM domain; Region: TRAM; pfam01938
1282356008664	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356008665	S-adenosylmethionine binding site [chemical binding]; other site
1282356008666	cysteine synthase B; Region: cysM; TIGR01138
1282356008667	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1282356008668	dimer interface [polypeptide binding]; other site
1282356008669	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356008670	catalytic residue [active]
1282356008671	Leucine rich repeat; Region: LRR_8; pfam13855
1282356008672	Leucine rich repeat; Region: LRR_8; pfam13855
1282356008673	Uncharacterized conserved protein [Function unknown]; Region: COG3148
1282356008674	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356008675	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356008676	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1282356008677	dimerization interface [polypeptide binding]; other site
1282356008678	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
1282356008679	agmatinase; Region: agmatinase; TIGR01230
1282356008680	oligomer interface [polypeptide binding]; other site
1282356008681	putative active site [active]
1282356008682	Mn binding site [ion binding]; other site
1282356008683	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479
1282356008684	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1282356008685	Na binding site [ion binding]; other site
1282356008686	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
1282356008687	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
1282356008688	Na binding site [ion binding]; other site
1282356008689	putative substrate binding site [chemical binding]; other site
1282356008690	Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945
1282356008691	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
1282356008692	S1 domain; Region: S1_2; pfam13509
1282356008693	S1 domain; Region: S1_2; pfam13509
1282356008694	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
1282356008695	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
1282356008696	helicase 45; Provisional; Region: PTZ00424
1282356008697	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1282356008698	ATP binding site [chemical binding]; other site
1282356008699	Mg++ binding site [ion binding]; other site
1282356008700	motif III; other site
1282356008701	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1282356008702	nucleotide binding region [chemical binding]; other site
1282356008703	ATP-binding site [chemical binding]; other site
1282356008704	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1282356008705	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1282356008706	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1282356008707	Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342
1282356008708	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356008709	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356008710	LysR substrate binding domain; Region: LysR_substrate; pfam03466
1282356008711	dimerization interface [polypeptide binding]; other site
1282356008712	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
1282356008713	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
1282356008714	substrate binding site [chemical binding]; other site
1282356008715	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1282356008716	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1282356008717	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1282356008718	Walker A/P-loop; other site
1282356008719	ATP binding site [chemical binding]; other site
1282356008720	Q-loop/lid; other site
1282356008721	ABC transporter signature motif; other site
1282356008722	Walker B; other site
1282356008723	D-loop; other site
1282356008724	H-loop/switch region; other site
1282356008725	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
1282356008726	amphipathic channel; other site
1282356008727	Asn-Pro-Ala signature motifs; other site
1282356008728	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
1282356008729	Protein of unknown function, DUF482; Region: DUF482; pfam04339
1282356008730	Putative zinc-finger; Region: zf-HC2; pfam13490
1282356008731	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
1282356008732	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1282356008733	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
1282356008734	DNA binding residues [nucleotide binding]
1282356008735	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515
1282356008736	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1282356008737	dimer interface [polypeptide binding]; other site
1282356008738	active site
1282356008739	CoA binding pocket [chemical binding]; other site
1282356008740	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
1282356008741	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1282356008742	ATP binding site [chemical binding]; other site
1282356008743	putative Mg++ binding site [ion binding]; other site
1282356008744	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1282356008745	nucleotide binding region [chemical binding]; other site
1282356008746	ATP-binding site [chemical binding]; other site
1282356008747	Helicase associated domain (HA2); Region: HA2; pfam04408
1282356008748	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
1282356008749	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
1282356008750	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
1282356008751	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
1282356008752	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
1282356008753	bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946
1282356008754	EamA-like transporter family; Region: EamA; pfam00892
1282356008755	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1282356008756	EamA-like transporter family; Region: EamA; pfam00892
1282356008757	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356008758	PAS domain; Region: PAS_9; pfam13426
1282356008759	putative active site [active]
1282356008760	heme pocket [chemical binding]; other site
1282356008761	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1282356008762	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356008763	dimer interface [polypeptide binding]; other site
1282356008764	putative CheW interface [polypeptide binding]; other site
1282356008765	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571
1282356008766	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
1282356008767	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
1282356008768	Low-spin heme binding site [chemical binding]; other site
1282356008769	Putative water exit pathway; other site
1282356008770	Binuclear center (active site) [active]
1282356008771	Putative proton exit pathway; other site
1282356008772	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
1282356008773	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
1282356008774	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
1282356008775	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
1282356008776	Cytochrome c; Region: Cytochrom_C; pfam00034
1282356008777	Cytochrome c; Region: Cytochrom_C; pfam00034
1282356008778	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
1282356008779	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1282356008780	oligomeric interface; other site
1282356008781	putative active site [active]
1282356008782	homodimer interface [polypeptide binding]; other site
1282356008783	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
1282356008784	4Fe-4S binding domain; Region: Fer4_5; pfam12801
1282356008785	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
1282356008786	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198
1282356008787	FixH; Region: FixH; pfam05751
1282356008788	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
1282356008789	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1282356008790	Heavy-metal-associated domain; Region: HMA; pfam00403
1282356008791	metal-binding site [ion binding]
1282356008792	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1282356008793	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1282356008794	motif II; other site
1282356008795	Uncharacterized protein, possibly involved in nitrogen fixation [Inorganic ion transport and metabolism]; Region: FixS; COG3197
1282356008796	Uncharacterized conserved protein [Function unknown]; Region: COG2836
1282356008797	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
1282356008798	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1282356008799	FeS/SAM binding site; other site
1282356008800	HemN C-terminal domain; Region: HemN_C; pfam06969
1282356008801	hypothetical protein; Provisional; Region: PRK11281
1282356008802	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
1282356008803	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1282356008804	ligand binding site [chemical binding]; other site
1282356008805	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1282356008806	putative switch regulator; other site
1282356008807	non-specific DNA interactions [nucleotide binding]; other site
1282356008808	DNA binding site [nucleotide binding]
1282356008809	sequence specific DNA binding site [nucleotide binding]; other site
1282356008810	putative cAMP binding site [chemical binding]; other site
1282356008811	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1282356008812	active site
1282356008813	recombination protein RecR; Reviewed; Region: recR; PRK00076
1282356008814	RecR protein; Region: RecR; pfam02132
1282356008815	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1282356008816	putative active site [active]
1282356008817	putative metal-binding site [ion binding]; other site
1282356008818	tetramer interface [polypeptide binding]; other site
1282356008819	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
1282356008820	Prostaglandin dehydrogenases; Region: PGDH; cd05288
1282356008821	NAD(P) binding site [chemical binding]; other site
1282356008822	substrate binding site [chemical binding]; other site
1282356008823	dimer interface [polypeptide binding]; other site
1282356008824	hypothetical protein; Validated; Region: PRK00153
1282356008825	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
1282356008826	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356008827	Walker A motif; other site
1282356008828	ATP binding site [chemical binding]; other site
1282356008829	Walker B motif; other site
1282356008830	arginine finger; other site
1282356008831	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1282356008832	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1282356008833	Protein of unknown function (DUF3380); Region: DUF3380; pfam11860
1282356008834	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
1282356008835	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
1282356008836	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1282356008837	Ligase N family; Region: LIGANc; smart00532
1282356008838	nucleotide binding pocket [chemical binding]; other site
1282356008839	K-X-D-G motif; other site
1282356008840	catalytic site [active]
1282356008841	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1282356008842	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1282356008843	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
1282356008844	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
1282356008845	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
1282356008846	DNA binding site [nucleotide binding]
1282356008847	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1282356008848	Dimer interface [polypeptide binding]; other site
1282356008849	cell division protein ZipA; Reviewed; Region: zipA; PRK00269
1282356008850	Cell division protein [Cell division and chromosome partitioning]; Region: ZipA; COG3115
1282356008851	FtsZ protein binding site [polypeptide binding]; other site
1282356008852	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1282356008853	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1282356008854	Walker A/P-loop; other site
1282356008855	ATP binding site [chemical binding]; other site
1282356008856	Q-loop/lid; other site
1282356008857	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
1282356008858	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1282356008859	ABC transporter signature motif; other site
1282356008860	Walker B; other site
1282356008861	D-loop; other site
1282356008862	H-loop/switch region; other site
1282356008863	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1282356008864	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1282356008865	DNA-binding site [nucleotide binding]; DNA binding site
1282356008866	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
1282356008867	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1282356008868	catalytic loop [active]
1282356008869	iron binding site [ion binding]; other site
1282356008870	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1282356008871	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
1282356008872	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
1282356008873	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1282356008874	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1282356008875	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1282356008876	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
1282356008877	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1282356008878	guanine deaminase; Provisional; Region: PRK09228
1282356008879	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
1282356008880	active site
1282356008881	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1282356008882	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1282356008883	DNA-binding site [nucleotide binding]; DNA binding site
1282356008884	FCD domain; Region: FCD; pfam07729
1282356008885	benzoate transporter; Region: benE; TIGR00843
1282356008886	Benzoate membrane transport protein; Region: BenE; pfam03594
1282356008887	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1282356008888	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1282356008889	putative DNA binding site [nucleotide binding]; other site
1282356008890	putative Zn2+ binding site [ion binding]; other site
1282356008891	AsnC family; Region: AsnC_trans_reg; pfam01037
1282356008892	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1282356008893	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
1282356008894	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1282356008895	inhibitor-cofactor binding pocket; inhibition site
1282356008896	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356008897	catalytic residue [active]
1282356008898	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1282356008899	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
1282356008900	putative ligand binding site [chemical binding]; other site
1282356008901	NAD binding site [chemical binding]; other site
1282356008902	dimerization interface [polypeptide binding]; other site
1282356008903	catalytic site [active]
1282356008904	succinic semialdehyde dehydrogenase; Region: PLN02278
1282356008905	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1282356008906	tetramerization interface [polypeptide binding]; other site
1282356008907	NAD(P) binding site [chemical binding]; other site
1282356008908	catalytic residues [active]
1282356008909	acetylornithine deacetylase; Provisional; Region: PRK07522
1282356008910	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
1282356008911	metal binding site [ion binding]; metal-binding site
1282356008912	putative dimer interface [polypeptide binding]; other site
1282356008913	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1282356008914	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1282356008915	Walker A/P-loop; other site
1282356008916	ATP binding site [chemical binding]; other site
1282356008917	Q-loop/lid; other site
1282356008918	ABC transporter signature motif; other site
1282356008919	Walker B; other site
1282356008920	D-loop; other site
1282356008921	H-loop/switch region; other site
1282356008922	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1282356008923	Walker A/P-loop; other site
1282356008924	ATP binding site [chemical binding]; other site
1282356008925	Q-loop/lid; other site
1282356008926	ABC transporter signature motif; other site
1282356008927	Walker B; other site
1282356008928	D-loop; other site
1282356008929	H-loop/switch region; other site
1282356008930	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1282356008931	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
1282356008932	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356008933	dimer interface [polypeptide binding]; other site
1282356008934	conserved gate region; other site
1282356008935	putative PBP binding loops; other site
1282356008936	ABC-ATPase subunit interface; other site
1282356008937	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1282356008938	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356008939	dimer interface [polypeptide binding]; other site
1282356008940	conserved gate region; other site
1282356008941	putative PBP binding loops; other site
1282356008942	ABC-ATPase subunit interface; other site
1282356008943	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
1282356008944	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1282356008945	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1282356008946	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1282356008947	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
1282356008948	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
1282356008949	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1282356008950	Coenzyme A binding pocket [chemical binding]; other site
1282356008951	Protein of unknown function (DUF861); Region: Cupin_3; pfam05899
1282356008952	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
1282356008953	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1282356008954	NAD binding site [chemical binding]; other site
1282356008955	catalytic residues [active]
1282356008956	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1282356008957	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1282356008958	Protein with unknown function (DUF469); Region: DUF469; cl01237
1282356008959	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
1282356008960	CHASE domain; Region: CHASE; pfam03924
1282356008961	PAS domain; Region: PAS; smart00091
1282356008962	PAS domain; Region: PAS_9; pfam13426
1282356008963	putative active site [active]
1282356008964	heme pocket [chemical binding]; other site
1282356008965	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356008966	putative active site [active]
1282356008967	heme pocket [chemical binding]; other site
1282356008968	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1282356008969	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1282356008970	metal binding site [ion binding]; metal-binding site
1282356008971	active site
1282356008972	I-site; other site
1282356008973	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
1282356008974	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
1282356008975	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1282356008976	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356008977	S-adenosylmethionine binding site [chemical binding]; other site
1282356008978	Ribosome modulation factor; Region: RMF; pfam04957
1282356008979	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
1282356008980	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
1282356008981	quinone interaction residues [chemical binding]; other site
1282356008982	active site
1282356008983	catalytic residues [active]
1282356008984	FMN binding site [chemical binding]; other site
1282356008985	substrate binding site [chemical binding]; other site
1282356008986	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1282356008987	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1282356008988	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1282356008989	catalytic residue [active]
1282356008990	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1282356008991	DNA binding site [nucleotide binding]
1282356008992	type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339
1282356008993	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1282356008994	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1282356008995	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1282356008996	NMT1-like family; Region: NMT1_2; pfam13379
1282356008997	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
1282356008998	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356008999	active site
1282356009000	phosphorylation site [posttranslational modification]
1282356009001	intermolecular recognition site; other site
1282356009002	dimerization interface [polypeptide binding]; other site
1282356009003	ANTAR domain; Region: ANTAR; pfam03861
1282356009004	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
1282356009005	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356009006	putative substrate translocation pore; other site
1282356009007	Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631
1282356009008	active site
1282356009009	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1282356009010	active site
1282356009011	ATP binding site [chemical binding]; other site
1282356009012	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1282356009013	substrate binding site [chemical binding]; other site
1282356009014	activation loop (A-loop); other site
1282356009015	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
1282356009016	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1282356009017	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1282356009018	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1282356009019	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1282356009020	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1282356009021	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
1282356009022	[2Fe-2S] cluster binding site [ion binding]; other site
1282356009023	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
1282356009024	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
1282356009025	[4Fe-4S] binding site [ion binding]; other site
1282356009026	molybdopterin cofactor binding site; other site
1282356009027	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
1282356009028	molybdopterin cofactor binding site; other site
1282356009029	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1282356009030	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1282356009031	active site
1282356009032	SAM binding site [chemical binding]; other site
1282356009033	homodimer interface [polypeptide binding]; other site
1282356009034	OprF membrane domain; Region: OprF; pfam05736
1282356009035	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1282356009036	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1282356009037	ligand binding site [chemical binding]; other site
1282356009038	RNA polymerase sigma factor SigX; Reviewed; Region: PRK09640
1282356009039	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1282356009040	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1282356009041	DNA binding residues [nucleotide binding]
1282356009042	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
1282356009043	Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833
1282356009044	Cl binding site [ion binding]; other site
1282356009045	oligomer interface [polypeptide binding]; other site
1282356009046	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
1282356009047	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1282356009048	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1282356009049	phosphoenolpyruvate synthase; Validated; Region: PRK06464
1282356009050	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1282356009051	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1282356009052	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1282356009053	PEP synthetase regulatory protein; Provisional; Region: PRK05339
1282356009054	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1282356009055	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1282356009056	DNA-binding site [nucleotide binding]; DNA binding site
1282356009057	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1282356009058	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356009059	homodimer interface [polypeptide binding]; other site
1282356009060	catalytic residue [active]
1282356009061	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
1282356009062	EamA-like transporter family; Region: EamA; pfam00892
1282356009063	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
1282356009064	MPN+ (JAMM) motif; other site
1282356009065	Zinc-binding site [ion binding]; other site
1282356009066	hypothetical protein; Validated; Region: PRK07411
1282356009067	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1282356009068	ATP binding site [chemical binding]; other site
1282356009069	substrate interface [chemical binding]; other site
1282356009070	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
1282356009071	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1282356009072	active site residue [active]
1282356009073	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1282356009074	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1282356009075	dimer interface [polypeptide binding]; other site
1282356009076	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356009077	catalytic residue [active]
1282356009078	serine O-acetyltransferase; Region: cysE; TIGR01172
1282356009079	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1282356009080	trimer interface [polypeptide binding]; other site
1282356009081	active site
1282356009082	substrate binding site [chemical binding]; other site
1282356009083	CoA binding site [chemical binding]; other site
1282356009084	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
1282356009085	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1282356009086	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
1282356009087	2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333
1282356009088	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
1282356009089	substrate binding site [chemical binding]; other site
1282356009090	ligand binding site [chemical binding]; other site
1282356009091	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
1282356009092	substrate binding site [chemical binding]; other site
1282356009093	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1282356009094	Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108
1282356009095	dimer interface [polypeptide binding]; other site
1282356009096	active site
1282356009097	citrylCoA binding site [chemical binding]; other site
1282356009098	oxalacetate/citrate binding site [chemical binding]; other site
1282356009099	coenzyme A binding site [chemical binding]; other site
1282356009100	catalytic triad [active]
1282356009101	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1282356009102	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1282356009103	tetramer interface [polypeptide binding]; other site
1282356009104	active site
1282356009105	Mg2+/Mn2+ binding site [ion binding]; other site
1282356009106	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1282356009107	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1282356009108	DNA-binding site [nucleotide binding]; DNA binding site
1282356009109	FCD domain; Region: FCD; pfam07729
1282356009110	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
1282356009111	Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400
1282356009112	7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402
1282356009113	alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291
1282356009114	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1282356009115	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
1282356009116	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1282356009117	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
1282356009118	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
1282356009119	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1282356009120	Active Sites [active]
1282356009121	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
1282356009122	hydrolase; Region: PLN02811
1282356009123	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1282356009124	motif II; other site
1282356009125	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1282356009126	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1282356009127	non-specific DNA binding site [nucleotide binding]; other site
1282356009128	salt bridge; other site
1282356009129	sequence-specific DNA binding site [nucleotide binding]; other site
1282356009130	Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861
1282356009131	Domain of unknown function (DUF4337); Region: DUF4337; pfam14235
1282356009132	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
1282356009133	portal vertex protein; Provisional; Region: Q; PHA02536
1282356009134	Phage portal protein; Region: Phage_portal; pfam04860
1282356009135	terminase ATPase subunit; Provisional; Region: P; PHA02535
1282356009136	Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056
1282356009137	Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373
1282356009138	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838
1282356009139	capsid protein; Provisional; Region: N; PHA02538
1282356009140	terminase endonuclease subunit; Provisional; Region: M; PHA02537
1282356009141	Phage small terminase subunit; Region: Phage_term_smal; pfam05944
1282356009142	Phage head completion protein (GPL); Region: Phage_GPL; pfam05926
1282356009143	Phage Tail Protein X; Region: Phage_tail_X; pfam05489
1282356009144	Protein of unknown function (DUF754); Region: DUF754; pfam05449
1282356009145	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1282356009146	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1282356009147	Protein of unknown function (DUF3380); Region: DUF3380; pfam11860
1282356009148	phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495
1282356009149	P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891
1282356009150	Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069
1282356009151	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
1282356009152	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
1282356009153	Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812
1282356009154	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
1282356009155	baseplate assembly protein; Provisional; Region: J; PHA02568
1282356009156	Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385
1282356009157	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
1282356009158	major tail sheath protein; Provisional; Region: FI; PHA02560
1282356009159	major tail tube protein; Provisional; Region: FII; PHA02600
1282356009160	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
1282356009161	Phage P2 GpE; Region: Phage_P2_GpE; pfam06528
1282356009162	Phage-related tail protein [Function unknown]; Region: COG5283
1282356009163	Phage P2 GpU; Region: Phage_P2_GpU; pfam06995
1282356009164	tail protein; Provisional; Region: D; PHA02561
1282356009165	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
1282356009166	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
1282356009167	Double zinc ribbon; Region: DZR; pfam12773
1282356009168	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1282356009169	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1282356009170	non-specific DNA binding site [nucleotide binding]; other site
1282356009171	salt bridge; other site
1282356009172	sequence-specific DNA binding site [nucleotide binding]; other site
1282356009173	phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111
1282356009174	Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606
1282356009175	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
1282356009176	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1282356009177	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1282356009178	active site
1282356009179	DNA binding site [nucleotide binding]
1282356009180	Int/Topo IB signature motif; other site
1282356009181	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1282356009182	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1282356009183	substrate binding site [chemical binding]; other site
1282356009184	oxyanion hole (OAH) forming residues; other site
1282356009185	trimer interface [polypeptide binding]; other site
1282356009186	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1282356009187	putative acyl-acceptor binding pocket; other site
1282356009188	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1282356009189	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
1282356009190	oligomer interface [polypeptide binding]; other site
1282356009191	metal binding site [ion binding]; metal-binding site
1282356009192	metal binding site [ion binding]; metal-binding site
1282356009193	putative Cl binding site [ion binding]; other site
1282356009194	basic sphincter; other site
1282356009195	hydrophobic gate; other site
1282356009196	periplasmic entrance; other site
1282356009197	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
1282356009198	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
1282356009199	catalytic triad [active]
1282356009200	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1282356009201	Cytochrome c; Region: Cytochrom_C; pfam00034
1282356009202	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1282356009203	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
1282356009204	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1282356009205	Uncharacterized conserved protein [Function unknown]; Region: COG2308
1282356009206	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
1282356009207	Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876
1282356009208	putative lipid binding site [chemical binding]; other site
1282356009209	Flagellin N-methylase; Region: FliB; cl00497
1282356009210	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1282356009211	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1282356009212	DNA-binding site [nucleotide binding]; DNA binding site
1282356009213	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1282356009214	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356009215	homodimer interface [polypeptide binding]; other site
1282356009216	catalytic residue [active]
1282356009217	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1282356009218	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1282356009219	ligand binding site [chemical binding]; other site
1282356009220	Domain of unknown function (DUF4398); Region: DUF4398; pfam14346
1282356009221	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1282356009222	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1282356009223	substrate binding pocket [chemical binding]; other site
1282356009224	membrane-bound complex binding site; other site
1282356009225	hinge residues; other site
1282356009226	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1282356009227	electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022
1282356009228	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1282356009229	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1282356009230	Ligand binding site [chemical binding]; other site
1282356009231	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1282356009232	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
1282356009233	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1282356009234	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
1282356009235	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
1282356009236	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1282356009237	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1282356009238	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1282356009239	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
1282356009240	putative NAD(P) binding site [chemical binding]; other site
1282356009241	putative substrate binding site [chemical binding]; other site
1282356009242	catalytic Zn binding site [ion binding]; other site
1282356009243	structural Zn binding site [ion binding]; other site
1282356009244	dimer interface [polypeptide binding]; other site
1282356009245	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1282356009246	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1282356009247	Bacterial transcriptional regulator; Region: IclR; pfam01614
1282356009248	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1282356009249	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1282356009250	TM-ABC transporter signature motif; other site
1282356009251	L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288
1282356009252	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1282356009253	Walker A/P-loop; other site
1282356009254	ATP binding site [chemical binding]; other site
1282356009255	Q-loop/lid; other site
1282356009256	ABC transporter signature motif; other site
1282356009257	Walker B; other site
1282356009258	D-loop; other site
1282356009259	H-loop/switch region; other site
1282356009260	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1282356009261	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
1282356009262	Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540
1282356009263	ligand binding site [chemical binding]; other site
1282356009264	short chain dehydrogenase; Provisional; Region: PRK07063
1282356009265	classical (c) SDRs; Region: SDR_c; cd05233
1282356009266	NAD(P) binding site [chemical binding]; other site
1282356009267	active site
1282356009268	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1282356009269	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1282356009270	Coenzyme A binding pocket [chemical binding]; other site
1282356009271	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1282356009272	The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); Region: A_NRPS_SidN3_like; cd05918
1282356009273	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1282356009274	acyl-activating enzyme (AAE) consensus motif; other site
1282356009275	AMP binding site [chemical binding]; other site
1282356009276	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
1282356009277	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1282356009278	putative trimer interface [polypeptide binding]; other site
1282356009279	putative CoA binding site [chemical binding]; other site
1282356009280	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1282356009281	putative trimer interface [polypeptide binding]; other site
1282356009282	putative CoA binding site [chemical binding]; other site
1282356009283	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1282356009284	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1282356009285	substrate binding site [chemical binding]; other site
1282356009286	ATP binding site [chemical binding]; other site
1282356009287	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1282356009288	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
1282356009289	Na binding site [ion binding]; other site
1282356009290	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
1282356009291	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1282356009292	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1282356009293	DNA-binding site [nucleotide binding]; DNA binding site
1282356009294	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1282356009295	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816
1282356009296	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
1282356009297	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
1282356009298	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1282356009299	FeS/SAM binding site; other site
1282356009300	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1282356009301	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1282356009302	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1282356009303	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1282356009304	active site
1282356009305	DNA polymerase III subunit delta'; Validated; Region: PRK05707
1282356009306	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1282356009307	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1282356009308	thymidylate kinase; Validated; Region: tmk; PRK00698
1282356009309	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1282356009310	TMP-binding site; other site
1282356009311	ATP-binding site [chemical binding]; other site
1282356009312	YceG-like family; Region: YceG; pfam02618
1282356009313	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
1282356009314	dimerization interface [polypeptide binding]; other site
1282356009315	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1282356009316	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
1282356009317	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356009318	catalytic residue [active]
1282356009319	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
1282356009320	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1282356009321	dimer interface [polypeptide binding]; other site
1282356009322	active site
1282356009323	acyl carrier protein; Provisional; Region: acpP; PRK00982
1282356009324	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1282356009325	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1282356009326	NAD(P) binding site [chemical binding]; other site
1282356009327	homotetramer interface [polypeptide binding]; other site
1282356009328	homodimer interface [polypeptide binding]; other site
1282356009329	active site
1282356009330	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1282356009331	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1282356009332	putative phosphate acyltransferase; Provisional; Region: PRK05331
1282356009333	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
1282356009334	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
1282356009335	Maf-like protein; Region: Maf; pfam02545
1282356009336	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1282356009337	active site
1282356009338	dimer interface [polypeptide binding]; other site
1282356009339	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
1282356009340	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
1282356009341	tandem repeat interface [polypeptide binding]; other site
1282356009342	oligomer interface [polypeptide binding]; other site
1282356009343	active site residues [active]
1282356009344	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1282356009345	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1282356009346	motif II; other site
1282356009347	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
1282356009348	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1282356009349	RNA binding surface [nucleotide binding]; other site
1282356009350	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1282356009351	active site
1282356009352	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
1282356009353	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1282356009354	homodimer interface [polypeptide binding]; other site
1282356009355	oligonucleotide binding site [chemical binding]; other site
1282356009356	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
1282356009357	Ligand binding site; other site
1282356009358	metal-binding site
1282356009359	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
1282356009360	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1282356009361	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1282356009362	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
1282356009363	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1282356009364	PhoQ Sensor; Region: PhoQ_Sensor; pfam08918
1282356009365	sensor protein PhoQ; Provisional; Region: PRK10815
1282356009366	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356009367	ATP binding site [chemical binding]; other site
1282356009368	G-X-G motif; other site
1282356009369	DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816
1282356009370	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356009371	active site
1282356009372	phosphorylation site [posttranslational modification]
1282356009373	intermolecular recognition site; other site
1282356009374	dimerization interface [polypeptide binding]; other site
1282356009375	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1282356009376	DNA binding site [nucleotide binding]
1282356009377	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
1282356009378	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1282356009379	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1282356009380	dimerization interface [polypeptide binding]; other site
1282356009381	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356009382	dimer interface [polypeptide binding]; other site
1282356009383	phosphorylation site [posttranslational modification]
1282356009384	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356009385	ATP binding site [chemical binding]; other site
1282356009386	Mg2+ binding site [ion binding]; other site
1282356009387	G-X-G motif; other site
1282356009388	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
1282356009389	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356009390	active site
1282356009391	phosphorylation site [posttranslational modification]
1282356009392	intermolecular recognition site; other site
1282356009393	dimerization interface [polypeptide binding]; other site
1282356009394	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1282356009395	DNA binding site [nucleotide binding]
1282356009396	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
1282356009397	ATP cone domain; Region: ATP-cone; pfam03477
1282356009398	ATP cone domain; Region: ATP-cone; pfam03477
1282356009399	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1282356009400	active site
1282356009401	dimer interface [polypeptide binding]; other site
1282356009402	catalytic residues [active]
1282356009403	effector binding site; other site
1282356009404	R2 peptide binding site; other site
1282356009405	mycofactocin system FadH/OYE family oxidoreductase 1; Region: mycofact_OYE_1; TIGR03996
1282356009406	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
1282356009407	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1282356009408	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
1282356009409	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
1282356009410	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
1282356009411	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
1282356009412	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
1282356009413	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1282356009414	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1282356009415	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
1282356009416	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
1282356009417	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
1282356009418	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1282356009419	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356009420	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
1282356009421	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1282356009422	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356009423	active site
1282356009424	phosphorylation site [posttranslational modification]
1282356009425	intermolecular recognition site; other site
1282356009426	dimerization interface [polypeptide binding]; other site
1282356009427	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018
1282356009428	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
1282356009429	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
1282356009430	FlgN protein; Region: FlgN; pfam05130
1282356009431	Flagellar regulator YcgR; Region: YcgR; pfam07317
1282356009432	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
1282356009433	PilZ domain; Region: PilZ; pfam07238
1282356009434	putative MFS family transporter protein; Provisional; Region: PRK03633
1282356009435	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356009436	putative substrate translocation pore; other site
1282356009437	Arc-like DNA binding domain; Region: Arc; pfam03869
1282356009438	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1282356009439	MgtE intracellular N domain; Region: MgtE_N; smart00924
1282356009440	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1282356009441	Divalent cation transporter; Region: MgtE; pfam01769
1282356009442	carbon storage regulator; Provisional; Region: PRK01712
1282356009443	aspartate kinase; Reviewed; Region: PRK06635
1282356009444	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
1282356009445	putative nucleotide binding site [chemical binding]; other site
1282356009446	putative catalytic residues [active]
1282356009447	putative Mg ion binding site [ion binding]; other site
1282356009448	putative aspartate binding site [chemical binding]; other site
1282356009449	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
1282356009450	putative allosteric regulatory site; other site
1282356009451	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
1282356009452	putative allosteric regulatory residue; other site
1282356009453	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1282356009454	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1282356009455	motif 1; other site
1282356009456	active site
1282356009457	motif 2; other site
1282356009458	motif 3; other site
1282356009459	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1282356009460	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
1282356009461	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
1282356009462	tetramer interface [polypeptide binding]; other site
1282356009463	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356009464	catalytic residue [active]
1282356009465	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-II; Region: Lumazine_synthase-II; cd09208
1282356009466	active site
1282356009467	homopentamer interface [polypeptide binding]; other site
1282356009468	dimer interface [polypeptide binding]; other site
1282356009469	succinylglutamate desuccinylase; Provisional; Region: PRK05324
1282356009470	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
1282356009471	active site
1282356009472	Zn binding site [ion binding]; other site
1282356009473	succinylarginine dihydrolase; Provisional; Region: PRK13281
1282356009474	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
1282356009475	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
1282356009476	NAD(P) binding site [chemical binding]; other site
1282356009477	catalytic residues [active]
1282356009478	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
1282356009479	arginine N-succinyltransferase; Region: arg_catab_AstA; TIGR03244
1282356009480	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
1282356009481	Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440
1282356009482	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
1282356009483	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1282356009484	inhibitor-cofactor binding pocket; inhibition site
1282356009485	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356009486	catalytic residue [active]
1282356009487	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
1282356009488	Leucine rich repeat; Region: LRR_8; pfam13855
1282356009489	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
1282356009490	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
1282356009491	Leucine rich repeat; Region: LRR_8; pfam13855
1282356009492	Substrate binding site [chemical binding]; other site
1282356009493	Leucine rich repeat; Region: LRR_8; pfam13855
1282356009494	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1282356009495	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
1282356009496	conserved cys residue [active]
1282356009497	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1282356009498	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1282356009499	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
1282356009500	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1282356009501	Walker A/P-loop; other site
1282356009502	ATP binding site [chemical binding]; other site
1282356009503	Q-loop/lid; other site
1282356009504	ABC transporter signature motif; other site
1282356009505	Walker B; other site
1282356009506	D-loop; other site
1282356009507	H-loop/switch region; other site
1282356009508	Predicted deacylase [General function prediction only]; Region: COG3608
1282356009509	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
1282356009510	active site
1282356009511	Zn binding site [ion binding]; other site
1282356009512	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356009513	dimer interface [polypeptide binding]; other site
1282356009514	conserved gate region; other site
1282356009515	putative PBP binding loops; other site
1282356009516	ABC-ATPase subunit interface; other site
1282356009517	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1282356009518	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356009519	dimer interface [polypeptide binding]; other site
1282356009520	conserved gate region; other site
1282356009521	putative PBP binding loops; other site
1282356009522	ABC-ATPase subunit interface; other site
1282356009523	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
1282356009524	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1282356009525	substrate binding pocket [chemical binding]; other site
1282356009526	membrane-bound complex binding site; other site
1282356009527	hinge residues; other site
1282356009528	acetyl-CoA synthetase; Provisional; Region: PRK00174
1282356009529	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
1282356009530	active site
1282356009531	CoA binding site [chemical binding]; other site
1282356009532	acyl-activating enzyme (AAE) consensus motif; other site
1282356009533	AMP binding site [chemical binding]; other site
1282356009534	acetate binding site [chemical binding]; other site
1282356009535	Protein of unknown function (DUF2790); Region: DUF2790; pfam10976
1282356009536	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1282356009537	dimer interface [polypeptide binding]; other site
1282356009538	putative radical transfer pathway; other site
1282356009539	diiron center [ion binding]; other site
1282356009540	tyrosyl radical; other site
1282356009541	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1282356009542	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1282356009543	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1282356009544	salt bridge; other site
1282356009545	non-specific DNA binding site [nucleotide binding]; other site
1282356009546	sequence-specific DNA binding site [nucleotide binding]; other site
1282356009547	Amidase; Region: Amidase; cl11426
1282356009548	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1282356009549	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
1282356009550	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1282356009551	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1282356009552	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
1282356009553	diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245
1282356009554	MASE2 domain; Region: MASE2; pfam05230
1282356009555	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1282356009556	metal binding site [ion binding]; metal-binding site
1282356009557	active site
1282356009558	I-site; other site
1282356009559	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356009560	PAS domain; Region: PAS_9; pfam13426
1282356009561	putative active site [active]
1282356009562	heme pocket [chemical binding]; other site
1282356009563	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356009564	PAS domain; Region: PAS_9; pfam13426
1282356009565	putative active site [active]
1282356009566	heme pocket [chemical binding]; other site
1282356009567	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356009568	dimer interface [polypeptide binding]; other site
1282356009569	putative CheW interface [polypeptide binding]; other site
1282356009570	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356009571	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356009572	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1282356009573	dimerization interface [polypeptide binding]; other site
1282356009574	hypothetical protein; Validated; Region: PRK06186
1282356009575	conserved cys residue [active]
1282356009576	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1282356009577	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1282356009578	Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601
1282356009579	active site
1282356009580	catalytic site [active]
1282356009581	metal binding site [ion binding]; metal-binding site
1282356009582	Predicted membrane protein [Function unknown]; Region: COG3212
1282356009583	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1282356009584	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1282356009585	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356009586	dimer interface [polypeptide binding]; other site
1282356009587	phosphorylation site [posttranslational modification]
1282356009588	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356009589	ATP binding site [chemical binding]; other site
1282356009590	Mg2+ binding site [ion binding]; other site
1282356009591	G-X-G motif; other site
1282356009592	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1282356009593	Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834
1282356009594	Cl binding site [ion binding]; other site
1282356009595	oligomer interface [polypeptide binding]; other site
1282356009596	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1282356009597	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1282356009598	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
1282356009599	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
1282356009600	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
1282356009601	hypothetical protein; Provisional; Region: PRK12569
1282356009602	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356009603	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356009604	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
1282356009605	putative substrate binding pocket [chemical binding]; other site
1282356009606	dimerization interface [polypeptide binding]; other site
1282356009607	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356009608	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356009609	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
1282356009610	putative effector binding pocket; other site
1282356009611	putative dimerization interface [polypeptide binding]; other site
1282356009612	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1282356009613	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1282356009614	NAD(P) binding site [chemical binding]; other site
1282356009615	active site
1282356009616	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
1282356009617	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
1282356009618	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356009619	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356009620	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1282356009621	dimerization interface [polypeptide binding]; other site
1282356009622	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1282356009623	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
1282356009624	aminotransferase; Validated; Region: PRK08175
1282356009625	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1282356009626	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356009627	homodimer interface [polypeptide binding]; other site
1282356009628	catalytic residue [active]
1282356009629	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1282356009630	GntP family permease; Region: GntP_permease; pfam02447
1282356009631	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
1282356009632	AAA domain; Region: AAA_33; pfam13671
1282356009633	ATP-binding site [chemical binding]; other site
1282356009634	Gluconate-6-phosphate binding site [chemical binding]; other site
1282356009635	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1282356009636	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1282356009637	DNA binding site [nucleotide binding]
1282356009638	domain linker motif; other site
1282356009639	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
1282356009640	putative ligand binding site [chemical binding]; other site
1282356009641	putative dimerization interface [polypeptide binding]; other site
1282356009642	benzoate transport; Region: 2A0115; TIGR00895
1282356009643	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356009644	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356009645	putative substrate translocation pore; other site
1282356009646	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
1282356009647	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356009648	PAS domain; Region: PAS_9; pfam13426
1282356009649	putative active site [active]
1282356009650	heme pocket [chemical binding]; other site
1282356009651	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356009652	PAS domain; Region: PAS_9; pfam13426
1282356009653	putative active site [active]
1282356009654	heme pocket [chemical binding]; other site
1282356009655	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356009656	dimer interface [polypeptide binding]; other site
1282356009657	putative CheW interface [polypeptide binding]; other site
1282356009658	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1282356009659	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1282356009660	substrate binding pocket [chemical binding]; other site
1282356009661	membrane-bound complex binding site; other site
1282356009662	hinge residues; other site
1282356009663	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1282356009664	Coenzyme A binding pocket [chemical binding]; other site
1282356009665	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1282356009666	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1282356009667	active site
1282356009668	catalytic residues [active]
1282356009669	metal binding site [ion binding]; metal-binding site
1282356009670	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
1282356009671	CsbD-like; Region: CsbD; pfam05532
1282356009672	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677
1282356009673	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
1282356009674	acyl-activating enzyme (AAE) consensus motif; other site
1282356009675	putative AMP binding site [chemical binding]; other site
1282356009676	putative active site [active]
1282356009677	putative CoA binding site [chemical binding]; other site
1282356009678	long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12492
1282356009679	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1282356009680	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
1282356009681	acyl-activating enzyme (AAE) consensus motif; other site
1282356009682	putative AMP binding site [chemical binding]; other site
1282356009683	putative active site [active]
1282356009684	putative CoA binding site [chemical binding]; other site
1282356009685	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1282356009686	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1282356009687	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
1282356009688	dimer interaction site [polypeptide binding]; other site
1282356009689	substrate-binding tunnel; other site
1282356009690	active site
1282356009691	catalytic site [active]
1282356009692	substrate binding site [chemical binding]; other site
1282356009693	Domain of unknown function (DUF2383); Region: DUF2383; cl17556
1282356009694	Protein of unknown function (DUF3820); Region: DUF3820; pfam12843
1282356009695	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1282356009696	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1282356009697	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1282356009698	catalytic residue [active]
1282356009699	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
1282356009700	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1282356009701	active site
1282356009702	intersubunit interface [polypeptide binding]; other site
1282356009703	catalytic residue [active]
1282356009704	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1282356009705	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
1282356009706	putative active site [active]
1282356009707	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1282356009708	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1282356009709	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1282356009710	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
1282356009711	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1282356009712	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1282356009713	putative active site [active]
1282356009714	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
1282356009715	active site
1282356009716	phosphate binding residues; other site
1282356009717	catalytic residues [active]
1282356009718	Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659
1282356009719	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1282356009720	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1282356009721	Walker A/P-loop; other site
1282356009722	ATP binding site [chemical binding]; other site
1282356009723	Q-loop/lid; other site
1282356009724	ABC transporter signature motif; other site
1282356009725	Walker B; other site
1282356009726	D-loop; other site
1282356009727	H-loop/switch region; other site
1282356009728	TOBE domain; Region: TOBE; pfam03459
1282356009729	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1282356009730	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356009731	dimer interface [polypeptide binding]; other site
1282356009732	conserved gate region; other site
1282356009733	putative PBP binding loops; other site
1282356009734	ABC-ATPase subunit interface; other site
1282356009735	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356009736	dimer interface [polypeptide binding]; other site
1282356009737	conserved gate region; other site
1282356009738	putative PBP binding loops; other site
1282356009739	ABC-ATPase subunit interface; other site
1282356009740	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1282356009741	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1282356009742	N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221
1282356009743	putative active cleft [active]
1282356009744	dimerization interface [polypeptide binding]; other site
1282356009745	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
1282356009746	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1282356009747	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1282356009748	NAD(P) binding site [chemical binding]; other site
1282356009749	active site
1282356009750	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
1282356009751	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356009752	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1282356009753	dimerization interface [polypeptide binding]; other site
1282356009754	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602
1282356009755	ACT domain; Region: ACT_3; pfam10000
1282356009756	Family description; Region: ACT_7; pfam13840
1282356009757	Lysine efflux permease [General function prediction only]; Region: COG1279
1282356009758	superoxide dismutase; Provisional; Region: PRK10543
1282356009759	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1282356009760	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1282356009761	biofilm formation regulator HmsP; Provisional; Region: PRK11829
1282356009762	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1282356009763	metal binding site [ion binding]; metal-binding site
1282356009764	active site
1282356009765	I-site; other site
1282356009766	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1282356009767	Imelysin; Region: Peptidase_M75; cl09159
1282356009768	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1282356009769	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1282356009770	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1282356009771	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1282356009772	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1282356009773	Protein of unknown function (DUF962); Region: DUF962; pfam06127
1282356009774	major facilitator superfamily transporter; Provisional; Region: PRK05122
1282356009775	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356009776	putative substrate translocation pore; other site
1282356009777	hypothetical protein; Provisional; Region: PRK09256
1282356009778	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
1282356009779	Predicted ATPases [General function prediction only]; Region: COG1106
1282356009780	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1282356009781	Walker A/P-loop; other site
1282356009782	ATP binding site [chemical binding]; other site
1282356009783	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1282356009784	Walker B; other site
1282356009785	D-loop; other site
1282356009786	H-loop/switch region; other site
1282356009787	RloB-like protein; Region: RloB; pfam13707
1282356009788	aromatic amino acid transporter; Provisional; Region: PRK10238
1282356009789	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
1282356009790	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1282356009791	RNA binding surface [nucleotide binding]; other site
1282356009792	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
1282356009793	probable active site [active]
1282356009794	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
1282356009795	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
1282356009796	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
1282356009797	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
1282356009798	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
1282356009799	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
1282356009800	active site
1282356009801	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
1282356009802	intracellular septation protein A; Reviewed; Region: PRK00259
1282356009803	YciI-like protein; Reviewed; Region: PRK11370
1282356009804	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
1282356009805	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1282356009806	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356009807	active site
1282356009808	phosphorylation site [posttranslational modification]
1282356009809	intermolecular recognition site; other site
1282356009810	dimerization interface [polypeptide binding]; other site
1282356009811	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1282356009812	DNA binding site [nucleotide binding]
1282356009813	LTXXQ motif family protein; Region: LTXXQ; pfam07813
1282356009814	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1282356009815	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1282356009816	dimerization interface [polypeptide binding]; other site
1282356009817	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356009818	ATP binding site [chemical binding]; other site
1282356009819	Mg2+ binding site [ion binding]; other site
1282356009820	G-X-G motif; other site
1282356009821	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1282356009822	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1282356009823	Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283
1282356009824	N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877
1282356009825	putative aromatic amino acid binding site; other site
1282356009826	PAS domain; Region: PAS; smart00091
1282356009827	putative active site [active]
1282356009828	heme pocket [chemical binding]; other site
1282356009829	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356009830	Walker A motif; other site
1282356009831	ATP binding site [chemical binding]; other site
1282356009832	Walker B motif; other site
1282356009833	arginine finger; other site
1282356009834	glycine cleavage system protein H; Provisional; Region: PRK13380
1282356009835	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1282356009836	lipoyl attachment site [posttranslational modification]; other site
1282356009837	glycine dehydrogenase; Provisional; Region: PRK05367
1282356009838	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1282356009839	tetramer interface [polypeptide binding]; other site
1282356009840	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356009841	catalytic residue [active]
1282356009842	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1282356009843	tetramer interface [polypeptide binding]; other site
1282356009844	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356009845	catalytic residue [active]
1282356009846	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
1282356009847	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1282356009848	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1282356009849	DNA-binding site [nucleotide binding]; DNA binding site
1282356009850	RNA-binding motif; other site
1282356009851	RDD family; Region: RDD; pfam06271
1282356009852	quinolinate synthetase; Provisional; Region: PRK09375
1282356009853	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349
1282356009854	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1282356009855	FeS/SAM binding site; other site
1282356009856	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
1282356009857	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1282356009858	binding surface
1282356009859	TPR motif; other site
1282356009860	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1282356009861	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1282356009862	ligand binding site [chemical binding]; other site
1282356009863	translocation protein TolB; Provisional; Region: tolB; PRK00178
1282356009864	TolB amino-terminal domain; Region: TolB_N; pfam04052
1282356009865	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1282356009866	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1282356009867	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1282356009868	TolA protein; Region: tolA_full; TIGR02794
1282356009869	TolA protein; Region: tolA_full; TIGR02794
1282356009870	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
1282356009871	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1282356009872	TolR protein; Region: tolR; TIGR02801
1282356009873	TolQ protein; Region: tolQ; TIGR02796
1282356009874	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1282356009875	active site
1282356009876	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1282356009877	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356009878	Walker A motif; other site
1282356009879	ATP binding site [chemical binding]; other site
1282356009880	Walker B motif; other site
1282356009881	arginine finger; other site
1282356009882	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1282356009883	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1282356009884	RuvA N terminal domain; Region: RuvA_N; pfam01330
1282356009885	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
1282356009886	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1282356009887	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
1282356009888	active site
1282356009889	putative DNA-binding cleft [nucleotide binding]; other site
1282356009890	dimer interface [polypeptide binding]; other site
1282356009891	hypothetical protein; Validated; Region: PRK00110
1282356009892	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1282356009893	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1282356009894	dimer interface [polypeptide binding]; other site
1282356009895	anticodon binding site; other site
1282356009896	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1282356009897	homodimer interface [polypeptide binding]; other site
1282356009898	motif 1; other site
1282356009899	active site
1282356009900	motif 2; other site
1282356009901	GAD domain; Region: GAD; pfam02938
1282356009902	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1282356009903	active site
1282356009904	motif 3; other site
1282356009905	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
1282356009906	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
1282356009907	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1282356009908	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1282356009909	dimerization interface [polypeptide binding]; other site
1282356009910	DPS ferroxidase diiron center [ion binding]; other site
1282356009911	ion pore; other site
1282356009912	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1282356009913	DNA-binding site [nucleotide binding]; DNA binding site
1282356009914	RNA-binding motif; other site
1282356009915	hypothetical protein; Provisional; Region: PRK00295
1282356009916	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
1282356009917	outer membrane porin, OprD family; Region: OprD; pfam03573
1282356009918	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1282356009919	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1282356009920	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
1282356009921	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
1282356009922	2-dehydropantoate 2-reductase; Provisional; Region: PRK05708
1282356009923	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1282356009924	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1282356009925	HAMP domain; Region: HAMP; pfam00672
1282356009926	dimerization interface [polypeptide binding]; other site
1282356009927	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1282356009928	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356009929	putative active site [active]
1282356009930	heme pocket [chemical binding]; other site
1282356009931	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356009932	dimer interface [polypeptide binding]; other site
1282356009933	phosphorylation site [posttranslational modification]
1282356009934	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356009935	ATP binding site [chemical binding]; other site
1282356009936	Mg2+ binding site [ion binding]; other site
1282356009937	G-X-G motif; other site
1282356009938	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
1282356009939	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1282356009940	MULE transposase domain; Region: MULE; pfam10551
1282356009941	hypothetical protein; Provisional; Region: PRK08999
1282356009942	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
1282356009943	active site
1282356009944	8-oxo-dGMP binding site [chemical binding]; other site
1282356009945	nudix motif; other site
1282356009946	metal binding site [ion binding]; metal-binding site
1282356009947	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1282356009948	thiamine phosphate binding site [chemical binding]; other site
1282356009949	active site
1282356009950	pyrophosphate binding site [ion binding]; other site
1282356009951	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
1282356009952	heterotetramer interface [polypeptide binding]; other site
1282356009953	active site pocket [active]
1282356009954	cleavage site
1282356009955	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK13103
1282356009956	DEAD/DEAH box helicase; Region: DEAD; pfam00270
1282356009957	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1282356009958	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
1282356009959	nucleotide binding region [chemical binding]; other site
1282356009960	ATP-binding site [chemical binding]; other site
1282356009961	SEC-C motif; Region: SEC-C; pfam02810
1282356009962	Protein of unknown function (DUF721); Region: DUF721; pfam05258
1282356009963	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
1282356009964	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
1282356009965	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
1282356009966	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
1282356009967	putative active site [active]
1282356009968	putative substrate binding site [chemical binding]; other site
1282356009969	putative cosubstrate binding site; other site
1282356009970	catalytic site [active]
1282356009971	exonuclease I; Provisional; Region: sbcB; PRK11779
1282356009972	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
1282356009973	active site
1282356009974	catalytic site [active]
1282356009975	substrate binding site [chemical binding]; other site
1282356009976	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
1282356009977	RDD family; Region: RDD; pfam06271
1282356009978	Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300
1282356009979	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
1282356009980	MoxR-like ATPases [General function prediction only]; Region: COG0714
1282356009981	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356009982	Walker A motif; other site
1282356009983	ATP binding site [chemical binding]; other site
1282356009984	Walker B motif; other site
1282356009985	arginine finger; other site
1282356009986	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1282356009987	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1282356009988	metal ion-dependent adhesion site (MIDAS); other site
1282356009989	PilZ domain; Region: PilZ; pfam07238
1282356009990	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
1282356009991	pyruvate kinase; Provisional; Region: PRK05826
1282356009992	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1282356009993	domain interfaces; other site
1282356009994	active site
1282356009995	hypothetical protein; Provisional; Region: PRK05713
1282356009996	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1282356009997	catalytic loop [active]
1282356009998	iron binding site [ion binding]; other site
1282356009999	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194
1282356010000	FAD binding pocket [chemical binding]; other site
1282356010001	FAD binding motif [chemical binding]; other site
1282356010002	phosphate binding motif [ion binding]; other site
1282356010003	beta-alpha-beta structure motif; other site
1282356010004	NAD binding pocket [chemical binding]; other site
1282356010005	putative fumarate hydratase; Provisional; Region: PRK15392
1282356010006	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
1282356010007	Fumarase C-terminus; Region: Fumerase_C; pfam05683
1282356010008	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
1282356010009	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356010010	dimer interface [polypeptide binding]; other site
1282356010011	phosphorylation site [posttranslational modification]
1282356010012	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356010013	ATP binding site [chemical binding]; other site
1282356010014	Mg2+ binding site [ion binding]; other site
1282356010015	G-X-G motif; other site
1282356010016	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1282356010017	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356010018	active site
1282356010019	phosphorylation site [posttranslational modification]
1282356010020	intermolecular recognition site; other site
1282356010021	dimerization interface [polypeptide binding]; other site
1282356010022	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356010023	Walker A motif; other site
1282356010024	ATP binding site [chemical binding]; other site
1282356010025	Walker B motif; other site
1282356010026	arginine finger; other site
1282356010027	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
1282356010028	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
1282356010029	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356010030	putative substrate translocation pore; other site
1282356010031	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1282356010032	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1282356010033	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
1282356010034	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1282356010035	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1282356010036	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1282356010037	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356010038	ATP binding site [chemical binding]; other site
1282356010039	Mg2+ binding site [ion binding]; other site
1282356010040	G-X-G motif; other site
1282356010041	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1282356010042	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356010043	active site
1282356010044	phosphorylation site [posttranslational modification]
1282356010045	intermolecular recognition site; other site
1282356010046	dimerization interface [polypeptide binding]; other site
1282356010047	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1282356010048	DNA binding site [nucleotide binding]
1282356010049	glucokinase, proteobacterial type; Region: glk; TIGR00749
1282356010050	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1282356010051	nucleotide binding site [chemical binding]; other site
1282356010052	phosphogluconate dehydratase; Validated; Region: PRK09054
1282356010053	6-phosphogluconate dehydratase; Region: edd; TIGR01196
1282356010054	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
1282356010055	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1282356010056	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1282356010057	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1282356010058	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1282356010059	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1282356010060	DNA binding residues [nucleotide binding]
1282356010061	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
1282356010062	FecR protein; Region: FecR; pfam04773
1282356010063	Secretin and TonB N terminus short domain; Region: STN; smart00965
1282356010064	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
1282356010065	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1282356010066	N-terminal plug; other site
1282356010067	ligand-binding site [chemical binding]; other site
1282356010068	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
1282356010069	heme binding pocket [chemical binding]; other site
1282356010070	heme ligand [chemical binding]; other site
1282356010071	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
1282356010072	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1282356010073	dimerization interface [polypeptide binding]; other site
1282356010074	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1282356010075	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356010076	dimer interface [polypeptide binding]; other site
1282356010077	putative CheW interface [polypeptide binding]; other site
1282356010078	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
1282356010079	putative FMN binding site [chemical binding]; other site
1282356010080	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
1282356010081	Protein of unknown function (DUF1111); Region: DUF1111; pfam06537
1282356010082	Imelysin; Region: Peptidase_M75; cl09159
1282356010083	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3490
1282356010084	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
1282356010085	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356010086	S-adenosylmethionine binding site [chemical binding]; other site
1282356010087	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1282356010088	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356010089	dimer interface [polypeptide binding]; other site
1282356010090	phosphorylation site [posttranslational modification]
1282356010091	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356010092	ATP binding site [chemical binding]; other site
1282356010093	Mg2+ binding site [ion binding]; other site
1282356010094	G-X-G motif; other site
1282356010095	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1282356010096	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356010097	active site
1282356010098	phosphorylation site [posttranslational modification]
1282356010099	intermolecular recognition site; other site
1282356010100	dimerization interface [polypeptide binding]; other site
1282356010101	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1282356010102	DNA binding site [nucleotide binding]
1282356010103	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1282356010104	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1282356010105	ring oligomerisation interface [polypeptide binding]; other site
1282356010106	ATP/Mg binding site [chemical binding]; other site
1282356010107	stacking interactions; other site
1282356010108	hinge regions; other site
1282356010109	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1282356010110	oligomerisation interface [polypeptide binding]; other site
1282356010111	mobile loop; other site
1282356010112	roof hairpin; other site
1282356010113	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
1282356010114	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
1282356010115	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
1282356010116	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
1282356010117	Sm and related proteins; Region: Sm_like; cl00259
1282356010118	Sm1 motif; other site
1282356010119	Protein of unknown function, DUF481; Region: DUF481; pfam04338
1282356010120	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1282356010121	DNA binding site [nucleotide binding]
1282356010122	active site
1282356010123	muropeptide transporter; Validated; Region: ampG; cl17669
1282356010124	muropeptide transporter; Validated; Region: ampG; cl17669
1282356010125	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1282356010126	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1282356010127	dimer interface [polypeptide binding]; other site
1282356010128	motif 1; other site
1282356010129	active site
1282356010130	motif 2; other site
1282356010131	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1282356010132	putative deacylase active site [active]
1282356010133	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1282356010134	active site
1282356010135	motif 3; other site
1282356010136	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1282356010137	anticodon binding site; other site
1282356010138	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1282356010139	active site
1282356010140	DNA polymerase IV; Validated; Region: PRK02406
1282356010141	DNA binding site [nucleotide binding]
1282356010142	Predicted integral membrane protein [Function unknown]; Region: COG0392
1282356010143	Uncharacterized conserved protein [Function unknown]; Region: COG2898
1282356010144	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1282356010145	Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946
1282356010146	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
1282356010147	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
1282356010148	DHH family; Region: DHH; pfam01368
1282356010149	DHHA1 domain; Region: DHHA1; pfam02272
1282356010150	YaeQ protein; Region: YaeQ; pfam07152
1282356010151	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1282356010152	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1282356010153	Protein of unknown function (DUF3509); Region: DUF3509; pfam12021
1282356010154	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
1282356010155	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
1282356010156	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356010157	catalytic residue [active]
1282356010158	homoserine dehydrogenase; Provisional; Region: PRK06349
1282356010159	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1282356010160	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1282356010161	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
1282356010162	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
1282356010163	dimerization domain [polypeptide binding]; other site
1282356010164	dimer interface [polypeptide binding]; other site
1282356010165	catalytic residues [active]
1282356010166	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
1282356010167	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1282356010168	active site
1282356010169	Int/Topo IB signature motif; other site
1282356010170	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1282356010171	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1282356010172	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1282356010173	RimM N-terminal domain; Region: RimM; pfam01782
1282356010174	PRC-barrel domain; Region: PRC; pfam05239
1282356010175	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
1282356010176	signal recognition particle protein; Provisional; Region: PRK10867
1282356010177	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1282356010178	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1282356010179	P loop; other site
1282356010180	GTP binding site [chemical binding]; other site
1282356010181	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1282356010182	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137
1282356010183	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
1282356010184	Domain of unknown function DUF21; Region: DUF21; pfam01595
1282356010185	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1282356010186	Transporter associated domain; Region: CorC_HlyC; smart01091
1282356010187	metabolite-proton symporter; Region: 2A0106; TIGR00883
1282356010188	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356010189	putative substrate translocation pore; other site
1282356010190	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
1282356010191	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1282356010192	ATP-grasp domain; Region: ATP-grasp; pfam02222
1282356010193	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
1282356010194	Predicted Fe-S protein [General function prediction only]; Region: COG3313
1282356010195	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1282356010196	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
1282356010197	trimer interface [polypeptide binding]; other site
1282356010198	putative metal binding site [ion binding]; other site
1282356010199	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
1282356010200	putative active site [active]
1282356010201	putative CoA binding site [chemical binding]; other site
1282356010202	nudix motif; other site
1282356010203	metal binding site [ion binding]; metal-binding site
1282356010204	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
1282356010205	nudix motif; other site
1282356010206	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1282356010207	potential frameshift: common BLAST hit: gi|229592410|ref|YP_002874529.1| GntR family transcriptional regulator
1282356010208	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1282356010209	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1282356010210	active site
1282356010211	dimer interface [polypeptide binding]; other site
1282356010212	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
1282356010213	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1282356010214	dimer interface [polypeptide binding]; other site
1282356010215	active site
1282356010216	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1282356010217	dimer interface [polypeptide binding]; other site
1282356010218	active site
1282356010219	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1282356010220	HPr interaction site; other site
1282356010221	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1282356010222	active site
1282356010223	phosphorylation site [posttranslational modification]
1282356010224	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1282356010225	dimerization domain swap beta strand [polypeptide binding]; other site
1282356010226	regulatory protein interface [polypeptide binding]; other site
1282356010227	active site
1282356010228	regulatory phosphorylation site [posttranslational modification]; other site
1282356010229	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1282356010230	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1282356010231	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1282356010232	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1282356010233	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1282356010234	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
1282356010235	PTS system, glucose-like IIB component; Region: EIIB_glc; TIGR00826
1282356010236	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1282356010237	active site turn [active]
1282356010238	phosphorylation site [posttranslational modification]
1282356010239	phosphotransferase system, EIIB; Region: PTS_EIIB; pfam00367
1282356010240	active site turn [active]
1282356010241	phosphorylation site [posttranslational modification]
1282356010242	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
1282356010243	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
1282356010244	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1282356010245	dimerization interface [polypeptide binding]; other site
1282356010246	ATP binding site [chemical binding]; other site
1282356010247	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1282356010248	dimerization interface [polypeptide binding]; other site
1282356010249	ATP binding site [chemical binding]; other site
1282356010250	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1282356010251	putative active site [active]
1282356010252	catalytic triad [active]
1282356010253	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
1282356010254	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1282356010255	substrate binding pocket [chemical binding]; other site
1282356010256	membrane-bound complex binding site; other site
1282356010257	hinge residues; other site
1282356010258	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1282356010259	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1282356010260	catalytic residue [active]
1282356010261	PTS system, glucose-like IIB component; Region: EIIB_glc; TIGR00826
1282356010262	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164
1282356010263	active site turn [active]
1282356010264	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1282356010265	HPr interaction site; other site
1282356010266	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1282356010267	active site
1282356010268	phosphorylation site [posttranslational modification]
1282356010269	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1282356010270	dimerization domain swap beta strand [polypeptide binding]; other site
1282356010271	regulatory protein interface [polypeptide binding]; other site
1282356010272	active site
1282356010273	regulatory phosphorylation site [posttranslational modification]; other site
1282356010274	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1282356010275	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1282356010276	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1282356010277	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1282356010278	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
1282356010279	trimer interface; other site
1282356010280	sugar binding site [chemical binding]; other site
1282356010281	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1282356010282	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1282356010283	Ca binding site [ion binding]; other site
1282356010284	active site
1282356010285	catalytic site [active]
1282356010286	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
1282356010287	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1282356010288	active site turn [active]
1282356010289	phosphorylation site [posttranslational modification]
1282356010290	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1282356010291	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1282356010292	DNA-binding site [nucleotide binding]; DNA binding site
1282356010293	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
1282356010294	UTRA domain; Region: UTRA; pfam07702
1282356010295	Fic/DOC family; Region: Fic; pfam02661
1282356010296	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
1282356010297	putative metal binding site [ion binding]; other site
1282356010298	Autotransporter beta-domain; Region: Autotransporter; pfam03797
1282356010299	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
1282356010300	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
1282356010301	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
1282356010302	RTX toxin acyltransferase family; Region: HlyC; cl01131
1282356010303	haemagglutination activity domain; Region: Haemagg_act; pfam05860
1282356010304	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
1282356010305	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1282356010306	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1282356010307	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1282356010308	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1282356010309	Domain of unknown function (DUF1910); Region: DUF1910; pfam08928
1282356010310	Domain of unknown function (DUF1911); Region: DUF1911; pfam08929
1282356010311	GMP synthase; Reviewed; Region: guaA; PRK00074
1282356010312	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1282356010313	AMP/PPi binding site [chemical binding]; other site
1282356010314	candidate oxyanion hole; other site
1282356010315	catalytic triad [active]
1282356010316	potential glutamine specificity residues [chemical binding]; other site
1282356010317	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1282356010318	ATP Binding subdomain [chemical binding]; other site
1282356010319	Ligand Binding sites [chemical binding]; other site
1282356010320	Dimerization subdomain; other site
1282356010321	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1282356010322	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1282356010323	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1282356010324	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1282356010325	active site
1282356010326	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1282356010327	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1282356010328	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1282356010329	generic binding surface II; other site
1282356010330	generic binding surface I; other site
1282356010331	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1282356010332	Peptidase family M23; Region: Peptidase_M23; pfam01551
1282356010333	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1282356010334	Alpha amylase catalytic domain family; Region: AmyAc_family; cd00551
1282356010335	2-isopropylmalate synthase; Validated; Region: PRK03739
1282356010336	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
1282356010337	active site
1282356010338	catalytic residues [active]
1282356010339	metal binding site [ion binding]; metal-binding site
1282356010340	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1282356010341	C-N hydrolase family amidase; Provisional; Region: PRK10438
1282356010342	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
1282356010343	putative active site [active]
1282356010344	catalytic triad [active]
1282356010345	dimer interface [polypeptide binding]; other site
1282356010346	multimer interface [polypeptide binding]; other site
1282356010347	methionine aminotransferase; Validated; Region: PRK09082
1282356010348	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1282356010349	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356010350	homodimer interface [polypeptide binding]; other site
1282356010351	catalytic residue [active]
1282356010352	GTP-binding protein Der; Reviewed; Region: PRK00093
1282356010353	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1282356010354	G1 box; other site
1282356010355	GTP/Mg2+ binding site [chemical binding]; other site
1282356010356	Switch I region; other site
1282356010357	G2 box; other site
1282356010358	Switch II region; other site
1282356010359	G3 box; other site
1282356010360	G4 box; other site
1282356010361	G5 box; other site
1282356010362	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1282356010363	G1 box; other site
1282356010364	GTP/Mg2+ binding site [chemical binding]; other site
1282356010365	Switch I region; other site
1282356010366	G2 box; other site
1282356010367	G3 box; other site
1282356010368	Switch II region; other site
1282356010369	G4 box; other site
1282356010370	G5 box; other site
1282356010371	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
1282356010372	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
1282356010373	Trp docking motif [polypeptide binding]; other site
1282356010374	active site
1282356010375	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
1282356010376	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
1282356010377	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1282356010378	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1282356010379	dimer interface [polypeptide binding]; other site
1282356010380	motif 1; other site
1282356010381	active site
1282356010382	motif 2; other site
1282356010383	motif 3; other site
1282356010384	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1282356010385	anticodon binding site; other site
1282356010386	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
1282356010387	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1282356010388	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1282356010389	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
1282356010390	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1282356010391	non-specific DNA binding site [nucleotide binding]; other site
1282356010392	salt bridge; other site
1282356010393	sequence-specific DNA binding site [nucleotide binding]; other site
1282356010394	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
1282356010395	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
1282356010396	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1282356010397	binding surface
1282356010398	TPR motif; other site
1282356010399	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
1282356010400	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1282356010401	FeS/SAM binding site; other site
1282356010402	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1282356010403	active site
1282356010404	multimer interface [polypeptide binding]; other site
1282356010405	Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384
1282356010406	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1282356010407	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1282356010408	catalytic loop [active]
1282356010409	iron binding site [ion binding]; other site
1282356010410	chaperone protein HscA; Provisional; Region: hscA; PRK05183
1282356010411	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
1282356010412	nucleotide binding site [chemical binding]; other site
1282356010413	putative NEF/HSP70 interaction site [polypeptide binding]; other site
1282356010414	SBD interface [polypeptide binding]; other site
1282356010415	co-chaperone HscB; Provisional; Region: hscB; PRK00294
1282356010416	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1282356010417	HSP70 interaction site [polypeptide binding]; other site
1282356010418	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
1282356010419	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
1282356010420	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1282356010421	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1282356010422	trimerization site [polypeptide binding]; other site
1282356010423	active site
1282356010424	cysteine desulfurase; Provisional; Region: PRK14012
1282356010425	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1282356010426	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1282356010427	catalytic residue [active]
1282356010428	iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010
1282356010429	Rrf2 family protein; Region: rrf2_super; TIGR00738
1282356010430	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
1282356010431	serine O-acetyltransferase; Region: cysE; TIGR01172
1282356010432	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1282356010433	trimer interface [polypeptide binding]; other site
1282356010434	active site
1282356010435	substrate binding site [chemical binding]; other site
1282356010436	CoA binding site [chemical binding]; other site
1282356010437	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
1282356010438	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1282356010439	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1282356010440	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
1282356010441	active site
1282356010442	dimerization interface [polypeptide binding]; other site
1282356010443	hypothetical protein; Provisional; Region: PRK11280
1282356010444	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
1282356010445	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
1282356010446	Protein export membrane protein; Region: SecD_SecF; pfam02355
1282356010447	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
1282356010448	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
1282356010449	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
1282356010450	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
1282356010451	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
1282356010452	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1282356010453	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1282356010454	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1282356010455	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1282356010456	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1282356010457	S-type Pyocin; Region: Pyocin_S; pfam06958
1282356010458	Cytotoxic; Region: Cytotoxic; pfam09000
1282356010459	Cloacin immunity protein; Region: Cloacin_immun; pfam03513
1282356010460	Protein of unknown function (DUF3916); Region: DUF3916; pfam13079
1282356010461	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1282356010462	Mg2+ binding site [ion binding]; other site
1282356010463	RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when...; Region: RhoGAP; cl02570
1282356010464	GTPase interaction site; other site
1282356010465	Cytochrome c2 [Energy production and conversion]; Region: COG3474
1282356010466	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1282356010467	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356010468	active site
1282356010469	phosphorylation site [posttranslational modification]
1282356010470	intermolecular recognition site; other site
1282356010471	dimerization interface [polypeptide binding]; other site
1282356010472	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
1282356010473	heme binding pocket [chemical binding]; other site
1282356010474	heme ligand [chemical binding]; other site
1282356010475	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
1282356010476	GAF domain; Region: GAF; pfam01590
1282356010477	Phytochrome region; Region: PHY; pfam00360
1282356010478	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356010479	dimer interface [polypeptide binding]; other site
1282356010480	phosphorylation site [posttranslational modification]
1282356010481	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356010482	ATP binding site [chemical binding]; other site
1282356010483	Mg2+ binding site [ion binding]; other site
1282356010484	G-X-G motif; other site
1282356010485	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1282356010486	metal binding site [ion binding]; metal-binding site
1282356010487	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
1282356010488	putative active site [active]
1282356010489	putative metal binding site [ion binding]; other site
1282356010490	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356010491	PAS fold; Region: PAS_3; pfam08447
1282356010492	putative active site [active]
1282356010493	heme pocket [chemical binding]; other site
1282356010494	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1282356010495	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1282356010496	metal binding site [ion binding]; metal-binding site
1282356010497	active site
1282356010498	I-site; other site
1282356010499	putative aminotransferase; Provisional; Region: PRK09105
1282356010500	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1282356010501	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356010502	homodimer interface [polypeptide binding]; other site
1282356010503	catalytic residue [active]
1282356010504	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
1282356010505	Ligand Binding Site [chemical binding]; other site
1282356010506	protoheme IX farnesyltransferase; Provisional; Region: PRK13362
1282356010507	UbiA prenyltransferase family; Region: UbiA; pfam01040
1282356010508	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
1282356010509	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
1282356010510	Subunit I/III interface [polypeptide binding]; other site
1282356010511	Subunit III/IV interface [polypeptide binding]; other site
1282356010512	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1282356010513	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1282356010514	D-pathway; other site
1282356010515	Putative ubiquinol binding site [chemical binding]; other site
1282356010516	Low-spin heme (heme b) binding site [chemical binding]; other site
1282356010517	Putative water exit pathway; other site
1282356010518	Binuclear center (heme o3/CuB) [ion binding]; other site
1282356010519	K-pathway; other site
1282356010520	Putative proton exit pathway; other site
1282356010521	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
1282356010522	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1282356010523	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
1282356010524	disulfide bond formation protein B; Provisional; Region: PRK02110
1282356010525	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
1282356010526	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
1282356010527	heme-binding site [chemical binding]; other site
1282356010528	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
1282356010529	FAD binding pocket [chemical binding]; other site
1282356010530	FAD binding motif [chemical binding]; other site
1282356010531	phosphate binding motif [ion binding]; other site
1282356010532	beta-alpha-beta structure motif; other site
1282356010533	NAD binding pocket [chemical binding]; other site
1282356010534	Heme binding  pocket [chemical binding]; other site
1282356010535	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
1282356010536	GAF domain; Region: GAF; pfam01590
1282356010537	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356010538	Walker A motif; other site
1282356010539	ATP binding site [chemical binding]; other site
1282356010540	Walker B motif; other site
1282356010541	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1282356010542	EamA-like transporter family; Region: EamA; pfam00892
1282356010543	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1282356010544	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1282356010545	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
1282356010546	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1282356010547	DNA binding residues [nucleotide binding]
1282356010548	dimerization interface [polypeptide binding]; other site
1282356010549	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
1282356010550	Protein of unknown function (DUF1302); Region: DUF1302; pfam06980
1282356010551	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
1282356010552	homodimer interface [polypeptide binding]; other site
1282356010553	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1282356010554	NAD binding site [chemical binding]; other site
1282356010555	active site
1282356010556	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1282356010557	flavodoxin; Provisional; Region: PRK05723
1282356010558	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356010559	PAS domain; Region: PAS_9; pfam13426
1282356010560	putative active site [active]
1282356010561	heme pocket [chemical binding]; other site
1282356010562	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
1282356010563	DNA binding residues [nucleotide binding]
1282356010564	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1282356010565	B12 binding domain; Region: B12-binding_2; cl03653
1282356010566	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
1282356010567	dihydromonapterin reductase; Provisional; Region: PRK06483
1282356010568	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1282356010569	NAD(P) binding site [chemical binding]; other site
1282356010570	active site
1282356010571	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
1282356010572	homodecamer interface [polypeptide binding]; other site
1282356010573	GTP cyclohydrolase I; Provisional; Region: PLN03044
1282356010574	active site
1282356010575	putative catalytic site residues [active]
1282356010576	zinc binding site [ion binding]; other site
1282356010577	GTP-CH-I/GFRP interaction surface; other site
1282356010578	D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase; Provisional; Region: folX; PRK11245
1282356010579	active site
1282356010580	Protein of unknown function (DUF1244); Region: DUF1244; cl01385
1282356010581	HopJ type III effector protein; Region: HopJ; pfam08888
1282356010582	thioredoxin reductase; Provisional; Region: PRK10262
1282356010583	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1282356010584	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1282356010585	putative sulfate transport protein CysZ; Validated; Region: PRK04949
1282356010586	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1282356010587	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
1282356010588	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1282356010589	Old yellow enzyme (OYE)-related FMN binding domain, group 5.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747
1282356010590	putative active site [active]
1282356010591	putative FMN binding site [chemical binding]; other site
1282356010592	putative substrate binding site [chemical binding]; other site
1282356010593	putative catalytic residue [active]
1282356010594	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1282356010595	catalytic residues [active]
1282356010596	dimer interface [polypeptide binding]; other site
1282356010597	CreA protein; Region: CreA; pfam05981
1282356010598	gamma-glutamyl kinase; Provisional; Region: PRK05429
1282356010599	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1282356010600	nucleotide binding site [chemical binding]; other site
1282356010601	homotetrameric interface [polypeptide binding]; other site
1282356010602	putative phosphate binding site [ion binding]; other site
1282356010603	putative allosteric binding site; other site
1282356010604	PUA domain; Region: PUA; pfam01472
1282356010605	GTPase CgtA; Reviewed; Region: obgE; PRK12298
1282356010606	GTP1/OBG; Region: GTP1_OBG; pfam01018
1282356010607	Obg GTPase; Region: Obg; cd01898
1282356010608	G1 box; other site
1282356010609	GTP/Mg2+ binding site [chemical binding]; other site
1282356010610	Switch I region; other site
1282356010611	G2 box; other site
1282356010612	G3 box; other site
1282356010613	Switch II region; other site
1282356010614	G4 box; other site
1282356010615	G5 box; other site
1282356010616	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1282356010617	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1282356010618	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1282356010619	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1282356010620	substrate binding pocket [chemical binding]; other site
1282356010621	chain length determination region; other site
1282356010622	substrate-Mg2+ binding site; other site
1282356010623	catalytic residues [active]
1282356010624	aspartate-rich region 1; other site
1282356010625	active site lid residues [active]
1282356010626	aspartate-rich region 2; other site
1282356010627	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
1282356010628	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
1282356010629	PhnA protein; Region: PhnA; pfam03831
1282356010630	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
1282356010631	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
1282356010632	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1282356010633	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1282356010634	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1282356010635	dimerization interface [polypeptide binding]; other site
1282356010636	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1282356010637	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356010638	dimer interface [polypeptide binding]; other site
1282356010639	putative CheW interface [polypeptide binding]; other site
1282356010640	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
1282356010641	dimer interface [polypeptide binding]; other site
1282356010642	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1282356010643	ligand binding site [chemical binding]; other site
1282356010644	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755
1282356010645	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1282356010646	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1282356010647	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1282356010648	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1282356010649	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356010650	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356010651	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1282356010652	dimerization interface [polypeptide binding]; other site
1282356010653	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
1282356010654	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1282356010655	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356010656	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356010657	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
1282356010658	putative dimerization interface [polypeptide binding]; other site
1282356010659	aromatic amino acid transporter; Provisional; Region: PRK10238
1282356010660	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
1282356010661	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1282356010662	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
1282356010663	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1282356010664	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
1282356010665	tetrameric interface [polypeptide binding]; other site
1282356010666	NAD binding site [chemical binding]; other site
1282356010667	catalytic residues [active]
1282356010668	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356010669	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356010670	LysR substrate binding domain; Region: LysR_substrate; pfam03466
1282356010671	dimerization interface [polypeptide binding]; other site
1282356010672	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
1282356010673	AAA domain; Region: AAA_30; pfam13604
1282356010674	Family description; Region: UvrD_C_2; pfam13538
1282356010675	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
1282356010676	Family description; Region: UvrD_C_2; pfam13538
1282356010677	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
1282356010678	exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
1282356010679	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
1282356010680	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
1282356010681	active site
1282356010682	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1282356010683	Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625
1282356010684	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
1282356010685	Autotransporter beta-domain; Region: Autotransporter; pfam03797
1282356010686	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
1282356010687	TMAO/DMSO reductase; Reviewed; Region: PRK05363
1282356010688	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1282356010689	Moco binding site; other site
1282356010690	metal coordination site [ion binding]; other site
1282356010691	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
1282356010692	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
1282356010693	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1282356010694	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1282356010695	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1282356010696	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
1282356010697	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1282356010698	putative valine binding site [chemical binding]; other site
1282356010699	dimer interface [polypeptide binding]; other site
1282356010700	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1282356010701	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466
1282356010702	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1282356010703	PYR/PP interface [polypeptide binding]; other site
1282356010704	dimer interface [polypeptide binding]; other site
1282356010705	TPP binding site [chemical binding]; other site
1282356010706	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1282356010707	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1282356010708	TPP-binding site [chemical binding]; other site
1282356010709	dimer interface [polypeptide binding]; other site
1282356010710	tRNA pseudouridine synthase C; Region: DUF446; pfam04287
1282356010711	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1282356010712	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1282356010713	TPR motif; other site
1282356010714	penicillin-binding protein 1B; Region: PBP_1b; TIGR02071
1282356010715	Transglycosylase; Region: Transgly; pfam00912
1282356010716	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1282356010717	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
1282356010718	AAA domain; Region: AAA_33; pfam13671
1282356010719	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1282356010720	active site
1282356010721	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1282356010722	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1282356010723	TfoX C-terminal domain; Region: TfoX_C; pfam04994
1282356010724	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
1282356010725	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1282356010726	Walker A/P-loop; other site
1282356010727	ATP binding site [chemical binding]; other site
1282356010728	Q-loop/lid; other site
1282356010729	ABC transporter signature motif; other site
1282356010730	Walker B; other site
1282356010731	D-loop; other site
1282356010732	H-loop/switch region; other site
1282356010733	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1282356010734	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1282356010735	ABC-ATPase subunit  interface; other site
1282356010736	dimer interface [polypeptide binding]; other site
1282356010737	putative PBP binding regions; other site
1282356010738	ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558
1282356010739	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1282356010740	intersubunit interface [polypeptide binding]; other site
1282356010741	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
1282356010742	iron-sulfur cluster [ion binding]; other site
1282356010743	[2Fe-2S] cluster binding site [ion binding]; other site
1282356010744	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
1282356010745	hypothetical protein; Provisional; Region: PRK08960
1282356010746	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1282356010747	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356010748	homodimer interface [polypeptide binding]; other site
1282356010749	catalytic residue [active]
1282356010750	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
1282356010751	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
1282356010752	Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008
1282356010753	active site
1282356010754	nucleotide binding site [chemical binding]; other site
1282356010755	HIGH motif; other site
1282356010756	KMSKS motif; other site
1282356010757	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
1282356010758	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1282356010759	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356010760	putative active site [active]
1282356010761	heme pocket [chemical binding]; other site
1282356010762	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356010763	dimer interface [polypeptide binding]; other site
1282356010764	phosphorylation site [posttranslational modification]
1282356010765	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356010766	ATP binding site [chemical binding]; other site
1282356010767	Mg2+ binding site [ion binding]; other site
1282356010768	G-X-G motif; other site
1282356010769	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1282356010770	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356010771	active site
1282356010772	phosphorylation site [posttranslational modification]
1282356010773	intermolecular recognition site; other site
1282356010774	dimerization interface [polypeptide binding]; other site
1282356010775	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356010776	Walker A motif; other site
1282356010777	ATP binding site [chemical binding]; other site
1282356010778	Walker B motif; other site
1282356010779	arginine finger; other site
1282356010780	poly(A) polymerase; Region: pcnB; TIGR01942
1282356010781	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1282356010782	active site
1282356010783	NTP binding site [chemical binding]; other site
1282356010784	metal binding triad [ion binding]; metal-binding site
1282356010785	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1282356010786	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
1282356010787	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1282356010788	catalytic center binding site [active]
1282356010789	ATP binding site [chemical binding]; other site
1282356010790	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1282356010791	oligomerization interface [polypeptide binding]; other site
1282356010792	active site
1282356010793	metal binding site [ion binding]; metal-binding site
1282356010794	Pantoate-beta-alanine ligase; Region: PanC; cd00560
1282356010795	pantoate--beta-alanine ligase; Region: panC; TIGR00018
1282356010796	active site
1282356010797	ATP-binding site [chemical binding]; other site
1282356010798	pantoate-binding site; other site
1282356010799	HXXH motif; other site
1282356010800	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
1282356010801	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1282356010802	active site
1282356010803	dimer interface [polypeptide binding]; other site
1282356010804	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1282356010805	dimer interface [polypeptide binding]; other site
1282356010806	active site
1282356010807	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
1282356010808	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
1282356010809	putative RNA binding site [nucleotide binding]; other site
1282356010810	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1282356010811	S-adenosylmethionine binding site [chemical binding]; other site
1282356010812	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
1282356010813	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
1282356010814	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
1282356010815	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
1282356010816	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
1282356010817	BON domain; Region: BON; pfam04972
1282356010818	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
1282356010819	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
1282356010820	RNase E interface [polypeptide binding]; other site
1282356010821	trimer interface [polypeptide binding]; other site
1282356010822	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1282356010823	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1282356010824	RNase E interface [polypeptide binding]; other site
1282356010825	trimer interface [polypeptide binding]; other site
1282356010826	active site
1282356010827	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1282356010828	putative nucleic acid binding region [nucleotide binding]; other site
1282356010829	G-X-X-G motif; other site
1282356010830	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1282356010831	RNA binding site [nucleotide binding]; other site
1282356010832	domain interface; other site
1282356010833	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1282356010834	16S/18S rRNA binding site [nucleotide binding]; other site
1282356010835	S13e-L30e interaction site [polypeptide binding]; other site
1282356010836	25S rRNA binding site [nucleotide binding]; other site
1282356010837	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
1282356010838	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1282356010839	RNA binding site [nucleotide binding]; other site
1282356010840	active site
1282356010841	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
1282356010842	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1282356010843	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
1282356010844	translation initiation factor IF-2; Region: IF-2; TIGR00487
1282356010845	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1282356010846	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1282356010847	G1 box; other site
1282356010848	putative GEF interaction site [polypeptide binding]; other site
1282356010849	GTP/Mg2+ binding site [chemical binding]; other site
1282356010850	Switch I region; other site
1282356010851	G2 box; other site
1282356010852	G3 box; other site
1282356010853	Switch II region; other site
1282356010854	G4 box; other site
1282356010855	G5 box; other site
1282356010856	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1282356010857	Translation-initiation factor 2; Region: IF-2; pfam11987
1282356010858	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1282356010859	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
1282356010860	NusA N-terminal domain; Region: NusA_N; pfam08529
1282356010861	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1282356010862	RNA binding site [nucleotide binding]; other site
1282356010863	homodimer interface [polypeptide binding]; other site
1282356010864	NusA-like KH domain; Region: KH_5; pfam13184
1282356010865	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1282356010866	G-X-X-G motif; other site
1282356010867	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
1282356010868	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
1282356010869	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1282356010870	Sm and related proteins; Region: Sm_like; cl00259
1282356010871	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1282356010872	putative oligomer interface [polypeptide binding]; other site
1282356010873	putative RNA binding site [nucleotide binding]; other site
1282356010874	Preprotein translocase SecG subunit; Region: SecG; pfam03840
1282356010875	triosephosphate isomerase; Provisional; Region: PRK14567
1282356010876	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1282356010877	substrate binding site [chemical binding]; other site
1282356010878	dimer interface [polypeptide binding]; other site
1282356010879	catalytic triad [active]
1282356010880	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
1282356010881	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1282356010882	active site
1282356010883	substrate binding site [chemical binding]; other site
1282356010884	metal binding site [ion binding]; metal-binding site
1282356010885	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1282356010886	dihydropteroate synthase; Region: DHPS; TIGR01496
1282356010887	substrate binding pocket [chemical binding]; other site
1282356010888	dimer interface [polypeptide binding]; other site
1282356010889	inhibitor binding site; inhibition site
1282356010890	FtsH Extracellular; Region: FtsH_ext; pfam06480
1282356010891	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1282356010892	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356010893	Walker A motif; other site
1282356010894	ATP binding site [chemical binding]; other site
1282356010895	Walker B motif; other site
1282356010896	arginine finger; other site
1282356010897	Peptidase family M41; Region: Peptidase_M41; pfam01434
1282356010898	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
1282356010899	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356010900	S-adenosylmethionine binding site [chemical binding]; other site
1282356010901	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103
1282356010902	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1282356010903	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1282356010904	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1282356010905	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1282356010906	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1282356010907	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1282356010908	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1282356010909	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1282356010910	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1282356010911	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1282356010912	IMP binding site; other site
1282356010913	dimer interface [polypeptide binding]; other site
1282356010914	interdomain contacts; other site
1282356010915	partial ornithine binding site; other site
1282356010916	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1282356010917	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1282356010918	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1282356010919	catalytic site [active]
1282356010920	subunit interface [polypeptide binding]; other site
1282356010921	dihydrodipicolinate reductase; Provisional; Region: PRK00048
1282356010922	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1282356010923	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1282356010924	chaperone protein DnaJ; Provisional; Region: PRK10767
1282356010925	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1282356010926	HSP70 interaction site [polypeptide binding]; other site
1282356010927	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
1282356010928	substrate binding site [polypeptide binding]; other site
1282356010929	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1282356010930	Zn binding sites [ion binding]; other site
1282356010931	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1282356010932	dimer interface [polypeptide binding]; other site
1282356010933	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1282356010934	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1282356010935	nucleotide binding site [chemical binding]; other site
1282356010936	GrpE; Region: GrpE; pfam01025
1282356010937	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1282356010938	dimer interface [polypeptide binding]; other site
1282356010939	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1282356010940	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1282356010941	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1282356010942	Walker A/P-loop; other site
1282356010943	ATP binding site [chemical binding]; other site
1282356010944	Q-loop/lid; other site
1282356010945	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1282356010946	Q-loop/lid; other site
1282356010947	ABC transporter signature motif; other site
1282356010948	Walker B; other site
1282356010949	D-loop; other site
1282356010950	H-loop/switch region; other site
1282356010951	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1282356010952	metal binding site 2 [ion binding]; metal-binding site
1282356010953	putative DNA binding helix; other site
1282356010954	metal binding site 1 [ion binding]; metal-binding site
1282356010955	dimer interface [polypeptide binding]; other site
1282356010956	structural Zn2+ binding site [ion binding]; other site
1282356010957	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
1282356010958	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
1282356010959	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
1282356010960	RnfH family Ubiquitin; Region: Ub-RnfH; cl17382
1282356010961	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
1282356010962	putative coenzyme Q binding site [chemical binding]; other site
1282356010963	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1282356010964	SmpB-tmRNA interface; other site
1282356010965	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1282356010966	FAD binding domain; Region: FAD_binding_4; pfam01565
1282356010967	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1282356010968	integrase; Provisional; Region: PRK09692
1282356010969	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
1282356010970	active site
1282356010971	Int/Topo IB signature motif; other site
1282356010972	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1282356010973	active site
1282356010974	ATP binding site [chemical binding]; other site
1282356010975	substrate binding site [chemical binding]; other site
1282356010976	activation loop (A-loop); other site
1282356010977	von Willebrand factor (vWF) type A domain; Region: VWA; smart00327
1282356010978	metal ion-dependent adhesion site (MIDAS); other site
1282356010979	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1282356010980	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1282356010981	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
1282356010982	A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411
1282356010983	Domain of unknown function DUF87; Region: DUF87; pfam01935
1282356010984	AAA-like domain; Region: AAA_10; pfam12846
1282356010985	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
1282356010986	Dynamin family; Region: Dynamin_N; pfam00350
1282356010987	G1 box; other site
1282356010988	GTP/Mg2+ binding site [chemical binding]; other site
1282356010989	G2 box; other site
1282356010990	Switch I region; other site
1282356010991	G3 box; other site
1282356010992	Switch II region; other site
1282356010993	G4 box; other site
1282356010994	G5 box; other site
1282356010995	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1282356010996	GTP/Mg2+ binding site [chemical binding]; other site
1282356010997	G1 box; other site
1282356010998	G2 box; other site
1282356010999	Switch I region; other site
1282356011000	G3 box; other site
1282356011001	Switch II region; other site
1282356011002	G4 box; other site
1282356011003	G5 box; other site
1282356011004	WYL domain; Region: WYL; pfam13280
1282356011005	Domain of unknown function (DUF932); Region: DUF932; cl12129
1282356011006	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1282356011007	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1282356011008	DNA-binding site [nucleotide binding]; DNA binding site
1282356011009	FCD domain; Region: FCD; pfam07729
1282356011010	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
1282356011011	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
1282356011012	putative active site [active]
1282356011013	hypothetical protein; Provisional; Region: PRK05463
1282356011014	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
1282356011015	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
1282356011016	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
1282356011017	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
1282356011018	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1282356011019	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1282356011020	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1282356011021	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1282356011022	carboxyltransferase (CT) interaction site; other site
1282356011023	biotinylation site [posttranslational modification]; other site
1282356011024	LabA_like proteins; Region: LabA_like; cd06167
1282356011025	putative metal binding site [ion binding]; other site
1282356011026	Uncharacterized conserved protein [Function unknown]; Region: COG1432
1282356011027	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1282356011028	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
1282356011029	hypothetical protein; Provisional; Region: PRK05208
1282356011030	AAA domain; Region: AAA_32; pfam13654
1282356011031	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1282356011032	Protein of unknown function (DUF3015); Region: DUF3015; pfam11220
1282356011033	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
1282356011034	transcription elongation factor regulatory protein; Validated; Region: PRK06342
1282356011035	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1282356011036	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
1282356011037	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1282356011038	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1282356011039	ABC transporter; Region: ABC_tran_2; pfam12848
1282356011040	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1282356011041	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1282356011042	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356011043	putative active site [active]
1282356011044	heme pocket [chemical binding]; other site
1282356011045	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
1282356011046	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356011047	PAS domain; Region: PAS_9; pfam13426
1282356011048	putative active site [active]
1282356011049	heme pocket [chemical binding]; other site
1282356011050	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1282356011051	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1282356011052	metal binding site [ion binding]; metal-binding site
1282356011053	active site
1282356011054	I-site; other site
1282356011055	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1282356011056	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1282356011057	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1282356011058	dimer interface [polypeptide binding]; other site
1282356011059	active site
1282356011060	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1282356011061	folate binding site [chemical binding]; other site
1282356011062	putative GTP-binding protein YjiA; Provisional; Region: PRK11537
1282356011063	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
1282356011064	P-loop, Walker A motif; other site
1282356011065	Base recognition motif; other site
1282356011066	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1282356011067	Protein of unknown function (DUF466); Region: DUF466; pfam04328
1282356011068	carbon starvation protein A; Provisional; Region: PRK15015
1282356011069	Carbon starvation protein CstA; Region: CstA; pfam02554
1282356011070	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
1282356011071	PilZ domain; Region: PilZ; pfam07238
1282356011072	DNA repair protein RadA; Provisional; Region: PRK11823
1282356011073	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
1282356011074	Walker A motif/ATP binding site; other site
1282356011075	ATP binding site [chemical binding]; other site
1282356011076	Walker B motif; other site
1282356011077	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1282356011078	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1282356011079	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1282356011080	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1282356011081	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1282356011082	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
1282356011083	tetramer interface [polypeptide binding]; other site
1282356011084	heme binding pocket [chemical binding]; other site
1282356011085	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
1282356011086	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1282356011087	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
1282356011088	ferredoxin-NADP reductase; Provisional; Region: PRK10926
1282356011089	FAD binding pocket [chemical binding]; other site
1282356011090	FAD binding motif [chemical binding]; other site
1282356011091	phosphate binding motif [ion binding]; other site
1282356011092	beta-alpha-beta structure motif; other site
1282356011093	NAD binding pocket [chemical binding]; other site
1282356011094	Autoinducer binding domain; Region: Autoind_bind; pfam03472
1282356011095	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1282356011096	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1282356011097	DNA binding residues [nucleotide binding]
1282356011098	dimerization interface [polypeptide binding]; other site
1282356011099	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
1282356011100	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356011101	S-adenosylmethionine binding site [chemical binding]; other site
1282356011102	Protein of unknown function (DUF2474); Region: DUF2474; pfam10617
1282356011103	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1282356011104	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1282356011105	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1282356011106	enterobactin exporter EntS; Provisional; Region: PRK10489
1282356011107	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356011108	putative substrate translocation pore; other site
1282356011109	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
1282356011110	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1282356011111	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1282356011112	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
1282356011113	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
1282356011114	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
1282356011115	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1282356011116	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1282356011117	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
1282356011118	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356011119	S-adenosylmethionine binding site [chemical binding]; other site
1282356011120	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
1282356011121	Dehydroquinase class II; Region: DHquinase_II; pfam01220
1282356011122	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1282356011123	active site
1282356011124	trimer interface [polypeptide binding]; other site
1282356011125	dimer interface [polypeptide binding]; other site
1282356011126	shikimate 5-dehydrogenase; Reviewed; Region: PRK12549
1282356011127	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1282356011128	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1282356011129	shikimate binding site; other site
1282356011130	NAD(P) binding site [chemical binding]; other site
1282356011131	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1282356011132	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1282356011133	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1282356011134	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
1282356011135	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
1282356011136	dimer interface [polypeptide binding]; other site
1282356011137	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
1282356011138	active site
1282356011139	Fe binding site [ion binding]; other site
1282356011140	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356011141	D-galactonate transporter; Region: 2A0114; TIGR00893
1282356011142	putative substrate translocation pore; other site
1282356011143	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1282356011144	EamA-like transporter family; Region: EamA; pfam00892
1282356011145	Lysosome-associated membrane glycoprotein (Lamp); Region: Lamp; pfam01299
1282356011146	Predicted metalloprotease [General function prediction only]; Region: COG2321
1282356011147	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
1282356011148	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1282356011149	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1282356011150	active site
1282356011151	motif I; other site
1282356011152	motif II; other site
1282356011153	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
1282356011154	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
1282356011155	active site
1282356011156	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
1282356011157	catalytic triad [active]
1282356011158	dimer interface [polypeptide binding]; other site
1282356011159	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1282356011160	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1282356011161	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
1282356011162	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
1282356011163	putative active site [active]
1282356011164	Zn binding site [ion binding]; other site
1282356011165	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
1282356011166	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
1282356011167	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1282356011168	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1282356011169	ATP binding site [chemical binding]; other site
1282356011170	Mg++ binding site [ion binding]; other site
1282356011171	motif III; other site
1282356011172	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1282356011173	nucleotide binding region [chemical binding]; other site
1282356011174	ATP-binding site [chemical binding]; other site
1282356011175	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
1282356011176	EamA-like transporter family; Region: EamA; pfam00892
1282356011177	EamA-like transporter family; Region: EamA; pfam00892
1282356011178	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1282356011179	active site
1282356011180	catalytic site [active]
1282356011181	substrate binding site [chemical binding]; other site
1282356011182	Uncharacterized conserved protein [Function unknown]; Region: COG1432
1282356011183	LabA_like proteins; Region: LabA; cd10911
1282356011184	putative metal binding site [ion binding]; other site
1282356011185	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
1282356011186	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974
1282356011187	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1282356011188	putative catalytic site [active]
1282356011189	putative metal binding site [ion binding]; other site
1282356011190	putative phosphate binding site [ion binding]; other site
1282356011191	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
1282356011192	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1282356011193	ATP binding site [chemical binding]; other site
1282356011194	putative Mg++ binding site [ion binding]; other site
1282356011195	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1282356011196	nucleotide binding region [chemical binding]; other site
1282356011197	ATP-binding site [chemical binding]; other site
1282356011198	Helicase associated domain (HA2); Region: HA2; pfam04408
1282356011199	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
1282356011200	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1282356011201	Cation efflux family; Region: Cation_efflux; cl00316
1282356011202	Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436
1282356011203	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1282356011204	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1282356011205	putative DNA binding site [nucleotide binding]; other site
1282356011206	putative Zn2+ binding site [ion binding]; other site
1282356011207	AsnC family; Region: AsnC_trans_reg; pfam01037
1282356011208	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
1282356011209	pseudouridine synthase; Region: TIGR00093
1282356011210	active site
1282356011211	AMP nucleosidase; Provisional; Region: PRK08292
1282356011212	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
1282356011213	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
1282356011214	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
1282356011215	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1282356011216	active site
1282356011217	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
1282356011218	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
1282356011219	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1282356011220	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356011221	dimer interface [polypeptide binding]; other site
1282356011222	phosphorylation site [posttranslational modification]
1282356011223	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356011224	ATP binding site [chemical binding]; other site
1282356011225	Mg2+ binding site [ion binding]; other site
1282356011226	G-X-G motif; other site
1282356011227	Response regulator receiver domain; Region: Response_reg; pfam00072
1282356011228	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356011229	active site
1282356011230	phosphorylation site [posttranslational modification]
1282356011231	intermolecular recognition site; other site
1282356011232	dimerization interface [polypeptide binding]; other site
1282356011233	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1282356011234	dimer interface [polypeptide binding]; other site
1282356011235	substrate binding site [chemical binding]; other site
1282356011236	ATP binding site [chemical binding]; other site
1282356011237	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1282356011238	thiamine phosphate binding site [chemical binding]; other site
1282356011239	active site
1282356011240	pyrophosphate binding site [ion binding]; other site
1282356011241	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
1282356011242	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1282356011243	inhibitor-cofactor binding pocket; inhibition site
1282356011244	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356011245	catalytic residue [active]
1282356011246	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1282356011247	Sel1-like repeats; Region: SEL1; smart00671
1282356011248	Sel1-like repeats; Region: SEL1; smart00671
1282356011249	Domain of unknown function (DUF1820); Region: DUF1820; pfam08850
1282356011250	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
1282356011251	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1282356011252	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1282356011253	FeS/SAM binding site; other site
1282356011254	TRAM domain; Region: TRAM; pfam01938
1282356011255	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1282356011256	PhoH-like protein; Region: PhoH; pfam02562
1282356011257	metal-binding heat shock protein; Provisional; Region: PRK00016
1282356011258	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
1282356011259	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1282356011260	Transporter associated domain; Region: CorC_HlyC; smart01091
1282356011261	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
1282356011262	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
1282356011263	putative active site [active]
1282356011264	catalytic triad [active]
1282356011265	putative dimer interface [polypeptide binding]; other site
1282356011266	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1282356011267	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1282356011268	putative active site [active]
1282356011269	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1282356011270	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1282356011271	HIGH motif; other site
1282356011272	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1282356011273	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1282356011274	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1282356011275	active site
1282356011276	KMSKS motif; other site
1282356011277	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1282356011278	tRNA binding surface [nucleotide binding]; other site
1282356011279	Lipopolysaccharide-assembly; Region: LptE; cl01125
1282356011280	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
1282356011281	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1282356011282	Domain of unknown function; Region: DUF331; cl01149
1282356011283	Transglycosylase SLT domain; Region: SLT_2; pfam13406
1282356011284	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1282356011285	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1282356011286	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1282356011287	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
1282356011288	dimer interface [polypeptide binding]; other site
1282356011289	catalytic triad [active]
1282356011290	lipoyl synthase; Provisional; Region: PRK05481
1282356011291	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1282356011292	FeS/SAM binding site; other site
1282356011293	lipoate-protein ligase B; Provisional; Region: PRK14342
1282356011294	hypothetical protein; Provisional; Region: PRK00341
1282356011295	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1282356011296	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1282356011297	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
1282356011298	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
1282356011299	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
1282356011300	Sporulation related domain; Region: SPOR; pfam05036
1282356011301	Transglycosylase SLT domain; Region: SLT_2; pfam13406
1282356011302	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1282356011303	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1282356011304	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
1282356011305	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
1282356011306	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1282356011307	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1282356011308	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
1282356011309	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
1282356011310	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
1282356011311	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1282356011312	active site
1282356011313	(T/H)XGH motif; other site
1282356011314	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1282356011315	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1282356011316	putative catalytic cysteine [active]
1282356011317	3-methyladenine DNA glycosylase; Reviewed; Region: PRK00802
1282356011318	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1282356011319	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1282356011320	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1282356011321	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1282356011322	active site
1282356011323	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
1282356011324	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
1282356011325	LrgA family; Region: LrgA; cl00608
1282356011326	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
1282356011327	putative active site [active]
1282356011328	putative catalytic site [active]
1282356011329	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
1282356011330	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
1282356011331	Peptidase C13 family; Region: Peptidase_C13; cl02159
1282356011332	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1282356011333	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
1282356011334	NAD binding site [chemical binding]; other site
1282356011335	active site
1282356011336	Protein of unknown function (DUF1375); Region: DUF1375; cl11456
1282356011337	aromatic acid decarboxylase; Validated; Region: PRK05920
1282356011338	Flavoprotein; Region: Flavoprotein; pfam02441
1282356011339	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
1282356011340	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1282356011341	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1282356011342	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1282356011343	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
1282356011344	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356011345	Walker A motif; other site
1282356011346	ATP binding site [chemical binding]; other site
1282356011347	Walker B motif; other site
1282356011348	arginine finger; other site
1282356011349	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1282356011350	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1282356011351	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1282356011352	NAD(P) binding site [chemical binding]; other site
1282356011353	catalytic residues [active]
1282356011354	ethanolamine permease; Region: 2A0305; TIGR00908
1282356011355	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
1282356011356	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
1282356011357	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
1282356011358	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1282356011359	Coenzyme A binding pocket [chemical binding]; other site
1282356011360	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1282356011361	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1282356011362	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167
1282356011363	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
1282356011364	dimer interface [polypeptide binding]; other site
1282356011365	substrate binding site [chemical binding]; other site
1282356011366	metal binding sites [ion binding]; metal-binding site
1282356011367	Predicted transcriptional regulator [Transcription]; Region: COG2932
1282356011368	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1282356011369	Catalytic site [active]
1282356011370	Isochorismatase family; Region: Isochorismatase; pfam00857
1282356011371	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
1282356011372	catalytic triad [active]
1282356011373	dimer interface [polypeptide binding]; other site
1282356011374	conserved cis-peptide bond; other site
1282356011375	GAF domain; Region: GAF; pfam01590
1282356011376	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1282356011377	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356011378	dimer interface [polypeptide binding]; other site
1282356011379	phosphorylation site [posttranslational modification]
1282356011380	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356011381	ATP binding site [chemical binding]; other site
1282356011382	Mg2+ binding site [ion binding]; other site
1282356011383	G-X-G motif; other site
1282356011384	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
1282356011385	RHS Repeat; Region: RHS_repeat; pfam05593
1282356011386	RHS Repeat; Region: RHS_repeat; cl11982
1282356011387	RHS Repeat; Region: RHS_repeat; pfam05593
1282356011388	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
1282356011389	RHS Repeat; Region: RHS_repeat; cl11982
1282356011390	RHS Repeat; Region: RHS_repeat; pfam05593
1282356011391	RHS Repeat; Region: RHS_repeat; pfam05593
1282356011392	RHS protein; Region: RHS; pfam03527
1282356011393	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
1282356011394	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
1282356011395	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
1282356011396	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1282356011397	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1282356011398	substrate binding pocket [chemical binding]; other site
1282356011399	chain length determination region; other site
1282356011400	substrate-Mg2+ binding site; other site
1282356011401	catalytic residues [active]
1282356011402	aspartate-rich region 1; other site
1282356011403	active site lid residues [active]
1282356011404	aspartate-rich region 2; other site
1282356011405	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
1282356011406	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
1282356011407	TPP-binding site; other site
1282356011408	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1282356011409	PYR/PP interface [polypeptide binding]; other site
1282356011410	dimer interface [polypeptide binding]; other site
1282356011411	TPP binding site [chemical binding]; other site
1282356011412	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1282356011413	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
1282356011414	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1282356011415	N-terminal plug; other site
1282356011416	ligand-binding site [chemical binding]; other site
1282356011417	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
1282356011418	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
1282356011419	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1282356011420	cobalamin binding residues [chemical binding]; other site
1282356011421	putative BtuC binding residues; other site
1282356011422	dimer interface [polypeptide binding]; other site
1282356011423	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1282356011424	dimerization interface [polypeptide binding]; other site
1282356011425	active site
1282356011426	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1282356011427	membrane-bound complex binding site; other site
1282356011428	hinge residues; other site
1282356011429	thiamine monophosphate kinase; Provisional; Region: PRK05731
1282356011430	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
1282356011431	ATP binding site [chemical binding]; other site
1282356011432	dimerization interface [polypeptide binding]; other site
1282356011433	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
1282356011434	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1282356011435	homopentamer interface [polypeptide binding]; other site
1282356011436	active site
1282356011437	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
1282356011438	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1282356011439	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
1282356011440	dimerization interface [polypeptide binding]; other site
1282356011441	active site
1282356011442	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
1282356011443	Lumazine binding domain; Region: Lum_binding; pfam00677
1282356011444	Lumazine binding domain; Region: Lum_binding; pfam00677
1282356011445	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
1282356011446	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1282356011447	catalytic motif [active]
1282356011448	Zn binding site [ion binding]; other site
1282356011449	RibD C-terminal domain; Region: RibD_C; cl17279
1282356011450	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1282356011451	ATP cone domain; Region: ATP-cone; pfam03477
1282356011452	Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825
1282356011453	Predicted methyltransferase [General function prediction only]; Region: COG3897
1282356011454	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
1282356011455	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
1282356011456	Protein of unknown function (DUF2796); Region: DUF2796; pfam10986
1282356011457	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1282356011458	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1282356011459	Walker A/P-loop; other site
1282356011460	ATP binding site [chemical binding]; other site
1282356011461	Q-loop/lid; other site
1282356011462	ABC transporter signature motif; other site
1282356011463	Walker B; other site
1282356011464	D-loop; other site
1282356011465	H-loop/switch region; other site
1282356011466	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1282356011467	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1282356011468	FtsX-like permease family; Region: FtsX; pfam02687
1282356011469	Protein of unknown function (DUF3299); Region: DUF3299; pfam11736
1282356011470	OmpW family; Region: OmpW; cl17427
1282356011471	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
1282356011472	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1282356011473	NAD(P) binding site [chemical binding]; other site
1282356011474	active site
1282356011475	Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201
1282356011476	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1282356011477	ATP binding site [chemical binding]; other site
1282356011478	putative Mg++ binding site [ion binding]; other site
1282356011479	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1282356011480	nucleotide binding region [chemical binding]; other site
1282356011481	ATP-binding site [chemical binding]; other site
1282356011482	DEAD/H associated; Region: DEAD_assoc; pfam08494
1282356011483	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1282356011484	putative DNA binding site [nucleotide binding]; other site
1282356011485	putative Zn2+ binding site [ion binding]; other site
1282356011486	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1282356011487	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1282356011488	Protein of unknown function DUF72; Region: DUF72; pfam01904
1282356011489	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
1282356011490	putative catalytic site [active]
1282356011491	putative metal binding site [ion binding]; other site
1282356011492	putative phosphate binding site [ion binding]; other site
1282356011493	cardiolipin synthase 2; Provisional; Region: PRK11263
1282356011494	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1282356011495	putative active site [active]
1282356011496	catalytic site [active]
1282356011497	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
1282356011498	putative active site [active]
1282356011499	catalytic site [active]
1282356011500	Predicted integral membrane protein [Function unknown]; Region: COG0392
1282356011501	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1282356011502	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1282356011503	Protein of unknown function (DUF3182); Region: DUF3182; pfam11379
1282356011504	Isochorismatase family; Region: Isochorismatase; pfam00857
1282356011505	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
1282356011506	catalytic triad [active]
1282356011507	conserved cis-peptide bond; other site
1282356011508	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
1282356011509	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356011510	S-adenosylmethionine binding site [chemical binding]; other site
1282356011511	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1282356011512	dimerization interface [polypeptide binding]; other site
1282356011513	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1282356011514	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356011515	dimer interface [polypeptide binding]; other site
1282356011516	putative CheW interface [polypeptide binding]; other site
1282356011517	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1282356011518	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1282356011519	dimer interface [polypeptide binding]; other site
1282356011520	ssDNA binding site [nucleotide binding]; other site
1282356011521	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1282356011522	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356011523	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1282356011524	putative substrate translocation pore; other site
1282356011525	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1282356011526	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1282356011527	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1282356011528	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1282356011529	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
1282356011530	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
1282356011531	heme binding site [chemical binding]; other site
1282356011532	ferroxidase pore; other site
1282356011533	ferroxidase diiron center [ion binding]; other site
1282356011534	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1282356011535	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
1282356011536	tetramer interface [polypeptide binding]; other site
1282356011537	heme binding pocket [chemical binding]; other site
1282356011538	NADPH binding site [chemical binding]; other site
1282356011539	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1282356011540	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1282356011541	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1282356011542	alphaNTD homodimer interface [polypeptide binding]; other site
1282356011543	alphaNTD - beta interaction site [polypeptide binding]; other site
1282356011544	alphaNTD - beta' interaction site [polypeptide binding]; other site
1282356011545	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1282356011546	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1282356011547	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1282356011548	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1282356011549	RNA binding surface [nucleotide binding]; other site
1282356011550	30S ribosomal protein S11; Validated; Region: PRK05309
1282356011551	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
1282356011552	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1282356011553	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1282356011554	SecY translocase; Region: SecY; pfam00344
1282356011555	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1282356011556	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1282356011557	23S rRNA binding site [nucleotide binding]; other site
1282356011558	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1282356011559	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1282356011560	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1282356011561	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1282356011562	5S rRNA interface [nucleotide binding]; other site
1282356011563	23S rRNA interface [nucleotide binding]; other site
1282356011564	L5 interface [polypeptide binding]; other site
1282356011565	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1282356011566	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1282356011567	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1282356011568	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1282356011569	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1282356011570	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1282356011571	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1282356011572	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1282356011573	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1282356011574	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1282356011575	RNA binding site [nucleotide binding]; other site
1282356011576	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1282356011577	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1282356011578	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1282356011579	23S rRNA interface [nucleotide binding]; other site
1282356011580	putative translocon interaction site; other site
1282356011581	signal recognition particle (SRP54) interaction site; other site
1282356011582	L23 interface [polypeptide binding]; other site
1282356011583	trigger factor interaction site; other site
1282356011584	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1282356011585	23S rRNA interface [nucleotide binding]; other site
1282356011586	5S rRNA interface [nucleotide binding]; other site
1282356011587	putative antibiotic binding site [chemical binding]; other site
1282356011588	L25 interface [polypeptide binding]; other site
1282356011589	L27 interface [polypeptide binding]; other site
1282356011590	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1282356011591	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1282356011592	G-X-X-G motif; other site
1282356011593	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1282356011594	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1282356011595	protein-rRNA interface [nucleotide binding]; other site
1282356011596	putative translocon binding site; other site
1282356011597	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1282356011598	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1282356011599	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1282356011600	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1282356011601	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1282356011602	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1282356011603	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1282356011604	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1282356011605	elongation factor Tu; Reviewed; Region: PRK00049
1282356011606	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1282356011607	G1 box; other site
1282356011608	GEF interaction site [polypeptide binding]; other site
1282356011609	GTP/Mg2+ binding site [chemical binding]; other site
1282356011610	Switch I region; other site
1282356011611	G2 box; other site
1282356011612	G3 box; other site
1282356011613	Switch II region; other site
1282356011614	G4 box; other site
1282356011615	G5 box; other site
1282356011616	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1282356011617	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1282356011618	Antibiotic Binding Site [chemical binding]; other site
1282356011619	elongation factor G; Reviewed; Region: PRK00007
1282356011620	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1282356011621	G1 box; other site
1282356011622	putative GEF interaction site [polypeptide binding]; other site
1282356011623	GTP/Mg2+ binding site [chemical binding]; other site
1282356011624	Switch I region; other site
1282356011625	G2 box; other site
1282356011626	G3 box; other site
1282356011627	Switch II region; other site
1282356011628	G4 box; other site
1282356011629	G5 box; other site
1282356011630	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1282356011631	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1282356011632	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1282356011633	30S ribosomal protein S7; Validated; Region: PRK05302
1282356011634	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1282356011635	S17 interaction site [polypeptide binding]; other site
1282356011636	S8 interaction site; other site
1282356011637	16S rRNA interaction site [nucleotide binding]; other site
1282356011638	streptomycin interaction site [chemical binding]; other site
1282356011639	23S rRNA interaction site [nucleotide binding]; other site
1282356011640	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1282356011641	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
1282356011642	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1282356011643	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1282356011644	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1282356011645	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1282356011646	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
1282356011647	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1282356011648	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
1282356011649	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1282356011650	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1282356011651	DNA binding site [nucleotide binding]
1282356011652	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1282356011653	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1282356011654	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1282356011655	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1282356011656	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1282356011657	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
1282356011658	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1282356011659	RPB3 interaction site [polypeptide binding]; other site
1282356011660	RPB1 interaction site [polypeptide binding]; other site
1282356011661	RPB11 interaction site [polypeptide binding]; other site
1282356011662	RPB10 interaction site [polypeptide binding]; other site
1282356011663	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1282356011664	peripheral dimer interface [polypeptide binding]; other site
1282356011665	core dimer interface [polypeptide binding]; other site
1282356011666	L10 interface [polypeptide binding]; other site
1282356011667	L11 interface [polypeptide binding]; other site
1282356011668	putative EF-Tu interaction site [polypeptide binding]; other site
1282356011669	putative EF-G interaction site [polypeptide binding]; other site
1282356011670	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1282356011671	23S rRNA interface [nucleotide binding]; other site
1282356011672	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1282356011673	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1282356011674	mRNA/rRNA interface [nucleotide binding]; other site
1282356011675	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1282356011676	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1282356011677	23S rRNA interface [nucleotide binding]; other site
1282356011678	L7/L12 interface [polypeptide binding]; other site
1282356011679	putative thiostrepton binding site; other site
1282356011680	L25 interface [polypeptide binding]; other site
1282356011681	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1282356011682	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1282356011683	putative homodimer interface [polypeptide binding]; other site
1282356011684	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1282356011685	heterodimer interface [polypeptide binding]; other site
1282356011686	homodimer interface [polypeptide binding]; other site
1282356011687	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
1282356011688	pantothenate kinase; Reviewed; Region: PRK13322
1282356011689	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
1282356011690	Biotin operon repressor [Transcription]; Region: BirA; COG1654
1282356011691	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
1282356011692	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
1282356011693	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1282356011694	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1282356011695	active site
1282356011696	HIGH motif; other site
1282356011697	dimer interface [polypeptide binding]; other site
1282356011698	KMSKS motif; other site
1282356011699	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
1282356011700	Peptidase family M23; Region: Peptidase_M23; pfam01551
1282356011701	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
1282356011702	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
1282356011703	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
1282356011704	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1282356011705	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
1282356011706	Protein of unknown function (DUF805); Region: DUF805; pfam05656
1282356011707	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1282356011708	classical (c) SDRs; Region: SDR_c; cd05233
1282356011709	NAD(P) binding site [chemical binding]; other site
1282356011710	active site
1282356011711	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
1282356011712	nucleotide binding site/active site [active]
1282356011713	HIT family signature motif; other site
1282356011714	catalytic residue [active]
1282356011715	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
1282356011716	diiron binding motif [ion binding]; other site
1282356011717	OsmC-like protein; Region: OsmC; cl00767
1282356011718	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
1282356011719	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1282356011720	ligand binding site [chemical binding]; other site
1282356011721	flexible hinge region; other site
1282356011722	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1282356011723	putative switch regulator; other site
1282356011724	non-specific DNA interactions [nucleotide binding]; other site
1282356011725	DNA binding site [nucleotide binding]
1282356011726	sequence specific DNA binding site [nucleotide binding]; other site
1282356011727	putative cAMP binding site [chemical binding]; other site
1282356011728	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1282356011729	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1282356011730	active site
1282356011731	ribulose/triose binding site [chemical binding]; other site
1282356011732	phosphate binding site [ion binding]; other site
1282356011733	substrate (anthranilate) binding pocket [chemical binding]; other site
1282356011734	product (indole) binding pocket [chemical binding]; other site
1282356011735	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1282356011736	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1282356011737	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1282356011738	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
1282356011739	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1282356011740	glutamine binding [chemical binding]; other site
1282356011741	catalytic triad [active]
1282356011742	phosphoglycolate phosphatase; Provisional; Region: PRK13223
1282356011743	Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240
1282356011744	Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847
1282356011745	active site
1282356011746	catalytic triad [active]
1282356011747	oxyanion hole [active]
1282356011748	Autotransporter beta-domain; Region: Autotransporter; pfam03797
1282356011749	anthranilate synthase component I; Provisional; Region: PRK13565
1282356011750	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1282356011751	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1282356011752	phosphoglycolate phosphatase; Provisional; Region: PRK13223
1282356011753	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1282356011754	motif II; other site
1282356011755	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1282356011756	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
1282356011757	substrate binding site [chemical binding]; other site
1282356011758	hexamer interface [polypeptide binding]; other site
1282356011759	metal binding site [ion binding]; metal-binding site
1282356011760	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1282356011761	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
1282356011762	active site
1282356011763	NAD binding site [chemical binding]; other site
1282356011764	metal binding site [ion binding]; metal-binding site
1282356011765	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1282356011766	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356011767	dimer interface [polypeptide binding]; other site
1282356011768	conserved gate region; other site
1282356011769	putative PBP binding loops; other site
1282356011770	ABC-ATPase subunit interface; other site
1282356011771	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356011772	dimer interface [polypeptide binding]; other site
1282356011773	conserved gate region; other site
1282356011774	putative PBP binding loops; other site
1282356011775	ABC-ATPase subunit interface; other site
1282356011776	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1282356011777	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1282356011778	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1282356011779	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
1282356011780	Walker A/P-loop; other site
1282356011781	ATP binding site [chemical binding]; other site
1282356011782	Q-loop/lid; other site
1282356011783	ABC transporter signature motif; other site
1282356011784	Walker B; other site
1282356011785	D-loop; other site
1282356011786	H-loop/switch region; other site
1282356011787	TOBE domain; Region: TOBE_2; pfam08402
1282356011788	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1282356011789	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356011790	active site
1282356011791	phosphorylation site [posttranslational modification]
1282356011792	intermolecular recognition site; other site
1282356011793	dimerization interface [polypeptide binding]; other site
1282356011794	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1282356011795	DNA binding residues [nucleotide binding]
1282356011796	dimerization interface [polypeptide binding]; other site
1282356011797	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1282356011798	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1282356011799	substrate binding pocket [chemical binding]; other site
1282356011800	membrane-bound complex binding site; other site
1282356011801	hinge residues; other site
1282356011802	PAS domain; Region: PAS_9; pfam13426
1282356011803	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356011804	putative active site [active]
1282356011805	heme pocket [chemical binding]; other site
1282356011806	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1282356011807	Histidine kinase; Region: HisKA_3; pfam07730
1282356011808	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356011809	ATP binding site [chemical binding]; other site
1282356011810	Mg2+ binding site [ion binding]; other site
1282356011811	G-X-G motif; other site
1282356011812	Protein of unknown function (DUF3530); Region: DUF3530; pfam12048
1282356011813	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1282356011814	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
1282356011815	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
1282356011816	putative metal binding site [ion binding]; other site
1282356011817	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1282356011818	HSP70 interaction site [polypeptide binding]; other site
1282356011819	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1282356011820	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
1282356011821	Substrate binding site; other site
1282356011822	metal-binding site
1282356011823	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
1282356011824	Phosphotransferase enzyme family; Region: APH; pfam01636
1282356011825	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
1282356011826	OstA-like protein; Region: OstA; cl00844
1282356011827	Organic solvent tolerance protein; Region: OstA_C; pfam04453
1282356011828	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
1282356011829	SurA N-terminal domain; Region: SurA_N; pfam09312
1282356011830	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1282356011831	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1282356011832	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
1282356011833	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
1282356011834	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1282356011835	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
1282356011836	S-adenosylmethionine binding site [chemical binding]; other site
1282356011837	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
1282356011838	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
1282356011839	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
1282356011840	active site
1282356011841	metal binding site [ion binding]; metal-binding site
1282356011842	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
1282356011843	active site residue [active]
1282356011844	PrkA family serine protein kinase; Provisional; Region: PRK15455
1282356011845	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
1282356011846	hypothetical protein; Provisional; Region: PRK05325
1282356011847	SpoVR family protein; Provisional; Region: PRK11767
1282356011848	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
1282356011849	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
1282356011850	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1282356011851	active site
1282356011852	NTP binding site [chemical binding]; other site
1282356011853	metal binding triad [ion binding]; metal-binding site
1282356011854	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1282356011855	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1282356011856	Zn2+ binding site [ion binding]; other site
1282356011857	Mg2+ binding site [ion binding]; other site
1282356011858	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1282356011859	catalytic center binding site [active]
1282356011860	ATP binding site [chemical binding]; other site
1282356011861	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1282356011862	homooctamer interface [polypeptide binding]; other site
1282356011863	active site
1282356011864	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
1282356011865	UGMP family protein; Validated; Region: PRK09604
1282356011866	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1282356011867	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1282356011868	DNA primase, catalytic core; Region: dnaG; TIGR01391
1282356011869	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1282356011870	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1282356011871	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1282356011872	active site
1282356011873	metal binding site [ion binding]; metal-binding site
1282356011874	interdomain interaction site; other site
1282356011875	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
1282356011876	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
1282356011877	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
1282356011878	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
1282356011879	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1282356011880	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
1282356011881	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1282356011882	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1282356011883	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1282356011884	DNA binding residues [nucleotide binding]
1282356011885	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1282356011886	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1282356011887	substrate binding pocket [chemical binding]; other site
1282356011888	membrane-bound complex binding site; other site
1282356011889	hinge residues; other site
1282356011890	PAS domain S-box; Region: sensory_box; TIGR00229
1282356011891	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356011892	putative active site [active]
1282356011893	heme pocket [chemical binding]; other site
1282356011894	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356011895	PAS domain; Region: PAS_9; pfam13426
1282356011896	putative active site [active]
1282356011897	heme pocket [chemical binding]; other site
1282356011898	PAS domain S-box; Region: sensory_box; TIGR00229
1282356011899	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356011900	putative active site [active]
1282356011901	heme pocket [chemical binding]; other site
1282356011902	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356011903	PAS domain; Region: PAS_9; pfam13426
1282356011904	putative active site [active]
1282356011905	heme pocket [chemical binding]; other site
1282356011906	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1282356011907	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1282356011908	metal binding site [ion binding]; metal-binding site
1282356011909	active site
1282356011910	I-site; other site
1282356011911	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1282356011912	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1282356011913	putative DNA binding site [nucleotide binding]; other site
1282356011914	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1282356011915	putative Zn2+ binding site [ion binding]; other site
1282356011916	AsnC family; Region: AsnC_trans_reg; pfam01037
1282356011917	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
1282356011918	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1282356011919	Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576
1282356011920	putative active site [active]
1282356011921	catalytic triad [active]
1282356011922	putative dimer interface [polypeptide binding]; other site
1282356011923	coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110
1282356011924	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1282356011925	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1282356011926	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1282356011927	coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284
1282356011928	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
1282356011929	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
1282356011930	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
1282356011931	pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079
1282356011932	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
1282356011933	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1282356011934	FeS/SAM binding site; other site
1282356011935	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1282356011936	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
1282356011937	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
1282356011938	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
1282356011939	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1282356011940	active site
1282356011941	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
1282356011942	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
1282356011943	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
1282356011944	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1282356011945	active site
1282356011946	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
1282356011947	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1282356011948	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1282356011949	metal binding site [ion binding]; metal-binding site
1282356011950	active site
1282356011951	I-site; other site
1282356011952	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
1282356011953	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
1282356011954	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1282356011955	active site
1282356011956	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
1282356011957	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
1282356011958	AAA domain; Region: AAA_26; pfam13500
1282356011959	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
1282356011960	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356011961	S-adenosylmethionine binding site [chemical binding]; other site
1282356011962	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
1282356011963	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1282356011964	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1282356011965	substrate-cofactor binding pocket; other site
1282356011966	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356011967	catalytic residue [active]
1282356011968	biotin synthase; Provisional; Region: PRK15108
1282356011969	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1282356011970	FeS/SAM binding site; other site
1282356011971	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
1282356011972	comF family protein; Region: comF; TIGR00201
1282356011973	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1282356011974	active site
1282356011975	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
1282356011976	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
1282356011977	molybdenum-pterin binding domain; Region: Mop; TIGR00638
1282356011978	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
1282356011979	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
1282356011980	serine/threonine protein kinase; Provisional; Region: PRK11768
1282356011981	Predicted permeases [General function prediction only]; Region: RarD; COG2962
1282356011982	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
1282356011983	ACT domain; Region: ACT_6; pfam13740
1282356011984	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869
1282356011985	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
1282356011986	active site
1282356011987	Response regulator receiver domain; Region: Response_reg; pfam00072
1282356011988	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356011989	active site
1282356011990	phosphorylation site [posttranslational modification]
1282356011991	intermolecular recognition site; other site
1282356011992	dimerization interface [polypeptide binding]; other site
1282356011993	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
1282356011994	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1282356011995	ligand binding site [chemical binding]; other site
1282356011996	flexible hinge region; other site
1282356011997	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
1282356011998	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1282356011999	metal binding triad; other site
1282356012000	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1282356012001	active site
1282356012002	catalytic site [active]
1282356012003	substrate binding site [chemical binding]; other site
1282356012004	RNA polymerase sigma factor; Reviewed; Region: PRK12523
1282356012005	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1282356012006	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1282356012007	DNA binding residues [nucleotide binding]
1282356012008	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
1282356012009	FecR protein; Region: FecR; pfam04773
1282356012010	Secretin and TonB N terminus short domain; Region: STN; smart00965
1282356012011	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
1282356012012	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1282356012013	N-terminal plug; other site
1282356012014	ligand-binding site [chemical binding]; other site
1282356012015	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1282356012016	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1282356012017	putative glutathione S-transferase; Provisional; Region: PRK10357
1282356012018	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
1282356012019	putative C-terminal domain interface [polypeptide binding]; other site
1282356012020	putative GSH binding site (G-site) [chemical binding]; other site
1282356012021	putative dimer interface [polypeptide binding]; other site
1282356012022	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
1282356012023	dimer interface [polypeptide binding]; other site
1282356012024	N-terminal domain interface [polypeptide binding]; other site
1282356012025	putative substrate binding pocket (H-site) [chemical binding]; other site
1282356012026	inner membrane protein; Provisional; Region: PRK11715
1282356012027	sensory histidine kinase CreC; Provisional; Region: PRK11100
1282356012028	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356012029	dimer interface [polypeptide binding]; other site
1282356012030	phosphorylation site [posttranslational modification]
1282356012031	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356012032	ATP binding site [chemical binding]; other site
1282356012033	Mg2+ binding site [ion binding]; other site
1282356012034	G-X-G motif; other site
1282356012035	DNA-binding response regulator CreB; Provisional; Region: PRK11083
1282356012036	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356012037	active site
1282356012038	phosphorylation site [posttranslational modification]
1282356012039	intermolecular recognition site; other site
1282356012040	dimerization interface [polypeptide binding]; other site
1282356012041	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1282356012042	DNA binding site [nucleotide binding]
1282356012043	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
1282356012044	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1282356012045	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
1282356012046	putative acyl-acceptor binding pocket; other site
1282356012047	Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075
1282356012048	RNA polymerase sigma factor; Provisional; Region: PRK12514
1282356012049	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1282356012050	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1282356012051	DNA binding residues [nucleotide binding]
1282356012052	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343
1282356012053	Anti-sigma-K factor rskA; Region: RskA; pfam10099
1282356012054	Anti-sigma-K factor rskA; Region: RskA; pfam10099
1282356012055	formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819
1282356012056	Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282
1282356012057	NAD binding site [chemical binding]; other site
1282356012058	catalytic Zn binding site [ion binding]; other site
1282356012059	structural Zn binding site [ion binding]; other site
1282356012060	formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011
1282356012061	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
1282356012062	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
1282356012063	putative active site [active]
1282356012064	putative substrate binding site [chemical binding]; other site
1282356012065	putative cosubstrate binding site; other site
1282356012066	catalytic site [active]
1282356012067	Sarcosine oxidase, gamma subunit family; Region: SoxG; pfam04268
1282356012068	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
1282356012069	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
1282356012070	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1282356012071	Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311
1282356012072	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
1282356012073	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1282356012074	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1282356012075	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1282356012076	dimer interface [polypeptide binding]; other site
1282356012077	active site
1282356012078	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1282356012079	folate binding site [chemical binding]; other site
1282356012080	TraX protein; Region: TraX; pfam05857
1282356012081	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
1282356012082	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
1282356012083	tetramer interface [polypeptide binding]; other site
1282356012084	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356012085	catalytic residue [active]
1282356012086	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1282356012087	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
1282356012088	FAD binding pocket [chemical binding]; other site
1282356012089	FAD binding motif [chemical binding]; other site
1282356012090	phosphate binding motif [ion binding]; other site
1282356012091	beta-alpha-beta structure motif; other site
1282356012092	NAD binding pocket [chemical binding]; other site
1282356012093	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1282356012094	catalytic loop [active]
1282356012095	iron binding site [ion binding]; other site
1282356012096	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1282356012097	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1282356012098	[2Fe-2S] cluster binding site [ion binding]; other site
1282356012099	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
1282356012100	putative alpha subunit interface [polypeptide binding]; other site
1282356012101	putative active site [active]
1282356012102	putative substrate binding site [chemical binding]; other site
1282356012103	Fe binding site [ion binding]; other site
1282356012104	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
1282356012105	Ligand Binding Site [chemical binding]; other site
1282356012106	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1282356012107	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985
1282356012108	Ligand binding site [chemical binding]; other site
1282356012109	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1282356012110	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1282356012111	Domain of unknown function (DUF3483); Region: DUF3483; pfam11982
1282356012112	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1282356012113	Cysteine-rich domain; Region: CCG; pfam02754
1282356012114	Cysteine-rich domain; Region: CCG; pfam02754
1282356012115	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
1282356012116	Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734
1282356012117	putative active site [active]
1282356012118	putative FMN binding site [chemical binding]; other site
1282356012119	putative substrate binding site [chemical binding]; other site
1282356012120	putative catalytic residue [active]
1282356012121	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1282356012122	V4R domain; Region: V4R; cl15268
1282356012123	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
1282356012124	Membrane dipeptidase (Peptidase family M19); Region: Peptidase_M19; pfam01244
1282356012125	active site
1282356012126	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
1282356012127	Protein of unknown function (DUF3010); Region: DUF3010; pfam11215
1282356012128	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1282356012129	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
1282356012130	conserved cys residue [active]
1282356012131	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1282356012132	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
1282356012133	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
1282356012134	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
1282356012135	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066
1282356012136	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1282356012137	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1282356012138	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1282356012139	active site
1282356012140	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1282356012141	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
1282356012142	conserved cys residue [active]
1282356012143	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1282356012144	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
1282356012145	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1282356012146	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1282356012147	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
1282356012148	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
1282356012149	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356012150	dimer interface [polypeptide binding]; other site
1282356012151	conserved gate region; other site
1282356012152	putative PBP binding loops; other site
1282356012153	ABC-ATPase subunit interface; other site
1282356012154	choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415
1282356012155	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1282356012156	Walker A/P-loop; other site
1282356012157	ATP binding site [chemical binding]; other site
1282356012158	Q-loop/lid; other site
1282356012159	ABC transporter signature motif; other site
1282356012160	Walker B; other site
1282356012161	D-loop; other site
1282356012162	H-loop/switch region; other site
1282356012163	transcriptional regulator BetI; Validated; Region: PRK00767
1282356012164	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1282356012165	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1282356012166	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
1282356012167	NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090
1282356012168	tetrameric interface [polypeptide binding]; other site
1282356012169	NAD binding site [chemical binding]; other site
1282356012170	catalytic residues [active]
1282356012171	choline dehydrogenase; Validated; Region: PRK02106
1282356012172	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1282356012173	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
1282356012174	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
1282356012175	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1282356012176	putative transporter; Provisional; Region: PRK10504
1282356012177	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356012178	putative substrate translocation pore; other site
1282356012179	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
1282356012180	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1282356012181	ATP binding site [chemical binding]; other site
1282356012182	Mg++ binding site [ion binding]; other site
1282356012183	motif III; other site
1282356012184	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1282356012185	nucleotide binding region [chemical binding]; other site
1282356012186	ATP-binding site [chemical binding]; other site
1282356012187	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
1282356012188	putative RNA binding site [nucleotide binding]; other site
1282356012189	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1282356012190	HI0933-like protein; Region: HI0933_like; pfam03486
1282356012191	NAD binding site [chemical binding]; other site
1282356012192	integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667
1282356012193	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
1282356012194	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1282356012195	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1282356012196	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1282356012197	substrate binding pocket [chemical binding]; other site
1282356012198	membrane-bound complex binding site; other site
1282356012199	hinge residues; other site
1282356012200	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1282356012201	Coenzyme A binding pocket [chemical binding]; other site
1282356012202	Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; cl11547
1282356012203	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
1282356012204	Response regulator receiver domain; Region: Response_reg; pfam00072
1282356012205	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356012206	active site
1282356012207	phosphorylation site [posttranslational modification]
1282356012208	intermolecular recognition site; other site
1282356012209	dimerization interface [polypeptide binding]; other site
1282356012210	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356012211	PAS domain; Region: PAS_9; pfam13426
1282356012212	putative active site [active]
1282356012213	heme pocket [chemical binding]; other site
1282356012214	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1282356012215	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1282356012216	metal binding site [ion binding]; metal-binding site
1282356012217	active site
1282356012218	I-site; other site
1282356012219	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1282356012220	Alginate lyase; Region: Alginate_lyase2; pfam08787
1282356012221	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1282356012222	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1282356012223	intersubunit interface [polypeptide binding]; other site
1282356012224	active site
1282356012225	zinc binding site [ion binding]; other site
1282356012226	Na+ binding site [ion binding]; other site
1282356012227	lysozyme inhibitor; Provisional; Region: PRK11372
1282356012228	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
1282356012229	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
1282356012230	Phosphoglycerate kinase; Region: PGK; pfam00162
1282356012231	substrate binding site [chemical binding]; other site
1282356012232	hinge regions; other site
1282356012233	ADP binding site [chemical binding]; other site
1282356012234	catalytic site [active]
1282356012235	erythrose-4-phosphate dehydrogenase; Region: E4PD_g-proteo; TIGR01532
1282356012236	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1282356012237	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1282356012238	transketolase; Reviewed; Region: PRK12753
1282356012239	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1282356012240	TPP-binding site [chemical binding]; other site
1282356012241	dimer interface [polypeptide binding]; other site
1282356012242	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1282356012243	PYR/PP interface [polypeptide binding]; other site
1282356012244	dimer interface [polypeptide binding]; other site
1282356012245	TPP binding site [chemical binding]; other site
1282356012246	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1282356012247	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1282356012248	putative DNA binding site [nucleotide binding]; other site
1282356012249	dimerization interface [polypeptide binding]; other site
1282356012250	putative Zn2+ binding site [ion binding]; other site
1282356012251	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1282356012252	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356012253	S-adenosylmethionine binding site [chemical binding]; other site
1282356012254	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1282356012255	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1282356012256	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1282356012257	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1282356012258	NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097
1282356012259	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
1282356012260	nucleotide binding pocket [chemical binding]; other site
1282356012261	K-X-D-G motif; other site
1282356012262	catalytic site [active]
1282356012263	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1282356012264	Protein of unknown function (DUF1090); Region: DUF1090; pfam06476
1282356012265	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
1282356012266	MltA specific insert domain; Region: MltA; smart00925
1282356012267	3D domain; Region: 3D; pfam06725
1282356012268	Predicted membrane protein [Function unknown]; Region: COG3686
1282356012269	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1282356012270	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1282356012271	Domain of unknown function (DUF1837); Region: DUF1837; pfam08878
1282356012272	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1282356012273	ATP binding site [chemical binding]; other site
1282356012274	putative Mg++ binding site [ion binding]; other site
1282356012275	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1282356012276	nucleotide binding region [chemical binding]; other site
1282356012277	ATP-binding site [chemical binding]; other site
1282356012278	Protein of unknown function (DUF808); Region: DUF808; cl01002
1282356012279	Y-family of DNA polymerases; Region: PolY; cl12025
1282356012280	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1282356012281	Ion channel; Region: Ion_trans_2; pfam07885
1282356012282	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1282356012283	Family description; Region: UvrD_C_2; pfam13538
1282356012284	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
1282356012285	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1282356012286	catalytic core [active]
1282356012287	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1282356012288	sequence-specific DNA binding site [nucleotide binding]; other site
1282356012289	salt bridge; other site
1282356012290	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1282356012291	DNA binding site [nucleotide binding]
1282356012292	Int/Topo IB signature motif; other site
1282356012293	active site
1282356012294	catalytic residues [active]
1282356012295	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1282356012296	active site
1282356012297	DNA binding site [nucleotide binding]
1282356012298	Int/Topo IB signature motif; other site
1282356012299	Splicing factor [RNA processing and modification]; Region: PRP40; COG5104
1282356012300	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1282356012301	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
1282356012302	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1282356012303	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
1282356012304	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
1282356012305	homotetramer interface [polypeptide binding]; other site
1282356012306	ligand binding site [chemical binding]; other site
1282356012307	catalytic site [active]
1282356012308	NAD binding site [chemical binding]; other site
1282356012309	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1282356012310	FAD binding site [chemical binding]; other site
1282356012311	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1282356012312	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1282356012313	substrate binding pocket [chemical binding]; other site
1282356012314	membrane-bound complex binding site; other site
1282356012315	hinge residues; other site
1282356012316	helicase 45; Provisional; Region: PTZ00424
1282356012317	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1282356012318	ATP binding site [chemical binding]; other site
1282356012319	Mg++ binding site [ion binding]; other site
1282356012320	motif III; other site
1282356012321	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1282356012322	nucleotide binding region [chemical binding]; other site
1282356012323	ATP-binding site [chemical binding]; other site
1282356012324	hypothetical protein; Provisional; Region: PRK03757
1282356012325	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
1282356012326	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK07030
1282356012327	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1282356012328	inhibitor-cofactor binding pocket; inhibition site
1282356012329	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356012330	catalytic residue [active]
1282356012331	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
1282356012332	RNA methyltransferase, RsmE family; Region: TIGR00046
1282356012333	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
1282356012334	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1282356012335	substrate binding pocket [chemical binding]; other site
1282356012336	membrane-bound complex binding site; other site
1282356012337	hinge residues; other site
1282356012338	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015
1282356012339	putative active site [active]
1282356012340	homotrimer interaction site [polypeptide binding]; other site
1282356012341	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
1282356012342	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1282356012343	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1282356012344	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356012345	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356012346	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1282356012347	dimerization interface [polypeptide binding]; other site
1282356012348	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
1282356012349	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1282356012350	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356012351	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356012352	The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416
1282356012353	putative dimerization interface [polypeptide binding]; other site
1282356012354	malonate transporter, MadM subunit; Region: malonate_madM; TIGR00808
1282356012355	Malonate transporter MadL subunit; Region: MadL; cl04273
1282356012356	malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131
1282356012357	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1282356012358	phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293
1282356012359	Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620
1282356012360	malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134
1282356012361	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189
1282356012362	malonate decarboxylase subunit delta; Provisional; Region: PRK01220
1282356012363	triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237
1282356012364	malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110
1282356012365	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
1282356012366	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1282356012367	putative binding surface; other site
1282356012368	active site
1282356012369	Hpt domain; Region: Hpt; pfam01627
1282356012370	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
1282356012371	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1282356012372	putative binding surface; other site
1282356012373	active site
1282356012374	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1282356012375	putative binding surface; other site
1282356012376	active site
1282356012377	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
1282356012378	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356012379	ATP binding site [chemical binding]; other site
1282356012380	Mg2+ binding site [ion binding]; other site
1282356012381	G-X-G motif; other site
1282356012382	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
1282356012383	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356012384	Response regulator receiver domain; Region: Response_reg; pfam00072
1282356012385	active site
1282356012386	phosphorylation site [posttranslational modification]
1282356012387	intermolecular recognition site; other site
1282356012388	dimerization interface [polypeptide binding]; other site
1282356012389	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
1282356012390	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1282356012391	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356012392	dimer interface [polypeptide binding]; other site
1282356012393	putative CheW interface [polypeptide binding]; other site
1282356012394	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
1282356012395	Response regulator receiver domain; Region: Response_reg; pfam00072
1282356012396	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356012397	active site
1282356012398	phosphorylation site [posttranslational modification]
1282356012399	intermolecular recognition site; other site
1282356012400	dimerization interface [polypeptide binding]; other site
1282356012401	Response regulator receiver domain; Region: Response_reg; pfam00072
1282356012402	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356012403	active site
1282356012404	phosphorylation site [posttranslational modification]
1282356012405	intermolecular recognition site; other site
1282356012406	dimerization interface [polypeptide binding]; other site
1282356012407	glutathione synthetase; Provisional; Region: PRK05246
1282356012408	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
1282356012409	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
1282356012410	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
1282356012411	Phosphoprotein; Region: PP_M1; pfam03012
1282356012412	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
1282356012413	hypothetical protein; Validated; Region: PRK00228
1282356012414	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
1282356012415	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1282356012416	active site
1282356012417	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1282356012418	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1282356012419	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1282356012420	dihydroorotase; Validated; Region: pyrC; PRK09357
1282356012421	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1282356012422	active site
1282356012423	TM2 domain; Region: TM2; cl00984
1282356012424	TM2 domain; Region: TM2; cl00984
1282356012425	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1282356012426	NlpC/P60 family; Region: NLPC_P60; pfam00877
1282356012427	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
1282356012428	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
1282356012429	Walker A motif; other site
1282356012430	ATP binding site [chemical binding]; other site
1282356012431	Walker B motif; other site
1282356012432	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
1282356012433	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1282356012434	catalytic residue [active]
1282356012435	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
1282356012436	pyrroline-5-carboxylate reductase; Region: PLN02688
1282356012437	YGGT family; Region: YGGT; pfam02325
1282356012438	YGGT family; Region: YGGT; pfam02325
1282356012439	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
1282356012440	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
1282356012441	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1282356012442	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356012443	S-adenosylmethionine binding site [chemical binding]; other site
1282356012444	Domain of unknown function (DUF4426); Region: DUF4426; pfam14467
1282356012445	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1282356012446	active site
1282356012447	dimerization interface [polypeptide binding]; other site
1282356012448	HemN family oxidoreductase; Provisional; Region: PRK05660
1282356012449	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1282356012450	FeS/SAM binding site; other site
1282356012451	HemN C-terminal domain; Region: HemN_C; pfam06969
1282356012452	Protein of unknown function (DUF3392); Region: DUF3392; pfam11872
1282356012453	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356012454	S-adenosylmethionine binding site [chemical binding]; other site
1282356012455	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
1282356012456	ThiS interaction site; other site
1282356012457	putative active site [active]
1282356012458	tetramer interface [polypeptide binding]; other site
1282356012459	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
1282356012460	thiS-thiF/thiG interaction site; other site
1282356012461	Protein of unknown function (DUF423); Region: DUF423; pfam04241
1282356012462	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
1282356012463	Transglycosylase; Region: Transgly; cl17702
1282356012464	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
1282356012465	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1282356012466	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1282356012467	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1282356012468	DNA binding residues [nucleotide binding]
1282356012469	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
1282356012470	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
1282356012471	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
1282356012472	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1282356012473	Walker A/P-loop; other site
1282356012474	ATP binding site [chemical binding]; other site
1282356012475	Q-loop/lid; other site
1282356012476	ABC transporter signature motif; other site
1282356012477	Walker B; other site
1282356012478	D-loop; other site
1282356012479	H-loop/switch region; other site
1282356012480	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1282356012481	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1282356012482	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1282356012483	P loop; other site
1282356012484	GTP binding site [chemical binding]; other site
1282356012485	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1282356012486	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1282356012487	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1282356012488	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1282356012489	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1282356012490	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
1282356012491	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356012492	S-adenosylmethionine binding site [chemical binding]; other site
1282356012493	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
1282356012494	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1282356012495	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1282356012496	active site residue [active]
1282356012497	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1282356012498	active site residue [active]
1282356012499	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1282356012500	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1282356012501	Bacterial transcriptional repressor; Region: TetR; pfam13972
1282356012502	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
1282356012503	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
1282356012504	NAD(P) binding site [chemical binding]; other site
1282356012505	catalytic residues [active]
1282356012506	GMC oxidoreductase; Region: GMC_oxred_N; pfam00732
1282356012507	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1282356012508	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1282356012509	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1282356012510	active site
1282356012511	(T/H)XGH motif; other site
1282356012512	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1282356012513	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1282356012514	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1282356012515	DNA binding site [nucleotide binding]
1282356012516	catalytic residue [active]
1282356012517	H2TH interface [polypeptide binding]; other site
1282356012518	putative catalytic residues [active]
1282356012519	turnover-facilitating residue; other site
1282356012520	intercalation triad [nucleotide binding]; other site
1282356012521	8OG recognition residue [nucleotide binding]; other site
1282356012522	putative reading head residues; other site
1282356012523	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1282356012524	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1282356012525	Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639
1282356012526	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
1282356012527	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
1282356012528	putative RNA binding site [nucleotide binding]; other site
1282356012529	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356012530	S-adenosylmethionine binding site [chemical binding]; other site
1282356012531	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
1282356012532	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
1282356012533	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1282356012534	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1282356012535	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1282356012536	folate binding site [chemical binding]; other site
1282356012537	NADP+ binding site [chemical binding]; other site
1282356012538	Protein of unknown function (DUF2868); Region: DUF2868; pfam11067
1282356012539	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1282356012540	G1 box; other site
1282356012541	GTP/Mg2+ binding site [chemical binding]; other site
1282356012542	G2 box; other site
1282356012543	Switch I region; other site
1282356012544	G3 box; other site
1282356012545	Switch II region; other site
1282356012546	G4 box; other site
1282356012547	Domain of unknown function (DUF3482); Region: DUF3482; pfam11981
1282356012548	G5 box; other site
1282356012549	phosphonate degradation operons associated HDIG domain protein; Region: Phn-HD; TIGR03276
1282356012550	FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed
1282356012551	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1282356012552	putative 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate-binding protein; Region: phnS2; TIGR03261
1282356012553	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1282356012554	putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262
1282356012555	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356012556	dimer interface [polypeptide binding]; other site
1282356012557	conserved gate region; other site
1282356012558	putative PBP binding loops; other site
1282356012559	ABC-ATPase subunit interface; other site
1282356012560	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356012561	dimer interface [polypeptide binding]; other site
1282356012562	conserved gate region; other site
1282356012563	putative PBP binding loops; other site
1282356012564	ABC-ATPase subunit interface; other site
1282356012565	putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265
1282356012566	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1282356012567	Walker A/P-loop; other site
1282356012568	ATP binding site [chemical binding]; other site
1282356012569	Q-loop/lid; other site
1282356012570	ABC transporter signature motif; other site
1282356012571	Walker B; other site
1282356012572	D-loop; other site
1282356012573	H-loop/switch region; other site
1282356012574	TOBE domain; Region: TOBE_2; pfam08402
1282356012575	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
1282356012576	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356012577	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1282356012578	dimerization interface [polypeptide binding]; other site
1282356012579	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1282356012580	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1282356012581	metal-binding site [ion binding]
1282356012582	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1282356012583	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1282356012584	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
1282356012585	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
1282356012586	DNA binding residues [nucleotide binding]
1282356012587	dimer interface [polypeptide binding]; other site
1282356012588	putative metal binding site [ion binding]; other site
1282356012589	thymidylate synthase; Reviewed; Region: thyA; PRK01827
1282356012590	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1282356012591	dimerization interface [polypeptide binding]; other site
1282356012592	active site
1282356012593	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
1282356012594	NRDE protein; Region: NRDE; cl01315
1282356012595	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
1282356012596	GAF domain; Region: GAF; pfam01590
1282356012597	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1282356012598	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1282356012599	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1282356012600	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
1282356012601	putative active site [active]
1282356012602	Ap4A binding site [chemical binding]; other site
1282356012603	nudix motif; other site
1282356012604	putative metal binding site [ion binding]; other site
1282356012605	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1282356012606	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1282356012607	Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027
1282356012608	threonine dehydratase; Reviewed; Region: PRK09224
1282356012609	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1282356012610	tetramer interface [polypeptide binding]; other site
1282356012611	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356012612	catalytic residue [active]
1282356012613	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
1282356012614	putative Ile/Val binding site [chemical binding]; other site
1282356012615	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
1282356012616	putative Ile/Val binding site [chemical binding]; other site
1282356012617	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
1282356012618	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1282356012619	active site
1282356012620	dimer interface [polypeptide binding]; other site
1282356012621	SdiA-regulated; Region: SdiA-regulated; pfam06977
1282356012622	SdiA-regulated; Region: SdiA-regulated; cd09971
1282356012623	putative active site [active]
1282356012624	SdiA-regulated; Region: SdiA-regulated; pfam06977
1282356012625	SdiA-regulated; Region: SdiA-regulated; cd09971
1282356012626	putative active site [active]
1282356012627	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
1282356012628	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1282356012629	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1282356012630	FAD binding domain; Region: FAD_binding_4; pfam01565
1282356012631	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
1282356012632	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
1282356012633	ligand binding site [chemical binding]; other site
1282356012634	NAD binding site [chemical binding]; other site
1282356012635	tetramer interface [polypeptide binding]; other site
1282356012636	catalytic site [active]
1282356012637	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
1282356012638	L-serine binding site [chemical binding]; other site
1282356012639	ACT domain interface; other site
1282356012640	Domain of unknown function (DUF4399); Region: DUF4399; pfam14347
1282356012641	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1282356012642	substrate binding pocket [chemical binding]; other site
1282356012643	Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702
1282356012644	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
1282356012645	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1282356012646	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1282356012647	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
1282356012648	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
1282356012649	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1282356012650	Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011
1282356012651	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
1282356012652	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
1282356012653	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
1282356012654	active site
1282356012655	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1282356012656	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356012657	dimer interface [polypeptide binding]; other site
1282356012658	conserved gate region; other site
1282356012659	putative PBP binding loops; other site
1282356012660	ABC-ATPase subunit interface; other site
1282356012661	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356012662	dimer interface [polypeptide binding]; other site
1282356012663	conserved gate region; other site
1282356012664	putative PBP binding loops; other site
1282356012665	ABC-ATPase subunit interface; other site
1282356012666	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
1282356012667	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1282356012668	Walker A/P-loop; other site
1282356012669	ATP binding site [chemical binding]; other site
1282356012670	Q-loop/lid; other site
1282356012671	ABC transporter signature motif; other site
1282356012672	Walker B; other site
1282356012673	D-loop; other site
1282356012674	H-loop/switch region; other site
1282356012675	TOBE domain; Region: TOBE_2; pfam08402
1282356012676	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
1282356012677	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1282356012678	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
1282356012679	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1282356012680	putative aminotransferase; Validated; Region: PRK07480
1282356012681	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1282356012682	inhibitor-cofactor binding pocket; inhibition site
1282356012683	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356012684	catalytic residue [active]
1282356012685	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1282356012686	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1282356012687	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1282356012688	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1282356012689	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1282356012690	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1282356012691	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
1282356012692	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
1282356012693	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1282356012694	Walker A/P-loop; other site
1282356012695	ATP binding site [chemical binding]; other site
1282356012696	Q-loop/lid; other site
1282356012697	ABC transporter signature motif; other site
1282356012698	Walker B; other site
1282356012699	D-loop; other site
1282356012700	H-loop/switch region; other site
1282356012701	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1282356012702	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356012703	dimer interface [polypeptide binding]; other site
1282356012704	conserved gate region; other site
1282356012705	putative PBP binding loops; other site
1282356012706	ABC-ATPase subunit interface; other site
1282356012707	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
1282356012708	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
1282356012709	active site
1282356012710	dimer interface [polypeptide binding]; other site
1282356012711	non-prolyl cis peptide bond; other site
1282356012712	insertion regions; other site
1282356012713	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1282356012714	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1282356012715	substrate binding pocket [chemical binding]; other site
1282356012716	membrane-bound complex binding site; other site
1282356012717	hinge residues; other site
1282356012718	NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569
1282356012719	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1282356012720	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1282356012721	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
1282356012722	dimer interface [polypeptide binding]; other site
1282356012723	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1282356012724	catalytic triad [active]
1282356012725	outer membrane porin, OprD family; Region: OprD; pfam03573
1282356012726	N-acetylglutamate synthase; Validated; Region: PRK05279
1282356012727	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
1282356012728	putative feedback inhibition sensing region; other site
1282356012729	putative nucleotide binding site [chemical binding]; other site
1282356012730	putative substrate binding site [chemical binding]; other site
1282356012731	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1282356012732	Coenzyme A binding pocket [chemical binding]; other site
1282356012733	acetylornithine deacetylase; Provisional; Region: PRK05111
1282356012734	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
1282356012735	metal binding site [ion binding]; metal-binding site
1282356012736	putative dimer interface [polypeptide binding]; other site
1282356012737	Uncharacterized conserved protein [Function unknown]; Region: COG3025
1282356012738	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
1282356012739	putative active site [active]
1282356012740	putative metal binding residues [ion binding]; other site
1282356012741	signature motif; other site
1282356012742	putative triphosphate binding site [ion binding]; other site
1282356012743	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1282356012744	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1282356012745	putative DNA binding site [nucleotide binding]; other site
1282356012746	putative Zn2+ binding site [ion binding]; other site
1282356012747	AsnC family; Region: AsnC_trans_reg; pfam01037
1282356012748	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
1282356012749	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
1282356012750	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1282356012751	Walker A motif; other site
1282356012752	ATP binding site [chemical binding]; other site
1282356012753	Walker B motif; other site
1282356012754	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1282356012755	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
1282356012756	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
1282356012757	conserverd hypothetical protein; Region: TIGR02448
1282356012758	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1282356012759	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1282356012760	inhibitor-cofactor binding pocket; inhibition site
1282356012761	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356012762	catalytic residue [active]
1282356012763	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1282356012764	lipoyl attachment site [posttranslational modification]; other site
1282356012765	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
1282356012766	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1282356012767	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1282356012768	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356012769	dimer interface [polypeptide binding]; other site
1282356012770	conserved gate region; other site
1282356012771	putative PBP binding loops; other site
1282356012772	ABC-ATPase subunit interface; other site
1282356012773	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1282356012774	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1282356012775	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1282356012776	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1282356012777	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK05714
1282356012778	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732
1282356012779	2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984
1282356012780	proline aminopeptidase P II; Provisional; Region: PRK10879
1282356012781	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
1282356012782	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
1282356012783	active site
1282356012784	hypothetical protein; Reviewed; Region: PRK02166
1282356012785	TIGR02449 family protein; Region: TIGR02449
1282356012786	Cell division protein ZapA; Region: ZapA; pfam05164
1282356012787	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
1282356012788	EVE domain; Region: EVE; cl00728
1282356012789	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1282356012790	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
1282356012791	flagellar basal body-associated protein FliL-like protein; Validated; Region: PRK05697
1282356012792	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
1282356012793	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1282356012794	NAD(P) binding site [chemical binding]; other site
1282356012795	sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
1282356012796	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356012797	putative substrate translocation pore; other site
1282356012798	Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703
1282356012799	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1282356012800	putative active site pocket [active]
1282356012801	dimerization interface [polypeptide binding]; other site
1282356012802	putative catalytic residue [active]
1282356012803	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
1282356012804	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1282356012805	catalytic loop [active]
1282356012806	iron binding site [ion binding]; other site
1282356012807	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
1282356012808	FAD binding pocket [chemical binding]; other site
1282356012809	FAD binding motif [chemical binding]; other site
1282356012810	phosphate binding motif [ion binding]; other site
1282356012811	beta-alpha-beta structure motif; other site
1282356012812	NAD binding pocket [chemical binding]; other site
1282356012813	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
1282356012814	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1282356012815	transcription termination factor Rho; Provisional; Region: rho; PRK09376
1282356012816	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
1282356012817	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
1282356012818	RNA binding site [nucleotide binding]; other site
1282356012819	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1282356012820	multimer interface [polypeptide binding]; other site
1282356012821	Walker A motif; other site
1282356012822	ATP binding site [chemical binding]; other site
1282356012823	Walker B motif; other site
1282356012824	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1282356012825	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1282356012826	catalytic residues [active]
1282356012827	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1282356012828	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1282356012829	DNA-binding site [nucleotide binding]; DNA binding site
1282356012830	FCD domain; Region: FCD; pfam07729
1282356012831	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1282356012832	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1282356012833	substrate binding pocket [chemical binding]; other site
1282356012834	membrane-bound complex binding site; other site
1282356012835	hinge residues; other site
1282356012836	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1282356012837	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356012838	dimer interface [polypeptide binding]; other site
1282356012839	conserved gate region; other site
1282356012840	putative PBP binding loops; other site
1282356012841	ABC-ATPase subunit interface; other site
1282356012842	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356012843	dimer interface [polypeptide binding]; other site
1282356012844	conserved gate region; other site
1282356012845	putative PBP binding loops; other site
1282356012846	ABC-ATPase subunit interface; other site
1282356012847	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1282356012848	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1282356012849	Walker A/P-loop; other site
1282356012850	ATP binding site [chemical binding]; other site
1282356012851	Q-loop/lid; other site
1282356012852	ABC transporter signature motif; other site
1282356012853	Walker B; other site
1282356012854	D-loop; other site
1282356012855	H-loop/switch region; other site
1282356012856	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
1282356012857	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1282356012858	polyphosphate kinase; Provisional; Region: PRK05443
1282356012859	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
1282356012860	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
1282356012861	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1282356012862	putative active site [active]
1282356012863	catalytic site [active]
1282356012864	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
1282356012865	putative domain interface [polypeptide binding]; other site
1282356012866	putative active site [active]
1282356012867	catalytic site [active]
1282356012868	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
1282356012869	dimer interface [polypeptide binding]; other site
1282356012870	active site
1282356012871	aspartate-rich active site metal binding site; other site
1282356012872	allosteric magnesium binding site [ion binding]; other site
1282356012873	Schiff base residues; other site
1282356012874	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1282356012875	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1282356012876	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
1282356012877	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
1282356012878	conserved cys residue [active]
1282356012879	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671
1282356012880	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1282356012881	Cytochrome c; Region: Cytochrom_C; pfam00034
1282356012882	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
1282356012883	LysE type translocator; Region: LysE; cl00565
1282356012884	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1282356012885	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1282356012886	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
1282356012887	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1282356012888	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1282356012889	ABC transporter; Region: ABC_tran_2; pfam12848
1282356012890	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1282356012891	Protein of unknown function (DUF2390); Region: DUF2390; pfam09523
1282356012892	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
1282356012893	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
1282356012894	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1282356012895	anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718
1282356012896	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
1282356012897	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
1282356012898	HemY protein N-terminus; Region: HemY_N; pfam07219
1282356012899	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
1282356012900	uroporphyrinogen-III synthase; Validated; Region: PRK05752
1282356012901	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1282356012902	active site
1282356012903	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1282356012904	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
1282356012905	domain interfaces; other site
1282356012906	active site
1282356012907	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1282356012908	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356012909	active site
1282356012910	phosphorylation site [posttranslational modification]
1282356012911	intermolecular recognition site; other site
1282356012912	dimerization interface [polypeptide binding]; other site
1282356012913	LytTr DNA-binding domain; Region: LytTR; pfam04397
1282356012914	argininosuccinate lyase; Provisional; Region: PRK00855
1282356012915	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1282356012916	active sites [active]
1282356012917	tetramer interface [polypeptide binding]; other site
1282356012918	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1282356012919	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
1282356012920	C-terminal domain interface [polypeptide binding]; other site
1282356012921	GSH binding site (G-site) [chemical binding]; other site
1282356012922	dimer interface [polypeptide binding]; other site
1282356012923	C-terminal, alpha helical domain of an unknown subfamily 9 of Glutathione S-transferases; Region: GST_C_9; cd10424
1282356012924	putative N-terminal domain interface [polypeptide binding]; other site
1282356012925	putative dimer interface [polypeptide binding]; other site
1282356012926	putative substrate binding pocket (H-site) [chemical binding]; other site
1282356012927	TIGR02647 family protein; Region: DNA
1282356012928	adenylate cyclase; Provisional; Region: cyaA; PRK09450
1282356012929	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
1282356012930	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
1282356012931	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
1282356012932	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1282356012933	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
1282356012934	frataxin-like protein; Provisional; Region: cyaY; PRK00446
1282356012935	putative iron binding site [ion binding]; other site
1282356012936	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361
1282356012937	diaminopimelate decarboxylase; Region: lysA; TIGR01048
1282356012938	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1282356012939	active site
1282356012940	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1282356012941	substrate binding site [chemical binding]; other site
1282356012942	catalytic residues [active]
1282356012943	dimer interface [polypeptide binding]; other site
1282356012944	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
1282356012945	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1282356012946	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1282356012947	Protein of unknown function, DUF484; Region: DUF484; cl17449
1282356012948	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
1282356012949	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1282356012950	active site
1282356012951	DNA binding site [nucleotide binding]
1282356012952	Int/Topo IB signature motif; other site
1282356012953	flavin mononucleotide phosphatase; Provisional; Region: PRK10748
1282356012954	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1282356012955	motif II; other site
1282356012956	Uncharacterized conserved protein [Function unknown]; Region: COG0432
1282356012957	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1282356012958	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
1282356012959	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1282356012960	Membrane fusogenic activity; Region: BMFP; pfam04380
1282356012961	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1282356012962	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1282356012963	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1282356012964	catalytic residues [active]
1282356012965	catalytic nucleophile [active]
1282356012966	Recombinase; Region: Recombinase; pfam07508
1282356012967	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
1282356012968	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
1282356012969	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1282356012970	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
1282356012971	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
1282356012972	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1282356012973	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1282356012974	dimerization interface [polypeptide binding]; other site
1282356012975	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356012976	dimer interface [polypeptide binding]; other site
1282356012977	putative CheW interface [polypeptide binding]; other site
1282356012978	multidrug efflux protein NorA; Provisional; Region: PRK00187
1282356012979	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
1282356012980	cation binding site [ion binding]; other site
1282356012981	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1282356012982	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1282356012983	metal binding site [ion binding]; metal-binding site
1282356012984	active site
1282356012985	I-site; other site
1282356012986	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1282356012987	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
1282356012988	Part of AAA domain; Region: AAA_19; pfam13245
1282356012989	Family description; Region: UvrD_C_2; pfam13538
1282356012990	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1282356012991	active site
1282356012992	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
1282356012993	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
1282356012994	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
1282356012995	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
1282356012996	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1282356012997	non-specific DNA binding site [nucleotide binding]; other site
1282356012998	salt bridge; other site
1282356012999	sequence-specific DNA binding site [nucleotide binding]; other site
1282356013000	Cupin domain; Region: Cupin_2; pfam07883
1282356013001	alanine racemase; Reviewed; Region: dadX; PRK03646
1282356013002	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
1282356013003	active site
1282356013004	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1282356013005	substrate binding site [chemical binding]; other site
1282356013006	catalytic residues [active]
1282356013007	dimer interface [polypeptide binding]; other site
1282356013008	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
1282356013009	homotrimer interaction site [polypeptide binding]; other site
1282356013010	putative active site [active]
1282356013011	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
1282356013012	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1282356013013	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1282356013014	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
1282356013015	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1282356013016	putative DNA binding site [nucleotide binding]; other site
1282356013017	putative Zn2+ binding site [ion binding]; other site
1282356013018	AsnC family; Region: AsnC_trans_reg; pfam01037
1282356013019	Flagellin N-methylase; Region: FliB; pfam03692
1282356013020	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1282356013021	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1282356013022	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
1282356013023	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1282356013024	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1282356013025	DNA-binding site [nucleotide binding]; DNA binding site
1282356013026	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1282356013027	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356013028	homodimer interface [polypeptide binding]; other site
1282356013029	catalytic residue [active]
1282356013030	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
1282356013031	PLD-like domain; Region: PLDc_2; pfam13091
1282356013032	putative active site [active]
1282356013033	catalytic site [active]
1282356013034	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
1282356013035	PLD-like domain; Region: PLDc_2; pfam13091
1282356013036	putative active site [active]
1282356013037	catalytic site [active]
1282356013038	gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847
1282356013039	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
1282356013040	NAD(P) binding site [chemical binding]; other site
1282356013041	catalytic residues [active]
1282356013042	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
1282356013043	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1282356013044	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1282356013045	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
1282356013046	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1282356013047	peptide binding site [polypeptide binding]; other site
1282356013048	hypothetical protein; Reviewed; Region: PRK00024
1282356013049	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1282356013050	MPN+ (JAMM) motif; other site
1282356013051	Zinc-binding site [ion binding]; other site
1282356013052	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1282356013053	Flavoprotein; Region: Flavoprotein; pfam02441
1282356013054	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1282356013055	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1282356013056	trimer interface [polypeptide binding]; other site
1282356013057	active site
1282356013058	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
1282356013059	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
1282356013060	active site
1282356013061	substrate binding site [chemical binding]; other site
1282356013062	metal binding site [ion binding]; metal-binding site
1282356013063	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
1282356013064	feedback inhibition sensing region; other site
1282356013065	homohexameric interface [polypeptide binding]; other site
1282356013066	nucleotide binding site [chemical binding]; other site
1282356013067	N-acetyl-L-glutamate binding site [chemical binding]; other site
1282356013068	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1282356013069	active site
1282356013070	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
1282356013071	putative active site [active]
1282356013072	putative catalytic site [active]
1282356013073	putative DNA binding site [nucleotide binding]; other site
1282356013074	putative phosphate binding site [ion binding]; other site
1282356013075	metal binding site A [ion binding]; metal-binding site
1282356013076	putative AP binding site [nucleotide binding]; other site
1282356013077	putative metal binding site B [ion binding]; other site
1282356013078	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296
1282356013079	ribonuclease PH; Reviewed; Region: rph; PRK00173
1282356013080	Ribonuclease PH; Region: RNase_PH_bact; cd11362
1282356013081	hexamer interface [polypeptide binding]; other site
1282356013082	active site
1282356013083	hypothetical protein; Provisional; Region: PRK11820
1282356013084	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
1282356013085	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
1282356013086	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1282356013087	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1282356013088	catalytic site [active]
1282356013089	G-X2-G-X-G-K; other site
1282356013090	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
1282356013091	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
1282356013092	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1282356013093	Zn2+ binding site [ion binding]; other site
1282356013094	Mg2+ binding site [ion binding]; other site
1282356013095	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1282356013096	synthetase active site [active]
1282356013097	NTP binding site [chemical binding]; other site
1282356013098	metal binding site [ion binding]; metal-binding site
1282356013099	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1282356013100	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1282356013101	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1282356013102	homotrimer interaction site [polypeptide binding]; other site
1282356013103	putative active site [active]
1282356013104	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1282356013105	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
1282356013106	putative NAD(P) binding site [chemical binding]; other site
1282356013107	tonB-system energizer ExbB; Region: exbB; TIGR02797
1282356013108	biopolymer transport protein ExbD; Provisional; Region: PRK11267
1282356013109	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1282356013110	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
1282356013111	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
1282356013112	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
1282356013113	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356013114	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
1282356013115	dimerization interface [polypeptide binding]; other site
1282356013116	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1282356013117	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1282356013118	generic binding surface II; other site
1282356013119	ssDNA binding site; other site
1282356013120	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1282356013121	ATP binding site [chemical binding]; other site
1282356013122	putative Mg++ binding site [ion binding]; other site
1282356013123	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1282356013124	nucleotide binding region [chemical binding]; other site
1282356013125	ATP-binding site [chemical binding]; other site
1282356013126	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
1282356013127	putative deacylase active site [active]
1282356013128	Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639
1282356013129	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1282356013130	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1282356013131	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1282356013132	Walker A/P-loop; other site
1282356013133	ATP binding site [chemical binding]; other site
1282356013134	Q-loop/lid; other site
1282356013135	ABC transporter signature motif; other site
1282356013136	Walker B; other site
1282356013137	D-loop; other site
1282356013138	H-loop/switch region; other site
1282356013139	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1282356013140	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1282356013141	active site
1282356013142	ATP binding site [chemical binding]; other site
1282356013143	substrate binding site [chemical binding]; other site
1282356013144	activation loop (A-loop); other site
1282356013145	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1282356013146	metal ion-dependent adhesion site (MIDAS); other site
1282356013147	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1282356013148	Protein phosphatase 2C; Region: PP2C; pfam00481
1282356013149	active site
1282356013150	Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867
1282356013151	type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348
1282356013152	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
1282356013153	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
1282356013154	hypothetical protein; Provisional; Region: PRK07033
1282356013155	Type VI protein secretion system component VasF [Intracellular    trafficking, secretion, and vesicular transport]; Region: COG3455
1282356013156	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1282356013157	ligand binding site [chemical binding]; other site
1282356013158	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3522
1282356013159	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
1282356013160	type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352
1282356013161	type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354
1282356013162	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1282356013163	phosphopeptide binding site; other site
1282356013164	type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363
1282356013165	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
1282356013166	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3516
1282356013167	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517
1282356013168	Protein of unknown function (DUF877); Region: DUF877; pfam05943
1282356013169	Protein of unknown function (DUF796); Region: DUF796; pfam05638
1282356013170	Domain of unknown function (DUF4285); Region: DUF4285; pfam14113
1282356013171	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3518
1282356013172	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
1282356013173	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
1282356013174	Protein of unknown function (DUF1305); Region: DUF1305; pfam06996
1282356013175	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
1282356013176	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356013177	Walker A motif; other site
1282356013178	ATP binding site [chemical binding]; other site
1282356013179	Walker B motif; other site
1282356013180	arginine finger; other site
1282356013181	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356013182	Walker A motif; other site
1282356013183	ATP binding site [chemical binding]; other site
1282356013184	Walker B motif; other site
1282356013185	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1282356013186	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
1282356013187	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
1282356013188	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
1282356013189	Domain of unknown function (DUF1795); Region: DUF1795; pfam08786
1282356013190	PAAR motif; Region: PAAR_motif; pfam05488
1282356013191	RHS Repeat; Region: RHS_repeat; cl11982
1282356013192	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
1282356013193	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
1282356013194	RHS Repeat; Region: RHS_repeat; pfam05593
1282356013195	RHS Repeat; Region: RHS_repeat; pfam05593
1282356013196	RHS Repeat; Region: RHS_repeat; pfam05593
1282356013197	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
1282356013198	RHS protein; Region: RHS; pfam03527
1282356013199	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
1282356013200	RES domain; Region: RES; smart00953
1282356013201	PAAR motif; Region: PAAR_motif; pfam05488
1282356013202	RHS Repeat; Region: RHS_repeat; cl11982
1282356013203	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
1282356013204	RHS Repeat; Region: RHS_repeat; pfam05593
1282356013205	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
1282356013206	RHS Repeat; Region: RHS_repeat; pfam05593
1282356013207	RHS Repeat; Region: RHS_repeat; pfam05593
1282356013208	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
1282356013209	RHS Repeat; Region: RHS_repeat; pfam05593
1282356013210	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
1282356013211	RHS Repeat; Region: RHS_repeat; pfam05593
1282356013212	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
1282356013213	RHS protein; Region: RHS; pfam03527
1282356013214	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
1282356013215	A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414
1282356013216	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
1282356013217	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
1282356013218	RHS protein; Region: RHS; pfam03527
1282356013219	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
1282356013220	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
1282356013221	RHS Repeat; Region: RHS_repeat; pfam05593
1282356013222	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
1282356013223	RHS protein; Region: RHS; pfam03527
1282356013224	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
1282356013225	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
1282356013226	RHS protein; Region: RHS; pfam03527
1282356013227	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
1282356013228	Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040
1282356013229	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1282356013230	IHF dimer interface [polypeptide binding]; other site
1282356013231	IHF - DNA interface [nucleotide binding]; other site
1282356013232	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
1282356013233	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
1282356013234	Rubredoxin [Energy production and conversion]; Region: COG1773
1282356013235	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
1282356013236	iron binding site [ion binding]; other site
1282356013237	Chorismate lyase; Region: Chor_lyase; cl01230
1282356013238	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
1282356013239	UbiA prenyltransferase family; Region: UbiA; pfam01040
1282356013240	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
1282356013241	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
1282356013242	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
1282356013243	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356013244	active site
1282356013245	phosphorylation site [posttranslational modification]
1282356013246	intermolecular recognition site; other site
1282356013247	dimerization interface [polypeptide binding]; other site
1282356013248	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1282356013249	DNA binding site [nucleotide binding]
1282356013250	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
1282356013251	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1282356013252	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356013253	putative active site [active]
1282356013254	heme pocket [chemical binding]; other site
1282356013255	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356013256	dimer interface [polypeptide binding]; other site
1282356013257	phosphorylation site [posttranslational modification]
1282356013258	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356013259	ATP binding site [chemical binding]; other site
1282356013260	Mg2+ binding site [ion binding]; other site
1282356013261	G-X-G motif; other site
1282356013262	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1282356013263	Domain of unknown function DUF21; Region: DUF21; pfam01595
1282356013264	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1282356013265	Transporter associated domain; Region: CorC_HlyC; smart01091
1282356013266	Response regulator receiver domain; Region: Response_reg; pfam00072
1282356013267	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356013268	active site
1282356013269	phosphorylation site [posttranslational modification]
1282356013270	intermolecular recognition site; other site
1282356013271	dimerization interface [polypeptide binding]; other site
1282356013272	transcriptional regulator PhoU; Provisional; Region: PRK11115
1282356013273	PhoU domain; Region: PhoU; pfam01895
1282356013274	PhoU domain; Region: PhoU; pfam01895
1282356013275	phosphate transporter ATP-binding protein; Provisional; Region: PRK14236
1282356013276	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1282356013277	Walker A/P-loop; other site
1282356013278	ATP binding site [chemical binding]; other site
1282356013279	Q-loop/lid; other site
1282356013280	ABC transporter signature motif; other site
1282356013281	Walker B; other site
1282356013282	D-loop; other site
1282356013283	H-loop/switch region; other site
1282356013284	ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985
1282356013285	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
1282356013286	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356013287	dimer interface [polypeptide binding]; other site
1282356013288	conserved gate region; other site
1282356013289	putative PBP binding loops; other site
1282356013290	ABC-ATPase subunit interface; other site
1282356013291	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590
1282356013292	The Sema domain, a protein interacting module, of semaphorins and plexins; Region: Sema; cl15693
1282356013293	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356013294	dimer interface [polypeptide binding]; other site
1282356013295	conserved gate region; other site
1282356013296	putative PBP binding loops; other site
1282356013297	ABC-ATPase subunit interface; other site
1282356013298	PBP superfamily domain; Region: PBP_like_2; cl17296
1282356013299	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356013300	metabolite-proton symporter; Region: 2A0106; TIGR00883
1282356013301	putative substrate translocation pore; other site
1282356013302	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1282356013303	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
1282356013304	active site
1282356013305	phosphate binding residues; other site
1282356013306	catalytic residues [active]
1282356013307	Protein of unknown function (DUF3299); Region: DUF3299; pfam11736
1282356013308	Predicted membrane protein [Function unknown]; Region: COG2261
1282356013309	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1282356013310	ATP-grasp domain; Region: ATP-grasp; pfam02222
1282356013311	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
1282356013312	HipA-like N-terminal domain; Region: HipA_N; pfam07805
1282356013313	cell density-dependent motility repressor; Provisional; Region: PRK10082
1282356013314	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356013315	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1282356013316	dimerization interface [polypeptide binding]; other site
1282356013317	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
1282356013318	Aspartase; Region: Aspartase; cd01357
1282356013319	active sites [active]
1282356013320	tetramer interface [polypeptide binding]; other site
1282356013321	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1282356013322	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
1282356013323	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
1282356013324	active site
1282356013325	homodimer interface [polypeptide binding]; other site
1282356013326	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1282356013327	DNA-binding site [nucleotide binding]; DNA binding site
1282356013328	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1282356013329	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1282356013330	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356013331	homodimer interface [polypeptide binding]; other site
1282356013332	catalytic residue [active]
1282356013333	Putative FMN-binding domain; Region: FMN_bind_2; pfam04299
1282356013334	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1282356013335	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1282356013336	Coenzyme A binding pocket [chemical binding]; other site
1282356013337	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1282356013338	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1282356013339	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1282356013340	Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040
1282356013341	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
1282356013342	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1282356013343	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1282356013344	substrate binding pocket [chemical binding]; other site
1282356013345	membrane-bound complex binding site; other site
1282356013346	hinge residues; other site
1282356013347	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1282356013348	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356013349	dimer interface [polypeptide binding]; other site
1282356013350	conserved gate region; other site
1282356013351	putative PBP binding loops; other site
1282356013352	ABC-ATPase subunit interface; other site
1282356013353	Autotransporter beta-domain; Region: Autotransporter; pfam03797
1282356013354	pyruvate carboxylase subunit B; Validated; Region: PRK09282
1282356013355	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1282356013356	active site
1282356013357	catalytic residues [active]
1282356013358	metal binding site [ion binding]; metal-binding site
1282356013359	homodimer binding site [polypeptide binding]; other site
1282356013360	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1282356013361	carboxyltransferase (CT) interaction site; other site
1282356013362	biotinylation site [posttranslational modification]; other site
1282356013363	pyruvate carboxylase subunit A; Validated; Region: PRK07178
1282356013364	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1282356013365	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1282356013366	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1282356013367	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356013368	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356013369	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
1282356013370	putative dimerization interface [polypeptide binding]; other site
1282356013371	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
1282356013372	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1282356013373	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1282356013374	putative active site [active]
1282356013375	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356013376	PAS fold; Region: PAS_3; pfam08447
1282356013377	putative active site [active]
1282356013378	heme pocket [chemical binding]; other site
1282356013379	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356013380	PAS domain; Region: PAS_9; pfam13426
1282356013381	putative active site [active]
1282356013382	heme pocket [chemical binding]; other site
1282356013383	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1282356013384	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1282356013385	metal binding site [ion binding]; metal-binding site
1282356013386	active site
1282356013387	I-site; other site
1282356013388	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1282356013389	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
1282356013390	Part of AAA domain; Region: AAA_19; pfam13245
1282356013391	Family description; Region: UvrD_C_2; pfam13538
1282356013392	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395
1282356013393	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
1282356013394	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1282356013395	MULE transposase domain; Region: MULE; pfam10551
1282356013396	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1282356013397	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1282356013398	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1282356013399	pyridoxamine kinase; Validated; Region: PRK05756
1282356013400	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
1282356013401	pyridoxal binding site [chemical binding]; other site
1282356013402	dimer interface [polypeptide binding]; other site
1282356013403	ATP binding site [chemical binding]; other site
1282356013404	Protein of unknown function (DUF3301); Region: DUF3301; pfam11743
1282356013405	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1282356013406	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1282356013407	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1282356013408	Protein of unknown function (DUF1826); Region: DUF1826; pfam08856
1282356013409	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1282356013410	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1282356013411	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1282356013412	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
1282356013413	AMIN domain; Region: AMIN; pfam11741
1282356013414	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1282356013415	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1282356013416	active site
1282356013417	metal binding site [ion binding]; metal-binding site
1282356013418	putative GTP cyclohydrolase; Provisional; Region: PRK13674
1282356013419	ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559
1282356013420	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1282356013421	Walker A/P-loop; other site
1282356013422	ATP binding site [chemical binding]; other site
1282356013423	Q-loop/lid; other site
1282356013424	ABC transporter signature motif; other site
1282356013425	Walker B; other site
1282356013426	D-loop; other site
1282356013427	H-loop/switch region; other site
1282356013428	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1282356013429	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1282356013430	ABC-ATPase subunit  interface; other site
1282356013431	dimer interface [polypeptide binding]; other site
1282356013432	putative PBP binding regions; other site
1282356013433	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1282356013434	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
1282356013435	metal binding site [ion binding]; metal-binding site
1282356013436	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1282356013437	Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710
1282356013438	trimer interface [polypeptide binding]; other site
1282356013439	active site
1282356013440	dihydroorotase; Reviewed; Region: PRK09236
1282356013441	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1282356013442	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
1282356013443	active site
1282356013444	Protein of unknown function (DUF3617); Region: DUF3617; pfam12276
1282356013445	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
1282356013446	Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155
1282356013447	putative active site [active]
1282356013448	catalytic site [active]
1282356013449	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1282356013450	putative active site [active]
1282356013451	catalytic site [active]
1282356013452	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
1282356013453	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356013454	S-adenosylmethionine binding site [chemical binding]; other site
1282356013455	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
1282356013456	hypothetical protein; Provisional; Region: PRK05409
1282356013457	Predicted integral membrane protein (DUF2282); Region: DUF2282; cl02366
1282356013458	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
1282356013459	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1282356013460	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
1282356013461	HflK protein; Region: hflK; TIGR01933
1282356013462	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
1282356013463	HflC protein; Region: hflC; TIGR01932
1282356013464	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1282356013465	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
1282356013466	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
1282356013467	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1282356013468	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1282356013469	Putative methyltransferase; Region: Methyltransf_20; pfam12147
1282356013470	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
1282356013471	active site
1282356013472	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
1282356013473	active site
1282356013474	catalytic residues [active]
1282356013475	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1282356013476	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1282356013477	putative acyl-acceptor binding pocket; other site
1282356013478	Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589
1282356013479	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1282356013480	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1282356013481	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1282356013482	Coenzyme A binding pocket [chemical binding]; other site
1282356013483	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1282356013484	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1282356013485	glutaminase active site [active]
1282356013486	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1282356013487	dimer interface [polypeptide binding]; other site
1282356013488	active site
1282356013489	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1282356013490	dimer interface [polypeptide binding]; other site
1282356013491	active site
1282356013492	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1282356013493	putative DNA binding site [nucleotide binding]; other site
1282356013494	DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434
1282356013495	putative Zn2+ binding site [ion binding]; other site
1282356013496	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1282356013497	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
1282356013498	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1282356013499	Substrate binding site; other site
1282356013500	Mg++ binding site; other site
1282356013501	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1282356013502	active site
1282356013503	substrate binding site [chemical binding]; other site
1282356013504	CoA binding site [chemical binding]; other site
1282356013505	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
1282356013506	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1282356013507	gamma subunit interface [polypeptide binding]; other site
1282356013508	epsilon subunit interface [polypeptide binding]; other site
1282356013509	LBP interface [polypeptide binding]; other site
1282356013510	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1282356013511	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1282356013512	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1282356013513	alpha subunit interaction interface [polypeptide binding]; other site
1282356013514	Walker A motif; other site
1282356013515	ATP binding site [chemical binding]; other site
1282356013516	Walker B motif; other site
1282356013517	inhibitor binding site; inhibition site
1282356013518	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1282356013519	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1282356013520	core domain interface [polypeptide binding]; other site
1282356013521	delta subunit interface [polypeptide binding]; other site
1282356013522	epsilon subunit interface [polypeptide binding]; other site
1282356013523	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1282356013524	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1282356013525	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1282356013526	beta subunit interaction interface [polypeptide binding]; other site
1282356013527	Walker A motif; other site
1282356013528	ATP binding site [chemical binding]; other site
1282356013529	Walker B motif; other site
1282356013530	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1282356013531	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
1282356013532	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1282356013533	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1282356013534	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
1282356013535	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
1282356013536	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1282356013537	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1282356013538	F0F1 ATP synthase subunit I; Validated; Region: PRK05760
1282356013539	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1282356013540	ParB-like nuclease domain; Region: ParBc; pfam02195
1282356013541	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1282356013542	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1282356013543	P-loop; other site
1282356013544	Magnesium ion binding site [ion binding]; other site
1282356013545	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1282356013546	Magnesium ion binding site [ion binding]; other site
1282356013547	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
1282356013548	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356013549	S-adenosylmethionine binding site [chemical binding]; other site
1282356013550	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
1282356013551	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
1282356013552	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
1282356013553	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1282356013554	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
1282356013555	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1282356013556	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1282356013557	G1 box; other site
1282356013558	GTP/Mg2+ binding site [chemical binding]; other site
1282356013559	Switch I region; other site
1282356013560	G2 box; other site
1282356013561	Switch II region; other site
1282356013562	G3 box; other site
1282356013563	G4 box; other site
1282356013564	G5 box; other site
1282356013565	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1282356013566	membrane protein insertase; Provisional; Region: PRK01318
1282356013567	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
1282356013568	hypothetical protein; Provisional; Region: PRK14371
1282356013569	ribonuclease P; Reviewed; Region: rnpA; PRK00396
1282356013570	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
1282356013571	DnaA N-terminal domain; Region: DnaA_N; pfam11638
1282356013572	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
1282356013573	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356013574	Walker A motif; other site
1282356013575	ATP binding site [chemical binding]; other site
1282356013576	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1282356013577	Walker B motif; other site
1282356013578	arginine finger; other site
1282356013579	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1282356013580	DnaA box-binding interface [nucleotide binding]; other site
1282356013581	DNA polymerase III subunit beta; Validated; Region: PRK05643
1282356013582	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1282356013583	putative DNA binding surface [nucleotide binding]; other site
1282356013584	dimer interface [polypeptide binding]; other site
1282356013585	beta-clamp/clamp loader binding surface; other site
1282356013586	beta-clamp/translesion DNA polymerase binding surface; other site
1282356013587	recombination protein F; Reviewed; Region: recF; PRK00064
1282356013588	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1282356013589	Walker A/P-loop; other site
1282356013590	ATP binding site [chemical binding]; other site
1282356013591	Q-loop/lid; other site
1282356013592	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1282356013593	ABC transporter signature motif; other site
1282356013594	Walker B; other site
1282356013595	D-loop; other site
1282356013596	H-loop/switch region; other site
1282356013597	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
1282356013598	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356013599	Mg2+ binding site [ion binding]; other site
1282356013600	G-X-G motif; other site
1282356013601	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1282356013602	anchoring element; other site
1282356013603	dimer interface [polypeptide binding]; other site
1282356013604	ATP binding site [chemical binding]; other site
1282356013605	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1282356013606	active site
1282356013607	putative metal-binding site [ion binding]; other site
1282356013608	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1282356013609	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
1282356013610	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1282356013611	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1282356013612	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1282356013613	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1282356013614	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1282356013615	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
1282356013616	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
1282356013617	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1282356013618	ATP binding site [chemical binding]; other site
1282356013619	putative Mg++ binding site [ion binding]; other site
1282356013620	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1282356013621	catalytic residues [active]
1282356013622	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356013623	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1282356013624	Walker A motif; other site
1282356013625	ATP binding site [chemical binding]; other site
1282356013626	Walker B motif; other site
1282356013627	arginine finger; other site
1282356013628	Integrase core domain; Region: rve; pfam00665
1282356013629	AAA domain; Region: AAA_22; pfam13401
1282356013630	TniQ; Region: TniQ; pfam06527
1282356013631	ParB-like nuclease domain; Region: ParB; smart00470
1282356013632	RepB plasmid partitioning protein; Region: RepB; pfam07506
1282356013633	ParB-like nuclease domain; Region: ParB; smart00470
1282356013634	RepB plasmid partitioning protein; Region: RepB; pfam07506
1282356013635	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1282356013636	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1282356013637	catalytic residues [active]
1282356013638	Recombinase; Region: Recombinase; pfam07508
1282356013639	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1282356013640	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356013641	active site
1282356013642	phosphorylation site [posttranslational modification]
1282356013643	intermolecular recognition site; other site
1282356013644	dimerization interface [polypeptide binding]; other site
1282356013645	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1282356013646	DNA binding site [nucleotide binding]
1282356013647	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1282356013648	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356013649	dimer interface [polypeptide binding]; other site
1282356013650	phosphorylation site [posttranslational modification]
1282356013651	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356013652	ATP binding site [chemical binding]; other site
1282356013653	Mg2+ binding site [ion binding]; other site
1282356013654	G-X-G motif; other site
1282356013655	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1282356013656	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1282356013657	putative acyl-acceptor binding pocket; other site
1282356013658	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
1282356013659	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1282356013660	active site
1282356013661	motif I; other site
1282356013662	motif II; other site
1282356013663	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
1282356013664	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
1282356013665	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1282356013666	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
1282356013667	dimer interface [polypeptide binding]; other site
1282356013668	motif 1; other site
1282356013669	active site
1282356013670	motif 2; other site
1282356013671	motif 3; other site
1282356013672	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1282356013673	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1282356013674	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
1282356013675	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1282356013676	putative acyl-acceptor binding pocket; other site
1282356013677	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1282356013678	TPR motif; other site
1282356013679	binding surface
1282356013680	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
1282356013681	TrkA-N domain; Region: TrkA_N; pfam02254
1282356013682	TrkA-C domain; Region: TrkA_C; pfam02080
1282356013683	TrkA-N domain; Region: TrkA_N; pfam02254
1282356013684	TrkA-C domain; Region: TrkA_C; pfam02080
1282356013685	16S rRNA methyltransferase B; Provisional; Region: PRK10901
1282356013686	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
1282356013687	putative RNA binding site [nucleotide binding]; other site
1282356013688	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356013689	S-adenosylmethionine binding site [chemical binding]; other site
1282356013690	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1282356013691	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1282356013692	putative active site [active]
1282356013693	substrate binding site [chemical binding]; other site
1282356013694	putative cosubstrate binding site; other site
1282356013695	catalytic site [active]
1282356013696	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1282356013697	substrate binding site [chemical binding]; other site
1282356013698	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1282356013699	active site
1282356013700	catalytic residues [active]
1282356013701	metal binding site [ion binding]; metal-binding site
1282356013702	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
1282356013703	DNA protecting protein DprA; Region: dprA; TIGR00732
1282356013704	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1282356013705	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
1282356013706	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
1282356013707	NADP binding site [chemical binding]; other site
1282356013708	dimer interface [polypeptide binding]; other site
1282356013709	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
1282356013710	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
1282356013711	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
1282356013712	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1282356013713	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1282356013714	NAD(P) binding site [chemical binding]; other site
1282356013715	shikimate binding site; other site
1282356013716	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1282356013717	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1282356013718	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1282356013719	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1282356013720	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1282356013721	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
1282356013722	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
1282356013723	Sulfatase; Region: Sulfatase; cl17466
1282356013724	choline-sulfatase; Region: chol_sulfatase; TIGR03417
1282356013725	Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411
1282356013726	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
1282356013727	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356013728	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1282356013729	dimerization interface [polypeptide binding]; other site
1282356013730	Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883
1282356013731	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
1282356013732	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
1282356013733	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
1282356013734	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1282356013735	active site
1282356013736	intersubunit interface [polypeptide binding]; other site
1282356013737	catalytic residue [active]
1282356013738	galactonate dehydratase; Provisional; Region: PRK14017
1282356013739	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
1282356013740	putative active site pocket [active]
1282356013741	putative metal binding site [ion binding]; other site
1282356013742	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356013743	D-galactonate transporter; Region: 2A0114; TIGR00893
1282356013744	putative substrate translocation pore; other site
1282356013745	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
1282356013746	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1282356013747	substrate binding site [chemical binding]; other site
1282356013748	active site
1282356013749	catalytic residues [active]
1282356013750	heterodimer interface [polypeptide binding]; other site
1282356013751	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1282356013752	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1282356013753	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356013754	catalytic residue [active]
1282356013755	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1282356013756	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356013757	The C-terminal substrate binding domain of LysR-type transcriptional regulator TrpI, which is involved in control of tryptophan synthesis, contains type 2 periplasmic binding fold; Region: PBP2_TrpI; cd08482
1282356013758	putative dimerization interface [polypeptide binding]; other site
1282356013759	putative substrate binding pocket [chemical binding]; other site
1282356013760	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
1282356013761	Dodecin; Region: Dodecin; pfam07311
1282356013762	Protein of unknown function (DUF1161); Region: DUF1161; pfam06649
1282356013763	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1282356013764	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1282356013765	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
1282356013766	Protein of unknown function (DUF1161); Region: DUF1161; pfam06649
1282356013767	Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023
1282356013768	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1282356013769	Eukaryotic phosphomannomutase; Region: PMM; cl17107
1282356013770	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1282356013771	motif II; other site
1282356013772	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1282356013773	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
1282356013774	trimer interface [polypeptide binding]; other site
1282356013775	putative metal binding site [ion binding]; other site
1282356013776	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
1282356013777	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
1282356013778	active site
1282356013779	Zn binding site [ion binding]; other site
1282356013780	Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526
1282356013781	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
1282356013782	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1282356013783	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1282356013784	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1282356013785	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1282356013786	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1282356013787	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
1282356013788	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
1282356013789	FeS/SAM binding site; other site
1282356013790	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
1282356013791	active site clefts [active]
1282356013792	zinc binding site [ion binding]; other site
1282356013793	dimer interface [polypeptide binding]; other site
1282356013794	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1282356013795	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1282356013796	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1282356013797	MULE transposase domain; Region: MULE; pfam10551
1282356013798	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
1282356013799	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
1282356013800	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
1282356013801	Cu(I) binding site [ion binding]; other site
1282356013802	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1282356013803	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1282356013804	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356013805	dimer interface [polypeptide binding]; other site
1282356013806	conserved gate region; other site
1282356013807	ABC-ATPase subunit interface; other site
1282356013808	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
1282356013809	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1282356013810	Walker A/P-loop; other site
1282356013811	ATP binding site [chemical binding]; other site
1282356013812	Q-loop/lid; other site
1282356013813	ABC transporter signature motif; other site
1282356013814	Walker B; other site
1282356013815	D-loop; other site
1282356013816	H-loop/switch region; other site
1282356013817	NIL domain; Region: NIL; pfam09383
1282356013818	hydroperoxidase II; Provisional; Region: katE; PRK11249
1282356013819	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
1282356013820	tetramer interface [polypeptide binding]; other site
1282356013821	heme binding pocket [chemical binding]; other site
1282356013822	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
1282356013823	domain interactions; other site
1282356013824	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1282356013825	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1282356013826	ABC-ATPase subunit  interface; other site
1282356013827	dimer interface [polypeptide binding]; other site
1282356013828	putative PBP binding regions; other site
1282356013829	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
1282356013830	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1282356013831	Walker A/P-loop; other site
1282356013832	ATP binding site [chemical binding]; other site
1282356013833	Q-loop/lid; other site
1282356013834	ABC transporter signature motif; other site
1282356013835	Walker B; other site
1282356013836	D-loop; other site
1282356013837	H-loop/switch region; other site
1282356013838	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1282356013839	metal binding site 2 [ion binding]; metal-binding site
1282356013840	putative DNA binding helix; other site
1282356013841	metal binding site 1 [ion binding]; metal-binding site
1282356013842	dimer interface [polypeptide binding]; other site
1282356013843	structural Zn2+ binding site [ion binding]; other site
1282356013844	ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531
1282356013845	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
1282356013846	metal binding site [ion binding]; metal-binding site
1282356013847	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
1282356013848	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
1282356013849	putative active site [active]
1282356013850	putative substrate binding site [chemical binding]; other site
1282356013851	ATP binding site [chemical binding]; other site
1282356013852	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
1282356013853	DNA polymerase I; Provisional; Region: PRK05755
1282356013854	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1282356013855	active site
1282356013856	metal binding site 1 [ion binding]; metal-binding site
1282356013857	putative 5' ssDNA interaction site; other site
1282356013858	metal binding site 3; metal-binding site
1282356013859	metal binding site 2 [ion binding]; metal-binding site
1282356013860	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1282356013861	putative DNA binding site [nucleotide binding]; other site
1282356013862	putative metal binding site [ion binding]; other site
1282356013863	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
1282356013864	active site
1282356013865	catalytic site [active]
1282356013866	substrate binding site [chemical binding]; other site
1282356013867	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1282356013868	active site
1282356013869	DNA binding site [nucleotide binding]
1282356013870	catalytic site [active]
1282356013871	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1282356013872	G1 box; other site
1282356013873	GTP/Mg2+ binding site [chemical binding]; other site
1282356013874	Switch I region; other site
1282356013875	G2 box; other site
1282356013876	G3 box; other site
1282356013877	Switch II region; other site
1282356013878	G4 box; other site
1282356013879	G5 box; other site
1282356013880	Cytochrome c553 [Energy production and conversion]; Region: COG2863
1282356013881	Cytochrome c; Region: Cytochrom_C; cl11414
1282356013882	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
1282356013883	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1282356013884	catalytic residues [active]
1282356013885	hinge region; other site
1282356013886	alpha helical domain; other site
1282356013887	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1282356013888	putative catalytic site [active]
1282356013889	putative metal binding site [ion binding]; other site
1282356013890	putative phosphate binding site [ion binding]; other site
1282356013891	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1282356013892	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1282356013893	metal binding site [ion binding]; metal-binding site
1282356013894	active site
1282356013895	I-site; other site
1282356013896	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
1282356013897	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1282356013898	amidase catalytic site [active]
1282356013899	Zn binding residues [ion binding]; other site
1282356013900	substrate binding site [chemical binding]; other site
1282356013901	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1282356013902	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1282356013903	dimerization interface [polypeptide binding]; other site
1282356013904	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1282356013905	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356013906	putative active site [active]
1282356013907	heme pocket [chemical binding]; other site
1282356013908	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356013909	dimer interface [polypeptide binding]; other site
1282356013910	phosphorylation site [posttranslational modification]
1282356013911	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356013912	ATP binding site [chemical binding]; other site
1282356013913	Mg2+ binding site [ion binding]; other site
1282356013914	G-X-G motif; other site
1282356013915	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1282356013916	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356013917	active site
1282356013918	phosphorylation site [posttranslational modification]
1282356013919	intermolecular recognition site; other site
1282356013920	dimerization interface [polypeptide binding]; other site
1282356013921	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356013922	Walker A motif; other site
1282356013923	ATP binding site [chemical binding]; other site
1282356013924	Walker B motif; other site
1282356013925	arginine finger; other site
1282356013926	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1282356013927	Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816
1282356013928	glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283
1282356013929	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1282356013930	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
1282356013931	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
1282356013932	Protein of unknown function (DUF2914); Region: DUF2914; pfam11141
1282356013933	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1282356013934	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1282356013935	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1282356013936	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
1282356013937	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1282356013938	PhoU domain; Region: PhoU; pfam01895
1282356013939	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
1282356013940	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
1282356013941	Citrate transporter; Region: CitMHS; pfam03600
1282356013942	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
1282356013943	Protein of unknown function (DUF2388); Region: DUF2388; pfam09498
1282356013944	conserverd hypothetical protein; Region: TIGR02448
1282356013945	Protein of unknown function (DUF2388); Region: DUF2388; pfam09498
1282356013946	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
1282356013947	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
1282356013948	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
1282356013949	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
1282356013950	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
1282356013951	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
1282356013952	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
1282356013953	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
1282356013954	ligand binding site [chemical binding]; other site
1282356013955	homodimer interface [polypeptide binding]; other site
1282356013956	NAD(P) binding site [chemical binding]; other site
1282356013957	trimer interface B [polypeptide binding]; other site
1282356013958	trimer interface A [polypeptide binding]; other site
1282356013959	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1282356013960	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356013961	The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481
1282356013962	dimerization interface [polypeptide binding]; other site
1282356013963	substrate binding pocket [chemical binding]; other site
1282356013964	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
1282356013965	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1282356013966	FAD binding site [chemical binding]; other site
1282356013967	substrate binding pocket [chemical binding]; other site
1282356013968	catalytic base [active]
1282356013969	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1282356013970	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1282356013971	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
1282356013972	Cache domain; Region: Cache_1; pfam02743
1282356013973	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1282356013974	dimerization interface [polypeptide binding]; other site
1282356013975	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1282356013976	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356013977	dimer interface [polypeptide binding]; other site
1282356013978	putative CheW interface [polypeptide binding]; other site
1282356013979	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
1282356013980	gate; other site
1282356013981	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1282356013982	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1282356013983	acyl-activating enzyme (AAE) consensus motif; other site
1282356013984	AMP binding site [chemical binding]; other site
1282356013985	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1282356013986	thioester reductase domain; Region: Thioester-redct; TIGR01746
1282356013987	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
1282356013988	putative NAD(P) binding site [chemical binding]; other site
1282356013989	active site
1282356013990	putative substrate binding site [chemical binding]; other site
1282356013991	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
1282356013992	Protein of unknown function (DUF3050); Region: DUF3050; pfam11251
1282356013993	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1282356013994	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1282356013995	DNA-binding site [nucleotide binding]; DNA binding site
1282356013996	FCD domain; Region: FCD; pfam07729
1282356013997	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
1282356013998	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
1282356013999	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1282356014000	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1282356014001	Walker A/P-loop; other site
1282356014002	ATP binding site [chemical binding]; other site
1282356014003	Q-loop/lid; other site
1282356014004	ABC transporter signature motif; other site
1282356014005	Walker B; other site
1282356014006	D-loop; other site
1282356014007	H-loop/switch region; other site
1282356014008	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1282356014009	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356014010	dimer interface [polypeptide binding]; other site
1282356014011	conserved gate region; other site
1282356014012	putative PBP binding loops; other site
1282356014013	ABC-ATPase subunit interface; other site
1282356014014	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356014015	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356014016	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
1282356014017	putative substrate binding pocket [chemical binding]; other site
1282356014018	putative dimerization interface [polypeptide binding]; other site
1282356014019	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1282356014020	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356014021	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1282356014022	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1282356014023	HlyD family secretion protein; Region: HlyD_3; pfam13437
1282356014024	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1282356014025	Protein of unknown function (DUF3142); Region: DUF3142; pfam11340
1282356014026	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
1282356014027	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1282356014028	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1282356014029	Fusaric acid resistance protein family; Region: FUSC; pfam04632
1282356014030	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1282356014031	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
1282356014032	p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559
1282356014033	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1282356014034	HlyD family secretion protein; Region: HlyD_3; pfam13437
1282356014035	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1282356014036	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
1282356014037	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
1282356014038	outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049
1282356014039	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1282356014040	TPR motif; other site
1282356014041	binding surface
1282356014042	outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582
1282356014043	N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964
1282356014044	putative active site [active]
1282356014045	putative metal binding site [ion binding]; other site
1282356014046	N-glycosyltransferase; Provisional; Region: PRK11204
1282356014047	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1282356014048	DXD motif; other site
1282356014049	PgaD-like protein; Region: PgaD; pfam13994
1282356014050	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
1282356014051	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
1282356014052	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
1282356014053	haemagglutination activity domain; Region: Haemagg_act; pfam05860
1282356014054	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
1282356014055	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1282356014056	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1282356014057	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1282356014058	Possible hemagglutinin (DUF637); Region: DUF637; pfam04830
1282356014059	potential frameshift: common BLAST hit: gi|387891406|ref|YP_006321703.1| adhesin/hemagglutinin, HecA family
1282356014060	HEAT repeats; Region: HEAT_2; pfam13646
1282356014061	Transposase domain (DUF772); Region: DUF772; pfam05598
1282356014062	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
1282356014063	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1282356014064	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1282356014065	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1282356014066	insertion element IS2 transposase InsD; Provisional; Region: PRK14702
1282356014067	HTH-like domain; Region: HTH_21; pfam13276
1282356014068	Integrase core domain; Region: rve; pfam00665
1282356014069	Integrase core domain; Region: rve_3; pfam13683
1282356014070	Transposase; Region: HTH_Tnp_1; cl17663
1282356014071	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1282356014072	Possible hemagglutinin (DUF637); Region: DUF637; pfam04830
1282356014073	Transposase; Region: HTH_Tnp_1; cl17663
1282356014074	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1282356014075	insertion element IS2 transposase InsD; Provisional; Region: PRK14702
1282356014076	HTH-like domain; Region: HTH_21; pfam13276
1282356014077	Integrase core domain; Region: rve; pfam00665
1282356014078	Integrase core domain; Region: rve_3; pfam13683
1282356014079	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1282356014080	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1282356014081	haemagglutination activity domain; Region: Haemagg_act; pfam05860
1282356014082	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
1282356014083	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1282356014084	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1282356014085	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1282356014086	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1282356014087	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1282356014088	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1282356014089	Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462
1282356014090	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259
1282356014091	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4380
1282356014092	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1282356014093	RNA polymerase sigma factor; Provisional; Region: PRK12513
1282356014094	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1282356014095	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1282356014096	DNA binding residues [nucleotide binding]
1282356014097	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1282356014098	MULE transposase domain; Region: MULE; pfam10551
1282356014099	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
1282356014100	succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241
1282356014101	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1282356014102	tetramerization interface [polypeptide binding]; other site
1282356014103	NAD(P) binding site [chemical binding]; other site
1282356014104	catalytic residues [active]
1282356014105	4-aminobutyrate aminotransferase; Validated; Region: PRK08088
1282356014106	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1282356014107	inhibitor-cofactor binding pocket; inhibition site
1282356014108	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356014109	catalytic residue [active]
1282356014110	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356014111	PAS fold; Region: PAS_3; pfam08447
1282356014112	putative active site [active]
1282356014113	heme pocket [chemical binding]; other site
1282356014114	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
1282356014115	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1282356014116	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1282356014117	metal binding site [ion binding]; metal-binding site
1282356014118	active site
1282356014119	I-site; other site
1282356014120	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1282356014121	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
1282356014122	Di-iron ligands [ion binding]; other site
1282356014123	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
1282356014124	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1282356014125	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356014126	PAS domain; Region: PAS_9; pfam13426
1282356014127	putative active site [active]
1282356014128	heme pocket [chemical binding]; other site
1282356014129	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1282356014130	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1282356014131	metal binding site [ion binding]; metal-binding site
1282356014132	active site
1282356014133	I-site; other site
1282356014134	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1282356014135	Uncharacterized small protein [Function unknown]; Region: COG5583
1282356014136	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
1282356014137	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1282356014138	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1282356014139	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356014140	dimer interface [polypeptide binding]; other site
1282356014141	conserved gate region; other site
1282356014142	putative PBP binding loops; other site
1282356014143	ABC-ATPase subunit interface; other site
1282356014144	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1282356014145	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356014146	dimer interface [polypeptide binding]; other site
1282356014147	conserved gate region; other site
1282356014148	putative PBP binding loops; other site
1282356014149	ABC-ATPase subunit interface; other site
1282356014150	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
1282356014151	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
1282356014152	Walker A/P-loop; other site
1282356014153	ATP binding site [chemical binding]; other site
1282356014154	Q-loop/lid; other site
1282356014155	ABC transporter signature motif; other site
1282356014156	Walker B; other site
1282356014157	D-loop; other site
1282356014158	H-loop/switch region; other site
1282356014159	TOBE-like domain; Region: TOBE_3; pfam12857
1282356014160	Predicted membrane protein [Function unknown]; Region: COG4539
1282356014161	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1282356014162	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1282356014163	ligand binding site [chemical binding]; other site
1282356014164	flexible hinge region; other site
1282356014165	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1282356014166	putative switch regulator; other site
1282356014167	non-specific DNA interactions [nucleotide binding]; other site
1282356014168	DNA binding site [nucleotide binding]
1282356014169	sequence specific DNA binding site [nucleotide binding]; other site
1282356014170	putative cAMP binding site [chemical binding]; other site
1282356014171	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
1282356014172	active site
1282356014173	homotetramer interface [polypeptide binding]; other site
1282356014174	Response regulator receiver domain; Region: Response_reg; pfam00072
1282356014175	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356014176	active site
1282356014177	phosphorylation site [posttranslational modification]
1282356014178	intermolecular recognition site; other site
1282356014179	dimerization interface [polypeptide binding]; other site
1282356014180	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1282356014181	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1282356014182	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1282356014183	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1282356014184	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
1282356014185	putative di-iron ligands [ion binding]; other site
1282356014186	cyanate transporter; Region: CynX; TIGR00896
1282356014187	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356014188	Serine hydrolase; Region: Ser_hydrolase; pfam06821
1282356014189	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1282356014190	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356014191	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1282356014192	Walker A motif; other site
1282356014193	ATP binding site [chemical binding]; other site
1282356014194	Walker B motif; other site
1282356014195	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1282356014196	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1282356014197	Predicted ATPase [General function prediction only]; Region: COG4637
1282356014198	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1282356014199	Walker A/P-loop; other site
1282356014200	ATP binding site [chemical binding]; other site
1282356014201	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1282356014202	HlyD family secretion protein; Region: HlyD_3; pfam13437
1282356014203	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1282356014204	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1282356014205	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1282356014206	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1282356014207	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356014208	S-adenosylmethionine binding site [chemical binding]; other site
1282356014209	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356014210	dimer interface [polypeptide binding]; other site
1282356014211	conserved gate region; other site
1282356014212	ABC-ATPase subunit interface; other site
1282356014213	potential frameshift: common BLAST hit: gi|229587803|ref|YP_002869922.1| amino acid ABC transporter ATP-binding protein
1282356014214	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1282356014215	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1282356014216	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1282356014217	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1282356014218	non-prolyl cis peptide bond; other site
1282356014219	active site
1282356014220	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
1282356014221	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1282356014222	active site
1282356014223	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
1282356014224	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1282356014225	active site
1282356014226	putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264
1282356014227	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1282356014228	Walker A/P-loop; other site
1282356014229	ATP binding site [chemical binding]; other site
1282356014230	Q-loop/lid; other site
1282356014231	ABC transporter signature motif; other site
1282356014232	Walker B; other site
1282356014233	D-loop; other site
1282356014234	H-loop/switch region; other site
1282356014235	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356014236	dimer interface [polypeptide binding]; other site
1282356014237	conserved gate region; other site
1282356014238	putative PBP binding loops; other site
1282356014239	ABC-ATPase subunit interface; other site
1282356014240	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1282356014241	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1282356014242	substrate binding pocket [chemical binding]; other site
1282356014243	membrane-bound complex binding site; other site
1282356014244	hinge residues; other site
1282356014245	D-cysteine desulfhydrase; Validated; Region: PRK03910
1282356014246	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
1282356014247	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1282356014248	catalytic residue [active]
1282356014249	serine O-acetyltransferase; Region: cysE; TIGR01172
1282356014250	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1282356014251	trimer interface [polypeptide binding]; other site
1282356014252	active site
1282356014253	substrate binding site [chemical binding]; other site
1282356014254	CoA binding site [chemical binding]; other site
1282356014255	BCCT family transporter; Region: BCCT; cl00569
1282356014256	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1282356014257	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1282356014258	active site
1282356014259	catalytic tetrad [active]
1282356014260	glutamate--cysteine ligase; Provisional; Region: PRK02107
1282356014261	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1282356014262	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1282356014263	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1282356014264	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
1282356014265	RNA binding site [nucleotide binding]; other site
1282356014266	osmolarity response regulator; Provisional; Region: ompR; PRK09468
1282356014267	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356014268	active site
1282356014269	phosphorylation site [posttranslational modification]
1282356014270	intermolecular recognition site; other site
1282356014271	dimerization interface [polypeptide binding]; other site
1282356014272	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1282356014273	DNA binding site [nucleotide binding]
1282356014274	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
1282356014275	HAMP domain; Region: HAMP; pfam00672
1282356014276	dimerization interface [polypeptide binding]; other site
1282356014277	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356014278	ATP binding site [chemical binding]; other site
1282356014279	Mg2+ binding site [ion binding]; other site
1282356014280	G-X-G motif; other site
1282356014281	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
1282356014282	RimK-like ATP-grasp domain; Region: RimK; pfam08443
1282356014283	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
1282356014284	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1282356014285	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1282356014286	RNA binding surface [nucleotide binding]; other site
1282356014287	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
1282356014288	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
1282356014289	dimerization interface [polypeptide binding]; other site
1282356014290	domain crossover interface; other site
1282356014291	redox-dependent activation switch; other site
1282356014292	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
1282356014293	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
1282356014294	active site
1282356014295	substrate-binding site [chemical binding]; other site
1282356014296	metal-binding site [ion binding]
1282356014297	ATP binding site [chemical binding]; other site
1282356014298	Protein of unknown function (DUF1493); Region: DUF1493; pfam07377
1282356014299	Fic/DOC family; Region: Fic; cl00960
1282356014300	Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184
1282356014301	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1282356014302	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1282356014303	ATP binding site [chemical binding]; other site
1282356014304	putative Mg++ binding site [ion binding]; other site
1282356014305	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1282356014306	nucleotide binding region [chemical binding]; other site
1282356014307	ATP-binding site [chemical binding]; other site
1282356014308	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1282356014309	active site
1282356014310	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
1282356014311	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
1282356014312	putative molybdopterin cofactor binding site [chemical binding]; other site
1282356014313	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
1282356014314	putative molybdopterin cofactor binding site; other site
1282356014315	Uncharacterized protein required for formate dehydrogenase activity [Energy production and conversion]; Region: FdhD; COG1526
1282356014316	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356014317	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356014318	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1282356014319	dimerization interface [polypeptide binding]; other site
1282356014320	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
1282356014321	BON domain; Region: BON; pfam04972
1282356014322	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1282356014323	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
1282356014324	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1282356014325	motif II; other site
1282356014326	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
1282356014327	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1282356014328	dimer interface [polypeptide binding]; other site
1282356014329	ADP-ribose binding site [chemical binding]; other site
1282356014330	active site
1282356014331	nudix motif; other site
1282356014332	metal binding site [ion binding]; metal-binding site
1282356014333	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
1282356014334	active site
1282356014335	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500
1282356014336	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1282356014337	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356014338	active site
1282356014339	phosphorylation site [posttranslational modification]
1282356014340	intermolecular recognition site; other site
1282356014341	dimerization interface [polypeptide binding]; other site
1282356014342	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356014343	Walker A motif; other site
1282356014344	ATP binding site [chemical binding]; other site
1282356014345	Walker B motif; other site
1282356014346	arginine finger; other site
1282356014347	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
1282356014348	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356014349	dimer interface [polypeptide binding]; other site
1282356014350	phosphorylation site [posttranslational modification]
1282356014351	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356014352	ATP binding site [chemical binding]; other site
1282356014353	G-X-G motif; other site
1282356014354	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
1282356014355	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1282356014356	NADP binding site [chemical binding]; other site
1282356014357	active site
1282356014358	putative substrate binding site [chemical binding]; other site
1282356014359	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221
1282356014360	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1282356014361	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
1282356014362	substrate binding site; other site
1282356014363	tetramer interface; other site
1282356014364	dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084
1282356014365	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1282356014366	NAD binding site [chemical binding]; other site
1282356014367	substrate binding site [chemical binding]; other site
1282356014368	homodimer interface [polypeptide binding]; other site
1282356014369	active site
1282356014370	agmatine deiminase; Provisional; Region: PRK13551
1282356014371	agmatine deiminase; Region: agmatine_aguA; TIGR03380
1282356014372	outer membrane porin, OprD family; Region: OprD; pfam03573
1282356014373	Peptidase family M48; Region: Peptidase_M48; cl12018
1282356014374	CHASE2 domain; Region: CHASE2; cl01732
1282356014375	Beta protein; Region: Beta_protein; pfam14350
1282356014376	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1282356014377	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1282356014378	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1282356014379	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1282356014380	Integrase; Region: Integrase_1; pfam12835
1282356014381	Integrase core domain; Region: rve; pfam00665
1282356014382	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1282356014383	Transposase; Region: HTH_Tnp_1; cl17663
1282356014384	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1282356014385	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1282356014386	HlyD family secretion protein; Region: HlyD_3; pfam13437
1282356014387	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421
1282356014388	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
1282356014389	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1282356014390	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1282356014391	Walker A/P-loop; other site
1282356014392	ATP binding site [chemical binding]; other site
1282356014393	Q-loop/lid; other site
1282356014394	ABC transporter signature motif; other site
1282356014395	Walker B; other site
1282356014396	D-loop; other site
1282356014397	H-loop/switch region; other site
1282356014398	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
1282356014399	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1282356014400	metal ion-dependent adhesion site (MIDAS); other site
1282356014401	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
1282356014402	biofilm formation regulator HmsP; Provisional; Region: PRK11829
1282356014403	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1282356014404	dimerization interface [polypeptide binding]; other site
1282356014405	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1282356014406	metal binding site [ion binding]; metal-binding site
1282356014407	active site
1282356014408	I-site; other site
1282356014409	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1282356014410	Predicted transglutaminase-like cysteine proteinase [General    function prediction only]; Region: COG3672
1282356014411	cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371
1282356014412	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1282356014413	P-loop; other site
1282356014414	Magnesium ion binding site [ion binding]; other site
1282356014415	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1282356014416	Methyltransferase domain; Region: Methyltransf_32; pfam13679
1282356014417	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1282356014418	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356014419	dimer interface [polypeptide binding]; other site
1282356014420	conserved gate region; other site
1282356014421	putative PBP binding loops; other site
1282356014422	ABC-ATPase subunit interface; other site
1282356014423	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1282356014424	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356014425	dimer interface [polypeptide binding]; other site
1282356014426	conserved gate region; other site
1282356014427	putative PBP binding loops; other site
1282356014428	ABC-ATPase subunit interface; other site
1282356014429	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1282356014430	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1282356014431	substrate binding pocket [chemical binding]; other site
1282356014432	membrane-bound complex binding site; other site
1282356014433	hinge residues; other site
1282356014434	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
1282356014435	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1282356014436	Walker A/P-loop; other site
1282356014437	ATP binding site [chemical binding]; other site
1282356014438	Q-loop/lid; other site
1282356014439	ABC transporter signature motif; other site
1282356014440	Walker B; other site
1282356014441	D-loop; other site
1282356014442	H-loop/switch region; other site
1282356014443	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
1282356014444	Spore germination protein; Region: Spore_permease; cl17796
1282356014445	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
1282356014446	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1282356014447	oxidative damage protection protein; Provisional; Region: PRK05408
1282356014448	adenine DNA glycosylase; Provisional; Region: PRK10880
1282356014449	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1282356014450	minor groove reading motif; other site
1282356014451	helix-hairpin-helix signature motif; other site
1282356014452	substrate binding pocket [chemical binding]; other site
1282356014453	active site
1282356014454	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
1282356014455	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
1282356014456	DNA binding and oxoG recognition site [nucleotide binding]
1282356014457	AsmA family; Region: AsmA; pfam05170
1282356014458	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1282356014459	oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259
1282356014460	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1282356014461	putative active site pocket [active]
1282356014462	4-fold oligomerization interface [polypeptide binding]; other site
1282356014463	metal binding residues [ion binding]; metal-binding site
1282356014464	3-fold/trimer interface [polypeptide binding]; other site
1282356014465	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
1282356014466	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1282356014467	putative active site [active]
1282356014468	oxyanion strand; other site
1282356014469	catalytic triad [active]
1282356014470	Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932
1282356014471	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1282356014472	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1282356014473	catalytic residues [active]
1282356014474	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1282356014475	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1282356014476	substrate binding site [chemical binding]; other site
1282356014477	glutamase interaction surface [polypeptide binding]; other site
1282356014478	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1282356014479	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1282356014480	substrate binding pocket [chemical binding]; other site
1282356014481	membrane-bound complex binding site; other site
1282356014482	hinge residues; other site
1282356014483	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
1282356014484	NodB motif; other site
1282356014485	putative active site [active]
1282356014486	putative catalytic site [active]
1282356014487	Zn binding site [ion binding]; other site
1282356014488	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1282356014489	C-terminal peptidase (prc); Region: prc; TIGR00225
1282356014490	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1282356014491	protein binding site [polypeptide binding]; other site
1282356014492	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1282356014493	Catalytic dyad [active]
1282356014494	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
1282356014495	Peptidase family M23; Region: Peptidase_M23; pfam01551
1282356014496	phosphoglyceromutase; Provisional; Region: PRK05434
1282356014497	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307
1282356014498	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1282356014499	active site residue [active]
1282356014500	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
1282356014501	GSH binding site [chemical binding]; other site
1282356014502	catalytic residues [active]
1282356014503	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
1282356014504	SecA binding site; other site
1282356014505	Preprotein binding site; other site
1282356014506	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1282356014507	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
1282356014508	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356014509	active site
1282356014510	phosphorylation site [posttranslational modification]
1282356014511	intermolecular recognition site; other site
1282356014512	dimerization interface [polypeptide binding]; other site
1282356014513	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356014514	Walker A motif; other site
1282356014515	ATP binding site [chemical binding]; other site
1282356014516	Walker B motif; other site
1282356014517	arginine finger; other site
1282356014518	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1282356014519	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1282356014520	PAS domain; Region: PAS; smart00091
1282356014521	putative active site [active]
1282356014522	heme pocket [chemical binding]; other site
1282356014523	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356014524	dimer interface [polypeptide binding]; other site
1282356014525	phosphorylation site [posttranslational modification]
1282356014526	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356014527	ATP binding site [chemical binding]; other site
1282356014528	Mg2+ binding site [ion binding]; other site
1282356014529	G-X-G motif; other site
1282356014530	chorismate mutase; Provisional; Region: PRK09269
1282356014531	Chorismate mutase type II; Region: CM_2; cl00693
1282356014532	glutamine synthetase; Provisional; Region: glnA; PRK09469
1282356014533	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1282356014534	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1282356014535	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
1282356014536	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
1282356014537	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
1282356014538	Ligand Binding Site [chemical binding]; other site
1282356014539	thiazole biosynthesis domain; Region: ThiI_C_thiazole; TIGR04271
1282356014540	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1282356014541	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1282356014542	G1 box; other site
1282356014543	putative GEF interaction site [polypeptide binding]; other site
1282356014544	GTP/Mg2+ binding site [chemical binding]; other site
1282356014545	Switch I region; other site
1282356014546	G2 box; other site
1282356014547	G3 box; other site
1282356014548	Switch II region; other site
1282356014549	G4 box; other site
1282356014550	G5 box; other site
1282356014551	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1282356014552	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1282356014553	Flagellin N-methylase; Region: FliB; pfam03692
1282356014554	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
1282356014555	homodimer interface [polypeptide binding]; other site
1282356014556	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
1282356014557	active site pocket [active]
1282356014558	fructose-1,6-bisphosphatase family protein; Region: PLN02628
1282356014559	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
1282356014560	AMP binding site [chemical binding]; other site
1282356014561	metal binding site [ion binding]; metal-binding site
1282356014562	active site
1282356014563	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
1282356014564	Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040
1282356014565	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
1282356014566	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
1282356014567	Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313
1282356014568	active site
1282356014569	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
1282356014570	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1282356014571	DNA-binding site [nucleotide binding]; DNA binding site
1282356014572	UTRA domain; Region: UTRA; pfam07702
1282356014573	HutD; Region: HutD; pfam05962
1282356014574	urocanate hydratase; Provisional; Region: PRK05414
1282356014575	Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457
1282356014576	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
1282356014577	Na binding site [ion binding]; other site
1282356014578	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
1282356014579	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1282356014580	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356014581	dimer interface [polypeptide binding]; other site
1282356014582	conserved gate region; other site
1282356014583	putative PBP binding loops; other site
1282356014584	ABC-ATPase subunit interface; other site
1282356014585	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1282356014586	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
1282356014587	Walker A/P-loop; other site
1282356014588	ATP binding site [chemical binding]; other site
1282356014589	Q-loop/lid; other site
1282356014590	ABC transporter signature motif; other site
1282356014591	Walker B; other site
1282356014592	D-loop; other site
1282356014593	H-loop/switch region; other site
1282356014594	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
1282356014595	active sites [active]
1282356014596	tetramer interface [polypeptide binding]; other site
1282356014597	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
1282356014598	active sites [active]
1282356014599	tetramer interface [polypeptide binding]; other site
1282356014600	imidazolonepropionase; Validated; Region: PRK09356
1282356014601	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
1282356014602	active site
1282356014603	N-formylglutamate amidohydrolase; Region: FGase; cl01522
1282356014604	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
1282356014605	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
1282356014606	putative active site [active]
1282356014607	dimerization interface [polypeptide binding]; other site
1282356014608	putative tRNAtyr binding site [nucleotide binding]; other site
1282356014609	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
1282356014610	Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433
1282356014611	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1282356014612	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
1282356014613	Ligand binding site; other site
1282356014614	DXD motif; other site
1282356014615	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1282356014616	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1282356014617	substrate binding pocket [chemical binding]; other site
1282356014618	membrane-bound complex binding site; other site
1282356014619	hinge residues; other site
1282356014620	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1282356014621	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1282356014622	substrate binding pocket [chemical binding]; other site
1282356014623	membrane-bound complex binding site; other site
1282356014624	hinge residues; other site
1282356014625	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1282356014626	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356014627	dimer interface [polypeptide binding]; other site
1282356014628	conserved gate region; other site
1282356014629	putative PBP binding loops; other site
1282356014630	ABC-ATPase subunit interface; other site
1282356014631	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1282356014632	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1282356014633	Walker A/P-loop; other site
1282356014634	ATP binding site [chemical binding]; other site
1282356014635	Q-loop/lid; other site
1282356014636	ABC transporter signature motif; other site
1282356014637	Walker B; other site
1282356014638	D-loop; other site
1282356014639	H-loop/switch region; other site
1282356014640	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1282356014641	dimerization interface [polypeptide binding]; other site
1282356014642	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1282356014643	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356014644	dimer interface [polypeptide binding]; other site
1282356014645	putative CheW interface [polypeptide binding]; other site
1282356014646	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1282356014647	dimerization interface [polypeptide binding]; other site
1282356014648	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1282356014649	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356014650	dimer interface [polypeptide binding]; other site
1282356014651	putative CheW interface [polypeptide binding]; other site
1282356014652	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
1282356014653	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
1282356014654	sec-independent translocase; Provisional; Region: tatB; PRK00404
1282356014655	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
1282356014656	twin arginine translocase protein A; Provisional; Region: tatA; PRK00442
1282356014657	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
1282356014658	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
1282356014659	metal binding site [ion binding]; metal-binding site
1282356014660	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
1282356014661	ABC1 family; Region: ABC1; cl17513
1282356014662	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
1282356014663	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
1282356014664	SCP-2 sterol transfer family; Region: SCP2; pfam02036
1282356014665	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1282356014666	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356014667	S-adenosylmethionine binding site [chemical binding]; other site
1282356014668	Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; pfam09650
1282356014669	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597
1282356014670	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597
1282356014671	Fimbrial protein; Region: Fimbrial; pfam00419
1282356014672	Fimbrial protein; Region: Fimbrial; pfam00419
1282356014673	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
1282356014674	PapC N-terminal domain; Region: PapC_N; pfam13954
1282356014675	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
1282356014676	PapC C-terminal domain; Region: PapC_C; pfam13953
1282356014677	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
1282356014678	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1282356014679	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
1282356014680	putative chaperone protein EcpD; Provisional; Region: PRK09926
1282356014681	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1282356014682	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
1282356014683	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1282356014684	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1282356014685	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356014686	active site
1282356014687	phosphorylation site [posttranslational modification]
1282356014688	intermolecular recognition site; other site
1282356014689	dimerization interface [polypeptide binding]; other site
1282356014690	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1282356014691	DNA binding residues [nucleotide binding]
1282356014692	dimerization interface [polypeptide binding]; other site
1282356014693	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1282356014694	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1282356014695	Bacterial transcriptional repressor; Region: TetR; pfam13972
1282356014696	poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240
1282356014697	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1282356014698	poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839
1282356014699	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
1282356014700	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
1282356014701	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
1282356014702	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1282356014703	Walker A motif; other site
1282356014704	ATP binding site [chemical binding]; other site
1282356014705	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
1282356014706	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
1282356014707	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
1282356014708	active site
1282356014709	HslU subunit interaction site [polypeptide binding]; other site
1282356014710	Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087
1282356014711	Sporulation related domain; Region: SPOR; pfam05036
1282356014712	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
1282356014713	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1282356014714	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1282356014715	active site
1282356014716	HIGH motif; other site
1282356014717	KMSK motif region; other site
1282356014718	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1282356014719	tRNA binding surface [nucleotide binding]; other site
1282356014720	anticodon binding site; other site
1282356014721	primosome assembly protein PriA; Validated; Region: PRK05580
1282356014722	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1282356014723	ATP binding site [chemical binding]; other site
1282356014724	putative Mg++ binding site [ion binding]; other site
1282356014725	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1282356014726	ATP-binding site [chemical binding]; other site
1282356014727	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
1282356014728	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
1282356014729	Catalytic site; other site
1282356014730	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
1282356014731	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1282356014732	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1282356014733	putative NAD(P) binding site [chemical binding]; other site
1282356014734	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
1282356014735	Transglycosylase; Region: Transgly; pfam00912
1282356014736	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1282356014737	Cell division protein FtsA; Region: FtsA; cl17206
1282356014738	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
1282356014739	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
1282356014740	Pilus assembly protein, PilO; Region: PilO; cl01234
1282356014741	Pilus assembly protein, PilP; Region: PilP; pfam04351
1282356014742	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
1282356014743	Secretin and TonB N terminus short domain; Region: STN; smart00965
1282356014744	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1282356014745	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1282356014746	shikimate kinase; Reviewed; Region: aroK; PRK00131
1282356014747	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1282356014748	ADP binding site [chemical binding]; other site
1282356014749	magnesium binding site [ion binding]; other site
1282356014750	putative shikimate binding site; other site
1282356014751	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1282356014752	active site
1282356014753	dimer interface [polypeptide binding]; other site
1282356014754	metal binding site [ion binding]; metal-binding site
1282356014755	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
1282356014756	Part of AAA domain; Region: AAA_19; pfam13245
1282356014757	Sporulation related domain; Region: SPOR; pfam05036
1282356014758	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
1282356014759	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1282356014760	active site
1282356014761	dimer interface [polypeptide binding]; other site
1282356014762	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1282356014763	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1282356014764	active site
1282356014765	FMN binding site [chemical binding]; other site
1282356014766	substrate binding site [chemical binding]; other site
1282356014767	3Fe-4S cluster binding site [ion binding]; other site
1282356014768	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
1282356014769	domain interface; other site
1282356014770	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
1282356014771	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1282356014772	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
1282356014773	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1282356014774	substrate binding site [chemical binding]; other site
1282356014775	active site
1282356014776	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1282356014777	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356014778	putative substrate translocation pore; other site
1282356014779	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
1282356014780	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356014781	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
1282356014782	dimerization interface [polypeptide binding]; other site
1282356014783	substrate binding pocket [chemical binding]; other site
1282356014784	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116
1282356014785	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1282356014786	dimer interface [polypeptide binding]; other site
1282356014787	active site
1282356014788	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1282356014789	3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831
1282356014790	NAD(P) binding site [chemical binding]; other site
1282356014791	homotetramer interface [polypeptide binding]; other site
1282356014792	homodimer interface [polypeptide binding]; other site
1282356014793	active site
1282356014794	Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289
1282356014795	putative active site 1 [active]
1282356014796	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185
1282356014797	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1282356014798	dimer interface [polypeptide binding]; other site
1282356014799	active site
1282356014800	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1282356014801	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356014802	S-adenosylmethionine binding site [chemical binding]; other site
1282356014803	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
1282356014804	Predicted exporter [General function prediction only]; Region: COG4258
1282356014805	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
1282356014806	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1282356014807	active site
1282356014808	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
1282356014809	active sites [active]
1282356014810	tetramer interface [polypeptide binding]; other site
1282356014811	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1282356014812	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1282356014813	putative acyl-acceptor binding pocket; other site
1282356014814	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1282356014815	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
1282356014816	Ligand binding site; other site
1282356014817	Putative Catalytic site; other site
1282356014818	DXD motif; other site
1282356014819	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1282356014820	AMP-binding enzyme; Region: AMP-binding; pfam00501
1282356014821	active site
1282356014822	AMP binding site [chemical binding]; other site
1282356014823	acyl-activating enzyme (AAE) consensus motif; other site
1282356014824	CoA binding site [chemical binding]; other site
1282356014825	FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493
1282356014826	active site 2 [active]
1282356014827	dimer interface [polypeptide binding]; other site
1282356014828	active site 1 [active]
1282356014829	Predicted membrane protein [Function unknown]; Region: COG4648
1282356014830	acyl carrier protein; Provisional; Region: PRK05350
1282356014831	Phosphopantetheine attachment site; Region: PP-binding; cl09936
1282356014832	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1282356014833	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1282356014834	putative acyl-acceptor binding pocket; other site
1282356014835	Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723
1282356014836	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1282356014837	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1282356014838	P-loop; other site
1282356014839	Magnesium ion binding site [ion binding]; other site
1282356014840	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1282356014841	Magnesium ion binding site [ion binding]; other site
1282356014842	thioredoxin 2; Provisional; Region: PRK10996
1282356014843	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1282356014844	catalytic residues [active]
1282356014845	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
1282356014846	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1282356014847	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1282356014848	Uncharacterized conserved protein [Function unknown]; Region: COG0397
1282356014849	hypothetical protein; Validated; Region: PRK00029
1282356014850	hypothetical protein; Provisional; Region: PRK11281
1282356014851	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
1282356014852	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1282356014853	NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263
1282356014854	TrkA-C domain; Region: TrkA_C; pfam02080
1282356014855	Transporter associated domain; Region: CorC_HlyC; smart01091
1282356014856	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1282356014857	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1282356014858	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1282356014859	dimerization interface [polypeptide binding]; other site
1282356014860	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356014861	dimer interface [polypeptide binding]; other site
1282356014862	putative CheW interface [polypeptide binding]; other site
1282356014863	Cell division protein ZapA; Region: ZapA; pfam05164
1282356014864	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
1282356014865	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
1282356014866	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1282356014867	active site
1282356014868	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
1282356014869	trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809
1282356014870	Predicted transcriptional regulator [Transcription]; Region: COG3905
1282356014871	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
1282356014872	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
1282356014873	Glutamate binding site [chemical binding]; other site
1282356014874	NAD binding site [chemical binding]; other site
1282356014875	catalytic residues [active]
1282356014876	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
1282356014877	Na binding site [ion binding]; other site
1282356014878	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
1282356014879	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
1282356014880	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
1282356014881	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
1282356014882	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
1282356014883	methionine sulfoxide reductase A; Provisional; Region: PRK00058
1282356014884	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1282356014885	putative active site [active]
1282356014886	heme pocket [chemical binding]; other site
1282356014887	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1282356014888	GAF domain; Region: GAF; pfam01590
1282356014889	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1282356014890	PAS domain; Region: PAS_9; pfam13426
1282356014891	putative active site [active]
1282356014892	heme pocket [chemical binding]; other site
1282356014893	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1282356014894	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1282356014895	metal binding site [ion binding]; metal-binding site
1282356014896	active site
1282356014897	I-site; other site
1282356014898	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1282356014899	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1282356014900	E3 interaction surface; other site
1282356014901	lipoyl attachment site [posttranslational modification]; other site
1282356014902	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508
1282356014903	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1282356014904	E3 interaction surface; other site
1282356014905	lipoyl attachment site [posttranslational modification]; other site
1282356014906	e3 binding domain; Region: E3_binding; pfam02817
1282356014907	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1282356014908	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
1282356014909	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
1282356014910	dimer interface [polypeptide binding]; other site
1282356014911	TPP-binding site [chemical binding]; other site
1282356014912	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
1282356014913	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1282356014914	metal binding triad; other site
1282356014915	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1282356014916	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1282356014917	metal binding triad; other site
1282356014918	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1282356014919	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1282356014920	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1282356014921	putative active site [active]
1282356014922	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1282356014923	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1282356014924	putative active site [active]
1282356014925	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1282356014926	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1282356014927	lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123
1282356014928	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
1282356014929	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; pfam06293
1282356014930	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1282356014931	active site
1282356014932	ATP binding site [chemical binding]; other site
1282356014933	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
1282356014934	Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305
1282356014935	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1282356014936	putative ligand binding site [chemical binding]; other site
1282356014937	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1282356014938	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1282356014939	Walker A/P-loop; other site
1282356014940	ATP binding site [chemical binding]; other site
1282356014941	Q-loop/lid; other site
1282356014942	ABC transporter signature motif; other site
1282356014943	Walker B; other site
1282356014944	D-loop; other site
1282356014945	H-loop/switch region; other site
1282356014946	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1282356014947	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
1282356014948	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1282356014949	TM-ABC transporter signature motif; other site
1282356014950	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1282356014951	TM-ABC transporter signature motif; other site
1282356014952	Protein of unknown function (DUF1375); Region: DUF1375; pfam07119
1282356014953	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
1282356014954	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
1282356014955	Mig-14; Region: Mig-14; pfam07395
1282356014956	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
1282356014957	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
1282356014958	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1282356014959	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1282356014960	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1282356014961	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1282356014962	active site
1282356014963	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
1282356014964	Phosphotransferase enzyme family; Region: APH; pfam01636
1282356014965	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1282356014966	active site
1282356014967	substrate binding site [chemical binding]; other site
1282356014968	ATP binding site [chemical binding]; other site
1282356014969	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
1282356014970	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1282356014971	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1282356014972	Walker A/P-loop; other site
1282356014973	ATP binding site [chemical binding]; other site
1282356014974	Q-loop/lid; other site
1282356014975	ABC transporter signature motif; other site
1282356014976	Walker B; other site
1282356014977	D-loop; other site
1282356014978	H-loop/switch region; other site
1282356014979	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
1282356014980	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
1282356014981	putative ribose interaction site [chemical binding]; other site
1282356014982	putative ADP binding site [chemical binding]; other site
1282356014983	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
1282356014984	active site
1282356014985	nucleotide binding site [chemical binding]; other site
1282356014986	HIGH motif; other site
1282356014987	KMSKS motif; other site
1282356014988	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1282356014989	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1282356014990	NAD(P) binding site [chemical binding]; other site
1282356014991	active site
1282356014992	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1282356014993	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1282356014994	active site
1282356014995	catalytic tetrad [active]
1282356014996	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
1282356014997	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1282356014998	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1282356014999	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
1282356015000	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
1282356015001	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1282356015002	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
1282356015003	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
1282356015004	ThiC-associated domain; Region: ThiC-associated; pfam13667
1282356015005	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
1282356015006	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1282356015007	Na binding site [ion binding]; other site
1282356015008	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
1282356015009	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
1282356015010	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1282356015011	dimer interface [polypeptide binding]; other site
1282356015012	ADP-ribose binding site [chemical binding]; other site
1282356015013	active site
1282356015014	nudix motif; other site
1282356015015	metal binding site [ion binding]; metal-binding site
1282356015016	Protein of unknown function (DUF1249); Region: DUF1249; pfam06853
1282356015017	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
1282356015018	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1282356015019	active site
1282356015020	metal binding site [ion binding]; metal-binding site
1282356015021	hexamer interface [polypeptide binding]; other site
1282356015022	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
1282356015023	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1282356015024	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
1282356015025	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356015026	ATP binding site [chemical binding]; other site
1282356015027	Mg2+ binding site [ion binding]; other site
1282356015028	G-X-G motif; other site
1282356015029	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1282356015030	anchoring element; other site
1282356015031	dimer interface [polypeptide binding]; other site
1282356015032	ATP binding site [chemical binding]; other site
1282356015033	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
1282356015034	active site
1282356015035	metal binding site [ion binding]; metal-binding site
1282356015036	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1282356015037	SdiA-regulated; Region: SdiA-regulated; cd09971
1282356015038	putative active site [active]
1282356015039	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
1282356015040	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1282356015041	CAP-like domain; other site
1282356015042	active site
1282356015043	primary dimer interface [polypeptide binding]; other site
1282356015044	Protein of unknown function (DUF330); Region: DUF330; pfam03886
1282356015045	Uncharacterized membrane protein affecting hemolysin expression [General function prediction only]; Region: AhpA; COG3726
1282356015046	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
1282356015047	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
1282356015048	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
1282356015049	phosphoserine phosphatase SerB; Region: serB; TIGR00338
1282356015050	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1282356015051	motif II; other site
1282356015052	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
1282356015053	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1282356015054	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1282356015055	active site residue [active]
1282356015056	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1282356015057	active site residue [active]
1282356015058	HDOD domain; Region: HDOD; pfam08668
1282356015059	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
1282356015060	flagellar motor protein MotA; Validated; Region: PRK09110
1282356015061	flagellar motor protein MotB; Validated; Region: motB; PRK09041
1282356015062	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
1282356015063	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1282356015064	ligand binding site [chemical binding]; other site
1282356015065	GTPase RsgA; Reviewed; Region: PRK12288
1282356015066	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1282356015067	RNA binding site [nucleotide binding]; other site
1282356015068	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1282356015069	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1282356015070	GTP/Mg2+ binding site [chemical binding]; other site
1282356015071	G4 box; other site
1282356015072	G5 box; other site
1282356015073	G1 box; other site
1282356015074	Switch I region; other site
1282356015075	G2 box; other site
1282356015076	G3 box; other site
1282356015077	Switch II region; other site
1282356015078	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
1282356015079	catalytic site [active]
1282356015080	putative active site [active]
1282356015081	putative substrate binding site [chemical binding]; other site
1282356015082	dimer interface [polypeptide binding]; other site
1282356015083	Predicted membrane protein [Function unknown]; Region: COG2860
1282356015084	UPF0126 domain; Region: UPF0126; pfam03458
1282356015085	UPF0126 domain; Region: UPF0126; pfam03458
1282356015086	epoxyqueuosine reductase; Region: TIGR00276
1282356015087	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
1282356015088	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1282356015089	putative substrate binding site [chemical binding]; other site
1282356015090	putative ATP binding site [chemical binding]; other site
1282356015091	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
1282356015092	AMIN domain; Region: AMIN; pfam11741
1282356015093	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1282356015094	active site
1282356015095	metal binding site [ion binding]; metal-binding site
1282356015096	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1282356015097	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
1282356015098	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356015099	ATP binding site [chemical binding]; other site
1282356015100	Mg2+ binding site [ion binding]; other site
1282356015101	G-X-G motif; other site
1282356015102	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
1282356015103	ATP binding site [chemical binding]; other site
1282356015104	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
1282356015105	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1282356015106	tRNA dimethylallyltransferase; Region: miaA; TIGR00174
1282356015107	bacterial Hfq-like; Region: Hfq; cd01716
1282356015108	hexamer interface [polypeptide binding]; other site
1282356015109	Sm1 motif; other site
1282356015110	RNA binding site [nucleotide binding]; other site
1282356015111	Sm2 motif; other site
1282356015112	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
1282356015113	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1282356015114	HflX GTPase family; Region: HflX; cd01878
1282356015115	G1 box; other site
1282356015116	GTP/Mg2+ binding site [chemical binding]; other site
1282356015117	Switch I region; other site
1282356015118	G2 box; other site
1282356015119	G3 box; other site
1282356015120	Switch II region; other site
1282356015121	G4 box; other site
1282356015122	G5 box; other site
1282356015123	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
1282356015124	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
1282356015125	HflK protein; Region: hflK; TIGR01933
1282356015126	HflC protein; Region: hflC; TIGR01932
1282356015127	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
1282356015128	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421
1282356015129	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1282356015130	dimer interface [polypeptide binding]; other site
1282356015131	motif 1; other site
1282356015132	active site
1282356015133	motif 2; other site
1282356015134	motif 3; other site
1282356015135	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1282356015136	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1282356015137	GDP-binding site [chemical binding]; other site
1282356015138	ACT binding site; other site
1282356015139	IMP binding site; other site
1282356015140	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356015141	dimer interface [polypeptide binding]; other site
1282356015142	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
1282356015143	putative CheW interface [polypeptide binding]; other site
1282356015144	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1282356015145	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356015146	dimer interface [polypeptide binding]; other site
1282356015147	conserved gate region; other site
1282356015148	putative PBP binding loops; other site
1282356015149	ABC-ATPase subunit interface; other site
1282356015150	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1282356015151	dimer interface [polypeptide binding]; other site
1282356015152	conserved gate region; other site
1282356015153	putative PBP binding loops; other site
1282356015154	ABC-ATPase subunit interface; other site
1282356015155	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1282356015156	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1282356015157	ribonuclease R; Region: RNase_R; TIGR02063
1282356015158	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1282356015159	RNB domain; Region: RNB; pfam00773
1282356015160	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
1282356015161	RNA binding site [nucleotide binding]; other site
1282356015162	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
1282356015163	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1282356015164	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1282356015165	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1282356015166	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1282356015167	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1282356015168	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1282356015169	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1282356015170	replicative DNA helicase; Provisional; Region: PRK05748
1282356015171	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1282356015172	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1282356015173	Walker A motif; other site
1282356015174	ATP binding site [chemical binding]; other site
1282356015175	Walker B motif; other site
1282356015176	DNA binding loops [nucleotide binding]
1282356015177	SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317
1282356015178	hypothetical protein; Provisional; Region: PRK01254
1282356015179	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
1282356015180	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
1282356015181	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
1282356015182	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1282356015183	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1282356015184	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
1282356015185	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
1282356015186	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
1282356015187	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
1282356015188	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
1282356015189	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1282356015190	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
1282356015191	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1282356015192	azurin; Region: azurin; TIGR02695
1282356015193	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
1282356015194	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1282356015195	homodimer interface [polypeptide binding]; other site
1282356015196	NAD binding pocket [chemical binding]; other site
1282356015197	ATP binding pocket [chemical binding]; other site
1282356015198	Mg binding site [ion binding]; other site
1282356015199	active-site loop [active]
1282356015200	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
1282356015201	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
1282356015202	active site
1282356015203	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1282356015204	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356015205	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1282356015206	dimerization interface [polypeptide binding]; other site
1282356015207	aldehyde dehydrogenase family 7 member; Region: PLN02315
1282356015208	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
1282356015209	tetrameric interface [polypeptide binding]; other site
1282356015210	NAD binding site [chemical binding]; other site
1282356015211	catalytic residues [active]
1282356015212	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1282356015213	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1282356015214	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1282356015215	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1282356015216	dimerization interface [polypeptide binding]; other site
1282356015217	ligand binding site [chemical binding]; other site
1282356015218	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1282356015219	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1282356015220	TM-ABC transporter signature motif; other site
1282356015221	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
1282356015222	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
1282356015223	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1282356015224	TM-ABC transporter signature motif; other site
1282356015225	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
1282356015226	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1282356015227	Walker A/P-loop; other site
1282356015228	ATP binding site [chemical binding]; other site
1282356015229	Q-loop/lid; other site
1282356015230	ABC transporter signature motif; other site
1282356015231	Walker B; other site
1282356015232	D-loop; other site
1282356015233	H-loop/switch region; other site
1282356015234	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1282356015235	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1282356015236	Walker A/P-loop; other site
1282356015237	ATP binding site [chemical binding]; other site
1282356015238	Q-loop/lid; other site
1282356015239	ABC transporter signature motif; other site
1282356015240	Walker B; other site
1282356015241	D-loop; other site
1282356015242	H-loop/switch region; other site
1282356015243	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1282356015244	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
1282356015245	putative NAD(P) binding site [chemical binding]; other site
1282356015246	homotetramer interface [polypeptide binding]; other site
1282356015247	homodimer interface [polypeptide binding]; other site
1282356015248	active site
1282356015249	dimerization interface [polypeptide binding]; other site
1282356015250	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
1282356015251	putative active cleft [active]
1282356015252	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
1282356015253	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1282356015254	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
1282356015255	UreF; Region: UreF; pfam01730
1282356015256	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
1282356015257	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
1282356015258	dimer interface [polypeptide binding]; other site
1282356015259	catalytic residues [active]
1282356015260	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
1282356015261	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1282356015262	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
1282356015263	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1282356015264	Ferritin-like domain; Region: Ferritin; pfam00210
1282356015265	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
1282356015266	dinuclear metal binding motif [ion binding]; other site
1282356015267	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1282356015268	EamA-like transporter family; Region: EamA; pfam00892
1282356015269	psiF repeat; Region: PsiF_repeat; pfam07769
1282356015270	psiF repeat; Region: PsiF_repeat; pfam07769
1282356015271	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
1282356015272	putative chaperone; Provisional; Region: PRK11678
1282356015273	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
1282356015274	nucleotide binding site [chemical binding]; other site
1282356015275	putative NEF/HSP70 interaction site [polypeptide binding]; other site
1282356015276	SBD interface [polypeptide binding]; other site
1282356015277	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
1282356015278	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1282356015279	HSP70 interaction site [polypeptide binding]; other site
1282356015280	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1282356015281	substrate binding site [polypeptide binding]; other site
1282356015282	dimer interface [polypeptide binding]; other site
1282356015283	urease subunit alpha; Reviewed; Region: ureC; PRK13207
1282356015284	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
1282356015285	subunit interactions [polypeptide binding]; other site
1282356015286	active site
1282356015287	flap region; other site
1282356015288	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
1282356015289	gamma-beta subunit interface [polypeptide binding]; other site
1282356015290	alpha-beta subunit interface [polypeptide binding]; other site
1282356015291	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1282356015292	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1282356015293	Coenzyme A binding pocket [chemical binding]; other site
1282356015294	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1282356015295	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1282356015296	Coenzyme A binding pocket [chemical binding]; other site
1282356015297	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
1282356015298	alpha-gamma subunit interface [polypeptide binding]; other site
1282356015299	beta-gamma subunit interface [polypeptide binding]; other site
1282356015300	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
1282356015301	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
1282356015302	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1282356015303	Walker A/P-loop; other site
1282356015304	ATP binding site [chemical binding]; other site
1282356015305	Q-loop/lid; other site
1282356015306	ABC transporter signature motif; other site
1282356015307	Walker B; other site
1282356015308	D-loop; other site
1282356015309	H-loop/switch region; other site
1282356015310	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
1282356015311	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1282356015312	Walker A/P-loop; other site
1282356015313	ATP binding site [chemical binding]; other site
1282356015314	Q-loop/lid; other site
1282356015315	ABC transporter signature motif; other site
1282356015316	Walker B; other site
1282356015317	D-loop; other site
1282356015318	H-loop/switch region; other site
1282356015319	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1282356015320	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1282356015321	TM-ABC transporter signature motif; other site
1282356015322	HEAT repeats; Region: HEAT_2; pfam13646
1282356015323	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1282356015324	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1282356015325	TM-ABC transporter signature motif; other site
1282356015326	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1282356015327	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
1282356015328	putative ligand binding site [chemical binding]; other site
1282356015329	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1282356015330	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1282356015331	ABC-ATPase subunit  interface; other site
1282356015332	dimer interface [polypeptide binding]; other site
1282356015333	putative PBP binding regions; other site
1282356015334	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
1282356015335	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
1282356015336	putative ligand binding residues [chemical binding]; other site
1282356015337	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1282356015338	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1282356015339	Walker A/P-loop; other site
1282356015340	ATP binding site [chemical binding]; other site
1282356015341	Q-loop/lid; other site
1282356015342	ABC transporter signature motif; other site
1282356015343	Walker B; other site
1282356015344	D-loop; other site
1282356015345	H-loop/switch region; other site
1282356015346	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1282356015347	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1282356015348	N-terminal plug; other site
1282356015349	ligand-binding site [chemical binding]; other site
1282356015350	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1282356015351	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
1282356015352	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1282356015353	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1282356015354	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1282356015355	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
1282356015356	Protein of unknown function (DUF461); Region: DUF461; pfam04314
1282356015357	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
1282356015358	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
1282356015359	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
1282356015360	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
1282356015361	active site
1282356015362	putative homodimer interface [polypeptide binding]; other site
1282356015363	SAM binding site [chemical binding]; other site
1282356015364	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
1282356015365	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356015366	S-adenosylmethionine binding site [chemical binding]; other site
1282356015367	precorrin-3B synthase; Region: CobG; TIGR02435
1282356015368	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1282356015369	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
1282356015370	Precorrin-8X methylmutase; Region: CbiC; pfam02570
1282356015371	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
1282356015372	active site
1282356015373	SAM binding site [chemical binding]; other site
1282356015374	homodimer interface [polypeptide binding]; other site
1282356015375	Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073
1282356015376	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
1282356015377	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
1282356015378	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
1282356015379	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
1282356015380	active site
1282356015381	SAM binding site [chemical binding]; other site
1282356015382	homodimer interface [polypeptide binding]; other site
1282356015383	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
1282356015384	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
1282356015385	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1282356015386	dimer interface [polypeptide binding]; other site
1282356015387	phosphorylation site [posttranslational modification]
1282356015388	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1282356015389	ATP binding site [chemical binding]; other site
1282356015390	Mg2+ binding site [ion binding]; other site
1282356015391	G-X-G motif; other site
1282356015392	Response regulator receiver domain; Region: Response_reg; pfam00072
1282356015393	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356015394	active site
1282356015395	phosphorylation site [posttranslational modification]
1282356015396	intermolecular recognition site; other site
1282356015397	dimerization interface [polypeptide binding]; other site
1282356015398	Response regulator receiver domain; Region: Response_reg; pfam00072
1282356015399	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356015400	active site
1282356015401	phosphorylation site [posttranslational modification]
1282356015402	intermolecular recognition site; other site
1282356015403	dimerization interface [polypeptide binding]; other site
1282356015404	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1282356015405	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1282356015406	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1282356015407	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1282356015408	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1282356015409	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1282356015410	purine monophosphate binding site [chemical binding]; other site
1282356015411	dimer interface [polypeptide binding]; other site
1282356015412	putative catalytic residues [active]
1282356015413	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1282356015414	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1282356015415	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
1282356015416	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
1282356015417	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
1282356015418	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1282356015419	FMN binding site [chemical binding]; other site
1282356015420	active site
1282356015421	catalytic residues [active]
1282356015422	substrate binding site [chemical binding]; other site
1282356015423	MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098
1282356015424	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
1282356015425	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
1282356015426	Methyltransferase domain; Region: Methyltransf_18; pfam12847
1282356015427	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1282356015428	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1282356015429	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1282356015430	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1282356015431	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1282356015432	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1282356015433	carboxyltransferase (CT) interaction site; other site
1282356015434	biotinylation site [posttranslational modification]; other site
1282356015435	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1282356015436	Dehydroquinase class II; Region: DHquinase_II; pfam01220
1282356015437	trimer interface [polypeptide binding]; other site
1282356015438	active site
1282356015439	dimer interface [polypeptide binding]; other site
1282356015440	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1282356015441	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1282356015442	dimer interface [polypeptide binding]; other site
1282356015443	putative CheW interface [polypeptide binding]; other site
1282356015444	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
1282356015445	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1282356015446	active site
1282356015447	phosphorylation site [posttranslational modification]
1282356015448	intermolecular recognition site; other site
1282356015449	dimerization interface [polypeptide binding]; other site
1282356015450	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1282356015451	metal binding site [ion binding]; metal-binding site
1282356015452	active site
1282356015453	I-site; other site
1282356015454	Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; pfam10095
1282356015455	NUDIX hydrolase YfcD; Provisional; Region: PRK15393
1282356015456	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1282356015457	nudix motif; other site
1282356015458	translation initiation factor Sui1; Validated; Region: PRK06824
1282356015459	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
1282356015460	putative rRNA binding site [nucleotide binding]; other site
1282356015461	arginine decarboxylase; Provisional; Region: PRK05354
1282356015462	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
1282356015463	dimer interface [polypeptide binding]; other site
1282356015464	active site
1282356015465	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1282356015466	catalytic residues [active]
1282356015467	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
1282356015468	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1282356015469	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1282356015470	substrate binding pocket [chemical binding]; other site
1282356015471	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
1282356015472	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
1282356015473	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
1282356015474	MG2 domain; Region: A2M_N; pfam01835
1282356015475	Alpha-2-macroglobulin family; Region: A2M; pfam00207
1282356015476	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
1282356015477	surface patch; other site
1282356015478	thioester region; other site
1282356015479	specificity defining residues; other site
1282356015480	penicillin-binding protein 1C; Provisional; Region: PRK11240
1282356015481	Transglycosylase; Region: Transgly; pfam00912
1282356015482	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1282356015483	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
1282356015484	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
1282356015485	homodimer interface [polypeptide binding]; other site
1282356015486	chemical substrate binding site [chemical binding]; other site
1282356015487	oligomer interface [polypeptide binding]; other site
1282356015488	metal binding site [ion binding]; metal-binding site
1282356015489	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1282356015490	S-adenosylmethionine binding site [chemical binding]; other site
1282356015491	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
1282356015492	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
1282356015493	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1282356015494	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1282356015495	active site 2 [active]
1282356015496	active site 1 [active]
1282356015497	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
1282356015498	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1282356015499	NAD(P) binding site [chemical binding]; other site
1282356015500	active site
1282356015501	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
1282356015502	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1282356015503	dimer interface [polypeptide binding]; other site
1282356015504	active site
1282356015505	Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718
1282356015506	RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145
1282356015507	ATP binding site [chemical binding]; other site
1282356015508	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
1282356015509	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
1282356015510	DNA binding residues [nucleotide binding]
1282356015511	dimer interface [polypeptide binding]; other site
1282356015512	copper binding site [ion binding]; other site
1282356015513	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1282356015514	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1282356015515	metal-binding site [ion binding]
1282356015516	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1282356015517	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356015518	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
1282356015519	putative substrate translocation pore; other site
1282356015520	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
1282356015521	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
1282356015522	putative NAD(P) binding site [chemical binding]; other site
1282356015523	dimer interface [polypeptide binding]; other site
1282356015524	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1282356015525	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356015526	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356015527	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1282356015528	putative effector binding pocket; other site
1282356015529	dimerization interface [polypeptide binding]; other site
1282356015530	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1282356015531	dimerization interface [polypeptide binding]; other site
1282356015532	putative DNA binding site [nucleotide binding]; other site
1282356015533	putative Zn2+ binding site [ion binding]; other site
1282356015534	benzoate transport; Region: 2A0115; TIGR00895
1282356015535	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356015536	putative substrate translocation pore; other site
1282356015537	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1282356015538	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
1282356015539	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
1282356015540	active site
1282356015541	purine riboside binding site [chemical binding]; other site
1282356015542	Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
1282356015543	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1282356015544	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
1282356015545	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
1282356015546	active site
1282356015547	putative substrate binding pocket [chemical binding]; other site
1282356015548	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1282356015549	short chain dehydrogenase; Provisional; Region: PRK08177
1282356015550	NAD(P) binding site [chemical binding]; other site
1282356015551	active site
1282356015552	Uncharacterized conserved protein [Function unknown]; Region: COG1739
1282356015553	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1282356015554	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1282356015555	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
1282356015556	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1282356015557	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
1282356015558	xanthine permease; Region: pbuX; TIGR03173
1282356015559	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1282356015560	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1282356015561	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1282356015562	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1282356015563	dimerization interface [polypeptide binding]; other site
1282356015564	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
1282356015565	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1282356015566	inhibitor-cofactor binding pocket; inhibition site
1282356015567	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1282356015568	catalytic residue [active]
1282356015569	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1282356015570	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
1282356015571	tetrameric interface [polypeptide binding]; other site
1282356015572	NAD binding site [chemical binding]; other site
1282356015573	catalytic residues [active]